indomethacin has been researched along with Edema-Proteinuria-Hypertension Gestosis in 24 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study characterises the reactivity of chorionic plate artery in pre-eclampsia to prostaglandin F2 alpha (PGF2 alpha), 5-hydroxytryptamine (5-HT), and potassium chloride (KCl) and examines the role of the vascular endothelium in these responses." | 7.69 | The role of the vascular endothelium in the contractile responses of human chorionic plate artery in pre-eclampsia to prostaglandin F2 alpha, 5-hydroxytryptamine, and potassium chloride. ( Aloamaka, CP; Ezimokhai, M; Mensah-Brown, EP; Morrison, J; Osman, NA, 1995) |
| "A condition similar to preeclampsia was induced by infusing pregnant rats with the nitric oxide synthase inhibitor N G -nitro- L -arginine methyl ester through subcutaneously implanted osmotic minipumps." | 5.30 | The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia. ( Buhimschi, I; Chwalisz, K; Garfield, RE; Liao, QP; Saade, GR; Zlatnik, MG, 1999) |
| "Provided that preeclampsia comprises enhanced vascular actions of thromboxane A2, the present results support the established use of Mg++ in the treatment of this condition and suggest that calcium antagonists are of potential benefit." | 5.28 | Effects of magnesium and isradipine on contractile activation induced by the thromboxane A2 analog U46619 in human uteroplacental arteries in term pregnancy. ( Andersson, KE; Forman, A; Skajaa, K; Svane, D, 1990) |
| "Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions." | 5.28 | Antagonism of antihypertensive drug therapy in pregnancy by indomethacin? ( Freedman, S; Hod, M; Ovadia, Y; Schoenfeld, A, 1989) |
| "This study characterises the reactivity of chorionic plate artery in pre-eclampsia to prostaglandin F2 alpha (PGF2 alpha), 5-hydroxytryptamine (5-HT), and potassium chloride (KCl) and examines the role of the vascular endothelium in these responses." | 3.69 | The role of the vascular endothelium in the contractile responses of human chorionic plate artery in pre-eclampsia to prostaglandin F2 alpha, 5-hydroxytryptamine, and potassium chloride. ( Aloamaka, CP; Ezimokhai, M; Mensah-Brown, EP; Morrison, J; Osman, NA, 1995) |
| "We hypothesized that in preeclampsia (PE), contribution of endothelium-derived hyperpolarizing factor (EDHF) and the mechanism/s of its action differ from that in normal pregnancy (NP)." | 1.35 | Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites. ( Hultenby, K; Kublickas, M; Kublickiene, K; Luksha, L; Luksha, N; Nisell, H, 2008) |
| "Chorioamnionitis was positively correlated with the risk, but did not reach statistical significance." | 1.33 | Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia. ( Itakura, A; Matsuzawa, K; Mizutani, S; Murata, Y; Okumura, A; Wakai, K, 2005) |
| "Tissues from women with preeclampsia demonstrated the highest contractile response to U46619." | 1.31 | Inhibition of cyclooxygenase but not nitric oxide synthase influences effects on the human omental artery of the thromboxane A2 mimetic U46619 and 17beta-estradiol. ( Belfort, MA; Garfield, RE; Saade, GR; Vedernikov, YP, 2001) |
| "In women with preeclampsia, the function of the endothelium is compromised, and it is suggested that reduced nitric oxide synthesis may contribute to the elevation of blood pressure and activation of coagulation pathways." | 1.30 | Flow-mediated vasodilatation is enhanced in normal pregnancy but reduced in preeclampsia. ( Cockell, AP; Poston, L, 1997) |
| "A condition similar to preeclampsia was induced by infusing pregnant rats with the nitric oxide synthase inhibitor N G -nitro- L -arginine methyl ester through subcutaneously implanted osmotic minipumps." | 1.30 | The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia. ( Buhimschi, I; Chwalisz, K; Garfield, RE; Liao, QP; Saade, GR; Zlatnik, MG, 1999) |
| "The vessels from women with preeclampsia showed markedly reduced relaxation to bradykinin (p < 0." | 1.30 | Mechanisms of endothelium-dependent relaxation in myometrial resistance vessels and their alteration in preeclampsia. ( Ashworth, JR; Baker, PN; Johnson, IR; Warren, AY, 1999) |
| "Provided that preeclampsia comprises enhanced vascular actions of thromboxane A2, the present results support the established use of Mg++ in the treatment of this condition and suggest that calcium antagonists are of potential benefit." | 1.28 | Effects of magnesium and isradipine on contractile activation induced by the thromboxane A2 analog U46619 in human uteroplacental arteries in term pregnancy. ( Andersson, KE; Forman, A; Skajaa, K; Svane, D, 1990) |
| "Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions." | 1.28 | Antagonism of antihypertensive drug therapy in pregnancy by indomethacin? ( Freedman, S; Hod, M; Ovadia, Y; Schoenfeld, A, 1989) |
| "The glomerular lesions of preeclampsia consist of swelling of endothelial cells, interposition of mesangial cells and matrix between the endothelial cells and the glomerular basement membrane, and organization of subendothelial deposits of incompletely characterized material." | 1.27 | Accumulation of several basement membrane proteins in glomeruli of patients with preeclampsia and other hypertensive syndromes of pregnancy. Possible role of renal prostaglandins and fibronectin. ( Bariety, J; Foidart, JB; Foidart, JM; Lambotte, R; Lapiere, CM; Mahieu, PR; Nochy, D; Nusgens, B, 1983) |
| "Preeclampsia is characterized by increased vasoconstriction frequently associated with increased platelet aggregation, reduced uteroplacental blood flow, and premature delivery." | 1.27 | Preeclampsia: an imbalance in placental prostacyclin and thromboxane production. ( Walsh, SW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (29.17) | 18.7374 |
| 1990's | 11 (45.83) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayward, CE | 1 |
| Cowley, EJ | 1 |
| Mills, TA | 1 |
| Sibley, CP | 1 |
| Wareing, M | 1 |
| Steinert, JR | 1 |
| Poston, L | 3 |
| Mann, GE | 1 |
| Jacob, R | 1 |
| Murata, Y | 1 |
| Itakura, A | 1 |
| Matsuzawa, K | 1 |
| Okumura, A | 1 |
| Wakai, K | 1 |
| Mizutani, S | 1 |
| Luksha, L | 1 |
| Nisell, H | 1 |
| Luksha, N | 1 |
| Kublickas, M | 1 |
| Hultenby, K | 1 |
| Kublickiene, K | 1 |
| Saeed, SA | 1 |
| Mitchell, MD | 1 |
| Foidart, JM | 1 |
| Nochy, D | 1 |
| Nusgens, B | 1 |
| Foidart, JB | 1 |
| Mahieu, PR | 1 |
| Lapiere, CM | 1 |
| Lambotte, R | 1 |
| Bariety, J | 1 |
| O'Brien, WF | 1 |
| Cefalo, RC | 1 |
| Lewis, PE | 1 |
| Fletcher, JR | 1 |
| Ramwell, PW | 1 |
| Gallery, ED | 1 |
| Rowe, J | 1 |
| Campbell, S | 1 |
| Hawkins, T | 1 |
| McCarthy, AL | 1 |
| Woolfson, RG | 1 |
| Raju, SK | 1 |
| Ezimokhai, M | 1 |
| Aloamaka, CP | 1 |
| Osman, NA | 1 |
| Mensah-Brown, EP | 1 |
| Morrison, J | 1 |
| González, C | 1 |
| Cruz, MA | 1 |
| Gallardo, V | 1 |
| Lagos, M | 1 |
| Varela, J | 1 |
| Albornoz, J | 1 |
| Schulz, C | 1 |
| Cockell, AP | 1 |
| Matthiesen, L | 1 |
| Berg, G | 1 |
| Ernerudh, J | 1 |
| Håkansson, L | 1 |
| Zlatnik, MG | 1 |
| Buhimschi, I | 1 |
| Chwalisz, K | 1 |
| Liao, QP | 1 |
| Saade, GR | 2 |
| Garfield, RE | 2 |
| Ashworth, JR | 1 |
| Baker, PN | 1 |
| Warren, AY | 1 |
| Johnson, IR | 1 |
| Vedernikov, YP | 1 |
| Belfort, MA | 1 |
| Sheu, JR | 1 |
| Hsiao, G | 1 |
| Shen, MY | 1 |
| Lin, WY | 1 |
| Tzeng, CR | 1 |
| Kaulhausen, H | 1 |
| Oney, T | 1 |
| King, RG | 1 |
| Gude, NM | 1 |
| Krishna, BR | 1 |
| Chen, S | 1 |
| Brennecke, SP | 1 |
| Boura, AL | 1 |
| Rook, TJ | 1 |
| Mousavy, SM | 1 |
| Skajaa, K | 1 |
| Svane, D | 1 |
| Andersson, KE | 1 |
| Forman, A | 1 |
| Schoenfeld, A | 1 |
| Freedman, S | 1 |
| Hod, M | 1 |
| Ovadia, Y | 1 |
| Jarabak, J | 1 |
| Walsh, SW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of High Altitude on 5' Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation and Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulation[NCT02391519] | 84 participants (Anticipated) | Observational | 2016-01-31 | Recruiting | |||
| Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial[NCT03824119] | Phase 4 | 200 participants (Anticipated) | Interventional | 2018-12-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for indomethacin and Edema-Proteinuria-Hypertension Gestosis
| Article | Year |
|---|---|
[New aspects of the pathophysiology of gestosis/pre-eclampsia (author's transl)].
Topics: Angiotensin II; Blood Pressure; Bradykinin; Dopamine; Eclampsia; Female; Humans; Indomethacin; Kalli | 1979 |
Human placental acetylcholine.
Topics: Acetylcholine; Amino Acids; Atropine; Female; Humans; Indomethacin; Placenta; Pre-Eclampsia; Pregnan | 1991 |
22 other studies available for indomethacin and Edema-Proteinuria-Hypertension Gestosis
| Article | Year |
|---|---|
Maternal obesity impairs specific regulatory pathways in human myometrial arteries.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteries; Biopsy; Body Mass Index; Body Weight; Endothelium | 2014 |
Abnormalities in intracellular Ca2+ regulation in fetal vascular smooth muscle in pre-eclampsia: enhanced sensitivity to arachidonic acid.
Topics: Arachidonic Acid; Calcium; Cyclooxygenase Inhibitors; Female; Fetus; Humans; Indomethacin; Lipoxygen | 2003 |
Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia.
Topics: Apgar Score; Case-Control Studies; Causality; Cerebral Palsy; Chorioamnionitis; Comorbidity; Female; | 2005 |
Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites.
Topics: Adolescent; Adult; Arachidonic Acid; Arteries; Biological Factors; Biopsy; Bradykinin; Cardiovascula | 2008 |
Lipoxygenase activity in human uterine and intrauterine tissues: new prospects for control of prostacyclin production in pre-eclampsia.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arach | 1983 |
Accumulation of several basement membrane proteins in glomeruli of patients with preeclampsia and other hypertensive syndromes of pregnancy. Possible role of renal prostaglandins and fibronectin.
Topics: Basement Membrane; Collagen; Female; Fibrin; Fibronectins; Glycoproteins; Humans; Hypertension; Indo | 1983 |
The role of prostaglandins in endotoxemia and comparisons in response in the nonpregnant, maternal, and fetal models. II. Alterations in prostaglandin physiology in the nonpregnant, pregnant, and fetal experimental animal.
Topics: Animals; Endotoxins; Escherichia coli; Female; Fetus; Indomethacin; Pre-Eclampsia; Pregnancy; Prosta | 1981 |
Secretion of prostaglandins and endothelin-1 by decidual endothelial cells from normal and preeclamptic pregnancies: comparison with human umbilical vein endothelial cells.
Topics: Cells, Cultured; Cesarean Section; Decidua; Endothelins; Endothelium, Vascular; Epoprostenol; Female | 1995 |
Abnormal endothelial cell function of resistance arteries from women with preeclampsia.
Topics: Acetylcholine; Adult; Amino Acid Oxidoreductases; Arteries; Endothelium, Vascular; Female; Humans; I | 1993 |
The role of the vascular endothelium in the contractile responses of human chorionic plate artery in pre-eclampsia to prostaglandin F2 alpha, 5-hydroxytryptamine, and potassium chloride.
Topics: Arteries; Chorion; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Human | 1995 |
Nitric oxide and prostaglandin systems inhibition on the isolated perfused human placenta from normal and preeclamptic pregnancies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Arginine; Dose-Response Relationship, Drug; Fema | 1995 |
Flow-mediated vasodilatation is enhanced in normal pregnancy but reduced in preeclampsia.
Topics: Adult; Arteries; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Humans; Indomethacin; NG-Nitr | 1997 |
Lymphocyte subsets and mitogen stimulation of blood lymphocytes in preeclampsia.
Topics: Adult; Cells, Cultured; Cimetidine; Dexamethasone; Female; Flow Cytometry; Humans; Indomethacin; Int | 1999 |
The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Epopr | 1999 |
Mechanisms of endothelium-dependent relaxation in myometrial resistance vessels and their alteration in preeclampsia.
Topics: Adult; Bradykinin; Cardiovascular Agents; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; | 1999 |
Inhibition of cyclooxygenase but not nitric oxide synthase influences effects on the human omental artery of the thromboxane A2 mimetic U46619 and 17beta-estradiol.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Arteries; Cyclooxygenase | 2001 |
The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways.
Topics: Adult; Alprostadil; Calcium Signaling; Cyclic AMP; Disease Susceptibility; Female; Humans; Hydrogen- | 2002 |
Indomethacin induces hypertensive crisis in preeclampsia irrespective of prior antihypertensive drug therapy.
Topics: Antihypertensive Agents; Drug Antagonism; Female; Humans; Hypertension; Indomethacin; Pre-Eclampsia; | 1991 |
Effects of magnesium and isradipine on contractile activation induced by the thromboxane A2 analog U46619 in human uteroplacental arteries in term pregnancy.
Topics: Antihypertensive Agents; Arteries; Calcium Channel Blockers; Digoxin; Female; Humans; Indomethacin; | 1990 |
Antagonism of antihypertensive drug therapy in pregnancy by indomethacin?
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Indomethacin; Obstetric Labor, Prema | 1989 |
Inhibition of the human placental NAD- and NADP-linked 15-hydroxyprostaglandin dehydrogenases by nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Hydroxyprostaglandin Dehydrogenases; Indome | 1988 |
Preeclampsia: an imbalance in placental prostacyclin and thromboxane production.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Arachidonic Acids; Culture Media; Epoprosteno | 1985 |