indomethacin has been researched along with Edema in 868 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a prospective, double-masked, controlled study to determine the effects of indomethacin in preventing the development of cystoid macular edema after retinal detachment surgery." | 9.05 | Incidence of cystoid macular edema after retinal detachment surgery and the use of topical indomethacin. ( Asakura, M; Maekubo, K; Manabe, R; Miyake, K; Miyake, Y, 1983) |
| "A prospective double-masked study of 500 patients was performed to assess the effect of topical indomethacin on the angiographic incidence of cystoid macular edema (CME) in patients undergoing intraocular lens implant surgery." | 9.05 | Prophylaxis of pseudophakic cystoid macular edema with topical indomethacin. ( Jampol, LM; Kraff, MC; Lieberman, HL; Peyman, GA; Sanders, DR, 1982) |
| "A prospective, controlled study utilizing topical 1% aqueous indomethacin was employed in an attempt to determine the incidence of aphakic cystoid macular edema (ACME) following cataract surgery." | 9.05 | Incidence of aphakic cystoid macular edema with the use of topical indomethacin. ( Landau, AN; Turtz, AI; Yannuzzi, LA, 1981) |
| "A controlled, double-masked study in which patients with cystoid macular edema of more than four months' duration were treated with indomethacin failed to demonstrate a significant visual improvement when compared to patients who were treated with placebo." | 9.04 | Ineffectiveness of indomethacin in the treatment of chronic cystoid macular edema. ( Cohen, N; Katiz, I; Klein, RM; Wallyn, RH; Yannuzzi, LA, 1977) |
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 7.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| " Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin." | 7.79 | New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2013) |
| "We investigated the effect of argirein on acute inflammation edema and examined that aquaporin 4 (AQP4), p66Shc and activating transcription factor (ATF-6) might be involved in carrageenan-induced rat paw inflammation and be reversed by argirein, rhein and indometacin, but not L-arginine." | 7.78 | Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| "Anti-inflammatory and antioxidative potential of hesperidin and naringin was carried out considering the rat air pouch model of inflammation." | 7.77 | Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. ( Jain, M; Parmar, HS, 2011) |
| "To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema." | 7.76 | Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats. ( Hajhashemi, V; Minaiyan, M; Movahedian, A; Sadeghi, H; Talebi, A, 2010) |
| " However, the role of LXA4 and aspirin (ASA)-triggered lipoxins (ATLs) in inflammatory edema formation remains unclear." | 7.73 | Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. ( Calixto, JB; Henriques, Md; Kassuya, CA; Menezes-de-Lima, O; Nascimento, AF, 2006) |
| "Combining allopurinol with either diclofenac or indomethacin produced synergistic inhibitory action on rat's paw edema." | 7.72 | Interaction of allopurinol and non-steroidal anti-inflammatory drugs on the carrageenan-induced rat paw edema. ( Al-Arfaj, AS; Al-Dalaan, AN; Alballa, SR; Mustafa, AA; Tuwaijri, AS, 2003) |
| "The tachykinin neurokinin B (NKB) has been implicated in the hypertension that characterises pre-eclampsia, a condition where tissue oedema is also observed." | 7.71 | Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms. ( Akhtar, R; Brain, SD; Gerard, NP; Grant, AD, 2002) |
| "The objectives of this study were to evaluate the anti-inflammatory effects and possible drug interactions of butorphanol by using carrageenan-induced paw inflammation in rats." | 7.71 | Butorphanol decreases edema following carrageenan-induced paw inflammation in rats. ( Moreau, JP; Vachon, P, 2002) |
| "This study evaluates the action of celecoxib and rofecoxib, two selective cyclooxygenase-2 (COX-2) inhibitors in two acute models of inflammation, carrageenan (Cg)-induced rat pleurisy, and paw oedema formation." | 7.71 | Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. ( Calixto, JB; Pinheiro, RM, 2002) |
| " The antiinflammatory activity of synthetic cannabinoid nabilone in the rat model of carrageenan-induced acute hindpaw inflammation was compared with that of the endocannabinoid palmitoylethanolamide and the nonsteroidal antiinflammatory drug indomethacin." | 7.71 | Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. ( Colleoni, M; Conti, S; Costa, B; Giagnoni, G; Parolaro, D, 2002) |
| " In the present study, therefore, we used the non-steroidal anti-inflammatory drugs indomethacin and sodium salicylate in carrageenan-induced rat paw inflammation, in order to compare their anti-inflammatory action (determined as inhibition of edema) with their effects on the concentration of NGF in inflamed tissue." | 7.70 | Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw. ( Amann, R; Schuligoi, R, 2000) |
| "To prove that prostaglandin I2 (PGI2) is a major prostaglandin involved in bradykinin-induced exudation, we examined carrageenin- or bradykinin-induced paw edema in prostacyclin receptor-deficient mice (IPKO)." | 7.70 | Intrinsic prostacyclin contributes to exudation induced by bradykinin or carrageenin: a study on the paw edema induced in IP-receptor-deficient mice. ( Ikeda, Y; Murata, T; Naraba, H; Narumiya, S; Oh-ishi, S; Ueno, A; Ushikubi, F, 2000) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 7.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| "Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice." | 7.69 | Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. ( Chang, LC; Kuo, SC; Raung, SL; Wang, JP, 1995) |
| " Oedema formation induced by intradermal capsaicin has been studied in rabbit skin." | 7.69 | An investigation into the mechanism of capsaicin-induced oedema in rabbit skin. ( Brain, SD; Newbold, P, 1995) |
| ") inhibits rat paw oedema induced by platelet activating factor (PAF), while LC and ALC, as well as indomethacin and phenylbutazone, are ineffective." | 7.69 | Protective effect of propionyl-L-carnitine against PAF-induced rat paw oedema. ( Amico-Roxas, M; Caruso, A; Cutuli, VM; De Bernardis, E; Leonardi, G, 1995) |
| " The main purpose of this work was to verify IAA's topical anti-inflammatory action using croton oil- or arachidonic acid-induced mouse ear edema, in comparison to known anti-inflammatory agents." | 7.69 | Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema. ( Abdalla, DS; Freitas, JC; Jones, LH, 1995) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 7.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| " We have investigated the mechanism of capsaicin-induced mouse ear oedema compared with that of arachidonic acid (AA)-induced ear oedema, and evaluated the possible involvement of neuropeptides in the development of capsaicin-induced oedema." | 7.68 | Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema. ( Inoue, H; Koshihara, Y; Nagata, N, 1993) |
| "The potential efficacy of indomethacin (a potent inhibitor of endogenous prostaglandin synthesis) on spinal cord-evoked potentials and edema formation occurring after a focal trauma to the spinal cord was examined in a rat model." | 7.68 | Indomethacin, an inhibitor of prostaglandin synthesis attenuates alteration in spinal cord evoked potentials and edema formation after trauma to the spinal cord: an experimental study in the rat. ( Olsson, Y; Sharma, HS; Stålberg, E; Winkler, T, 1993) |
| " velutina on arachidonic acid (AA)-induced ear oedema in mice." | 7.68 | Extract and compounds obtained from Mandevilla velutina inhibit arachidonic acid-induced ear oedema in mice, but not rat stomach contraction. ( Calixto, JB; Cruz, AB; Medeiros, YS; Yunes, RA; Zanini Júnior, JC, 1991) |
| "Indomethacin lessens edema after repetitive cerebral ischemia, suggesting that elevations of cyclooxygenase products are responsible, at least in part, for severe brain edema following repetitive ischemia." | 7.68 | Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. ( Betz, AL; Deluga, KS; Plötz, FB, 1991) |
| " Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test." | 7.68 | Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin. ( Gard, PR; Trigger, DJ, 1990) |
| "The time course of the paw oedema induced by the subplantar injection of carrageenan was studied in rats treated neonatally with capsaicin and in their vehicle-treated controls." | 7.67 | Effect of neonatal treatment with capsaicin on carrageenan-induced paw oedema in the rat. ( Donnerer, J; Gamillscheg, A; Holzer, P; Lembeck, F, 1984) |
| "We have found that mouse ear oedema induced by the topical application of arachidonic acid is not a specific screen for compounds inhibiting the lipoxygenase or cyclo-oxygenase pathways of arachidonic acid metabolism." | 7.67 | Inhibition of arachidonic acid-induced ear oedema as a model for assessing topical anti-inflammatory compounds. ( Boyle, EA; Crummey, A; Harper, GP; Mangan, FR, 1987) |
| "Morphine inhibited the oedema formation induced by carrageenan." | 7.67 | Morphine inhibits the carrageenan-induced oedema and the chemoluminescence of leucocytes stimulated by zymosan. ( Budavári, I; Fürst, S; Gyires, K; Molnár, I, 1985) |
| "The influence of feeding a marine oil (MaxEPA) with a high content of eicosapentaenoic acid (EPA) to rats for 10 weeks on the development of carrageenin oedema was studied." | 7.67 | Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2. ( Juan, H; Sametz, W, 1985) |
| " In vivo, ebselen is a weak oral inhibitor of carrageenan paw oedema and adjuvant arthritis in the rat, differentiating it from classical NSAIDs such as indomethacin and diclofenac." | 7.67 | Ebselen: a new approach to the inhibition of peroxide-dependent inflammation. ( Kuhl, P; Leyck, S; Parnham, MJ; Schalkwijk, J; van den Berg, WB, 1987) |
| "The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated." | 7.67 | Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986) |
| "Edema formation and prostanoid production (prostaglandin E2 (PGE2), thromboxane B2 (TXB2), and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were studied in a model of neoplastic epidural cord compression (NSCC) in rats harboring a thoracolumbar tumor." | 7.67 | Indomethacin and dexamethasone treatment in experimental neoplastic spinal cord compression: Part 2. Effect on edema and prostaglandin synthesis. ( Shapira, Y; Shohami, E; Siegal, T, 1988) |
| "SA96 in combination with indomethacin or prednisolone was investigated for their effects on the adjuvant arthritis in Lewis rats." | 7.67 | [Pharmacological studies of N-(2-mercapto-2-methylpropanoyl)-L-cysteine (SA96). V. Effects of SA96 in combination with indomethacin or prednisolone on adjuvant arthritis in rats]. ( Hayashi, M; Iso, T; Kasamatsu, S; Mibu, H; Nakata, K; Yamauchi, H, 1985) |
| "With the carrageenin food oedema assay, we studied in rats the effects of indomethacin on inflammation, gastric ulcers and lipid peroxide levels." | 7.67 | Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats. ( Planas, JM; Puig-Parellada, P, 1985) |
| "The effectiveness of intramuscular indomethacin was compared with that of hydrocortisone succinate for the control of edema resulting from experimentally induced surgical trauma in rats." | 7.66 | Effect of indomethacin on postsurgical edema in rats. ( Amin, MM; Engel, MB; Laskin, DM, 1983) |
| "The effect of ethanol on the anti-inflammatory actions of indomethacin was studied using carrageenan-induced edema in the paw of the rat as the test for acute inflammation." | 7.66 | Indomethacin-ethanol interactions on acute inflammation. ( Greizerstein, HB, 1983) |
| "The influence of insulin, tolbutamide and buformin on the effect of indomethacin as measured in the carrageenan paw edema assay in Sprague-Dawley rats has been studied." | 7.66 | Potentiation of insulin and tolbutamide of the effect of indomethacin on carrageenan paw edema in the rat. ( Bor, P; Koltai, M; Szekeres, L; Wellinger, K, 1982) |
| " Mepyramine maleate at a dose maximally effective on histamine-induced paw oedema (1 mg X kg-1 i." | 7.66 | Re-appraisal of the role of histamine in carrageenan-induced paw oedema. ( Al-Haboubi, HA; Zeitlin, IJ, 1983) |
| "In patients treated with oral indomethacin for four weeks after intracapsular cataract extraction, five of 57 eyes (9%) had cystoid macular edema four to six weeks postoperatively as shown by fluorescein angiography." | 7.66 | The effect of indomethacin pretreatment on aphakic cystoid macular edema. ( Katzin, HM; Klein, RM; Yannuzzi, LA, 1979) |
| "The antiphlogistic activity of meseclazone and its major metabolite, 5-chlorosalicylic acid, have been directly compared to acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in rat paw edema induced by eleven different phlogistic agents." | 7.66 | Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models. ( Sofia, RD, 1978) |
| "Topically administered indomethacin was found to reduce the occurrence of cystoid macular edema after lens extraction." | 7.65 | Prevention of cystoid macular edema after lens extraction by topical indomethacin (I). A preliminary report. ( Miyake, K, 1977) |
| "Indomethacin is a known inhibitor of prostaglandin synthesis." | 6.65 | Indomethacin as a means of preventing cystoid macular edema following intracapsular cataract extraction. ( Frank, KE; Reinhart, WJ; Sholiton, DB, 1979) |
| "Icariin was injected in a dose of 50 mg/kg." | 5.51 | Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways. ( Eid, BG; El-Shitany, NA, 2019) |
| "Sclareol (1) is a natural fragrance compound used widely in the cosmetic and food industries." | 5.38 | Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model. ( Huang, GJ; Pan, CH; Wu, CH, 2012) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 5.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "Pretreatment with indomethacin, a cyclooxygenase inhibitor, also inhibited the carrageenin-induced responses significantly in normal rats." | 5.31 | Evidence for bradykinin mediation of carrageenin-induced inflammatory pain: a study using kininogen-deficient Brown Norway Katholiek rats. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "Hind-paw hyperalgesia was detected in arthritic rats from the 10th to the 16th day of observation." | 5.29 | Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. ( Carvalho, WM; Ferreira, SH; Francischi, JN; Miranda, AE; Silva, CV; Tatsuo, MA, 1994) |
| "Treatment with diphenhydramine completely prevented the increases in lymph flow, lymph total protein concentration, total protein transport, weight and vasodilation produced by infusions of histamine, but not those produced by infusions of prostaglandin E1 or bradykinin." | 5.26 | Pharmacological modification of the edema produced by combined infusions of prostaglandin E1 and bradykinin in canine forelimbs. ( Adamski, SW; Grega, GJ; Prasad, CM; Svensjö, E, 1982) |
| "Indomethacin was moderately effective in treating Basedow's ophthalmopathy." | 5.26 | [Long-term indomethacin treatment of ophthalmopathies after Basedow disease in general practice]. ( Amemiya, T, 1982) |
| "Oedema was measured after the challenging injection." | 5.26 | Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs. ( Arrigoni-Martelli, E; Bramm, E; Dieppe, PA; Huskisson, EC; Willoughby, DA, 1976) |
| "The effects of topical indomethacin and clobetasol propionate on erythema and oedema following low-dose cryotherapy to normal skin were examined using a single-blind technique." | 5.08 | The effects of topical indomethacin and clobetasol propionate on post-cryotherapy inflammation. ( Humphreys, F; Spiro, J, 1995) |
| "We conducted a prospective, double-masked, controlled study to determine the effects of indomethacin in preventing the development of cystoid macular edema after retinal detachment surgery." | 5.05 | Incidence of cystoid macular edema after retinal detachment surgery and the use of topical indomethacin. ( Asakura, M; Maekubo, K; Manabe, R; Miyake, K; Miyake, Y, 1983) |
| "A prospective double-masked study of 500 patients was performed to assess the effect of topical indomethacin on the angiographic incidence of cystoid macular edema (CME) in patients undergoing intraocular lens implant surgery." | 5.05 | Prophylaxis of pseudophakic cystoid macular edema with topical indomethacin. ( Jampol, LM; Kraff, MC; Lieberman, HL; Peyman, GA; Sanders, DR, 1982) |
| "A prospective, controlled study utilizing topical 1% aqueous indomethacin was employed in an attempt to determine the incidence of aphakic cystoid macular edema (ACME) following cataract surgery." | 5.05 | Incidence of aphakic cystoid macular edema with the use of topical indomethacin. ( Landau, AN; Turtz, AI; Yannuzzi, LA, 1981) |
| "A controlled, double-masked study in which patients with cystoid macular edema of more than four months' duration were treated with indomethacin failed to demonstrate a significant visual improvement when compared to patients who were treated with placebo." | 5.04 | Ineffectiveness of indomethacin in the treatment of chronic cystoid macular edema. ( Cohen, N; Katiz, I; Klein, RM; Wallyn, RH; Yannuzzi, LA, 1977) |
| " Anti-inflammatory activity was carried carrageenan-induced paw edema model in which indomethacin was used as standard and analgesic activity was evaluated by eddy's hot plate method using diclofenac as standard drug." | 4.12 | Water Mediated One-Pot, Stepwise Green Synthesis, Anti-Inflammatory and Analgesic Activities of (3-Amino-1-Phenyl-1H-Benzo[f]Chromen-2-yl) (1H-Indol-3-yl) Methanone Catalysed by L-Proline. ( Reddy, BS; Reddy, CVR; Reddy, GG, 2022) |
| "Paw edema was attenuated following the administration of indomethacin-loaded polymeric micelles." | 4.02 | Indomethacin loaded dextran stearate polymeric micelles improve adjuvant-induced arthritis in rats: design and in vivo evaluation. ( Abdollahi, AR; Firouzian, F; Haddadi, R; Nourian, A, 2021) |
| "In the present study, milnacipran showed anti-nociceptive and anti-inflammatory effects on carrageenan-induced hyperalgesia and inflammation in a dose-dependent manner." | 3.96 | Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress. ( Haddadi, R; Rashtiani, R, 2020) |
| " With a highly extended half-life of ∼40 h in rabbit eyes following intravitreal administration, the bicyclic peptides are promising novel agents for the treatment of diabetic retinopathy and diabetic macular edema." | 3.88 | Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema. ( Barbeaux, P; Bennett, G; Feyen, JHM; Harrison, H; Hu, TT; Le Floch, F; Pavan, S; Stace, C; Teufel, DP; Van Bergen, T; van Rietschoten, K; Vanhove, M; Vermassen, E, 2018) |
| " Using paw edema as the experimental model and different chemical mediators (prostaglandin and dextran), it was observed that both derivatives were active in comparison with both negative (5% Tween® 80 in saline) and positive (indomethacin) controls." | 3.85 | In vivo and in silico anti-inflammatory mechanism of action of the semisynthetic (-)-cubebin derivatives (-)-hinokinin and (-)-O-benzylcubebin. ( Andriani, KF; Bastos, JK; Borges, A; Borges, CHG; Caramori, GF; Conforti, VA; Cunha, WR; da Silva Laurentiz, R; de Andrade, CQJ; E Silva, MLA; Januário, AH; Lima, TC; Lucarini, R; Parreira, RLT; Pauletti, PM; Símaro, GV; Souza, AMP; Volpe, AC, 2017) |
| " The compounds were evaluated for their anti-inflammatory activity in carrageenan induced rat paw edema model taking rofecoxib and indomethacin as standard drugs." | 3.85 | Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect. ( Bali, A; Chaudhari, BB; Sharma, R, 2017) |
| "Group containing indomethacin-loaded nanocapsules (NC) presented lower edema in the right hind paw at 24h after formalin injection than those of the control group (CT) (P<0." | 3.85 | Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules. ( Cioato, SG; Collares, FCM; da Silva Torres, IL; de Freitas, JS; Ferreira, MBC; Genari, B; Guterres, SS; Leitune, VCB; Medeiros, LF; Pohlmann, AR; Samuel, SMW, 2017) |
| "Pre-treatment with RC produced a dose-dependent reduction in carrageenan-induced paw edema and CFA-induced arthritis models and was effective as indomethacin." | 3.85 | Anti-inflammatory and anti-arthritic activity of aqueous extract of Rosa centifolia in experimental rat models. ( Gupta, YK; Kumar, R; Nair, V; Singh, S, 2017) |
| "To examine the effect of koumine, a Gelsemium alkaloid, on two experimental models of rheumatoid arthritis (RA), rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) were administered koumine (0." | 3.83 | Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats. ( Cai, HD; Chen, ZH; Fang, MH; Huang, HH; Su, YP; Xu, Y; Yang, J; Yu, CX; Zeng, YL, 2016) |
| " Furthermore, the anti-inflammatory effect of the extract in rats for two different test models: carrageenan and histamine-induced paw edema was inspected." | 3.83 | HPLC profiling, antioxidant and in vivo anti-inflammatory activity of the ethanol extract of Syzygium jambos available in Bangladesh. ( Akbar, PN; Hossain, H; Jahan, IA; Khan, TA; Rahman, MM; Rahman, SE, 2016) |
| " Materials and methods Analgesic and anti-inflammatory activities of ISA were evaluated using writhing, hot plate, xylene-induced ear oedema, carrageenan-induced paw oedema and cotton pellets-induced granuloma test, meanwhile the prostaglandin E2 (PGE2) and malondialdehyde (MDA) levels were assessed in the oedema paw tissue." | 3.83 | Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid. ( Dong, K; Sun, JY; Xing, JF; You, CY; You, HS, 2016) |
| " In this study, a series of novel thiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives bearing naproxen was synthesized and evaluated for their in vivo analgesic and anti-inflammatory properties in acute experimental pain and inflammation models." | 3.81 | Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies. ( Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A, 2015) |
| " The cyclo-oxygenase inhibitor indomethacin partially inhibited knee oedema and allodynia but did not affect the leukocyte influx, myeloperoxidase activity or impaired motion in the kaolin-injected rat." | 3.81 | Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats. ( Camargo, LL; Costa, SK; Denadai-Souza, A; Fernandes, E; Grant, A; Lima, C; Mesquita, FP; Muscará, MN; Schenka, A; Soares, AG; Yshii, LM, 2015) |
| " Xylene-induced ear edema, carrageenan-induced paw edema and acetic acid-induced vascular permeability test were used to investigate the anti-inflammatory activities of GL in mice." | 3.81 | Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice. ( Li, YX; Ma, L; Niu, Y; Niu, YT; Shi, GJ; Sun, T; Wang, HL; Wu, J; Yu, JQ; Zheng, J, 2015) |
| " All the compounds were evaluated for their anti-inflammatory (carrageenan-induced rat paw edema assay), antioxidant (inhibition of lipid peroxidation) and antiulcer activity (indomethacin-induced gastric damage)." | 3.81 | Synthesis, Structure Activity Relationship (SAR), and Biological Activities of Benzylideneacetophenones Derivatives. ( Choudhary, AN; Juyal, V; Kumar, A, 2015) |
| " Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin." | 3.80 | 1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2014) |
| "86% inhibition of edema at 5h) in comparison to celecoxib (51." | 3.80 | Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors. ( Grover, J; Jachak, SM; Kumar, V; Sobhia, ME, 2014) |
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 3.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| " Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin." | 3.79 | New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2013) |
| " The anti-inflammatory activity of 1a-h was investigated by acute carrageenan-induced paw edema in mice using the reference drug indomethacin." | 3.79 | Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties. ( Al-Tabakha, MM; Caproiu, MT; Fahelelbom, KM; Limban, C; Missir, AV; Sadek, B, 2013) |
| " Most of the prepared compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared with indomethacin." | 3.78 | Synthesis, anti-inflammatory activity and ulcerogenic liability of novel nitric oxide donating/chalcone hybrids. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Farag, HH; Mourad, MA, 2012) |
| "A series of 3-alkoxy-4-methanesulfonamido acetophenone derivatives were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model." | 3.78 | Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents. ( Bali, A; Deb, PK; Ohri, R, 2012) |
| " After synthesis and screening, three of (2a, 2c, 3a) revealed potent anti-inflammatory activity exceeding that of indomethacin, the reference inhibitor for artificially induced edema in rats." | 3.78 | Computer-assisted rational design, synthesis, and bioassay of non-steroidal anti-inflammatory agents. ( Girgis, AS; Katritzky, AR; Oliferenko, AA; Oliferenko, PV; Tala, SR, 2012) |
| " The oral administration of the Chantaleela recipe reduced ulcer formation in acute gastric ulcer models (EtOH/HCl-, indomethacin-, and stress-induced gastric lesions)." | 3.78 | Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe. ( Jaijoy, K; Khonsung, P; Nanna, U; Piyabhan, P; Sireeratawong, S; Soonthornchareonnon, N, 2012) |
| " The analgesic activity was examined against oxytocin-induced dysmenorrhea in mice." | 3.78 | Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. ( Chen, T; Duan, JA; Gu, W; Hua, Y; Jiang, H; Su, S; Tang, Y; Wang, Y; Zhou, W, 2012) |
| "We investigated the effect of argirein on acute inflammation edema and examined that aquaporin 4 (AQP4), p66Shc and activating transcription factor (ATF-6) might be involved in carrageenan-induced rat paw inflammation and be reversed by argirein, rhein and indometacin, but not L-arginine." | 3.78 | Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| "This study reports a pharmacological evaluation of anti-inflammatory and anti-ulcer activities of carvacrol, a phenolic monoterpene constituent of essential oils produced by oregano and other several aromatic plants and spices, in experimental models of edema induced by different phlogistic agents and gastric lesions induced by acetic acid." | 3.78 | Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano. ( Arcanjo, DD; Guimarães, AG; Machado, FD; Oliveira, FA; Oliveira, RC; Quintans-Júnior, LJ; Silva, ER; Silva, FV; Sousa-Neto, BP, 2012) |
| "7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain." | 3.77 | Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin. ( Barbosa Filho, JM; Couto, RD; de Lima, FO; Nonato, FR; Nunes, XP; Ribeiro dos Santos, R; Soares, MB; Villarreal, CF, 2011) |
| " The compound 14d induced equipotent inhibition against rat paw edema, which is very close to the effect produced by the commonly used standard, namely indomethacin (47%)." | 3.77 | Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity. ( Georgikopoulou, K; Hadjipavlou-Litina, D; Mavromoustakos, T; Michas, G; Moutevelis-Minakakis, P; Neophytou, N; Papavassilopoulou, E; Ragoussi, ME; Zoumpoulakis, P, 2011) |
| "60 μmol/cm²) exhibited topical antiedematous properties comparable to those of indomethacin (ID₅₀ 0." | 3.77 | Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. ( Atanasov, AG; Bauer, J; Bauer, R; Baumgartner, L; Bodensieck, A; Dirsch, VM; Fakhrudin, N; Favero, GD; Heiss, EH; Ladurner, A; Loggia, RD; Ponti, C; Rollinger, JM; Schwaiger, S; Sosa, S; Stuppner, H; Tubaro, A; Werz, O; Widowitz, U, 2011) |
| " With the adjuvant arthritis model, the prophylactic efficacy profile of ABC294640 was similar to indomethacin." | 3.77 | Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. ( Donahue, H; Fitzpatrick, LR; Frauenhoffer, EE; French, KJ; Green, C; Maines, LW; Mosher, TJ; Paul, E; Smith, CD; Upson, JJ; Zhuang, Y, 2011) |
| " While the analgesic activity was examined against thermally and chemically induced nociceptive pain in mice, using the acetic acid and hot-plate test methods." | 3.77 | Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha. ( Duan, JA; Hua, YQ; Qian, DW; Su, S; Tang, YP; Wang, T; Yu, L; Zhou, W, 2011) |
| "Anti-inflammatory and antioxidative potential of hesperidin and naringin was carried out considering the rat air pouch model of inflammation." | 3.77 | Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. ( Jain, M; Parmar, HS, 2011) |
| " Acitretin and its analogs 5-7, 10, 11 and 15 inhibited lipid peroxidation more strongly than trolox whereas acitretin and analog 4 were in vivo more potent anti-inflammatory agents on rat paw oedema induced by Carrageenan than indomethacin." | 3.76 | Syntheses and evaluation of the antioxidant activity of acitretin analogs with amide bond(s) in the polyene spacer. ( Hadjipavlou-Litina, D; Krokidis, M; Magoulas, GE; Papaioannou, D, 2010) |
| " Derivatives 4a, 4b and 4c exhibited moderate to good anti-inflammatory and analgesic activity in carrageenan-induced rat paw edema and acetic acid-induced writhing in mice, respectively, with low ulcerogenicity compared with the standard drug indomethacin." | 3.76 | Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents. ( Gaba, M; Gaba, P; Sharma, V; Singh, D; Singh, S, 2010) |
| " The anti- oedema effect was compared with indomethacin." | 3.76 | Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum. ( Antonisamy, P; Ignacimuthu, S, 2010) |
| "To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema." | 3.76 | Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats. ( Hajhashemi, V; Minaiyan, M; Movahedian, A; Sadeghi, H; Talebi, A, 2010) |
| ") were assessed using acetic acid-induced vascular permeability, carrageenan-induced paw edema, and croton oil-induced ear edema." | 3.76 | The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo. ( Cho, YB; Hur, J; Jung, I; Jung, KC; Kang, JY; Kang, M; Kim, KS; Kim, SH; Lee, JD; Lee, JH; Park, DS; Yoo, MC, 2010) |
| " Results showed that 1-acylated-5-amino-1,2,4-triazole-3-acetates 3a-e showed higher anti-inflammatory activity than the corresponding 5-acylamino derivatives 4a-e in carageenan-induced rat paw edema test with low gastric ulcerogenicity compared with indomethacin." | 3.75 | Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity. ( Abdel-Megeed, AM; Abdel-Rahman, HM; Alkaramany, GE; El-Gendy, MA, 2009) |
| " The prepared compounds were evaluated for their anti-inflammatory activity using carrageenan-induced rat paw edema and compared to a well-known NSAID, indomethacin as a reference drug." | 3.75 | Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives. ( Abdel-Aziz, M; Aly, OM; Farag, HH; Morsy, MA; Shoman, ME, 2009) |
| " Anti-inflammatory activity screening of the synthesized compounds 2a-f,h; 3a-d (at a dose of 50mg/kg of body weight) utilizing in vivo acute carrageenan-induced paw oedema standard method in rats exhibited that many of the tested compounds reveal considerable anti-inflammatory properties, especially 2e and f which reveal remarkable activities relative to indomethacin (which was used as a reference standard at a dose of 10mg/kg of body weight)." | 3.75 | Facile synthesis of bis(4,5-dihydro-1H-pyrazole-1-carboxamides) and their thio-analogues of potential PGE(2) inhibitory properties. ( Barsoum, FF; Girgis, AS, 2009) |
| " The combined anti-inflammatory data from in vitro animal model showed that compounds, 9,11-dibromo-1-(2-furyl)-3-(4-tolyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 23, 9,11-dibromo-1-(4-methoxy-phenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 24, 9,11-dibromo-1-(4-chloro-phenyl)-3-(4-tolyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 29 and 9-bromo-1-(4-chloro-phenyl)-3-(4-tolyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one 36 exhibited even more potent anti-inflammatory activity and low gastric ulceration incidence compare to reference standard Indomethacin." | 3.75 | A new therapeutic approach in Parkinson's disease: some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents. ( Bhatnagar, SP; Laddha, SS, 2009) |
| " The analgesic activity of the test compounds was determined by phenylbenzoquinone-induced writhing assay and the anti-inflammatory activity was evaluated by the carrageenan-induced rat paw edema model." | 3.75 | Synthesis and analgesic and anti-inflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives. ( Colak, MS; Gökçe, M; Küpeli, E; Sahin, MF, 2009) |
| " Groups (N = 6-8) were submitted to right or left paw edema (PE) with carrageenan (100 microg) or Dextran (200 microg), hemorrhagic cystitis with ifosfamide (200 mg/kg, ip) or gastric injury (GI) with indomethacin (20 mg/kg, vo)." | 3.75 | Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats. ( Gomes, AS; Loiola, RT; Ribeiro, RA; Rocha, EL; Simão, AF; Souza Filho, MV; Souza, MH, 2009) |
| " The most potent compound, namely TRX derivative 3, was studied for its anti-inflammatory activity in vivo on rat paw edema induced by carrageenan, and was found to be of almost identical activity to indomethacin." | 3.75 | Trioxsalen derivatives with lipoxygenase inhibitory activity. ( Athanassopoulos, CM; E Bariamis, S; Hadjipavlou-Litina, D; Militsopoulou, M; Papaioannou, D, 2009) |
| "This paper describes the pharmacological evaluation pertaining to antinociceptive (hot plate and tail flick) and antiinflammatory (based on Carrageenan-induced paw oedema) activities, and QSAR studies on 2-substituted-4,5-diphenyl-1H-imidazoles." | 3.74 | Antinociceptive and antiinflammatory activities and QSAR studies on 2-substituted-4,5-diphenyl-1H-imidazoles. ( Doble, M; Puratchikody, A, 2007) |
| " All the target compounds showed anti-inflammatory activity and three of them 3b, 3c and 4c surpassed that of indomethacin both locally and systemically in the cotton pellet granuloma and rat paw edema bioassay." | 3.74 | Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. ( Abdel Ghany, YS; Ashour, HM; Baraka, A; Bekhit, AA; Bekhit, Ael-D, 2008) |
| " The methanol extract had a significant topical anti-inflammatory activity (ID 50, dose inducing 50% edema inhibition = 780 microg/cm (2)) about 8 times less than that of indomethacin (ID 50, 93 microg/cm (2)) assayed by the croton oil ear test in mice." | 3.74 | Isoprenoid glycosides from Liriosma ovata. ( Aquino, R; Mencherini, T; Piccinelli, A; Picerno, P; Rastrelli, L, 2008) |
| "The anti-inflammatory activity of an ethanolic extract of Carica papaya leaves was investigated in rats using carrageenan induced paw oedema, cotton pellet granuloma and formaldehyde induced arthritis models." | 3.74 | Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. ( Adebukola, OM; Funmilayo, AA; Owoyele, BV; Soladoye, AO, 2008) |
| "In this study the effects of compound B1, bis(3-aryl-3-oxo-propyl)methylamine hydrochloride, and an anti-inflammatory drug, indomethacin, were tested by carrageenan-induced paw edema and cotton pellet granuloma tests, for effects on acute and chronic phases of inflammation, respectively." | 3.74 | Anti-inflammatory activity of bis(3-aryl-3-oxo-propyl)methylamine hydrochloride in rat. ( Alkan, M; Gocer, F; Gul, HI; Gul, M; Suleyman, H, 2007) |
| " Model one was based on observed potent inhibitory activity against carrageenan-induced hind paw oedema and the second model used was acetic acid-induced, increased vascular permeability model." | 3.74 | Flavonoids with anti-inflammatory and antinociceptive activity from Cistus laurifolius L. leaves through bioassay-guided procedures. ( Küpeli, E; Yesilada, E, 2007) |
| " Compounds were evaluated for their analgesic (acetic acid-induced mouse abdominal constrictions, hot-plate test, formalin-induced pain test) and some of them for the anti-inflammatory activities (carrageenan-induced rat paw edema test)." | 3.74 | Antinociceptive profile of 2,3,6-trisubstituted piperidine alkaloids: 3-O-acetyl-spectaline and semi-synthetic derivatives of (-)-spectaline. ( Alexandre-Moreira, MS; Barreiro, EJ; Bolzani, Vda S; de Miranda, AL; Fraga, CA; Viegas, C, 2008) |
| "The anti-inflammatory activity of melatonin (CAS 73-31-4) was examined, using the rat paw edema model, and compared with the non-steroidal anti-inflammatory drug (NSAID) indometacin (CAS 53-86-1) which exerts its effects by inhibition of prostaglandin production on acute inflammation." | 3.74 | Structural basis of the anti-inflammatory activity of melatonin. ( Aguilar, CF; de la Rocha, N; Pelzer, L; Rotelli, A, 2007) |
| " It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects." | 3.74 | Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice. ( Itabashi, T; Kawai, K; Takido, M; Yasukawa, K, 2008) |
| " However, the role of LXA4 and aspirin (ASA)-triggered lipoxins (ATLs) in inflammatory edema formation remains unclear." | 3.73 | Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. ( Calixto, JB; Henriques, Md; Kassuya, CA; Menezes-de-Lima, O; Nascimento, AF, 2006) |
| " Following the unilateral intraplantar injection of BmK venom into rat hind paw, it was found: 1) BmK venom induced an edematogenic response, spontaneous pain and pain hypersensitivity in a dose-dependent manner; 2) the paw edema and flare were induced rapidly and restricted at the injected paw for about 24-48 h; 3) the monophasic tonic spontaneous pain manifested as continuous paw flinching and lifting/licking of the injected paw and lasted for more than 2 h; 4) the detectable thermal hypersensitivity to radiant heat stimuli was just at the injected side for about 72-96 h; 5) the mechanical hypersensitivity to von Frey filaments was evoked surprisingly to be the bilateral and mirror-like for about 2-3 weeks; 6) morphine, indomethacin and bupivacaine could suppress BmK venom-induced pain responses with different intensity and time courses." | 3.73 | Rat pain-related responses induced by experimental scorpion BmK sting. ( Bai, ZT; Chai, ZF; Ji, YH; Liu, T; Pang, XY, 2006) |
| "In the present study, we evaluated the consequences of prostaglandin E(2) (PGE(2)) or indomethacin injection into the spinal cord, on a model of peripheral inflammatory edema." | 3.72 | A spinal mechanism for the peripheral anti-inflammatory action of indomethacin. ( Daher, JB; Tonussi, CR, 2003) |
| " Azorellanol exhibited the highest topical anti-inflammatory potency on AA (arachidonic acid) and TPA (12-deoxyphorbol 13-tetradecanoate) induced oedema, and it effect was similar to the reference drugs (nimesulide and indomethacin)." | 3.72 | Pharmaco-toxicological study of diterpenoids. ( Backhouse, N; Bórquez, J; Delporte, C; Loyola, A; Salinas, P; San-Martín, A, 2003) |
| "In our study, the effects of the compound 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride (C1) and also an anti-inflammatory drug, indomethacin, tested by carrageenan-induced paw edema and cotton pellet granuloma tests, for their effects on acute and chronic phases of inflammation, respectively." | 3.72 | Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride. ( Asoglu, M; Gul, HI; Suleyman, H, 2003) |
| "The anti-inflammatory effect of the leaves of Bryonia laciniosa was evaluated using carrageenan, dextran, histamine, serotonin induced rat paw oedema and cotton pellet induced granuloma (chronic) models in rats." | 3.72 | Evaluation of anti-inflammatory activity of chloroform extract of Bryonia laciniosa in experimental animal models. ( Gupta, M; Karki, SS; Manikandan, L; Mazumdar, UK; Sambathkumar, R; Sivakumar, T; Vamsi, ML, 2003) |
| "The effect of valeryl salicylate (VS), an inhibitor of cyclooxygenase-1 (COX-1), was evaluated in arachidonic acid or croton oil-induced ear oedema and carrageenan-induced paw oedema in mice." | 3.72 | Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice. ( Brum-Fernandes, AJ; Peters, RR; Ribeiro-do-Valle, RM; Siqueira-Junior, JM, 2003) |
| "Combining allopurinol with either diclofenac or indomethacin produced synergistic inhibitory action on rat's paw edema." | 3.72 | Interaction of allopurinol and non-steroidal anti-inflammatory drugs on the carrageenan-induced rat paw edema. ( Al-Arfaj, AS; Al-Dalaan, AN; Alballa, SR; Mustafa, AA; Tuwaijri, AS, 2003) |
| " The carrageenan-induced paw edema, cotton pellet granuloma and indomethacin-induced gastric damage models were used to determine these effects." | 3.72 | Anti-inflammatory and antiulcerogenic effects of the aqueous extract of Lobaria pulmonaria (L.) Hoffm. ( Aslan, A; Bayir, Y; Cakir, A; Gocer, F; Halici, M; Karagoz, Y; Odabasoglu, F; Süleyman, H, 2003) |
| "Mouse ear edema induced with croton oil was inhibited significantly by dexamethasone and indomethacin at the dose of 10 mg." | 3.72 | [Inhibition of dexamethasone, indomethacin and resveratrol on matrix metalloproteinase-9 and the mechanism of inhibition]. ( Bai, JY; Cheng, GF; Li, YT; Shen, F, 2003) |
| "The anti-inflammatory activity of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), was studied on the carrageenan-induced paw inflammation in the rat." | 3.72 | Studies on the anti-inflammatory effect of fluoxetine in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR, 2004) |
| "In this study, amide derivatives of [6-(5-methyl-3-phenyl-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were synthesized and tested for their in vivo analgesic and anti-inflammatory activity by using the p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively." | 3.72 | Amide derivatives of [6-(5-methyl-3-phenylpyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acids as potential analgesic and anti-inflammatory compounds. ( Akoğlu, C; Banoglu, E; Küpeli, E; Sahin, MF; Unlü, S; Yeşilada, E, 2004) |
| "In conscious rats celecoxib, indomethacin and acetylsalicylic acid significantly reduced the paw oedema induced by carrageenan." | 3.72 | Gastric effects of the selective cyclooxygenase-2 inhibitor, celecoxib, in the rat. ( Coppelli, G; Coruzzi, G; Guaita, E; Spaggiari, S, 2004) |
| "5-2 mg per ear), reduced ear edema induced by arachidonic acid (AA) and phorbol myristate acetate (PMA, ED50 = 1." | 3.72 | In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG). ( Delgado, R; Delporte, C; García, D; Garrido, G; González, D; Lemus, Y; Lodeiro, L; Núñez-Sellés, AJ; Quintero, G, 2004) |
| " Pretreatment with p-chlorophenylalanine, indomethacin, ibuprofen, and nimodipine attenuated the SCEP changes immediately after trauma and resulted in a marked reduction in edema formation, BSCB permeability, and blood flow changes at 5 h." | 3.71 | Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat. ( Sharma, HS; Winkler, T, 2002) |
| "The tachykinin neurokinin B (NKB) has been implicated in the hypertension that characterises pre-eclampsia, a condition where tissue oedema is also observed." | 3.71 | Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms. ( Akhtar, R; Brain, SD; Gerard, NP; Grant, AD, 2002) |
| "The objectives of this study were to evaluate the anti-inflammatory effects and possible drug interactions of butorphanol by using carrageenan-induced paw inflammation in rats." | 3.71 | Butorphanol decreases edema following carrageenan-induced paw inflammation in rats. ( Moreau, JP; Vachon, P, 2002) |
| "This study evaluates the action of celecoxib and rofecoxib, two selective cyclooxygenase-2 (COX-2) inhibitors in two acute models of inflammation, carrageenan (Cg)-induced rat pleurisy, and paw oedema formation." | 3.71 | Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. ( Calixto, JB; Pinheiro, RM, 2002) |
| " Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited DMBA-induced inflammation and local immunosuppression." | 3.71 | Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2. ( Horio, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Tanaka, K; Urade, Y, 2001) |
| " Pre-treatment with the extract (100, 200 and 400 mg/kg) produced a significant and dose-dependent inhibition to the acute gastric ulcers induced by phenylbutazone, indomethacin, 0." | 3.71 | Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats. ( Al-Attas, A; Chan, K; Chen, HB; Islam, MW; Ismail, A; Liu, XM; Radhakrishnan, R; Zakaria, MN, 2001) |
| "The topical anti-inflammatory activity of a germacrane derivative [1,4-dihydroxy-germacra-5E-10(14)-diene; DHGD] isolated from Achillea pannonica Scheele (Asteraceae) was investigated employing the Croton oil-induced dermatitis in the mouse ear." | 3.71 | Topical anti-inflammatory activity of a new germacrane derivative from Achillea pannonica. ( Della Loggia, R; Glasl, S; Jurenitsch, J; Kastner, U; Sosa, S; Tubaro, A, 2001) |
| "The mechanism of action of FR140423 (3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)-phenyl]pyrazole), a novel and selective cyclooxygenase (COX)-2 inhibitor, in rat type II collagen-induced arthritis was investigated and compared with that of indomethacin." | 3.71 | Anti-inflammatory activity of a novel selective cyclooxygenase-2 inhibitor, FR140423, on type II collagen-induced arthritis in Lewis rats. ( Goto, T; Ochi, T, 2001) |
| " The antiinflammatory activity of synthetic cannabinoid nabilone in the rat model of carrageenan-induced acute hindpaw inflammation was compared with that of the endocannabinoid palmitoylethanolamide and the nonsteroidal antiinflammatory drug indomethacin." | 3.71 | Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. ( Colleoni, M; Conti, S; Costa, B; Giagnoni, G; Parolaro, D, 2002) |
| " The effects of C-1 on the acute phase of inflammation were studied in formaldehyde-induced edema." | 3.71 | An investigation of the antiinflammatory effects of an extract from Cladonia rangiformis HOFFM. ( Aslan, A; Gepdiremen, A; Göçer, F; Güvenalp, Z; Süleyman, H; Yildirim, D, 2002) |
| " The most potent PLA2 inhibitor, FMA, was tested in the mouse carrageenan paw edema at the oral dose of 10 mg/kg and showed an activity similar to the reference antiinflammatory drug, indomethacin." | 3.70 | Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues. ( Alcaraz, MJ; De Rosa, M; Giordano, S; Pastor, PG; Payá, M; Scettri, A; Sodano, G; Soriente, A, 1998) |
| " The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay." | 3.70 | Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole. ( Barreiro, EJ; Fraga, CA; Lages, AS; Miranda, AL; Silva, KC, 1998) |
| " All these compounds proved to be effective against 12-O-tetradecanoylphorbol-13-acetate-induced ear edema in mice, although lacking activity against arachidonic acid-induced edema." | 3.70 | A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa. ( Gil, I; Giner, RM; Gómez, C; Máñez, S; Recio, MC; Ríos, JL; Waterman, PG, 1999) |
| " In this work, ointments made from the same extract and three different excipients (vaseline, lanoline and shea butter (crude and refined)) have been prepared and tested by the method of the croton oil inhibited ear oedema." | 3.70 | [Inflammatory ointment from shea butter and hydro-alcoholic extract of Khaya senegalensis barks (Cailcederat)]. ( Ahodikpe, D; Dieng, M; Diop, AB; Lo, I; Ngom, S; Thioune, O, 2000) |
| " In carrageenin-induced paw edema, ER-34122 (3-100 mg/kg) and indomethacin (1-10mg/kg) were orally administered 1 h before carrageenin injection." | 3.70 | ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model. ( Chiba, K; Horizoe, T; Kobayashi, N; Kobayashi, S; Nagakura, N; Numata, H; Okamoto, Y; Shinoda, M; Shirota, H, 1998) |
| " induced by acetic acid and the fever elicited by baker's yeast." | 3.70 | Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. ( Endo, M; Fujii, E; Hohsho, H; Muraki, T; Shiba, N; Shibuya, H; Tokunaga, Y; Wada, K; Yoshioka, T, 1998) |
| " The topical anti-inflammatory effect of the chloroform extract from Achillea ageratum (Asteraceae) and of stigmasterol and beta-sitosterol, isolated of this extract has been evaluated, against to 12-0-tetradecanoylphorbol acetate (TPA)-induced mouse ear edema, using simple (acute model) and multiple applications (chronic model) of the phlogistic agent." | 3.70 | Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models. ( Fernández, MA; García, MD; Gómez, MA; Sáenz, MT, 1999) |
| " In the present study, therefore, we used the non-steroidal anti-inflammatory drugs indomethacin and sodium salicylate in carrageenan-induced rat paw inflammation, in order to compare their anti-inflammatory action (determined as inhibition of edema) with their effects on the concentration of NGF in inflamed tissue." | 3.70 | Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw. ( Amann, R; Schuligoi, R, 2000) |
| " Both fangchinoline and tetrandrine showed anti-inflammatory effects on mouse ear edema induced by croton oil." | 3.70 | Anti-inflammatory effects of fangchinoline and tetrandrine. ( Chang, YK; Choi, HS; Chung, MW; Kim, HS; Kim, Y; Lim, HK; Min, KR, 2000) |
| "To prove that prostaglandin I2 (PGI2) is a major prostaglandin involved in bradykinin-induced exudation, we examined carrageenin- or bradykinin-induced paw edema in prostacyclin receptor-deficient mice (IPKO)." | 3.70 | Intrinsic prostacyclin contributes to exudation induced by bradykinin or carrageenin: a study on the paw edema induced in IP-receptor-deficient mice. ( Ikeda, Y; Murata, T; Naraba, H; Narumiya, S; Oh-ishi, S; Ueno, A; Ushikubi, F, 2000) |
| " Tested compounds have demonstrated a certain activity and stability to gastric hydrolysis, in particular two of them markedly reduced paw edema formation, even if slightly less effectively than indomethacin (reference compound, 5 mg/kg)." | 3.70 | Evaluation of analgesic and anti-inflammatory activity of novel beta-lactam monocyclic compounds. ( De Martino, G; Fusco, B; Lancelot, JC; Rocco, F; Saturnino, C; Saturnino, P, 2000) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 3.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| "Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice." | 3.69 | Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. ( Chang, LC; Kuo, SC; Raung, SL; Wang, JP, 1995) |
| " Oedema formation induced by intradermal capsaicin has been studied in rabbit skin." | 3.69 | An investigation into the mechanism of capsaicin-induced oedema in rabbit skin. ( Brain, SD; Newbold, P, 1995) |
| "As zymosan-induced arthritis in rats combines dual activation of early prostaglandin-dependent processes (edema, fever, pain) and IL-1 related effects on cartilage metabolism, we compared the respective influences of indomethacin (IMT) and dexamethasone (DEX) on its course." | 3.69 | Zymosan-induced arthritis in rats. II. Effects of anti-inflammatory drugs. ( Gegout, P; Gillet, P; Netter, P; Terlain, B, 1995) |
| ") inhibits rat paw oedema induced by platelet activating factor (PAF), while LC and ALC, as well as indomethacin and phenylbutazone, are ineffective." | 3.69 | Protective effect of propionyl-L-carnitine against PAF-induced rat paw oedema. ( Amico-Roxas, M; Caruso, A; Cutuli, VM; De Bernardis, E; Leonardi, G, 1995) |
| " Since the non-steroidal anti-inflammatory agents, indomethacin and aspirin, were inactive, cyclooxygenase products are not involved in the anaphylactic reaction in boosted or unboosted mice." | 3.69 | Involvement of leukotrienes in allergic inflammation in mice. ( Cordeiro, RS; Vargaftig, BB; Zuany-Amorim, C, 1994) |
| " In the Carrageenan-induced edema test in rat paw, the activity ranged from 28 to 47% for 3a-3d and 44 to 63% for 4a-4d, with indomethacin (10 mg/kg, p." | 3.69 | Anti-inflammatory activity of substituted 1,3,4-oxadiazoles. ( Hariprasad, V; Nargund, LV; Reddy, GR, 1994) |
| " The main purpose of this work was to verify IAA's topical anti-inflammatory action using croton oil- or arachidonic acid-induced mouse ear edema, in comparison to known anti-inflammatory agents." | 3.69 | Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema. ( Abdalla, DS; Freitas, JC; Jones, LH, 1995) |
| "Oxaceprol, an established therapeutic agent for osteoarthritis, had no effect on macrophage prostaglandin E2 release in vitro and inhibited carrageenan paw oedema at high doses (18-150 mg/kg p." | 3.69 | Oxaceprol, an atypical inhibitor of inflammation and joint damage. ( Brune, K; Ionac, M; Parnham, MJ; Plauchithiu, M, 1996) |
| " These models of acute and chronic inflammation, and the antimitotic model permitted us to evaluate the anti-inflammatory and antimitotic effects of sulindac, ibuprofen, naproxen and glucametacin." | 3.69 | Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque. ( Akatsu, T; Consolaro, A; Guimarães, SA; Tago, EM, 1996) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 3.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| "A series of benzobisthiazoles were screened for antiinflammatory activity in the carrageenan paw edema and adjuvant arthritis tests." | 3.68 | Bis basic substituted diaminobenzobisthiazoles as potential antiarthritic agents. ( Becker, R; Cullen, E; Freter, K; LeClerq, T; Possanza, G; Wong, HC, 1992) |
| "2 microM) and show excellent antiinflammatory potency in the mouse arachidonic acid ear edema model." | 3.68 | 2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity. ( Batt, DG; Galbraith, W; Harris, RR; Maynard, GD; Petraitis, JJ; Shaw, JE, 1990) |
| " Several members of this family were found to be potent, dual inhibitors of cyclooxygenase and 5-lipoxygenase pathways of arachidonic acid metabolism and to have in vivo antiinflammatory activity in the rat foot edema assay." | 3.68 | 1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity. ( Carty, TJ; Moore, PF; Mylari, BL; Zembrowski, WJ, 1990) |
| " Finally, these active inhibitors of 5-lipoxygenase inhibited arachidonic acid-induced mouse ear edema more than phenidone." | 3.68 | 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. ( Izumi, A; Matsumoto, H; Miki, T; Nihro, Y; Satoh, T; Sogawa, S; Ueda, H, 1993) |
| " We have investigated the mechanism of capsaicin-induced mouse ear oedema compared with that of arachidonic acid (AA)-induced ear oedema, and evaluated the possible involvement of neuropeptides in the development of capsaicin-induced oedema." | 3.68 | Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema. ( Inoue, H; Koshihara, Y; Nagata, N, 1993) |
| " In pleurisy induced by carrageenan in rats, there were increases in leukocytes, LTB4, thromboxane B2 (TxB2) and 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha) in the pleural fluid over 3 h." | 3.68 | Anti-inflammatory activities of Ph CL28A in rats in vivo. ( Antunes, E; Bakhle, YS; De Nucci, G; Hyslop, S; Santana, AC, 1993) |
| "The potential efficacy of indomethacin (a potent inhibitor of endogenous prostaglandin synthesis) on spinal cord-evoked potentials and edema formation occurring after a focal trauma to the spinal cord was examined in a rat model." | 3.68 | Indomethacin, an inhibitor of prostaglandin synthesis attenuates alteration in spinal cord evoked potentials and edema formation after trauma to the spinal cord: an experimental study in the rat. ( Olsson, Y; Sharma, HS; Stålberg, E; Winkler, T, 1993) |
| "The antiinflammatory activity of a new 14-membered macrolide antibiotic, roxithromycin, was evaluated in various rat models including carrageenan- and poly-L-arginine-induced hind-paw oedema, croton oil inflamed ear assay and polyester sponge granuloma." | 3.68 | Macrolide antibiotics as antiinflammatory agents: roxithromycin in an unexpected role. ( Agen, C; Blandizzi, C; Costa, M; Danesi, R; Del Tacca, M; Favini, P; Stacchini, B, 1993) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| " MPO was measured in the mouse ear after injection of interleukin-1 beta, in the rat paw after carrageenan-induced edema and in the lung of sensitized guinea pigs after ovalbumin inhalation." | 3.68 | Measurement of MPO activity as model for detection of granulocyte infiltration in different tissues. ( Szelenyi, I; Werner, U, 1992) |
| "Magnolol, isolated from Magnolia officinalis, inhibited mouse hind-paw edema induced by carrageenan, compound 48/80, polymyxin B and reversed passive Arthus reaction." | 3.68 | Anti-inflammatory and analgesic effects of magnolol. ( Chen, CC; Hsu, MF; Kuo, JS; Raung, SL; Teng, CM; Wang, JP, 1992) |
| " However, PACAP38 significantly potentiated bradykinin-induced oedema where it was approximately 100 fold more potent than VIP." | 3.68 | Pituitary adenylate cyclase activating polypeptide is a potent vasodilator and oedema potentiator in rabbit skin in vivo. ( Coughlan, M; Kajekar, R; Larkin, SW; Warren, JB; Williams, TJ, 1992) |
| "6MNA, the active metabolite of the nonacidic antiinflammatory drug nabumetone, was investigated using intravenous administration for effects on (1) carrageenan paw edema and gastric irritancy compared with either oral nabumetone or both oral and intravenous indomethacin when given acutely and (2) gastrointestinal irritancy when given in repeat dosing studies." | 3.68 | Antiinflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Comparative studies with indomethacin. ( Blower, PR; Gentry, C; Kelvin, AS; Melarange, R; Neil, C; O'Connell, C; Toseland, CD, 1992) |
| " Topically applied fuscoside (FSD) effectively inhibits phorbol myristate acetate (PMA)-induced edema in mouse ears at levels comparable with indomethacin over a 3." | 3.68 | Fuscoside: an anti-inflammatory marine natural product which selectively inhibits 5-lipoxygenase. Part I: Physiological and biochemical studies in murine inflammatory models. ( Jacobs, RS; Jacobson, PB, 1992) |
| "Interstitial fluid pressure (Pif) was measured in skin of pentobarbital-anesthetized rats during anaphylaxis toward dextran and after subdermal injection of histamine by using sharpened glass capillaries (tip diam 5-7 microns) connected to a servo-controlled counterpressure system." | 3.68 | Increased negativity of interstitial fluid pressure during the onset stage of inflammatory edema in rat skin. ( Reed, RK; Rodt, SA, 1991) |
| " Acetazolamide, ethoxzolamide, methazolamide, and dichlorphenamide reduced paw oedema and attenuated the deterioration of the joints of rats with adjuvant arthritis." | 3.68 | Carbonic anhydrase inhibitors are antiarthritic in the rat. ( Barrett, RJ; Gathright, CE; Nolan, JC; Radvany, CH; Sancilio, LF, 1991) |
| " velutina on arachidonic acid (AA)-induced ear oedema in mice." | 3.68 | Extract and compounds obtained from Mandevilla velutina inhibit arachidonic acid-induced ear oedema in mice, but not rat stomach contraction. ( Calixto, JB; Cruz, AB; Medeiros, YS; Yunes, RA; Zanini Júnior, JC, 1991) |
| "Indomethacin lessens edema after repetitive cerebral ischemia, suggesting that elevations of cyclooxygenase products are responsible, at least in part, for severe brain edema following repetitive ischemia." | 3.68 | Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. ( Betz, AL; Deluga, KS; Plötz, FB, 1991) |
| " In adjuvant arthritis, E5090 suppressed both the paw swelling and the enhancements of ESR and number of peripheral blood leucocytes, like the steroidal antiinflammatory drug prednisolone." | 3.68 | Antiinflammatory properties of E5090, a novel orally active inhibitor of IL-1 generation. ( Chiba, K; Goto, M; Hashida, R; Ono, H; Shirota, H, 1991) |
| "The steroid-saving activity of the highly potent new non-steroid antiinflammatory agent CGP 28238 was determined in rat carrageenin paw edema and in primary phase of adjuvant arthritis in comparison with indomethacin." | 3.68 | Steroid-saving potency of nonsteroidal antiinflammatory agents--a reevaluation with the new agent CGP 28238 in rat inflammatory models. ( Giessler, J; Hirschelmann, R; Pöch, G; Rafler, I; Rickinger, O, 1991) |
| " The inflammatory response induced by poly-L-arginine in the rat hind-paw was studied both by measuring paw oedema and histologically." | 3.68 | Pharmacological characterization of polycation-induced rat hind-paw oedema. ( Antunes, E; Cirino, G; de Nucci, G; Levi, S; Mariano, M, 1990) |
| " Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test." | 3.68 | Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin. ( Gard, PR; Trigger, DJ, 1990) |
| "To investigate the role of interleukin 6 (IL-6) in adjuvant-induced arthritis, serum from adjuvant-immunized Lewis rats treated with cyclosporin, indomethacin, or saline was evaluated for IL-6 activity." | 3.68 | Interleukin-6 serum levels correlate with footpad swelling in adjuvant-induced arthritic Lewis rats treated with cyclosporin A or indomethacin. ( Gaarde, WA; Leisten, JC; Scholz, W, 1990) |
| "Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a seleno-organic compound with glutathione peroxidase-like activity in vitro, was compared with indomethacin, BW 755C, and levamisole as an inhibitor of carrageenan- and CVF (cobra venom factor)-induced paw oedema in the rat." | 3.68 | Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen. ( Leyck, S; Parnham, MJ, 1990) |
| "The ethyl acetate extract and a fraction, KSE-23, isolated chromatographically from the ethyl acetate extract of Euphorbia prostrata, showed significant antiinflammatory activity when topically applied in a murine model of carrageenan footpad oedema." | 3.68 | Topical antiinflammatory effects of Euphorbia prostrata on carrageenan-induced footpad oedema in mice. ( Pathak, K; Singla, AK, 1990) |
| "Replacement of the carboxyl group of 2-(3-benzoylphenyl)propionic acid (Ketoprofen) with various bulky amines has produced a series of highly active antiinflammatory agents that have reduced intestinal ulcerogenicity and have better therapeutic ratios in the 21-day adjuvant arthritis assay in rats than currently marketed nonsteroidal antiinflammatory drugs." | 3.67 | Bulky amine analogues of ketoprofen: potent antiinflammatory agents. ( Behn, DC; Botton, I; Fellows, CA; Laskowski, SC; Phillips, DK; Schlegel, DC; Speight, PT; Zenitz, BL, 1984) |
| "The time course of the paw oedema induced by the subplantar injection of carrageenan was studied in rats treated neonatally with capsaicin and in their vehicle-treated controls." | 3.67 | Effect of neonatal treatment with capsaicin on carrageenan-induced paw oedema in the rat. ( Donnerer, J; Gamillscheg, A; Holzer, P; Lembeck, F, 1984) |
| "We have found that mouse ear oedema induced by the topical application of arachidonic acid is not a specific screen for compounds inhibiting the lipoxygenase or cyclo-oxygenase pathways of arachidonic acid metabolism." | 3.67 | Inhibition of arachidonic acid-induced ear oedema as a model for assessing topical anti-inflammatory compounds. ( Boyle, EA; Crummey, A; Harper, GP; Mangan, FR, 1987) |
| "The duration of pharmacological action in the rat (carrageenin edema inhibition) of a long-acting indomethacin form (Dolcidium PL) was compared to that of a reference long-acting indomethacin form after a single oral dose (3 mg/kg) considered as the ED50 value and compatible with clinical use." | 3.67 | Pharmacological activity, blood and tissue levels of indomethacin after single oral administration of two long-acting forms in the rat. ( Bianchi, A; Cazin, JC; Cazin, M; Chaoui, A; Paluszezak, D, 1989) |
| "Morphine inhibited the oedema formation induced by carrageenan." | 3.67 | Morphine inhibits the carrageenan-induced oedema and the chemoluminescence of leucocytes stimulated by zymosan. ( Budavári, I; Fürst, S; Gyires, K; Molnár, I, 1985) |
| "A topical preparation of meclofenamic acid (Meclomen) was tested for anti-inflammatory activity in a murine model of carrageenan footpad oedema." | 3.67 | The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice. ( Gilbertsen, RB; Gluckman, MI; Moniot, S; Schrier, DJ, 1987) |
| "Dipyrone blocked carrageenin-induced oedema and hyperalgesia in a dose-dependent manner." | 3.67 | Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia. ( Ferreira, SH; Lorenzetti, BB, 1985) |
| "The influence of feeding a marine oil (MaxEPA) with a high content of eicosapentaenoic acid (EPA) to rats for 10 weeks on the development of carrageenin oedema was studied." | 3.67 | Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2. ( Juan, H; Sametz, W, 1985) |
| " In vivo, ebselen is a weak oral inhibitor of carrageenan paw oedema and adjuvant arthritis in the rat, differentiating it from classical NSAIDs such as indomethacin and diclofenac." | 3.67 | Ebselen: a new approach to the inhibition of peroxide-dependent inflammation. ( Kuhl, P; Leyck, S; Parnham, MJ; Schalkwijk, J; van den Berg, WB, 1987) |
| "The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated." | 3.67 | Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986) |
| " Dexamethasone, but not indomethacin, BW755C, mepyramine or methysergide inhibited development of paw oedema; none of these drugs were effective in the pleurisy model." | 3.67 | Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. ( Peers, SH, 1988) |
| "Edema formation and prostanoid production (prostaglandin E2 (PGE2), thromboxane B2 (TXB2), and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were studied in a model of neoplastic epidural cord compression (NSCC) in rats harboring a thoracolumbar tumor." | 3.67 | Indomethacin and dexamethasone treatment in experimental neoplastic spinal cord compression: Part 2. Effect on edema and prostaglandin synthesis. ( Shapira, Y; Shohami, E; Siegal, T, 1988) |
| " The anti-inflammatory properties of FPP028 were evaluated through the carrageenan induced paw edema and the cotton pellet induced granuloma and compared with the activity of indomethacin, phenylbutazone, and isoxicam; as a result, the activity of FPP028 was shown to be similar to that of the latter compounds." | 3.67 | Pharmacological activity of FPP028 (2-phenylpyrazolo-4-ethyl-4,7-dihydro [1,5a]pyrimidin-7-one) a new non-steroid anti-inflammatory agent. ( Banchelli, G; Bianchini, F; Ignesti, G; Pecori-Vettori, L; Pirisino, R; Rafanelli, D; Raimondi, L, 1986) |
| "FUT-175 inhibited the zymosan-induced rat paw edema in a dose-dependent manner, while indomethacin exhibited no significant activities in this model." | 3.67 | Inhibitory effects of a novel synthetic protease inhibitor, FUT-175, on the paw edema in rats and zymosan-induced complement activation in vitro. ( Ino, Y; Iwaki, M; Koshiyama, Y; Motoyoshi, A; Oda, M; Sato, T, 1986) |
| "SA96 in combination with indomethacin or prednisolone was investigated for their effects on the adjuvant arthritis in Lewis rats." | 3.67 | [Pharmacological studies of N-(2-mercapto-2-methylpropanoyl)-L-cysteine (SA96). V. Effects of SA96 in combination with indomethacin or prednisolone on adjuvant arthritis in rats]. ( Hayashi, M; Iso, T; Kasamatsu, S; Mibu, H; Nakata, K; Yamauchi, H, 1985) |
| "The effect of topical clobetasol propionate and a 1% topical indomethacin gel which could inhibit UV erythema was measured on anthralin inflammation by change in skin-fold thickness and erythema." | 3.67 | Mechanism of anthralin inflammation. I. Dissociation of response to clobetasol and indomethacin. ( Lawrence, CM; Shuster, S, 1985) |
| "With the carrageenin food oedema assay, we studied in rats the effects of indomethacin on inflammation, gastric ulcers and lipid peroxide levels." | 3.67 | Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats. ( Planas, JM; Puig-Parellada, P, 1985) |
| " Three of the most active compounds (4, 18a, and 18e) were tested in the rat adjuvant arthritis model and found to be essentially equivalent in activity to indomethacin." | 3.66 | Glycerides as prodrugs. 3. Synthesis and antiinflammatory activity of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl]glycerides (indomethacin glycerides). ( Carter, GW; Cimon, DG; Garmaise, DL; Paris, GY; Swett, L; Young, P, 1980) |
| " Injected in the paw of the rat, polymorphonuclear leucocytes do not increase the oedematogen action of bradykinin, but increase the action of lambda carrageenan." | 3.66 | [Interaction of polymorphonuclear leukocytes, bradykinin and carragenin. Transference reaction in the rat]. ( Damas, J; Lismonde, M; Remacle-Volon, G, 1982) |
| " In the carrageenin test the activity of ONO-3144 was comparable to that of indomethacin (IM), while in the dextran, albumin, yeast and scald edema test it was more potent than that of IM." | 3.66 | ONO-3144, a new anti-inflammatory drug and its possible mechanism of action. ( Aishita, H; Miura, Y; Miyamoto, T; Mizushima, Y; Morimura, T; Obata, T; Tsuboshima, M, 1983) |
| "The effectiveness of intramuscular indomethacin was compared with that of hydrocortisone succinate for the control of edema resulting from experimentally induced surgical trauma in rats." | 3.66 | Effect of indomethacin on postsurgical edema in rats. ( Amin, MM; Engel, MB; Laskin, DM, 1983) |
| " Fenflumizole was comparable to or weaker than indomethacin in models of acute inflammation (carrageenin paw oedema and pleurisy, rats, ultraviolet erythema, guinea-pigs) and stronger than indomethacin as an analgesic (writhing, mice)." | 3.66 | Pharmacodynamics and toxicology of fenflumizole, a new non-steroidal anti-inflammatory imidazole derivative. ( Corell, T; Hasselmann, G, 1983) |
| "The effect of ethanol on the anti-inflammatory actions of indomethacin was studied using carrageenan-induced edema in the paw of the rat as the test for acute inflammation." | 3.66 | Indomethacin-ethanol interactions on acute inflammation. ( Greizerstein, HB, 1983) |
| "The influence of insulin, tolbutamide and buformin on the effect of indomethacin as measured in the carrageenan paw edema assay in Sprague-Dawley rats has been studied." | 3.66 | Potentiation of insulin and tolbutamide of the effect of indomethacin on carrageenan paw edema in the rat. ( Bor, P; Koltai, M; Szekeres, L; Wellinger, K, 1982) |
| " Mepyramine maleate at a dose maximally effective on histamine-induced paw oedema (1 mg X kg-1 i." | 3.66 | Re-appraisal of the role of histamine in carrageenan-induced paw oedema. ( Al-Haboubi, HA; Zeitlin, IJ, 1983) |
| " The topical application of NSAID ointment (1% of indomethacin, ketoprofen or diclofenac sodium) markedly inhibited the paw edema by carrageenin in rats." | 3.66 | [Evaluation of nonsteroidal anti-inflammatory drugs (NSAID) intended for use as topical anti-inflammatory drugs]. ( Kyuki, K, 1982) |
| " Carbon tetrachloride (1,0 ml/Kg, os) is able in depressing significantly the rat paw oedema provoked by carrageenan, but does not potentiates the anti-inflammatory action of non-steroid agents." | 3.66 | [Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents]. ( Curzio, M; Negro, F; Paradisi, L; Parola, M; Torrielli, MV, 1981) |
| " The anti-inflammatory activity of Indomethacin, Oxametacine and Phenylbutazone was evaluated in these animals using paw oedema provoked by carrageenan granulomas induced by cotton pellets and polyarthritis induced by Freund complete adjuvant." | 3.66 | The influence of experimental hypo- and hyperthyroid states on acute and chronic inflammatory reactions: modified response to non-steroidal anti-inflammatory agents. ( Cirillo, R; Curzio, M; Franzone, J; Sena, L; Torrielli, MV, 1981) |
| "In rats pretreated with indomethacin, injection of PGE1 (prostaglandin E1) with carrageenan potentiated the carrageenan paw oedema." | 3.66 | Characteristics of prostaglandin E1 potentiation of inflammatory activity of some agents. ( Thomas, G, 1980) |
| "In patients treated with oral indomethacin for four weeks after intracapsular cataract extraction, five of 57 eyes (9%) had cystoid macular edema four to six weeks postoperatively as shown by fluorescein angiography." | 3.66 | The effect of indomethacin pretreatment on aphakic cystoid macular edema. ( Katzin, HM; Klein, RM; Yannuzzi, LA, 1979) |
| "Effects of ketoprofen, indomethacin, phenylbutazone and acetylsalicylic acid on edema and on in vivo and in vitro synthesis of PGE1, PGE2 and PGF2 alpha in response to carrageenin were studied in rats." | 3.66 | Studies on the effects of anti-inflammatory action of benzoyl-hydrotropic acid (ketoprofen) and other drugs, with special reference to prostaglandin synthesis. ( Kawamoto, H; Komatsu, H; Kubota, T; Yamada, T, 1979) |
| "The antiphlogistic activity of meseclazone and its major metabolite, 5-chlorosalicylic acid, have been directly compared to acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in rat paw edema induced by eleven different phlogistic agents." | 3.66 | Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models. ( Sofia, RD, 1978) |
| " In the carrageenan edema test, eight compounds exhibited higher antiinflammatory activities than did indomethacin." | 3.65 | 6,11-Dihydro-11-oxodibenz [b,e] oxepinacetic acids with potent antiinflammatory activity. ( Kubo, S; Tagawa, H; Tsukada, W; Ueno, K; Yoshioka, T, 1976) |
| "Tilorone suppressed inflammation induced by immune (direct passive Arthus reaction) as well as by non-immune agents (carrageenam-induced paw edema and abscess formation), if the compound is given 24 hr prior to the proinflammatory agonists." | 3.65 | The anti-inflammatory actions of tilorone hydrochloride. ( Beaver, TH; Megel, H; Raychaudhuri, A; Shemano, I; Thomas, LL, 1975) |
| "Topically administered indomethacin was found to reduce the occurrence of cystoid macular edema after lens extraction." | 3.65 | Prevention of cystoid macular edema after lens extraction by topical indomethacin (I). A preliminary report. ( Miyake, K, 1977) |
| "Flumizole is a potent anti-inflammatory agent in animal models with an inhibitory activity severalfold that of indomethacin in rat foot edema and prostaglandin synthetase tests." | 3.65 | Flumizole, a new nonsteroidal anti-inflammatory agent. ( Bettis, JW; McIlhenny, HM; Wiseman, EH, 1975) |
| " In a rat paw edema test for anti-inflammatory activity naproxen was 55 times more active than aspirin." | 3.65 | Chemistry and pharmacology of naproxen. ( Dorfman, RI, 1975) |
| " Significant inhibition of oedema formation caused by thermal injury was observed for calcium carbaspirin, phenylbutazone, hydrocortisone, cryogenine and indomethacin when given daily beginning 2 days prior to thermal exposure and afterwards." | 3.65 | Evaluation of cryogenine on rat paw thermal oedema and rat isolated uterus. ( Malone, MH; Trottier, RW, 1973) |
| "gov NCT01747252) revealed relatively high bioavailability and two distinctly separated plasma concentration peaks at 1 and 5 h." | 2.79 | A novel red grape cells complex: health effects and bioavailability of natural resveratrol. ( Azachi, M; Danon, A; Hagay, Y; Katz, A; Yatuv, R, 2014) |
| "Acemetacin has shown that its analgesic, anti-inflammatory and antipyretic effects are equal to those of the reference substance, indometacin." | 2.65 | [Clinical trials with acemetacin on children and adolescents (author's transl)]. ( Neugirg, R; Penners, R, 1980) |
| "Indomethacin is a known inhibitor of prostaglandin synthesis." | 2.65 | Indomethacin as a means of preventing cystoid macular edema following intracapsular cataract extraction. ( Frank, KE; Reinhart, WJ; Sholiton, DB, 1979) |
| "Inflammation is a protective biological process, but under extreme conditions, it can become highly dreadful to the body." | 1.91 | Synthesis, Molecular Docking and ADME Prediction of 1H-indole/5- substituted Indole Derivatives as Potential Antioxidant and Anti- Inflammatory Agents. ( Kumari, A; Singh, RK, 2023) |
| "Indomethacin (10 mg/kg BW) was given orally as the standard drug." | 1.91 | Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation. ( Baro, MR; Das, B; Das, M; Kalita, A; Sarma, K, 2023) |
| " However, their long-term administration is associated with various side effects including gastrointestinal ulceration." | 1.72 | Nonacidic thiophene-based derivatives as potential analgesic and design, synthesis, biological evaluation, and metabolic stability study. ( El-Nassan, HB; Fahim, SH; Mahmoud, ST; Mikhail, DS, 2022) |
| "Rebamipide (REB) a potent anti-ulcer agent, has not been exploited to its full potential, owing to it extremely poor solubility, leading to highly diminutive bioavailability (<10%)." | 1.62 | Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies. ( Chadha, R; Dureja, J; Jindal, A; Karan, M; Singh, R; Tomar, S, 2021) |
| "Icariin was injected in a dose of 50 mg/kg." | 1.51 | Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways. ( Eid, BG; El-Shitany, NA, 2019) |
| "Most drugs used to treat pain and inflammation have potential side effects, which makes it necessary to search for new sources of bioactive molecules." | 1.48 | LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice. ( Alencar Filho, EB; Almeida, JRGDS; Barreiro, EJL; Diniz, TC; Lavor, ÉM; Lima, LM; Lima-Saraiva, SRG; Mendes, RL; Oliveira Júnior, RG; Silva, JC; Silva, MGE; Soares, JMD, 2018) |
| "This edema was significantly inhibited by ((S)1-{2-[3(3-4-dichlorophenyl)-1-(3-iso-propoxyphenylacetyl)piperidine-3-yl]ethyl}-4-phenyl-1-azoniabicyclo[2." | 1.43 | Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats. ( Antunes, E; Hyslop, S; Linardi, A; Rocha-E-Silva, TA, 2016) |
| "Because atherosclerosis is an inflammatory process involving a series of pathological events such as dyslipidemia, oxidative stress, and blood clotting mechanisms, we hereby report the synthesis and evaluation of novel compounds in which antioxidant, anti-inflammatory, and squalene synthase (SQS) inhibitory/hypolipidemic activities are combined in simple molecules through design." | 1.40 | Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity. ( Kourounakis, AP; Matralis, AN, 2014) |
| " The lead compound demonstrated very good oral bioavailability in mice, slow metabolic degradation, modest distribution into the brain and a remarkable anti-inflammatory efficacy in carrageenan-induced mouse paw edema model." | 1.40 | Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core. ( Gavalas, A; Geronikaki, A; Hammock, B; Hwang, SH; Iurchenko, V; Ivanenkov, Y; Krasavin, M; Morisseau, C; Mujumdar, P; Sarnpitak, P; Zozulya, S, 2014) |
| "Pain is the most common reason a patient sees a physician." | 1.40 | Antinociceptive properties of physalins from Physalis angulata. ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014) |
| " Histological examination revealed normal architecture and no significant adverse effects were observed on the liver, kidney, heart, lung or ovaries and testicles." | 1.40 | Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats. ( Bravo, J; Morales, G; Olivares, A; Paredes, A, 2014) |
| "The edema was produced in a dose- and time-dependent manner." | 1.39 | Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms. ( Laraba-Djebari, F; Sebia-Amrane, F, 2013) |
| "Sclareol (1) is a natural fragrance compound used widely in the cosmetic and food industries." | 1.38 | Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model. ( Huang, GJ; Pan, CH; Wu, CH, 2012) |
| " Furthermore, 5b could significantly suppress the progression of carrageenan-induced hind paw edema compared to indomethacin at a dosage of 10 mg/kg/day, and dose-dependently ameliorated the development of adjuvant-induced arthritis (AIA) validated by arthritic scores and H&E staining of joints." | 1.38 | Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents. ( Cao, D; Chen, J; Chen, L; Deng, C; Li, X; Liang, X; Ma, L; Peng, A; Peng, F; Qiu, J; Ran, Y; Wang, G; Wei, Y; Xiang, M; Xie, C; Yang, Z; Ye, H, 2012) |
| "We diagnosed late onset spondyloarthropathy according to clinic and radiographic findings." | 1.38 | Late onset spondyloarthropathy mimicking polymyalgia rheumatica. ( Altındağ, O; Aydeniz, A; Gürsoy, S; Oğüt, E, 2012) |
| "Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production." | 1.37 | Antinociceptive properties of bergenin. ( Couto, RD; David, JM; David, JP; de Lima, FO; de Oliveira, CM; Nonato, FR; Soares, MB; Villarreal, CF, 2011) |
| "The aspirin prodrug ( 23) was a 2." | 1.35 | Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies. ( Chen, QH; Citro, ML; Keefer, LK; Knaus, EE; Velázquez, CA, 2008) |
| "Hypertension was induced by DOCA-salt." | 1.35 | Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009) |
| "Cryptolepine has been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor-kappa B following inflammatory stimuli in vitro." | 1.35 | Anti-inflammatory properties of cryptolepine. ( Ajayi, AM; Olajide, OA; Wright, CW, 2009) |
| "Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model." | 1.35 | Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009) |
| "Treatment with Artepillin C decreased prostaglandin E(2) by 29+/-3% and 58+/-5% at 1 and 10 mg/kg, respectively, with a mean ID(50) of 8." | 1.35 | Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis. ( Abreu, SR; Bretz, WA; Dirsch, VM; Hori, H; Koyama, D; Nagasawa, H; Paulino, N; Scremin, A; Uto, Y; Vollmar, AM, 2008) |
| "Its role as a mediator of hyperalgesia (clinically defined as an augmented sensitivity to painful stimuli) is not known." | 1.35 | Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. ( Cuzzocrea, S; Di Paola, R; Esposito, E; Matuschak, GM; Mazzon, E; Ndengele, MM; Salvemini, D, 2008) |
| "Treatment with indomethacin (2 mg/kg), rofecoxib, (10 mg/kg), or dexamethasone (2 mg/kg) significantly reduced the BaV- and BjV-induced oedema formation." | 1.34 | Role of cyclooxygenases in oedema-forming activity of bothropic venoms. ( Gutierrez, JM; Olivo, Rdo A; Teixeira, CF; Wallace, JL; Zamuner, SR, 2007) |
| "Atopic dermatitis is a chronic inflammatory disease characterized by severe pruritus, and cutaneous barrier disruption by scratching contributes to further aggravation of the condition." | 1.34 | Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice. ( Arai, I; Futaki, N; Hashimoto, Y; Honma, Y; Nakaike, S; Sakurai, T; Sugimoto, M, 2007) |
| "Indomethacin is a non-steroidal anti-inflammatory drug but its use is associated with high degree of gastric toxicity therefore it is prescribed only in severe conditions." | 1.33 | Anti-inflammatory and gastro sparing activity of some new indomethacin derivatives. ( Amir, M; Kumar, S, 2005) |
| "The edema was inhibited by previous treatment with promethazine (5 or 10mg/kg) or cyproheptadine (5 or 10mg/kg), but not by indomethacin (2 or 4mg/kg), dexamethasone (1 or 4mg/kg) or cromolyn (40 or 80mg/kg)." | 1.33 | Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus. ( Bertollo, CM; Coelho, MM; Costa, KA; Glória, MB; Moraes-Santos, T; Nascimento, EB; Oliveira, AC; Rocha, LT; Souza, AL, 2005) |
| "NDGA significantly inhibited edema, hyperalgesia, and arthritis score in TRPV1+/+, but not in TRPV1-/- mice." | 1.33 | Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice. ( Bánvölgyi, A; Bite, A; Bölcskei, K; Elekes, K; Helyes, Z; Németh, J; Pintér, E; Sándor, K; Szabó, A; Szolcsányi, J, 2005) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 1.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "Pretreatment with indomethacin significantly attenuated the venom-induced responses and also blocked the paw oedema." | 1.33 | Intra-arterial injection of Mesobuthus tamulus venom elicits cardiorespiratory reflexes involving perivascular afferents. ( Deshpande, SB; Singh, SK, 2005) |
| "Indomethacin was less effective, though tissue prostaglandin E2 but not leukotriene B4 levels were reduced." | 1.33 | The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo. ( Andrews, G; Colville-Nash, P; Freemantle, C; Lam, C; Papworth, J; Willis, D; Willoughby, D, 2005) |
| "Mechanical hyperalgesia induced in rat paws by carrageenan (250microg) was modified by pre-treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib and SC236." | 1.33 | Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan. ( Bakhle, YS; Duarte, ID; Ferreira-Alves, DL; França, DS; Francischi, JN; Rezende, RM; Ribeiro, MC, 2006) |
| "Pretreatment with indomethacin completely reversed both of the therapeutic effects of dalteparin, whereas pretreatment with NS-398, a selective inhibitor of cyclooxygenase-2, did not." | 1.33 | Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats. ( Harada, N; Okajima, K; Uchiba, M, 2006) |
| "2% at 1 and 2h after dosing (P<0." | 1.32 | The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Shenawy, SM, 2003) |
| " The severity of the toxicity (macroscopic ulcerations) in the stomach following oral dosing with [Zn2(Indo)4(DMF)2] was not significantly lower than that induced by IndoH (P = 0." | 1.32 | Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin. ( Biffin, JR; Davies, NM; Dillon, CT; Hambley, TW; Kennedy, BJ; Lay, PA; Regtop, HL; Zhou, Q, 2003) |
| "Loratadine pretreatment, but neither guanethidine nor indomethacin, reduced edema." | 1.32 | Nociceptive and edematogenic responses elicited by a crude bristle extract of Lonomia obliqua caterpillars. ( de Castro Bastos, L; Guimarães, JA; Tonussi, CR; Veiga, AB, 2004) |
| "Hind paw edema was induced in male Wister rats by the subplantar injection of venom (12." | 1.32 | Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema. ( Bon, C; Cruz-Höfling, MA; Ferreira de Araújo, PM; Guimarães, AQ; Lôbo de Araújo, A, 2004) |
| " However, a number of facts involving the occurrence of gastrointestinal lesions have limited the chronic use of NSAIDs." | 1.32 | Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine. ( Cardoso, LG; Carvalho, JC; Ferreira, LR; Maciel, HP; Perazzo, FF, 2004) |
| " Both low- and high-frequency EA combined with INDO enhanced antihyperalgesia compared to each component alone, and 10 Hz but not 100 Hz EA significantly reduced CFA-induced hind paw edema." | 1.32 | Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats. ( Berman, BB; Lao, L; Ren, K; Wang, X; Zhang, RX, 2004) |
| "Acute inflammation was induced by sub-plantar injection of carrageenan (1%) in the rat hind paw." | 1.31 | Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Batran, S; El-Shenawy, SM, 2002) |
| "2." | 1.31 | Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation. ( Bakhle, YS; Chaves, CT; Ferreira-Alves, DL; Francischi, JN; Lima, AS; Moura, AC; Rocha, OA, 2002) |
| "Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited UV-induced ear swelling, abrogated local immunosuppression, and decreased the amount of PGE2 in the ear skin of XPA-deficient mice." | 1.31 | Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice. ( Eguchi, N; Horio, T; Inui, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Tanaka, K; Urade, Y, 2000) |
| " Pharmacodynamic evaluation of the liposomes was performed by carrageenan-induced rat paw edema (acute) and adjuvant arthritis (chronic) models." | 1.31 | Preparation and pharmacodynamic evaluation of liposomes of indomethacin. ( Diwan, PV; Srinath, P; Vyas, SP, 2000) |
| "The oedema has distinct borders to the surrounding connective tissue and is separated and removed easily for further analysis." | 1.31 | A new technique for the analysis of endogenous mediators released following thermal injury. ( Cassuto, J; Lindblom, L; Löwhagen, PH; Nilsson, U; Räntfors, J; Tarnow, P; Yregård, L, 2001) |
| "Pretreatment with indomethacin, a cyclooxygenase inhibitor, also inhibited the carrageenin-induced responses significantly in normal rats." | 1.31 | Evidence for bradykinin mediation of carrageenin-induced inflammatory pain: a study using kininogen-deficient Brown Norway Katholiek rats. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "Bothrops asper venom-induced hyperalgesia was blocked by the bradykinin B(2) receptor antagonist HOE 140 and attenuated by dexamethasone, an inhibitor of phospholipase A(2)." | 1.31 | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom. ( Chacur, M; Cury, Y; Gutiérrez, JM; Picolo, G; Teixeira, CF, 2001) |
| "Mibefradil treatment also caused a significant reduction of the polymorphonuclear leucocyte number in the paw tissue." | 1.31 | Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat. ( Akpinar, E; Altaş, S; Bilici, D; Bilici, S; Dengiz, GO; Gürsan, N, 2001) |
| "The relationship between the pharmacokinetic properties and the analgesic effect of indomethacin (IDM) was evaluated on a carrageenin-induced inflammation model in the rat." | 1.30 | Relationship between pharmacokinetics and the analgesic effect of indomethacin in the rat. ( Aoki, M; Hanano, M; Shimizu, R; Suganuma, T; Suzuki, T, 1997) |
| "Indomethacin was a potent inhibitor of both COX-1 (IC50 = 18 +/- 3 nM) and COX-2 (IC50 = 26 +/- 6 nM) under the same assay conditions." | 1.30 | Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. ( Boyce, S; Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Ethier, D; Evans, J; Falgueyret, JP; Ford-Hutchinson, AW; Gordon, R; Greig, G; Gresser, M; Guay, J; Kargman, S; Léger, S; Mancini, JA; O'Neill, G; Ouellet, M; Percival, MD; Riendeau, D; Rodger, IW; Thérien, M; Wang, Z; Webb, JK; Wong, E, 1997) |
| "The reasons for referral were hydrops (2), cardiomegaly (1), polyhydramnios and choroid plexus cyst (1), and polyhydramnios and teratoma of the neck (1)." | 1.30 | Isolated ductal closure in utero diagnosed by fetal echocardiography. ( Cavallé-Garrido, T; Farine, D; Heilbut, M; Leal, SD; Ryan, G; Smallhorn, JF, 1997) |
| "Pretreatment with indomethacin (10 mg kg[-1], s." | 1.30 | Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs. ( Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1997) |
| "In rats with yeast-induced hyperalgesia, JTE-522 showed a dose-dependent antinociceptive effect (ED50: 4." | 1.30 | Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats. ( Masaki, M; Matsushita, M; Tanaka, T; Wakitani, K; Yagi, Y, 1997) |
| "The thermal hyperalgesia was evident 20 min after injection and lasted less than 4 h." | 1.30 | Effect of colchicine on nerve growth factor-induced leukocyte accumulation and thermal hyperalgesia in the rat. ( Schuligoi, R, 1998) |
| "Oedema was induced by: a) AA (0." | 1.30 | Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation. ( González, R; Ledón, N; Romay, C, 1998) |
| " However, when animals were pre-treated with BCG, the dose-response curves for both B1 agonists were shifted 2 to 8-fold to the left." | 1.30 | Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice. ( Calixto, JB; de Campos, RO; Henriques, MG, 1998) |
| "Amentoflavone was also found to inhibit cyclooxygenase from guinea-pig epidermis without affecting lipoxygenase." | 1.30 | Amentoflavone, a plant biflavone: a new potential anti-inflammatory agent. ( Chang, HW; Kang, SS; Kim, HK; Kim, HP; Son, KH, 1998) |
| "Alminoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class." | 1.30 | Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway. ( Diab, N; Domage, G; Dray, F; Mace, JL; Raguenes-Nicol, C; Russo-Marie, F; Solito, E; Streichenberger, G, 1999) |
| "This inflammation was characterized by oedema and granulocyte infiltration." | 1.30 | Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. ( Hollenberg, MD; Sharkey, KA; Vergnolle, N; Wallace, JL, 1999) |
| "Rats with adjuvant arthritis were given daily oral dex (0." | 1.30 | Combination benefit of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) and dexamethasone or indomethacin in adjuvant arthritic rats. ( Bendele, AM; Chlipala, ES; Edwards, CK; Frazier, J; Gould, T; Kieft, G; McComb, J; Seely, J; Wolf, J, 1999) |
| "Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS)." | 1.29 | Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis. ( Jensen, MA; Reder, AT; Sapugay, AM; Thapar, M, 1994) |
| "carrageenin oedema and adjuvant arthritis." | 1.29 | Hyaluronic acid modulates acute and chronic inflammation. ( Di Rosa, M; Ialenti, A, 1994) |
| " and higher, and indometacin at a dosage of 2 mg/kg/d p." | 1.29 | Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid. ( Albrecht, W; Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Guserle, R; Laufer, S; Munt, PL; Tries, S, 1995) |
| "Pretreatment with indomethacin, 10 mg/kg s." | 1.29 | Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins. ( Marhuenda, E; Martín, MJ; Pérez Guerrero, C, 1994) |
| "Hind-paw hyperalgesia was detected in arthritic rats from the 10th to the 16th day of observation." | 1.29 | Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. ( Carvalho, WM; Ferreira, SH; Francischi, JN; Miranda, AE; Silva, CV; Tatsuo, MA, 1994) |
| "Only avarol was able to inhibit human recombinant synovial phospholipase A2 activity with an IC50 = 158 microM, and thus this compound showed a potency higher than that of mepacrine." | 1.29 | Avarol and avarone, two new anti-inflammatory agents of marine origin. ( Alcaraz, MJ; Bustos, G; De Rosa, S; Ferrándiz, ML; Payá, M; Sanz, MJ, 1994) |
| "Pretreatment with indomethacin (10 mg/kg, i." | 1.29 | Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: an experimental study in the rat. ( Dey, PK; Nyberg, F; Olsson, Y; Sharma, HS, 1993) |
| " These results suggested that the bioavailability of IND was increased by olive oil, fatty acid, and tristearin as absorbefacient agents." | 1.29 | Pharmacological and pharmaceutical properties of freeze-dried formulations of egg albumin, indomethacin, olive oil, or fatty acids. ( Kakegawa, H; Matsumoto, H; Miyataka, H; Satoh, T; Tsuji, Y, 1993) |
| "The edema was of a transient nature." | 1.28 | Differences in proinflammatory activity of several immunomodulatory derivatives of muramyl dipeptide (MDP) with special reference to the mechanism of the MDP effects. ( Zídek, Z, 1992) |
| " Thus, CP-331 exerted anti-inflammatory, analgesic, and antipyretic effects but without showing gastric toxicity, which is a common side effect of anti-inflammatory drugs." | 1.28 | Anti-inflammatory, analgesic, and antipyretic effects and gastrointestinal toxicity of the new anti-inflammatory drug N-(3-[3-(piperidinylmethyl)phenoxy]propyl)-carbamoylmethylthio ]ethyl 1-(p-chlorobenzoyl) 5-methoxy-2-methyl-3-indolylacetate. ( Abe, T; Itokazu, Y; Ohya, O; Omata, T; Segawa, Y; Tagashira, E; Tsuzuike, N; Ueda, I; Yoshida, K, 1992) |
| "Anthralin and UVB were then applied to the gel-treated skin and the anthralin- and UVB-induced erythema and oedema were measured at 2, 6, 24 and 48 h using Harpenden callipers and a reflectance erythrometer." | 1.28 | The effect of indomethacin on anthralin inflammation. ( Lawrence, C; Ramsay, B; Rice, N, 1992) |
| "Indomethacin was used as a reference." | 1.28 | Antinociceptive and anti-inflammatory activity of a novel quipazine derivative (AAL-13): a selective inhibitor of 5-hydroxytryptamine reuptake. ( Alhaider, AA; el-Mahdy, SA; Mahgoub, AA, 1990) |
| "Oedema was maximal within 1 h after BJV injection, was partially reduced at 6 h and disappeared completely within 24 h." | 1.28 | Pharmacological evaluation of rat paw oedema induced by Bothrops jararaca venom. ( Calixto, JB; Trebien, HA, 1989) |
| " No significant differences in anti-oedema activity were observed between the different preparations of indomethacin, but high blood levels of drug were observed following dosing with indomethacin, in a PEG 6000 melt." | 1.27 | The effect of incorporation of indomethacin with polyethylene glycol 6000 in a solid dispersion on its in vivo properties in the rat. ( Chan, KK; Elliott, PN; Ford, JL, 1984) |
| "aspirin were additive." | 1.27 | Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent. ( Holsapple, MP; Nichols, DE; Trizzino, J; Yim, GK, 1983) |
| "Saikogenin A was less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema." | 1.27 | Anti-inflammatory effect of saikogenin A. ( Cheng, JT; Tsai, CL, 1986) |
| "Treatment with indomethacin (10 mg/kg q 12 hr x 3) reduced both elevated water content and specific gravity values back to normal levels." | 1.27 | Indomethacin and dexamethasone treatment in experimental neoplastic spinal cord compression: Part 1. Effect on water content and specific gravity. ( Catane, R; Sandbank, U; Shapira, Y; Siegal, T, 1988) |
| " In contrast, auranofin administered to normal rats, in the same dosing regimen, did not affect interleukin production." | 1.27 | Effect of auranofin treatment on aberrant splenic interleukin production in adjuvant arthritic rats. ( Dimartino, MJ; Hanna, N; Lee, JC; Votta, BJ, 1987) |
| "025-16 micrograms/paw) were followed by a bell-shaped dose-response curve for oedema." | 1.27 | Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat. ( Castro, HC; Cordeiro, RS; Lima, MC; Martins, MA; Neto, F; Silva, PM; Vargaftig, BB, 1987) |
| " During the second phase, after 24 h, edema was more pronounced, presented a clear dose-response relationship and peaked at 72 h after injection." | 1.27 | Mouse paw edema. A new model for inflammation? ( Assreuy-Filho, J; Cordeiro, RS; Cunha, FQ; Flores, CA; Henriques, MG; Martins, MA; Silva, PM, 1987) |
| "Pretreatment with promethazine, phenylbutazone, methysergide and indomethacin resulted in a decrease in foot oedema." | 1.27 | Turpentine-induced acute inflammatory response in Gallus gallus: oedema, vascular permeability and effects of non-steroidal anti-inflammatory drugs. ( Böhm, GM; Ito, NM, 1986) |
| "A case of hydrops fetalis with intra-uterine death after premature closure of the ductus arteriosus because of inhibition of premature labour by the administration of indomethacin is presented." | 1.27 | Premature closure of the ductus arteriosus causing intra-uterine death. A case report. ( Coetzee, MJ; Franszen, S; Truter, PJ; van der Merwe, JV, 1986) |
| "The edema is spontaneously well reversible." | 1.27 | Edemagenic activity of aqueous form of muramyl dipeptide (MDP) in rats. ( Masek, K; Zídek, Z, 1985) |
| " The compounds of most interest, 18 and 28, were further tested in a model of adjuvant-induced arthritis; in this system, both compounds were active when dosed intraperitoneally but failed to produce significant activity when dosed orally at subtoxic doses." | 1.26 | Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues. ( Millonig, RC; Rovnyak, GC; Schwartz, J; Shu, V, 1982) |
| "Treatment with diphenhydramine completely prevented the increases in lymph flow, lymph total protein concentration, total protein transport, weight and vasodilation produced by infusions of histamine, but not those produced by infusions of prostaglandin E1 or bradykinin." | 1.26 | Pharmacological modification of the edema produced by combined infusions of prostaglandin E1 and bradykinin in canine forelimbs. ( Adamski, SW; Grega, GJ; Prasad, CM; Svensjö, E, 1982) |
| "4." | 1.26 | Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors. ( Ferreira, SH; Vargaftig, BB, 1981) |
| "Indomethacin was moderately effective in treating Basedow's ophthalmopathy." | 1.26 | [Long-term indomethacin treatment of ophthalmopathies after Basedow disease in general practice]. ( Amemiya, T, 1982) |
| "TAI-284 protected rabbits from sudden death caused by intravenous injection of arachidonic acid, but the activity was about one twentieth less than that of indomethacin." | 1.26 | [Anti-inflammatory property of 6-chloro-5-cyclohexyl-1-indancarboxylic acid (TAI-284) (author's transl)]. ( Fujimura, H; Kyuki, K; Nozaki, M; Tsurumi, K, 1977) |
| "Indomethacin was administered intravenously 30 minutes before the scald; RISA was injected intravenously 30 min before termination of the study." | 1.26 | Effect of inhibiting prostaglandin synthesis on edema formation and albumin leakage during thermal trauma in the rat. ( Brouhard, BH; Carvajal, HF, 1979) |
| " These results suggest that Y-8004 may make feasible a reduction in dosage or a withdrawal of the steroid prescription." | 1.26 | [Pharmacological studies of 2-(5H-(1)benzopyrano[2,3-b]pyridin-7-yl)propionic acid (Y-8004). (3) Its interaction with anti-inflammatory agents]. ( Foto, K; Imayoshi, T; Kadobe, Y; Maruyama, Y, 1977) |
| "Pre-treatment with indomethacin (2 mg/kg/i." | 1.26 | Relationship between oedema and plasma exudation in rat paw carrageenin inflammation. ( Ferreira, SH; Zanin, MT, 1978) |
| "Oedema was measured after the challenging injection." | 1.26 | Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs. ( Arrigoni-Martelli, E; Bramm, E; Dieppe, PA; Huskisson, EC; Willoughby, DA, 1976) |
| "Nordihydroguaiaretic acid inhibits prostaglandin (PG) biosynthesis in vitro (ID50=228 muM), with a slope of dose-response curve high (b=209) as compared with indomethacin (ID50=0." | 1.26 | Antioxidants as agents potentiating the antiinflammatory action of indomethacin. ( Cebo, B; Kieć-Dembińska, A; Krupińska, J; Mazur, J; Sobański, H, 1976) |
| " The very shallow dose-response curves for flurbiprofen compared with acetylsalicylic acid, especially in the mouse and the rat test systems, are not due to an unreliable or abnormal absorption, which suggests that in these species the mode of action of flurbiprofen is not identical with that of acetylsalicylic acid." | 1.25 | Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. ( Adams, SS; McCullough, KF; Nicholson, JS, 1975) |
| " Phenylbutazone, aspirin and indomethacin were all well absorbed after oral administration, and the resultant plasma drug concentrations were closely similar to those produced when the drugs were administered intraperitoneally." | 1.25 | Factors influencing the inhibitory action of anti-inflammatory drugs on carrageenin induced oedema. ( Green, AY; Green, D; Murray, PA; Wilson, AB, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 294 (33.87) | 18.7374 |
| 1990's | 148 (17.05) | 18.2507 |
| 2000's | 206 (23.73) | 29.6817 |
| 2010's | 188 (21.66) | 24.3611 |
| 2020's | 32 (3.69) | 2.80 |
| Authors | Studies |
|---|---|
| Clark, RL | 1 |
| Pessolano, AA | 1 |
| Witzel, B | 1 |
| Lanza, T | 1 |
| Shen, TY | 1 |
| Van Arman, CG | 1 |
| Risley, EA | 3 |
| Sprague, PW | 1 |
| Heikes, JE | 1 |
| Ackrell, J | 1 |
| Antonio, Y | 1 |
| Franco, F | 1 |
| Landeros, R | 1 |
| Leon, A | 1 |
| Muchowski, JM | 2 |
| Maddox, ML | 1 |
| Nelson, PH | 1 |
| Rooks, WH | 2 |
| Roszkowski, AP | 3 |
| Wallach, MB | 1 |
| Nagakura, M | 1 |
| Ota, T | 1 |
| Shimidzu, N | 1 |
| Kawamura, K | 1 |
| Eto, Y | 1 |
| Wada, Y | 3 |
| Ridge, DN | 1 |
| Hanifin, JW | 1 |
| Harten, LA | 1 |
| Johnson, BD | 1 |
| Menschik, J | 1 |
| Nicolau, G | 1 |
| Sloboda, AE | 1 |
| Watts, DE | 1 |
| Smith, CE | 1 |
| Williamson, WR | 1 |
| Cashin, CH | 1 |
| Kitchen, EA | 2 |
| Yoshioka, Y | 1 |
| Kitagawa, M | 1 |
| Oki, M | 1 |
| Kubo, S | 2 |
| Tagawa, H | 2 |
| Ueno, K | 2 |
| Tsukada, W | 2 |
| Tsubokawa, M | 1 |
| Kasahara, A | 1 |
| Aultz, DE | 4 |
| Helsley, GC | 3 |
| Hoffman, D | 2 |
| McFadden, AR | 3 |
| Lassman, HB | 2 |
| Yoshioka, T | 2 |
| Asselin, AA | 1 |
| Humber, LG | 2 |
| Dobson, TA | 1 |
| Komlossy, J | 1 |
| Wright, SW | 1 |
| Harris, RR | 3 |
| Collins, RJ | 2 |
| Corbett, RL | 1 |
| Green, AM | 1 |
| Wadman, EA | 1 |
| Batt, DG | 3 |
| Kuroda, T | 1 |
| Suzuki, F | 1 |
| Tamura, T | 1 |
| Ohmori, K | 1 |
| Hosoe, H | 1 |
| Safak, C | 1 |
| Erdogan, H | 2 |
| Palaska, E | 1 |
| Sunal, R | 2 |
| Duru, S | 1 |
| Cullen, E | 1 |
| Becker, R | 1 |
| Freter, K | 1 |
| LeClerq, T | 1 |
| Possanza, G | 1 |
| Wong, HC | 2 |
| Maynard, GD | 1 |
| Petraitis, JJ | 1 |
| Shaw, JE | 1 |
| Galbraith, W | 1 |
| Mylari, BL | 1 |
| Carty, TJ | 1 |
| Moore, PF | 1 |
| Zembrowski, WJ | 1 |
| Lazer, ES | 2 |
| Possanza, GJ | 2 |
| Graham, AG | 1 |
| Farina, PR | 1 |
| Galeazzi, E | 1 |
| Greenhouse, R | 1 |
| Guzmán, A | 1 |
| Peréz, V | 1 |
| Ackerman, N | 1 |
| Ballaron, SA | 1 |
| Rovito, JR | 1 |
| Tomolonis, AJ | 2 |
| Young, JM | 1 |
| Matteo, MR | 1 |
| Mobilio, D | 1 |
| Katz, AH | 1 |
| Demerson, CA | 1 |
| Hughes, P | 1 |
| Brigance, R | 1 |
| Conway, K | 1 |
| Shah, U | 1 |
| Williams, G | 1 |
| Labbadia, F | 1 |
| Hagmann, WK | 1 |
| Dorn, CP | 1 |
| Frankshun, RA | 1 |
| O'Grady, LA | 1 |
| Bailey, PJ | 1 |
| Rackham, A | 1 |
| Dougherty, HW | 1 |
| Rovnyak, GC | 1 |
| Millonig, RC | 2 |
| Schwartz, J | 1 |
| Shu, V | 1 |
| Schlegel, DC | 1 |
| Zenitz, BL | 1 |
| Fellows, CA | 1 |
| Laskowski, SC | 1 |
| Behn, DC | 1 |
| Phillips, DK | 1 |
| Botton, I | 1 |
| Speight, PT | 1 |
| Martin, LL | 1 |
| Setescak, LL | 1 |
| Spaulding, TC | 1 |
| Boettcher, I | 1 |
| Elger, W | 1 |
| Kirsch, G | 1 |
| Siegmund, F | 1 |
| Wachtel, H | 1 |
| Toja, E | 1 |
| Selva, D | 4 |
| Schiatti, P | 4 |
| Rachlin, S | 1 |
| Bramm, E | 2 |
| Ahnfelt-Rønne, I | 1 |
| Arrigoni-Martelli, E | 5 |
| Nagai, Y | 1 |
| Irie, A | 1 |
| Nakamura, H | 2 |
| Hino, K | 1 |
| Uno, H | 1 |
| Nishimura, H | 1 |
| Houlihan, WJ | 1 |
| Cooke, G | 1 |
| Van Bochoven, R | 1 |
| Perrine, J | 1 |
| Takesue, EI | 1 |
| Jukniewicz, E | 1 |
| Closse, A | 1 |
| Haefliger, W | 2 |
| Hauser, D | 2 |
| Gubler, HU | 2 |
| Dewald, B | 1 |
| Baggiolini, M | 1 |
| Paris, GY | 1 |
| Garmaise, DL | 1 |
| Cimon, DG | 1 |
| Swett, L | 1 |
| Carter, GW | 1 |
| Young, P | 1 |
| Li, JJ | 1 |
| Anderson, GD | 2 |
| Burton, EG | 1 |
| Cogburn, JN | 2 |
| Collins, JT | 1 |
| Garland, DJ | 1 |
| Gregory, SA | 3 |
| Huang, HC | 1 |
| Isakson, PC | 5 |
| Koboldt, CM | 4 |
| Sogawa, S | 1 |
| Nihro, Y | 1 |
| Ueda, H | 1 |
| Izumi, A | 1 |
| Miki, T | 1 |
| Matsumoto, H | 2 |
| Satoh, T | 2 |
| Martinez, J | 1 |
| Silván, AM | 1 |
| Abad, MJ | 1 |
| Bermejo, P | 1 |
| Villar, A | 1 |
| Söllhuber, M | 1 |
| Khanna, IK | 2 |
| Weier, RM | 2 |
| Yu, Y | 2 |
| Xu, XD | 1 |
| Koszyk, FJ | 2 |
| Collins, PW | 2 |
| Veenhuizen, AW | 2 |
| Perkins, WE | 2 |
| Casler, JJ | 1 |
| Masferrer, JL | 4 |
| Zhang, YY | 2 |
| Seibert, K | 5 |
| De Rosa, M | 1 |
| Giordano, S | 1 |
| Scettri, A | 1 |
| Sodano, G | 1 |
| Soriente, A | 1 |
| Pastor, PG | 1 |
| Alcaraz, MJ | 3 |
| Payá, M | 3 |
| Lages, AS | 1 |
| Silva, KC | 1 |
| Miranda, AL | 1 |
| Fraga, CA | 3 |
| Barreiro, EJ | 4 |
| Friesen, RW | 1 |
| Brideau, C | 2 |
| Chan, CC | 2 |
| Charleson, S | 3 |
| Deschênes, D | 1 |
| Dubé, D | 1 |
| Ethier, D | 2 |
| Fortin, R | 1 |
| Gauthier, JY | 2 |
| Girard, Y | 1 |
| Gordon, R | 4 |
| Greig, GM | 1 |
| Riendeau, D | 2 |
| Savoie, C | 1 |
| Wang, Z | 2 |
| Wong, E | 3 |
| Visco, D | 1 |
| Xu, LJ | 1 |
| Young, RN | 1 |
| Song, Y | 2 |
| Connor, DT | 2 |
| Doubleday, R | 2 |
| Sorenson, RJ | 2 |
| Sercel, AD | 2 |
| Unangst, PC | 2 |
| Roth, BD | 2 |
| Gilbertsen, RB | 3 |
| Chan, K | 3 |
| Schrier, DJ | 3 |
| Guglietta, A | 2 |
| Bornemeier, DA | 2 |
| Dyer, RD | 2 |
| Beylin, VG | 1 |
| Padrón, JM | 1 |
| Martin, VS | 1 |
| Hadjipavlou-Litina, D | 14 |
| Noula, C | 1 |
| Constantinou-Kokotou, V | 2 |
| Peters, GJ | 1 |
| Kokotos, G | 1 |
| Máñez, S | 4 |
| Recio, MC | 5 |
| Gil, I | 1 |
| Gómez, C | 1 |
| Giner, RM | 5 |
| Waterman, PG | 1 |
| Ríos, JL | 4 |
| Kalgutkar, AS | 1 |
| Crews, BC | 1 |
| Rowlinson, SW | 1 |
| Marnett, AB | 1 |
| Kozak, KR | 1 |
| Remmel, RP | 1 |
| Marnett, LJ | 1 |
| Inagaki, M | 1 |
| Tsuri, T | 1 |
| Jyoyama, H | 1 |
| Ono, T | 1 |
| Yamada, K | 2 |
| Kobayashi, M | 1 |
| Hori, Y | 1 |
| Arimura, A | 1 |
| Yasui, K | 1 |
| Ohno, K | 1 |
| Kakudo, S | 1 |
| Koizumi, K | 1 |
| Suzuki, R | 1 |
| Kawai, S | 1 |
| Kato, M | 1 |
| Matsumoto, S | 1 |
| Huff, RM | 1 |
| Xu, X | 1 |
| Yuan, J | 1 |
| Yang, DC | 1 |
| Shin, SS | 2 |
| Noh, MS | 2 |
| Byun, YJ | 1 |
| Choi, JK | 3 |
| Kim, JY | 2 |
| Lim, KM | 2 |
| Ha, JY | 1 |
| Kim, JK | 2 |
| Lee, CH | 2 |
| Chung, S | 2 |
| Almansa, C | 1 |
| de Arriba, AF | 1 |
| Cavalcanti, FL | 1 |
| Gómez, LA | 1 |
| Miralles, A | 1 |
| Merlos, M | 1 |
| García-Rafanell, J | 1 |
| Forn, J | 1 |
| Delgado, G | 1 |
| del Socorro Olivares, M | 1 |
| Chávez, MI | 1 |
| Ramírez-Apan, T | 1 |
| Linares, E | 1 |
| Bye, R | 1 |
| Espinosa-García, FJ | 1 |
| Cardoso, CR | 1 |
| de Brito, FC | 1 |
| da Silva, KC | 1 |
| de Miranda, AL | 2 |
| Magrioti, V | 1 |
| Talla, E | 1 |
| Njamen, D | 2 |
| Mbafor, JT | 1 |
| Fomum, ZT | 2 |
| Kamanyi, A | 1 |
| Mbanya, JC | 2 |
| Kamo, T | 1 |
| Asanoma, M | 1 |
| Shibata, H | 1 |
| Hirota, M | 1 |
| Pal, M | 2 |
| Madan, M | 2 |
| Padakanti, S | 1 |
| Pattabiraman, VR | 1 |
| Kalleda, S | 1 |
| Vanguri, A | 1 |
| Mullangi, R | 1 |
| Mamidi, NV | 1 |
| Casturi, SR | 2 |
| Malde, A | 1 |
| Gopalakrishnan, B | 1 |
| Yeleswarapu, KR | 1 |
| Yankep, E | 1 |
| Fotsing, MT | 1 |
| Kontogiorgis, CA | 2 |
| Hadjipavlou-Litina, DJ | 6 |
| Byun, Y | 1 |
| Lee, KW | 1 |
| Moh, JH | 1 |
| Jeong, YS | 1 |
| Choi, YH | 1 |
| Koh, HJ | 1 |
| Park, YH | 1 |
| Oh, YI | 1 |
| Rios, MY | 1 |
| Aguilar-Guadarrama, AB | 1 |
| Zheng, X | 1 |
| Oda, H | 1 |
| Takamatsu, K | 1 |
| Sugimoto, Y | 1 |
| Tai, A | 1 |
| Akaho, E | 1 |
| Ali, HI | 1 |
| Oshiki, T | 1 |
| Kakuta, H | 1 |
| Sasaki, K | 1 |
| Puratchikody, A | 1 |
| Doble, M | 1 |
| Perissutti, E | 1 |
| Fiorino, F | 1 |
| Renner, C | 1 |
| Severino, B | 1 |
| Roviezzo, F | 1 |
| Sautebin, L | 2 |
| Rossi, A | 2 |
| Cirino, G | 3 |
| Santagada, V | 1 |
| Caliendo, G | 1 |
| Ukiya, M | 2 |
| Akihisa, T | 3 |
| Yasukawa, K | 5 |
| Tokuda, H | 2 |
| Suzuki, T | 4 |
| Kimura, Y | 3 |
| Girgis, AS | 7 |
| Mishriky, N | 1 |
| Ellithey, M | 1 |
| Hosni, HM | 1 |
| Farag, H | 1 |
| Elmegeed, GA | 1 |
| Baiuomy, AR | 4 |
| Abdel-Salam, OM | 6 |
| Detsi, A | 2 |
| Bouloumbasi, D | 1 |
| Prousis, KC | 1 |
| Koufaki, M | 2 |
| Athanasellis, G | 1 |
| Melagraki, G | 2 |
| Afantitis, A | 2 |
| Igglessi-Markopoulou, O | 2 |
| Kontogiorgis, C | 3 |
| Matsumoto, K | 1 |
| Seino, K | 1 |
| Nakamoto, K | 1 |
| Kuninaga, H | 1 |
| Koike, K | 1 |
| Takahashi, A | 1 |
| Bekhit, AA | 3 |
| Ashour, HM | 1 |
| Abdel Ghany, YS | 1 |
| Bekhit, Ael-D | 1 |
| Baraka, A | 1 |
| Salgin-Gökşen, U | 1 |
| Gökhan-Kelekçi, N | 2 |
| Göktaş, O | 2 |
| Köysal, Y | 1 |
| Kiliç, E | 1 |
| Işik, S | 1 |
| Aktay, G | 2 |
| Ozalp, M | 1 |
| Di Braccio, M | 3 |
| Grossi, G | 3 |
| Roma, G | 2 |
| Piras, D | 2 |
| Mattioli, F | 1 |
| Gosmar, M | 1 |
| Pontiki, E | 3 |
| Yabanoğlu, S | 1 |
| Küpeli, E | 6 |
| Salgin, U | 1 |
| Ozgen, O | 1 |
| Uçar, G | 1 |
| Yeşilada, E | 4 |
| Kendi, E | 1 |
| Yeşilada, A | 1 |
| Bilgin, AA | 1 |
| Chandrika, PM | 1 |
| Yakaiah, T | 1 |
| Rao, AR | 3 |
| Narsaiah, B | 2 |
| Reddy, NC | 1 |
| Sridhar, V | 1 |
| Rao, JV | 1 |
| Karegoudar, P | 1 |
| Prasad, DJ | 1 |
| Ashok, M | 1 |
| Mahalinga, M | 1 |
| Poojary, B | 1 |
| Holla, BS | 1 |
| Burguete, A | 1 |
| Villar, R | 1 |
| Vicente, E | 1 |
| Solano, B | 1 |
| Ancizu, S | 1 |
| Pérez-Silanes, S | 1 |
| Aldana, I | 1 |
| Monge, A | 1 |
| Sharma, M | 1 |
| Ray, SM | 1 |
| Szabó, G | 1 |
| Fischer, J | 2 |
| Kis-Varga, A | 1 |
| Gyires, K | 2 |
| Picerno, P | 1 |
| Mencherini, T | 1 |
| Rastrelli, L | 1 |
| Piccinelli, A | 1 |
| Aquino, R | 1 |
| Velázquez, CA | 3 |
| Chen, QH | 1 |
| Citro, ML | 1 |
| Keefer, LK | 1 |
| Knaus, EE | 3 |
| Barlow, JW | 1 |
| Walsh, JJ | 1 |
| Abouzid, K | 1 |
| Bekhit, SA | 1 |
| Abdel-Megeed, AM | 1 |
| Abdel-Rahman, HM | 2 |
| Alkaramany, GE | 1 |
| El-Gendy, MA | 1 |
| Shoman, ME | 2 |
| Abdel-Aziz, M | 5 |
| Aly, OM | 2 |
| Farag, HH | 2 |
| Morsy, MA | 1 |
| Su, CR | 1 |
| Chen, YF | 1 |
| Liou, MJ | 1 |
| Tsai, HY | 1 |
| Chang, WS | 1 |
| Wu, TS | 2 |
| el-Gazzar, AB | 1 |
| Hafez, HN | 1 |
| Nawwar, GA | 1 |
| Barsoum, FF | 1 |
| Symeonidis, T | 2 |
| Chamilos, M | 1 |
| Kallitsakis, M | 1 |
| Litinas, KE | 3 |
| Khanum, SA | 1 |
| Girish, V | 1 |
| Suparshwa, SS | 1 |
| Khanum, NF | 1 |
| Chikhale, RV | 1 |
| Bhole, RP | 1 |
| Khedekar, PB | 2 |
| Bhusari, KP | 2 |
| Paulino, N | 2 |
| Rodrigues, NC | 1 |
| Pardi, PC | 1 |
| Suárez, JA | 1 |
| dos Santos, RP | 1 |
| Scremin, A | 2 |
| Vogel, C | 1 |
| Feist, H | 1 |
| Michalik, D | 1 |
| Vasilevsky, SF | 1 |
| Govdi, AI | 1 |
| Shults, EE | 1 |
| Shakirov, MM | 1 |
| Sorokina, IV | 1 |
| Tolstikova, TG | 1 |
| Baev, DS | 1 |
| Tolstikov, GA | 1 |
| Alabugin, IV | 1 |
| Gökçe, M | 2 |
| Utku, S | 1 |
| Amin, KM | 2 |
| Hanna, MM | 2 |
| Abo-Youssef, HE | 1 |
| George, RF | 2 |
| Aytaç, SP | 1 |
| Tozkoparan, B | 3 |
| Kaynak, FB | 1 |
| Unüvar, S | 1 |
| Bhandari, SV | 1 |
| Dangre, SC | 1 |
| Bothara, KG | 1 |
| Patil, AA | 1 |
| Sarkate, AP | 1 |
| Lokwani, DK | 1 |
| Gore, ST | 1 |
| Deshmane, BJ | 1 |
| Raparti, VT | 1 |
| Khachane, CV | 1 |
| Laddha, SS | 1 |
| Bhatnagar, SP | 1 |
| Fylaktakidou, KC | 2 |
| Koeberle, A | 1 |
| Haberl, EM | 1 |
| Pergola, C | 1 |
| Dehm, F | 1 |
| Northoff, H | 1 |
| Troschuetz, R | 1 |
| Werz, O | 2 |
| Ballabeni, V | 3 |
| Tognolini, M | 2 |
| Bertoni, S | 2 |
| Barocelli, E | 3 |
| Magoulas, GE | 3 |
| Krokidis, M | 1 |
| Papaioannou, D | 4 |
| Kamel, MM | 1 |
| Anwar, MM | 1 |
| Khedr, M | 1 |
| Syam, YM | 1 |
| Youssef, AM | 1 |
| White, MS | 1 |
| Villanueva, EB | 1 |
| El-Ashmawy, IM | 2 |
| Klegeris, A | 1 |
| El Shehry, MF | 1 |
| Abu-Hashem, AA | 1 |
| El-Telbani, EM | 1 |
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| Jahn, U | 2 |
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| Griffin, CL | 1 |
| Misher, A | 1 |
| O-Ishi, S | 1 |
| Sakuma, A | 1 |
| Miyashita, F | 1 |
| Nishitani, R | 1 |
| Grant, TJ | 1 |
| Jaques, LW | 1 |
| Artini, D | 1 |
| Melloni, P | 1 |
| Vita, G | 1 |
| Kadokawa, T | 1 |
| Nakatsuji, K | 1 |
| Nakamura, K | 1 |
| Green, AY | 1 |
| Murray, PA | 1 |
| Limet, R | 1 |
| Lecomte, J | 1 |
| Silber, RH | 1 |
| Barron, DI | 1 |
| Copley, AR | 1 |
| Vallance, DK | 1 |
| Dittmar, FK | 1 |
| el-Salamouny, AR | 1 |
| Benvenuti, F | 1 |
| Lattanzi, F | 1 |
| De Gori, A | 1 |
| Tarli, P | 1 |
| Shanahan, RW | 1 |
| Piliero, SJ | 1 |
| Colombo, C | 1 |
| Schreiber, W | 1 |
| Hugo, R | 1 |
| Jakovlev, V | 1 |
| von Schlichtegroll, A | 1 |
| Adrian, RW | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Three-way Cross-over Comparative Pharmacokinetic Study of Resveratrol Comprising Products in Fasting Healthy Subjects[NCT01747252] | 15 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| [NCT01943136] | Phase 1 | 128 participants (Anticipated) | Interventional | 2013-08-31 | Recruiting | ||
| Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty: A Pilot Randomized Control Trial[NCT02406131] | 40 participants (Anticipated) | Interventional | 2018-04-30 | Suspended (stopped due to logistic issues - no available scans for participants at the moment need to postponed starting dates) | |||
| A Multicenter, Randomized, Open-label, Controlled Trial to Assess Effectiveness and Safety of Rhea Health Tone® as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia[NCT04627519] | 85 participants (Actual) | Interventional | 2020-12-09 | Active, not recruiting | |||
| Cytokine Responses to Acute Inflammation in the Oral Surgery Model[NCT00006175] | 160 participants | Observational | 2000-08-31 | Completed | |||
| A Randomized, Masked Comparison of Topical Ketorolac 0,4% Versus Placebo in Cataract Surgery.[NCT01542190] | Phase 4 | 80 participants (Anticipated) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for indomethacin and Edema
| Article | Year |
|---|---|
The emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Conjunctivitis, | 1996 |
[Treatment of ankylosing spondylitis].
Topics: Agranulocytosis; Anti-Inflammatory Agents; Balneology; Edema; Exercise Therapy; Humans; Indomethacin | 1979 |
Burn shock.
Topics: Animals; Blood Circulation; Burns; Capillary Permeability; Catecholamines; Dextrans; Dogs; Edema; He | 1974 |
Drug reactions. XII. Cutaneous reactions to anti-rheumatic drugs.
Topics: Adult; Anti-Inflammatory Agents; Drug Eruptions; Edema; Female; Gold; Humans; Indomethacin; Lymphade | 1970 |
Pharmacological properties of naproxen.
Topics: Administration, Oral; Administration, Topical; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory A | 1973 |
17 trials available for indomethacin and Edema
| Article | Year |
|---|---|
Solid lipid nanoparticles of guggul lipid as drug carrier for transdermal drug delivery.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Commiphora; Drug Carriers; Drug Delive | 2013 |
A novel red grape cells complex: health effects and bioavailability of natural resveratrol.
Topics: Adult; Animals; Biological Availability; Carrageenan; Cross-Over Studies; Edema; Humans; Indomethaci | 2014 |
Incidence of cystoid macular edema after retinal detachment surgery and the use of topical indomethacin.
Topics: Administration, Topical; Clinical Trials as Topic; Double-Blind Method; Edema; Female; Humans; Indom | 1983 |
A multicentre comparison of piroxicam and indomethacin in acute soft tissue sports injuries.
Topics: Athletic Injuries; Clinical Trials as Topic; Edema; Female; Humans; Indomethacin; Joints; Male; Pain | 1984 |
Prophylaxis of pseudophakic cystoid macular edema with topical indomethacin.
Topics: Adrenal Cortex Hormones; Adult; Aged; Cataract Extraction; Clinical Trials as Topic; Double-Blind Me | 1982 |
Incidence of aphakic cystoid macular edema with the use of topical indomethacin.
Topics: Cataract Extraction; Clinical Trials as Topic; Double-Blind Method; Edema; Eye Diseases; Humans; Ind | 1981 |
[Clinical trials with acemetacin on children and adolescents (author's transl)].
Topics: Adolescent; Anti-Inflammatory Agents; Body Temperature; Child; Child, Preschool; Double-Blind Method | 1980 |
Slit-lamp fluorophotometry in intraocular lens patients.
Topics: Aqueous Humor; Biological Transport; Blood; Capillary Permeability; Edema; Fluoresceins; Fluorometry | 1980 |
Long-term follow-up study on prevention of aphakic cystoid macular oedema by topical indomethacin.
Topics: Administration, Topical; Aged; Aphakia, Postcataract; Double-Blind Method; Edema; Female; Follow-Up | 1980 |
The effects of topical indomethacin and clobetasol propionate on post-cryotherapy inflammation.
Topics: Administration, Topical; Adolescent; Adult; Child; Clobetasol; Cryotherapy; Dermatitis; Double-Blind | 1995 |
Ineffectiveness of indomethacin in the treatment of chronic cystoid macular edema.
Topics: Aged; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Edema; Female; Humans; Indomet | 1977 |
[Double-blind study on the anti-inflammatory effect of indomethacin after surgical removal of lower wisdom teeth].
Topics: Adult; Body Temperature; Clinical Trials as Topic; Double-Blind Method; Edema; Female; Humans; Indom | 1979 |
Indomethacin as a means of preventing cystoid macular edema following intracapsular cataract extraction.
Topics: Aged; Cataract Extraction; Edema; Evaluation Studies as Topic; Humans; Indomethacin; Macula Lutea; M | 1979 |
Analgesic and antiinflammatory effects of glucamethacin (a nonsteroidal antiinflammatory analgesic) after the removal of impacted third molars.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chi-Square Distribution; Double | 1990 |
Pain relief with indomethacin in external otitis.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Edema; Female; Humans; Indomethacin; Inflammation | 1972 |
Ketoprofen: a preliminary report of its pharmacological activity and therapeutic efficacy in rheumatic disorders.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antipyrine; Arthritis, Rheumatoid; Benzophenones; Bra | 1974 |
[Our experiences with indocin in the treatment of postoperative pain and postoperative edema].
Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Drug Evaluation; Edema; Female; Humans; In | 1974 |
846 other studies available for indomethacin and Edema
| Article | Year |
|---|---|
2-(Substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines as nonacidic antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1978 |
Synthesis and antiinflammatory activity of cis-4,5,6,7,8,8a,9-hexahydro-alpha-methyl-5H-fluorene-2-acetic acid.
Topics: Animals; Anti-Inflammatory Agents; Arthus Reaction; Edema; Fluorenes; Magnetic Resonance Spectroscop | 1977 |
Synthesis and antiinflammatory activity of 6,11-dihydro-11-oxodibenzo[b,e]thiepinalkanoic acids and related compounds.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Exp | 1978 |
Syntheses and antiinflammatory actions of 4,5,6,7-tetrahydroindazole-5-carboxylic acids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Edema; Indazole | 1979 |
Potential antiarthritic agents. 2. Benzoylacetonitriles and beta-aminocinnamonitriles.
Topics: Acetonitriles; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Edema; Erythema; Guinea P | 1979 |
Potential antiinflammatory compounds. 3. Compounds derived from acenaphthene and indan.
Topics: Acenaphthenes; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Edema; Indan | 1979 |
Nonsteroidal antiinflammatory agents. 2. Derivatives/analogues of dibenz[b,e]oxepin-3-acetic acid.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dibenzoxepins; Edema; Lethal Dose 50; Male; Rats; St | 1978 |
Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 1. 6,11-Dihydro-11-oxodibenz]b,e]oxepin-2-acetic acids.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Dibenzoxepins; Drug Evaluation, Preclinical; Edema; Mi | 1977 |
Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 2. Dihydro-10-oxofuro-and -thieno[3,2-c][1]benzoxepin-8-acetic acids.
Topics: Animals; Anti-Inflammatory Agents; Benzoxepins; Edema; Gastric Mucosa; Methods; Rats; Structure-Acti | 1977 |
Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. omega-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)alkanoic acids.
Topics: Animals; Anti-Inflammatory Agents; Carboxylic Acids; Dibenzoxepins; Edema; Rats; Structure-Activity | 1977 |
6,11-Dihydro-11-oxodibenz [b,e] oxepinacetic acids with potent antiinflammatory activity.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dibenzoxepins; Edema; Female; Le | 1976 |
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes; | 1976 |
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Calcimycin; Cyclooxyge | 1992 |
A novel synthesis and potent antiinflammatory activity of 4-hydroxy-2(1H)-oxo-1-phenyl-1,8-naphthyridine-3-carboxamides.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Male | 1992 |
Synthesis of 3-(2-pyridylethyl)benzoxazolinone derivatives: potent analgesic and antiinflammatory compounds inhibiting prostaglandin E2.
Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 1992 |
Bis basic substituted diaminobenzobisthiazoles as potential antiarthritic agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Hemolytic Plaque T | 1992 |
2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Chemical Phenomena; Chemis | 1990 |
1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Arachidonic Acid; Arac | 1990 |
Antiinflammatory 2,6-di-tert-butyl-4-(2-arylethenyl)phenols.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Phenomena; Chemi | 1989 |
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-ca rboxyl ic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids.
Topics: Acetates; Analgesia; Animals; Aspirin; Benzoquinones; Carboxylic Acids; Carrageenan; Chemical Phenom | 1989 |
Benzimidazole derivatives with atypical antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Benzimidazoles | 1987 |
Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indo le-1-a cetic acid, a potent analgesic agent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; In Vitro Techniques; Indoleacetic Acids; Ma | 1988 |
Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzoxepins; Edema; Gastrointestinal Hemorrhage; Male | 1986 |
Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Chemical Phenomena; Che | 1982 |
Bulky amine analogues of ketoprofen: potent antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Chemical Phenomena; Chemistry; Drug Eval | 1984 |
Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 4. Synthesis and evaluation of 4-(4,10-dihydro-10-oxothieno[3,2-c] [1]benzoxepin-8-yl)butanol and -butyric acid and related derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Benzoxepins; Butyrates; Edema; Male | 1984 |
Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Indans; Indenes; M | 1984 |
3-Alkyl-2-aryl-3H-naphth[1,2-d]imidazoles, a novel class of nonacidic antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Evaluation, Preclini | 1984 |
Basic antiinflammatory compounds. N,N',N''-Trisubstituted guanidines.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cattle; Edema; Female; Guanidines; In Vi | 1980 |
Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, E | 1982 |
Antiinflammatory properties of 8-aryl-5-isopropyl-2H-1,3-dioxolo[4,5-g]quinazolin-6(5H)-ones and -thiones.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Bradykinin; Carrageenan; Chemical Phenom | 1982 |
2,3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzofurans; Cattle; Chemical Phenomena; | 1981 |
Glycerides as prodrugs. 3. Synthesis and antiinflammatory activity of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetyl]glycerides (indomethacin glycerides).
Topics: Animals; Arthritis, Experimental; Edema; Glycerides; Indomethacin; Male; Rats; Stomach Ulcer; Struct | 1980 |
1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyc | 1995 |
3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cell Line; Chalcone; C | 1993 |
Isolation of two flavonoids from Tanacetum microphyllum as PMA-induced ear edema inhibitors.
Topics: Animals; Ear; Edema; Female; Flavonoids; Mice; Plants; Spectrophotometry, Ultraviolet; Tetradecanoyl | 1997 |
1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1997 |
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bee Venoms; Carrageenan; Cell Lin | 1998 |
Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal; | 1998 |
2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetinae; Cyclo | 1998 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cycl | 1999 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan | 1999 |
Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols.
Topics: Amino Alcohols; Animals; Anti-Inflammatory Agents; Cell Survival; Edema; Inhibitory Concentration 50 | 1999 |
A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 1999 |
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line | 2000 |
Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Blood Platelet | 2000 |
Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyc | 2000 |
2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.
Topics: Animals; Arthritis, Experimental; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygena | 2001 |
Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxy | 2001 |
Antiinflammatory constituents from Heterotheca inuloides.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Disease Models, Animal; Dose-Response | 2001 |
Design, synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: a new class of anti-inflammatory and anti-platelet agents.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical | 2002 |
Synthesis and In vivo anti-inflammatory activity of long-chain 2-amino-alcohols.
Topics: Amino Alcohols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Indica | 2003 |
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclic AMP-Dependent Protein Kina | 2003 |
Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus.
Topics: Animals; Anti-Inflammatory Agents; Ear; Edema; Lanosterol; Methylation; Mice; Molecular Structure; N | 2003 |
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonamides; Binding Sites; Cyclooxygenase | 2003 |
Griffonianone D, an isoflavone with anti-inflammatory activity from the root bark of Millettia griffoniana.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cameroon; Ear; Edema; Flavonoids; | 2003 |
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azo Compounds; Carrageenan; Coumarin | 2004 |
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives.
Topics: Adult; Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge | 2004 |
Synthesis and antiinflammatory activity of coumarin derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Coumarins; C | 2005 |
Nitrogen-containing phorbol esters from Croton ciliatoglandulifer and their effects on cyclooxygenases-1 and -2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Croton; Cyclooxygenase 1; Cyclooxygenase 2; Cycloo | 2006 |
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.
Topics: Analgesics; Anilides; Animals; Benzenesulfonates; Carrageenan; Colorimetry; Crystallography, X-Ray; | 2007 |
Antinociceptive and antiinflammatory activities and QSAR studies on 2-substituted-4,5-diphenyl-1H-imidazoles.
Topics: Algorithms; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cluste | 2007 |
Synthesis of 2-methyl-3-indolylacetic derivatives as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 without gastric damage.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2006 |
Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antigens, Viral; Antineoplastic Agents, | 2006 |
Novel synthesis of [1]-benzothiepino[5,4-b]pyridine-3-carbonitriles and their anti-inflammatory properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiepins; Carrageenan; Edema; Female; Male; M | 2007 |
Evaluation of the anti-inflammatory and anti-nociceptive activities of novel synthesized melatonin analogues.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Edema; Extremities; Melatonin; Mice; Mo | 2007 |
Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biphenyl Compounds; Carragee | 2007 |
Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (Noni).
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antigens, Viral; Caproat | 2007 |
Triterpene glycosides from the flower petals of sunflower (Helianthus annuus) and their anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Ear; Edema; Flowers; Glycosides; Helianthus; Mice; Molecular Stru | 2007 |
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cyclooxygenase 1; C | 2008 |
1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Benzoxazoles; Crystallography, | 2007 |
1,8-Naphthyridines VI. Synthesis and anti-inflammatory activity of 5-(alkylamino)-N,N-diethyl[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides with a new substitution pattern on the triazole ring.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Drug Design; Edema; Inflammation; Male; Naphthyridin | 2008 |
Synthesis and pharmacochemical evaluation of novel aryl-acetic acid inhibitors of lipoxygenase, antioxidants, and anti-inflammatory agents.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Edema; Free Radicals; Hin | 2007 |
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.
Topics: Alzheimer Disease; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Hindlimb; Hydrogen Bonding; | 2007 |
Synthesis of novel 4,6-disubstituted quinazoline derivatives, their anti-inflammatory and anti-cancer activity (cytotoxic) against U937 leukemia cell lines.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cell Proliferation; Edema; Hu | 2008 |
Synthesis, antimicrobial and anti-inflammatory activities of some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing trichlorophenyl moiety.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Edema; Fungi; Magne | 2008 |
Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Edema; Pyrazoles; Quinoxalines; Rats | 2007 |
Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid as anti-inflammatory agents free of ulcerogenic liability.
Topics: Acetates; Amides; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Carrageenan; Cytochrome | 2007 |
New celecoxib derivatives as anti-inflammatory agents.
Topics: Acetic Acid; Animals; Carrageenan; Celecoxib; Chronic Disease; Crystallization; Cyclooxygenase 1; Cy | 2008 |
Isoprenoid glycosides from Liriosma ovata.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Croton Oil; Ear, External; Edema; Glucosides; Inhi | 2008 |
Facile synthesis of dithiatetraaza-macrocycles of potential anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aza Compounds; Carrageenan; Drug Discovery; Edema; | 2008 |
Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azo Compounds; Carr | 2008 |
Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds.
Topics: Amides; Amines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Disease Models, | 2008 |
Novel anti-inflammatory agents based on pyridazinone scaffold; design, synthesis and in vivo activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Carrageenan; Cyclooxygenase 2; Cycl | 2008 |
Regioselective synthesis of dispiro[1H-indene-2,3'-pyrrolidine-2',3''-[3H]indole]-1,2''(1''H)-diones of potential anti-tumor properties.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, A | 2009 |
Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity.
Topics: Acetates; Acylation; Animals; Anti-Inflammatory Agents; Drug Design; Drug-Related Side Effects and A | 2009 |
Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives.
Topics: Animals; Anti-Inflammatory Agents; Edema; Indomethacin; Male; Nitric Oxide; Pyrazoles; Rats; Referen | 2009 |
Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Diterpenes; Edema; Macrophages; Menispermaceae; | 2008 |
New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines.
Topics: Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antioxidants; Bacteria; Carrag | 2009 |
Facile synthesis of bis(4,5-dihydro-1H-pyrazole-1-carboxamides) and their thio-analogues of potential PGE(2) inhibitory properties.
Topics: Amides; Animals; Anti-Inflammatory Agents; Dinoprostone; Drug Evaluation, Preclinical; Edema; Pyrazo | 2009 |
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
Topics: Animals; Antioxidants; Biphenyl Compounds; Combinatorial Chemistry Techniques; Coumarins; Edema; Lip | 2009 |
Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Coumarins; Edema; Female; Glycine max; Lipoxygenase | 2009 |
Benzophenone-N-ethyl piperidine ether analogues--synthesis and efficacy as anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Benzophenones; Carrageenan; Edema; Mice; Piperidines; Prostagland | 2009 |
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper | 2009 |
Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
Topics: Analgesics; Animals; Anisoles; Anti-Inflammatory Agents; Cell Line; Cell Survival; Dinoprostone; Ede | 2009 |
Efficient synthesis of the first betulonic acid-acetylene hybrids and their hepatoprotective and anti-inflammatory activity.
Topics: Acetylene; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Edema; Enzymes | 2009 |
Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal)hydrazone derivatives.
Topics: Abdominal Pain; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Hydrazones; Inf | 2009 |
Synthesis, analgesic and anti-inflammatory activities evaluation of some bi-, tri- and tetracyclic condensed pyrimidines.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Crystallography, X-Ray; Edema; Mice; Models, Molecula | 2009 |
Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Edema; Female; Male; Mice; | 2009 |
Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Edema; Female; Male; Mice; Model | 2009 |
A new therapeutic approach in Parkinson's disease: some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Child, Preschool; Cyclic Nucleotide Phosphodiesterases, Type 1; D | 2009 |
Synthesis and anti-inflammatory evaluation of novel angularly or linearly fused coumarins.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Coumarins; Edema; Female; Male; Molecular Structure | 2009 |
Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
Topics: Animals; Anti-Inflammatory Agents; Carboxylic Acids; Cell Line, Tumor; Edema; Enzyme Inhibitors; Hum | 2009 |
1,8-Naphthyridines VIII. Novel 5-aminoimidazo[1,2-a] [1,8]naphthyridine-6-carboxamide and 5-amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamide derivatives showing potent analgesic or anti-inflammatory activity, respectively, and completely devoi
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Female; Male; Mice; Motor Activity; Naphthyrid | 2010 |
Syntheses and evaluation of the antioxidant activity of acitretin analogs with amide bond(s) in the polyene spacer.
Topics: Acitretin; Amides; Animals; Antioxidants; Edema; Electrons; Esters; Female; Glycine max; Heterocycli | 2010 |
Synthesis, biological evaluation and molecular docking of novel series of spiro [(2H,3H) quinazoline-2,1'- cyclohexan]-4(1H)- one derivatives as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclohexanes; Cyclohexanones; Cyclooxygenase 2; Edema | 2010 |
Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Edema; Gran | 2010 |
Synthesis of 3-((2,4-dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines) as anti-inflammatory and molluscicidal agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomphalaria; Carrageenan; Drug Evaluation, Precli | 2010 |
Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzimidazoles; Carrageenan; Edema; Male; Mice; Rats; | 2010 |
Labdanes and sucrose esters from Physalis sordida.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Crystallography, X-Ray; Diterpenes; Edema; Esters; | 2010 |
3-Formylchromones: potential antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromones; Cyclooxygenase Inhibitors; | 2010 |
Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Ear; Edema; Female; Freund's Adjuvant; Hyd | 2010 |
Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Cyclooxygenase 2; Cyclooxygenase 2 I | 2010 |
Use of phosphonyl carbanions in the synthesis of anti-inflammatory active phosphorus-containing fused heterocycles and relevance phosphonates.
Topics: Animals; Anions; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, Drug; Edema; Fem | 2010 |
Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Edema; Female | 2010 |
Lupane triterpenes with a δ-lactone at ring E, from Lippia mexicana.
Topics: Animals; Anti-Inflammatory Agents; Crystallography, X-Ray; Disease Models, Animal; Edema; Lactones; | 2010 |
Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents.
Topics: Animals; Anti-Bacterial Agents; Candida albicans; Carrageenan; Catalytic Domain; Cotton Fiber; Cyclo | 2010 |
Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?
Topics: Acitretin; Animals; Anti-Inflammatory Agents; Antioxidants; Edema; Levodopa; Lipid Peroxidation; Rat | 2010 |
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Edema; Est | 2011 |
Synthesis and biological evaluation of orally active prodrugs of indomethacin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Stability; | 2011 |
Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzylidene Compounds; Carrageenan; Cell | 2011 |
Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin.
Topics: Analgesics; Animals; Brazil; Dinoprostone; Edema; Freund's Adjuvant; Mice; Models, Animal; Molecular | 2011 |
Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Catalytic Domain; Computer Simulation; Edema; Imid | 2011 |
Vicenin-2, a potential anti-inflammatory constituent of Urtica circularis.
Topics: Animals; Anti-Inflammatory Agents; Apigenin; Edema; Glucosides; Lipopolysaccharides; Macrophages; Mi | 2011 |
Analogue-based design, synthesis and molecular docking analysis of 2,3-diaryl quinazolinones as non-ulcerogenic anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase I | 2011 |
Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms.
Topics: Acetic Acid; Analgesics; Anemia, Sickle Cell; Animals; Anti-Inflammatory Agents; Antisickling Agents | 2011 |
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Austria; Benzofurans; | 2011 |
Fuscoside E: a strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca.
Topics: Animals; Anthozoa; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacillus; Biologi | 2011 |
Antinociceptive properties of bergenin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Dose-Response Relationshi | 2011 |
Discovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: the nitroindazolinone chemotype.
Topics: Animals; Anti-Inflammatory Agents; Cell Movement; Discriminant Analysis; Drug Design; Drug Discovery | 2011 |
Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygen | 2012 |
Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blood-Brain Barrier; Cell Hypoxia; C | 2012 |
Synthesis, anti-inflammatory activity and ulcerogenic liability of novel nitric oxide donating/chalcone hybrids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chalcone; Edema; Gastrointestinal Tra | 2012 |
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Cyclooxygenase 1; Cyclooxy | 2012 |
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Dose-Response Relationshi | 2012 |
A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Blotting, Western; Cell Line; Cyclooxygenase | 2012 |
Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Diterpenes; Edema; Lipopolysacchar | 2012 |
Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzothiazoles; Click Chemistry; Cyclooxygenase Inhib | 2012 |
Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Edema; Models, Mole | 2012 |
Computer-assisted rational design, synthesis, and bioassay of non-steroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Computer-Aided Design; Drug Design; E | 2012 |
Neo-clerodane diterpenes from Salvia herbacea.
Topics: Animals; Crystallography, X-Ray; Diterpenes, Clerodane; Drug Screening Assays, Antitumor; Edema; Ind | 2012 |
Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzopyrans; Carrageenan; Catalytic Doma | 2012 |
Eunicidiol, an anti-inflammatory dilophol diterpene from Eunicea fusca.
Topics: Animals; Anthozoa; Anti-Inflammatory Agents, Non-Steroidal; Diterpenes; Edema; Indomethacin; Mice; M | 2012 |
New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cy | 2012 |
Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Drug Design; Edema; Formaldehyde | 2012 |
Design, synthesis, antimicrobial, anti-inflammatory and analgesic activity of novel isoxazolyl pyrimido[4,5-b]quinolines and isoxazolyl chromeno[2,3-d]pyrimidin-4-ones.
Topics: Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Behavior, Animal; Ch | 2012 |
Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biphenyl Compounds; Cyclooxygenase 1 | 2012 |
Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Bacterial Infections; Carrageena | 2012 |
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug | 2012 |
Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agen | 2012 |
Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cycloo | 2013 |
Microfluidics assisted synthesis and bioevaluation of sinomenine derivatives as antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Survival; Dose-Response Relation | 2013 |
Synthesis and pharmacological evaluation of some novel 2-(5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)thiazoles.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Coumarins; Dose-Response Re | 2013 |
Novel quinolone substituted thiazolidin-4-ones as anti-inflammatory, anticancer agents: design, synthesis and biological screening.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Ehrlich Tumor; Carra | 2013 |
Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzoquinones; Carrageenan; Cyclooxygenase 1; Cycloox | 2013 |
Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives.
Topics: Alzheimer Disease; Animals; Antioxidants; Biocatalysis; Biphenyl Compounds; Carrageenan; Edema; Fema | 2013 |
New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Edema; Hu | 2013 |
Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Chalcones; Cyclooxygenase | 2013 |
Synthesis and biological evaluation of some novel thiazole compounds as potential anti-inflammatory agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacillus cereus; Carrageena | 2013 |
Design, synthesis and biological evaluation of novel anti-cytokine 1,2,4-triazine derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Carrageenan; Cell Survival; Cells, | 2013 |
Synthesis, biological evaluation and molecular modeling study of 5-trifluoromethyl-Δ²-pyrazoline and isomeric 5/3-trifluoromethylpyrazole derivatives as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2013 |
Synthesis of novel 1,2,3-triazole based benzoxazolinones: their TNF-α based molecular docking with in-vivo anti-inflammatory, antinociceptive activities and ulcerogenic risk evaluation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Carrageenan; Cyclooxygenase 2; Cyclo | 2013 |
1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Edem | 2014 |
Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2014 |
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; | 2014 |
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.
Topics: Animals; Anisoles; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxyg | 2014 |
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
Topics: Animals; Anti-Inflammatory Agents; Chrysanthemum; Cyclooxygenase 2; Cytokines; Dinoprostone; Down-Re | 2014 |
Conventional and microwave assisted synthesis of pyrazolone Mannich bases possessing anti-inflammatory, analgesic, ulcerogenic effect and antimicrobial properties.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2014 |
Sesquiterpenoids from Pittocaulon filare.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Disease Models, Animal; Edema; Glucosides; Indomethac | 2014 |
Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Car | 2014 |
Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Edema; HeLa Cells; Histone Deacetylase Inhibitors; | 2014 |
1,8-Naphthyridines IX. Potent anti-inflammatory and/or analgesic activity of a new group of substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides, of some their Mannich base derivatives and of one novel substituted 5-amino-10-oxo-10H-
Topics: Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cells, Cultured; | 2014 |
Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Coumarins; Cyclooxygenase 2; Cyclooxy | 2014 |
Synthesis and evaluation of anti-inflammatory activity of derivatives of the marine natural products fuscol and eunicol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Diterpenes; Dose-Response Rel | 2014 |
Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Analgesics; Anti-Inflammatory Agents; Carrageenan; Cyclic GMP; Diterpenes; Edema; Freun | 2014 |
Antinociceptive properties of physalins from Physalis angulata.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Freund's Adjuvant; Hyp | 2014 |
Benzimidazole--ibuprofen/mesalamine conjugates: potential candidates for multifactorial diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Benzimidazoles; Edema; Ibup | 2015 |
Synthesis, analgesic, anti-inflammatory and anti-ulcerogenic activities of certain novel Schiff's bases as fenamate isosteres.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Edema; Fenamates; Male; Mice; Rats | 2015 |
Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases.
Topics: Animals; Benzylidene Compounds; Carrageenan; Cell Line; Dose-Response Relationship, Drug; Edema; Enz | 2015 |
Absolute configuration of labdane diterpenoids from Physalis nicandroides.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Crystallography, X-Ray; Disease Models, Animal; Di | 2015 |
Synthesis and biological evaluation of pyrazolylthiazole carboxylic acids as potent anti-inflammatory-antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Carboxylic Acids; Edema; Fungi; Gram-Posit | 2015 |
Rapid 'one-pot' synthesis of a novel benzimidazole-5-carboxylate and its hydrazone derivatives as potential anti-inflammatory and antimicrobial agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Aspergillus niger; Benzimidazol | 2015 |
Synthesis, antinociceptive and anti-inflammatory effects of porphyrins.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Exper | 2015 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; D | 2015 |
Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Benzoxazoles; Carragee | 2015 |
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cycloox | 2015 |
Molecular docking design and one-pot expeditious synthesis of novel 2,5-diarylpyrazolo[1,5-a]pyrimidin-7-amines as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2015 |
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine ma | 2015 |
Synthesis and biological evaluation of new C-10 substituted dithranol pleiotropic hybrids.
Topics: Amides; Animals; Anthralin; Anti-Inflammatory Agents; Antioxidants; Binding Sites; Carrageenan; Cell | 2015 |
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 I | 2015 |
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hype | 2016 |
Synthesis and anti-inflammatory activity evaluation of a novel series of 6-phenoxy-[1,2,4]triazolo[3,4-a]phthalazine-3-carboxamide derivatives.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Dose-Response | 2016 |
Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Cytokines; Disease Models, Animal | 2016 |
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2016 |
Terpenoids from Melampodium perfoliatum.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Dose-Response Relationship, Drug; Edema; Indomethacin | 2016 |
In vivo and in silico anti-inflammatory mechanism of action of the semisynthetic (-)-cubebin derivatives (-)-hinokinin and (-)-O-benzylcubebin.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Catalytic Domain; | 2017 |
Synthesis, molecular docking and biological evaluation of some newer 2-substituted-4-(benzo[d][1,3]dioxol-5-yl)-6-phenylpyridazin-3(2H)-ones as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan; Cyclooxy | 2017 |
Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Benzimidazoles; C | 2017 |
Synthesis, potential anti-inflammatory and analgesic activities study of (S)-N-substituted-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamides.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cy | 2017 |
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Ede | 2017 |
Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema.
Topics: Animals; Bradykinin; Bridged Bicyclo Compounds; Diabetes Complications; Diabetic Retinopathy; Edema; | 2018 |
Functionalized spirooxindole-indolizine hybrids: Stereoselective green synthesis and evaluation of anti-inflammatory effect involving TNF-α and nitrite inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Crystallography, X-Ray; Disease Model | 2018 |
Synthesis of proline derived benzenesulfonamides: A potent anti-Trypanosoma brucei gambiense agent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiprotozoal Agents; Benzenesulfonamides; Carrage | 2018 |
Synthesis and biological properties of aryl methyl sulfones.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimet | 2018 |
Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives.
Topics: Acylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase | 2018 |
Synthesis and biological evaluation of pyridazinone derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2019 |
Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carrageenan; Cyclooxygen | 2019 |
Synthesis and highly potent anti-inflammatory activity of licofelone- and ketorolac-based 1-arylpyrrolizin-3-ones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Dose-Response Relationsh | 2019 |
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan | 2020 |
Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 15-Lipoxygenase; Benzimidazoles; Carrageenan; Cycloo | 2020 |
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2020 |
Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Catalytic Domain; Cell Line; Cell Survival; Cycloo | 2020 |
Synthesis and evaluations of selective COX-2 inhibitory effects: Benzo[d]thiazol analogs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 | 2020 |
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2021 |
Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; | 2021 |
Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies.
Topics: Alanine; Animals; Biological Availability; Biological Products; Carrageenan; Chemical Engineering; C | 2021 |
Water Mediated One-Pot, Stepwise Green Synthesis, Anti-Inflammatory and Analgesic Activities of (3-Amino-1-Phenyl-1H-Benzo[f]Chromen-2-yl) (1H-Indol-3-yl) Methanone Catalysed by L-Proline.
Topics: Analgesics; Animals; Anthocyanins; Anti-Inflammatory Agents; Benzopyrans; Carrageenan; Catalysis; Di | 2022 |
Microemulsions and nanoemulsions modified with cationic surfactants for improving the solubility and therapeutic efficacy of loaded drug indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Drug Carriers; Edema; Emulsions; Humans | 2022 |
Evaluation of Antiarthritic and Antinociceptive Effects of Cedrol in a Rat Model of Arthritis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Edema; Freund' | 2022 |
Exploration of molecular mechanisms responsible for anti-inflammatory and anti-angiogenic attributes of methanolic extract of Viola betonicifolia.
Topics: Animals; Anti-Inflammatory Agents; Edema; Indomethacin; Inflammation; Methanol; Plant Extracts; Viol | 2022 |
Ficus vogelii methanol leaf extract ameliorates inflammation and arthritis by modulating osmotic fragility in C57BL/6J mice.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Diclofenac; Edema; Ficus; G | 2021 |
Synthesis, Molecular Docking and ADME Prediction of 1H-indole/5- substituted Indole Derivatives as Potential Antioxidant and Anti- Inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cyclooxygenase 2; Edema; Indomethacin; | 2023 |
Nonacidic thiophene-based derivatives as potential analgesic and design, synthesis, biological evaluation, and metabolic stability study.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; C | 2022 |
Beneficial interaction of pycnogenol with indomethacin in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Edema; Flavonoids; Glutathione; In | 2022 |
Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colocasia; Cyclooxygenase 2; Cytokines; Dinoprostone | 2023 |
Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colocasia; Cyclooxygenase 2; Cytokines; Dinoprostone | 2023 |
Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colocasia; Cyclooxygenase 2; Cytokines; Dinoprostone | 2023 |
Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colocasia; Cyclooxygenase 2; Cytokines; Dinoprostone | 2023 |
New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen | 2023 |
Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics | 2023 |
Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways.
Topics: Acute Disease; Animals; Biomarkers; Carrageenan; Edema; Flavonoids; Heme Oxygenase-1; Indomethacin; | 2019 |
Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids.
Topics: Administration, Oral; Aminosalicylic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachid | 2020 |
Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Celecoxi | 2020 |
Synthesis of novel N-substitutedphenyl-6-oxo-3-phenylpyridazine derivatives as cyclooxygenase-2 inhibitors.
Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Female; | 2020 |
Investigation of in vivo anti-inflammatory and anti-angiogenic attributes of coumarin-rich ethanolic extract of Melilotus indicus.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Coumarins; Disease Models, Animal; Dose- | 2021 |
Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Disease Models, Animal; Edema | 2020 |
Manjarix attenuated pain and joint swelling in a rat model of monosodium iodoacetate-induced osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis, Experimental; Cartilage, Articular; Collag | 2020 |
In vitro and in vivo anti-inflammatory effects of an ethanol extract from the aerial parts of Eryngium carlinae F. Delaroche (Apiaceae).
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Response Re | 2021 |
Incorporation of indomethacin into a mesoporous silica nanoparticle enhances the anti-inflammatory effect Indomethacin into a mesoporous silica.
Topics: Anti-Inflammatory Agents; Edema; Humans; Indomethacin; Nanoparticles; Silicon Dioxide | 2021 |
Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Dinoprostone; Dose-Respons | 2020 |
Indomethacin loaded dextran stearate polymeric micelles improve adjuvant-induced arthritis in rats: design and in vivo evaluation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dextrans; Drug Delivery S | 2021 |
New indomethacin analogs as selective COX-2 inhibitors: Synthesis, COX-1/2 inhibitory activity, anti-inflammatory, ulcerogenicity, histopathological, and docking studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Cyclooxygenase 1; | 2021 |
Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cell Proliferation; Cycloo | 2021 |
Design, synthesis, and molecular docking of novel 3,5-disubstituted-1,3,4-oxadiazole derivatives as iNOS inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Enzyme Inhibitors; In | 2021 |
Edema and Nociception Induced by
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colubridae; Cyclooxygenase Inhibitors; Dexamethaso | 2017 |
Oxazolo[4,5-b]pyridine-Based Piperazinamides as GSK-3β Inhibitors with Potential for Attenuating Inflammation and Suppression of Pro-Inflammatory Mediators.
Topics: Amides; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Female; Glyco | 2017 |
Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Hyperalgesia; Indomethacin; Interl | 2017 |
LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrage | 2018 |
Evaluation of anti-arthritic potential of Trigonella foenum graecum L. (Fenugreek) mucilage against rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cy | 2018 |
Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhi | 2019 |
A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-κB, COX-2 and iNOS signaling.
Topics: Acridones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalytic Domain; Cyclooxygenase 2; Cyc | 2019 |
Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats.
Topics: Animals; Aspirin; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Gastric | 2019 |
Activation of a retinoic acid receptor pathway by thiazolidinediones induces production of vascular endothelial growth factor/vascular permeability factor in OP9 adipocytes.
Topics: Adipocytes; Animals; Aspirin; Capillary Permeability; Cell Differentiation; Cells, Cultured; Chroman | 2013 |
Synthesis and evaluation of anti-inflammatory and analgesic activities of new 1,2,4-triazole derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Hindlimb; Indomethacin; Injection | 2014 |
The anti-inflammatory action of Bothrops jararaca snake antithrombin on acute inflammation induced by carrageenan in mice.
Topics: Animals; Anti-Inflammatory Agents; Antithrombins; Bothrops; Carrageenan; Cell Movement; Cyclooxygena | 2013 |
Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antipyretics; Carrageenan; Dinopro | 2012 |
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Carrageenan; Dinoprostone; Disease Models, Animal; Ed | 2013 |
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.
Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Mode | 2013 |
Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, Drug; Edema; Glyburide; | 2013 |
Analgesic and anti-inflammatory effects of honey: the involvement of autonomic receptors.
Topics: Adrenergic Antagonists; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2014 |
Anti-nociceptive and anti-inflammatory activities of Wrightia arborea.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apocynaceae; Disease Models, Animal; Edema; Female; I | 2013 |
Diverse in vitro and in vivo anti-inflammatory effects of trichlorido-gold(III) complexes with N6-benzyladenine derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Auranofin; Benzyl Compounds; Cell Line, Tumor; Cel | 2014 |
Transdermal enhancement effect and mechanism of iontophoresis for non-steroidal anti-inflammatory drugs.
Topics: 1-Octanol; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Car | 2014 |
Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransf | 2014 |
Rational Design and Synthesis of Benzamides as Non-ulcerogenic Anti-inflammatory Agents.
Topics: Animals; Benzamides; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Carrageenan; Cyclooxy | 2015 |
Anti-inflammatory effect of glycosaminoglycan derived from Gryllus bimaculatus (a type of cricket, insect) on adjuvant-treated chronic arthritis rat model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; C-Reactive Protein; Cell Line, Tumor; Di | 2014 |
Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Aspirin; Asteraceae; Ban | 2014 |
Antinociceptive and anti-inflammatory activities of Bridelia retusa methanolic fruit extract in experimental animals.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Chromatography, High Pressure | 2014 |
Anti-inflammatory screening and molecular modeling of some novel coumarin derivatives.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Carrageenan; Coumarins; Crystallography, X-Ray; Cy | 2015 |
N-Acetyl Cysteine Has Both Gastro-Protective and Anti-Inflammatory Effects in Experimental Rat Models: Its Gastro-Protective Effect Is Related to Its In Vivo and In Vitro Antioxidant Properties.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Catalase; Drug Evaluat | 2016 |
Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experimental; Blo | 2017 |
Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
Topics: Animals; Animals, Newborn; Antidiarrheals; Arthritis; Capsaicin; Cytokines; Disease Models, Animal; | 2015 |
Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Cyc | 2015 |
Anti-inflammatory and anti-arthritic activity of aqueous extract of Rosa centifolia in experimental rat models.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Experimental; Carrageenan; Dose- | 2017 |
Synthesis, Biological Evaluation and QSAR Studies of Newer Isoxazole Derivatives.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Chalcones; Edema; Female; Hydroxylamine; Indom | 2015 |
New Coumarin Derivatives as Potent Selective COX-2 Inhibitors: Synthesis, Anti-Inflammatory, QSAR, and Molecular Modeling Studies.
Topics: Animals; Carrageenan; Coumarins; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Di | 2015 |
Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Cyproheptadine; Dose-Re | 2016 |
Synthesis, Structure Activity Relationship (SAR), and Biological Activities of Benzylideneacetophenones Derivatives.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Carrageenan; Chalcones; Edema; F | 2015 |
HPLC profiling, antioxidant and in vivo anti-inflammatory activity of the ethanol extract of Syzygium jambos available in Bangladesh.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Bangladesh; Benzothiazoles; Chromato | 2016 |
Tissue-selective inflammation in the oral cavity of the rat.
Topics: Animals; Carrageenan; Cheek; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Histam | 2016 |
Potentiation of indomethacin-induced anti-inflammatory response by pioglitazone in carrageenan-induced acute inflammation in rats: Role of PPARγ receptors.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synerg | 2016 |
Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cotton Fiber; | 2016 |
The influence of seasonality on the content of goyazensolide and on anti-inflammatory and anti-hyperuricemic effects of the ethanolic extract of Lychnophora passerina (Brazilian arnica).
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Brazil; Bridged-Ring Compounds; Chromatography, High | 2017 |
Synthesis, Characterization and Comparison of Local Analgesic, Anti-Inflammatory, Anti-Ulcerogenic Activity of Copper and Zinc Complexes of Indomethacin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Coordination Complexes; C | 2017 |
Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst.
Topics: Animals; Anti-Inflammatory Agents; Bacopa; Cyclooxygenase 2; Disease Models, Animal; Dose-Response R | 2008 |
Anti-inflammatory activities of ethanolic extract of Carica papaya leaves.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carica; Carrageenan; Dose-Response Relat | 2008 |
Topical anti-inflammatory and antipruritic effects of Alpinia katsumadai extracts.
Topics: Administration, Topical; Alpinia; Animals; Anti-Inflammatory Agents; Antipruritics; Disease Models, | 2009 |
Anti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animals.
Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relatio | 2008 |
The antiinflammatory, gastroprotective and antioxidant activities of Hieracium gymnocephalum extract.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Asteraceae; Dose-Response Relati | 2008 |
Inhibition of carrageenan-induced edema by tripleurospermum disciforme extract in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, Drug; Edema; Indomethaci | 2007 |
Preventive effect of co-administration of water containing magnesium ion on indomethacin induced lesions of gastric mucosa in adjuvant-induced arthritis rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disease Models, Animal; D | 2009 |
Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-R | 2009 |
Anti-inflammatory properties of cryptolepine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum.
Topics: Acetic Acid; Analgesics; Anaphylaxis; Animals; Behavior, Animal; Chromobacterium; Dose-Response Rela | 2010 |
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; | 2009 |
Relative inhibitory activity of bile acids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, and chenodeoxycholic acid inhibition of tumour promotion in mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Bile A | 2009 |
Synthesis and analgesic and anti-inflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives.
Topics: Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoqu | 2009 |
Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats.
Topics: Acute Disease; Animals; Carrageenan; Cystitis; Edema; Hindlimb; Ifosfamide; Indomethacin; Inflammati | 2009 |
Anti-inflammatory activity of a HPLC-fingerprinted aqueous infusion of aerial part of Bidens tripartita L.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Bidens; Carrageenan; Chromatography, High Pressure Li | 2010 |
6-Shogaol inhibits monosodium urate crystal-induced inflammation--an in vivo and in vitro study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Catechols; Crystallization; Dose-Res | 2010 |
Trioxsalen derivatives with lipoxygenase inhibitory activity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Carrageenan; Edema; Female; Fre | 2009 |
Synthesis and biological activities of new substituted thiazoline-quinoline derivatives.
Topics: Acetophenones; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal A | 2009 |
Anti-inflammatory and antipyretic effects of Sonchus oleraceus in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cotton Fiber; Disease Models, Animal; Edema; Fever; | 2010 |
Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonate 5-Lipoxygenase; Arthrit | 2010 |
Late onset spondyloarthropathy mimicking polymyalgia rheumatica.
Topics: Age of Onset; Anti-Inflammatory Agents; Biomarkers; Blood Sedimentation; C-Reactive Protein; Diagnos | 2012 |
Antioxidant and anti-inflammatory activities of polyphenolics from Southeastern U.S. range blackberry cultivars.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ear; Edema; Ferric Compounds; Flavonoids; Fruit; In | 2010 |
[Experimental investigation of antiinflammatory and anesthetic properties of calcium pectate].
Topics: Anesthetics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Granuloma | 2010 |
Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-An | 2010 |
The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo.
Topics: Analgesics; Anemarrhena; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability | 2010 |
Anti-inflammatory and analgesic effects displayed by peptides derived from PKI55 protein, an endogenous protein kinase C inhibitor.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Dose-Response | 2010 |
Anti-inflammatory activity of Trichosanthes cucumerina Linn. in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Response Relationship, | 2010 |
Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.
Topics: Adamantane; Administration, Oral; Animals; Ankle; Ankle Joint; Arthritis, Experimental; Body Weight; | 2011 |
In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Brazil; Disease Models, Animal; Edema; Electropho | 2011 |
Anti-inflammatory activity of Penstemon gentianoides and Penstemon campanulatus.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Edema; Flavonoids; Indometh | 2011 |
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic | 2011 |
Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Commiphora; Dinoprosto | 2011 |
Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Catalase; Edema; Flavanones; Free Radi | 2011 |
The vasoactive potential of kisspeptin-10 in the peripheral vasculature.
Topics: Animals; Blood Circulation; Dose-Response Relationship, Drug; Edema; Endothelin-1; Female; Gene Expr | 2011 |
Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Female; Indomethacin; Male; Nitrates; Nitric | 2011 |
Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Chlorogenic | 2011 |
Anti-inflammatory activities, triterpenoids, and diarylheptanoids of Alnus acuminata ssp. arguta.
Topics: Alnus; Animals; Anti-Inflammatory Agents; Antioxidants; Diarylheptanoids; Drug Evaluation, Preclinic | 2011 |
Methanol extract from mycelium of endophytic fungus Rhizoctonia sp. induces antinociceptive and anti-inflammatory activities in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Indomethacin; Male; Methanol; Mic | 2011 |
Anti-inflammatory and antioxidant activity of Ficus carica Linn. leaves.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Edema; Ficus; Indomethacin; Plant Leaves; Rats; Rat | 2012 |
Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Carrageenan; Cell Line, Tum | 2012 |
Phytochemical and pharmacological evaluation of prop roots of Pandanus fascicularis Lam.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrageenan; Chro | 2011 |
Sesquiterpene lactone, a potent drug molecule from Artemisia pallens wall with anti-inflammatory activity.
Topics: Acetone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Artemisia; Chromatography, High Pressure | 2011 |
Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner.
Topics: Animals; Basophils; Capillary Permeability; Edema; Histamine Antagonists; Indomethacin; Mast Cells; | 2011 |
Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Boswellia; Carrageenan; Chromatography, Liquid; Commi | 2012 |
Anti-inflammatory potential of thienopyridines as possible alternative to NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Line; Cytokines; Dis | 2012 |
Alpinia calcarata Roscoe: a potent antiinflammatory agent.
Topics: Alpinia; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Histamine; Indomethacin; Inflammatio | 2012 |
Early undernutrition is associated with attenuated inflammatory response and alteration in pharmacological efficacy of indomethacin in rats.
Topics: Analysis of Variance; Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Birth Weight; C | 2012 |
Anti-inflammatory effect of piperine in adjuvant-induced arthritic rats--a biochemical approach.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzodioxoles; | 2012 |
Synthesis of 5,6-dichloroindan-1-acids and their tetrazolyl derivatives as analgesic and anti-inflammatory agents.
Topics: Acetic Acid; Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response | 2012 |
Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein.
Topics: Activating Transcription Factor 6; Animals; Anthraquinones; Anti-Inflammatory Agents; Aquaporin 4; A | 2012 |
Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationshi | 2012 |
Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonic Acid; Cymenes; Edema; Female; Indo | 2012 |
Polyphenolic profile and biological activity of Salvia splendens leaves.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Diabetes Mellitus, Experimental; Dis | 2012 |
Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Capil | 2013 |
Anti-inflammatory activity of lycopene isolated from Chlorella marina on type II collagen induced arthritis in Sprague Dawley rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; C-Reactive Protein; Carotenoids; Cerulop | 2013 |
Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Anti-I | 2002 |
Synthesis, antiinflammatory and analgesic activity of new hexahydropyrimidine derivatives.
Topics: Acetic Acid; Administration, Cutaneous; Administration, Oral; Analgesics, Non-Narcotic; Animals; Ant | 2002 |
Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dose-Respons | 2002 |
Enhanced sensitisation of mice with diphtheria tetanus acellular pertussis vaccine to local swelling reaction to the booster immunisation.
Topics: Animals; Antibodies, Bacterial; Antigens, Bacterial; Bordetella pertussis; Diphtheria Toxin; Diphthe | 2002 |
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2002 |
Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms.
Topics: Animals; Antipsychotic Agents; Benzamides; Cyclooxygenase Inhibitors; Edema; Enzyme Inhibitors; Extr | 2002 |
In-vivo and in-vitro anti-inflammatory effect of Echinacea purpurea and Hypericum perforatum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carrageenan; Cyclooxygenase 2; | 2002 |
Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation.
Topics: Animals; Carrageenan; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhib | 2002 |
Butorphanol decreases edema following carrageenan-induced paw inflammation in rats.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Carrageenan; Dose | 2002 |
Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract.
Topics: Acute Disease; Alstonia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Dise | 2002 |
Alpha-monoisostearyl glyceryl ether enhances percutaneous penetration of indometacin in-vivo.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental | 2002 |
A spinal mechanism for the peripheral anti-inflammatory action of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Disease Models, Animal; | 2003 |
Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; | 2002 |
Pharmaco-toxicological study of diterpenoids.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2003 |
The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Celecoxib; Dexamethasone; Dose-Response Relationship | 2003 |
Comparison of two PBR ligands with classical antiinflammatory drugs in LPS-induced arthritis in rats.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Benzodiazepinones; Carrageenan; Dexamethas | 2003 |
Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cecum; Copper; Edema; Electron Spin R | 2003 |
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cyclooxygenase Inhibitors; Diclofenac; | 2003 |
Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Carr | 2003 |
Participation of corticosteroids and effects of indomethacin on the acute inflammatory response of rats fed n-6 or n-3 polyunsaturated fatty acid-rich diets.
Topics: Acute Disease; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageena | 2003 |
Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; DNA; Edema; Hindlimb; Humans; Indomethacin; Jurkat C | 2003 |
Anti-inflammatory and immunomodulatory activities of polysaccharide from Chlorella stigmatophora and Phaeodactylum tricornutum.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chlorella; Ch | 2003 |
Free radical scavenging activity of the alcoholic extract of Trewia polycarpa roots in arthritic rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Ascorbic Acid; Body Weight; Edema; Ethan | 2003 |
Evaluation of anti-inflammatory potential of Pavetta indica Linn. leaf extract (family: Rubiaceae) in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dextrans; Dose- | 2003 |
Sesquiterpene lactone from Wunderlichia crulsiana inhibits the respiratory burst of leukocytes triggered by distinct biochemical pathways.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Brazil; Dose-Response Relationship, Dr | 2003 |
Evaluation of anti-inflammatory activity of chloroform extract of Bryonia laciniosa in experimental animal models.
Topics: Animals; Anti-Inflammatory Agents; Bryonia; Carrageenan; Chloroform; Dextrans; Edema; Exudates and T | 2003 |
Studies on novel 7-acyl-5-chloro-2-oxo-3H-benzoxazole derivatives as potential analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoxazoles; Capillary Perme | 2003 |
Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice.
Topics: Acute Disease; Animals; Arachidonic Acid; Carrageenan; Celecoxib; Croton Oil; Cyclooxygenase 1; Cycl | 2003 |
Interaction of allopurinol and non-steroidal anti-inflammatory drugs on the carrageenan-induced rat paw edema.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dose-Respons | 2003 |
Anti-inflammatory and antiulcerogenic effects of the aqueous extract of Lobaria pulmonaria (L.) Hoffm.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Beverages; Carrageenan; Edema; | 2003 |
ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.
Topics: Acetates; Adrenalectomy; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents | 1963 |
A METHOD FOR MEASURING SWELLING OF HANDS AND FEET. II. INFLUENCE OF NEW ANTI-INFLAMMATORY DRUG, INDOMETHACIN, IN ACUTE GOUT.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Edema; Foot Diseases; Gout; Hand; Humans; Ind | 1963 |
[Inhibition of dexamethasone, indomethacin and resveratrol on matrix metalloproteinase-9 and the mechanism of inhibition].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Croton Oil; Dexamethason | 2003 |
Pharmacological characterization of mouse hind paw oedema induced by Bothrops insularis (jararaca ilhoa) snake venom.
Topics: Animals; Antivenins; Blood Proteins; Bothrops; Crotalid Venoms; Cyclooxygenase Inhibitors; Cyprohept | 2003 |
Synthesis and anti-inflammatory activity of alkyl/arylidene-2-aminobenzothiazoles and 1-benzothiazol-2-yl-3-chloro-4-substituted-azetidin-2-ones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azetidines; Carrageenan; Chemical Phenomena; Chemi | 2003 |
Induction of distinct sets of secretory phospholipase A(2) in rodents during inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Chromans; Edema; Enzyme Induction; | 2003 |
Studies on the anti-inflammatory effect of fluoxetine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyc | 2004 |
Amide derivatives of [6-(5-methyl-3-phenylpyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acids as potential analgesic and anti-inflammatory compounds.
Topics: Acetates; Administration, Oral; Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2004 |
Synthesis and anti-inflammatory activities of N-benzoylamino-1,2,3,6-tetrahydropyridine analogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Carrageenan; Chemical Phenomena; Chemi | 2003 |
Studies on the anti-inflammatory effects of Clerodendron trichotomum Thunberg leaves.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Carrageenan; | 2004 |
Nociceptive and edematogenic responses elicited by a crude bristle extract of Lonomia obliqua caterpillars.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthropod Venoms; Dose-Response Relationship, Drug | 2004 |
Effect of a Korean traditional formulation, Hwaotang, on superoxide generation in human neutrophils, platelet aggregation in human blood, and nitric oxide, prostaglandin E2 production and paw oedema induced by carrageenan in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carrageenan; Cell Degranulation | 2004 |
Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Hepat | 2004 |
Gastric effects of the selective cyclooxygenase-2 inhibitor, celecoxib, in the rat.
Topics: Animals; Aspirin; Carrageenan; Celecoxib; Consciousness; Cyclooxygenase Inhibitors; Edema; Gastric M | 2004 |
In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG).
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimy | 2004 |
Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat.
Topics: Administration, Oral; Analysis of Variance; Animals; Anthocyanins; Anti-Inflammatory Agents, Non-Ste | 2004 |
Isolation of a haemorrhagic protein toxin (SA-HT) from the Indian venomous butterfish (Scatophagus argus, Linn) sting extract.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 2004 |
Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema.
Topics: Adrenergic beta-Antagonists; Animals; Antiemetics; Arachidonic Acid; Bothrops; Bradykinin; Cardiovas | 2004 |
Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Drug Therapy, Combination; Edema; Indo | 2004 |
Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Electroacupuncture; Freund's Adjuvant; Hot | 2004 |
Anti-inflammatory and gastro sparing activity of some new indomethacin derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Evaluation, Preclinical; Edema; | 2005 |
Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cyproheptadine; Dipyrone; Edema; Indomethacin; Inje | 2005 |
[Inflammatory ointment from shea butter and hydro-alcoholic extract of Khaya senegalensis barks (Cailcederat)].
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Croton Oil; Dexamethasone; Disease Mod | 2000 |
3D-QSAR and preliminary evaluation of anti-inflammatory activity of series of N-pyrrolylcarboxylic acids.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2005 |
Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice.
Topics: Animals; Arthritis, Experimental; Bradykinin; Cyclooxygenase Inhibitors; Edema; Enzyme Inhibitors; H | 2005 |
Antiinflammatory activity of the pectic polysaccharide from Comarum palustre.
Topics: Animals; Anti-Inflammatory Agents; Cell Adhesion; Dose-Response Relationship, Drug; Edema; Indometha | 2005 |
Correlations between edema and the immediate and prolonged painful consequences of inflammation: therapeutic implications?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bee Venoms; Edema; Indomethacin; Inflammation; Mal | 2005 |
Lethal, oedema, haemorrhagic activity of spotted butterfish (Scatophagus argus, Linn) sting extract and its neutralization by antiserum and pharmacological antagonists.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cyproheptadine; Edema; Edetic | 2005 |
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; | 2005 |
Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents.
Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; | 2005 |
CC 05, a novel anti-inflammatory compound, exerts its effect by inhibition of cyclooxygenase-2 activity.
Topics: Animals; Anti-Inflammatory Agents; Baculoviridae; Benzenesulfonamides; Carrageenan; Celecoxib; Cyclo | 2005 |
Intra-arterial injection of Mesobuthus tamulus venom elicits cardiorespiratory reflexes involving perivascular afferents.
Topics: Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Dose-Response R | 2005 |
Selective in vivo anti-inflammatory action of the galactolipid monogalactosyldiacylglycerol.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Croton Oil; Cyanobacteria; Dose-Response Relationshi | 2005 |
The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Dinoprostone; | 2005 |
Nonsteroidal antiinflammatory agents-part 2 antiinflammatory, analgesic and antipyretic activity of some substituted 3-pyrazolin-5-ones and 1,2,4,5,6,7-3H-hexahydroindazol-3-ones.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ed | 2006 |
Differential modulation of cell recruitment and acute edema in a model of Polybia paulista venom-induced inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Dose-Response Relations | 2006 |
Anti-inflammatory activity of alkanoids and triterpenoids from Trichodesma amplexicaule Roth.
Topics: Alkanes; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Biological Assay; Boraginaceae; | 2006 |
Anti-inflammatory effect of licofelone against various inflammatory challenges.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response R | 2006 |
Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma leptantha.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Boragina | 2006 |
Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, | 2006 |
Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan.
Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; | 2006 |
Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anticoagulants; Calcium; Cyclooxygenase 2 Inhibitors; Daltepa | 2006 |
Synthesis of beta-hydroxypropanoic acid derivatives as potential anti-inflammatory, analgesic and antimicrobial agents.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Aspergillus | 2006 |
Anti-inflammatory, anti-nociceptive and antipyretic effects of extracts of Phrygilanthus acutifolius flowers.
Topics: Acetic Acid; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non- | 2006 |
[Angiotensin II AT1 receptor antagonists as antiinflammatory and gastric protection drugs].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Benzimidazoles; Biphenyl | 2006 |
Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bradykinin; Carrageenan; D | 2006 |
Rat pain-related responses induced by experimental scorpion BmK sting.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacain | 2006 |
Anti-inflammatory activity of crude extract and fractions of Nectandra falcifolia leaves.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Croton Oil; Dru | 2006 |
Anti-inflammatory effect of bioflora probiotic administered orally or subcutaneously with live or dead bacteria.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bi | 2006 |
Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation.
Topics: Acrylic Resins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Carr | 2006 |
Anti-inflammatory activity of bis(3-aryl-3-oxo-propyl)methylamine hydrochloride in rat.
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Cell Proliferation; Cotton F | 2007 |
Role of cyclooxygenases in oedema-forming activity of bothropic venoms.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Blotting, Western; Bothrops; Crotalid Venom | 2007 |
Synergistic effect of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced paw edema in rats.
Topics: Animals; Carrageenan; Cyclooxygenase Inhibitors; Drug Synergism; Edema; Enzyme Inhibitors; Foot; Ind | 2006 |
Contributions of histamine, prostanoids, and neurokinins to edema elicited by edema toxin from Bacillus anthracis.
Topics: Animals; Antigens, Bacterial; Aprepitant; Bacillus anthracis; Bacterial Toxins; Capillary Permeabili | 2007 |
Design of original bioactive formulations based on sugar-surfactant/non-steroidal anti-inflammatory catanionic self-assemblies: a new way of dermal drug delivery.
Topics: Administration, Topical; Animals; Anions; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; | 2007 |
Analgesic and anti-inflammatory activities of a fraction rich in gaultherin isolated from Gaultheria yunnanensis (FRANCH.) REHDER.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Croton | 2007 |
Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum).
Topics: Abdomen; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Constriction, Pathologic; Dexam | 2007 |
Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2007 |
Local delivery of indomethacin to arthritis-bearing rats through polymeric micelles based on amphiphilic polyphosphazenes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Ca | 2007 |
Apoptotic mimicry: phosphatidylserine liposomes reduce inflammation through activation of peroxisome proliferator-activated receptors (PPARs) in vivo.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Carrageenan; Dose-Response Relationship, Drug; Drug Ad | 2007 |
Antiinflammatory effect of the Indian Ayurvedic herbal formulation Triphala on adjuvant-induced arthritis in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Art | 2007 |
Flavonoids with anti-inflammatory and antinociceptive activity from Cistus laurifolius L. leaves through bioassay-guided procedures.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Biological Assay; Carrageenan; | 2007 |
Antinociceptive and anti-inflammatory steroidal saponins from Dracaena ombet.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose- | 2007 |
Anti-inflammatory and free radical scavenging activities of ethanol extracts of three seeds used as "Bolengguazi".
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cucurbitaceae; Dose-Response Relationship, | 2007 |
Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site.
Topics: Acetylcysteine; Administration, Topical; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents | 2008 |
Preventive effect of water containing magnesium ion on paw edema in adjuvant-induced arthritis rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Arthritis, Experimental; Chromat | 2007 |
Physicochemical characterization, in vitro, and in vivo evaluation of indomethacin-loaded nanocarriers self-assembled by amphiphilic polyphosphazene.
Topics: Acrylamides; Acrylic Resins; Animals; Arthritis; Carrageenan; Dose-Response Relationship, Drug; Drug | 2008 |
Topical anti-inflammatory activities of Vitis rotundifolia (muscadine grape) extracts in the tetradecanoylphorbol acetate model of ear inflammation.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Female; F | 2007 |
Traumatic myositis ossificans as a result of college fraternity hazing.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therapy; Edema; Humans; Indomethac | 2008 |
Antinociceptive profile of 2,3,6-trisubstituted piperidine alkaloids: 3-O-acetyl-spectaline and semi-synthetic derivatives of (-)-spectaline.
Topics: Acetic Acid; Acetylcholine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-S | 2008 |
Structural basis of the anti-inflammatory activity of melatonin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 In | 2007 |
Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice.
Topics: Animals; Anti-Inflammatory Agents; Benzopyrans; Disease Models, Animal; Ear; Edema; Emericella; Fema | 2008 |
Permeation studies of indomethacin from different emulsions for nasal delivery and their possible anti-inflammatory effects.
Topics: Administration, Intranasal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cetomacro | 2008 |
Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis.
Topics: Animals; Anti-Inflammatory Agents; Biological Availability; Carrageenan; Cell Survival; Cells, Cultu | 2008 |
Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Synergism; | 2008 |
Presence of a general irritation and inhibition of a local inflammation.
Topics: Acetates; Animals; Aspirin; Blood; Carrageenan; Coloring Agents; Edema; Female; Formaldehyde; Hypert | 1966 |
Suppressive effects of indomethacin on crystal-induced inflammation in canine joints and on neutrophilic motility in vitro.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis; Blood Flow Velocity; Blood Pressure; Do | 1967 |
Percutaneous absorption and anti-inflammatory activity of indomethacin in ointment.
Topics: Animals; Dose-Response Relationship, Drug; Edema; Erythema; Indomethacin; Male; Ointments; Rats; Rat | 1982 |
On the relationship between ulcerogenic and anti-inflammatory properties of indomethacin.
Topics: Animals; Edema; Indomethacin; Intestinal Diseases; Male; Rats; Rats, Inbred Strains; Ulcer | 1983 |
[Scopolamine and its pharmacological effects on some experimental inflammation tests].
Topics: Animals; Carrageenan; Cellulose; Dextrans; Edema; Flufenamic Acid; Granuloma; Indomethacin; Inflamma | 1980 |
Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment.
Topics: Animals; Burns; Cell Membrane Permeability; Cimetidine; Cold Temperature; Edema; Guanidines; Histami | 1980 |
Pharmacological modification of the edema produced by combined infusions of prostaglandin E1 and bradykinin in canine forelimbs.
Topics: Alprostadil; Animals; Bradykinin; Diphenhydramine; Dogs; Drug Synergism; Edema; Female; Forelimb; Hi | 1982 |
[Interaction of polymorphonuclear leukocytes, bradykinin and carragenin. Transference reaction in the rat].
Topics: Animals; Aspirin; Bradykinin; Carrageenan; Drug Synergism; Edema; Indomethacin; Neutrophils; Phospho | 1982 |
Characterization of the enhanced paw edema response to carrageenan and dextran in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats.
Topics: Animals; Bradykinin; Carrageenan; Cyproheptadine; Dextrans; Dinoprostone; Dioxins; Drug Interactions | 1984 |
Effect of neonatal treatment with capsaicin on carrageenan-induced paw oedema in the rat.
Topics: Animals; Animals, Newborn; Capsaicin; Carrageenan; Edema; Histamine Release; Indomethacin; Male; p-M | 1984 |
ONO-3144, a new anti-inflammatory drug and its possible mechanism of action.
Topics: Animals; Anti-Inflammatory Agents; Autolysis; Capillary Permeability; Edema; Hydrogen Peroxide; Indo | 1983 |
A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat.
Topics: Animals; Carrageenan; Dexamethasone; Dose-Response Relationship, Drug; Edema; Hindlimb; Indomethacin | 1984 |
The effect of incorporation of indomethacin with polyethylene glycol 6000 in a solid dispersion on its in vivo properties in the rat.
Topics: Animals; Carrageenan; Edema; Gastric Mucosa; Indomethacin; Kinetics; Male; Polyethylene Glycols; Rat | 1984 |
Effect of indomethacin on postsurgical edema in rats.
Topics: Animals; Edema; Hydrocortisone; Indomethacin; Injections, Intramuscular; Male; Postoperative Complic | 1983 |
Prophylactic use of indomethacin for prevention of postsurgical complications after removal of impacted third molars.
Topics: Adolescent; Adult; Edema; Female; Humans; Indomethacin; Male; Middle Aged; Molar, Third; Pain, Posto | 1983 |
Pharmacodynamics and toxicology of fenflumizole, a new non-steroidal anti-inflammatory imidazole derivative.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dogs; Edema; Female; Guinea Pigs; Hemodynamics; Hind | 1983 |
Indomethacin-ethanol interactions on acute inflammation.
Topics: Animals; Biological Availability; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema | 1983 |
Effect of forskolin on alterations of vascular permeability induced with bradykinin, prostaglandin E1, adenosine, histamine and carrageenin in rats.
Topics: Adenosine; Alprostadil; Animals; Bradykinin; Bromelains; Capillary Permeability; Carrageenan; Colfor | 1983 |
Potentiation of insulin and tolbutamide of the effect of indomethacin on carrageenan paw edema in the rat.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Blood Pressure; Carrageenan; Drug Synergism; Edema | 1982 |
Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors.
Topics: Animals; Aspirin; Carrageenan; Cyclooxygenase Inhibitors; Edema; Hyperalgesia; Indomethacin; Lysopho | 1981 |
[Long-term indomethacin treatment of ophthalmopathies after Basedow disease in general practice].
Topics: Adult; Diplopia; Edema; Eye Diseases; Eyelid Diseases; Female; Graves Disease; Humans; Indomethacin; | 1982 |
Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Carrageenan; Clonidine; Drug Therapy, | 1983 |
[Fetal hydrops following indomethacin administration during pregnancy].
Topics: Adult; Edema; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Male; Mate | 1983 |
Re-appraisal of the role of histamine in carrageenan-induced paw oedema.
Topics: Animals; Carrageenan; Cimetidine; Edema; Histamine; Indomethacin; Male; Rats; Rats, Inbred Strains; | 1983 |
Plasma 6 keto PGE1 alpha concentration in Raynaud's phenomenon.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Edema; Female; Humans; Indomethacin; Male; Middle Aged; R | 1981 |
Blood vessel reactivity on noradrenaline, vasopressin, and prostaglandin F2 alpha, resp., in the isolated perfused hind legs of rats with edemas or adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Blood Vessels; Dinoprost; Edema; Female; Hindlimb; In V | 1982 |
Piroxicam pharmacologic activity and gastrointestinal damage by oral and rectal route. Comparison with oral indometacin and phenylbutazone.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Migration Inhibition; E | 1981 |
[Comparison of the effect of 3-amino-4-mercapto-6-methylpyridazine with various antiphlogistic agents in rat models of inflammation].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Di | 1982 |
Study of Dieffenbachia-induced edma in mouse and rat hindpaw: respective role of oxalate needles an trypsin-like protease.
Topics: Animals; Bradykinin; Crystallization; Cyproheptadine; Edema; Female; In Vitro Techniques; Indomethac | 1981 |
[Anti-inflammatory effects of acemetacin (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Capillary Permeability; Edema; Erythema; | 1982 |
[Prevention of cystoid macula edema using indomethacin eyedrops].
Topics: Cataract Extraction; Edema; Humans; Indomethacin; Lenses, Intraocular; Macula Lutea; Ophthalmic Solu | 1982 |
Hydrops fetalis caused by maternal indomethacin treatment.
Topics: Adult; Diseases in Twins; Edema; Female; Heart Defects, Congenital; Humans; Indomethacin; Infant, Ne | 1982 |
[Evaluation of nonsteroidal anti-inflammatory drugs (NSAID) intended for use as topical anti-inflammatory drugs].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dose-Response R | 1982 |
Prostaglandins and the eye: rapid transition from basic to applied and implications for expanded clinical consideration.
Topics: Animals; Diabetic Retinopathy; Dogs; Edema; Eye Diseases; Glaucoma; Humans; Indomethacin; Norepineph | 1982 |
Pharmacologic therapy of aphakic cystoid macular edema. A review.
Topics: Administration, Topical; Adrenal Cortex Hormones; Edema; Humans; Indomethacin; Macula Lutea; Prostag | 1982 |
[Anti-inflammatory action of acemetacin (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Edema; Erythema; Female; Granuloma; Hyal | 1980 |
[Causal treatment of corneal vascularization (author's transl)].
Topics: Corneal Diseases; Cysteine; Edema; Glucose; Glycerol; Humans; Indomethacin; Lactates | 1980 |
[Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents].
Topics: Animals; Carbon Tetrachloride; Carrageenan; Edema; Ibuprofen; Indomethacin; Inflammation; Lipid Pero | 1981 |
Interaction of indomethacin and aspirin or mepirizole in rats as shown by gastrointestinal ulcerogenic and anti-inflammatory activities.
Topics: Animals; Aspirin; Biological Transport; Charcoal; Drug Interactions; Edema; Epirizole; Indomethacin; | 1980 |
The effects of levamisole and D-penicillamine on some inflammatory models in vivo and on PG production in vitro.
Topics: Animals; Disease Models, Animal; Edema; In Vitro Techniques; Indomethacin; Inflammation; Leukocytes; | 1981 |
The influence of experimental hypo- and hyperthyroid states on acute and chronic inflammatory reactions: modified response to non-steroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dose-Response Relationship, Drug; Edema; | 1981 |
Anti-inflammatory testing methods: comparative evaluation of mice and rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Cyproheptadine; Edema; Female; | 1981 |
[A device for the drug-capsule administration into the rat stomach and its pharmacological application (author's transl)].
Topics: Animals; Barium Sulfate; Capsules; Catheterization; Edema; Gastrostomy; Indomethacin; Male; Rats; Ra | 1981 |
Indomethacin and CME.
Topics: Aged; Cataract Extraction; Edema; Female; Gastrointestinal Diseases; Humans; Indomethacin; Macula Lu | 1980 |
Indomethacin and CME.
Topics: Cataract Extraction; Edema; Humans; Indomethacin; Macula Lutea; Ophthalmic Solutions; Postoperative | 1980 |
Characteristics of prostaglandin E1 potentiation of inflammatory activity of some agents.
Topics: Adenosine; Animals; Bradykinin; Carrageenan; Drug Synergism; Edema; Histamine; Indomethacin; Inflamm | 1980 |
Late cystoid macular edema in pseudophakia.
Topics: Adrenal Cortex Hormones; Aged; Betamethasone; Cataract Extraction; Edema; Female; Humans; Indomethac | 1980 |
The anti-inflammatory activity of marine natural products--6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate.
Topics: Animals; Anti-Inflammatory Agents; Drug Evaluation, Preclinical; Edema; Homosteroids; Indomethacin; | 1980 |
Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats.
Topics: Administration, Oral; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; | 1995 |
Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema.
Topics: Administration, Cutaneous; Animals; Arachidonic Acid; Calcitonin Gene-Related Peptide; Calcium; Caps | 1993 |
Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis.
Topics: Alprostadil; Animals; Arachidonic Acid; Drug Combinations; Edema; Encephalomyelitis, Autoimmune, Exp | 1994 |
Effect of nonapeptide fragments of uteroglobin and lipocortin I on oedema and mast cell degranulation.
Topics: Animals; Annexin A1; Aristolochic Acids; Carrageenan; Cell Degranulation; Chlorpheniramine; Dexameth | 1994 |
Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin.
Topics: Adrenalectomy; Animals; Anthraquinones; Bradykinin; Capillary Permeability; Cell Degranulation; Dexa | 1995 |
An investigation into the mechanism of capsaicin-induced oedema in rabbit skin.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bradykinin; Calcitonin Ge | 1995 |
Effects of an anti-inflammatory peptide (antiflammin 2) on cell influx, eicosanoid biosynthesis and oedema formation by arachidonic acid and tetradecanoyl phorbol dermal application.
Topics: Acetylglucosaminidase; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 1995 |
Synthesis and antiinflammatory activity of some new thiazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromatography, Thin Layer; Edema; In | 1995 |
Mechanisms of T-kinin-induced increases in macromolecule extravasation in vivo.
Topics: Amino Acid Sequence; Animals; Bradykinin; Cricetinae; Dextrans; Edema; Fluorescein-5-isothiocyanate; | 1993 |
Zymosan-induced arthritis in rats. II. Effects of anti-inflammatory drugs.
Topics: Animals; Arthritis; Cartilage, Articular; Dexamethasone; Edema; Fever; Indomethacin; Knee Joint; Mal | 1995 |
Hyaluronic acid modulates acute and chronic inflammation.
Topics: Acute Disease; Animals; Arthritis, Experimental; Carrageenan; Chronic Disease; Disease Models, Anima | 1994 |
Inhibition of inflammation and gastric damage in rats by copper (II) complexes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Behavior, Animal; Carrageenan; | 1995 |
Collagenase-induced oedema in the rat paw and the kinin system.
Topics: Animals; Arginine; Azepines; Bradykinin; Collagenases; Edema; Female; Heparin; Hindlimb; Indomethaci | 1995 |
Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice.
Topics: Animals; Bothrops; Crotalid Venoms; Dexamethasone; Edema; Edetic Acid; Indomethacin; Mice; Prazosin; | 1995 |
Protective effect of propionyl-L-carnitine against PAF-induced rat paw oedema.
Topics: Animals; Cardiotonic Agents; Carnitine; Carrageenan; Dose-Response Relationship, Drug; Edema; Indome | 1995 |
Conditioned place preference paradigm: a novel approach for analgesic drug assessment against chronic pain.
Topics: Analgesics; Animals; Chronic Disease; Conditioning, Operant; Dizocilpine Maleate; Edema; Hot Tempera | 1994 |
S14080, a peripheral analgesic acting by release of an endogenous circulating opioid-like substance.
Topics: Adrenalectomy; Analgesics; Animals; Arginine; Dipyrone; Drug Tolerance; Edema; Endorphins; Fever; Hy | 1995 |
Synthesis and pharmacological evaluation of oligoethylene ester derivatives as indomethacin oral prodrugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromatography, High Pressure Liquid; | 1994 |
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Ca | 1995 |
Dual inhibition of platelet-activating factor and arachidonic acid metabolism by ajmaline and effect on carrageenan-induced rat paw oedema.
Topics: Ajmaline; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Carbon Radioisotopes; Carrageenan; Ed | 1993 |
Involvement of leukotrienes in allergic inflammation in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; A | 1994 |
Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins.
Topics: Animals; Edema; Ethanol; Gastric Mucosa; Gastrointestinal Hemorrhage; Indomethacin; Male; Prostaglan | 1994 |
Synthesis and anti-inflammatory properties of 1,2-dialkoxy-4-(3-dimethylaminopropionyl)benzenes and their 5-halogeno derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Edema; Foot Inju | 1994 |
Influence of 0-(beta-hydroxyethyl)-rutin on the oedema-inhibiting effect of indomethacin.
Topics: Animals; Anticoagulants; Carrageenan; Drug Synergism; Edema; Hydroxyethylrutoside; Indomethacin; Inf | 1994 |
Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chronic Disea | 1994 |
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Topics: Abscess; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Gene Expressio | 1994 |
Antinociceptive, anti-inflammatory and antipyretic effects of lapidin, a bicyclic sesquiterpene.
Topics: Analgesics; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-S | 1994 |
Avarol and avarone, two new anti-inflammatory agents of marine origin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclohexenes; Edema | 1994 |
Aminopyrazinyl derivatives: synthesis and evaluation of antiinflammatory and related activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Edema; Femal | 1994 |
Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: an experimental study in the rat.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Capillary Permeability; Edema; Indomethacin | 1993 |
Some new benzoxazolinone derivatives with analgesic and anti-inflammatory activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Carrageenan; Crystallization; Dinopr | 1993 |
Anti-inflammatory activity of substituted 1,3,4-oxadiazoles.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Indomethacin; Lethal D | 1994 |
Effect of prostaglandins and superoxide dismutase administration on oxygen free radical production in experimental acute pancreatitis.
Topics: 16,16-Dimethylprostaglandin E2; Acute Disease; Animals; Edema; Enzyme Activation; Free Radicals; Ind | 1993 |
Pharmacological characterization of WAY-121,520: a potent anti-inflammatory indomethacin-based inhibitor of 5-lipoxygenase (5-LO)/phospholipase A2 (PLA2).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoconstriction; Edema; Guinea Pigs; Humans; I | 1993 |
New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note II.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena | 1993 |
T-cell-dependent immunobiological activity of a desmuramyl analog of muramyl dipeptide, adamantylamide dipeptide (AdDP), and D-isoglutamine.
Topics: Adjuvants, Immunologic; Amantadine; Animals; Antilymphocyte Serum; Capillary Permeability; Dexametha | 1993 |
Anti-inflammatory activities of Ph CL28A in rats in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azo Compounds; Blood | 1993 |
Some cellular and pathophysiological correlates of the inflammatory effects of a synthetic immunomodulatory agent, muramyl dipeptide (MDP).
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Antibodies, Monoclonal; Capillary Permeability; Dose-Res | 1993 |
Pharmacological and pharmaceutical properties of freeze-dried formulations of egg albumin, indomethacin, olive oil, or fatty acids.
Topics: Administration, Oral; Animals; Biological Availability; Carrageenan; Drug Carriers; Edema; Fatty Aci | 1993 |
Early perifocal cell changes and edema in traumatic injury of the spinal cord are reduced by indomethacin, an inhibitor of prostaglandin synthesis. Experimental study in the rat.
Topics: Animals; Body Water; Edema; Immunoenzyme Techniques; Indomethacin; Male; Microscopy, Electron; Rats; | 1993 |
Indomethacin, an inhibitor of prostaglandin synthesis attenuates alteration in spinal cord evoked potentials and edema formation after trauma to the spinal cord: an experimental study in the rat.
Topics: Analysis of Variance; Animals; Edema; Evoked Potentials; Indomethacin; Laminectomy; Male; Rats; Rats | 1993 |
Macrolide antibiotics as antiinflammatory agents: roxithromycin in an unexpected role.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Croton Oil; Dis | 1993 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |
Anti-inflammatory activity of Taiwan folk medicine "ham-hong-chho" in rats.
Topics: Animals; Dose-Response Relationship, Drug; Edema; Indomethacin; Inflammation; Male; Medicine, Chines | 1995 |
Anti-inflammatory and analgesic activity of Baccharis trimera: identification of its active constituents.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanols; Carra | 1996 |
Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic Acid; Croton O | 1995 |
Lipid peroxidation and lysosomal integrity in different inflammatory models in rats: the effects of indomethacin and naftazone.
Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ca | 1995 |
Effect of silymarin on different acute inflammation models and on leukocyte migration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Movement; Ear, External; Edema; | 1996 |
Oxaceprol, an atypical inhibitor of inflammation and joint damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dinoprostone | 1996 |
Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cell Division; Cell Wall; | 1996 |
Interaction between nitric oxide and prostaglandin synthesis in the acute phase of allergic conjunctivitis.
Topics: Administration, Topical; Albumins; Animals; Antigens; Capillary Permeability; Conjunctival Diseases; | 1996 |
Zymosan-activated plasma induces paw oedema by nitric oxide and prostaglandin production.
Topics: Animals; Arginine; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Enzyme Inhibi | 1997 |
The role of B1 and B2 kinin receptors in oedema formation after long-term treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG).
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bradykinin R | 1997 |
Anti-inflammatory and antiulcer activity of Teucrium buxifolium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Experimental; Carrag | 1997 |
Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Experimental; C | 1996 |
Relationship between pharmacokinetics and the analgesic effect of indomethacin in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Hindlimb; Indomethacin | 1997 |
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetinae; Cyclo | 1997 |
Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Disease Models, Animal; Drug The | 1997 |
The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant-induced changes in hyperalgesia and allodynia.
Topics: Animals; Cyclooxygenase Inhibitors; Edema; Foot; Freund's Adjuvant; Hyperalgesia; Indomethacin; Isoe | 1997 |
Synthesis of amides with anti-inflammatory and analgesic activities.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Gas Chromatogr | 1997 |
The effects of a triterpene fraction isolated from Crataegus monogyna Jacq. on different acute inflammation models in rats and mice. Leucocyte migration and phospholipase A2 inhibition.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Migrat | 1997 |
Isolated ductal closure in utero diagnosed by fetal echocardiography.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cardiomegaly; Choroid Plexus; Cysts; Ductus Arterios | 1997 |
Mast cell involvement in the rat paw oedema response to 1,8-cineole, the main constituent of eucalyptus and rosemary oils.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Cycl | 1997 |
Evaluation of the antiinflammatory activity of sodium valproate in rats and mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Body Temperature Regulation; Car | 1996 |
Immunopharmacological studies on collagen-induced arthritis in dark Agouti (DA) rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arth | 1997 |
From indomethacin to a selective COX-2 inhibitor. Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromium Radioisotopes; Cyclooxygenas | 1997 |
The pharmacological profile of mouse hind paw inflammation induced by staphylococcal enterotoxin type A.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Capsaicin; Cimetidi | 1997 |
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas | 1997 |
Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ben | 1997 |
Anti-inflammatory activity in mice of extracts from Mediterranean marine invertebrates.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Edema; Female; Indometh | 1998 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1998 |
Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis.
Topics: Aniline Compounds; Animals; Carrageenan; Cysteine; Dermatitis, Contact; Edema; Enzyme Inhibitors; Ep | 1998 |
Synthesis of some novel pyrazole derivatives as potential antiinflammatory agents with minimum ulcerogenic activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Foot; Gastric Mucosa; Indometh | 1998 |
Effect of colchicine on nerve growth factor-induced leukocyte accumulation and thermal hyperalgesia in the rat.
Topics: Animals; Colchicine; Edema; Gout Suppressants; Hot Temperature; Hyperalgesia; Indomethacin; Leukocyt | 1998 |
Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Disease Models, Animal; Ear Diseases; Edema; Fo | 1998 |
Pharmacological analysis of cyclooxygenase-1 in inflammation.
Topics: Animals; Arthritis, Experimental; Blood Platelets; Carrageenan; Celecoxib; Cyclooxygenase 1; Cycloox | 1998 |
[Analgesic and anti-inflammatory activity of saponins of Argania spinoza].
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Edema; Indomethacin; Mice; Pa | 1998 |
ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Benzamides; Carrageenan; Cycloox | 1998 |
Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo).
Topics: Animals; Anti-Inflammatory Agents; Bothrops; Dexamethasone; Diphenhydramine; Dose-Response Relations | 1998 |
Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice.
Topics: Animals; Bradykinin; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Edema; Formald | 1998 |
Amentoflavone, a plant biflavone: a new potential anti-inflammatory agent.
Topics: Administration, Oral; Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents, Non-St | 1998 |
Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene.
Topics: Acetic Acid; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Arthritis, Exp | 1998 |
Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyc | 1999 |
Anti-inflammatory and ulcerogenic effects of 3-(N,N-diethylamino) propylindometacin HCl.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Indomethacin; Male; Prodrugs; Rats; Rats, S | 1997 |
Inhibition of mouse ear edema by steroidal and triterpenoid saponins.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Croton Oil; Ear, External; Edema; Hydrocortison | 1999 |
Mediator-dependent secondary injury after unilateral blunt thoracic trauma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Transfusion; Cerebrovascular Disorders; Cont | 1999 |
Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw.
Topics: Animals; Capillary Permeability; Edema; Indomethacin; Inflammation; Male; Mast Cells; NG-Nitroargini | 1999 |
Mouse ear edema modulation by different propolis ethanol extracts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Ear, External; Edema; Ethanol; F | 1999 |
Combination benefit of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) and dexamethasone or indomethacin in adjuvant arthritic rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1999 |
Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chloroform; Chronic Disease; Dexamethasone; Diseas | 1999 |
Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cytosol; Dinoprost; Dinoprostone; Disease Models, Anima | 2000 |
Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Edema; Hindlimb; Indome | 2000 |
Selective cyclooxygenase-2 (COX-2) inhibitors reduce anti-Mycobacterium antibodies in adjuvant arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Bacterial; Arthritis, Experimental; Bo | 2000 |
Anti-inflammatory effects of fangchinoline and tetrandrine.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylisoquinolines; Cells, Cultured; C | 2000 |
Antiinflammatory effects of seaprose-S on various inflammation models.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1999 |
Intrinsic prostacyclin contributes to exudation induced by bradykinin or carrageenin: a study on the paw edema induced in IP-receptor-deficient mice.
Topics: Animals; Bradykinin; Carrageenan; Cyclooxygenase Inhibitors; Edema; Epoprostenol; Exudates and Trans | 2000 |
Preparation and pharmacodynamic evaluation of liposomes of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Drug Carriers; Edema; | 2000 |
Prediction of the efficacy of cutaneously applied nonsteroidal anti-inflammatory drugs from a lipophilic vehicle.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Ed | 2000 |
Antinociceptive and anti-oedematogenic properties of astilbin, taxifolin and some related compounds.
Topics: Acetaminophen; Acetates; Analgesics; Analgesics, Non-Narcotic; Animals; Aspirin; Edema; Flavonoids; | 2000 |
Genetic factors determine the contribution of leukotrienes to acute inflammatory responses.
Topics: Acute Disease; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Crosses, Genetic; Ear, Extern | 2000 |
Evaluation of analgesic and anti-inflammatory activity of novel beta-lactam monocyclic compounds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Female; Humans; Indomethacin; M | 2000 |
Anti-inflammatory effect of FR140423, a novel selective cyclo-oxygenase-2 inhibitor, in rat adjuvant arthritis without gastrointestinal side effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 2; Edema; | 2000 |
Synthesis and pharmacological evaluations of N-(substituted benzoylamino)-5-carbethoxymethyl-1,2,3,6-tetrahydropyridines as potential antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Dose-Response Relationship | 2000 |
Treatment of adjuvant arthritis in mice with yeast superoxide dismutase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Arthritis, Experimental; Edema; Erythr | 2000 |
Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 2; Cycloox | 2000 |
Suppression of adjuvant arthritis of rats by a novel matrix metalloproteinase-inhibitor.
Topics: Amino Acids; Animals; Antineoplastic Agents; Arthritis, Experimental; Biphenyl Compounds; Body Weigh | 2000 |
A new technique for the analysis of endogenous mediators released following thermal injury.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Dinoprostone; Disease Models, Ani | 2001 |
A reduction of tumor necrosis factor-alpha in paw exudate of lipopolysaccharide treated rats by nimesulide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Edema; Exudates and Tra | 2001 |
Evidence for bradykinin mediation of carrageenin-induced inflammatory pain: a study using kininogen-deficient Brown Norway Katholiek rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Disease Models, Animal; E | 2001 |
Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom.
Topics: Animals; Bradykinin; Crotalid Venoms; Cytokines; Edema; Hyperalgesia; Indomethacin; Male; Rats; Rats | 2001 |
Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adjuvants, Immunologic; Administration, Cutaneous; Animals; Anti-I | 2001 |
Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Disease Models, An | 2001 |
Changes in prostaglandin E2 (PGE2) levels in paw exudate, stomach and kidney of arthritic rats: effects of flosulide.
Topics: Animals; Arthritis, Experimental; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhi | 2001 |
Topical anti-inflammatory activity of a new germacrane derivative from Achillea pannonica.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Croton Oil; D | 2001 |
New acetophenone glucosides isolated from extracts of Helichrysum italicum with antiinflammatory activity.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Benzopyrans; beta-Gluco | 2001 |
Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Calcium Channels, T-Type | 2001 |
Anti-inflammatory activity of a novel selective cyclooxygenase-2 inhibitor, FR140423, on type II collagen-induced arthritis in Lewis rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis; Collagen; Cyclooxygen | 2001 |
Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat.
Topics: Acute Disease; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Cannabinoid Rece | 2002 |
An investigation of the antiinflammatory effects of an extract from Cladonia rangiformis HOFFM.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Edema; Formaldehyd | 2002 |
Modulation of inflammatory paw oedema by cysteamine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Corticotropin-Releasing Ho | 2002 |
Effects of prostaglandin E2 methyl analogues on the anti-inflammatory and gastric erosive activity of indomethacin.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Drug Interactions; Edema; Gastric Mucosa; Indomethac | 1976 |
The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chelating Agents; Copper; Edema | 1976 |
Letter: Indomethacin and closure of the ductus arteriosus.
Topics: Animals; Ductus Arteriosus; Ductus Arteriosus, Patent; Edema; Female; Humans; In Vitro Techniques; I | 1975 |
Proceedings: Prostaglandins in burn induced acute oligo-anuria and oedema.
Topics: Animals; Anuria; Burns; Dogs; Edema; Female; Indomethacin; Inflammation; Male; Oliguria; Prostagland | 1975 |
The anti-inflammatory actions of tilorone hydrochloride.
Topics: Abscess; Administration, Oral; Adrenal Glands; Animals; Anti-Inflammatory Agents; Arthus Reaction; C | 1975 |
Prevention of cystoid macular edema after lens extraction by topical indomethacin (I). A preliminary report.
Topics: Administration, Topical; Aged; Cataract Extraction; Edema; Humans; Indomethacin; Lens, Crystalline; | 1977 |
[Anti-inflammatory property of 6-chloro-5-cyclohexyl-1-indancarboxylic acid (TAI-284) (author's transl)].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Capillary Permeability; Death, Sud | 1977 |
Prevention of cystoid macular edema after lens extraction by topical indomethacin (III) radioimmunoassay measurement of prostaglandins in the aqueous during and after lens extraction procedures.
Topics: Aged; Aqueous Humor; Cataract Extraction; Edema; Female; Humans; Indomethacin; Macula Lutea; Male; M | 1978 |
Comparative pharmacology of a 1:10 combination of indomethacin-sodium salicylate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Castor Oil; Diarrhea; Ede | 1979 |
On the ineffectiveness of indomethacin against rheumatoid swelling [proceedings].
Topics: Animals; Edema; Indomethacin; Lymphocytes; Rabbits; Skin Transplantation; Transplantation, Homologou | 1977 |
The effect of indomethacin pretreatment on aphakic cystoid macular edema.
Topics: Adult; Aged; Aphakia, Postcataract; Edema; Humans; Indomethacin; Macula Lutea; Middle Aged; Retinal | 1979 |
Topical indomethacin in treatment and prevention of intraocular inflammation--with special reference to lens extraction and cystoid macular edema.
Topics: Animals; Edema; Humans; Indomethacin; Inflammation; Intraocular Pressure; Lenses, Intraocular; Macul | 1979 |
Studies on the effects of anti-inflammatory action of benzoyl-hydrotropic acid (ketoprofen) and other drugs, with special reference to prostaglandin synthesis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Edema; Foot; Indomethacin; Ketoprofen; Male | 1979 |
Effect of inhibiting prostaglandin synthesis on edema formation and albumin leakage during thermal trauma in the rat.
Topics: Albumins; Animals; Body Water; Burns; Capillary Permeability; Drug Evaluation, Preclinical; Edema; F | 1979 |
Increase in body temperature during carrageenin-induced paw oedema in the rat. Effect of non-steroid anti-inflammatory substances and essential fatty acid deficiency.
Topics: Acetaminophen; Aging; Animals; Anti-Inflammatory Agents; Brain Chemistry; Carrageenan; Edema; Fatty | 1979 |
Synthesis and anti-inflammatory properties of some pyrrolo(1H,3H)[3,4-d]pyrimidin-2-ones and pyrrolo(1H,6H)[3,4-d]pyrimidin-2-ones.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Female; Indomethacin; Ma | 1979 |
[Pharmacological studies of 2-(5H-(1)benzopyrano[2,3-b]pyridin-7-yl)propionic acid (Y-8004). (3) Its interaction with anti-inflammatory agents].
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Dose-Response Relationship, Dru | 1977 |
[On the efficiency of new antiinflammatory agents. A comparative study (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Carrageenan; Diclofenac; Edema; Fenoprofen | 1977 |
[Prostaglandins as a causative factor of the cystoid macular edema after the lens extraction (II) (author's transl)].
Topics: Aged; Aqueous Humor; Cataract Extraction; Edema; Humans; Indomethacin; Macula Lutea; Middle Aged; Pr | 1977 |
Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Benzoxazines; Drug Evaluation, Preclinical; Edema; Hydro | 1978 |
Indomethacin: relationship between ulcerogenic and anti-inflammatory properties. I. Effects of an intestinal lesion-preventing fat-free diet on anti-edema and anti-granuloma properties of indomethacin in the rat.
Topics: Animals; Body Weight; Dietary Fats; Edema; Fatty Acids, Essential; Granuloma; Indomethacin; Inflamma | 1978 |
Relationship between oedema and plasma exudation in rat paw carrageenin inflammation.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Exudates and Transudates; Indomethaci | 1978 |
Prophylaxis of aphakic cystoid macular edema using topical indomethacin.
Topics: Administration, Topical; Aged; Aphakia, Postcataract; Edema; Fluorescein Angiography; Follow-Up Stud | 1978 |
The significance of inhibition of prostaglandin synthesis in the selection of non-steroidal anti-inflammatory agents.
Topics: Analgesia; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperature; Cyclooxygenase Inhibitors; | 1975 |
Flumizole, a new nonsteroidal anti-inflammatory agent.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Biological Availability; Cyclooxygenase Inh | 1975 |
Anti-inflammatory properties of griseofulvin.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Migration Inhibition; Dose-Response Relationshi | 1977 |
Pharmacology of a new non-steroidal, anti-inflammatory agent: 6,11-dihydro-11-oxodibenz [b, e] oxepin-2-acetic acid (HP 549).
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dibenzoxepins; Ede | 1977 |
Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Cell Movement; Edema; Fenoprofen; Ibuprofen | 1976 |
Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Edema; Female; Freund's Adjuvant; Hyp | 1976 |
Quantitative studies of the pathway to acute carrageenan inflammation.
Topics: Acute Disease; Animals; Carrageenan; Chemotaxis; Cyproheptadine; Disease Models, Animal; Edema; Indo | 1976 |
[A patient with edemas].
Topics: Adult; Albumins; Edema; Female; Furosemide; Glomerular Filtration Rate; Humans; Indomethacin; Infusi | 1976 |
Inhibition of the diarrheal and cardiac actions of arachidonic acid by fenclorac, a new anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Diarrhea; Dose-Response Relationship, Drug; Ed | 1976 |
Antioxidants as agents potentiating the antiinflammatory action of indomethacin.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cattle; Drug Synergism; Edema; Indomethacin; Male; | 1976 |
Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cap | 1975 |
[Pharmacological studies of 2-(5H-(1)benzopyrano(2,3-b)pyridin-7-yl)propionic acid (Y-8004). (I) Anti-inflammatory, analgesic and antipyretic actions].
Topics: Adrenal Cortex; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability | 1975 |
[Experimental studies on the possibility of influencing mast cells in experimental carrageenin-induced rat paw edema. Histological study on the effects of some non-steroidal anti-inflammatory agents (author's transl)].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Cell Count; Edema; Indometha | 1976 |
Floctafenine, a new non-narcotic analgesic.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Dextropropoxyphene; D | 1975 |
Chemistry and pharmacology of naproxen.
Topics: Administration, Oral; Adrenalectomy; Animals; Aspirin; Carrageenan; Drug Evaluation, Preclinical; Ed | 1975 |
Some pharmacological properties of 2-aryl-1,3-indandione derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticoagulants; Antitussive Agents; Drug Evaluation, | 1975 |
The effect of indomethacin on tooth extraction wound healing in rats.
Topics: Animals; Bone Regeneration; Edema; Indomethacin; Male; Rats; Tooth Extraction; Wound Healing | 1975 |
Biological properties of a new non-steroidal anti-inflammatory drug: etoclofene.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Edema; Female; Guinea Pigs; Indom | 1975 |
Are platelets important in inflammation?
Topics: Animals; Blood Platelets; Carrageenan; Edema; Female; Immune Sera; Indomethacin; Inflammation; Passi | 1975 |
Characteristic features of actinomycin D-induced paw inflammation of the rat.
Topics: Acid Phosphatase; Animals; Aspirin; Capillary Permeability; Dactinomycin; Dose-Response Relationship | 1975 |
The activity of suprofen on nystatin-induced paw oedema in rats.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dose-Response Relationship, Drug; Drug Evaluation, Precl | 1975 |
Inflammatory mechanisms in the passive cutaneous anaphylactic reaction in the rabbit: evidence that novel mediators are involved.
Topics: Animals; Aprotinin; Blood Coagulation Factors; Bradykinin; Complement C5a; Dinoprostone; Edema; Fluo | 1992 |
Synthesis and anti-inflammatory activity of 2-pyridyl-2-thiobenzothiazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cattle; Dinoprostone; Edema; Free Rad | 1992 |
Measurement of MPO activity as model for detection of granulocyte infiltration in different tissues.
Topics: Animals; Carrageenan; Dexamethasone; Ear; Edema; Guinea Pigs; Hindlimb; Indomethacin; Inflammation; | 1992 |
Anti-inflammatory and analgesic effects of magnolol.
Topics: Adrenalectomy; Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Dexamethasone; Edema; | 1992 |
PLA2-induced oedema in rat skin and histamine release in rat mast cells. Evidence for involvement of lysophospholipids in the mechanism of action.
Topics: Animals; Aristolochic Acids; Cytoplasmic Granules; Dexamethasone; Edema; Histamine Release; In Vitro | 1992 |
Pituitary adenylate cyclase activating polypeptide is a potent vasodilator and oedema potentiator in rabbit skin in vivo.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Drug Synergism; Edema; Indomethacin; Iodine Ra | 1992 |
Differences in proinflammatory activity of several immunomodulatory derivatives of muramyl dipeptide (MDP) with special reference to the mechanism of the MDP effects.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Edema; Foot; Indomethacin; Infla | 1992 |
Anti-inflammatory, analgesic, and antipyretic effects and gastrointestinal toxicity of the new anti-inflammatory drug N-(3-[3-(piperidinylmethyl)phenoxy]propyl)-carbamoylmethylthio ]ethyl 1-(p-chlorobenzoyl) 5-methoxy-2-methyl-3-indolylacetate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capillary Permeability; E | 1992 |
Antiinflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Comparative studies with indomethacin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Carrageenan; Dige | 1992 |
Therapeutic effect of Ga-Al-As diode laser irradiation on experimentally induced inflammation in rats.
Topics: Aluminum; Animals; Arsenic; Blood Proteins; Body Water; Capillary Permeability; Carrageenan; Dermati | 1992 |
Fuscoside: an anti-inflammatory marine natural product which selectively inhibits 5-lipoxygenase. Part I: Physiological and biochemical studies in murine inflammatory models.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arabinose; Diterpenes; E | 1992 |
The effect of indomethacin on anthralin inflammation.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anthralin; Dermatitis, Contact; Edema; Erythema; F | 1992 |
Inflammatory effects of Salmonella typhimurium porins.
Topics: Animals; Bacterial Outer Membrane Proteins; Complement Activation; Dexamethasone; Edema; Epoprosteno | 1990 |
Increased negativity of interstitial fluid pressure contributes to development of oedema in rat skin following application of xylene.
Topics: Animals; Aprotinin; Edema; Extracellular Space; Indomethacin; Pressure; Rats; Rats, Inbred Strains; | 1990 |
Increased negativity of interstitial fluid pressure during the onset stage of inflammatory edema in rat skin.
Topics: Anaphylaxis; Animals; Capillary Permeability; Cyproheptadine; Dermatitis; Dextrans; Edema; Female; H | 1991 |
Carbonic anhydrase inhibitors are antiarthritic in the rat.
Topics: Acetazolamide; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis | 1991 |
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoquinones; Capillary | 1991 |
Effect of etodolac, a new nonsteroidal anti-inflammatory drug, in MRL/lpr mice with articular lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cartilage, Articular; Edema; Etodolac; | 1991 |
Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 1st communication: inhibitory effects on mouse paw edema.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Concanavalin A; Edema; Female; Foot; | 1991 |
Extract and compounds obtained from Mandevilla velutina inhibit arachidonic acid-induced ear oedema in mice, but not rat stomach contraction.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic | 1991 |
Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil.
Topics: Animals; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Edema; Gerbillinae; Indomethacin; | 1991 |
Characteristics and modulation of dithranol (anthralin)-induced skin irritation in the mouse ear model.
Topics: Administration, Topical; Adrenal Cortex Hormones; Animals; Anthralin; Anti-Inflammatory Agents, Non- | 1991 |
[The renal systems regulating water-electrolyte balance in the nephrotic syndrome].
Topics: Adolescent; Adult; Chronic Disease; Dopamine; Edema; Glomerular Filtration Rate; Heparin; Humans; In | 1991 |
Antinociceptive and anti-inflammatory activity of a novel quipazine derivative (AAL-13): a selective inhibitor of 5-hydroxytryptamine reuptake.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Indometha | 1990 |
Antiinflammatory properties of E5090, a novel orally active inhibitor of IL-1 generation.
Topics: Acrylates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Collagen; Edem | 1991 |
Steroid-saving potency of nonsteroidal antiinflammatory agents--a reevaluation with the new agent CGP 28238 in rat inflammatory models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dexamethasone; Drug Syner | 1991 |
Pharmacological characterization of polycation-induced rat hind-paw oedema.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arginine; Azepines; Dexametha | 1990 |
Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema; Ethamsylat | 1990 |
Research on heterocyclic compounds. XXVII. Synthesis and antiinflammatory activity of 2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan; Edema; Female; Human | 1990 |
Ultraviolet radiation suppresses mouse-ear edema induced by topical application of arachidonic acid.
Topics: Administration, Topical; Animals; Arachidonic Acids; Benzoquinones; Cell Count; Disease Models, Anim | 1990 |
Interleukin-6 serum levels correlate with footpad swelling in adjuvant-induced arthritic Lewis rats treated with cyclosporin A or indomethacin.
Topics: Animals; Arthritis; Arthritis, Experimental; Cyclosporins; Disease Models, Animal; Edema; Foot; Indo | 1990 |
Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 1990 |
Cellular and biochemical characterization of the anti-inflammatory effects of DuP 654 in the arachidonic acid murine skin inflammation model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Arachidonic Acid; Arac | 1990 |
Topical antiinflammatory effects of Euphorbia prostrata on carrageenan-induced footpad oedema in mice.
Topics: Acetates; Administration, Topical; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Female; In | 1990 |
Anti-inflammatory activity of some copper(II) complexes.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 1990 |
Zinc monoglycerolate: a slow-release source of zinc with anti-arthritic activity in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Auranofin; Biological Ava | 1990 |
Inhibitory effect of indomethacin farnesil, a novel antiinflammatory prodrug, on carrageenin-induced inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Edema; Exudates and Tra | 1990 |
Anti-inflammatory effect of saikogenin A.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; | 1986 |
Inhibition of arachidonic acid-induced ear oedema as a model for assessing topical anti-inflammatory compounds.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Cyclooxygenas | 1987 |
Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adrenalectomy; Animals; Annexins; Anti | 1989 |
[Anti-inflammatory, analgesic and antipyretic effect of various plant extracts and their combinations in an animal model].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Carrageenan; Dextrans; Edema; Gossy | 1989 |
N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.
Topics: Acetophenones; Animals; Bronchi; Chemical Phenomena; Chemistry; Constriction, Pathologic; Cyclooxyge | 1989 |
Systemic interleukin I administration suppresses arachidonic acid-induced ear oedema in the mouse.
Topics: Animals; Arachidonic Acids; Dose-Response Relationship, Immunologic; Ear Diseases; Edema; Female; In | 1989 |
Anti-inflammatory evaluation of a hydroalcoholic extract of black currant leaves (Ribes nigrum).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; France; Gastric Mucosa | 1989 |
Pharmacological evaluation of rat paw oedema induced by Bothrops jararaca venom.
Topics: Animals; Captopril; Crotalid Venoms; Dexamethasone; Edema; Hot Temperature; Indomethacin; Male; Maso | 1989 |
Formation of oedema and accumulation of eosinophils in the guinea pig lung. Inhibition by inhaled beta-stimulants.
Topics: Acetylcholine; Animals; Benzimidazoles; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Capillary Per | 1989 |
Pharmacological activity, blood and tissue levels of indomethacin after single oral administration of two long-acting forms in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressur | 1989 |
Topical anti-inflammatory activity of a new acylated flavonoid.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Coumarins; Edema; Flavonoids; Granulocyt | 1989 |
Pharmacological activity of the essential oil of Bupleurum gibraltaricum: anti-inflammatory activity and effects on isolated rat uteri.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicyclic Monoterpenes; Edema; Femal | 1989 |
The pharmacological profile of CGP 28238, a highly potent anti-inflammatory compound.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Gastrointestinal H | 1989 |
Morphine inhibits the carrageenan-induced oedema and the chemoluminescence of leucocytes stimulated by zymosan.
Topics: Animals; Carrageenan; Edema; Female; In Vitro Techniques; Indomethacin; Leukocytes; Luminescent Meas | 1985 |
Analgesic and anti-inflammatory activities in rats of alpha-(3,5-di-t-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), and its intestinal damage.
Topics: 4-Butyrolactone; Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 1986 |
The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Carrageenan; Edema | 1987 |
Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia.
Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Bucladesine; Carrageenan; Dinoprostone; Di | 1985 |
Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2.
Topics: Animals; Aorta, Thoracic; Body Weight; Dietary Fats; Dinoprostone; Edema; Eicosapentaenoic Acid; Epo | 1985 |
Ebselen: a new approach to the inhibition of peroxide-dependent inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Azoles; Edema; Female; Indomethacin; Inflammation; | 1987 |
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition.
Topics: Animals; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Ibuprofen; Imidazoles; Indomethac | 1986 |
Correlation between mouse skin inflammation induced by arachidonic acid and eicosanoid synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Capillary Permeability; Dermatitis, Contact; Dinoprost | 1986 |
Influence of Epilobium extracts on prostaglandin biosynthesis and carrageenin induced oedema of the rat paw.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carrageenan; Edema; Female; Indomethacin; Plant Extrac | 1986 |
Analysis of tumor-promoter-induced inflammation in rats: participation of histamine and prostaglandin E2.
Topics: Animals; Capillary Permeability; Dinoprostone; Edema; Histamine; Indomethacin; Inflammation; Lyngbya | 1987 |
Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Dexamethasone; Edema; Female; | 1988 |
Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Croton Oil; Cyclooxygenase Inhibitors; Edema; Flav | 1988 |
Ex vivo effects of nonsteroidal antiinflammatory drugs on arachidonic acid metabolism in neutrophils from a reverse passive Arthus reaction.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthus Reaction; Calcimycin; Edema; Guanidines; Indome | 1985 |
Indomethacin and dexamethasone treatment in experimental neoplastic spinal cord compression: Part 2. Effect on edema and prostaglandin synthesis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Body Water; Dexamethasone; Dinoprostone; Edema; Indomethacin; | 1988 |
[Circadian fluctuations in the development of carrageenan-induced paw edema in the rat and in its inhibition by indomethacin].
Topics: Animals; Circadian Rhythm; Edema; Female; Foot Diseases; Indomethacin; Rats; Rats, Inbred Strains; R | 1988 |
Lipid peroxidation, free radicals and experimental inflammation.
Topics: Animals; Diclofenac; Disease Models, Animal; Edema; Free Radicals; Indomethacin; Inflammation; Lipid | 1988 |
Indomethacin and dexamethasone treatment in experimental neoplastic spinal cord compression: Part 1. Effect on water content and specific gravity.
Topics: Animals; Body Water; Dexamethasone; Edema; Indomethacin; Rats; Rats, Inbred F344; Specific Gravity; | 1988 |
Ear swelling in response to UVB irradiation.
Topics: Animals; Betamethasone; Cimetidine; Diphenhydramine; Ear, External; Edema; Erythema; Indomethacin; M | 1986 |
Pharmacological profiles of 2-carboxyphenyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate and 2-[(2-carboxyphenoxy)-carbonyl]phenyl-1-(4-chlorobenzoyl)-5-meth oxy-2- methylindole-3-acetate, new antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1986 |
Pharmacological activity of FPP028 (2-phenylpyrazolo-4-ethyl-4,7-dihydro [1,5a]pyrimidin-7-one) a new non-steroid anti-inflammatory agent.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1986 |
Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1987 |
Effect of auranofin treatment on aberrant splenic interleukin production in adjuvant arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Auranofin; Dru | 1987 |
Pharmacological activity of some pyrrolo and pyrazolo pyrimidine derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Humans; In Vitro Techniques; I | 1987 |
Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid. 1st communication: inhibitory effects of rat paw edema.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Benzopyrans; Benzothiepins; Edema; Indomethacin; M | 1986 |
Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl]propionic acid. 4th communication: inhibitory effects on rat adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Benzopyrans; Benzothiepins; B | 1986 |
Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dexamethasone; Edema; Indomethacin; Inflammation; Male; | 1987 |
Mouse paw edema. A new model for inflammation?
Topics: Animals; Carrageenan; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Edema | 1987 |
The anti-inflammatory effect of a crude aqueous extract of the root bark of "Ficus elastica" in the rat.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Carrageenan; Edema; Female; I | 1986 |
[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (1). Anti-inflammatory effects].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Capillary Permeability; Carrageenan; Ed | 1986 |
Turpentine-induced acute inflammatory response in Gallus gallus: oedema, vascular permeability and effects of non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Chickens; Edema; Indometha | 1986 |
Premature closure of the ductus arteriosus causing intra-uterine death. A case report.
Topics: Adult; Ductus Arteriosus; Edema; Female; Fetal Death; Humans; Indomethacin; Obstetric Labor, Prematu | 1986 |
Inhibitory effects of a novel synthetic protease inhibitor, FUT-175, on the paw edema in rats and zymosan-induced complement activation in vitro.
Topics: Animals; Benzamidines; Complement Activation; Edema; Guanidines; In Vitro Techniques; Indomethacin; | 1986 |
[Pharmacological studies of N-(2-mercapto-2-methylpropanoyl)-L-cysteine (SA96). V. Effects of SA96 in combination with indomethacin or prednisolone on adjuvant arthritis in rats].
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Blood Proteins; Blood Sedimen | 1985 |
[Anti-inflammatory effect of topically applied pranoprofen-gel].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Benzopyrans; Capillary Permeability; Ede | 1985 |
Phlogistic activity of leukotriene D4 in the mouse.
Topics: Animals; Capillary Permeability; Dose-Response Relationship, Drug; Edema; Extravasation of Diagnosti | 1986 |
Vascular reactions during electrical stimulation. Vital microscopy of the hamster cheek pouch and the rabbit tibia.
Topics: Animals; Capillary Permeability; Cheek; Cricetinae; Edema; Electric Stimulation; Electromagnetic Fie | 1985 |
Anti-inflammatory activity of S-adenosyl-L-methionine in animal models: possible interference with the eicosanoid system.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Hydrocortisone; Indomethacin; Inflammation; M | 1985 |
Mechanism of anthralin inflammation. I. Dissociation of response to clobetasol and indomethacin.
Topics: Adult; Aged; Anthracenes; Anthralin; Betamethasone; Clobetasol; Dermatitis, Contact; Edema; Erythema | 1985 |
Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats.
Topics: Animals; Carrageenan; Edema; Female; Indomethacin; Lipid Peroxides; Rats; Stomach Ulcer; Time Factor | 1985 |
Edemagenic activity of aqueous form of muramyl dipeptide (MDP) in rats.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Body Weight; Dose-Response Relationship, Drug; Edema; Fo | 1985 |
Gastric mucosal damage induced by non-steroid anti-inflammatory agents in rats of different ages.
Topics: Age Factors; Animals; Anti-Inflammatory Agents; Aspirin; Body Weight; Dose-Response Relationship, Dr | 1972 |
Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Burns; Carrageenan; Edema; Histamine H1 Antagonists; Ind | 1973 |
2-(2,4-dichlorophenoxy) phenylacetic acid (fenclofenac): one of a novel series of anti-inflammatory compounds with low ulcerogenic potential.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemical Phenomena; Chemistry; Disease Mod | 1974 |
[Anti-inflammatory principle synthesized by a strain of Serratia sp].
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Aspirin; Bromelains; Carrageenan; Chymotrypsin; Ed | 1969 |
Study of biochemical effects of anti-inflammatory drugs in carrageenin induced oedema and cotton pellet granuloma.
Topics: Adenosine Triphosphatases; Alanine Transaminase; Animals; Aspartate Aminotransferases; Brain; Edema; | 1968 |
[Drug therapy of postoperative and post-traumatic edemas in orthopedics].
Topics: Congenital Abnormalities; Edema; Fracture Fixation; Humans; Indomethacin; Limb Deformities, Congenit | 1968 |
[Pharmacology of antirheumatic drugs].
Topics: Adenosine Triphosphate; Analgesics; Animals; Anti-Inflammatory Agents; Central Nervous System; Chemi | 1969 |
Antiinflammatory activities of 2-acetyl- and 2-(1-hydroxyethyl)-4-(3-(dimethylamino)propyl)-3,4-dihydro-3-phenyl-2H-1,4-benzothiazine.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthus Reaction; Cell Membrane; DNA; Dogs; Edema; Ence | 1973 |
Isolation of the anti-inflammatory principles from Achillea millefolium (Compositae).
Topics: Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Aspirin; Chromatography; Colorimetry | 1969 |
[Anti-inflammatory drugs].
Topics: Adrenocorticotropic Hormone; Aminobenzoates; Anti-Inflammatory Agents; Dental Pulp Capping; Edema; E | 1971 |
[Efficacy of different antiphlogistic agents with respect to carrageenan-inflammation, compared with other models of inflammation].
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; D | 1971 |
Interaction of aspirin with nonsteroidal anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Drug Antagonism; Edema; Indomethacin; Male; | 1968 |
[General pharmacological properties of methiazinic acid (16091 RP)].
Topics: Abscess; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Autonomic Nervous Syste | 1969 |
[Pharmacological study of phenethyl-8-oxa-1-diaza-3,8-spiro(4,5)decanone-2 hydrochloride or fenspiride (JP 428)].
Topics: Anaphylaxis; Anesthesia; Animals; Anti-Inflammatory Agents; Atropine; Autonomic Nervous System; Bron | 1969 |
Anti-inflammatory, analgesic and antipyretic activities of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284).
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Bronchodilator Agents; Capillary Permeabil | 1971 |
Nonsteroidal antiinflammatory agents. 1.2,4-Diphenylthiazole-5-acetic acid and related compounds.
Topics: Acetates; Albumins; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzaldehydes; Bradyki | 1974 |
Preparation and antiinflammatory activity of some nonacidic trisubstituted imidazoles.
Topics: Administration, Oral; Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Carrageenan; | 1974 |
Editorial: The trainer's sponge.
Topics: Athletic Injuries; Chymotrypsin; Edema; Hematoma; Humans; Indomethacin; Male; Physical Therapy Modal | 1974 |
Carrageenin hyperthermia in rats.
Topics: Animals; Aspirin; Body Temperature; Carrageenan; Dose-Response Relationship, Drug; Edema; Female; Fe | 1974 |
Species differences in susceptibility to the gastro-ulcerogenic action of anti-inflammatory agents.
Topics: Administration, Oral; Ambystoma; Animals; Anti-Inflammatory Agents; Cricetinae; Dose-Response Relati | 1974 |
[Pharmacologic properties of a new, nonsteroidal anti-inflammatory agent, bucloxic acid (804 CB)].
Topics: Administration, Oral; Adrenal Glands; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Cycl | 1974 |
Antiinflammatory activity and other pharmacological properties of phthalazino(2,3-b)phthalazine-5,12(7H, 14H)-dione (Diftalone).
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Blood Pressure; Diuresis; Drug Ev | 1974 |
Effects of anti-inflammatory drugs on prostaglandin biosynthesis.
Topics: Acetaminophen; Aldosterone; Animals; Anti-Inflammatory Agents; Aspirin; Azathioprine; Benzoates; Bio | 1972 |
[Anti-inflammatory agents in dentistry].
Topics: Adult; Anti-Inflammatory Agents; Chymotrypsin; Edema; Female; Fluphenazine; Humans; Indomethacin; In | 1974 |
Synthesis and pharmacology of a novel anti-inflammatory agent, ID-1619.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Capillary Permeability; Chemical Phenomena | 1972 |
Pharmacology of a new non-steroidal anti-inflammatory agent 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one (W-2395).
Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Benzoxazi | 1974 |
Anti-inflammatory polysaccharide produced by Serratia piscatorum.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Edema; Granuloma; Hydrocortisone; Indicators and | 1974 |
Pharmacologic evaluation of tolectin (tolmetin, mcn-2559) and mcn-2891, two anti-inflammatory agents.
Topics: Acetylcholine; Analysis of Variance; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheuma | 1973 |
Letter: An anti-inflammatory peptide from bee venom.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Bees; Carrageenan; Dexamethaso | 1973 |
Prostaglandins, aspirin-like drugs and the oedema of inflammation.
Topics: Animals; Bradykinin; Carrageenan; Drug Synergism; Edema; Histamine; Indomethacin; Inflammation; Pros | 1973 |
Platelets, prostaglandins, red cells, sedimentation rates, serum and tissue proteins and non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Blood Platelets; Blood Proteins; Blood Sedimentation; Carrageenan | 1972 |
[Pharmacological studies on niflumic acid, with special reference to the comparison with fenametes. 1. Anti-inflammatory and analgesic actions].
Topics: Analgesics; Aniline Compounds; Animals; Anti-Inflammatory Agents; Arthritis; Capillary Permeability; | 1972 |
The aldehyde analog of indomethacin.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Foot; Half-Life; Indomethacin; Rat | 1973 |
Granulomatous hepatitis and prolonged fever of unknown origin: a study of 13 patients.
Topics: Adult; Ascites; Dexamethasone; Edema; Female; Fever; Fever of Unknown Origin; Granuloma; Hepatitis; | 1973 |
The role of sulfhydryl groups in three models of inflammatory disease.
Topics: Animals; Arthritis; Carrageenan; Croton Oil; Cyclophosphamide; Cysteine; Dexamethasone; Disulfides; | 1973 |
[Pharmacology of antiphlogistically active imidazoles].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Imidazoles; Indomethac | 1973 |
Sodium (o-((2,6-dichlorophenyl)-amino)-phenyl)-acetate (GP 45 840), a new non-steroidal anti-inflammatory agent.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Blood Sedimentation; Dose-Response Relationshi | 1973 |
Effect of steroidal and nonsteroidal anti-inflammatory compounds in a milkweed-sap-induced rat pedal edema.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Biological Assay; Chlorpromazine; Cyproheptadine; Dexame | 1973 |
Comparison of indomethacin and phenylbutazone in acute gout.
Topics: Acute Disease; Adult; Aged; Blood Sedimentation; Edema; Female; Gout; Humans; Indomethacin; Leukocyt | 1973 |
Evaluation of cryogenine on rat paw thermal oedema and rat isolated uterus.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Benzocaine; Bradykinin; Burns; Chlorpromazine; Dose-Re | 1973 |
Substituted anilides of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid.
Topics: Analgesics; Anilides; Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Edema; Femal | 1973 |
Bis(dimethylamino)-s-triazinyl antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Dimethylamines; Edema; Foot; Granuloma; Indomethacin; Kaolin; Let | 1973 |
The anti-edema activity of various naturally occurring cannabinoids.
Topics: Animals; Anti-Inflammatory Agents; Cannabis; Carrageenan; Central Nervous System; Depression, Chemic | 1973 |
[Anti-inflammatory effect of 2-phenyl-5-bromo-indandione (Uridion) with uricosuric acitivity].
Topics: Animals; Anti-Inflammatory Agents; Bromine; Drug Evaluation; Edema; Female; Indenes; Indomethacin; M | 1973 |
[Changes of mucopolysaccharase, protease and collagenolytic activities in rats with adjuvant arthritis and the effects of various anti-inflammatory drugs].
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Azathioprine; Barbiturates; Chloroquine; Collagen; Cyc | 1973 |
New analgesic-anti-inflammatory drugs. 1-Oxo-2-substituted isoindoline derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Drug Evaluation, Preclinical; Edema; Gra | 1973 |
Pharmacological study on a new analgesic-anti-inflammatory drug: alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionic acid of K 4277.
Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Behavi | 1973 |
[Pharmacology of butylmalonic acidmono-(1,2-diphenylhydrazide)-calcium (bumadizone-calcium)].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Arthritis, Rheumatoid; Blood Pr | 1973 |
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 1. On acute inflammation].
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Capillary Permeability; Edema; Electrolytes; Eryth | 1973 |
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 2. On subacute inflammation].
Topics: Acute Disease; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Body Weight; Ed | 1973 |
Antiinflammatory activity of the new mould metabolite 11-desacetoxy-wortmannin and of some of its derivatives.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Carrageenan; Coumarins; Dexamethasone; Edema; Freund's | 1974 |
Reduction of prostaglandin-phase in hind-paw inflammation and partial failure of indomethacin to exert anti-inflammatory effect in rats on essential fatty acid deficient diet.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Deficiency Diseases; Depression, Chemical; Diet; Ede | 1974 |
Quinuclidine chemistry. 2. Synthesis and antiinflammatory properties of 2-substituted benzhydryl-3-quinuclidinols.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Benzene Derivatives; Carrageenan; Edema; Granuloma | 1974 |
Effects of benzoquinolizine homologues on proliferative and exudative inflammation.
Topics: Adrenal Glands; Animals; Anti-Inflammatory Agents; Body Weight; Carrageenan; Catecholamines; Chlorpr | 1974 |
[Experimental results of combinations of nonsteroid anti-inflammatory agents in acute and chronic inflammation].
Topics: Acute Disease; Animals; Arthritis; Carrageenan; Chronic Disease; Drug Therapy, Combination; Edema; F | 1974 |
[Cytostatic antiphlogistics. II. Antimicrobial activity range and comparison in the Oedipus test].
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agen | 1970 |
dl- -(4-Cycloaklyl(cyclohexen-1-yl)alkanoic acids and derivatives as antiinflammatory and antiarthritic compounds.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Cyclohexanecarboxylic Acids; Cycloparaffins; Edema; Ex | 1972 |
Anti-inflammatory and other properties of 2,3-dihydrol-1-H-pyridino-(2,3- b) (1,4)-thiazine-2-one; ABBott-29590.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Dogs; Edema; Fever; Gastric Mucos | 1972 |
Effects of anti-inflammatory drugs on glutathione levels and liver succinic dehydrogenase activity in carrageenin edema and cotton pellet granuloma in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Glutathione; Gossypium; Granuloma; Hydrocorti | 1972 |
Effects of certain nonsteroid anti-inflammatory drugs, tolbutamide, and tetrahydroalstonine on blood glucose and carrageen in-induced pedal edema in rats.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Blood Glucose; Carrageenan; Chlorpromazine; Diabetes M | 1972 |
Anti-inflammatory activity of an essential oil from Zanthoxylum budrunga.
Topics: Animals; Anti-Inflammatory Agents; Betamethasone; Carrageenan; Edema; Female; Formaldehyde; Fruit; G | 1972 |
[Indomethacin in combination with anticoagulants in the treatment thrombophlebitis].
Topics: Aged; Anticoagulants; Drug Combinations; Edema; Female; Fever; Humans; Indomethacin; Male; Pain; Thr | 1972 |
[Anti-inflammatory effect of bimetopyrol. I. Suppressive effect on acute inflammation].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyproheptadine; Edema; Erythema; Fever; Flufenamic Acid; | 1972 |
[Anti-inflammatory effect of bimetopyrol. 3. Possible active substance and site of action].
Topics: Administration, Oral; Adrenalectomy; Animals; Anisoles; Anti-Inflammatory Agents; Binding Sites; Ede | 1972 |
Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 7. Pharmacological comparison with standard anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Benzyl Compounds; Edema; Female; Fever; Flufenamic Acid; Indometh | 1972 |
Release of lysosomal enzymes in experimental inflammations: effects of anti-inflammatory drugs.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Aspirin; Betamethasone; C | 1972 |
Studies on the antiphlogistic activity of cytostatics.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites; Carrageenan; Chloramphenicol; Cyclophosphamide; | 1972 |
The influence of anti-inflammatory and immunosuppressant drugs on Nystatin induced oedema.
Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis; Aspirin; Azathioprine; Ch | 1971 |
Anti-inflammatory and analgetic properties of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen).
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Edema; Fe | 1971 |
On the paw edema induced by subcutaneous injection of minute glass particles in the rat.
Topics: Administration, Oral; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Edema; Extremities; G | 1971 |
3-Benzoyldifluoromethanesulfonanilide, sodium salt (diflumidone sodium, MBR 4164-8): a new anti-inflammatory agent.
Topics: Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Benzoates; Car | 1971 |
[A comparative study on various antiphlogistics].
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Asbestos; Dextrans; Disease Models, Animal; Dr | 1971 |
Effects of antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in mice.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Colchicine; Edema; Female; Foot; Hindlimb; | 1971 |
A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Carrageenan; Edema; Indomethacin; Leukocyte | 1971 |
Applications of the mouse foot edema test in evaluation of anti-cholera drugs.
Topics: Animals; Anti-Infective Agents; Aspirin; Chloramphenicol; Cholera; Cycloheximide; Dactinomycin; Diur | 1971 |
5-Benzoyl-1-methylpyrrole-2-acetic acids as antiinflammatory agents.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Benzoates; Carrageenan; Edema; Granuloma; Indomethacin; | 1971 |
[Effect of indomethacin on postoperative edema and wound healing].
Topics: Child; Edema; Extremities; Humans; Indomethacin; Postoperative Complications; Wound Healing | 1971 |
[Effect of indomethacin on postoperative course in orthopedic procedures].
Topics: Adult; Aged; Body Temperature; Edema; Extremities; Female; Hematoma; Humans; Indomethacin; Inflammat | 1971 |
Studies in sickle-cell anemia. XXXI. Preliminary observations on the use of indomethacin in the treatment of thrombotic crises.
Topics: Adolescent; Anemia, Sickle Cell; Black or African American; Child; Edema; Female; Humans; Indomethac | 1966 |
Concerning the nature of intolerance to aspirin.
Topics: Aminopyrine; Antipyrine; Aspirin; Asthma; Chemoreceptor Cells; Drug Hypersensitivity; Edema; Histami | 1967 |
Diaryloxazole and diarylthiazolealkanoic acids: two novel series of non-steroidal anti-inflammatory agents.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Aspirin; Biological Assay; Carrageenan; Edema; Gastric | 1968 |
Investigation of the carrageenin-induced rat paw edema assay and correlation between anti-inflammatory activity and gastric hemorrhage production in the rat.
Topics: Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Croton Oil; Edem | 1970 |
A model for rat paw edema. II. Analyses on the effect of the antagonists.
Topics: Amino Alcohols; Animals; Anti-Inflammatory Agents; Bradykinin; Bromelains; Carbamates; Carrageenan; | 1970 |
[Treatment of hemorrhoid with Indacin suppository--including experiences in administration after anal operation].
Topics: Anus Diseases; Edema; Hemorrhage; Hemorrhoids; Humans; Indomethacin; Pain; Postoperative Care; Suppo | 1970 |
Interactions of anti-inflammatory drugs in carrageenan-induced foot edema of the rat.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Edema; Female; Foot Diseases; Hyd | 1970 |
[Analgesic and antiphlogistic action of amide and amine compounds. 1].
Topics: Amides; Amines; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Depression, Chemical; Ed | 1970 |
Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. I. Anti-inflammatory, analgesic and anti-pyretic activity.
Topics: Aminopyrine; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Aspirin; Bradykinin; Capill | 1970 |
Factors influencing the inhibitory action of anti-inflammatory drugs on carrageenin induced oedema.
Topics: Administration, Oral; Animals; Aspirin; Carrageenan; Edema; Female; Hindlimb; Humidity; Indomethacin | 1971 |
Anti-inflammatory and liver sulfhydryl content-altering effects of certain nonsteroids in the rat.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chlorpromazine; Cyproheptadine; | 1971 |
The local anti-inflammatory action of non-steroidal compounds on the paw oedema caused by kaolin in the rat.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Edema; Hindlimb; Indomethacin; Inflammation; Kaolin; | 1967 |
[Inhibitory action of indomethacin on generalized edema induced by dextran in rats].
Topics: Adrenal Glands; Animals; Catecholamines; Dextrans; Edema; Epinephrine; Indomethacin; Myocardium; Nor | 1968 |
Antiinflammatory activity of indomethacin and plasma corticosterone in rats.
Topics: Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Carrageenan; Corticosterone; Edema | 1968 |
Anti-inflammatory and related properties of 4-(p-biphenylyl)-3-hydroxybutyric acid.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Biphenyl Compounds; Blood Pressure; Bronchial | 1968 |
[Experiences with an indoleacetic acid derivate (Indomethacin) in the therapy of posttraumatic and postoperative edema].
Topics: Abscess; Cellulitis; Edema; Fractures, Bone; Humans; Indomethacin; Inflammation; Intestinal Neoplasm | 1968 |
[Activity of some derivatives of palmitoylethanolamide on carragenine-induced edema in the rat paw].
Topics: Amino Alcohols; Animals; Carrageenan; Edema; Indomethacin; Inflammation; Palmitic Acids; Rats; Stear | 1968 |
Local activity of anti-inflammatory and irritant agents on rat paw edema induced by carrageenin.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Croton Oil; Dexamethasone; Edema; Formaldehyde; Hydr | 1968 |
Action of antiinflammatory drugs on the lysozyme activity and "turbidity" of serum from rats with adjuvant arthritis or endocrine deficiency.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Blood Proteins; Edema; Freund' | 1969 |
Biphasic development of carrageenin edema in rats.
Topics: Animals; Aspirin; Body Temperature; Carrageenan; Edema; Foot; Hydrocortisone; Indomethacin; Male; Ph | 1969 |
Evans blue-carrageenan pleural effusion as a model for the assay of nonsteroidal antirheumatic drugs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carrageenan; Chloroquine; Coloring Agents; Ed | 1969 |
[On the inflammation inhibitory effect of (-)-alpha-bisabolol, an essential component of chamomilla oil].
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cycloparaffins; Edema; Female; Granuloma; Indomethac | 1969 |
[Pharmacological and toxicological testing of new anti-inflammatory agent azapropazon=3-dimethylamine-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine].
Topics: Abnormalities, Drug-Induced; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bloo | 1969 |
Synthesis and pharmacology of a new potential anti-inflammatory drug, 1-(3',4'-methylenedioxybenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid (ID-955).
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Blood Proteins; Capillary Permeability; Car | 1969 |
Reaction thresholds to pressure in edematous hindpaws of rats and responses to analgesic drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biological Assay; Cyclazocine; Dextropropoxyphene; Ed | 1965 |