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indomethacin and E coli Infections

indomethacin has been researched along with E coli Infections in 33 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"We determined the importance of prostanoid production in the enhanced protein loss observed during acute peritonitis by inhibition experiments using indomethacin, an inhibitor of cyclooxygenase activity."7.71Effect of indomethacin on peritoneal protein loss in a rabbit model of peritonitis. ( Cheung, AK; Kamerath, CD; Leypoldt, JK; Peng, H; Reimer, LG, 2001)
"Pretreatment with indomethacin did not result in improved fetal survival."5.29A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy. ( Gibbs, RS; Heddleston, L; McDuffie, RS, 1993)
"Sepsis was produced in piglets by bolus intravenous injection of 10(9) live Escherichia coli followed by an infusion of 10(9) E."5.27Indomethacin and the gastric mucosal blood flow changes of sepsis. ( Nilsson, LO; Stein, TA; Stone, AM; Wise, L, 1983)
"We determined the importance of prostanoid production in the enhanced protein loss observed during acute peritonitis by inhibition experiments using indomethacin, an inhibitor of cyclooxygenase activity."3.71Effect of indomethacin on peritoneal protein loss in a rabbit model of peritonitis. ( Cheung, AK; Kamerath, CD; Leypoldt, JK; Peng, H; Reimer, LG, 2001)
"We have recently shown that indomethacin and ASA diminish the elevated blood flow, protein exudation, and leukocyte infiltration during acute inflammation induced by killed Escherichia coli, the reversed Arthus reaction, or zymosan-activated plasma (ZAP; C5ades-arg) in rabbit skin."3.66Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits. ( Issekutz, AC, 1983)
"Treatment with Indomethacin had no pronounced effect on the immune system or bacterial burden."1.48A novel model to study neonatal Escherichia coli sepsis and the effect of treatment on the human immune system using humanized mice. ( Entleutner, K; Ernst, W; Fill Malfertheiner, S; Schlieckau, F; Schulz, D; Seelbach-Goebel, B, 2018)
"Pretreatment with indomethacin, a nonselective cyclooxygenase inhibitor, completely blocked the early rise in plasma corticosterone, but not at 2 h, whereas pretreatment with IL-6 antibodies had no effect on the early rise in corticosterone but attenuated corticosterone at 2 h."1.37Time-dependent mediators of HPA axis activation following live Escherichia coli. ( Camp, RM; Johnson, JD; Porterfield, VM; Zimomra, ZR, 2011)
" long-term administration of endotoxin on gastric resistance to damage and on expression of NOS and prostaglandin synthesis were compared."1.30Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage. ( Asfaha, S; Brown, ML; Ferraz, JG; McKnight, W; Reuter, BK; Sharkey, KA; Tigley, AW; Wallace, JL, 1997)
"Sepsis was induced in rats by implanting fecal pellets containing Escherichia coli (150 CFU) and Bacteroides fragilis (10(4) CFU) into the abdominal cavity."1.30Prostaglandin E2 modulation of p59fyn tyrosine kinase in T lymphocytes during sepsis. ( Choudhry, MA; Sayeed, MM; Uddin, S, 1998)
"Pretreatment with indomethacin did not result in improved fetal survival."1.29A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy. ( Gibbs, RS; Heddleston, L; McDuffie, RS, 1993)
"Sepsis was produced in piglets by bolus intravenous injection of 10(9) live Escherichia coli followed by an infusion of 10(9) E."1.27Indomethacin and the gastric mucosal blood flow changes of sepsis. ( Nilsson, LO; Stein, TA; Stone, AM; Wise, L, 1983)
"Dazoxiben blocked the increase in plasma TXB2, prevented pulmonary hypertension, and attenuated the increase in EVLW after E."1.27Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion. ( Carrico, CJ; Harlan, J; Hildebrandt, J; Price, S; Winn, R, 1986)
"Treatment with indomethacin prevented the 1-2 degrees C increase in body temperature observed in septic animals."1.27Fever is not responsible for the elevated glucose kinetics in sepsis. ( Bagby, GJ; Blakesley, HL; Lang, CH; Spitzer, JJ, 1987)
"A rabbit model of septic shock was used to determine if myocardial dysfunction is a common component of shock due to diverse neonatal pathogens, and prostaglandins modulate septic myocardial dysfunction."1.27The comparison of myocardial dysfunction in three forms of experimental septic shock. ( Boerth, RC; Chartrand, SA; Olson, RD; Peevy, KJ; Reed, T, 1986)
"Naproxen proved to be an effective inhibitor of prostaglandin synthesis, as did indomethacin."1.26The effect of antidiuretic hormone, indomethacin and naproxen on prostaglandin synthesis of experimentally infected and healthy kidneys. ( Kaihola, HL; Kangas, L; Nieminen, L; Pulkkinen, M; Túri, S, 1982)
"Indomethacin did not inhibit the antibacterial effect of gentamycin and, administered alone, it increased the renal concentration ability."1.26Indomethacin and gentamycin treatment in experimental kidney infection. ( Farkas, E; Petheö, G; Sallai, J; Túri, S, 1982)
"Indomethacin and ASA were also administered locally intradermally (id) into skin sites together with the E."1.26The effect of nonsteroidal anti-inflammatory agents on E. coli-induced inflammation. ( Bhimji, S; Issekutz, AC, 1982)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199020 (60.61)18.7374
1990's7 (21.21)18.2507
2000's4 (12.12)29.6817
2010's2 (6.06)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schlieckau, F1
Schulz, D1
Fill Malfertheiner, S1
Entleutner, K1
Seelbach-Goebel, B1
Ernst, W1
Furtado, N1
Beier, UH1
Gorla, SR1
Fornell, L1
Lumpaopong, A1
Radhakrishnan, J1
John, E1
Zimomra, ZR1
Porterfield, VM1
Camp, RM1
Johnson, JD1
Wang, W1
Zolty, E1
Falk, S1
Summer, S1
Stearman, R1
Geraci, M1
Schrier, R1
Issekutz, AC2
Glauser, MP1
Francioli, PB1
Bille, J1
Bonard, M1
Meylan, P1
Nilsson, LO1
Stone, AM1
Stein, TA1
Wise, L1
Fink, MP2
MacVittie, TJ2
Casey, LC2
Miller, T1
Marshall, E1
Short, BL1
Gardiner, M1
Walker, RI1
Jones, SR1
Fletcher, JR2
Túri, S2
Pulkkinen, M1
Kaihola, HL1
Kangas, L1
Nieminen, L1
Sallai, J1
Farkas, E1
Petheö, G1
Bhimji, S1
Heddleston, L1
McDuffie, RS1
Gibbs, RS1
Ferraz, JG1
Sharkey, KA1
Reuter, BK1
Asfaha, S1
Tigley, AW1
Brown, ML1
McKnight, W1
Wallace, JL1
Faggioni, R1
Shigenaga, J1
Moser, A1
Feingold, KR1
Grunfeld, C1
Choudhry, MA1
Uddin, S1
Sayeed, MM1
Myers, TP1
Myers, PR1
Adams, HR1
Parker, JL1
Peng, H1
Cheung, AK1
Reimer, LG1
Kamerath, CD1
Leypoldt, JK1
Abdul-Wahid, FS1
Qureshi, A1
Soon-Keng, C1
Rasmussen, LT1
Fandrem, J1
Seljelid, R1
Waymack, JP1
Guzman, RF1
Mason, AD1
Pruitt, BA1
Lugon, JR1
Boim, MA1
Ramos, OL1
Ajzen, H1
Schor, N1
Langhans, W1
Harlacher, R1
Scharrer, E1
Winn, R2
Enderson, B1
Price, S2
Rice, CL1
Harlan, J1
Carrico, CJ1
Hildebrandt, J1
Lang, CH1
Bagby, GJ1
Blakesley, HL1
Spitzer, JJ1
Svanborg Edén, C1
Linder, H1
de Man, P1
Mattsby-Baltzer, I1
Bone, RC1
Jacobs, ER1
Wilson, FJ1
Peevy, KJ1
Reed, T1
Chartrand, SA1
Olson, RD1
Boerth, RC1
Hall-Angerås, M1
Säljö, A1
Hasselgren, PO1

Other Studies

33 other studies available for indomethacin and E coli Infections

ArticleYear
A novel model to study neonatal Escherichia coli sepsis and the effect of treatment on the human immune system using humanized mice.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2018, Volume: 80, Issue:1

    Topics: Animals; Betamethasone; Bone Marrow; Cytokines; Disease Models, Animal; Escherichia coli; Escherichi

2018
The effect of indomethacin on systemic and renal hemodynamics in neonatal piglets during experimental endotoxemia.
    Pediatric surgery international, 2008, Volume: 24, Issue:8

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Blood Press

2008
Time-dependent mediators of HPA axis activation following live Escherichia coli.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 301, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Escherichia coli; Escherichia coli Infe

2011
Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Animals

2007
Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits.
    Immunopharmacology, 1983, Volume: 5, Issue:3

    Topics: Aging; Animals; Arthus Reaction; Escherichia coli Infections; Exudates and Transudates; Glucocortico

1983
Effect of indomethacin on the incidence of experimental Escherichia coli pyelonephritis.
    Infection and immunity, 1983, Volume: 40, Issue:2

    Topics: Animals; Escherichia coli Infections; Indomethacin; Male; Pyelonephritis; Rats; Ureteral Obstruction

1983
Indomethacin and the gastric mucosal blood flow changes of sepsis.
    Annals of surgery, 1983, Volume: 198, Issue:5

    Topics: Animals; Escherichia coli Infections; Gastric Mucosa; Indomethacin; Sepsis; Swine

1983
Effects of nonsteroidal anti-inflammatory drugs on renal function in septic dogs.
    The Journal of surgical research, 1984, Volume: 36, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Dogs; Escherichia coli Infections; Female; Glomerular Filtration

1984
Inhibition of prostaglandin synthesis restores normal hemodynamics in canine hyperdynamic sepsis.
    Annals of surgery, 1984, Volume: 200, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Dogs; Escherichia coli Infections; Fe

1984
Suppressor cell regulation of cell-mediated immune responses in renal infection in vitro modulation of suppressor cell activity.
    The Journal of clinical investigation, 1980, Volume: 66, Issue:4

    Topics: Animals; B-Lymphocytes; Escherichia coli Infections; Female; Immunity, Cellular; Indomethacin; Pyelo

1980
Indomethacin improves survival in gram-negative sepsis.
    Advances in shock research, 1981, Volume: 6

    Topics: Animals; Blood Pressure; Disease Models, Animal; Escherichia coli Infections; Indomethacin; Leukocyt

1981
The effect of antidiuretic hormone, indomethacin and naproxen on prostaglandin synthesis of experimentally infected and healthy kidneys.
    International urology and nephrology, 1982, Volume: 14, Issue:3

    Topics: Animals; Arginine Vasopressin; Deamino Arginine Vasopressin; Dinoprost; Escherichia coli Infections;

1982
Indomethacin and gentamycin treatment in experimental kidney infection.
    International urology and nephrology, 1982, Volume: 14, Issue:4

    Topics: Animals; Antibodies, Bacterial; Drug Therapy, Combination; Escherichia coli Infections; Female; Gent

1982
The effect of nonsteroidal anti-inflammatory agents on E. coli-induced inflammation.
    Immunopharmacology, 1982, Volume: 4, Issue:1

    Topics: Anti-Inflammatory Agents; Aspirin; Capillary Permeability; Dinoprostone; Escherichia coli Infections

1982
The role of prostaglandins in sepsis.
    Scandinavian journal of infectious diseases. Supplementum, 1982, Volume: 31

    Topics: Animals; Escherichia coli Infections; Indomethacin; Male; Prostaglandin Antagonists; Prostaglandins;

1982
A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy.
    American journal of obstetrics and gynecology, 1993, Volume: 169, Issue:3

    Topics: Ampicillin; Animals; Chorioamnionitis; Disease Models, Animal; Drug Therapy, Combination; Escherichi

1993
Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage.
    Gastroenterology, 1997, Volume: 113, Issue:1

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;

1997
Induction of UCP2 gene expression by LPS: a potential mechanism for increased thermogenesis during infection.
    Biochemical and biophysical research communications, 1998, Mar-06, Volume: 244, Issue:1

    Topics: Animals; Body Temperature Regulation; Escherichia coli Infections; Female; Gene Expression Regulatio

1998
Prostaglandin E2 modulation of p59fyn tyrosine kinase in T lymphocytes during sepsis.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Jan-15, Volume: 160, Issue:2

    Topics: Animals; Bacteroides fragilis; Bacteroides Infections; Dinoprostone; Enzyme Activation; Escherichia

1998
Enhanced prostanoid-mediated vasorelaxation in pulmonary arteries isolated during experimental endotoxemia.
    Shock (Augusta, Ga.), 1999, Volume: 11, Issue:6

    Topics: Acetylcholine; Adenosine Diphosphate; Animals; Calcimycin; Cyclooxygenase Inhibitors; Endothelium, V

1999
Effect of indomethacin on peritoneal protein loss in a rabbit model of peritonitis.
    Kidney international, 2001, Volume: 59, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cell Movement; Cyclooxygenase Inhibitors; Dialysis Solutions;

2001
Indomethacin-induced rectovaginal fistula in a postpartum patient.
    Diseases of the colon and rectum, 2002, Volume: 45, Issue:6

    Topics: Adult; Colostomy; Escherichia coli Infections; Fecal Incontinence; Female; Humans; Indomethacin; Obs

2002
Dynamics of blood components and peritoneal fluid during treatment of murine E. coli sepsis with beta-1,3-D-polyglucose derivatives. II. Interleukin 1, tumour necrosis factor, prostaglandin E2, and leukotriene B4.
    Scandinavian journal of immunology, 1990, Volume: 32, Issue:4

    Topics: Animals; Arachidonic Acids; Ascitic Fluid; beta-Glucans; Cytokines; Dinoprostone; Escherichia coli I

1990
Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis.
    Burns : journal of the International Society for Burn Injuries, 1990, Volume: 16, Issue:1

    Topics: Animals; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Immune Tolerance; In

1990
Renal function and glomerular hemodynamics in male endotoxemic rats.
    Kidney international, 1989, Volume: 36, Issue:4

    Topics: Acute Kidney Injury; Animals; Captopril; Escherichia coli Infections; Indomethacin; Kidney; Lipopoly

1989
Verapamil and indomethacin attenuate endotoxin-induced anorexia.
    Physiology & behavior, 1989, Volume: 46, Issue:3

    Topics: Animals; Anorexia; Dose-Response Relationship, Drug; Drug Interactions; Escherichia coli Infections;

1989
Indomethacin, but not dazoxiben, reduced lung fluid filtration after E. coli infusion.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 64, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Body Water; Cardiac Output; Escherichia coli

1988
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
    The Journal of surgical research, 1986, Volume: 41, Issue:2

    Topics: Animals; Body Water; Cyclooxygenase Inhibitors; Escherichia coli Infections; Female; Imidazoles; Ind

1986
Fever is not responsible for the elevated glucose kinetics in sepsis.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1987, Volume: 185, Issue:4

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Glucose; Blood Pressure; Cyclooxygenase Inhibito

1987
Adherence, lipopolysaccharide and mucosal inflammation.
    Monographs in allergy, 1988, Volume: 24

    Topics: Animals; Bacterial Adhesion; Endotoxins; Escherichia coli Infections; Glycolipids; Humans; Indometha

1988
Increased hemodynamic and survival with endotoxin and septic shock with ibuprofen treatment.
    Progress in clinical and biological research, 1987, Volume: 236A

    Topics: Animals; Anti-Bacterial Agents; Escherichia coli Infections; Hemodynamics; Ibuprofen; Indomethacin;

1987
The comparison of myocardial dysfunction in three forms of experimental septic shock.
    Pediatric research, 1986, Volume: 20, Issue:12

    Topics: Animals; Disease Models, Animal; Escherichia coli Infections; Haemophilus Infections; Haemophilus in

1986
Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats.
    Circulatory shock, 1986, Volume: 20, Issue:3

    Topics: Animals; Diethylcarbamazine; Escherichia coli Infections; Indomethacin; Male; Methylprednisolone; Ra

1986