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indomethacin and EHS Tumor

indomethacin has been researched along with EHS Tumor in 42 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"Indomethacin, a non-steroidal anti-inflammatory drug which is also a calcium antagonist and an inhibitor of prostaglandin synthesis was observed to have a chemotherapeutic effect in a mouse fibrosarcoma."7.67Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma. ( Shenoy, MA; Singh, BB, 1989)
"Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice."5.28Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991)
"Indomethacin, a non-steroidal anti-inflammatory drug which is also a calcium antagonist and an inhibitor of prostaglandin synthesis was observed to have a chemotherapeutic effect in a mouse fibrosarcoma."3.67Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma. ( Shenoy, MA; Singh, BB, 1989)
"Indomethacin, an inhibitor of prostaglandin (PG) synthesis, was investigated for its ability to increase radioresponse of two fibrosarcomas, FSA and NFSA, in C3Hf/Kam mice."3.67Increase in radioresponse of murine tumors by treatment with indomethacin. ( Barkley, T; Furuta, Y; Hall, E; Hunter, N; Milas, L, 1988)
"The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth."3.66Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat. ( Peterson, HI, 1983)
"Indomethacin was continuously administered in the drinking water of inbred C3H mice given grafts of syngeneic 3-methylcholanthrene-induced fibrosarcomas."3.66Tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice. ( Lynch, NR; Salomon, JC, 1979)
"The growth of a 3-methylcholanthrene-induced fibrosarcoma of C3H mice was inhibited by aspirin and indomethacin."3.66Mechanism of inhibition of tumour growth by aspirin and indomethacin. ( Astoin, M; Castes, M; Lynch, NR; Salomon, JC, 1978)
" In the present study, [3H]arachidonate-labeled phospholipids of HSDM1C1 cells, a cell line derived from a mouse fibrosarcoma, were examined to determine the donor of the arachidonic acid released upon bradykinin stimulation of the synthesis of PGE2."3.66Bradykinin-stimulated release of [3H]arachidonic acid from phospholipids of HSDM1C1 cells: comparison of diacyl phospholipids and plasmalogens as sources of prostaglandin precursors. ( Blank, ML; Schremmer, JM; Wykle, RL, 1979)
"Indomethacin was provided in the drinking water to explore interactions between host and tumor-derived prostaglandins and proinflammatory cytokines for tumor growth."1.31Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia. ( Axelsson, H; Cahlin, C; Körner, A; Lundholm, K; Svanberg, E; Wang, W, 2000)
"Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice."1.28Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991)
"Indomethacin treatment prolonged survival and 40% of these tumour-bearers were 'complete responders'."1.28The effect of indomethacin on food and water intake, motor activity and survival in tumour-bearing rats. ( Gelin, J; Lundholm, K; Sandström, R, 1990)
"Indomethacin has little effect on the development of this suppressor cell activity."1.27Modification by biological products of the generation of suppressor cells in culture. ( Ehrke, MJ; Leung, KH; Mihich, E, 1983)
"Indomethacin treatment showed Prostaglandin E2 was not a direct in vitro factor in Ia antigen-mediated reduction of splenic M phi MLR stimulatory activity."1.27Variations in macrophage antigen phenotype: a correlation between Ia antigen reduction and immune dysfunction during tumor growth. ( Elgert, KD; Garner, RE; Malick, AP, 1986)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199027 (64.29)18.7374
1990's13 (30.95)18.2507
2000's2 (4.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, W2
Andersson, M1
Lõnnroth, C2
Svanberg, E2
Lundholm, K4
Sundbeck, A1
Karlsson, L1
Lilja, J1
Peterson, HI2
Leung, KH2
Ehrke, MJ2
Mihich, E2
Fulton, AM1
Levy, JG1
Garrigues, HJ1
Romero, P1
Hellström, I1
Hellström, KE1
Cochran, FR1
Baxter, CS1
Rojo, JM1
Barasoain, I1
Portolés, A1
DeGowin, RL1
Gibson, DP1
Knapp, SA1
Wathen, LM1
Evans, R1
Eidlen, LG1
Hanson, WR1
Zhen, W1
Geng, L1
Hunter, N4
Milas, L7
Cincotta, L1
Foley, JW1
MacEachern, T1
Lampros, E1
Cincotta, AH1
Besa, PC1
Hunter, NR2
Grégoire, V1
Brock, WA1
Hittelman, WN1
Plunkett, W1
Włodarski, K1
Luczak, M1
Galus, R1
Włodarski, P1
Cahlin, C1
Körner, A1
Axelsson, H1
Lynch, NR2
Salomon, JC2
Castes, M1
Astoin, M1
Strausser, HR3
Rosenstein, MM1
Schremmer, JM1
Blank, ML1
Wykle, RL1
Brekke, OL1
Espevik, T1
Bardal, T1
Bjerve, KS1
Gelin, J3
Andersson, C1
Young, MR1
Okada, F1
Tada, M1
Hosokawa, M1
Kobayashi, H1
Ito, H1
Nakayama, T1
Sandström, R1
Wlodarski, KH1
Zajícová, A1
Holán, V1
Furuta, Y3
Nishiguchi, I1
Runkel, S1
Shenoy, MA1
Singh, BB1
Kim, B1
Warnaka, P1
Hall, ER1
Sanduja, S1
Barkley, T2
Nakata, K1
Kashimoto, S1
Yoshida, H1
Oku, T1
Nakamura, S1
Moldawer, LL1
deMan, P1
Svanborg-Eden, C1
Lowry, SF1
Lundholm, KG1
Hall, E1
Garner, RE1
Malick, AP1
Elgert, KD1
Ohshika, Y1
Umesaki, N1
Kawabata, M1
Sako, H1
Sugawa, T1
Nanjo, M1
Yoshie, O1
Aso, H1
Ebina, T1
Ishida, N1
Jones, GR1
Thatcher, R1
Tashjian, AH1
Voelkel, EF1
Goldhaber, P1
Levine, L1
Humes, JL2
Cupo, JJ1

Reviews

1 review available for indomethacin and EHS Tumor

ArticleYear
Immunosuppression as a homeostatic mechanism in disease and aging.
    Advances in experimental medicine and biology, 1979, Volume: 121B

    Topics: Aging; Animals; B-Lymphocytes; Homeostasis; Immunity; Immunosuppression Therapy; Indomethacin; Macro

1979

Other Studies

41 other studies available for indomethacin and EHS Tumor

ArticleYear
Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexia.
    International journal of cancer, 2005, Jul-01, Volume: 115, Issue:4

    Topics: Animals; Base Sequence; Body Weight; Cachexia; Dinoprostone; Disease Models, Animal; DNA Primers; DN

2005
Inhibition of tumour vascularization by tranexamic acid. Experimental studies on possible mechanisms.
    Anticancer research, 1981, Volume: 1, Issue:5

    Topics: Angiography; Animals; Cyclohexanecarboxylic Acids; Indomethacin; Microscopy, Electron; Muscles; Neop

1981
Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
    Invasion & metastasis, 1983, Volume: 3, Issue:3

    Topics: Animals; Aspirin; Diclofenac; Fibrosarcoma; Indomethacin; Liver Neoplasms, Experimental; Neoplasm Tr

1983
Modification by biological products of the generation of suppressor cells in culture.
    Immunopharmacology, 1983, Volume: 5, Issue:3

    Topics: Animals; Antigens; Cells, Cultured; Culture Media; Dinoprostone; Female; Indomethacin; Mast-Cell Sar

1983
The possible role of prostaglandins in mediating immune suppression by nonspecific T suppressor cells.
    Cellular immunology, 1980, Volume: 52, Issue:1

    Topics: Animals; Antibody Formation; Cell Adhesion; Female; Immune Tolerance; Indomethacin; Mice; Prostaglan

1980
Adherent cells (macrophages?) in tumor-bearing mice suppress MLC responses.
    Cellular immunology, 1981, May-01, Volume: 60, Issue:1

    Topics: Animals; Cell Adhesion; Fibrosarcoma; Immunosuppression Therapy; Indomethacin; Lymphocyte Culture Te

1981
Carrageenan-induced suppression of T-lymphocyte proliferation in the rat: abrogation of suppressor factor production by the prostaglandin synthesis inhibitors, indomethacin and ETYA.
    Immunobiology, 1984, Volume: 166, Issue:3

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Carrageenan; Cell Division; Cells, Cultured; Fatty Acids,

1984
Variable effects of indomethacin and four related compounds on lymphocyte blastogenesis and cell-mediated cytotoxicity.
    International journal of clinical pharmacology, therapy, and toxicology, 1981, Volume: 19, Issue:9

    Topics: Animals; B-Lymphocytes; Concanavalin A; Cytotoxicity, Immunologic; Esters; In Vitro Techniques; Indo

1981
Modulation of the development of cell-mediated immunity: possible role of the products of the cyclo-oxygenase and the lipoxygenase pathways of arachidonic acid metabolism.
    International journal of immunopharmacology, 1982, Volume: 4, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Female; Immunity, Cellular;

1982
Tumor-induced suppression of marrow stromal colonies.
    Experimental hematology, 1981, Volume: 9, Issue:7

    Topics: Animals; Bone Marrow Cells; Carcinoma, Ehrlich Tumor; Cells, Cultured; Colony-Forming Units Assay; C

1981
The role of the inflammatory response during tumor growth.
    Advances in experimental medicine and biology, 1982, Volume: 155

    Topics: Animals; Cell Division; Hydrocortisone; Indomethacin; Inflammation; Macrophages; Mice; Neutrophils;

1982
The prostaglandin E1 analog, misoprostol, a normal tissue protector, does not protect four murine tumors in vivo from radiation injury.
    Radiation research, 1995, Volume: 142, Issue:3

    Topics: Animals; Cell Division; Dose-Response Relationship, Radiation; Female; Indomethacin; Lung Neoplasms;

1995
Novel photodynamic effects of a benzophenothiazine on two different murine sarcomas.
    Cancer research, 1994, Mar-01, Volume: 54, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry, Physical; Disease Mode

1994
Improvement in radiotherapy for a murine sarcoma by indomethacin plus WR-2721.
    Radiation research, 1993, Volume: 135, Issue:1

    Topics: Amifostine; Animals; Contracture; Drug Therapy, Combination; Indomethacin; Male; Mice; Mice, Inbred

1993
Improvement in the therapeutic ratio of radiotherapy for a murine sarcoma by indomethacin plus fludarabine.
    Radiation research, 1996, Volume: 146, Issue:5

    Topics: Animals; Antineoplastic Agents; Indomethacin; Male; Mice; Mice, Inbred C3H; Prostaglandin Antagonist

1996
Local hypertrophic/hyperplastic changes of keratinizing squamous epithelium of pinna induced by concanavalin A and other immunomodulators in mice.
    Folia biologica, 1999, Volume: 45, Issue:5

    Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Transplantatio

1999
Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia.
    Cancer research, 2000, Oct-01, Volume: 60, Issue:19

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Body Weight; Cachexia; Cell Division;

2000
Tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice.
    Journal of the National Cancer Institute, 1979, Volume: 62, Issue:1

    Topics: Animals; BCG Vaccine; Female; Fibrosarcoma; Immunotherapy; Indomethacin; Male; Mice; Mice, Inbred C3

1979
Mechanism of inhibition of tumour growth by aspirin and indomethacin.
    British journal of cancer, 1978, Volume: 38, Issue:4

    Topics: Animals; Antibodies, Neoplasm; Aspirin; Female; Fibrosarcoma; Hemolytic Plaque Technique; Immunosupp

1978
Bradykinin-stimulated release of [3H]arachidonic acid from phospholipids of HSDM1C1 cells: comparison of diacyl phospholipids and plasmalogens as sources of prostaglandin precursors.
    Prostaglandins, 1979, Volume: 18, Issue:4

    Topics: Animals; Arachidonic Acids; Bradykinin; Cell Line; Fibrosarcoma; Indomethacin; Mice; Phospholipids;

1979
Effects of n-3 and n-6 fatty acids on tumor necrosis factor cytotoxicity in WEHI fibrosarcoma cells.
    Lipids, 1992, Volume: 27, Issue:3

    Topics: Animals; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Survival; Clone Cells; Dexamethaso

1992
Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia.
    Cancer research, 1991, Feb-01, Volume: 51, Issue:3

    Topics: Animals; Body Weight; Cachexia; Cyclosporins; Eating; Female; Indomethacin; Interleukin-1; Interleuk

1991
Association of increased tumor cell responsiveness to prostaglandin E2 with more aggressive tumor behavior.
    Invasion & metastasis, 1991, Volume: 11, Issue:1

    Topics: Animals; Cell Line; Cell Movement; Clone Cells; Dinoprostone; Fibrosarcoma; Genetic Variation; Indom

1991
Improvement in therapeutic ratio of radiotherapy for a murine sarcoma by indomethacin plus misonidazole.
    Cancer research, 1991, Jul-15, Volume: 51, Issue:14

    Topics: Animals; Drug Therapy, Combination; Female; Indomethacin; Mice; Mice, Inbred C3H; Misonidazole; Radi

1991
The effect of indomethacin on food and water intake, motor activity and survival in tumour-bearing rats.
    European journal of cancer (Oxford, England : 1990), 1990, Volume: 26, Issue:7

    Topics: Animals; Drinking; Eating; Indomethacin; Motor Activity; Rats; Rats, Inbred Strains; Sarcoma, Experi

1990
Indomethacin influences Moloney's sarcoma and associated periosteal osteogenesis in the mouse.
    Acta orthopaedica Scandinavica, 1990, Volume: 61, Issue:5

    Topics: Animals; Indomethacin; Male; Mice; Osteogenesis; Periosteum; Sarcoma, Experimental

1990
Active suppression of the proliferative response to interleukin-2 in tumour-bearing mice.
    Folia biologica, 1990, Volume: 36, Issue:6

    Topics: Animals; Cell Division; Cells, Cultured; Culture Media; Indomethacin; Interleukin-1; Interleukin-2;

1990
Dependence of indomethacin-induced potentiation of murine tumor radioresponse on tumor host immunocompetence.
    Cancer research, 1990, Aug-01, Volume: 50, Issue:15

    Topics: Animals; Cell Division; Fibrosarcoma; Indomethacin; Mice; Mice, Inbred C3H; Mice, Nude; Radiation-Se

1990
Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma.
    Cancer letters, 1989, Volume: 45, Issue:3

    Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Fibrosarcoma; Hyperthermia, Induced; Indo

1989
Indomethacin-enhanced immunotherapy of pulmonary metastases using IL-2 and IFN-alpha.
    Surgery, 1989, Volume: 106, Issue:2

    Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Cell Division; Female; Immunotherapy; Indomethacin

1989
Prostaglandin production by murine tumors as a predictor for therapeutic response to indomethacin.
    Cancer research, 1988, Jun-01, Volume: 48, Issue:11

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Biomarkers, Tumor; Carbo

1988
Augmented antitumor effect of recombinant human interleukin-1 alpha by indomethacin.
    Cancer research, 1988, Feb-01, Volume: 48, Issue:3

    Topics: Adenocarcinoma; Animals; Cell Division; Drug Administration Schedule; Drug Synergism; Indomethacin;

1988
Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma.
    Biochemical and biophysical research communications, 1988, Dec-15, Volume: 157, Issue:2

    Topics: Animals; Indomethacin; Interleukin-6; Interleukins; Mice; Sarcoma, Experimental; Serum Amyloid P-Com

1988
Increase in radioresponse of murine tumors by treatment with indomethacin.
    Cancer research, 1988, Jun-01, Volume: 48, Issue:11

    Topics: Animals; Cell Survival; Combined Modality Therapy; Female; Fibrosarcoma; Indomethacin; Male; Mice; M

1988
Variations in macrophage antigen phenotype: a correlation between Ia antigen reduction and immune dysfunction during tumor growth.
    Journal of leukocyte biology, 1986, Volume: 40, Issue:5

    Topics: Animals; Antigen-Presenting Cells; Antigens, Surface; Cells, Cultured; Histocompatibility Antigens C

1986
[Evaluation of indomethacin in non-specific immunotherapy].
    Nihon Gan Chiryo Gakkai shi, 1986, Aug-20, Volume: 21, Issue:7

    Topics: Animals; Biological Products; Drug Synergism; Female; Humans; Indomethacin; Interleukin-1; Macrophag

1986
[Antitumor effect of human recombinant interferon-alpha A/D in mice(I): Comparison between systemic and lesional treatment of meth-A sarcoma in BALB/c mice].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:3 Pt 1

    Topics: Animals; Cyclophosphamide; Drug Therapy, Combination; Female; Indomethacin; Injections; Interferon T

1985
A comparison of the effects of the optical isomers of isoproterenol on energy metabolism in a mouse sarcoma.
    Experientia, 1985, Aug-15, Volume: 41, Issue:8

    Topics: Adenine Nucleotides; Animals; Energy Metabolism; Free Radicals; Indomethacin; Isoproterenol; Mice; O

1985
Prostaglandins, calcium metabolism and cancer.
    Federation proceedings, 1974, Volume: 33, Issue:1

    Topics: Animals; Aspirin; Bone and Bones; Bone Resorption; Calcium; Calcium Radioisotopes; Cells, Cultured;

1974
Prostaglandins and cyclic nucleotides in Moloney sarcoma tumors.
    Prostaglandins, 1974, Jan-25, Volume: 5, Issue:2

    Topics: Animals; Arachidonic Acids; Bucladesine; Chromatography, Gel; Chromatography, Thin Layer; Cyclic AMP

1974
Effects of indomethacin on Moloney sarcoma virus-induced tumors.
    Prostaglandins, 1974, Jun-25, Volume: 6, Issue:6

    Topics: Animals; Antilymphocyte Serum; Cell Division; Cyclic AMP; Cyclic GMP; Depression, Chemical; Immunosu

1974