indomethacin has been researched along with E coli Infections in 33 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We determined the importance of prostanoid production in the enhanced protein loss observed during acute peritonitis by inhibition experiments using indomethacin, an inhibitor of cyclooxygenase activity." | 7.71 | Effect of indomethacin on peritoneal protein loss in a rabbit model of peritonitis. ( Cheung, AK; Kamerath, CD; Leypoldt, JK; Peng, H; Reimer, LG, 2001) |
| "Pretreatment with indomethacin did not result in improved fetal survival." | 5.29 | A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy. ( Gibbs, RS; Heddleston, L; McDuffie, RS, 1993) |
| "Sepsis was produced in piglets by bolus intravenous injection of 10(9) live Escherichia coli followed by an infusion of 10(9) E." | 5.27 | Indomethacin and the gastric mucosal blood flow changes of sepsis. ( Nilsson, LO; Stein, TA; Stone, AM; Wise, L, 1983) |
| "We determined the importance of prostanoid production in the enhanced protein loss observed during acute peritonitis by inhibition experiments using indomethacin, an inhibitor of cyclooxygenase activity." | 3.71 | Effect of indomethacin on peritoneal protein loss in a rabbit model of peritonitis. ( Cheung, AK; Kamerath, CD; Leypoldt, JK; Peng, H; Reimer, LG, 2001) |
| "We have recently shown that indomethacin and ASA diminish the elevated blood flow, protein exudation, and leukocyte infiltration during acute inflammation induced by killed Escherichia coli, the reversed Arthus reaction, or zymosan-activated plasma (ZAP; C5ades-arg) in rabbit skin." | 3.66 | Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits. ( Issekutz, AC, 1983) |
| "Treatment with Indomethacin had no pronounced effect on the immune system or bacterial burden." | 1.48 | A novel model to study neonatal Escherichia coli sepsis and the effect of treatment on the human immune system using humanized mice. ( Entleutner, K; Ernst, W; Fill Malfertheiner, S; Schlieckau, F; Schulz, D; Seelbach-Goebel, B, 2018) |
| "Pretreatment with indomethacin, a nonselective cyclooxygenase inhibitor, completely blocked the early rise in plasma corticosterone, but not at 2 h, whereas pretreatment with IL-6 antibodies had no effect on the early rise in corticosterone but attenuated corticosterone at 2 h." | 1.37 | Time-dependent mediators of HPA axis activation following live Escherichia coli. ( Camp, RM; Johnson, JD; Porterfield, VM; Zimomra, ZR, 2011) |
| " long-term administration of endotoxin on gastric resistance to damage and on expression of NOS and prostaglandin synthesis were compared." | 1.30 | Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage. ( Asfaha, S; Brown, ML; Ferraz, JG; McKnight, W; Reuter, BK; Sharkey, KA; Tigley, AW; Wallace, JL, 1997) |
| "Sepsis was induced in rats by implanting fecal pellets containing Escherichia coli (150 CFU) and Bacteroides fragilis (10(4) CFU) into the abdominal cavity." | 1.30 | Prostaglandin E2 modulation of p59fyn tyrosine kinase in T lymphocytes during sepsis. ( Choudhry, MA; Sayeed, MM; Uddin, S, 1998) |
| "Pretreatment with indomethacin did not result in improved fetal survival." | 1.29 | A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy. ( Gibbs, RS; Heddleston, L; McDuffie, RS, 1993) |
| "Sepsis was produced in piglets by bolus intravenous injection of 10(9) live Escherichia coli followed by an infusion of 10(9) E." | 1.27 | Indomethacin and the gastric mucosal blood flow changes of sepsis. ( Nilsson, LO; Stein, TA; Stone, AM; Wise, L, 1983) |
| "Dazoxiben blocked the increase in plasma TXB2, prevented pulmonary hypertension, and attenuated the increase in EVLW after E." | 1.27 | Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion. ( Carrico, CJ; Harlan, J; Hildebrandt, J; Price, S; Winn, R, 1986) |
| "Treatment with indomethacin prevented the 1-2 degrees C increase in body temperature observed in septic animals." | 1.27 | Fever is not responsible for the elevated glucose kinetics in sepsis. ( Bagby, GJ; Blakesley, HL; Lang, CH; Spitzer, JJ, 1987) |
| "A rabbit model of septic shock was used to determine if myocardial dysfunction is a common component of shock due to diverse neonatal pathogens, and prostaglandins modulate septic myocardial dysfunction." | 1.27 | The comparison of myocardial dysfunction in three forms of experimental septic shock. ( Boerth, RC; Chartrand, SA; Olson, RD; Peevy, KJ; Reed, T, 1986) |
| "Naproxen proved to be an effective inhibitor of prostaglandin synthesis, as did indomethacin." | 1.26 | The effect of antidiuretic hormone, indomethacin and naproxen on prostaglandin synthesis of experimentally infected and healthy kidneys. ( Kaihola, HL; Kangas, L; Nieminen, L; Pulkkinen, M; Túri, S, 1982) |
| "Indomethacin did not inhibit the antibacterial effect of gentamycin and, administered alone, it increased the renal concentration ability." | 1.26 | Indomethacin and gentamycin treatment in experimental kidney infection. ( Farkas, E; Petheö, G; Sallai, J; Túri, S, 1982) |
| "Indomethacin and ASA were also administered locally intradermally (id) into skin sites together with the E." | 1.26 | The effect of nonsteroidal anti-inflammatory agents on E. coli-induced inflammation. ( Bhimji, S; Issekutz, AC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (60.61) | 18.7374 |
| 1990's | 7 (21.21) | 18.2507 |
| 2000's | 4 (12.12) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schlieckau, F | 1 |
| Schulz, D | 1 |
| Fill Malfertheiner, S | 1 |
| Entleutner, K | 1 |
| Seelbach-Goebel, B | 1 |
| Ernst, W | 1 |
| Furtado, N | 1 |
| Beier, UH | 1 |
| Gorla, SR | 1 |
| Fornell, L | 1 |
| Lumpaopong, A | 1 |
| Radhakrishnan, J | 1 |
| John, E | 1 |
| Zimomra, ZR | 1 |
| Porterfield, VM | 1 |
| Camp, RM | 1 |
| Johnson, JD | 1 |
| Wang, W | 1 |
| Zolty, E | 1 |
| Falk, S | 1 |
| Summer, S | 1 |
| Stearman, R | 1 |
| Geraci, M | 1 |
| Schrier, R | 1 |
| Issekutz, AC | 2 |
| Glauser, MP | 1 |
| Francioli, PB | 1 |
| Bille, J | 1 |
| Bonard, M | 1 |
| Meylan, P | 1 |
| Nilsson, LO | 1 |
| Stone, AM | 1 |
| Stein, TA | 1 |
| Wise, L | 1 |
| Fink, MP | 2 |
| MacVittie, TJ | 2 |
| Casey, LC | 2 |
| Miller, T | 1 |
| Marshall, E | 1 |
| Short, BL | 1 |
| Gardiner, M | 1 |
| Walker, RI | 1 |
| Jones, SR | 1 |
| Fletcher, JR | 2 |
| Túri, S | 2 |
| Pulkkinen, M | 1 |
| Kaihola, HL | 1 |
| Kangas, L | 1 |
| Nieminen, L | 1 |
| Sallai, J | 1 |
| Farkas, E | 1 |
| Petheö, G | 1 |
| Bhimji, S | 1 |
| Heddleston, L | 1 |
| McDuffie, RS | 1 |
| Gibbs, RS | 1 |
| Ferraz, JG | 1 |
| Sharkey, KA | 1 |
| Reuter, BK | 1 |
| Asfaha, S | 1 |
| Tigley, AW | 1 |
| Brown, ML | 1 |
| McKnight, W | 1 |
| Wallace, JL | 1 |
| Faggioni, R | 1 |
| Shigenaga, J | 1 |
| Moser, A | 1 |
| Feingold, KR | 1 |
| Grunfeld, C | 1 |
| Choudhry, MA | 1 |
| Uddin, S | 1 |
| Sayeed, MM | 1 |
| Myers, TP | 1 |
| Myers, PR | 1 |
| Adams, HR | 1 |
| Parker, JL | 1 |
| Peng, H | 1 |
| Cheung, AK | 1 |
| Reimer, LG | 1 |
| Kamerath, CD | 1 |
| Leypoldt, JK | 1 |
| Abdul-Wahid, FS | 1 |
| Qureshi, A | 1 |
| Soon-Keng, C | 1 |
| Rasmussen, LT | 1 |
| Fandrem, J | 1 |
| Seljelid, R | 1 |
| Waymack, JP | 1 |
| Guzman, RF | 1 |
| Mason, AD | 1 |
| Pruitt, BA | 1 |
| Lugon, JR | 1 |
| Boim, MA | 1 |
| Ramos, OL | 1 |
| Ajzen, H | 1 |
| Schor, N | 1 |
| Langhans, W | 1 |
| Harlacher, R | 1 |
| Scharrer, E | 1 |
| Winn, R | 2 |
| Enderson, B | 1 |
| Price, S | 2 |
| Rice, CL | 1 |
| Harlan, J | 1 |
| Carrico, CJ | 1 |
| Hildebrandt, J | 1 |
| Lang, CH | 1 |
| Bagby, GJ | 1 |
| Blakesley, HL | 1 |
| Spitzer, JJ | 1 |
| Svanborg Edén, C | 1 |
| Linder, H | 1 |
| de Man, P | 1 |
| Mattsby-Baltzer, I | 1 |
| Bone, RC | 1 |
| Jacobs, ER | 1 |
| Wilson, FJ | 1 |
| Peevy, KJ | 1 |
| Reed, T | 1 |
| Chartrand, SA | 1 |
| Olson, RD | 1 |
| Boerth, RC | 1 |
| Hall-Angerås, M | 1 |
| Säljö, A | 1 |
| Hasselgren, PO | 1 |
33 other studies available for indomethacin and E coli Infections
| Article | Year |
|---|---|
A novel model to study neonatal Escherichia coli sepsis and the effect of treatment on the human immune system using humanized mice.
Topics: Animals; Betamethasone; Bone Marrow; Cytokines; Disease Models, Animal; Escherichia coli; Escherichi | 2018 |
The effect of indomethacin on systemic and renal hemodynamics in neonatal piglets during experimental endotoxemia.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Blood Press | 2008 |
Time-dependent mediators of HPA axis activation following live Escherichia coli.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Escherichia coli; Escherichia coli Infe | 2011 |
Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Animals | 2007 |
Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits.
Topics: Aging; Animals; Arthus Reaction; Escherichia coli Infections; Exudates and Transudates; Glucocortico | 1983 |
Effect of indomethacin on the incidence of experimental Escherichia coli pyelonephritis.
Topics: Animals; Escherichia coli Infections; Indomethacin; Male; Pyelonephritis; Rats; Ureteral Obstruction | 1983 |
Indomethacin and the gastric mucosal blood flow changes of sepsis.
Topics: Animals; Escherichia coli Infections; Gastric Mucosa; Indomethacin; Sepsis; Swine | 1983 |
Effects of nonsteroidal anti-inflammatory drugs on renal function in septic dogs.
Topics: Animals; Anti-Inflammatory Agents; Dogs; Escherichia coli Infections; Female; Glomerular Filtration | 1984 |
Inhibition of prostaglandin synthesis restores normal hemodynamics in canine hyperdynamic sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Dogs; Escherichia coli Infections; Fe | 1984 |
Suppressor cell regulation of cell-mediated immune responses in renal infection in vitro modulation of suppressor cell activity.
Topics: Animals; B-Lymphocytes; Escherichia coli Infections; Female; Immunity, Cellular; Indomethacin; Pyelo | 1980 |
Indomethacin improves survival in gram-negative sepsis.
Topics: Animals; Blood Pressure; Disease Models, Animal; Escherichia coli Infections; Indomethacin; Leukocyt | 1981 |
The effect of antidiuretic hormone, indomethacin and naproxen on prostaglandin synthesis of experimentally infected and healthy kidneys.
Topics: Animals; Arginine Vasopressin; Deamino Arginine Vasopressin; Dinoprost; Escherichia coli Infections; | 1982 |
Indomethacin and gentamycin treatment in experimental kidney infection.
Topics: Animals; Antibodies, Bacterial; Drug Therapy, Combination; Escherichia coli Infections; Female; Gent | 1982 |
The effect of nonsteroidal anti-inflammatory agents on E. coli-induced inflammation.
Topics: Anti-Inflammatory Agents; Aspirin; Capillary Permeability; Dinoprostone; Escherichia coli Infections | 1982 |
The role of prostaglandins in sepsis.
Topics: Animals; Escherichia coli Infections; Indomethacin; Male; Prostaglandin Antagonists; Prostaglandins; | 1982 |
A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy.
Topics: Ampicillin; Animals; Chorioamnionitis; Disease Models, Animal; Drug Therapy, Combination; Escherichi | 1993 |
Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 1997 |
Induction of UCP2 gene expression by LPS: a potential mechanism for increased thermogenesis during infection.
Topics: Animals; Body Temperature Regulation; Escherichia coli Infections; Female; Gene Expression Regulatio | 1998 |
Prostaglandin E2 modulation of p59fyn tyrosine kinase in T lymphocytes during sepsis.
Topics: Animals; Bacteroides fragilis; Bacteroides Infections; Dinoprostone; Enzyme Activation; Escherichia | 1998 |
Enhanced prostanoid-mediated vasorelaxation in pulmonary arteries isolated during experimental endotoxemia.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Calcimycin; Cyclooxygenase Inhibitors; Endothelium, V | 1999 |
Effect of indomethacin on peritoneal protein loss in a rabbit model of peritonitis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cell Movement; Cyclooxygenase Inhibitors; Dialysis Solutions; | 2001 |
Indomethacin-induced rectovaginal fistula in a postpartum patient.
Topics: Adult; Colostomy; Escherichia coli Infections; Fecal Incontinence; Female; Humans; Indomethacin; Obs | 2002 |
Dynamics of blood components and peritoneal fluid during treatment of murine E. coli sepsis with beta-1,3-D-polyglucose derivatives. II. Interleukin 1, tumour necrosis factor, prostaglandin E2, and leukotriene B4.
Topics: Animals; Arachidonic Acids; Ascitic Fluid; beta-Glucans; Cytokines; Dinoprostone; Escherichia coli I | 1990 |
Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis.
Topics: Animals; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Immune Tolerance; In | 1990 |
Renal function and glomerular hemodynamics in male endotoxemic rats.
Topics: Acute Kidney Injury; Animals; Captopril; Escherichia coli Infections; Indomethacin; Kidney; Lipopoly | 1989 |
Verapamil and indomethacin attenuate endotoxin-induced anorexia.
Topics: Animals; Anorexia; Dose-Response Relationship, Drug; Drug Interactions; Escherichia coli Infections; | 1989 |
Indomethacin, but not dazoxiben, reduced lung fluid filtration after E. coli infusion.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Body Water; Cardiac Output; Escherichia coli | 1988 |
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
Topics: Animals; Body Water; Cyclooxygenase Inhibitors; Escherichia coli Infections; Female; Imidazoles; Ind | 1986 |
Fever is not responsible for the elevated glucose kinetics in sepsis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Glucose; Blood Pressure; Cyclooxygenase Inhibito | 1987 |
Adherence, lipopolysaccharide and mucosal inflammation.
Topics: Animals; Bacterial Adhesion; Endotoxins; Escherichia coli Infections; Glycolipids; Humans; Indometha | 1988 |
Increased hemodynamic and survival with endotoxin and septic shock with ibuprofen treatment.
Topics: Animals; Anti-Bacterial Agents; Escherichia coli Infections; Hemodynamics; Ibuprofen; Indomethacin; | 1987 |
The comparison of myocardial dysfunction in three forms of experimental septic shock.
Topics: Animals; Disease Models, Animal; Escherichia coli Infections; Haemophilus Infections; Haemophilus in | 1986 |
Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats.
Topics: Animals; Diethylcarbamazine; Escherichia coli Infections; Indomethacin; Male; Methylprednisolone; Ra | 1986 |