indomethacin has been researched along with Eczema, Atopic in 16 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is concluded that patients with atopic eczema often exhibit altered releasability patterns to a variety of stimuli." | 2.37 | Altered releasability of vasoactive mediator secreting cells in atopic eczema. ( Dorsch, W; Ring, J, 1985) |
| "Atopic dermatitis is a chronic inflammatory disease characterized by severe pruritus, and cutaneous barrier disruption by scratching contributes to further aggravation of the condition." | 1.34 | Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice. ( Arai, I; Futaki, N; Hashimoto, Y; Honma, Y; Nakaike, S; Sakurai, T; Sugimoto, M, 2007) |
| "Pretreatment of arachidonic acid increased the skin prostaglandins (prostaglandin D2, prostaglandin E2, prostaglandin F2alpha and 6-keto-prostaglandin F1alpha) contents, but indomethacin decreased the prostaglandin D2 and prostaglandin E2 contents." | 1.32 | Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. ( Arai, I; Futaki, N; Hashimoto, Y; Inoue, T; Nakaike, S; Sugimoto, M; Takahashi, N; Takano, N, 2004) |
| "However, decreased NK cell activity in atopic eczema was positively correlated with decreased numbers of Fc gamma + lymphocytes (P = 0." | 1.27 | Decreased natural killer cell activity in atopic eczema. ( Brostoff, J; Hall, TJ; Rycroft, R, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanda, N | 1 |
| Tani, K | 1 |
| Enomoto, U | 1 |
| Nakai, K | 1 |
| Watanabe, S | 1 |
| Arai, I | 2 |
| Takano, N | 1 |
| Hashimoto, Y | 2 |
| Futaki, N | 2 |
| Sugimoto, M | 2 |
| Takahashi, N | 1 |
| Inoue, T | 1 |
| Nakaike, S | 2 |
| Honma, Y | 1 |
| Sakurai, T | 1 |
| DeShazo, RD | 1 |
| Levinson, AI | 1 |
| Dvorak, HF | 1 |
| Mason, UG | 1 |
| Kirkpatrick, CH | 1 |
| Patterson, R | 1 |
| Harris, KE | 1 |
| Burdeĭnyĭ, AP | 1 |
| Ostlere, LS | 1 |
| Mallett, RB | 1 |
| Kaminski, A | 1 |
| Kaminski, ER | 1 |
| Pereira, RS | 1 |
| Holden, CA | 1 |
| Chan, SC | 1 |
| Kim, JW | 1 |
| Henderson, WR | 1 |
| Hanifin, JM | 1 |
| Punnonen, J | 1 |
| Punnonen, K | 1 |
| Jansén, CT | 1 |
| Kalimo, K | 1 |
| Byron, KA | 1 |
| Liberatos, S | 1 |
| Varigos, GA | 1 |
| Wootton, AM | 1 |
| Voznesenskaia, NI | 1 |
| Ziabkina, AG | 1 |
| Markov, KhM | 1 |
| Jakob, T | 1 |
| Huspith, BN | 1 |
| Latchman, YE | 1 |
| Rycroft, R | 2 |
| Brostoff, J | 2 |
| Ring, J | 1 |
| Dorsch, W | 1 |
| Collins-Williams, C | 1 |
| Hall, TJ | 1 |
1 review available for indomethacin and Eczema, Atopic
| Article | Year |
|---|---|
Altered releasability of vasoactive mediator secreting cells in atopic eczema.
Topics: Animals; Arachidonic Acids; Basophils; Blood Platelets; Complement Activation; Cyclic AMP; Cyclic GM | 1985 |
1 trial available for indomethacin and Eczema, Atopic
| Article | Year |
|---|---|
[Double-blind trial of the therapeutic efficacy of voltaren and indomethacin in Bechterew's disease].
Topics: Adult; Clinical Trials as Topic; Dermatitis, Atopic; Diclofenac; Dizziness; Double-Blind Method; Fem | 1981 |
14 other studies available for indomethacin and Eczema, Atopic
| Article | Year |
|---|---|
The skin fungus-induced Th1- and Th2-related cytokine, chemokine and prostaglandin E2 production in peripheral blood mononuclear cells from patients with atopic dermatitis and psoriasis vulgaris.
Topics: Adult; Antigens, Fungal; Candida albicans; Case-Control Studies; Chemokine CCL22; Chemokine CXCL10; | 2002 |
Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis.
Topics: 6-Ketoprostaglandin F1 alpha; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachid | 2004 |
Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2007 |
The late phase skin reaction: paradigm or epiphenomena?
Topics: Adrenal Cortex Hormones; Animals; Arthus Reaction; Chemotaxis, Leukocyte; Dermatitis, Atopic; Diseas | 1983 |
Modulation of immunologic responses in nontuberculous mycobacterial infections with indomethacin.
Topics: Dermatitis, Atopic; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Indomethacin; Lymphocyte | 1984 |
An inhibitor of the lipoxygenase and cyclooxygenase pathways of arachidonic acid, 5, 8, 11, 14-eicosatetraynoic acid, inhibits immunoglobulin E mediated antigen induced monkey asthma and skin reactions.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonate Lipoxygenases; Asthma; Cyclooxygenase Inhibit | 1980 |
gamma-interferon production in atopic dermatitis shows differential modification by phosphodiesterase and prostaglandin inhibition.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Bucladesine; Cells, Cultured; Cyclooxygenase Inhibitors; | 1995 |
Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cells, Cultured; Dermatitis, Atopic; Dinoprostone; Humans; In V | 1993 |
Interferon (IFN)-alpha, IFN-gamma, interleukin (IL)-2, and arachidonic acid metabolites modulate IL-4-induced IgE synthesis similarly in healthy persons and in atopic dermatitis patients.
Topics: Adult; Arachidonic Acids; Cells, Cultured; Cytokines; Dermatitis, Atopic; Female; Humans; Immunoglob | 1993 |
Interferon-gamma production in atopic dermatitis: a role for prostaglandins?
Topics: Cells, Cultured; Dermatitis, Atopic; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Humans; Immuno | 1992 |
[Use of indomethacin in patients with severe course of atopic dermatitis and dermo-respiratory syndrome].
Topics: Child; Child, Preschool; Dermatitis, Atopic; Humans; Indomethacin; Infant; Neurodermatitis; Respirat | 1990 |
Depressed lymphocyte transformation and the role of prostaglandins in atopic dermatitis.
Topics: Adolescent; Adult; Antigen-Antibody Complex; Cells, Cultured; Child; Dermatitis, Atopic; Dinoproston | 1990 |
The role of pharmacologic agents in the prevention or treatment of allergic food disorders.
Topics: Administration, Oral; Adult; Aspirin; Beclomethasone; Child; Cromolyn Sodium; Dermatitis, Atopic; Fo | 1986 |
Decreased natural killer cell activity in atopic eczema.
Topics: Adult; Dermatitis, Atopic; Dinoprostone; Female; Humans; Indomethacin; Killer Cells, Natural; Leukoc | 1985 |