indomethacin has been researched along with EHS Tumor in 42 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin, a non-steroidal anti-inflammatory drug which is also a calcium antagonist and an inhibitor of prostaglandin synthesis was observed to have a chemotherapeutic effect in a mouse fibrosarcoma." | 7.67 | Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma. ( Shenoy, MA; Singh, BB, 1989) |
| "Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice." | 5.28 | Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991) |
| "Indomethacin, a non-steroidal anti-inflammatory drug which is also a calcium antagonist and an inhibitor of prostaglandin synthesis was observed to have a chemotherapeutic effect in a mouse fibrosarcoma." | 3.67 | Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma. ( Shenoy, MA; Singh, BB, 1989) |
| "Indomethacin, an inhibitor of prostaglandin (PG) synthesis, was investigated for its ability to increase radioresponse of two fibrosarcomas, FSA and NFSA, in C3Hf/Kam mice." | 3.67 | Increase in radioresponse of murine tumors by treatment with indomethacin. ( Barkley, T; Furuta, Y; Hall, E; Hunter, N; Milas, L, 1988) |
| "The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth." | 3.66 | Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat. ( Peterson, HI, 1983) |
| "Indomethacin was continuously administered in the drinking water of inbred C3H mice given grafts of syngeneic 3-methylcholanthrene-induced fibrosarcomas." | 3.66 | Tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice. ( Lynch, NR; Salomon, JC, 1979) |
| "The growth of a 3-methylcholanthrene-induced fibrosarcoma of C3H mice was inhibited by aspirin and indomethacin." | 3.66 | Mechanism of inhibition of tumour growth by aspirin and indomethacin. ( Astoin, M; Castes, M; Lynch, NR; Salomon, JC, 1978) |
| " In the present study, [3H]arachidonate-labeled phospholipids of HSDM1C1 cells, a cell line derived from a mouse fibrosarcoma, were examined to determine the donor of the arachidonic acid released upon bradykinin stimulation of the synthesis of PGE2." | 3.66 | Bradykinin-stimulated release of [3H]arachidonic acid from phospholipids of HSDM1C1 cells: comparison of diacyl phospholipids and plasmalogens as sources of prostaglandin precursors. ( Blank, ML; Schremmer, JM; Wykle, RL, 1979) |
| "Indomethacin was provided in the drinking water to explore interactions between host and tumor-derived prostaglandins and proinflammatory cytokines for tumor growth." | 1.31 | Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia. ( Axelsson, H; Cahlin, C; Körner, A; Lundholm, K; Svanberg, E; Wang, W, 2000) |
| "Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice." | 1.28 | Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991) |
| "Indomethacin treatment prolonged survival and 40% of these tumour-bearers were 'complete responders'." | 1.28 | The effect of indomethacin on food and water intake, motor activity and survival in tumour-bearing rats. ( Gelin, J; Lundholm, K; Sandström, R, 1990) |
| "Indomethacin has little effect on the development of this suppressor cell activity." | 1.27 | Modification by biological products of the generation of suppressor cells in culture. ( Ehrke, MJ; Leung, KH; Mihich, E, 1983) |
| "Indomethacin treatment showed Prostaglandin E2 was not a direct in vitro factor in Ia antigen-mediated reduction of splenic M phi MLR stimulatory activity." | 1.27 | Variations in macrophage antigen phenotype: a correlation between Ia antigen reduction and immune dysfunction during tumor growth. ( Elgert, KD; Garner, RE; Malick, AP, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (64.29) | 18.7374 |
| 1990's | 13 (30.95) | 18.2507 |
| 2000's | 2 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, W | 2 |
| Andersson, M | 1 |
| Lõnnroth, C | 2 |
| Svanberg, E | 2 |
| Lundholm, K | 4 |
| Sundbeck, A | 1 |
| Karlsson, L | 1 |
| Lilja, J | 1 |
| Peterson, HI | 2 |
| Leung, KH | 2 |
| Ehrke, MJ | 2 |
| Mihich, E | 2 |
| Fulton, AM | 1 |
| Levy, JG | 1 |
| Garrigues, HJ | 1 |
| Romero, P | 1 |
| Hellström, I | 1 |
| Hellström, KE | 1 |
| Cochran, FR | 1 |
| Baxter, CS | 1 |
| Rojo, JM | 1 |
| Barasoain, I | 1 |
| Portolés, A | 1 |
| DeGowin, RL | 1 |
| Gibson, DP | 1 |
| Knapp, SA | 1 |
| Wathen, LM | 1 |
| Evans, R | 1 |
| Eidlen, LG | 1 |
| Hanson, WR | 1 |
| Zhen, W | 1 |
| Geng, L | 1 |
| Hunter, N | 4 |
| Milas, L | 7 |
| Cincotta, L | 1 |
| Foley, JW | 1 |
| MacEachern, T | 1 |
| Lampros, E | 1 |
| Cincotta, AH | 1 |
| Besa, PC | 1 |
| Hunter, NR | 2 |
| Grégoire, V | 1 |
| Brock, WA | 1 |
| Hittelman, WN | 1 |
| Plunkett, W | 1 |
| Włodarski, K | 1 |
| Luczak, M | 1 |
| Galus, R | 1 |
| Włodarski, P | 1 |
| Cahlin, C | 1 |
| Körner, A | 1 |
| Axelsson, H | 1 |
| Lynch, NR | 2 |
| Salomon, JC | 2 |
| Castes, M | 1 |
| Astoin, M | 1 |
| Strausser, HR | 3 |
| Rosenstein, MM | 1 |
| Schremmer, JM | 1 |
| Blank, ML | 1 |
| Wykle, RL | 1 |
| Brekke, OL | 1 |
| Espevik, T | 1 |
| Bardal, T | 1 |
| Bjerve, KS | 1 |
| Gelin, J | 3 |
| Andersson, C | 1 |
| Young, MR | 1 |
| Okada, F | 1 |
| Tada, M | 1 |
| Hosokawa, M | 1 |
| Kobayashi, H | 1 |
| Ito, H | 1 |
| Nakayama, T | 1 |
| Sandström, R | 1 |
| Wlodarski, KH | 1 |
| Zajícová, A | 1 |
| Holán, V | 1 |
| Furuta, Y | 3 |
| Nishiguchi, I | 1 |
| Runkel, S | 1 |
| Shenoy, MA | 1 |
| Singh, BB | 1 |
| Kim, B | 1 |
| Warnaka, P | 1 |
| Hall, ER | 1 |
| Sanduja, S | 1 |
| Barkley, T | 2 |
| Nakata, K | 1 |
| Kashimoto, S | 1 |
| Yoshida, H | 1 |
| Oku, T | 1 |
| Nakamura, S | 1 |
| Moldawer, LL | 1 |
| deMan, P | 1 |
| Svanborg-Eden, C | 1 |
| Lowry, SF | 1 |
| Lundholm, KG | 1 |
| Hall, E | 1 |
| Garner, RE | 1 |
| Malick, AP | 1 |
| Elgert, KD | 1 |
| Ohshika, Y | 1 |
| Umesaki, N | 1 |
| Kawabata, M | 1 |
| Sako, H | 1 |
| Sugawa, T | 1 |
| Nanjo, M | 1 |
| Yoshie, O | 1 |
| Aso, H | 1 |
| Ebina, T | 1 |
| Ishida, N | 1 |
| Jones, GR | 1 |
| Thatcher, R | 1 |
| Tashjian, AH | 1 |
| Voelkel, EF | 1 |
| Goldhaber, P | 1 |
| Levine, L | 1 |
| Humes, JL | 2 |
| Cupo, JJ | 1 |
1 review available for indomethacin and EHS Tumor
| Article | Year |
|---|---|
Immunosuppression as a homeostatic mechanism in disease and aging.
Topics: Aging; Animals; B-Lymphocytes; Homeostasis; Immunity; Immunosuppression Therapy; Indomethacin; Macro | 1979 |
41 other studies available for indomethacin and EHS Tumor
| Article | Year |
|---|---|
Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexia.
Topics: Animals; Base Sequence; Body Weight; Cachexia; Dinoprostone; Disease Models, Animal; DNA Primers; DN | 2005 |
Inhibition of tumour vascularization by tranexamic acid. Experimental studies on possible mechanisms.
Topics: Angiography; Animals; Cyclohexanecarboxylic Acids; Indomethacin; Microscopy, Electron; Muscles; Neop | 1981 |
Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
Topics: Animals; Aspirin; Diclofenac; Fibrosarcoma; Indomethacin; Liver Neoplasms, Experimental; Neoplasm Tr | 1983 |
Modification by biological products of the generation of suppressor cells in culture.
Topics: Animals; Antigens; Cells, Cultured; Culture Media; Dinoprostone; Female; Indomethacin; Mast-Cell Sar | 1983 |
The possible role of prostaglandins in mediating immune suppression by nonspecific T suppressor cells.
Topics: Animals; Antibody Formation; Cell Adhesion; Female; Immune Tolerance; Indomethacin; Mice; Prostaglan | 1980 |
Adherent cells (macrophages?) in tumor-bearing mice suppress MLC responses.
Topics: Animals; Cell Adhesion; Fibrosarcoma; Immunosuppression Therapy; Indomethacin; Lymphocyte Culture Te | 1981 |
Carrageenan-induced suppression of T-lymphocyte proliferation in the rat: abrogation of suppressor factor production by the prostaglandin synthesis inhibitors, indomethacin and ETYA.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Carrageenan; Cell Division; Cells, Cultured; Fatty Acids, | 1984 |
Variable effects of indomethacin and four related compounds on lymphocyte blastogenesis and cell-mediated cytotoxicity.
Topics: Animals; B-Lymphocytes; Concanavalin A; Cytotoxicity, Immunologic; Esters; In Vitro Techniques; Indo | 1981 |
Modulation of the development of cell-mediated immunity: possible role of the products of the cyclo-oxygenase and the lipoxygenase pathways of arachidonic acid metabolism.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Female; Immunity, Cellular; | 1982 |
Tumor-induced suppression of marrow stromal colonies.
Topics: Animals; Bone Marrow Cells; Carcinoma, Ehrlich Tumor; Cells, Cultured; Colony-Forming Units Assay; C | 1981 |
The role of the inflammatory response during tumor growth.
Topics: Animals; Cell Division; Hydrocortisone; Indomethacin; Inflammation; Macrophages; Mice; Neutrophils; | 1982 |
The prostaglandin E1 analog, misoprostol, a normal tissue protector, does not protect four murine tumors in vivo from radiation injury.
Topics: Animals; Cell Division; Dose-Response Relationship, Radiation; Female; Indomethacin; Lung Neoplasms; | 1995 |
Novel photodynamic effects of a benzophenothiazine on two different murine sarcomas.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry, Physical; Disease Mode | 1994 |
Improvement in radiotherapy for a murine sarcoma by indomethacin plus WR-2721.
Topics: Amifostine; Animals; Contracture; Drug Therapy, Combination; Indomethacin; Male; Mice; Mice, Inbred | 1993 |
Improvement in the therapeutic ratio of radiotherapy for a murine sarcoma by indomethacin plus fludarabine.
Topics: Animals; Antineoplastic Agents; Indomethacin; Male; Mice; Mice, Inbred C3H; Prostaglandin Antagonist | 1996 |
Local hypertrophic/hyperplastic changes of keratinizing squamous epithelium of pinna induced by concanavalin A and other immunomodulators in mice.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Transplantatio | 1999 |
Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Body Weight; Cachexia; Cell Division; | 2000 |
Tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice.
Topics: Animals; BCG Vaccine; Female; Fibrosarcoma; Immunotherapy; Indomethacin; Male; Mice; Mice, Inbred C3 | 1979 |
Mechanism of inhibition of tumour growth by aspirin and indomethacin.
Topics: Animals; Antibodies, Neoplasm; Aspirin; Female; Fibrosarcoma; Hemolytic Plaque Technique; Immunosupp | 1978 |
Bradykinin-stimulated release of [3H]arachidonic acid from phospholipids of HSDM1C1 cells: comparison of diacyl phospholipids and plasmalogens as sources of prostaglandin precursors.
Topics: Animals; Arachidonic Acids; Bradykinin; Cell Line; Fibrosarcoma; Indomethacin; Mice; Phospholipids; | 1979 |
Effects of n-3 and n-6 fatty acids on tumor necrosis factor cytotoxicity in WEHI fibrosarcoma cells.
Topics: Animals; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Survival; Clone Cells; Dexamethaso | 1992 |
Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia.
Topics: Animals; Body Weight; Cachexia; Cyclosporins; Eating; Female; Indomethacin; Interleukin-1; Interleuk | 1991 |
Association of increased tumor cell responsiveness to prostaglandin E2 with more aggressive tumor behavior.
Topics: Animals; Cell Line; Cell Movement; Clone Cells; Dinoprostone; Fibrosarcoma; Genetic Variation; Indom | 1991 |
Improvement in therapeutic ratio of radiotherapy for a murine sarcoma by indomethacin plus misonidazole.
Topics: Animals; Drug Therapy, Combination; Female; Indomethacin; Mice; Mice, Inbred C3H; Misonidazole; Radi | 1991 |
The effect of indomethacin on food and water intake, motor activity and survival in tumour-bearing rats.
Topics: Animals; Drinking; Eating; Indomethacin; Motor Activity; Rats; Rats, Inbred Strains; Sarcoma, Experi | 1990 |
Indomethacin influences Moloney's sarcoma and associated periosteal osteogenesis in the mouse.
Topics: Animals; Indomethacin; Male; Mice; Osteogenesis; Periosteum; Sarcoma, Experimental | 1990 |
Active suppression of the proliferative response to interleukin-2 in tumour-bearing mice.
Topics: Animals; Cell Division; Cells, Cultured; Culture Media; Indomethacin; Interleukin-1; Interleukin-2; | 1990 |
Dependence of indomethacin-induced potentiation of murine tumor radioresponse on tumor host immunocompetence.
Topics: Animals; Cell Division; Fibrosarcoma; Indomethacin; Mice; Mice, Inbred C3H; Mice, Nude; Radiation-Se | 1990 |
Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma.
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Fibrosarcoma; Hyperthermia, Induced; Indo | 1989 |
Indomethacin-enhanced immunotherapy of pulmonary metastases using IL-2 and IFN-alpha.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Cell Division; Female; Immunotherapy; Indomethacin | 1989 |
Prostaglandin production by murine tumors as a predictor for therapeutic response to indomethacin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Biomarkers, Tumor; Carbo | 1988 |
Augmented antitumor effect of recombinant human interleukin-1 alpha by indomethacin.
Topics: Adenocarcinoma; Animals; Cell Division; Drug Administration Schedule; Drug Synergism; Indomethacin; | 1988 |
Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma.
Topics: Animals; Indomethacin; Interleukin-6; Interleukins; Mice; Sarcoma, Experimental; Serum Amyloid P-Com | 1988 |
Increase in radioresponse of murine tumors by treatment with indomethacin.
Topics: Animals; Cell Survival; Combined Modality Therapy; Female; Fibrosarcoma; Indomethacin; Male; Mice; M | 1988 |
Variations in macrophage antigen phenotype: a correlation between Ia antigen reduction and immune dysfunction during tumor growth.
Topics: Animals; Antigen-Presenting Cells; Antigens, Surface; Cells, Cultured; Histocompatibility Antigens C | 1986 |
[Evaluation of indomethacin in non-specific immunotherapy].
Topics: Animals; Biological Products; Drug Synergism; Female; Humans; Indomethacin; Interleukin-1; Macrophag | 1986 |
[Antitumor effect of human recombinant interferon-alpha A/D in mice(I): Comparison between systemic and lesional treatment of meth-A sarcoma in BALB/c mice].
Topics: Animals; Cyclophosphamide; Drug Therapy, Combination; Female; Indomethacin; Injections; Interferon T | 1985 |
A comparison of the effects of the optical isomers of isoproterenol on energy metabolism in a mouse sarcoma.
Topics: Adenine Nucleotides; Animals; Energy Metabolism; Free Radicals; Indomethacin; Isoproterenol; Mice; O | 1985 |
Prostaglandins, calcium metabolism and cancer.
Topics: Animals; Aspirin; Bone and Bones; Bone Resorption; Calcium; Calcium Radioisotopes; Cells, Cultured; | 1974 |
Prostaglandins and cyclic nucleotides in Moloney sarcoma tumors.
Topics: Animals; Arachidonic Acids; Bucladesine; Chromatography, Gel; Chromatography, Thin Layer; Cyclic AMP | 1974 |
Effects of indomethacin on Moloney sarcoma virus-induced tumors.
Topics: Animals; Antilymphocyte Serum; Cell Division; Cyclic AMP; Cyclic GMP; Depression, Chemical; Immunosu | 1974 |