indomethacin has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 4 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, PVR was induced in pups in utero by exposure of pregnant dams to indomethacin and hypoxia and cardiac lipids, echocardiographic function and cardiomyocyte mitochondrial function were subsequently examined." | 4.12 | Altered cardiolipin metabolism is associated with cardiac mitochondrial dysfunction in pulmonary vascular remodeled perinatal rat pups. ( Cole, LK; Dolinsky, VW; Hatch, GM; Sparagna, GC, 2022) |
| "Quercetin was the most efficient in protecting against mitochondrial dysfunction; this could be due to its ability to enter cells and accumulate in mitochondria." | 1.38 | Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. ( Carrasco-Pozo, C; Gotteland, M; Mizgier, ML; Speisky, H, 2012) |
| "Pre-treatment with curcumin was found to ameliorate these drug-induced changes." | 1.35 | Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. ( Balasubramanian, KA; Basivireddy, J; Jacob, M; Sivalingam, N, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cole, LK | 1 |
| Sparagna, GC | 1 |
| Dolinsky, VW | 1 |
| Hatch, GM | 1 |
| Carrasco-Pozo, C | 2 |
| Gotteland, M | 2 |
| Speisky, H | 2 |
| Mizgier, ML | 1 |
| Sivalingam, N | 1 |
| Basivireddy, J | 1 |
| Balasubramanian, KA | 1 |
| Jacob, M | 1 |
4 other studies available for indomethacin and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Altered cardiolipin metabolism is associated with cardiac mitochondrial dysfunction in pulmonary vascular remodeled perinatal rat pups.
Topics: Animals; Animals, Newborn; Cardiolipins; Disease Models, Animal; Female; Hypoxia; Indomethacin; Mito | 2022 |
Protection by apple peel polyphenols against indometacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 cells.
Topics: Adenosine Triphosphate; Antioxidants; Caco-2 Cells; Cell Line, Tumor; Cell Survival; Dose-Response R | 2010 |
Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells.
Topics: Adenosine Triphosphate; Caco-2 Cells; Catechin; Drug Interactions; Electron Transport Complex I; Gas | 2012 |
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Indomethacin; Inte | 2008 |