indomethacin has been researched along with Disease Models, Animal in 1046 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy." | 8.02 | Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021) |
| " speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs." | 8.02 | Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021) |
| "The aim of the study was to investigate the effects of four Aronia melanocarpa-based juices in a rat model of indomethacin-induced gastric ulceration." | 7.91 | Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers. ( Denev, P; Eftimov, M; Georgieva, A; Kuzmanov, A; Kuzmanov, K; Kuzmanova, V; Tzaneva, M; Valcheva-Kuzmanova, S, 2019) |
| "The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats." | 7.88 | Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms. ( Chen, H; Lai, X; Li, C; Lin, G; Luo, C; Su, Z; Tan, L; Wang, Y; Xie, J; Zeng, H, 2018) |
| "In this study, we aimed to investigate the effect of indomethacin and dimethyl sulfoxide (DMSO), well-known antioxidant and anti-inflammatory agents, to heal eye burns induced with hydrofluoric acid in rabbits." | 7.85 | Dimethyl sulfoxide but not indomethacin is efficient for healing in hydrofluoric acid eye burns. ( Altan, S; Oğurtan, Z, 2017) |
| " After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days." | 7.85 | Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats. ( Eyoum Bille, B; Kouitcheu Mabeku, LB; Nanfack Nana, B; Nguepi, E; Tchuenteu Tchuenguem, R, 2017) |
| "The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats." | 7.83 | Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata. ( Garuba, T; Ismail, NO; Sabiu, S; Sulyman, AO; Sunmonu, TO, 2016) |
| " The aim was to scientifically evaluate the possible gastroprotective effect and the underlying mechanisms of pogostone against indomethacin-induced gastric ulcer in rats." | 7.83 | The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. ( Chen, HM; Chen, XY; Fu, LD; Huang, XQ; Lai, XP; Liang, YZ; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Zhang, X; Zhang, ZB; Zheng, YF, 2016) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 7.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| "Cu-Indo gel at lower doses was superior to or at least as effective as its parent substance, indomethacin, in most of the studied parameters of inflammation." | 7.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| " This study investigated the anti-ulcerogenic and antioxidant activities of aqueous extract of Carica papaya seed against indomethacin-induced peptic ulcer in male rats." | 7.81 | Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. ( Adaja, MC; Ajiboye, TO; Oloyede, HO; Salawu, MO, 2015) |
| "To investigate the effects of nilotinib in a rat model of indomethacin-induced enterocolitis." | 7.81 | Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. ( Ataca, P; Borekci, E; Dervis Hakim, G; Karaman, M; Sagol, O; Soyturk, M; Unlu, M; Yilmaz, O, 2015) |
| "To evaluate the renoprotection effects of non-steroidal anti-inflammatory drugs (NSAIDs) in renal ischemia-reperfusion injury (IRI) and the cyclooxygenase (COX)-1/2 blockade association by indomethacin (IMT) in the mice model." | 7.80 | Protective effect of indomethacin in renal ischemia-reperfusion injury in mice. ( Chen, JH; Chen, RJ; Feng, S; Jiang, H; Jin, J; Lin, C; Wu, JY; Zhou, LJ; Zhu, SH, 2014) |
| "Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin." | 7.80 | Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. ( Argaãaraz, GA; Cavalheiro, EA; Graça Naffah-Mazzacoratti, Md; Perosa, SR; Silva, JA; Vieira, MJ, 2014) |
| " Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test." | 7.79 | Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. ( Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA, 2013) |
| "The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol) alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats." | 7.78 | Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. ( Apikoglu-Rabus, S; Cevikbas, U; Izzettin, FV; Okuyan, B; Sancar, M, 2012) |
| "This study investigates the gastroprotective effects of hecogenin, a steroid saponin isolated from Agave sisalana, on experimental models of gastric ulcer." | 7.78 | Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. ( Arcanjo Moura, B; Barbosa Filho, JM; de Almeida Leal, LK; de Barros Viana, GS; de Castro Brito, GA; dos Santos e Silva, G; Fragoso de Freitas, AP; Lopes Souto, A; Rios Vasconcelos, E; Santos Cerqueira, G; Silveira Macedo, D; Souccar, C, 2012) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 7.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| "This study sought to determine the effect of combined treatment of hypoxia plus indomethacin on pulmonary vascular remodeling in fetal rats." | 7.77 | Fetal pulmonary vascular remodeling in a rat model induced by hypoxia and indomethacin. ( Du, LZ; Gu, WZ; Li, RY; Wu, XL; Xu, XF, 2011) |
| "In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin." | 7.77 | A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis. ( Nagar, S; Rasool, M; Sabina, EP, 2011) |
| "The present study aimed to investigate the effects of indomethacine, montelukast and methylprednisolone in management of experimental otitis media with effusion." | 7.77 | The effects of methylprednisolone, montelukast and indomethacine in experimental otitis media with effusion. ( Aynali, G; Başpinar, S; Gümüş, S; Karahan, N; Tüz, M; Yariktaş, M; Yasan, H, 2011) |
| " Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice." | 7.77 | Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011) |
| "The gastro-protective and antioxidant effects of methanol extract of Ficus asperifolia bark on indomethacin induced gastric ulcer were investigated in male rats." | 7.77 | Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats. ( Bolarinwa, AF; Oyeyemi, WA; Raji, Y; Shittu, ST, 2011) |
| "Minocycline and a non-steroidal anti-inflammatory drug (NSAID) indomethacin, have anti-inflammatory activities and are both used in the management of rheumatoid arthritis." | 7.76 | Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis. ( Abu-Ghefreh, AA; Masocha, W, 2010) |
| "The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model." | 7.76 | Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Hassarajani, SA; Maity, B; Narayan, G, 2010) |
| " The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats." | 7.75 | Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009) |
| "To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers." | 7.75 | EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009) |
| " Next, intestinal inflammation was induced by subcutaneous injections of indomethacin to rats." | 7.74 | Enzyme-modified cheese exerts inhibitory effects on allergen permeation in rats suffering from indomethacin-induced intestinal inflammation. ( Isobe, N; Oda, M; Suzuki, M; Tanabe, S, 2008) |
| "To observe and compare the effect of taurine on contractions of aortic rings isolated from normal (NC) and insulin resistance (IR) Sprague-Dawley rats, and to explore its underlying mechanism(s)." | 7.74 | Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed. ( Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M, 2008) |
| " In the present study, the effect of withaferin A, a steroidal lactone was investigated on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin." | 7.74 | Inhibition of monosodium urate crystal-induced inflammation by withaferin A. ( Chandal, S; Rasool, MK; Sabina, EP, 2008) |
| "APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties." | 7.74 | Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Bhattacharya, S; Chattopadhyay, S, 2007) |
| "The healing activity of malabaricone B and malabaricone C, the major antioxidant constituents of the spice Myristica malabarica against the indomethacin-induced gastric ulceration in mice has been studied." | 7.74 | Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Guha, RK, 2008) |
| "Early postnatal steroids and indomethacin in combination have been shown to increase the risk of spontaneous intestinal perforation (SIP) in infants with extremely low birth weight (ELBW), but the mechanism behind this synergistic effect is unknown." | 7.74 | A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin. ( Aschner, JL; Gaston, BM; Gordon, PV; Herman, AC; Laubach, VE; Marcinkiewicz, M, 2007) |
| "Results of these studies demonstrate that provision of additional NO substrate in the form of L-arginine incites prostaglandin-dependent secretory diarrhea and does not promote epithelial defense or barrier function of C." | 7.74 | Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. ( Coccaro, MR; Foster, DM; Gookin, JL; Stauffer, SH, 2008) |
| "Results of this study indicate that tacrolimus has an important anti-inflammatory property, showing not only inhibition of pro-inflammatory mediators release, but also inhibition of activated leukocyte infiltration into the site of inflammation." | 7.74 | Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch. ( de Liz, R; Fröde, TS; Medeiros, YS; Vigil, SV, 2008) |
| "Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels." | 7.74 | Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Bhattacharya, S; Chattopadhyay, S, 2008) |
| " However, the role of MMPs in indomethacin-induced gastric ulcer and its healing process are not clearly understood." | 7.73 | Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. ( Banerjee, A; Ganguly, K; Kundu, P; Maity, P; Sharma, AV; Swarnakar, S, 2005) |
| "Oral administration for 6 days of 100 mg/kg MMK-1, an agonist peptide selective for the FPRL1 receptor, suppressed alopecia induced by the anticancer drug etoposide in neonatal rats." | 7.73 | Orally administered FPRL1 receptor agonist peptide MMK-1 inhibits etoposide-induced alopecia by a mechanism different from intraperitoneally administered MMK-1. ( Tsuruki, T; Yoshikawa, M, 2006) |
| " Indomethacin abolished the gross mucosal protective effect by 1% AA pretreatment in 8% AA-derived colitis in normal rats while the NS398 had no effect." | 7.72 | Acetic acid-derived prostaglandin-dependent colonic adaptive cytoprotection is preserved in chronic colitis: role of cyclo-oxygenase. ( Asama, T; Chisato, N; Kasai, S; Kono, T; Ohara, K; Yoneda, M, 2003) |
| "We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation." | 7.72 | Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003) |
| "Using automatic erythrocyte aggregometer type MA-1 (Myrenne gmbh, Germany), we investigated the hypothesis that therapeutic effectiveness of quinapril--angiotensin converting enzyme inhibitor (ACEI)--in the treatment of hypertension would correlate with improvement of red blood cell (RBC) aggregability." | 7.72 | Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension. ( Adamek-Guzik, T; Korbut, R; Korbut, RA; Madej, J, 2003) |
| " We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice." | 7.72 | Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004) |
| "The acetone soluble fraction from a crude methanol extract of Stryphnodendron adstringens stem bark (AFSAB) was evaluated in acute (ethanol, indomethacin and hypothermic restraint-stress) and chronic (acetic acid) models of gastric ulceration and on basal and bethanechol-stimulated gastric acid secretion in rats." | 7.71 | The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats. ( Lima, JC; Martins, DT; Rao, VS, 2002) |
| " Ileitis was induced in Sprague-Dawley rats by two injections of indomethacin (7." | 7.71 | Role of intercellular adhesion molecule 1 in indomethacin-induced ileitis. ( Bruewer, M; Cerwinka, WH; Granger, DN; Grisham, MB; Krieglstein, CF; Laroux, FS; Russell, JM; Salter, JW; Schuermann, G, 2001) |
| "We investigated the effect of diacerein, an antiosteoarthritic agent, and its metabolite, rhein, on the production of reactive oxygen species (ROS) from neutrophils as well as the protective effect of diacerein on indomethacin-induced gastric ulceration and its protection mechanism." | 7.71 | Effects of diacerein on indomethacin-induced gastric ulceration. ( Ohmori, K; Tamura, T; Yokoyama, T, 2001) |
| " The antiinflammatory activity of synthetic cannabinoid nabilone in the rat model of carrageenan-induced acute hindpaw inflammation was compared with that of the endocannabinoid palmitoylethanolamide and the nonsteroidal antiinflammatory drug indomethacin." | 7.71 | Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. ( Colleoni, M; Conti, S; Costa, B; Giagnoni, G; Parolaro, D, 2002) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 7.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| " When the eyes were treated with histamine, a complement C5a analogue peptide and hydrogen peroxide, typical signs of uveitis were produced." | 7.70 | Arterially perfused eye model of uveitis. ( Sanderson, SD; Shiels, IA; Taylor, SM, 1999) |
| "The healing of experimental gastric ulcers induced in rats is consistently delayed upon chronic treatment with indomethacin." | 7.70 | A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers. ( Amagase, K; Okabe, S, 1999) |
| " Our aim is to determine the antiinflammatory activity of deferiprone, an oral iron chelator, in experimental colitis and gastritis." | 7.70 | Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats. ( Ablin, J; Karmeli, F; Okon, E; Rachmilewitz, D; Shalev, O, 1999) |
| " In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection." | 7.70 | The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 7.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| "The influence of (+/-)-verapamil and hydralazine on stress- and various chemically-induced gastric ulcers in rats together with their influence on various biochemical parameters which affect the development of the induced ulcers was examined." | 7.69 | Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats. ( al-Bekairi, AM; al-Rajhi, AM; Tariq, M, 1994) |
| "Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice." | 7.69 | Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. ( Chang, LC; Kuo, SC; Raung, SL; Wang, JP, 1995) |
| "To examine the effect of indomethacin, a cyclooxygenase (CO) inhibitor, on laser-induced subretinal neovascularization (SRN) in the monkey." | 7.69 | Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate. ( Hinton, DR; Murphy, TL; Nassaralla, J; Oganesian, A; Ryan, SJ; Sakamoto, T; Soriano, D; Spee, C, 1995) |
| " The anorexia of indomethacin-induced ulcerative ileitis was compared with that of the well-known anorexia of total parenteral nutrition (TPN)." | 7.69 | Mode of food intake reduction in Lewis rats with indomethacin-induced ulcerative ileitis. ( Holtzapple, PG; Levine, RA; Meguid, MM; Nandi, J; Oler, A; Opara, EI; Veerabagu, MP, 1996) |
| "We found indomethacin aggravates healed gastric ulcers (ulcer relapse) in rats." | 7.69 | Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. ( Asano, S; Inada, I; Maeda, R; Murakami, I; Sato, F; Satoh, H; Shino, A, 1997) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 7.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| "The interaction between renal prostaglandins and atrial natriuretic factor (ANF) for the regulation of renal hemodynamic and excretory function was examined in conscious dogs with arteriovenous fistula and chronic compensated high-output heart failure (n = 6)." | 7.69 | Indomethacin attenuates the renal actions of atrial natriuretic factor in dogs with chronic heart failure. ( Freeman, RH; Habibullah, AA; Simmons, JC; Villarreal, D, 1997) |
| "To investigate changes in regional blood flows (RBF) and vascular porosity during the early phase of the autologous collagen II induced arthritis model (CIA) in rats and the possible influence of indomethacin and nitric oxide (NO) synthase on these variables." | 7.69 | Changes in vascular porosity and joint blood flow during development of collagen induced arthritis in the rat. Modulation by indomethacin and L-NAME. ( Andersson, SE; Ekström, GM, 1997) |
| "The role of indomethacin-induced peptic ulceration in gastric acid secretion was investigated using albino rats of Wistar strain in early, mid and late pregnancy." | 7.68 | Role of indomethacin-induced peptic ulceration in gastric acid secretion in pregnant rats. ( Bolarinwa, Y; Evbuomwan, MI, 1993) |
| "The effects of 4-week indomethacin administration (1mg/kg/day, orally) on gastrin cell (G-cell), somatostatin cell (D-cell) and prostaglandin E2 (PGE2) of gastric mucosa were examined in pyloric stenosis rats." | 7.68 | [Effect of indomethacin on endocrine kinetics of the stomach in experimental pyloric stenosis model]. ( Omura, N, 1993) |
| "The role of histamine in neutrophil infiltration and vascular permeability response in carrageenin air pouch inflammation in rats was examined." | 7.68 | Downward regulation of neutrophil infiltration by endogenous histamine without affecting vascular permeability responses in air-pouch-type carrageenin inflammation in rats. ( Hirasawa, N; Mue, S; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1991) |
| "Indomethacin lessens edema after repetitive cerebral ischemia, suggesting that elevations of cyclooxygenase products are responsible, at least in part, for severe brain edema following repetitive ischemia." | 7.68 | Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. ( Betz, AL; Deluga, KS; Plötz, FB, 1991) |
| "The long term effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis in mice were tested under two different treatment protocols." | 7.68 | Effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis of mice. ( Cannon, GW; Cole, BC; Griffiths, MM; McCall, S; Radov, LA; Ward, JR, 1990) |
| "The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats." | 7.67 | The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984) |
| "The pathogenesis of monocrotaline-induced pulmonary hypertension is not clear." | 7.67 | Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension. ( Kanisawa, M; Kato, T; Kitamura, H, 1989) |
| "The effects of indomethacin on antigen induced arthritis in rabbits have been investigated." | 7.67 | Effect of indomethacin on swelling, lymphocyte influx, and cartilage proteoglycan depletion in experimental arthritis. ( Edwards, JC; Henderson, B; Higgs, GA; Pettipher, ER, 1989) |
| "Healing of duodenal ulcers induced by indomethacin + histamine was investigated in rats." | 7.67 | Healing process of duodenal ulcers induced by indomethacin plus histamine in rats. ( Niida, H; Okabe, S; Okada, M; Takeuchi, K, 1989) |
| "Previous studies have shown that indomethacin administered during the early phase of experimental myocarditis may exacerbate the disease process." | 7.67 | Effect of indomethacin in the late phase of coxsackievirus myocarditis in a murine model. ( Khatib, G; Khatib, R; Kloner, R; Rezkalla, S; Smith, F; Sowers, J; Walsh, M, 1988) |
| "The effects of prophylactic and delayed treatment with indomethacin were evaluated in a porcine model of early adult respiratory distress syndrome (ARDS) induced by endotoxaemia." | 7.67 | Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia. ( Borg, T; Gerdin, B; Modig, J, 1986) |
| " In series 1 during acute cardiac failure, indomethacin administration produced striking reductions in RHF but failed to alter the high level of plasma renin activity (PRA)." | 7.66 | Effects of indomethacin in conscious dogs with experimental high-output heart failure. ( Davis, JO; Dietz, JR; Echtenkamp, SF; Freeman, RH; Villarreal, D, 1983) |
| " 9 The results are also discussed in relation to the genesis of aspirin-induced asthma in man." | 7.66 | Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma. ( Ito, Y; Tajima, K, 1981) |
| "The effects of a number of steroids administered intra-articularly in a chronic model of fibrin-induced monoarticular arthritis in the rabbit have been investigated." | 7.66 | The local anti-inflammatory activity of rimexolone (Org 6216) in fibrin-induced monoarticular arthritis and adjuvant-induced arthritis. ( Lewis, AJ, 1980) |
| "The possibility that prostaglandin synthesis inhibition might favorably inhibit the development of animal adult respiratory distress syndrome models was investigated in two groups of dogs; one group was pretreated with indomethacin 3 mg/kg." | 7.66 | Failure of indomethacin to prevent or ameliorate oleic acid pulmonary edema in the dog. ( Blatnick, RA; Goitz, H; Johansen, RK; Pace, NL, 1980) |
| "In the present work it was determined the ability of non-steroidal anti-inflammatory drugs (Diflunisal and Indomethacin) to inhibit formation of "granuloma pouch" exudate induced in rats." | 7.66 | ["Granuloma pouch" reduction after treatment with indomethacin and diflunisal and collateral effects of these drugs on gastric mucosa]. ( Alesse, E; Bruno, G; Cifone, MG; Conti, P; Continenza, MA, 1980) |
| "Experimental models of chronic and acute peptic ulcerations were produced in the albino rats by means of prolonged starvation and indomethacin administration." | 7.66 | Comparative studies on starvation - and indomethacin - induced ulcerations in albino rats. ( Elegbe, RA, 1978) |
| "The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied." | 7.65 | Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977) |
| "A model is described of acute inflammation in the pleural cavity of rats using calcium pyrophosphate as the irritant." | 7.65 | Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation. ( Capasso, F; Deporter, DA; Dunn, CJ; Giroud, JP; Willoughby, DA; Yamamoto, S, 1975) |
| "The effects of single and multiple doses of indomethacin and multiple doses of nicotinic acid upon Escherichia coli endotoxin shock were studied in mongrel dogs anesthetized with sodium pentobarbital." | 7.65 | Effects of indomethacin and nicotinic acid on E. coli endotoxin shock in anesthetized dogs. ( Hilton, JG; Wells, CH, 1976) |
| "Gastric ulcer has been a major cause of morbidity and mortality worldwide, and it has been linked to factors such as nutritional deficiency, smoking, stress, and continuous intake of non-steroidal antiinflammatory drugs (NSAIDs)." | 5.72 | Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model. ( Carvalho, MF; Costa, EA; Fajemiroye, JO; Fava, SA; Ghedini, PC; Gil, ES; Gomes, EH; Macedo, IYL; Martins, JLR; Pinto, EMH; Rocha, FF; Silva, DM; Silva, ON, 2022) |
| "Olmesartan (OLM) has potent anti-oxidant and anti-inflammatory characters, yet having limited bioavailability." | 5.62 | Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway. ( Darwish, SF; El-Dakroury, WA; Radwan, E; Sallam, AM, 2021) |
| "Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels." | 5.62 | The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021) |
| "Gastric ulcers were induced in male Sprague-Dawley (SD) rats with a single oral dose of 150 mg/kg IND." | 5.56 | Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway. ( Cai, X; Chen, X; Hou, X; Peng, J; Peng, Q; Song, H; Xu, F; Yang, T; Yu, R; Zeng, M, 2020) |
| "Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days." | 5.51 | Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice. ( Hajhashemi, V; Mesripour, A; Shahnooshi, S, 2019) |
| "The long-term use of anti-inflammatory drugs is the most common cause of gastric ulcer disease, one of the major gastrointestinal disorders affecting people worldwide." | 5.51 | Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice. ( Alves, GM; Assis, ALEM; Athaydes, BR; Campagnaro, BP; Gomes, JVD; Gonçalves, RCR; Kitagawa, RR; Kuster, RM; Nogueira, BV; Pereira, TMC; Rodrigues, RP; Silveira, D, 2019) |
| "Gastric ulcer is a common problem affecting the gastrointestinal tract." | 5.51 | A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats. ( Abdelwahed, MK; Ahmed, EI; Boushra, AF; Elsayed, AM; Ibrahim, NA, 2019) |
| "Indomethacin was administered (from 3 days prior with daily oral administration) to mice in which aortic dissection was induced using beta-aminopropionitrile (BAPN) and angiotensin II (Ang II) infusion (2 weeks)." | 5.51 | Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model. ( Aizawa, K; Aoki, H; Imai, Y; Nagai, R; Nishida, N; Suzuki, T; Tomida, S, 2019) |
| "Baicalin was 72% effective versus the reference drug and 80% effective against ethanol-induced ulcers." | 5.46 | Baicalin protects against gastroduodenal ulcers via the modulation of Nrf2 expression: Experimental, biochemical, and histological analyses. ( Meng, X; Yang, D; Zhang, T, 2017) |
| "Small intestinal ulcers are a serious adverse effect commonly occurring in patients taking nonsteroidal anti-inflammatory drugs." | 5.43 | Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Kawauchi, S; Mizuno, S; Nakamura, T; Rikitake, Y; Tanahashi, T, 2016) |
| " Vancomycin (VCM), a poorly absorbed drug, was administered intraduodenally to rats with SIUs." | 5.40 | Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Inoue, J; Kawauchi, S; Miki, I; Mizuno, S; Nakamura, T; Nishikawa, C; Tanahashi, T; Yasui, H, 2014) |
| "Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions." | 5.37 | Curative effect of selenium against indomethacin-induced gastric ulcers in rats. ( Kim, BW; Kim, JH; Kwon, HJ; Nam, SW, 2011) |
| "Inflammation was induced by injection of 0." | 5.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| "Indomethacin treatment significantly decreased cotton pellet implantation induced white blood cell count elevation and immune cells infiltration in epididymal white adipose tissue." | 5.36 | Indomethacin activates peroxisome proliferator-activated receptor γ to improve insulin resistance in cotton pellet granuloma model. ( Chen, W; Cheng, JT; Cheng, KC; Shen, KH; Wu, HT; Yeh, CH, 2010) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 5.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "Gastric ulcer is a source of visceral pain." | 5.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| " In this study, NS-398, a specific COX-2 inhibitor, and indomethacin, a COX-1 and COX-2 inhibitor, were administered 24 h after chloroform dosing to determine their effect on liver injury in Sprague-Dawley rats." | 5.32 | Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. ( Begay, CK; Gandolfi, AJ, 2003) |
| "Indomethacin is a clinically applied nonsteroidal antiphlogistic, and in previous studies in the rat, it has been found to induce an inflammatory reaction in the small intestine characterized by edema and reddening of the intestinal epithelium, ulceration, and dysregulation in the intestinal-epithelial barrier function." | 5.32 | Effect of N-acetylcysteine on microcirculation of mucosa in rat ileum in a model of intestinal inflammation. ( Ruh, J; Schmidt, E; Vogel, F, 2003) |
| "Pre-treatment with indomethacin significantly reduced the protective effect of the extract against HCl/ethanol solution to 31%." | 5.31 | Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats. ( Dimo, T; Dongo, E; Tan, PV, 2000) |
| "Pretreatment with indomethacin, a cyclooxygenase inhibitor, also inhibited the carrageenin-induced responses significantly in normal rats." | 5.31 | Evidence for bradykinin mediation of carrageenin-induced inflammatory pain: a study using kininogen-deficient Brown Norway Katholiek rats. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "Synoviocytes from adjuvant arthritis rats released a higher level of interleukin (IL)-1 and tumor necrosis factor (TNF) than that from the normal, control group." | 5.30 | Effects of indomethacin on secretory function of synoviocytes from adjuvant arthritis rats. ( Chen, MZ; Wang, B, 1998) |
| "A condition similar to preeclampsia was induced by infusing pregnant rats with the nitric oxide synthase inhibitor N G -nitro- L -arginine methyl ester through subcutaneously implanted osmotic minipumps." | 5.30 | The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia. ( Buhimschi, I; Chwalisz, K; Garfield, RE; Liao, QP; Saade, GR; Zlatnik, MG, 1999) |
| "Pretreatment with indomethacin did not result in improved fetal survival." | 5.29 | A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy. ( Gibbs, RS; Heddleston, L; McDuffie, RS, 1993) |
| "Acetic acid colitis was induced 24 hr before enzyme inhibition began." | 5.29 | Effects of cyclooxygenase and lipoxygenase inhibition on eicosanoids and healing of acetic acid colitis in rats. ( Guth, E; Guth, PH; LeDuc, LE; Reedy, T; Su, KC, 1993) |
| "The onset of ocular hypertension occurred within 15 min." | 5.28 | Argon laser-induced ocular hypertension: animal model of ocular inflammation. ( Gherezghiher, T; Koss, MC, 1989) |
| "In rat carrageenin pleurisy, dexamethasone (0." | 5.26 | Comparison of the anti-inflammatory effects of dexamethasone, indomethacin and BW755C on carrageenin-induced pleurisy in rats. ( Mikami, T; Miyasaka, K, 1982) |
| "Oedema was measured after the challenging injection." | 5.26 | Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs. ( Arrigoni-Martelli, E; Bramm, E; Dieppe, PA; Huskisson, EC; Willoughby, DA, 1976) |
| " pylori infection, indomethacin and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed acetic acid ulcers; and 2) whether or not eradication of the bacteria with drugs at specified times after infection prevents the development of mucosal changes, including gastric adenocarcinoma." | 4.81 | [Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. ( Ebata, M; Keto, Y; Okabe, S, 2001) |
| " In this study, PVR was induced in pups in utero by exposure of pregnant dams to indomethacin and hypoxia and cardiac lipids, echocardiographic function and cardiomyocyte mitochondrial function were subsequently examined." | 4.12 | Altered cardiolipin metabolism is associated with cardiac mitochondrial dysfunction in pulmonary vascular remodeled perinatal rat pups. ( Cole, LK; Dolinsky, VW; Hatch, GM; Sparagna, GC, 2022) |
| " The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy." | 4.02 | Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021) |
| " Hence, we investigated whether probiotics can control the onset of this severe condition in a murine model of intestinal inflammation induced by the NSAID, indomethacin." | 4.02 | Probiotic lactobacilli as a promising strategy to ameliorate disorders associated with intestinal inflammation induced by a non-steroidal anti-inflammatory drug. ( Balcells, MF; Cazorla, SI; De Paula, JA; Galdeano, CM; Monteros, MJM; Perdigón, G; Weill, R, 2021) |
| " speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs." | 4.02 | Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021) |
| "In the present study, milnacipran showed anti-nociceptive and anti-inflammatory effects on carrageenan-induced hyperalgesia and inflammation in a dose-dependent manner." | 3.96 | Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress. ( Haddadi, R; Rashtiani, R, 2020) |
| " However, there is lack of evidence that fluvoxamine recruits Hsp70 to affect stress-induced gastric ulcer." | 3.91 | Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70. ( Ardianto, C; Aryani, T; Dinintia, Y; Khotib, J; Nisak, K; Oktavia, R; Rahmadi, M; Ratnasari, A; Shinta, DW, 2019) |
| "The aim of the study was to investigate the effects of four Aronia melanocarpa-based juices in a rat model of indomethacin-induced gastric ulceration." | 3.91 | Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers. ( Denev, P; Eftimov, M; Georgieva, A; Kuzmanov, A; Kuzmanov, K; Kuzmanova, V; Tzaneva, M; Valcheva-Kuzmanova, S, 2019) |
| "The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats." | 3.88 | Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms. ( Chen, H; Lai, X; Li, C; Lin, G; Luo, C; Su, Z; Tan, L; Wang, Y; Xie, J; Zeng, H, 2018) |
| "Indomethacin administration caused weight loss, increased the signs of severe infection and worsened histopathological damage, leading to 100% mortality during CDI." | 3.88 | Indomethacin increases severity of Clostridium difficile infection in mouse model. ( Aronoff, DM; Bergin, IL; Castro-Córdova, P; Gil, F; Kirk, LA; Muñoz-Miralles, J; Paredes-Sabja, D; Trindade, BC, 2018) |
| " Based on previous studies demonstrating the important antioxidant and anti-hyperlipidemic effect of morpholine and 1,4-benzo(x/thi)azine derivatives (A-E), we hereby present the design, synthesis and pharmacological evaluation of novel dual-acting molecules as a therapeutic approach for atherosclerosis." | 3.85 | Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity. ( Katselou, MG; Kourounakis, AP; Matralis, AN, 2017) |
| "In this study, we aimed to investigate the effect of indomethacin and dimethyl sulfoxide (DMSO), well-known antioxidant and anti-inflammatory agents, to heal eye burns induced with hydrofluoric acid in rabbits." | 3.85 | Dimethyl sulfoxide but not indomethacin is efficient for healing in hydrofluoric acid eye burns. ( Altan, S; Oğurtan, Z, 2017) |
| "Group containing indomethacin-loaded nanocapsules (NC) presented lower edema in the right hind paw at 24h after formalin injection than those of the control group (CT) (P<0." | 3.85 | Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules. ( Cioato, SG; Collares, FCM; da Silva Torres, IL; de Freitas, JS; Ferreira, MBC; Genari, B; Guterres, SS; Leitune, VCB; Medeiros, LF; Pohlmann, AR; Samuel, SMW, 2017) |
| ""Unhealed gastric ulcers" were induced using indomethacin following the establishment of acetic-acid-induced chronic gastric ulcers." | 3.85 | Healing and Antisecretory Effects of Aqueous Extract of ( Amang, AP; Emakoua, J; Enow-Orock, GE; Mbah, G; Mezui, C; Nkwengoua, EZ; Siwe, GT; Tan, PV, 2017) |
| "This study investigated the gastroprotective effects of N-acetylcysteine (NAC) against indomethacin-induced gastric ulcer in rats." | 3.85 | N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms. ( Ali, DA; Katary, MA; Soliman, NA; Zineldeen, DH, 2017) |
| " After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days." | 3.85 | Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats. ( Eyoum Bille, B; Kouitcheu Mabeku, LB; Nanfack Nana, B; Nguepi, E; Tchuenteu Tchuenguem, R, 2017) |
| "To examine the effect of koumine, a Gelsemium alkaloid, on two experimental models of rheumatoid arthritis (RA), rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) were administered koumine (0." | 3.83 | Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats. ( Cai, HD; Chen, ZH; Fang, MH; Huang, HH; Su, YP; Xu, Y; Yang, J; Yu, CX; Zeng, YL, 2016) |
| "The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats." | 3.83 | Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata. ( Garuba, T; Ismail, NO; Sabiu, S; Sulyman, AO; Sunmonu, TO, 2016) |
| " The aim was to scientifically evaluate the possible gastroprotective effect and the underlying mechanisms of pogostone against indomethacin-induced gastric ulcer in rats." | 3.83 | The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. ( Chen, HM; Chen, XY; Fu, LD; Huang, XQ; Lai, XP; Liang, YZ; Liu, YH; Su, ZQ; Su, ZR; Xie, JH; Zhang, X; Zhang, ZB; Zheng, YF, 2016) |
| "The analgesic effects on pain-related behaviors following the topical application of hangeshashinto were evaluated in an oral ulcer rat model treated with acetic acid using recently developed methods." | 3.83 | The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model. ( Hattori, T; Hitomi, S; Imai, R; Inenaga, K; Kase, Y; Kubota, K; Omiya, Y; Ono, K; Terawaki, K; Yamaguchi, K, 2016) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 3.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| " Materials and methods Analgesic and anti-inflammatory activities of ISA were evaluated using writhing, hot plate, xylene-induced ear oedema, carrageenan-induced paw oedema and cotton pellets-induced granuloma test, meanwhile the prostaglandin E2 (PGE2) and malondialdehyde (MDA) levels were assessed in the oedema paw tissue." | 3.83 | Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid. ( Dong, K; Sun, JY; Xing, JF; You, CY; You, HS, 2016) |
| " In this study, a series of novel thiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives bearing naproxen was synthesized and evaluated for their in vivo analgesic and anti-inflammatory properties in acute experimental pain and inflammation models." | 3.81 | Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies. ( Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A, 2015) |
| "Cu-Indo gel at lower doses was superior to or at least as effective as its parent substance, indomethacin, in most of the studied parameters of inflammation." | 3.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| " This study investigated the anti-ulcerogenic and antioxidant activities of aqueous extract of Carica papaya seed against indomethacin-induced peptic ulcer in male rats." | 3.81 | Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. ( Adaja, MC; Ajiboye, TO; Oloyede, HO; Salawu, MO, 2015) |
| " The cyclo-oxygenase inhibitor indomethacin partially inhibited knee oedema and allodynia but did not affect the leukocyte influx, myeloperoxidase activity or impaired motion in the kaolin-injected rat." | 3.81 | Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats. ( Camargo, LL; Costa, SK; Denadai-Souza, A; Fernandes, E; Grant, A; Lima, C; Mesquita, FP; Muscará, MN; Schenka, A; Soares, AG; Yshii, LM, 2015) |
| " Antiulcerogenic activity of AcE-NP was also evaluated with an acute gastric ulcer experimental model induced by ethanol and indomethacin." | 3.81 | Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity. ( de Carvalho, JE; Foglio, MA; González-Gómez, A; Jorge, MP; Monteiro, KM; Queiroz, Nde C; Reyes-Ortega, F; San Román, J; Servat-Medina, L; Sousa, IM; Zago, PM, 2015) |
| " Xylene-induced ear edema, carrageenan-induced paw edema and acetic acid-induced vascular permeability test were used to investigate the anti-inflammatory activities of GL in mice." | 3.81 | Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice. ( Li, YX; Ma, L; Niu, Y; Niu, YT; Shi, GJ; Sun, T; Wang, HL; Wu, J; Yu, JQ; Zheng, J, 2015) |
| "To investigate the effects of nilotinib in a rat model of indomethacin-induced enterocolitis." | 3.81 | Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. ( Ataca, P; Borekci, E; Dervis Hakim, G; Karaman, M; Sagol, O; Soyturk, M; Unlu, M; Yilmaz, O, 2015) |
| "To investigate the protective effect of DHEA on indomethacin-induced gastric ulcers in rats." | 3.80 | The impact of dehydroepiandrosterone on indomethacin-induced gastric lesions in rats. ( Alessa, R; Alkhateeb, M; Bayoumy, NM; Bin-Jaliah, I; Eleawa, S; Sakr, HF, 2014) |
| " Inflammation was studied when evoked, either by PDT using a trisulfonated porphyrazine photosensitizer, or lipopolysaccharide (LPS), and inhibited using indomethacin." | 3.80 | Deciphering PDT-induced inflammatory responses using real-time FDG-PET in a mouse tumour model. ( Cauchon, N; Hasséssian, HM; Lecomte, R; Turcotte, E; van Lier, JE, 2014) |
| "To evaluate the renoprotection effects of non-steroidal anti-inflammatory drugs (NSAIDs) in renal ischemia-reperfusion injury (IRI) and the cyclooxygenase (COX)-1/2 blockade association by indomethacin (IMT) in the mice model." | 3.80 | Protective effect of indomethacin in renal ischemia-reperfusion injury in mice. ( Chen, JH; Chen, RJ; Feng, S; Jiang, H; Jin, J; Lin, C; Wu, JY; Zhou, LJ; Zhu, SH, 2014) |
| "Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin." | 3.80 | Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. ( Argaãaraz, GA; Cavalheiro, EA; Graça Naffah-Mazzacoratti, Md; Perosa, SR; Silva, JA; Vieira, MJ, 2014) |
| " Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test." | 3.79 | Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. ( Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA, 2013) |
| " As cold allodynia is frequently observed in individuals experiencing toothache pain, we tested whether mice with DPI demonstrate an aversion to drinking cold liquids using a cold-sucrose consumption test." | 3.79 | Paradoxical surrogate markers of dental injury-induced pain in the mouse. ( Basbaum, AI; Gibbs, JL; Urban, R, 2013) |
| "The aim of this study was to examine the effects of the hyperandrogenic state in dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS), the vascular responses to different vasoactive agents, and the modulatory role of vitamin D3." | 3.79 | Effects of vitamin D3 derivative--calcitriol on pharmacological reactivity of aortic rings in a rodent PCOS model. ( Benko, R; Benyó, Z; Buday, A; Hamar, P; Horvath, EM; Masszi, G; Nadasy, GL; Novak, A; Revesz, C; Ruisanchez, E; Sara, L; Tarszabo, R; Tokes, AM; Varbiro, S, 2013) |
| " The anti-inflammatory activity of 1a-h was investigated by acute carrageenan-induced paw edema in mice using the reference drug indomethacin." | 3.79 | Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties. ( Al-Tabakha, MM; Caproiu, MT; Fahelelbom, KM; Limban, C; Missir, AV; Sadek, B, 2013) |
| " However, the gastroprotective effect of chronic stress was not manifested and there was no aggravation of indomethacin-induced gastric ulceration, either." | 3.79 | Does chronic stress enhance the risk of diseases? ( Filaretova, L; Laszlo, F; Morozova, O; Morschl, E; Zelena, D, 2013) |
| " This study aimed to investigate the effects of hemin, an HO-1 inducer, on indomethacin-induced enteritis in mice." | 3.79 | Hemin ameliorates indomethacin-induced small intestinal injury in mice through the induction of heme oxygenase-1. ( Fukui, A; Handa, O; Harusato, A; Higashimura, Y; Hirai, Y; Ichikawa, H; Kamada, K; Katada, K; Kugai, M; Mizusima, K; Naito, Y; Takagi, T; Tsuji, T; Uchiyama, K; Yagi, N; Yamada, S; Yoriki, H; Yosikawa, T, 2013) |
| "The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol) alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats." | 3.78 | Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. ( Apikoglu-Rabus, S; Cevikbas, U; Izzettin, FV; Okuyan, B; Sancar, M, 2012) |
| "The effects of long-term use of celecoxib, ibuprofen, and indomethacin on types I, II, and III collagen metabolism were evaluated in rat osteoarthritis (OA) model." | 3.78 | The effects of NSAIDs on types I, II, and III collagen metabolism in a rat osteoarthritis model. ( An, H; Jiang, DM; Luo, XJ; Ou, YS; Quan, ZX; Tan, C; Tang, K, 2012) |
| " The analgesic activity was examined against oxytocin-induced dysmenorrhea in mice." | 3.78 | Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. ( Chen, T; Duan, JA; Gu, W; Hua, Y; Jiang, H; Su, S; Tang, Y; Wang, Y; Zhou, W, 2012) |
| "Lysophosphatidic acid (LPA), an initiator of neuropathic pain, causes allodynia." | 3.78 | Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs. ( Kato, A; Ogawa, K; Shinohara, S; Takasu, K; Yoneda, Y, 2012) |
| "Zerumbone (1) showed potent cytoprotective effect against necrotizing agent (HCl) and non-steroidal anti-inflammatory drug (indomethacin) induced gastric ulceration." | 3.78 | Antiulcer principle from Zingiber montanum. ( Al-Amin, M; Hossain, CF; Sultana, GN, 2012) |
| " In all models, URB937 was as effective or more effective than standard analgesic and anti-inflammatory drugs (indomethacin, gabapentin, dexamethasone) and reversed pain-related responses (mechanical hyperalgesia, thermal hyperalgesia, and mechanical allodynia) in a dose-dependent manner." | 3.78 | Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. ( Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R, 2012) |
| "BI prevented the gastric ulceration caused by ethanol and indomethacin treatments." | 3.78 | Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb. ( Bonaldo, J; Dall'oglio, EL; de Sousa Júnior, PT; Gazoni, VF; Lemos, LM; Martins, DT; Martins, TB; Silva, MG; Strada, CL; Tanajura, GH, 2012) |
| "This study investigates the gastroprotective effects of hecogenin, a steroid saponin isolated from Agave sisalana, on experimental models of gastric ulcer." | 3.78 | Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. ( Arcanjo Moura, B; Barbosa Filho, JM; de Almeida Leal, LK; de Barros Viana, GS; de Castro Brito, GA; dos Santos e Silva, G; Fragoso de Freitas, AP; Lopes Souto, A; Rios Vasconcelos, E; Santos Cerqueira, G; Silveira Macedo, D; Souccar, C, 2012) |
| "In a rat model of experimental periodontitis it was investigated whether the presence of the inflammatory disease induced changes in carbachol-induced fluid secretion in parotid glands, by monitoring potassium release." | 3.78 | Influence of experimental periodontitis on cholinergic stimulation of K⁺ release in rat parotid glands. ( Busch, L; Miozza, VA; Sánchez, GA, 2012) |
| "The gastroprotective action of synthetic dipeptides glutamyl-tryptophane (EW), iso-valeroyl-glutamyl-tryptophane (ivEW) and nicotinoyl-glutamyl-tryptophane (nEW) in comparison to melatonin was studied in experiments on male with the model indometacine and starvation stress-induced stomach ulcers." | 3.78 | [Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin]. ( Malinin, VV; Savateeva-Liubimova, TN; Sivak, KV, 2012) |
| "The preventive and healing properties of Croton urucurana bark methanol extract (CUE) were evaluated in experimental models of acute (ethanol and indomethacin) and chronic (acetic acid) gastric ulcers." | 3.78 | Antiulcerogenic effect of Croton urucurana Baillon bark. ( Aparecida Pinto, L; de Cássia Freitas, K; Faloni de Andrade, S; Leite Kassuya, CA; Nazari Formagio, AS; Wolff Cordeiro, K, 2012) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 3.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| " They were subjected to the absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation assays after 30 min." | 3.78 | Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. ( Hamid, HA; Hisam, EE; Mohtaruddin, N; Othman, F; Rofiee, MS; Zakaria, ZA, 2012) |
| "In this rat model of gastrointestinal reflux, indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma." | 3.78 | Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ( Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2012) |
| "This study sought to determine the effect of combined treatment of hypoxia plus indomethacin on pulmonary vascular remodeling in fetal rats." | 3.77 | Fetal pulmonary vascular remodeling in a rat model induced by hypoxia and indomethacin. ( Du, LZ; Gu, WZ; Li, RY; Wu, XL; Xu, XF, 2011) |
| "In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin." | 3.77 | A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis. ( Nagar, S; Rasool, M; Sabina, EP, 2011) |
| "The present study aimed to investigate the effects of indomethacine, montelukast and methylprednisolone in management of experimental otitis media with effusion." | 3.77 | The effects of methylprednisolone, montelukast and indomethacine in experimental otitis media with effusion. ( Aynali, G; Başpinar, S; Gümüş, S; Karahan, N; Tüz, M; Yariktaş, M; Yasan, H, 2011) |
| " Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice." | 3.77 | Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011) |
| " Subsequently, its protective effect in indomethacin and iodoacetamide induced colitis in rats (45, 90, 180, 270 mg/kg) and acetic acid induced colitis in mice (65, 130, 250, 500 mg/kg) was assessed." | 3.77 | Protective effect of aqueous extract of Bombax malabaricum DC on experimental models of inflammatory bowel disease in rats and mice. ( Jagtap, AG; Niphadkar, PV; Phadke, AS, 2011) |
| " Acute gastric ulcer was induced using absolute ethanol, HCl/ethanol and indomethacin." | 3.77 | Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae). ( Caldas, GF; da Costa, JG; da Nóbrega, RF; da Silva, JB; do Amaral Costa, IM; Rodrigues, FF; Wanderley, AG, 2011) |
| "The antinociceptive effect of MCO was evaluated using several experimental pain models, including thermal nociception methods, such as the tail immersion and the hotplate tests, as well as chemical nociception induced by intraperitoneal acetic acid and subplantar formalin administration in mice." | 3.77 | Antinociceptive and hypnotic properties of Celastrus orbiculatus. ( Cha, DS; Jeon, H; Park, HJ, 2011) |
| "The gastro-protective and antioxidant effects of methanol extract of Ficus asperifolia bark on indomethacin induced gastric ulcer were investigated in male rats." | 3.77 | Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats. ( Bolarinwa, AF; Oyeyemi, WA; Raji, Y; Shittu, ST, 2011) |
| " The present study evaluated the effects of progesterone and its active metabolite, allopregnanolone against PTX-induced seizures, brain lipid peroxidation and DNA fragmentation in male mice." | 3.76 | Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice. ( Arora, SK; Chakrabarti, A; Hota, D; Khanduja, KL; Prakash, A; Singh, S, 2010) |
| "Injection of acetic acid (1% and 3%) induced pain behaviors and bladder overactivity proportional to the concentration." | 3.76 | Behavioral and urological evaluation of a testicular pain model. ( Tanahashi, M; Uchida, W; Yoshioka, K, 2010) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of acute gout and inflammation." | 3.76 | Acemetacin antinociceptive mechanism is not related to NO or K+ channel pathways. ( Castañeda-Hernández, G; Chávez-Piña, AE; Gil-Flores, M; Ortiz, MI, 2010) |
| ") were assessed using acetic acid-induced vascular permeability, carrageenan-induced paw edema, and croton oil-induced ear edema." | 3.76 | The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo. ( Cho, YB; Hur, J; Jung, I; Jung, KC; Kang, JY; Kang, M; Kim, KS; Kim, SH; Lee, JD; Lee, JH; Park, DS; Yoo, MC, 2010) |
| ") significantly decreased ethanol- and indomethacin-induced gastric ulcer compared with the vehicle-treated (control) group." | 3.76 | Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. ( Hara, H; Kakino, M; Ogawa, K; Oyagi, A, 2010) |
| "Minocycline and a non-steroidal anti-inflammatory drug (NSAID) indomethacin, have anti-inflammatory activities and are both used in the management of rheumatoid arthritis." | 3.76 | Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis. ( Abu-Ghefreh, AA; Masocha, W, 2010) |
| "The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model." | 3.76 | Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Hassarajani, SA; Maity, B; Narayan, G, 2010) |
| "Administration of indomethacin (10mg/kg), paracetamol (150 mg/kg) and/or different doses of earthworm extract (EE) (50, 100 and 200mg/kg) reduced and restored to normal conditions in a dose-dependent manner of histamine and turpentine induced inflammation, and Brewer's yeast induced pyretic in rats." | 3.75 | Anti-inflammatory and anti-pyretic activities of earthworm extract-Lampito mauritii (Kinberg). ( Balamurugan, M; Cooper, EL; Parthasarathi, K; Ranganathan, LS, 2009) |
| "To evaluate anti-ulcer effect of estrogen and luteinising hormone (LH) on indomethacin-induced ulcer model in female rats." | 3.75 | Role of alpha-2 adrenergic receptors in anti-ulcer effect mechanism of estrogen and luteinising hormone on rats. ( Albayrak, F; Borekci, B; Cadirci, E; Halici, Z; Karaca, M; Kumtepe, Y; Polat, B; Suleyman, H, 2009) |
| " Pretreatment with Cyclea peltata extract provided significant protection against the peptic ulceration caused by ethanol administered individually, or in combination with indomethacin." | 3.75 | Gastric antisecretory and antiulcer activities of Cyclea peltata (Lam.) Hook. f. & Thoms. in rats. ( Anuja, GI; Latha, PG; Pradeep, S; Rajasekharan, S; Shine, VJ; Shyamal, S; Sini, S; Suja, SR, 2009) |
| " For this study, ethanol- and indomethacin-induced gastric ulcer models in mice and histopathological assessment were used." | 3.75 | Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action. ( de Carvalho, AM; de Sousa, DP; de Sousa, FC; Macêdo, DS; Moura, BA; Neto, MR; Rocha, NF; Silva, MI; Tomé, Ada R; Vasconcelos, SM; Viana, GS, 2009) |
| " The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats." | 3.75 | Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009) |
| "To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers." | 3.75 | EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009) |
| " Next, intestinal inflammation was induced by subcutaneous injections of indomethacin to rats." | 3.74 | Enzyme-modified cheese exerts inhibitory effects on allergen permeation in rats suffering from indomethacin-induced intestinal inflammation. ( Isobe, N; Oda, M; Suzuki, M; Tanabe, S, 2008) |
| "To observe and compare the effect of taurine on contractions of aortic rings isolated from normal (NC) and insulin resistance (IR) Sprague-Dawley rats, and to explore its underlying mechanism(s)." | 3.74 | Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed. ( Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M, 2008) |
| " To determine the beneficial effects of statins on the airway hyperresponsiveness, a characteristic feature of allergic bronchial asthma, the effect of systemic treatment with lovastatin on antigen-induced bronchial smooth muscle hyperresponsiveness was investigated in mice." | 3.74 | Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice. ( Chiba, Y; Misawa, M; Sato, S, 2008) |
| " In the present study, the effect of withaferin A, a steroidal lactone was investigated on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin." | 3.74 | Inhibition of monosodium urate crystal-induced inflammation by withaferin A. ( Chandal, S; Rasool, MK; Sabina, EP, 2008) |
| "In this study the effects of compound B1, bis(3-aryl-3-oxo-propyl)methylamine hydrochloride, and an anti-inflammatory drug, indomethacin, were tested by carrageenan-induced paw edema and cotton pellet granuloma tests, for effects on acute and chronic phases of inflammation, respectively." | 3.74 | Anti-inflammatory activity of bis(3-aryl-3-oxo-propyl)methylamine hydrochloride in rat. ( Alkan, M; Gocer, F; Gul, HI; Gul, M; Suleyman, H, 2007) |
| "Rats receiving intracolonic administration of indomethacin develop longitudinal ulcers on the mesenteric side of the small intestine that are similar to those seen in the acute phase of Crohn's disease." | 3.74 | Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats. ( Haruma, K; Iida, M; Koga, H; Shimizu, K, 2007) |
| "APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties." | 3.74 | Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Bhattacharya, S; Chattopadhyay, S, 2007) |
| "The healing activity of the methanol extract of the spice rampatri, Myristica malabarica, (RM) and omeprazole against indometacin-induced stomach ulceration has been studied in a mouse model." | 3.74 | Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Maity, B, 2007) |
| "The healing activity of malabaricone B and malabaricone C, the major antioxidant constituents of the spice Myristica malabarica against the indomethacin-induced gastric ulceration in mice has been studied." | 3.74 | Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Guha, RK, 2008) |
| "To investigate the protective effects of sildenafil citrate (SC) on indomethacin-induced gastric ulcer in a rat model." | 3.74 | The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. ( Atamanalap, SS; Aydinli, B; Başoğlu, M; Gündoğdu, C; Gürsan, N; Kiziltunç, A; Oren, D; Oztürk, G; Polat, KY; Süleyman, H; Yildirgan, MI, 2007) |
| "Early postnatal steroids and indomethacin in combination have been shown to increase the risk of spontaneous intestinal perforation (SIP) in infants with extremely low birth weight (ELBW), but the mechanism behind this synergistic effect is unknown." | 3.74 | A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin. ( Aschner, JL; Gaston, BM; Gordon, PV; Herman, AC; Laubach, VE; Marcinkiewicz, M, 2007) |
| "Results of these studies demonstrate that provision of additional NO substrate in the form of L-arginine incites prostaglandin-dependent secretory diarrhea and does not promote epithelial defense or barrier function of C." | 3.74 | Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. ( Coccaro, MR; Foster, DM; Gookin, JL; Stauffer, SH, 2008) |
| "During the early stages of indomethacin-induced ileitis, epithelial barrier damage and abnormal bacterial infiltration into the mucosa occurred in conjunction with initial redistribution of CD103+DC." | 3.74 | Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage. ( Jury, J; Perdue, MH; Porras, M; Silva, MA; Vergara, P, 2008) |
| "The effect of irsogladine maleate, a widely used antiulcer drug in Japan, on indomethacin-induced small intestinal lesions was examined in rats." | 3.74 | Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats. ( Amagase, K; Hatazawa, R; Kamei, K; Kato, N; Kubo, Y; Takeuchi, K, 2008) |
| "Results of this study indicate that tacrolimus has an important anti-inflammatory property, showing not only inhibition of pro-inflammatory mediators release, but also inhibition of activated leukocyte infiltration into the site of inflammation." | 3.74 | Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch. ( de Liz, R; Fröde, TS; Medeiros, YS; Vigil, SV, 2008) |
| " It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects." | 3.74 | Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice. ( Itabashi, T; Kawai, K; Takido, M; Yasukawa, K, 2008) |
| "Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels." | 3.74 | Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Bhattacharya, S; Chattopadhyay, S, 2008) |
| " However, the role of MMPs in indomethacin-induced gastric ulcer and its healing process are not clearly understood." | 3.73 | Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. ( Banerjee, A; Ganguly, K; Kundu, P; Maity, P; Sharma, AV; Swarnakar, S, 2005) |
| " Since compounds with cytoprotective and antioxidant effects can improve healing of gastroduodenal ulcer induced by noxious agents, this work investigated the healing effect of D- 002 on acute and chronic gastric ulcers induced with indomethacin and acetic acid, respectively, in rats." | 3.73 | Therapeutic effect of D-002 (abexol) on gastric ulcer induced experimentally in rats. ( Arruzazabala, L; Carbajal, D; Más, R; Molina, V, 2005) |
| "Oral administration for 6 days of 100 mg/kg MMK-1, an agonist peptide selective for the FPRL1 receptor, suppressed alopecia induced by the anticancer drug etoposide in neonatal rats." | 3.73 | Orally administered FPRL1 receptor agonist peptide MMK-1 inhibits etoposide-induced alopecia by a mechanism different from intraperitoneally administered MMK-1. ( Tsuruki, T; Yoshikawa, M, 2006) |
| "The objective of this study was to trigger the formation of rat abdominal aortic aneurysm by applying calcium chloride periarterially and then to detect the degree of prevention of aneurysm occurrence by oral introduction of indomethacin in some of the rats." | 3.73 | Influence of indomethacin in the rat aneurysm model. ( Erdoğan, F; Erkut, B; Karapolat, S; Koçak, H; Unlu, Y, 2006) |
| " Following the unilateral intraplantar injection of BmK venom into rat hind paw, it was found: 1) BmK venom induced an edematogenic response, spontaneous pain and pain hypersensitivity in a dose-dependent manner; 2) the paw edema and flare were induced rapidly and restricted at the injected paw for about 24-48 h; 3) the monophasic tonic spontaneous pain manifested as continuous paw flinching and lifting/licking of the injected paw and lasted for more than 2 h; 4) the detectable thermal hypersensitivity to radiant heat stimuli was just at the injected side for about 72-96 h; 5) the mechanical hypersensitivity to von Frey filaments was evoked surprisingly to be the bilateral and mirror-like for about 2-3 weeks; 6) morphine, indomethacin and bupivacaine could suppress BmK venom-induced pain responses with different intensity and time courses." | 3.73 | Rat pain-related responses induced by experimental scorpion BmK sting. ( Bai, ZT; Chai, ZF; Ji, YH; Liu, T; Pang, XY, 2006) |
| " L-carnitine significantly prevented gastric ulcerogenesis induced by indomethacin and decreased the ulcer index macroscopically and histopathologically." | 3.73 | Gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal injury in rats: a preliminary study. ( Altaner, S; Dokmeci, D; Erkin, B; Turan, FN, 2006) |
| "In the present study, we evaluated the consequences of prostaglandin E(2) (PGE(2)) or indomethacin injection into the spinal cord, on a model of peripheral inflammatory edema." | 3.72 | A spinal mechanism for the peripheral anti-inflammatory action of indomethacin. ( Daher, JB; Tonussi, CR, 2003) |
| " Indomethacin abolished the gross mucosal protective effect by 1% AA pretreatment in 8% AA-derived colitis in normal rats while the NS398 had no effect." | 3.72 | Acetic acid-derived prostaglandin-dependent colonic adaptive cytoprotection is preserved in chronic colitis: role of cyclo-oxygenase. ( Asama, T; Chisato, N; Kasai, S; Kono, T; Ohara, K; Yoneda, M, 2003) |
| "In our study, the effects of the compound 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride (C1) and also an anti-inflammatory drug, indomethacin, tested by carrageenan-induced paw edema and cotton pellet granuloma tests, for their effects on acute and chronic phases of inflammation, respectively." | 3.72 | Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride. ( Asoglu, M; Gul, HI; Suleyman, H, 2003) |
| "The effects of beta-cyclodextrin (betaCD) inclusion complexation on the ability of violacein to prevent gastric ulceration in mice were studied." | 3.72 | Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin. ( Almeida, AB; Brito, AR; De Azevedo, MB; Durán, N; Haun, M; Justo, GZ; Melo, PS, 2003) |
| "We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation." | 3.72 | Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003) |
| "Using automatic erythrocyte aggregometer type MA-1 (Myrenne gmbh, Germany), we investigated the hypothesis that therapeutic effectiveness of quinapril--angiotensin converting enzyme inhibitor (ACEI)--in the treatment of hypertension would correlate with improvement of red blood cell (RBC) aggregability." | 3.72 | Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension. ( Adamek-Guzik, T; Korbut, R; Korbut, RA; Madej, J, 2003) |
| "This investigation was undertaken to study the effect of methimazole (MMI) on gastric acid secretion and stress and chemically induced gastric ulcer in rats." | 3.72 | Methimazole prevents stress and chemical induced gastropathy in rats. ( Al Moutaery, A, 2003) |
| " We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice." | 3.72 | Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004) |
| "Rats were injected with LPS to induce uveitis and divided into three groups: treated with LPS only, LPS + dexamethasone and LPS + indomethacin, respectively." | 3.72 | The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats. ( Bajor, T; Farkas, A; Hrabák, A; Szabó, A; Vámos, R, 2004) |
| "5-2 mg per ear), reduced ear edema induced by arachidonic acid (AA) and phorbol myristate acetate (PMA, ED50 = 1." | 3.72 | In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG). ( Delgado, R; Delporte, C; García, D; Garrido, G; González, D; Lemus, Y; Lodeiro, L; Núñez-Sellés, AJ; Quintero, G, 2004) |
| "The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours)." | 3.72 | Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin. ( Antônio, MA; Bighetti, AE; Carvalho, JE; Rosaneli, CF; Sgarbieri, VC, 2004) |
| " Indomethacin induced gastritis but without atrophy, and short-term vitamin deficiency failed to induce chronic gastritis and gastric atrophy." | 3.72 | Chronic gastritis rat model and role of inducing factors. ( Huang, HD; Si, JM; Xiang, Z, 2004) |
| "The role of nitric oxide (NO) in the antinociceptive effect of indomethacin was assessed in the pain-induced functional impairment model in the rat (PIFIR model), a model of inflammatory and chronic pain similar to that observed in clinical gout." | 3.72 | Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat. ( Déciga-Campos, M; Díaz-Reval, MI; González-Trujano, ME; López-Muñoz, FJ; Ventura-Martínez, R, 2004) |
| " Concerning the gastric effects, lavender oil, linalool and linalyl acetate oral administration protected against acute ethanol-induced gastric ulcers but did not prevent indomethacin-induced lesions indicating no interference with arachidonic acid metabolic cascade." | 3.72 | Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil. ( Ballabeni, V; Barocelli, E; Bianchi, A; Bruni, R; Calcina, F; Chiavarini, M; Impicciatore, M, 2004) |
| "The acetone soluble fraction from a crude methanol extract of Stryphnodendron adstringens stem bark (AFSAB) was evaluated in acute (ethanol, indomethacin and hypothermic restraint-stress) and chronic (acetic acid) models of gastric ulceration and on basal and bethanechol-stimulated gastric acid secretion in rats." | 3.71 | The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats. ( Lima, JC; Martins, DT; Rao, VS, 2002) |
| " Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited DMBA-induced inflammation and local immunosuppression." | 3.71 | Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2. ( Horio, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Tanaka, K; Urade, Y, 2001) |
| "To determine the natural history of lung vascular remodeling and cardiac changes in the rat model of persistent pulmonary hypertension syndrome (PPHN) of the newborn, we studied fetal rats subjected to maternal indomethacin administration initiated on day 19 of gestation and continued for 2, 3, or 4 days." | 3.71 | Progressive lung and cardiac changes associated with pulmonary hypertension in the fetal rat. ( Belik, J; Fabris, VE; Pato, MD, 2001) |
| " Ileitis was induced in Sprague-Dawley rats by two injections of indomethacin (7." | 3.71 | Role of intercellular adhesion molecule 1 in indomethacin-induced ileitis. ( Bruewer, M; Cerwinka, WH; Granger, DN; Grisham, MB; Krieglstein, CF; Laroux, FS; Russell, JM; Salter, JW; Schuermann, G, 2001) |
| " Pre-treatment with the extract (100, 200 and 400 mg/kg) produced a significant and dose-dependent inhibition to the acute gastric ulcers induced by phenylbutazone, indomethacin, 0." | 3.71 | Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats. ( Al-Attas, A; Chan, K; Chen, HB; Islam, MW; Ismail, A; Liu, XM; Radhakrishnan, R; Zakaria, MN, 2001) |
| " Three models of acute gastric damage (ethanol, hemorrhagic shock, and indomethacin) were examined and treatment was also carried out with the antiulcer drugs omeprazole, ranitidine, and misoprostol, to show the advantages of this histomorphometric approach." | 3.71 | Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage. ( Blandizzi, C; Del Tacca, M; Gherardi, G; Lazzeri, G; Lenzi, P; Natale, G; Pellegrini, A, 2001) |
| "In this study, using rat carrageenin-induced pleurisy, we found that treatment of rats with either indomethacin or NS-398 suppressed the pleurisy at 2 h but significantly exacerbated this reaction at 48 h." | 3.71 | Role of cyclopentenone prostaglandins in rat carrageenin pleurisy. ( Di Rosa, M; Ialenti, A; Ianaro, A; Maffia, P; Pisano, B, 2001) |
| " These acid-induced writhing reactions were significantly attenuated by capsazepine, a VR1 receptor-specific antagonist, but the phenylbenzoquinone-induced one was not, suggesting that the acids but not phenylbenzoquinone activate the VR1 receptor, which is involved in polymodal pain perception." | 3.71 | Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "We investigated the effect of diacerein, an antiosteoarthritic agent, and its metabolite, rhein, on the production of reactive oxygen species (ROS) from neutrophils as well as the protective effect of diacerein on indomethacin-induced gastric ulceration and its protection mechanism." | 3.71 | Effects of diacerein on indomethacin-induced gastric ulceration. ( Ohmori, K; Tamura, T; Yokoyama, T, 2001) |
| " The acute gastric ulcer models used were pylorus ligation, indomethacin, ethanol and histamine induced acute gastric ulcers." | 3.71 | Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. ( Abraham, BK; Asad, M; Koumaravelou, K; Ramaswamy, S; Shewade, DG; Vasu, S, 2001) |
| " The antiinflammatory activity of synthetic cannabinoid nabilone in the rat model of carrageenan-induced acute hindpaw inflammation was compared with that of the endocannabinoid palmitoylethanolamide and the nonsteroidal antiinflammatory drug indomethacin." | 3.71 | Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. ( Colleoni, M; Conti, S; Costa, B; Giagnoni, G; Parolaro, D, 2002) |
| "To investigate the relationship between cytokine IL-6, IL-1, TNF-alpha and experimental cancer cachexia as well as observe the effect of indomethacin on the cachectic mice." | 3.71 | [Cytokines in experimental cancer cachexia]. ( Li, T; Liu, A; Niu, Q, 2001) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 3.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| " The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay." | 3.70 | Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole. ( Barreiro, EJ; Fraga, CA; Lages, AS; Miranda, AL; Silva, KC, 1998) |
| " In this work, ointments made from the same extract and three different excipients (vaseline, lanoline and shea butter (crude and refined)) have been prepared and tested by the method of the croton oil inhibited ear oedema." | 3.70 | [Inflammatory ointment from shea butter and hydro-alcoholic extract of Khaya senegalensis barks (Cailcederat)]. ( Ahodikpe, D; Dieng, M; Diop, AB; Lo, I; Ngom, S; Thioune, O, 2000) |
| " Inhibition of prostaglandin synthesis by traditional NSAIDs such as indomethacin and diclofenac which non-selectively inhibit both PGHS-1 and PGHS-2, causes gastric and intestinal ulceration and delays gastric ulcer healing in chronic models." | 3.70 | Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. ( Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T, 1998) |
| " The objective of this study was to assess the effect of lactulose (Lac) and neomycin (Neo), both of which are used clinically for changing or reducing intestinal flora, on leukocyte-endothelial cell interaction in an indomethacin (Indo)-induced long-lasting ileitis in Sprague-Dawley rats." | 3.70 | Lactulose and neomycin attenuate leukocyte-endothelial cell adhesion in an animal model of inflammatory bowel disease. ( Arndt, H; Palitzsch, KD; Schölmerich, J, 1998) |
| " When the eyes were treated with histamine, a complement C5a analogue peptide and hydrogen peroxide, typical signs of uveitis were produced." | 3.70 | Arterially perfused eye model of uveitis. ( Sanderson, SD; Shiels, IA; Taylor, SM, 1999) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "The healing of experimental gastric ulcers induced in rats is consistently delayed upon chronic treatment with indomethacin." | 3.70 | A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers. ( Amagase, K; Okabe, S, 1999) |
| " Our aim is to determine the antiinflammatory activity of deferiprone, an oral iron chelator, in experimental colitis and gastritis." | 3.70 | Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats. ( Ablin, J; Karmeli, F; Okon, E; Rachmilewitz, D; Shalev, O, 1999) |
| " The topical anti-inflammatory effect of the chloroform extract from Achillea ageratum (Asteraceae) and of stigmasterol and beta-sitosterol, isolated of this extract has been evaluated, against to 12-0-tetradecanoylphorbol acetate (TPA)-induced mouse ear edema, using simple (acute model) and multiple applications (chronic model) of the phlogistic agent." | 3.70 | Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models. ( Fernández, MA; García, MD; Gómez, MA; Sáenz, MT, 1999) |
| "Nimesulide significantly decreased the extent of colitis induced by acetic acid." | 3.70 | Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats. ( Cohen, P; Karmeli, F; Rachmilewitz, D, 2000) |
| " Treatment of -/- pups with indomethacin from day 1 prevented growth retardation and 10% treated for 3 weeks survived, although as adults they exhibited severe polyuria (10 ml/day), extreme hydronephrosis, low plasma potassium, high blood pH, hypercalciuria, and proteinuria." | 3.70 | Uncompensated polyuria in a mouse model of Bartter's syndrome. ( Chernavvsky, DR; Gitelman, HJ; Gomez, RA; Igarashi, P; Smithies, O; Takahashi, N, 2000) |
| " In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection." | 3.70 | The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000) |
| "Studies were undertaken on the effect of a crude (TC) and an alkaloid fraction (TA) of the leaf extracts of Tylophora conspicua on indomethacin-induced gastric ulceration and gastric acid secretion in male albino rats." | 3.70 | Antiulcerogenic effects of Tylophora conspicua in male rats. ( Adesanwo, JK; Hammed, AI; Ogunwande, IA; Raji, Y, 2000) |
| " Using an animal model of diabetes (alloxan-induced hyperglycaemia in mice), a model of gastric ulcer (indomethacin-induced gastric lesion in rats), and a model of bronchial asthma (ovalbumin-induced allergic bronchospasm in guinea pigs), a potential therapeutic effect was tested in known antioxidant drugs (alpha-tocopherol, ubiquinone), the thio-compound mesna, and drugs with a possible antioxidant effect (substances derived from the ergoline structure: 6-hydroxynicotinic acid and 4-hydroxypyridine)." | 3.70 | Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm). ( Grossmann, V; Stetinová, V, 2000) |
| "A series of 2-substituted- and 2,3-disubstituted-4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1H- pyrroles was synthesized and found to be active in the rat adjuvant arthritis model of inflammation." | 3.69 | Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR. ( Galbraith, W; Gans-Brangs, K; Grubb, M; Hewes, WE; Jaffee, B; Kenney, JP; Kerr, J; Wilkerson, WW; Wong, N, 1994) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 3.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| "The influence of (+/-)-verapamil and hydralazine on stress- and various chemically-induced gastric ulcers in rats together with their influence on various biochemical parameters which affect the development of the induced ulcers was examined." | 3.69 | Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats. ( al-Bekairi, AM; al-Rajhi, AM; Tariq, M, 1994) |
| "Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice." | 3.69 | Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. ( Chang, LC; Kuo, SC; Raung, SL; Wang, JP, 1995) |
| " Neither indomethacin nor aspirin showed any effect in preventing osteoarthritis progression." | 3.69 | An experimental model of osteoarthritis in rabbit. ( Chang, DM; Chang, ML; Chen, CM; Chu, SJ; Hsu, CM; Kuo, SY, 1994) |
| "To examine the effect of indomethacin, a cyclooxygenase (CO) inhibitor, on laser-induced subretinal neovascularization (SRN) in the monkey." | 3.69 | Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate. ( Hinton, DR; Murphy, TL; Nassaralla, J; Oganesian, A; Ryan, SJ; Sakamoto, T; Soriano, D; Spee, C, 1995) |
| " The anorexia of indomethacin-induced ulcerative ileitis was compared with that of the well-known anorexia of total parenteral nutrition (TPN)." | 3.69 | Mode of food intake reduction in Lewis rats with indomethacin-induced ulcerative ileitis. ( Holtzapple, PG; Levine, RA; Meguid, MM; Nandi, J; Oler, A; Opara, EI; Veerabagu, MP, 1996) |
| "We found indomethacin aggravates healed gastric ulcers (ulcer relapse) in rats." | 3.69 | Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. ( Asano, S; Inada, I; Maeda, R; Murakami, I; Sato, F; Satoh, H; Shino, A, 1997) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 3.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| "The interaction between renal prostaglandins and atrial natriuretic factor (ANF) for the regulation of renal hemodynamic and excretory function was examined in conscious dogs with arteriovenous fistula and chronic compensated high-output heart failure (n = 6)." | 3.69 | Indomethacin attenuates the renal actions of atrial natriuretic factor in dogs with chronic heart failure. ( Freeman, RH; Habibullah, AA; Simmons, JC; Villarreal, D, 1997) |
| "Immunohistological staining was done using the antibodies for the proliferating cell nuclear antigen prolyl 4-hydroxylase and alpha-smooth muscle actin in acetic acid induced gastric ulcers in rats." | 3.69 | Kinetics of fibroblasts in ulcer healing in rats: interference with indomethacin. ( Arisawa, T; Asai, J; Goto, H; Hase, S; Hayakawa, T; Hirose, Y; Niwa, Y; Tsukamoto, Y, 1997) |
| " Studies were conducted under control conditions and in the presence of four inhibitors of potential mediators of the reactive hyperemia response: the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (30 microM), the adenosine antagonist 8-(p-sulfophenyl)theophylline (50 microM), the K+ cyclic adenosine triphosphate-dependent channel antagonist glibenclamide (10 microM), and the cyclooxygenase inhibitor indomethacin (10 microM)." | 3.69 | Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. ( Dumont, L; Fontaine, E; Jasmin, G; Véronneau, M; Viau, S, 1997) |
| "To investigate changes in regional blood flows (RBF) and vascular porosity during the early phase of the autologous collagen II induced arthritis model (CIA) in rats and the possible influence of indomethacin and nitric oxide (NO) synthase on these variables." | 3.69 | Changes in vascular porosity and joint blood flow during development of collagen induced arthritis in the rat. Modulation by indomethacin and L-NAME. ( Andersson, SE; Ekström, GM, 1997) |
| "The role of indomethacin-induced peptic ulceration in gastric acid secretion was investigated using albino rats of Wistar strain in early, mid and late pregnancy." | 3.68 | Role of indomethacin-induced peptic ulceration in gastric acid secretion in pregnant rats. ( Bolarinwa, Y; Evbuomwan, MI, 1993) |
| "The effects of 4-week indomethacin administration (1mg/kg/day, orally) on gastrin cell (G-cell), somatostatin cell (D-cell) and prostaglandin E2 (PGE2) of gastric mucosa were examined in pyloric stenosis rats." | 3.68 | [Effect of indomethacin on endocrine kinetics of the stomach in experimental pyloric stenosis model]. ( Omura, N, 1993) |
| "The anti-asthmatic effects of CS-518 (sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate) , a specific thromboxane A2 (TXA2) synthase inhibitor, were investigated in the ovalbumin-sensitized guinea pig asthmatic model." | 3.68 | Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response. ( Iizuka, Y; Itoh, K; Mukaiyama, O; Satoh, Y; Terada, A; Yamaguchi, T, 1993) |
| " Local administration of anti-inflammatory drugs such as dexamethasone, indomethacin, or a PLA2 inhibitor such as p-bromophenacyl bromide significantly inhibited exudate volume, cellular influx, granuloma formation, exudate PGE2 levels and PLA2 activity, to varying degrees." | 3.68 | Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation. ( Moreno, JJ, 1993) |
| "The antiinflammatory activity of a new 14-membered macrolide antibiotic, roxithromycin, was evaluated in various rat models including carrageenan- and poly-L-arginine-induced hind-paw oedema, croton oil inflamed ear assay and polyester sponge granuloma." | 3.68 | Macrolide antibiotics as antiinflammatory agents: roxithromycin in an unexpected role. ( Agen, C; Blandizzi, C; Costa, M; Danesi, R; Del Tacca, M; Favini, P; Stacchini, B, 1993) |
| "We have tested the action of cloprostenol a relatively stable analogue of PGF2 alpha in experimentally induced gastric ulcer in rats by contention stress or indomethacin." | 3.68 | Influence of cloprostenol in the experimentally induced ulcer in rats. ( Adomnicăi, M; Dobrescu, G; Nechifor, M; Negru, A; Neughebauer, BI, 1992) |
| "The role of histamine in neutrophil infiltration and vascular permeability response in carrageenin air pouch inflammation in rats was examined." | 3.68 | Downward regulation of neutrophil infiltration by endogenous histamine without affecting vascular permeability responses in air-pouch-type carrageenin inflammation in rats. ( Hirasawa, N; Mue, S; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1991) |
| " Lysosomal enzymes such as acid phosphatase, beta-glucuronidase and succinate dehydrogenase are known to be liberated during the maturation of mononuclear phagocytes to epithelioid cell granulomas." | 3.68 | Histochemical analysis of experimental granulomatous uveitis. ( Biswas, J; Kristeva, M; Pararajasegaram, G; Rao, NA; Sevanian, A, 1991) |
| "Indomethacin lessens edema after repetitive cerebral ischemia, suggesting that elevations of cyclooxygenase products are responsible, at least in part, for severe brain edema following repetitive ischemia." | 3.68 | Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. ( Betz, AL; Deluga, KS; Plötz, FB, 1991) |
| "The effects of indomethacin on central nervous system abnormalities in rabbits with experimental pneumococcal meningitis were studied." | 3.68 | Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits. ( Sande, MA; Täuber, MG; Tureen, JH, 1991) |
| "To investigate the role of interleukin 6 (IL-6) in adjuvant-induced arthritis, serum from adjuvant-immunized Lewis rats treated with cyclosporin, indomethacin, or saline was evaluated for IL-6 activity." | 3.68 | Interleukin-6 serum levels correlate with footpad swelling in adjuvant-induced arthritic Lewis rats treated with cyclosporin A or indomethacin. ( Gaarde, WA; Leisten, JC; Scholz, W, 1990) |
| "The long term effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis in mice were tested under two different treatment protocols." | 3.68 | Effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis of mice. ( Cannon, GW; Cole, BC; Griffiths, MM; McCall, S; Radov, LA; Ward, JR, 1990) |
| " Of the 21 compounds prepared, two were found to be one-tenth as potent as indomethacin in the pleurisy model and one compound was tested and found to be weakly active in the adjuvant arthritis model." | 3.67 | Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives. ( Sancilio, LF; Sleevi, MC; Walsh, DA, 1984) |
| "Lithium chloride was evaluated as a potential protective agent against ethanol-induced hemorrhagic gastritis in rats." | 3.67 | Lithium chloride: protective and antisecretory properties in rats. ( Boedeker, B; Hickey, TM; Johnson, LF; Wilkinson, DS; Wong, RK, 1984) |
| "The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats." | 3.67 | The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984) |
| "The pathogenesis of monocrotaline-induced pulmonary hypertension is not clear." | 3.67 | Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension. ( Kanisawa, M; Kato, T; Kitamura, H, 1989) |
| "The effects of indomethacin on antigen induced arthritis in rabbits have been investigated." | 3.67 | Effect of indomethacin on swelling, lymphocyte influx, and cartilage proteoglycan depletion in experimental arthritis. ( Edwards, JC; Henderson, B; Higgs, GA; Pettipher, ER, 1989) |
| "Healing of duodenal ulcers induced by indomethacin + histamine was investigated in rats." | 3.67 | Healing process of duodenal ulcers induced by indomethacin plus histamine in rats. ( Niida, H; Okabe, S; Okada, M; Takeuchi, K, 1989) |
| "Previous studies have shown that indomethacin administered during the early phase of experimental myocarditis may exacerbate the disease process." | 3.67 | Effect of indomethacin in the late phase of coxsackievirus myocarditis in a murine model. ( Khatib, G; Khatib, R; Kloner, R; Rezkalla, S; Smith, F; Sowers, J; Walsh, M, 1988) |
| "In anesthetized dogs ethchlorvynol (ECV, 9 mg/kg) was selectively administered into the right pulmonary circulation to produce unilateral acute lung injury (ALI) characterized by nonhydrostatic pulmonary edema and systemic hypoxemia." | 3.67 | Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs. ( Dahms, TE; Lonigro, AJ; Sprague, RS; Stephenson, AH, 1986) |
| "The automated system for measuring canine paw pressure is a very useful tool for the evaluation of nonsteroid antiinflammatory drugs such as indomethacin and ibuprofen in the dog synovitis model." | 3.67 | An automated microcomputer-based system for determining canine paw pressure quantitatively in the dog synovitis model. ( Brunner, TR; Carlson, RP; Datko, LJ; Purvis, WF; Shaw, GW; Thompson, JL; Welch, TM, 1986) |
| " The effects of ibuprofen, methylprednisolone-sodium succinate, and gentamicin alone, or in combination on survival time and, TxA2 and PGI2 production in rats in a LD100 fecal peritonitis shock model were assessed." | 3.67 | Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock. ( Cook, JA; Halushka, PV; Knapp, RG; Wise, WC, 1985) |
| "The effects of prophylactic and delayed treatment with indomethacin were evaluated in a porcine model of early adult respiratory distress syndrome (ARDS) induced by endotoxaemia." | 3.67 | Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia. ( Borg, T; Gerdin, B; Modig, J, 1986) |
| " In series 1 during acute cardiac failure, indomethacin administration produced striking reductions in RHF but failed to alter the high level of plasma renin activity (PRA)." | 3.66 | Effects of indomethacin in conscious dogs with experimental high-output heart failure. ( Davis, JO; Dietz, JR; Echtenkamp, SF; Freeman, RH; Villarreal, D, 1983) |
| " 9 The results are also discussed in relation to the genesis of aspirin-induced asthma in man." | 3.66 | Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma. ( Ito, Y; Tajima, K, 1981) |
| "Following the induction of immunogenic uveitis betamethasone and dexamethasone reduced conjunctiva and iris hyperemia and aqueous flare." | 3.66 | Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin. ( Bhattacherjee, P; Eakins, KE; Kulkarni, PS; Srinivasan, BD, 1981) |
| "Topically applied indomethacin before and after pars plana lensectomy-vitrectomy in an experimental rabbit model reduces postoperative inflammation, as demonstrated by a statistically significant inhibition of protein elevation in the ocular fluid." | 3.66 | Anti-inflammatory action of topical indomethacin. ( Larson, B; Lavery, GW; Peyman, GA; Raichand, M, 1980) |
| "The effects of a number of steroids administered intra-articularly in a chronic model of fibrin-induced monoarticular arthritis in the rabbit have been investigated." | 3.66 | The local anti-inflammatory activity of rimexolone (Org 6216) in fibrin-induced monoarticular arthritis and adjuvant-induced arthritis. ( Lewis, AJ, 1980) |
| "The possibility that prostaglandin synthesis inhibition might favorably inhibit the development of animal adult respiratory distress syndrome models was investigated in two groups of dogs; one group was pretreated with indomethacin 3 mg/kg." | 3.66 | Failure of indomethacin to prevent or ameliorate oleic acid pulmonary edema in the dog. ( Blatnick, RA; Goitz, H; Johansen, RK; Pace, NL, 1980) |
| "In the present work it was determined the ability of non-steroidal anti-inflammatory drugs (Diflunisal and Indomethacin) to inhibit formation of "granuloma pouch" exudate induced in rats." | 3.66 | ["Granuloma pouch" reduction after treatment with indomethacin and diflunisal and collateral effects of these drugs on gastric mucosa]. ( Alesse, E; Bruno, G; Cifone, MG; Conti, P; Continenza, MA, 1980) |
| "Experimental models of chronic and acute peptic ulcerations were produced in the albino rats by means of prolonged starvation and indomethacin administration." | 3.66 | Comparative studies on starvation - and indomethacin - induced ulcerations in albino rats. ( Elegbe, RA, 1978) |
| "Acid phosphatase and beta-glucuronidase were used as marker enzymes of lysosome, and their role in adjuvant-induced uveitis was studied." | 3.66 | [The role of lysosomal enzymes in adjuvant-induced uveitis in rabbits (author's transl)]. ( Iso, T; Uda, K; Yamauchi, H, 1979) |
| "The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied." | 3.65 | Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977) |
| "A model is described of acute inflammation in the pleural cavity of rats using calcium pyrophosphate as the irritant." | 3.65 | Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation. ( Capasso, F; Deporter, DA; Dunn, CJ; Giroud, JP; Willoughby, DA; Yamamoto, S, 1975) |
| "The effects of single and multiple doses of indomethacin and multiple doses of nicotinic acid upon Escherichia coli endotoxin shock were studied in mongrel dogs anesthetized with sodium pentobarbital." | 3.65 | Effects of indomethacin and nicotinic acid on E. coli endotoxin shock in anesthetized dogs. ( Hilton, JG; Wells, CH, 1976) |
| "The healing of closed, non-immobilized femoral fractures in rats was seriously impaired by indomethacin given orally at a dose of 2 mg/kg daily." | 3.65 | Effect of indomethacin on fracture healing in rats. ( Bo, J; Marton, PF; Sudmann, E, 1976) |
| "Migraine is number seven in WHO's list of all diseases causing disability and the third most costly neurological disorder in Europe." | 2.49 | Animal migraine models for drug development: status and future perspectives. ( Jansen-Olesen, I; Olesen, J; Tfelt-Hansen, P, 2013) |
| " Epidemiological studies have shown that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing AD and delays its onset." | 2.43 | Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. ( Praticò, D; Townsend, KP, 2005) |
| "Gastric ulcer has been a major cause of morbidity and mortality worldwide, and it has been linked to factors such as nutritional deficiency, smoking, stress, and continuous intake of non-steroidal antiinflammatory drugs (NSAIDs)." | 1.72 | Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model. ( Carvalho, MF; Costa, EA; Fajemiroye, JO; Fava, SA; Ghedini, PC; Gil, ES; Gomes, EH; Macedo, IYL; Martins, JLR; Pinto, EMH; Rocha, FF; Silva, DM; Silva, ON, 2022) |
| "Uric acid (UA) has anti- and pro-inflammatory properties." | 1.72 | Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota. ( Akiyama, M; Hanawa, Y; Higashiyama, M; Hokari, R; Horiuchi, K; Inaba, K; Ito, S; Komoto, S; Kurihara, C; Mizoguchi, A; Nishii, S; Okada, Y; Shibuya, N; Sugihara, N; Takei, F; Tanemoto, R; Tomita, K; Wada, A; Watanabe, C, 2022) |
| "Olmesartan (OLM) has potent anti-oxidant and anti-inflammatory characters, yet having limited bioavailability." | 1.62 | Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway. ( Darwish, SF; El-Dakroury, WA; Radwan, E; Sallam, AM, 2021) |
| "Rebamipide (REB) a potent anti-ulcer agent, has not been exploited to its full potential, owing to it extremely poor solubility, leading to highly diminutive bioavailability (<10%)." | 1.62 | Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies. ( Chadha, R; Dureja, J; Jindal, A; Karan, M; Singh, R; Tomar, S, 2021) |
| "Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels." | 1.62 | The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021) |
| " The mechanism underpinning pain relief induced by the GlyT2 inhibitor at 10 mg/kg is likely due to increased glycinergic inhibition in the lumbar spinal cord, although the bell-shaped dose-response curve warrants further translational considerations." | 1.62 | Assessment of the Anti-Allodynic and Anti-Hyperalgesic Efficacy of a Glycine Transporter 2 Inhibitor Relative to Pregabalin, Duloxetine and Indomethacin in a Rat Model of Cisplatin-Induced Peripheral Neuropathy. ( Corradini, L; Kuo, A; Nicholson, JR; Smith, MT, 2021) |
| "Acute kidney injury affects nearly 30% of preterm neonates in the intensive care unit." | 1.56 | Nephron loss detected by MRI following neonatal acute kidney injury in rabbits. ( Baldelomar, EJ; Bennett, KM; Cathro, HP; Charlton, JR; Charlton, NP; Criswell, SJ; deRonde, KA; Hyatt, DM; Nam, S; Pearl, V, 2020) |
| "2 ml 35 µM indomethacin solution (resulting in a final concentration of 8 µg/ml in the follicular fluid) was the minimal dosage leading to COF formation." | 1.56 | Induction of cystic ovarian follicles (COFs) in cattle by using an intrafollicular injection of indomethacin. ( Lapp, R; Röttgen, V; Vernunft, A; Viergutz, T; Weitzel, JM, 2020) |
| "Naringin is a promising anti-inflammatory drug against various disorders including ulcerative colitis." | 1.56 | Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits. ( Borg, TM; El Naggar, EE; El-Sheakh, AR; Hamed, MF; Mohamed, EA, 2020) |
| "The neurochemical mechanisms underlying neuropathic pain (NP) are related to peripheral and central sensitization caused by the release of inflammatory mediators in the peripheral damaged tissue and ectopic discharges from the injured nerve, leading to a hyperexcitable state of spinal dorsal horn neurons." | 1.56 | Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury. ( Coimbra, NC; da Silva, JA; de Freitas, RL; Dos Santos, IR; Ferreira, SH; Medeiros, AC; Medeiros, P, 2020) |
| "Gastric ulcers were induced in male Sprague-Dawley (SD) rats with a single oral dose of 150 mg/kg IND." | 1.56 | Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway. ( Cai, X; Chen, X; Hou, X; Peng, J; Peng, Q; Song, H; Xu, F; Yang, T; Yu, R; Zeng, M, 2020) |
| "Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days." | 1.51 | Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice. ( Hajhashemi, V; Mesripour, A; Shahnooshi, S, 2019) |
| "The indomethacin treatment increased the level of p53 in the leukemic cells, implying that COX inhibition might reduce progression of ALL by attenuating protective paracrine PGE2 signaling from bone marrow stroma to leukemic cells." | 1.51 | Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model. ( Bhagwat, S; Blomhoff, HK; Burman, MM; Duthil, E; Ford, A; Gilljam, KM; Naderi, EH; Richartz, N; Ruud, E; Skah, S, 2019) |
| "Crohn's disease is a type of inflammatory bowel disease of unknown etiology." | 1.51 | Elemental Diet Regulates Intestinal Permeability and Antibody Production in Indomethacin-Induced Intestinal Injury Rats. ( Akahoshi, A; Kikuchi, Y; Matsuo, M; Minami, H; Nabeta, C, 2019) |
| "The long-term use of anti-inflammatory drugs is the most common cause of gastric ulcer disease, one of the major gastrointestinal disorders affecting people worldwide." | 1.51 | Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice. ( Alves, GM; Assis, ALEM; Athaydes, BR; Campagnaro, BP; Gomes, JVD; Gonçalves, RCR; Kitagawa, RR; Kuster, RM; Nogueira, BV; Pereira, TMC; Rodrigues, RP; Silveira, D, 2019) |
| "Gastric ulcer is a common problem affecting the gastrointestinal tract." | 1.51 | A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats. ( Abdelwahed, MK; Ahmed, EI; Boushra, AF; Elsayed, AM; Ibrahim, NA, 2019) |
| "Indomethacin was administered (from 3 days prior with daily oral administration) to mice in which aortic dissection was induced using beta-aminopropionitrile (BAPN) and angiotensin II (Ang II) infusion (2 weeks)." | 1.51 | Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model. ( Aizawa, K; Aoki, H; Imai, Y; Nagai, R; Nishida, N; Suzuki, T; Tomida, S, 2019) |
| "Treatment with Indomethacin had no pronounced effect on the immune system or bacterial burden." | 1.48 | A novel model to study neonatal Escherichia coli sepsis and the effect of treatment on the human immune system using humanized mice. ( Entleutner, K; Ernst, W; Fill Malfertheiner, S; Schlieckau, F; Schulz, D; Seelbach-Goebel, B, 2018) |
| "Indomethacin has a pro-neurogenic and thereby restorative effect and an anti-inflammatory effect on the cellular level in the DG following MPTP treatment." | 1.48 | Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion. ( Akyüz, L; Hain, EG; Klein, C; Rasińska, J; Sparenberg, M; Steiner, B, 2018) |
| "Most drugs used to treat pain and inflammation have potential side effects, which makes it necessary to search for new sources of bioactive molecules." | 1.48 | LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice. ( Alencar Filho, EB; Almeida, JRGDS; Barreiro, EJL; Diniz, TC; Lavor, ÉM; Lima, LM; Lima-Saraiva, SRG; Mendes, RL; Oliveira Júnior, RG; Silva, JC; Silva, MGE; Soares, JMD, 2018) |
| "Baicalin was 72% effective versus the reference drug and 80% effective against ethanol-induced ulcers." | 1.46 | Baicalin protects against gastroduodenal ulcers via the modulation of Nrf2 expression: Experimental, biochemical, and histological analyses. ( Meng, X; Yang, D; Zhang, T, 2017) |
| "Treatment with uric acid protected Caco-2 cells from indomethacin-induced oxidative stress, lipid peroxidation, and cytotoxicity." | 1.46 | Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity. ( Furuhashi, H; Higashiyama, M; Hokari, R; Komoto, S; Kurihara, C; Maruta, K; Matsuo, H; Miura, S; Nagao, S; Narimatsu, K; Okada, Y; Sato, H; Shirakabe, K; Takajo, T; Tomita, K; Watanabe, C; Yasutake, Y; Yoshikawa, K, 2017) |
| "Crohn's disease is a common inflammatory manifestation in humans and other animal species relating to the ulceration and digestive disturbances in upper gastro-intestinal tract." | 1.43 | Emu oil offers protection in Crohn's disease model in rats. ( Pandiyan, V; Selvasubramanian, S; Vemu, B, 2016) |
| " faecalisovergrowth was independent of the route of administration of the drug, as similar findings were observed in rats orally dosed with theNSAID Bile secretion plays an important role inINDO-induced gut injury and appears to support enterococcal overgrowth of the intestine." | 1.43 | Indomethacin injury to the rat small intestine is dependent upon biliary secretion and is associated with overgrowth of enterococci. ( Cruz, MR; Dial, EJ; Garsin, DA; Lichtenberger, LM; Mayo, SA; Murray, BE; Phan, TM; Singh, KV; Song, YK, 2016) |
| "Treatment with sulfasalazine, low dose of natrexone or their combination resulted in significant improvement of all measured parameters compared with enteritis group." | 1.43 | Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats. ( Abdel-Salam, LO; Kamel, MM; Khattab, A; Osman, AS; Tawfik, DI; Tolba, HM, 2016) |
| "Small intestinal ulcers are a serious adverse effect commonly occurring in patients taking nonsteroidal anti-inflammatory drugs." | 1.43 | Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Kawauchi, S; Mizuno, S; Nakamura, T; Rikitake, Y; Tanahashi, T, 2016) |
| " Hence, inflammatory diseases may impose variability in drug bioavailability through alterations in the intestinal expression and activity of drug transporters." | 1.42 | Changes of Absorptive and Secretory Transporting System of (1 → 3) β-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat. ( Aketagawa, J; Hayashi, M; Iida, A; Ito, Y; Oda, T; Ouchi, S; Takizawa, Y; Tomita, M, 2015) |
| " The mechanisms for impaired cerebral artery endothelial function are reduced nitric oxide bioavailability and increased oxidative stress." | 1.42 | Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness. ( Dobson, PS; Donato, AJ; Henson, GD; Lesniewski, LA; Li, DY; Ling, J; Mecham, RP; Morgan, RG; Nielson, EI; Reihl, KD; Walker, AE, 2015) |
| "CSA hypertension was associated with renal perivascular fibrosis and divergent changes in immunohistochemical signals of renal arteriolar ETA (increases) and ETB (decreases) receptors." | 1.42 | Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling. ( Ali, RM; El-Gowelli, HM; El-Mas, MM; Helmy, MW, 2015) |
| "Eighteen (90%) wounds in the saline-chitosan group and 11 (55%) wounds in the saline-gauze group were healed." | 1.42 | Locally Delivered Nonsteroidal Antiinflammatory Drug: A Potential Option for Heterotopic Ossification Prevention. ( Hsu, JR; Noel, SP; Rathbone, CR; Rivera, JC; Wenke, JC, 2015) |
| " The lead compound demonstrated very good oral bioavailability in mice, slow metabolic degradation, modest distribution into the brain and a remarkable anti-inflammatory efficacy in carrageenan-induced mouse paw edema model." | 1.40 | Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core. ( Gavalas, A; Geronikaki, A; Hammock, B; Hwang, SH; Iurchenko, V; Ivanenkov, Y; Krasavin, M; Morisseau, C; Mujumdar, P; Sarnpitak, P; Zozulya, S, 2014) |
| "Pain is the most common reason a patient sees a physician." | 1.40 | Antinociceptive properties of physalins from Physalis angulata. ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014) |
| " Dose-response curves were obtained with phenylephrine, acetylcholine and sodium nitroprusside." | 1.40 | Influence of decompression sickness on vasomotion of isolated rat vessels. ( Belhomme, M; Buzzacott, P; Guerrero, F; Lambrechts, K; Mansourati, J; Mazur, A; Theron, M; Wang, Q, 2014) |
| "Based on X-ray and histological results, heterotopic ossification was assessed." | 1.40 | [Effects of selective and non-selective cyclooxygenase 2 inhibitors on heterotopic ossification in rat model with Achilles tenotomy]. ( Shi, W; Wu, J; Xiao, H; Xue, F; Zhao, H, 2014) |
| "Indomethacin (10 mg/kg) was administered once per week for six weeks in 8- and 26-week rats and animals were sacrificed every week after administration." | 1.40 | Difficult establishment of a chronic nonsteroidal anti-inflammatory drugs induced gastric inflammation rat model due to gastric adaptation and small bowel damage. ( Kim, N; Lee, BH; Lee, CH; Lee, DH; Lee, HS; Lee, JY; Nam, RH; Park, JH, 2014) |
| "Indomethacin treatment and castration weaken immune responses and clinical state of infected rats, while testosterone and estradiol have a beneficial effect." | 1.40 | The effect of indomethacin, myeloperoxidase, and certain steroid hormones on bactericidal activity: an ex vivo and in vivo experimental study. ( Békési, G; Dinya, E; Ghidán, Á; Magyar, T; Marczell, I; Nagy, K; Rácz, K; Stark, J; Székács, B; Szombath, D; Tulassay, Z; Vajdovich, P; Várbíró, S; Varga, Z, 2014) |
| " Vancomycin (VCM), a poorly absorbed drug, was administered intraduodenally to rats with SIUs." | 1.40 | Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Inoue, J; Kawauchi, S; Miki, I; Mizuno, S; Nakamura, T; Nishikawa, C; Tanahashi, T; Yasui, H, 2014) |
| "Indomethacin ulcers were produced by oral administration of 30 mg/kg bw in the rats pretreated with B-Hb one hour before indomethacin." | 1.39 | Gastric antisecretory and antiulcer activity of bovine hemoglobin. ( Al Asmari, AK; Al Asmary, S; Al Malki, A; Al Omani, S; Elfaki, I; Tariq, M, 2013) |
| "Montelukast is an anti-asthmatic drug, a selective reversible cysteinyl leukotriene D4 receptor antagonist." | 1.39 | Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model. ( Cadırcı, E; Ozbakış-Dengiz, G; Yurdakan, G, 2013) |
| "Lung cancer is frequently complicated by pulmonary infections which may impair prognosis of this disease." | 1.39 | Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation. ( Banat, GA; Dahlem, G; Eul, B; Fink, L; Goldmann, T; Grandel, U; Grimminger, F; Hattar, K; Lang, DS; Savai, R; Schermuly, RT; Schmall, A; Seeger, W; Sibelius, U; Subtil, FS; Vollmer, E; Wilhelm, J, 2013) |
| "Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use, such as etoposide, teniposide and etopophos." | 1.39 | Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. ( Abad, A; Del Olmo, E; Guerrero, E; López-Pérez, JL; Montenegro, G; San Feliciano, A, 2013) |
| "Metformin treatment improved these alterations." | 1.38 | Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. ( Akamine, EH; Carvalho, MH; Filgueira, FP; Fortes, ZB; Hagihara, GN; Lobato, NS; Pariz, JR; Tostes, RC, 2012) |
| "Ischemia/reperfusion injury was induced by clamping left renal pedicle for 60 min, two weeks after right nephrectomy." | 1.38 | Protective effects of acute lithium preconditioning against renal ischemia/reperfusion injury in rat: role of nitric oxide and cyclooxygenase systems. ( Assa, S; Dehpour, AR; Elmi, A; Emami, H; Ghasemi, M; Nezami, BG; Talab, SS; Tavangar, SM, 2012) |
| "Indomethacin cytotoxicity was determined by lactate dehydrogenase release from murine gastric epithelial GSM06 cells induced by 24-h treatment with 200 and 400 μM indomethacin after 1-h preincubation with 100 μg/ml sake yeast-derived thioredoxin." | 1.38 | Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin. ( Fukui, T; Kishimoto, M; Nakajima, A; Nakayama, S; Nishio, A; Okazaki, K; Sakaguchi, Y; Takahashi, Y; Uchida, K; Yamashina, M; Yodoi, J; Yoshida, K, 2012) |
| "Indomethacin (10 mg/kg) was administered subcutaneously to male Wistar rats to induce small intestinal damage and the severity of the intestinal injury was evaluated by measuring the area of visible ulcerative lesions." | 1.38 | Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin. ( Handa, O; Hirai, Y; Ichikawa, H; Ishikawa, T; Kamada, K; Katada, K; Kokura, S; Konishi, H; Mizushima, K; Naito, Y; Okada, H; Oya-Ito, T; Takagi, T; Takaoka, M; Uchiyama, K; Yagi, N; Yamada, S; Yoshida, N; Yoshikawa, T, 2012) |
| "Celecoxib has a positive effect on human osteoarthritic cartilage, but the mechanisms remain unclear." | 1.38 | Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte. ( An, H; Jiang, D; Luo, X; Ou, Y; Quan, Z; Tan, C; Tang, K, 2012) |
| "Indomethacin was orally administered to induce an acute gastric injury (3, 10 and 30mg/kg)." | 1.38 | Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. ( Castañeda-Hernández, G; Chávez-Piña, AE; Jiménez-Andrade, JM; Pineda-Peña, EA, 2012) |
| "Acetaminophen is a safe antipyretic and analgesic drug within the clinically recommended dosage range, but overdose can cause fatal liver and or kidney damage." | 1.38 | Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats. ( Arimizu, K; Chuang, VT; Hirata, S; Irie, T; Ishitsuka, Y; Kadowaki, D; Kitamura, K; Maruyama, T; Narita, Y; Otagiri, M; Sumikawa, S; Taguchi, K, 2012) |
| " Teduglutide, a recombinant human GLP2 variant (GLP2-2G), has increased half-life and stability as compared to the native GLP2 peptide, but still requires twice daily dosing in preclinical models and daily dosing in the clinic." | 1.38 | GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model. ( Alters, SE; Lachinyan, T; McLaughlin, B; Podust, V; Schellenberger, V; Spink, B; Stemmer, WP; Wang, CW, 2012) |
| "Indomethacin was used as standard reference drug." | 1.37 | Lactobacillus casei reduces the inflammatory joint damage associated with collagen-induced arthritis (CIA) by reducing the pro-inflammatory cytokines: Lactobacillus casei: COX-2 inhibitor. ( Amdekar, S; Keshav, P; Kumar, A; Sharma, P; Singh, R; Singh, V, 2011) |
| "Indomethacin (10 mg/kg) was subcutaneously administered to induce small-intestinal damage." | 1.37 | Reduced small-intestinal injury induced by indomethacin in interleukin-17A-deficient mice. ( Fukumoto, K; Handa, O; Harusato, A; Hirai, Y; Horie, R; Inoue, K; Ishikawa, T; Kita, M; Kokura, S; Konishi, H; Mizushima, K; Naito, Y; Takagi, T; Uchiyama, K; Wakabayashi, N; Yagi, N; Yamada, S; Yoshida, N; Yoshikawa, T, 2011) |
| "05), in a dosage range from 4." | 1.37 | Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models. ( Badilla, B; García-Barrantes, PM, 2011) |
| "Risperidone pretreatment reverses the stress induced alteration in hexosamine, PGE(2) and microvascular permeability." | 1.37 | Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions. ( Krishnamurthy, S; Saxena, B; Singh, S, 2011) |
| "Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions." | 1.37 | Curative effect of selenium against indomethacin-induced gastric ulcers in rats. ( Kim, BW; Kim, JH; Kwon, HJ; Nam, SW, 2011) |
| "Milnacipran was significantly and dose dependently active against the decrease of paw withdrawal threshold produced by complete Freund's adjuvant for low (minimum effective dose=5 mg/kg, range tested: 2." | 1.37 | Effects of milnacipran, duloxetine and indomethacin, in polyarthritic rats using the Randall-Selitto model. ( Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O, 2011) |
| " Oral administration of IAC dosed at 50 and 100 mg/kg was able to significantly prevent gastric ulceration induced by indomethacin and by stress." | 1.37 | Further evidence of the antiulcer activity of IAC, a novel free radical scavenger. ( Baraldi, M; Carnevale, G; Zanoli, P; Zavatti, M, 2011) |
| "Dillapiole and safrole were isolated and purified using column chromatography." | 1.37 | The anti-inflammatory activity of dillapiole and some semisynthetic analogues. ( Agostinho, LA; Brandt, CA; de Souza, T; Motter Magri, FM; Parise-Filho, R; Pastrello, M; Pereira Camerlingo, CE; Polli, MC; Ribeiro, RR; Silva, GJ, 2011) |
| " In conclusion, gastroprotective effect on ethanol and indomethacin-induced ulcer promoted by (-)-alpha-bisabolol may be associated with an increase of gastric sulfydryl groups bioavailability leading to a reduction of gastric oxidative injury induced by ethanol and indomethacin." | 1.36 | Gastroprotection of (-)-alpha-bisabolol on acute gastric mucosal lesions in mice: the possible involved pharmacological mechanisms. ( Aquino Neto, MR; de França Fonteles, MM; de Sousa, DP; de Sousa, FC; Gomes Silva, MI; Mendes Vasconcelos, SM; Moura Rocha, NF; Moura, BA; Vasconcelos Rios, ER; Venâncio, ET, 2010) |
| "Inflammation was induced by injection of 0." | 1.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| "Furosemide was also s." | 1.36 | In vivo dilatation of the ductus arteriosus induced by furosemide in the rat. ( Momma, K; Nakanishi, T; Toyoshima, K, 2010) |
| "Inflammation is related to neutrophil infiltration and the production of neutrophil-derived mediators and free radicals." | 1.36 | Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models. ( Aslan, A; Aygun, H; Cakir, A; Halici, Z; Odabasoglu, F; Suleyman, H; Tanas, S, 2010) |
| "Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36." | 1.36 | Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs. ( Bures, J; Kopácová, M; Kunes, M; Kvetina, J; Osterreicher, J; Pejchal, J; Rejchrt, S; Spelda, S; Tachecí, I, 2010) |
| "Necropsy revealed patent ductus arteriosus with normal intimal thickening but dilated cardiac chambers." | 1.36 | Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice. ( Chang, HY; Locker, J; Lu, R; Schuster, VL, 2010) |
| "The same procedure suppressed allodynia and hyperalgesia in the cancer model, but the suppression was weak when compared with that in the inflammation model." | 1.36 | Differences between orofacial inflammation and cancer pain. ( Harano, N; Hidaka, K; Inenaga, K; Kai, A; Nakanishi, O; Ono, K, 2010) |
| " For these studies, animals were dosed with CP-154,526 (3, 10, 30 mg/kg) and NBI 27914 (1-30 mg/kg) 1 h prior to the assessment of tactile, thermal or mechanical hypersensitivity, respectively." | 1.36 | Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. ( Cummons, T; Harrison, JE; Hummel, M; Kennedy, JD; Lu, P; Mark, L; Whiteside, GT, 2010) |
| "Periodontitis was produced by a ligature placed around the cervix of the two lower first molar." | 1.36 | Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis. ( Borda, E; Busch, L; Miozza, V; S-Borda, L, 2010) |
| "Indomethacin treatment significantly decreased cotton pellet implantation induced white blood cell count elevation and immune cells infiltration in epididymal white adipose tissue." | 1.36 | Indomethacin activates peroxisome proliferator-activated receptor γ to improve insulin resistance in cotton pellet granuloma model. ( Chen, W; Cheng, JT; Cheng, KC; Shen, KH; Wu, HT; Yeh, CH, 2010) |
| "Duplicated COPD model rats were divided into two groups: the malnutrition group and the normal nutrition group." | 1.36 | [The influence of indomethacin on TNFα and skeletal muscle protein catabolism in chronic obstructive pulmonary disease rat model]. ( Gao, J; Lin, H; Liu, C; Sun, SH; Zhan, J, 2010) |
| "Pretreatment with irsogladine maleate markedly reduced the number and severity of these lesions in a dose-dependent manner." | 1.35 | Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats. ( Kageyama, K; Kyoi, T; Tajima, K; Zhang, X, 2008) |
| " In our experiment acute and/or chronic administration of lithium before prolonged ischemia offered significant myoprotective effects in terms of infarct size reduction and improved cardiac function against ischemia/reperfusion injury." | 1.35 | Preconditioning with acute and chronic lithium administration reduces ischemia/reperfusion injury mediated by cyclooxygenase not nitric oxide synthase pathway in isolated rat heart. ( Bazargan, M; Dehpour, AR; Faghihi, M; Mirershadi, F, 2008) |
| "Since type 2 diabetes impairs endothelial sensitivity to flow and increases oxidative stress, we hypothesized that flow-induced remodelling in RAs would be impaired in diabetes." | 1.35 | Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow. ( Belin de Chantemèle, EJ; Guihot, AL; Henrion, D; Loufrani, L; Maquignau, M; Toutain, B; Vessières, E, 2009) |
| "Arachidonic acid metabolites have been implicated in development of periodontal disease, especially those derived from the cyclo-oxygenase (COX) pathway." | 1.35 | Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats. ( Caliari, MV; Duarte, ID; Francischi, JN; Maltos, KL; Pacheco, CM; Queiroz-Junior, CM, 2009) |
| "Methods used included the in-vitro inhibition of cyclooxygenase-1 and -2, in-vivo evaluation of anti-inflammatory activity by air pouch and peritonitis models and the pharmacokinetic profile after intravenous (3 mg/kg) and oral (3 and 6 mg/kg) dosing to rats." | 1.35 | Preclinical pharmacokinetic and pharmacodynamic evaluation of thiazolidinone PG15: an anti-inflammatory candidate. ( da Silva, TG; Dalla Costa, T; de Lima, Mdo C; Galdino, SL; Pitta, Ida R; Uchôa, Fde T, 2009) |
| "Indomethacin is used to close the patent ductus arteriosus in premature infants and for tocolysis of preterm labor." | 1.35 | Delayed neonatal closure of the ductus arteriosus following early in utero exposure to indomethacin in the rat. ( Imamura, S; Ito, K; Momma, K; Nakanishi, T; Sugiyama, K; Sun, F; Toyoshima, K, 2009) |
| "In indomethacin-treated animals, esomeprazole was more effective than famotidine or the antioxidant melatonin in promoting ulcer healing." | 1.35 | Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. ( Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M, 2009) |
| "During the first stage of human African trypanosomiasis (HAT), Trypanosoma brucei gambiense is found mainly in the blood, and pentamidine treatment is used." | 1.35 | Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. ( De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA, 2009) |
| "Cryptolepine has been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor-kappa B following inflammatory stimuli in vitro." | 1.35 | Anti-inflammatory properties of cryptolepine. ( Ajayi, AM; Olajide, OA; Wright, CW, 2009) |
| "Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent." | 1.35 | Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. ( Albayrak, F; Alp, HH; Bilici, M; Dursun, H; Ozturk, C; Saglam, MB; Suleyman, H, 2009) |
| "Although long-term use of cyclooxygenase (COX)-2 inhibitors may be associated with increased cardiovascular risk, their effects on vascular reactivity in atherosclerosis has remained largely unexplored." | 1.35 | Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. ( Bäck, M; Brink, C; Foudi, N; Louedec, L; Michel, JB; Norel, X; Rienzo, M, 2009) |
| "Cutaneous leishmaniasis is still one of the health problems in Iran and in the region." | 1.35 | Evaluation of anti-leishmanial activity by induction of nitric oxide and inhibition of prostaglandin in Balb/c mice infected with Leishmania major. ( Arjmand, M; Farahmand, M; Ghasemi, F; Hajihosseini, R; Nahrevanian, H, 2009) |
| "Colitis was induced by the intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid in rats, reactivated 6 weeks later." | 1.35 | Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon. ( Appleyard, CB; Morales, M; Santiago, C, 2008) |
| " The BK dose-response curve was shifted to the right by topical indomethacin." | 1.35 | A novel model of pain sensation using superfused gastrosplenic omentum preparation of anesthetized rats. ( Katori, M; Majima, M; Yang, SJ, 2008) |
| "Pretreatment with wortmannin, capsazepine, DNK333 (a dual neurokinin (NK) 1 and NK2 antagonist) or the anti-allergy drug CGS8515, but not indomethacin, resulted in partial inhibition." | 1.35 | In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI. ( Beckmann, N; Blé, FX; Cannet, C; Fozard, JR; Karmouty-Quintana, H; Page, CP; Zurbruegg, S, 2008) |
| "The pathogenesis of heterotopic ossification is still unclear and the preventive therapies are usually insufficient." | 1.34 | Free radical scavengers are more effective than indomethacin in the prevention of experimentally induced heterotopic ossification. ( De Cock, K; De Muynck, M; Rimbaut, S; Van Maele, G; Vanden Bossche, LC; Vanderstraeten, GG; Vertriest, S; Wojtowicz, I, 2007) |
| "An animal model of cancer pain induced by injection of Walker 256 carcinoma cells into the plantar surface of rat hind paw is described." | 1.34 | Walker 256 tumor-bearing rats as a model to study cancer pain. ( Brigatte, P; Curi, R; Cury, Y; Guerra, JL; Gutierrez, VP; Sampaio, SC; Sinhorini, IL, 2007) |
| "When ticlopidine was administered 1h after EtOH, it significantly (p<0." | 1.34 | Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. ( De Luca, V; Guidobono, F; Lattuada, N; Netti, C; Pagani, F; Sibilia, V; Soglian, A, 2007) |
| "However, indomethacin-induced nasal blockage was not provoked in non-sensitized animals." | 1.34 | Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis. ( Fujii, M; Han, HY; Kohno, S; Mizutani, N; Nabe, T; Takenaka, H; Terada, T, 2007) |
| "Esophageal and tongue cancers have both been associated with dietary zinc deficiency (ZD), and cyclooxygenase (COX-2) is often overexpressed in these cancers." | 1.33 | Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. ( Farber, JL; Fong, LY; Jiang, Y; Zhang, L, 2005) |
| "Rats treated with indomethacin had significant higher plasma levels of TNF-alpha (indomethacin vs N/S: 22+/-5 vs 10+/-1 pg/mL, P<0." | 1.33 | Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure. ( Chan, CY; Chang, FY; Chen, YC; Chu, CJ; Hsiao, CC; Huang, HC; Lee, FY; Lee, SD; Wang, SS; Wang, TF, 2005) |
| "In contrast, analgesia, sedation and catalepsy were not observed in this dose range, but were apparent at 100 mg/kg." | 1.33 | Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. ( Boulet, JM; Chaffer, SM; Elsemore, DA; Gottshall, SL; Harrison, JE; Koetzner, L; Lee, G; Mark, L; Miller, W; Pearson, MS; Rabadi, L; Rotshteyn, Y; Shan, S; Tafesse, L; Toth, M; Turchin, PI; Valenzano, KJ; Whiteside, GT, 2005) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 1.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "Indomethacin was less effective, though tissue prostaglandin E2 but not leukotriene B4 levels were reduced." | 1.33 | The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo. ( Andrews, G; Colville-Nash, P; Freemantle, C; Lam, C; Papworth, J; Willis, D; Willoughby, D, 2005) |
| "CION caused ipsilateral cold hyperalgesia between Days 2 and 12, which peaked on Days 4 (sham 15." | 1.33 | Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs. ( Chichorro, JG; Rae, GA; Souza, GE; Zampronio, AR, 2006) |
| "Gastric ulcer is a source of visceral pain." | 1.33 | Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats. ( Bogdanov, A; Filaretova, L; Yarushkina, N, 2006) |
| "As parameters of epileptic seizure, seizure threshold (number of toss-ups to induce convulsion), duration of actual convulsion and duration of post actual convulsive period (period from the offset of convulsion to full recovery) were evaluated." | 1.33 | Cyclooxygenase system contributes to the maintenance of post convulsive period of epileptic phenomena in the genetically epileptic El mice. ( Okada, K; Tsuji, S; Yamashita, U, 2006) |
| " In this study, NS-398, a specific COX-2 inhibitor, and indomethacin, a COX-1 and COX-2 inhibitor, were administered 24 h after chloroform dosing to determine their effect on liver injury in Sprague-Dawley rats." | 1.32 | Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. ( Begay, CK; Gandolfi, AJ, 2003) |
| "Indomethacin is a clinically applied nonsteroidal antiphlogistic, and in previous studies in the rat, it has been found to induce an inflammatory reaction in the small intestine characterized by edema and reddening of the intestinal epithelium, ulceration, and dysregulation in the intestinal-epithelial barrier function." | 1.32 | Effect of N-acetylcysteine on microcirculation of mucosa in rat ileum in a model of intestinal inflammation. ( Ruh, J; Schmidt, E; Vogel, F, 2003) |
| "Indomethacin (3 mg/kg) was then compared to celecoxib (4." | 1.32 | Indomethacin and celecoxib improve tendon healing in rats. ( Aspenberg, P; Bylander, B; Forslund, C, 2003) |
| "3." | 1.32 | Pharmacological characterisation of a rat model of incisional pain. ( Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT, 2004) |
| "Treatment with indomethacin increased sleep efficiency (p<0." | 1.32 | Sleep alterations in an experimental orofacial pain model in rats. ( Andersen, ML; Schütz, TC; Tufik, S, 2003) |
| "The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems, which upon instillation as drops into the eye undergo a sol-gel transition in the cul-de-sac." | 1.32 | In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin. ( Balasubramaniam, J; Kant, S; Pandit, JK, 2003) |
| "The effect of hyperlipemia associated with diabetes on the contractility of resistance arteries to prostaglandin F2alpha (PGF2alpha) was investigated employing 4 weeks simultaneously hyperlipemic-diabetic (HD), hyperlipemic (H), diabetic (D) and normal hamsters (controls, C)." | 1.32 | The contractile response of the mesenteric resistance arteries to prostaglandin F2alpha; effects of simultaneous hyperlipemia-diabetes. ( Georgescu, A; Popov, D, 2003) |
| " The dosage of 230 mg/kg of nicotinamide given intraperitoneally 15 min before STZ administration (65 mg/kg i." | 1.32 | Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats. ( Kamata, K; Kobayashi, T; Matsumoto, T; Wakabayashi, K, 2004) |
| "Indomethacin was administered subcutaneously in the daily dose of 5, 7, 10, 20 and 30 mg/kg b." | 1.32 | Contribution to safe anti-inflammatory therapy with indomethacin. ( Bauerová, K; Mihalová, D; Navarová, J; Nosál'ová, V, 2004) |
| "pretreatment with indomethacin." | 1.32 | Ghrelin-a new gastroprotective factor in gastric mucosa. ( Brzozowski, T; Drozdowicz, D; Hahn, EG; Harsch, I; Konturek, PC; Konturek, SJ; Kwiecien, S; Nikiforuk, A; Pajdo, R, 2004) |
| "The influence of left ventricular hypertrophy (LVH) on the endothelial function of resistance endocardial arteries is not well established." | 1.32 | Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy. ( Gendron, ME; Perrault, LP; Thorin, E, 2004) |
| " There was a reduction in PGE2 levels on chronic administration of celecoxib in DSS-treated animals." | 1.32 | Aggravation of inflammatory bowel disease by cyclooxygenase-2 inhibitors in rats. ( Jain, NK; Kulkarni, SK; Patil, CS; Singh, VP, 2004) |
| "Sumatriptan was not able to reverse either the kainic acid-induced or the NMDA-induced hyperalgesia." | 1.32 | Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine. ( Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C, 2004) |
| "Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited UV-induced ear swelling, abrogated local immunosuppression, and decreased the amount of PGE2 in the ear skin of XPA-deficient mice." | 1.31 | Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice. ( Eguchi, N; Horio, T; Inui, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Tanaka, K; Urade, Y, 2000) |
| "Indomethacin co-treatment partially prevented blood pressure elevation, restored responsiveness to phenylephrine and improved sensitivity to acetylcholine." | 1.31 | Cyclooxygenase inhibition reduces blood pressure elevation and vascular reactivity dysfunction caused by inhibition of nitric oxide synthase in rats. ( da Cunha, V; Oliveira, PA; Poton, S; Pretti, SC; Rossoni, LV; Stefanon, I; Vassallo, DV, 2000) |
| "Ebrotidine is a new H2 receptor antagonist that potentiates the gastric mucosal barrier." | 1.31 | Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine. ( Arroyo, MT; Lanas, A; Sáinz, R, 2000) |
| "Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid." | 1.31 | Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. ( Ajuebor, MN; Singh, A; Wallace, JL, 2000) |
| "Pre-treatment with indomethacin significantly reduced the protective effect of the extract against HCl/ethanol solution to 31%." | 1.31 | Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats. ( Dimo, T; Dongo, E; Tan, PV, 2000) |
| "The oedema has distinct borders to the surrounding connective tissue and is separated and removed easily for further analysis." | 1.31 | A new technique for the analysis of endogenous mediators released following thermal injury. ( Cassuto, J; Lindblom, L; Löwhagen, PH; Nilsson, U; Räntfors, J; Tarnow, P; Yregård, L, 2001) |
| "Pretreatment with indomethacin, a cyclooxygenase inhibitor, also inhibited the carrageenin-induced responses significantly in normal rats." | 1.31 | Evidence for bradykinin mediation of carrageenin-induced inflammatory pain: a study using kininogen-deficient Brown Norway Katholiek rats. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "Using a murine model of metastatic breast cancer, we show that PGE(2) levels are positively correlated with increased tumorigenic and metastatic potential." | 1.31 | Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. ( Dorsey, R; Fulton, AM; Kundu, N; Yang, Q, 2001) |
| "Metronidazole was more potent than amoxicillin/clavulanic acid and anti-tumour necrosis factor in improving the indometacin-induced small bowel inflammation." | 1.31 | Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model. ( Ceuppens, JL; Colpaert, S; De Greef, B; Geboes, K; Liu, Z; Rutgeerts, P, 2001) |
| "Indomethacin treatment reversed all the measured parameters, although the reversal of mechanical allodynia was only partial." | 1.31 | Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis. ( Fuseler, J; Grisham, M; Roerig, SC; Tedesco, LS; Wolf, R, 2002) |
| "are used for the treatment of peptic ulcers." | 1.30 | Effects of Cistus laurifolius L. flowers on gastric and duodenal lesions. ( Ergun, E; Gürbüz, I; Yeşilada, E, 1997) |
| "We tried to produce a new ulcerative colitis model in rats by topical administration of sulfhydryl blockers." | 1.30 | New ulcerative colitis model induced by sulfhydryl blockers in rats and the effects of antiinflammatory drugs on the colitis. ( Sato, F; Satoh, H; Szabo, S; Takami, K, 1997) |
| "Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20 microliters of 20% acetic acid." | 1.30 | [A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump]. ( Katoh, Y; Kawashima, H; Tanaka, M, 1997) |
| " The decrease in edema in the footpads of EFAD rats was nearly identical to the decrease in edema in the footpads of Control rats dosed with indomethacin." | 1.30 | Modulation of adjuvant-induced arthritis by dietary arachidonic acid in essential fatty acid-deficient rats. ( Chinn, KS; Mehta, A; Obukowicz, MG; Raz, A; Salsgiver, WJ; Welsch, DJ, 1997) |
| "Pretreatment with glycine significantly protected animals against stress-, indomethacin- and necrotizing agents induced gastric lesions." | 1.30 | Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine. ( Al Moutaery, AR; Tariq, M, 1997) |
| "In rats with yeast-induced hyperalgesia, JTE-522 showed a dose-dependent antinociceptive effect (ED50: 4." | 1.30 | Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats. ( Masaki, M; Matsushita, M; Tanaka, T; Wakitani, K; Yagi, Y, 1997) |
| "Dopexamine is a specific dopaminergic and beta2-adrenergic agonist." | 1.30 | Indomethacin-induced reduction in neonatal piglet mesenteric blood flow is blunted by dopexamine. ( Choe, EU; Ferrara, JJ; Flint, LM; Mero, KA, 1998) |
| "Indomethacin was associated with electron microscopy changes suggestive of uncoupling in 60%-70% of enterocytes examined, whereas nimesulide affected 10%-30% of enterocytes, depending on the dose." | 1.30 | Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. ( Bjarnason, I; Foster, R; Jacob, M; Mahmud, T; Rafi, S; Roseth, A; Sigthorsson, G; Simpson, R; Somasundaram, S; Tavares, I; Wrigglesworth, J, 1998) |
| "Oedema was induced by: a) AA (0." | 1.30 | Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation. ( González, R; Ledón, N; Romay, C, 1998) |
| "Synoviocytes from adjuvant arthritis rats released a higher level of interleukin (IL)-1 and tumor necrosis factor (TNF) than that from the normal, control group." | 1.30 | Effects of indomethacin on secretory function of synoviocytes from adjuvant arthritis rats. ( Chen, MZ; Wang, B, 1998) |
| "Sepsis was induced in 225-250 g male rats (Sprague Dawley) by implanting fecal pellets containing Escherichia coli (100-150 CFU) and Bacteroides fragilis (10(4) CFU) into the abdominal cavity." | 1.30 | Prostaglandin E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram-negative sepsis. ( Ahmad, S; Ahmed, Z; Choudhry, MA; Sayeed, MM, 1999) |
| "A condition similar to preeclampsia was induced by infusing pregnant rats with the nitric oxide synthase inhibitor N G -nitro- L -arginine methyl ester through subcutaneously implanted osmotic minipumps." | 1.30 | The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia. ( Buhimschi, I; Chwalisz, K; Garfield, RE; Liao, QP; Saade, GR; Zlatnik, MG, 1999) |
| "A new model of cachexia is described in which muscle protein metabolism related to the ubiquitin-proteasome pathway was investigated." | 1.30 | A new model of cancer cachexia: contribution of the ubiquitin-proteasome pathway. ( Brand, SJ; Coggins, MB; Destree, AT; Dick, LR; Elliott, PJ; Goldberg, AL; Huang, JQ; Lazarus, DD; Mazzola, LM; McCormack, TA; Pierce, JW; Read, MA; Solomon, V; Xu, B, 1999) |
| "When indomethacin was administered to mice deficient in CD18, intercellular adhesion molecule 1 (ICAM-1), or P-selectin, there were significant decreases in lesion scores compared with their C57BL/6 controls." | 1.30 | Indomethacin induced gastropathy in CD18, intercellular adhesion molecule 1, or P-selectin deficient mice. ( Anderson, DC; Fuseler, JW; Granger, DN; Grisham, MB; Morise, Z, 1999) |
| "Indomethacin treatment did not affect endothelium-dependent relaxation in the control solution but partially restored the response to ACh in elevated glucose." | 1.29 | Magnesium modulates endothelial dysfunction produced by elevated glucose incubation. ( Duhault, J; Félétou, M; Rasetti, C, 1994) |
| "Sepsis was induced by cecal ligation and puncture (CLP)." | 1.29 | Alterations of ex vivo vascular reactivity in intraperitoneal sepsis. ( Chen, SJ; Wu, CC; Yen, MH, 1994) |
| "Indomethacin treatment resulted in mucosal ulceration and granulocyte infiltration, and a corresponding inflammatory response in the mesentery, which was characterised by an increase in the number of adherent (eightfold) and emigrated (sixfold) leucocytes and a reduction (80%) in leucocyte rolling velocity." | 1.29 | Leucocyte-endothelial cell adhesion in a model of intestinal inflammation. ( Anderson, DC; Arndt, H; Granger, DN; Grisham, MB; Palitzsch, KD; Rusche, J, 1995) |
| "Etodolac was found to have no effect on 5-lipoxygenase activity." | 1.29 | Effect of anti-inflammatory agent etodolac on antigen-induced contractions of the trachea and lung parenchyma of guinea pigs. ( Hamada, K; Inoue, K; Kimura, K; Shibata, Y; Ueda, F, 1994) |
| "carrageenin oedema and adjuvant arthritis." | 1.29 | Hyaluronic acid modulates acute and chronic inflammation. ( Di Rosa, M; Ialenti, A, 1994) |
| "Pain was induced by intraplantar injection of carrageenan (3 mg) into the hind paw of rats." | 1.29 | Antinociceptive properties of protein C in a model of inflammatory hyperalgesia in rats. ( Pichler, L; Schramm, W; Schwarz, HP; Ulrich, W; Varadi, K, 1995) |
| "Pretreatment with cisapride (0." | 1.29 | Protective effect of cisapride against indomethacin-induced obstruction of the gastric mucosal hemodynamics in rats. ( Ishii, A; Karasawa, A; Kitazawa, T; Ogihara, T; Sato, N; Yokoyama, T, 1994) |
| " Indomethacin given at therapeutic dosage before asphyxia/reventilation decreased superoxide anion production to 3 +/- 1 pmol NBT/mm2 per 20 min, values not significantly different from the control group and from piglets pretreated with oxypurinol at a dose of 50 mg/kg i." | 1.29 | Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose. ( Bada, HS; Busija, DW; Korones, SB; Leffler, CW; Pourcyrous, M, 1993) |
| " The results demonstrated that, while indomethacin is effective in decreasing the formation of heterotopic bone, piroxicam--when used in the dosage previously demonstrated to have no deleterious effect on healing bone--is not." | 1.29 | Effect of two nonsteroidal antiinflammatory drugs on heterotopic bone formation in a rabbit model. ( Fakhouri, AJ; Moed, BR; Nallamothu, B; Resnick, RB; Wagner, RA, 1994) |
| "Indomethacin was still effective in the continuous treatment group; however, resorption was distinctly higher than in the rats treated for four days." | 1.29 | Dose-effect and evidence of escape of inhibition after indomethacin treatment in a synchronized model of bone resorption. ( Leroux, P; Saffar, JL, 1993) |
| "Misoprostol treatment resulted in a significant reduction in the extent of indomethacin-induced antral ulceration, but ranitidine had no effect." | 1.29 | Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer. ( McKnight, GW; Wallace, JL, 1993) |
| "Gram-negative sepsis/septic shock in the newborn continues to be a major medical problem, causing high mortality." | 1.29 | Lipopolysaccharide alters suckling rat liver glycogenolysis. ( Goto, M; Goto, MP; Hurley, RM; Picken, M; Zeller, WP, 1993) |
| "Pretreatment with indomethacin did not result in improved fetal survival." | 1.29 | A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy. ( Gibbs, RS; Heddleston, L; McDuffie, RS, 1993) |
| "Acetic acid colitis was induced 24 hr before enzyme inhibition began." | 1.29 | Effects of cyclooxygenase and lipoxygenase inhibition on eicosanoids and healing of acetic acid colitis in rats. ( Guth, E; Guth, PH; LeDuc, LE; Reedy, T; Su, KC, 1993) |
| "Indomethacin was used for cyclooxygenase blockade and nordihydroguaiaretic acid was used to evaluate lipoxygenase inhibition." | 1.29 | Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism. ( Donovan, PK; Feinberg, BB; Gonik, B; Loftin, KC; Tan, NS, 1993) |
| "Ketotifen is an anti-allergic agent that was recently shown to prevent experimental gastric and colonic mucosal injury." | 1.29 | Ketotifen is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Karmeli, F; Marcus, H; Weizen, T; Zahavi, I, 1996) |
| "This hyperemia was reduced by L-NMMA but not by 8-PT." | 1.29 | Role of adenosine and nitric oxide in the hyperemic response to superficial and deep gastric mucosal injury and H+ back-diffusion in cats. ( Gislason, H; Svanes, K; Sørbye, H; Varhaug, P; Waldum, HL, 1996) |
| "The treatment with flurbiprofen and indomethacin administered subcutaneously every 12 hours, commenced on the day of S-antigen injection and was continued until the termination of the experiment (12 days)." | 1.28 | Modulation of immune responses by cyclo-oxygenase inhibitors during intraocular inflammation. ( Bhattacherjee, P; Jaramillo, A; Paterson, CA; Sonnenfeld, G, 1992) |
| "Acute and chronic sialoadenitis were induced in ovalbumin-immunized guinea pigs by a single or repeated (once a day for 5 days) instillation of antigen into the parotid gland via the parotid duct." | 1.28 | Experimental models of acute and chronic sialoadenitis in the guinea pig. ( Aonuma, S; Mikami, T; Miyasaka, K; Miyazawa, K, 1992) |
| "Severe necrotizing pancreatitis is accompanied by release of hemorrhagic ascites fluid (HAF), which is thought to be related to the occurrence and frequency of cardiocirculatory and pulmonary failure as a consequence of acute pancreatitis." | 1.28 | Hemodynamic effects following intraperitoneal infusion of pancreatic ascites fluid. ( Kerner, T; Lehnert, P; Schweiberer, L; Vierl, M; Vollmar, B; Waldner, H, 1992) |
| "Treatment with indomethacin could only abrogate the effects of nanogram doses of rIL-1 beta." | 1.28 | In-vivo administration of interleukin 1 both enhances and suppresses contact sensitivity in the mouse. ( Bäck, O; Linna, J, 1992) |
| " WCM stimulated adenylate cyclase in osteoblast like cells, the dose-response curve paralleling that of hPTHrP(1-34)." | 1.28 | Osteolytic activity of Walker carcinosarcoma 256 is due to parathyroid hormone-related protein (PTHrP). ( Grohe, U; Krieg, P; Lempert, UG; Maurer, E; Minne, HW; Rappel, S; Scharla, SH; Ziegler, R, 1991) |
| "Pretreatment with indomethacin to suppress mucosal generation of prostaglandin or the removal of salivary glands to eliminate the endogenous source of epidermal growth factor failed to affect sucralfate-induced gastroprotection." | 1.28 | Role of acid milieu in the gastroprotective and ulcer-healing activity of sucralfate. ( Brzozowski, T; Drozdowicz, D; Garlicki, J; Konturek, SJ; Majka, J; Pytko-Polonczyk, J, 1991) |
| " Our data suggest that both the route of drug administration and dosing regimen employed affect the antiinflammatory potency and/or efficacy of compounds on colitis induced by acetic acid in the rat." | 1.28 | Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. ( Bostwick, JS; Decktor, DL; Fitzpatrick, LR; Pendleton, RG; Renzetti, M, 1990) |
| "A new bone resorption model was developed by using living bone substrates and devitalized bones for isolated osteoclasts to act on." | 1.28 | Different resorption modes on living and devitalized bones by isolated osteoclasts in vitro. The effects of TIMP, E-64, and TGF-alpha. ( Shimizu, H, 1990) |
| "Indomethacin treatment inhibited PG synthesis in all BDL groups but only decreased the inflammation score in the 6 and 24 hour BDL groups." | 1.28 | Common bile ligation in the rabbit: an appropriate model for investigating the relationship of endogenous gallbladder prostanoid synthesis with evolving acute inflammation. ( Bartula, LL; Haley-Russell, D; Myers, SI; Nabzdyk, W, 1990) |
| "Acute edematous pancreatitis was produced in rats by subcutaneous administration of caerulein." | 1.28 | Prevention by prostaglandins of caerulein-induced pancreatitis in rats. ( Kolbasa, KP; Lancaster, C; Lum, JT; Nezamis, JE; Olafsson, AS; Robert, A, 1989) |
| "The onset of ocular hypertension occurred within 15 min." | 1.28 | Argon laser-induced ocular hypertension: animal model of ocular inflammation. ( Gherezghiher, T; Koss, MC, 1989) |
| " Results show that the drug exhibiting almost no antiinflammatory activity in the rat at the dosage used, phenylbutazone, was the most powerful inhibitor of ossification." | 1.27 | Correlation between ossification and inflammation using a rat experimental model. ( de Medicis, R; Lussier, A, 1983) |
| "Tumor volume, metastasis, and determination of regression of primary tumor have been evaluated." | 1.27 | Nb rat prostate adenocarcinoma model androgen-sensitive tumor: metastasis control. ( Drago, JR; Fralisch, A; Weed, P, 1983) |
| "Arachidonic acid-induced pleurisy in the rat was evaluated for testing inhibitors of arachidonic acid (AA) metabolism." | 1.27 | Arachidonic acid-induced pleurisy (ARIP): an in vivo model for testing 5-lipoxygenase inhibition. ( Boctor, AM; Burke, C; Hovinga, ME, 1987) |
| "Pretreatment with indomethacin (5 mg/kg iv) markedly reduced postischemia SOD-inhibitable NBT reduction (2." | 1.27 | Postischemic generation of superoxide anion by newborn pig brain. ( Armstead, WM; Busija, DW; Leffler, CW; Mirro, R, 1988) |
| "Inflammation was induced in the six-day air pouch either with the non-immune irritant carrageenan or the immune irritant Bordetella pertussis." | 1.27 | The effect of anti-inflammatory and rheumatoid disease modifying drugs on prolonged immune and non-immune inflammation in the six-day air pouch of rats. ( Al-Duaij, AY; Sedgwick, AD; Willoughby, DA, 1986) |
| "Treatment with indomethacin substantially reduced the levels of PGs, particularly PGE2 in tumor tissue, inhibited the tumor growth, particularly the early stage of cell proliferation, prolonged the survival time, eliminated tumors in the abdominal cavity, and inhibited metastatic tumor recurrence after surgery." | 1.27 | [Anti-cancer treatment with prostaglandin synthetase inhibitor in animal models]. ( Masuda, T; Nagasawa, O; Narisawa, T; Niwa, M; Ogata, N; Takahashi, M, 1986) |
| " In this model no effect of the receptor site antagonist was noted, but due to the short half-life of this compound, a different dosing schedule may be needed before its efficacy can be determined." | 1.27 | Group B streptococcal (GBSS) newborn septic shock model: the role of prostaglandins. ( Miller, MK; Pan, J; Short, BL, 1988) |
| " Chronic administration of DOCA (1 mg/kg s." | 1.27 | Induction, prevention and mechanisms of contrast media-induced acute renal failure. ( Jackson, BA; Natarajan, LA; Ott, CE; Vari, RC; Whitescarver, SA, 1988) |
| "Indomethacin pretreatment exaggerated cefotaxime and desacetylcefotaxime accumulation in the obstructed kidney of the UUO model, indicating that this drug inhibits renal elimination of cefotaxime when urinary tract obstruction exists." | 1.27 | Serum and renal tissue concentrations of cefotaxime in urinary tract obstruction in rabbits. ( Tago, K; Ueno, A; Yabusaki, N, 1988) |
| "A rabbit model of septic shock was used to determine if myocardial dysfunction is a common component of shock due to diverse neonatal pathogens, and prostaglandins modulate septic myocardial dysfunction." | 1.27 | The comparison of myocardial dysfunction in three forms of experimental septic shock. ( Boerth, RC; Chartrand, SA; Olson, RD; Peevy, KJ; Reed, T, 1986) |
| " During the second phase, after 24 h, edema was more pronounced, presented a clear dose-response relationship and peaked at 72 h after injection." | 1.27 | Mouse paw edema. A new model for inflammation? ( Assreuy-Filho, J; Cordeiro, RS; Cunha, FQ; Flores, CA; Henriques, MG; Martins, MA; Silva, PM, 1987) |
| "Indomethacin pretreatment did not significantly augment the duodenal lesions induced by mepirizole or cysteamine, but did augment the gastric lesions induced by these compounds." | 1.27 | Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin. ( Kuwahara, Y; Okabe, S; Tanaka, H, 1986) |
| "Thus, we sought to induce an oxidant lung injury and to prevent such injury by inhibiting lipoxygenase pathway or by blocking leukotriene action." | 1.27 | Leukotriene inhibitors attenuate rat lung injury induced by hydrogen peroxide. ( Burghuber, OC; Henson, JE; Henson, PM; Mathias, MM; Murphy, RC; Reeves, JT; Strife, RJ; Voelkel, NF; Zirrolli, J, 1985) |
| "Aspirin treatment however may be a precipitating factor when associated with other abnormalities of platelet function." | 1.26 | Bleeding time in rats: a comparison of different experimental conditions. ( de Gaetano, G; Dejana, E; Villa, S, 1982) |
| "In rat carrageenin pleurisy, dexamethasone (0." | 1.26 | Comparison of the anti-inflammatory effects of dexamethasone, indomethacin and BW755C on carrageenin-induced pleurisy in rats. ( Mikami, T; Miyasaka, K, 1982) |
| "Ibuprofen was more effective than indomethacin in the high mortality model (lethal dose for 90% survival of group)." | 1.26 | Improved survival in the suckling rat model of group B streptococcal sepsis after treatment with nonsteroidal anti-inflammatory drugs. ( Fletcher, JR; Miller, MK; Short, BL, 1982) |
| "In 67 dogs with a 60-80% coronary stenosis produced by an external constricting plastic ring, blood flow measured with an electromagnetic flowmeter showed cyclical flow reductions of varying magnitude and duration, and then an abrupt return to control flow." | 1.26 | Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? ( Folts, JD; Gallagher, K; Rowe, GG, 1982) |
| "Animals were subjected to hypovolemic shock by withdrawing volumes of blood necessary to maintain a systolic pressure of 30-40 mm Hg for 105-110 min." | 1.26 | Hypovolemic models of acute tubular necrosis in the rat kidney. ( Bulger, RE; Dobyan, DC; Nagle, RB, 1977) |
| " In animals pretreated by anti-inflammatory drugs in toxic doses an earlier development of ulceration was observed by distention with acid." | 1.26 | Distention ulcer as a model for testing of drugs for ulcerogenic side effects. ( Szelenyi, I; Thiemer, K, 1978) |
| "Rats treated with indomethacin showed a marked decrease of proteinuria (tested by the 3% sulfosalicylic aicd method) and a clear ultrastructural picture of hyperplasia and hypertrophy of podocytes." | 1.26 | Indomethacin and lysine acetylsalicylate in rats with autologous nephrotoxic serum nephritis. Biochemical and morphological studies. ( Cioffi, A; Conte, F; Di Belgiojoso, GB; Donati, MB; Saruggia, M; Sessa, A, 1978) |
| "Aspirin pretreatment prevented the ocular response following the intravenous injection of 10 mug per kilogram of endotoxin, but had no effect following 100 mug per kilogram." | 1.26 | The effects of aspirin and indomethacin on the ocular response to circulating bacterial endotoxin in the rabbit. ( Howes, EL; McKay, DG, 1976) |
| "Pretreatment with indomethacin markedly attenuated both the hemodynamic changes and the rise in plasma renin activity caused by endotoxin administration." | 1.26 | Prostaglandins and the renin-angiotensin system in canine endotoxemia. ( Feldhaus, RA; Isakson, PC; McKnight, RC; Needleman, P; Raz, A; Shofer, F, 1977) |
| "Osteoarthritis was induced in the rabbit by a single intra-articular injection of 0." | 1.26 | Activity of anti-inflammatory drugs on an experimental model of osteoarthritis. ( Cros, J; Guiraud, R; Marcelon, G, 1976) |
| "Oedema was measured after the challenging injection." | 1.26 | Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs. ( Arrigoni-Martelli, E; Bramm, E; Dieppe, PA; Huskisson, EC; Willoughby, DA, 1976) |
| " Dosing with D-penicillamine (25 mg/kg) and levamisole (5 mg/kg) at the time of challenge produced a significant enhancement of the reaction." | 1.26 | Pertussis vaccine pleurisy: a model of delayed hypersensitivity. ( Arrigoni-Martelli, E; Dieppe, PA; Huskisson, EC; Willoughby, DA, 1976) |
| "The production of bone resorption-stimulating activity and PGE2 by VX2 cells in culture were both inhibited by indomethacin (100 ng/ml)." | 1.25 | Hypercalcemia and tumor-prostaglandins: the VX2 carcinoma model in the rabbit. ( Franklin, R; Levine, L; Tashjian, AH; Voelkel, EF; Wasserman, E, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 179 (17.11) | 18.7374 |
| 1990's | 190 (18.16) | 18.2507 |
| 2000's | 341 (32.60) | 29.6817 |
| 2010's | 292 (27.92) | 24.3611 |
| 2020's | 44 (4.21) | 2.80 |
| Authors | Studies |
|---|---|
| Walsh, DA | 1 |
| Sleevi, MC | 1 |
| Sancilio, LF | 1 |
| Wilkerson, WW | 1 |
| Galbraith, W | 1 |
| Gans-Brangs, K | 1 |
| Grubb, M | 1 |
| Hewes, WE | 1 |
| Jaffee, B | 1 |
| Kenney, JP | 1 |
| Kerr, J | 1 |
| Wong, N | 1 |
| Lages, AS | 1 |
| Silva, KC | 1 |
| Miranda, AL | 1 |
| Fraga, CA | 2 |
| Barreiro, EJ | 2 |
| Shin, SS | 1 |
| Noh, MS | 1 |
| Byun, YJ | 1 |
| Choi, JK | 2 |
| Kim, JY | 1 |
| Lim, KM | 1 |
| Ha, JY | 1 |
| Kim, JK | 1 |
| Lee, CH | 3 |
| Chung, S | 1 |
| Delgado, G | 1 |
| del Socorro Olivares, M | 1 |
| Chávez, MI | 1 |
| Ramírez-Apan, T | 1 |
| Linares, E | 1 |
| Bye, R | 1 |
| Espinosa-García, FJ | 1 |
| Feixas, J | 1 |
| Jiménez, JM | 1 |
| Godessart, N | 1 |
| Puig, C | 1 |
| Soca, L | 1 |
| Crespo, MI | 1 |
| Cardoso, CR | 1 |
| de Brito, FC | 1 |
| da Silva, KC | 1 |
| de Miranda, AL | 1 |
| Fujita, M | 1 |
| Seki, T | 1 |
| Ikeda, N | 1 |
| Ohtsuki, S | 1 |
| Kikkawa, T | 1 |
| Mori, S | 1 |
| Hori, S | 1 |
| Takanaga, H | 1 |
| Otagiri, M | 2 |
| Terasaki, T | 1 |
| Doulgkeris, CM | 1 |
| Galanakis, D | 1 |
| Kourounakis, AP | 2 |
| Tsiakitzis, KC | 1 |
| Gavalas, AM | 1 |
| Eleftheriou, PT | 1 |
| Victoratos, P | 1 |
| Rekka, EA | 1 |
| Kourounakis, PN | 1 |
| Stock, N | 1 |
| Munoz, B | 1 |
| Wrigley, JD | 1 |
| Shearman, MS | 1 |
| Beher, D | 1 |
| Peachey, J | 1 |
| Williamson, TL | 1 |
| Bain, G | 1 |
| Chen, W | 3 |
| Jiang, X | 2 |
| St-Jacques, R | 1 |
| Prasit, P | 1 |
| Rios, MY | 1 |
| Aguilar-Guadarrama, AB | 1 |
| Barlow, JW | 1 |
| Walsh, JJ | 1 |
| Abouzid, K | 1 |
| Bekhit, SA | 1 |
| Liu, H | 3 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Van Cleemput, M | 1 |
| Cattoor, K | 1 |
| De Bosscher, K | 1 |
| Haegeman, G | 1 |
| De Keukeleire, D | 1 |
| Heyerick, A | 1 |
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Ispikoudi, M | 1 |
| Amvrazis, M | 1 |
| Kontogiorgis, C | 1 |
| Koumbis, AE | 1 |
| Litinas, KE | 1 |
| Hadjipavlou-Litina, D | 1 |
| Fylaktakidou, KC | 1 |
| Maldonado, E | 2 |
| Díaz-Arumir, H | 1 |
| Toscano, RA | 1 |
| Martínez, M | 2 |
| Reina, E | 1 |
| Puentes, C | 1 |
| Rojas, J | 1 |
| García, J | 1 |
| Ramos, FA | 1 |
| Castellanos, L | 1 |
| Aragón, M | 1 |
| Ospina, LF | 1 |
| Liu, W | 2 |
| Zhou, J | 1 |
| Zhang, T | 2 |
| Zhu, H | 2 |
| Qian, H | 1 |
| Zhang, H | 1 |
| Huang, W | 2 |
| Gust, R | 1 |
| Bano, S | 1 |
| Javed, K | 1 |
| Ahmad, S | 2 |
| Rathish, IG | 1 |
| Singh, S | 4 |
| Chaitanya, M | 1 |
| Arunasree, KM | 1 |
| Alam, MS | 2 |
| Borghi, SM | 1 |
| Carvalho, TT | 1 |
| Staurengo-Ferrari, L | 1 |
| Hohmann, MS | 1 |
| Pinge-Filho, P | 1 |
| Casagrande, R | 3 |
| Verri, WA | 3 |
| Aggarwal, R | 1 |
| Bansal, A | 1 |
| Rozas, I | 1 |
| Kelly, B | 1 |
| Kaushik, P | 1 |
| Kaushik, D | 1 |
| Arciniegas, A | 1 |
| González, K | 1 |
| Pérez-Castorena, AL | 2 |
| Nieto-Camacho, A | 1 |
| Villaseñor, JL | 1 |
| Romo de Vivar, A | 1 |
| Sarnpitak, P | 1 |
| Mujumdar, P | 1 |
| Morisseau, C | 1 |
| Hwang, SH | 1 |
| Hammock, B | 1 |
| Iurchenko, V | 1 |
| Zozulya, S | 1 |
| Gavalas, A | 1 |
| Geronikaki, A | 1 |
| Ivanenkov, Y | 1 |
| Krasavin, M | 1 |
| Lima, Mda S | 1 |
| Evangelista, AF | 1 |
| Santos, GG | 1 |
| Ribeiro, IM | 1 |
| Tomassini, TC | 1 |
| Pereira Soares, MB | 1 |
| Villarreal, CF | 2 |
| Özdemir, A | 1 |
| Altintop, MD | 1 |
| Turan-Zitouni, G | 1 |
| Çiftçi, GA | 1 |
| Ertorun, İ | 1 |
| Alataş, Ö | 1 |
| Kaplancikli, ZA | 1 |
| Romero, Y | 1 |
| Alonso-Castro, AJ | 2 |
| Zapata-Morales, JR | 1 |
| Hernández-Munive, A | 1 |
| Campos-Xolalpa, N | 1 |
| Pérez-Gutiérrez, S | 1 |
| Pérez-González, C | 1 |
| Sarigol, D | 1 |
| Uzgoren-Baran, A | 1 |
| Tel, BC | 1 |
| Somuncuoglu, EI | 1 |
| Kazkayasi, I | 1 |
| Ozadali-Sari, K | 1 |
| Unsal-Tan, O | 1 |
| Okay, G | 1 |
| Ertan, M | 1 |
| Tozkoparan, B | 1 |
| Banerjee, AG | 1 |
| Das, N | 1 |
| Shengule, SA | 1 |
| Srivastava, RS | 1 |
| Shrivastava, SK | 1 |
| Yang, J | 1 |
| Cai, HD | 1 |
| Zeng, YL | 1 |
| Chen, ZH | 1 |
| Fang, MH | 1 |
| Su, YP | 1 |
| Huang, HH | 1 |
| Xu, Y | 2 |
| Yu, CX | 1 |
| Svouraki, A | 1 |
| Garscha, U | 1 |
| Kouloura, E | 1 |
| Pace, S | 1 |
| Pergola, C | 1 |
| Krauth, V | 1 |
| Rossi, A | 1 |
| Sautebin, L | 1 |
| Halabalaki, M | 1 |
| Werz, O | 1 |
| Gaboriaud-Kolar, N | 1 |
| Skaltsounis, AL | 1 |
| Katselou, MG | 1 |
| Matralis, AN | 1 |
| Meira, CS | 1 |
| Dos Santos Filho, JM | 1 |
| Sousa, CC | 1 |
| Anjos, PS | 1 |
| Cerqueira, JV | 1 |
| Dias Neto, HA | 1 |
| da Silveira, RG | 1 |
| Russo, HM | 1 |
| Wolfender, JL | 1 |
| Queiroz, EF | 1 |
| Moreira, DRM | 1 |
| Soares, MBP | 1 |
| Singh, G | 2 |
| Bhatti, R | 1 |
| Gupta, M | 1 |
| Kumar, A | 2 |
| Sharma, A | 1 |
| Singh Ishar, MP | 1 |
| Kumar, RS | 1 |
| Antonisamy, P | 1 |
| Almansour, AI | 1 |
| Arumugam, N | 1 |
| Periyasami, G | 1 |
| Altaf, M | 1 |
| Kim, HR | 1 |
| Kwon, KB | 1 |
| Shi, JB | 1 |
| Chen, LZ | 1 |
| Wang, BS | 1 |
| Huang, X | 1 |
| Jiao, MM | 1 |
| Liu, MM | 1 |
| Tang, WJ | 1 |
| Liu, XH | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 2 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| He, LY | 1 |
| Zhang, SS | 1 |
| Peng, DX | 1 |
| Guan, LP | 1 |
| Wang, SH | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Said, MF | 1 |
| Georgey, HH | 1 |
| Mohammed, ER | 1 |
| Wang, H | 3 |
| Cui, E | 1 |
| Li, J | 4 |
| Ma, X | 1 |
| Du, S | 1 |
| Qian, S | 1 |
| Du, L | 1 |
| Fagundes, FL | 1 |
| Pereira, QC | 1 |
| Zarricueta, ML | 1 |
| Dos Santos, RC | 1 |
| Aleid, IS | 1 |
| Alfheeaid, HA | 1 |
| Aljutaily, T | 1 |
| Alhomaid, RM | 1 |
| Alharbi, HF | 1 |
| Althwab, SA | 1 |
| Abdel-Rahman, HA | 1 |
| AlGeffari, MA | 1 |
| Barakat, H | 1 |
| Liu, F | 1 |
| Wu, Q | 1 |
| Han, W | 1 |
| Laster, K | 1 |
| Hu, Y | 1 |
| Ma, F | 1 |
| Chen, H | 2 |
| Tian, X | 1 |
| Qiao, Y | 1 |
| Kim, DJ | 1 |
| Dong, Z | 1 |
| Liu, K | 1 |
| Sallam, AM | 1 |
| Darwish, SF | 1 |
| El-Dakroury, WA | 1 |
| Radwan, E | 1 |
| Jindal, A | 1 |
| Singh, R | 3 |
| Tomar, S | 1 |
| Dureja, J | 1 |
| Karan, M | 1 |
| Chadha, R | 1 |
| Cole, LK | 1 |
| Sparagna, GC | 1 |
| Dolinsky, VW | 1 |
| Hatch, GM | 1 |
| Kiratipaiboon, C | 1 |
| Dasuni Wasana, PW | 1 |
| Sukrong, S | 1 |
| Ruangrungsri, N | 1 |
| Towiwat, P | 1 |
| Mesripour, A | 1 |
| Shahnooshi, S | 1 |
| Hajhashemi, V | 1 |
| Butenas, ALE | 1 |
| Hopkins, TD | 1 |
| Rollins, KS | 1 |
| Felice, KP | 1 |
| Copp, SW | 1 |
| Xia, X | 1 |
| Chan, KF | 1 |
| Wong, GTY | 1 |
| Wang, P | 1 |
| Liu, L | 1 |
| Yeung, BPM | 1 |
| Ng, EKW | 1 |
| Lau, JYW | 1 |
| Chiu, PWY | 1 |
| Shanmugam, S | 1 |
| Thangaraj, P | 1 |
| Dos Santos Lima, B | 1 |
| Trindade, GGG | 1 |
| Narain, N | 1 |
| Mara de Oliveira E Silva, A | 1 |
| Santin, JR | 3 |
| Broering, MF | 1 |
| Serafini, MR | 1 |
| Quintans-Júnior, LJ | 3 |
| Antunes de Souza Araújo, A | 1 |
| Richartz, N | 1 |
| Duthil, E | 1 |
| Ford, A | 1 |
| Naderi, EH | 1 |
| Bhagwat, S | 1 |
| Gilljam, KM | 1 |
| Burman, MM | 1 |
| Ruud, E | 1 |
| Blomhoff, HK | 1 |
| Skah, S | 1 |
| Sugimura, N | 2 |
| Otani, K | 5 |
| Watanabe, T | 5 |
| Nakatsu, G | 1 |
| Shimada, S | 2 |
| Fujimoto, K | 1 |
| Nadatani, Y | 4 |
| Hosomi, S | 3 |
| Tanaka, F | 3 |
| Kamata, N | 3 |
| Taira, K | 3 |
| Nagami, Y | 3 |
| Tanigawa, T | 5 |
| Uematsu, S | 1 |
| Fujiwara, Y | 5 |
| Suda, W | 1 |
| Nakata, A | 2 |
| Matsumoto, Y | 1 |
| Kosaka, S | 1 |
| Higashimori, A | 3 |
| Yamagami, H | 4 |
| Hattori, M | 1 |
| Charlton, JR | 2 |
| Baldelomar, EJ | 2 |
| deRonde, KA | 1 |
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| Charlton, NP | 1 |
| Criswell, SJ | 1 |
| Hyatt, DM | 1 |
| Nam, S | 1 |
| Pearl, V | 1 |
| Bennett, KM | 2 |
| Li, QJ | 1 |
| Wang, ZG | 1 |
| Xie, Y | 2 |
| Liu, Q | 2 |
| Hu, HL | 1 |
| Gao, YX | 1 |
| Lapp, R | 1 |
| Röttgen, V | 1 |
| Viergutz, T | 1 |
| Weitzel, JM | 1 |
| Vernunft, A | 1 |
| Chen, JM | 1 |
| Liu, KC | 1 |
| Yeh, WL | 1 |
| Chen, JC | 1 |
| Liu, SJ | 1 |
| El Naggar, EE | 1 |
| Mohamed, EA | 1 |
| Borg, TM | 1 |
| El-Sheakh, AR | 1 |
| Hamed, MF | 1 |
| Cao, L | 1 |
| Li, X | 1 |
| Xu, R | 1 |
| Yao, K | 1 |
| Yang, W | 1 |
| Wang, G | 1 |
| Zhang, J | 1 |
| Satoh, H | 4 |
| Akiba, Y | 1 |
| Urushidani, T | 2 |
| Pineda-Peña, EA | 2 |
| Orona-Ortiz, A | 1 |
| Velázquez-Moyado, JA | 1 |
| Tavares-Carvalho, JC | 1 |
| Chávez-Piña, AE | 3 |
| Balderas-López, JL | 1 |
| Navarrete, A | 1 |
| Saleem, M | 1 |
| Asif, M | 1 |
| Parveen, A | 1 |
| Yaseen, HS | 1 |
| Saadullah, M | 1 |
| Bashir, A | 1 |
| Asif, J | 1 |
| Arif, M | 1 |
| Khan, IU | 1 |
| Khan, RU | 1 |
| Ahmed, OAA | 2 |
| Fahmy, UA | 2 |
| Bakhaidar, R | 1 |
| El-Moselhy, MA | 1 |
| Alfaleh, MA | 1 |
| Ahmed, AF | 1 |
| Hammad, ASA | 1 |
| Aldawsari, H | 1 |
| Alhakamy, NA | 2 |
| Medeiros, P | 1 |
| Dos Santos, IR | 1 |
| Medeiros, AC | 1 |
| da Silva, JA | 1 |
| Ferreira, SH | 3 |
| de Freitas, RL | 1 |
| Coimbra, NC | 1 |
| Song, H | 1 |
| Hou, X | 1 |
| Zeng, M | 1 |
| Chen, X | 2 |
| Yang, T | 2 |
| Xu, F | 1 |
| Peng, J | 1 |
| Peng, Q | 1 |
| Cai, X | 1 |
| Yu, R | 1 |
| Cervantes-García, D | 1 |
| Bahena-Delgado, AI | 1 |
| Jiménez, M | 1 |
| Córdova-Dávalos, LE | 1 |
| Ruiz-Esparza Palacios, V | 1 |
| Sánchez-Alemán, E | 1 |
| Martínez-Saldaña, MC | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Study of Orally Administrated JBM-TC4 for the Prevention of Acute Radiation-induced Dermatitis in Breast Cancer Patients[NCT02289365] | Phase 2 | 120 participants (Actual) | Interventional | 2014-11-30 | Enrolling by invitation | ||
| Thermoregulation Among Individuals With First-episode Psychosis[NCT04369677] | 20 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| A Multicenter, Randomized, Open-label, Controlled Trial to Assess Effectiveness and Safety of Rhea Health Tone® as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia[NCT04627519] | 85 participants (Actual) | Interventional | 2020-12-09 | Active, not recruiting | |||
| Effects of Lavender Aromatherapy and Cold Application on Pain During Drain Removal[NCT04798040] | 121 participants (Actual) | Interventional | 2021-09-01 | Completed | |||
| Elderly Patients With Dementia in the Department of Acute Geriatrics: Pilot Study, Monocentric, Randomized Use of Aromatherapy as a Complementary Treatment to Psychopharmacotherapy in Psychological Disorders and BPSD Behavior[NCT03662360] | 32 participants (Actual) | Interventional | 2018-05-20 | Completed | |||
| A Randomized Prospective Placebo-Controlled Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients[NCT01837966] | 93 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Evaluation of Free Aminoacids in Saliva as A Diagnostic Biomarker of Periodontal Disease[NCT04642716] | 60 participants (Actual) | Interventional | 2015-04-20 | Completed | |||
| The Effect of Perioperative Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection[NCT01612975] | Phase 2 | 7 participants (Actual) | Interventional | 2014-04-30 | Terminated (stopped due to Recruitment futile) | ||
| The Effect of Resistant Starch Consumption on Zinc Hemostasis in Malawian Children at Risk for Zinc Deficiency[NCT01811836] | 20 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| GpCRC Pediatric Gastroparesis Registry 2: Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants With Symptoms of Gastroparesis[NCT05981300] | 216 participants (Anticipated) | Observational [Patient Registry] | 2024-02-28 | Not yet recruiting | |||
| Biomarkers of Nonsteroidal Anti-Inflammatories[NCT00239746] | Phase 1 | 40 participants (Anticipated) | Interventional | 2005-10-31 | Active, not recruiting | ||
| Placebo-Controlled, Ascending Single-Dose Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of CHF 5074 in Healthy Young Male Subjects[NCT00954252] | Phase 1 | 84 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| A Randomized, Placebo-Controlled Trial of ONO-4819CD for Treatment of Mild to Moderate Ulcerative Colitis.[NCT00296556] | Phase 2 | 7 participants (Actual) | Interventional | 2006-02-28 | Terminated (stopped due to terminated) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Neuropsychiatric Inventory - Nursing Home Version (NPI-NH) test will characterize the neuropsychiatric and psychopathological symptoms of patients affected by dementia.~Events as delirium, anxiety, depression, etc. will be recorded by the frequency (from 0, absence, to 4, high frequency) and the seriousness (from 0, absence, to 3, high). The total score of the NPI-NH is given by the frequency x (multiply) seriousness (total score for each event has a range from 0 to 12). The patient final score will be given by the sum of the score of the 12 events. For each patient will be given a total score from 0 to 144.~NPI NH score has been collected in both control and aromatherapy groups at T1 and T3, in patients who needed and who did not needed Pro Re Nata." (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| T1 NPI score in patients do not need Pro Re Nata | T3 NPI score in patients needed Pro Re Nata | T3 NPI score in patients do not need Pro Re Nata | |
| GROUP A - Control Group | 21.81 | 32.87 | 20.00 |
| GROUP B - Aromatherapy Group | 25.93 | 16.5 | 7.25 |
NPI-NH assess the psychological distress in physicians, nurses and nursing assistants who managed the patients. It has a score from 0 (no discomfort) to score of 5 (extreme discomfort). The psychological distress is measured for each of the 12 events in the NPI-NH scale, for a total score from 0 to 60. (NCT03662360)
Timeframe: Time 1 (baseline) and Time 3 (day 7)
| Intervention | score on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T1 NPI NH physicians in pts with PRN | T1 NPI NH physicians in pts without PRN | T1 NPI NH nurses in pts with PRN | T1 NPI NH nurses in pts without PRN | T1 NPI NH nursing assistants in pts with PRN | T1 NPI NH nursing assistants in pts without PRN | T3 NPI NH physician in pts with PRN | T3 NPI NH physician in pts without PRN | T3 NPI NH nurses in pts with PRN | T3 NPI NH nurses in pts without PRN | T3 NPI NH nursing assistants in pts with PRN | T3 NPI NH nursing assistants in pts without PRN | |
| GROUP A - Control Group | 4.19 | 1.60 | 9.63 | 6.40 | 11.00 | 7.10 | 6.00 | 3.20 | 12.00 | 9.30 | 13.19 | 9.90 |
| GROUP B - Aromatherapy Group | 5.64 | 4.13 | 11.64 | 10.13 | 12.21 | 10.88 | 2.64 | 0.88 | 5.79 | 4.25 | 5.93 | 4.38 |
We hoped to show that lavender aroma therapy reduces preoperative anxiety in patients undergoing breast. The Trait subscale (STAI-TRAID) of the Spielberger State-Trait Anxiety Inventory was administered before and after 10 minutes of aromatherapy treatment pre-surgery. The TRAIT subscale contains 20 questions scored on a Likert scale from 1-4; item scores are summed for a total score ranging from 20 to 80, with higher scores indicating higher anxiety. Change in anxiety was calculated as the score pre-aromatherapy minus the score post-aromatherapy. Higher positive change scores indicate greater reductions in anxiety. (NCT01837966)
Timeframe: 20 minutes before surgery (pre aromatherapy) and 10 minutes before surgery (post aromatherapy)
| Intervention | units on a scale (Mean) |
|---|---|
| Lavender Oil | 0.89 |
| Placebo | .74 |
14 reviews available for indomethacin and Disease Models, Animal
| Article | Year |
|---|---|
Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.
Topics: Acids; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Central Nervous System; Disease Models | 2009 |
Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment.
Topics: Acetaminophen; Animals; Disease Models, Animal; Ductus Arteriosus, Patent; Genetic Predisposition to | 2018 |
Role of NO and other vascular mediators in the etiopathogenesis of necrotizing enterocolitis.
Topics: Age of Onset; Animals; Arginine; Catecholamines; Disease Models, Animal; Dogs; Endothelins; Enteroco | 2019 |
Animal migraine models for drug development: status and future perspectives.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drug Discovery; Forecasting; Humans; | 2013 |
Understanding intestinal vulnerability to perforation in the extremely low birth weight infant.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Communicable Diseases; Disease Models, Animal; Fem | 2009 |
Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Animals, Genetically Modified; Anti-Inflammator | 2005 |
Minimising neonatal brain injury: how research in the past five years has changed my clinical practice.
Topics: Animals; Birth Injuries; Brain Diseases; Dexamethasone; Disease Models, Animal; Ethamsylate; Humans; | 2007 |
Pharmacologic problems in shock research.
Topics: Adrenergic alpha-Antagonists; Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age | 1983 |
Necrotizing enterocolitis: a review of animal models.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Bacterial Physiological Phenomena; Blood Volume; Bre | 1984 |
Indomethacin in the management of elevated intracranial pressure: a review.
Topics: Animals; Body Temperature; Brain Edema; Cerebrovascular Circulation; Clinical Trials as Topic; Crani | 1997 |
The clinical, morphologic, and molecular changes in the ileum associated with early postnatal dexamethasone administration: from the baby's bowel to the researcher's bench.
Topics: Animals; Dexamethasone; Disease Models, Animal; Gastric Mucosa; Gestational Age; Humans; Ileum; Indo | 2001 |
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils].
Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer | 2001 |
Prostaglandin inhibitors in the treatment of nephrotic syndrome.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Humans; Indomethacin; Neph | 1991 |
[Clinical use of non-steroid anti-inflammatory agents].
Topics: Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Arthritis, Rheumatoid; Aspirin; Cell Mi | 1974 |
1032 other studies available for indomethacin and Disease Models, Animal
| Article | Year |
|---|---|
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chemical Phenomena; Chemistry | 1984 |
Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disease Models, Animal; D | 1994 |
Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal; | 1998 |
2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.
Topics: Animals; Arthritis, Experimental; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygena | 2001 |
Antiinflammatory constituents from Heterotheca inuloides.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Disease Models, Animal; Dose-Response | 2001 |
Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2001 |
Design, synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: a new class of anti-inflammatory and anti-platelet agents.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical | 2002 |
Synthesis and bioactivities of novel bicyclic thiophenes and 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.
Topics: Animals; Arthritis, Experimental; Bridged Bicyclo Compounds; Disease Models, Animal; Inhibitory Conc | 2002 |
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Ma | 2004 |
Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antioxidants; Arthritis; | 2006 |
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, N | 2006 |
Nitrogen-containing phorbol esters from Croton ciliatoglandulifer and their effects on cyclooxygenases-1 and -2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Croton; Cyclooxygenase 1; Cyclooxygenase 2; Cycloo | 2006 |
Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds.
Topics: Amides; Amines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Disease Models, | 2008 |
Novel anti-inflammatory agents based on pyridazinone scaffold; design, synthesis and in vivo activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Carrageenan; Cyclooxygenase 2; Cycl | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Edema; Female | 2010 |
Lupane triterpenes with a δ-lactone at ring E, from Lippia mexicana.
Topics: Animals; Anti-Inflammatory Agents; Crystallography, X-Ray; Disease Models, Animal; Edema; Lactones; | 2010 |
Fuscoside E: a strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca.
Topics: Animals; Anthozoa; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacillus; Biologi | 2011 |
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Breast Neoplasms; Cell L | 2012 |
Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Chalcones; Cyclooxygenase | 2013 |
Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apigenin; Benzoquinones; Capsaicin; Carrageenan; Cyto | 2013 |
Synthesis, biological evaluation and molecular modeling study of 5-trifluoromethyl-Δ²-pyrazoline and isomeric 5/3-trifluoromethylpyrazole derivatives as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2013 |
Sesquiterpenoids from Pittocaulon filare.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Disease Models, Animal; Edema; Glucosides; Indomethac | 2014 |
Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Car | 2014 |
Antinociceptive properties of physalins from Physalis angulata.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Freund's Adjuvant; Hyp | 2014 |
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents.
Topics: Animals; Cell Survival; Chalcones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Di | 2015 |
Absolute configuration of labdane diterpenoids from Physalis nicandroides.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Crystallography, X-Ray; Disease Models, Animal; Di | 2015 |
Synthesis, antinociceptive and anti-inflammatory effects of porphyrins.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Exper | 2015 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; D | 2015 |
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cycloox | 2015 |
Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Cytokines; Disease Models, Animal | 2016 |
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Disease Models, Anima | 2017 |
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
Topics: Animals; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Disease Mod | 2017 |
Structural design, synthesis and substituent effect of hydrazone-N-acylhydrazones reveal potent immunomodulatory agents.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Crystallography, X-Ray; Dinoprostone; Disease Mode | 2018 |
Indolyl-isoxazolidines attenuate LPS-stimulated pro-inflammatory cytokines and increase survival in a mouse model of sepsis: Identification of potent lead.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Inflammation; Interleukin-6; | 2018 |
Functionalized spirooxindole-indolizine hybrids: Stereoselective green synthesis and evaluation of anti-inflammatory effect involving TNF-α and nitrite inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Crystallography, X-Ray; Disease Model | 2018 |
Novel Pyrazolo[4,3- d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Crystallography, X-Ray; Dimerization; Di | 2019 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Synthesis and evaluations of selective COX-2 inhibitory effects: Benzo[d]thiazol analogs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 | 2020 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; | 2021 |
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazol | 2022 |
Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation.
Topics: Acetic Acid; Animals; Anthocyanins; Antioxidants; Biomarkers; Cyclooxygenase 1; Disease Models, Anim | 2021 |
Gastroprotective Effects of
Topics: Actinidia; Animals; Anti-Ulcer Agents; Disease Models, Animal; Fruit; Gastric Mucosa; Indomethacin; | 2021 |
Targeting integrin αvβ3 with indomethacin inhibits patient-derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cell Surviva | 2021 |
Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biologica | 2021 |
Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies.
Topics: Alanine; Animals; Biological Availability; Biological Products; Carrageenan; Chemical Engineering; C | 2021 |
Altered cardiolipin metabolism is associated with cardiac mitochondrial dysfunction in pulmonary vascular remodeled perinatal rat pups.
Topics: Animals; Animals, Newborn; Cardiolipins; Disease Models, Animal; Female; Hypoxia; Indomethacin; Mito | 2022 |
Herbal root extracts in Ben-Cha-Moon-Yai remedy attenuated pain-like behaviors and inflammation through the opioid and prostaglandin systems.
Topics: Aegle; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; | 2022 |
Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Depression; Disease M | 2019 |
Investigation of the mechanisms of cyclooxygenase-mediated mechanoreflex sensitization in a rat model of simulated peripheral artery disease.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Femoral Artery; Ganglia, S | 2019 |
Mesenchymal stem cells promote healing of nonsteroidal anti-inflammatory drug-related peptic ulcer through paracrine actions in pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cell Transdifferentiation; Cul | 2019 |
Protective effects of flavonoid composition rich P. subpeltata Ortega. on indomethacin induced experimental ulcerative colitis in rat models of inflammatory bowel diseases.
Topics: Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Disease Models, Animal; Flavonoids; G | 2020 |
Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model.
Topics: Animals; Biomarkers; Bone Marrow; Cell Line, Tumor; Child; Child, Preschool; Cyclooxygenase Inhibito | 2019 |
High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium; Dextrans; Diet, High-Fat; Disease | 2019 |
Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii.
Topics: Animals; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transplantation; High-Throughput Nucleo | 2019 |
Nephron loss detected by MRI following neonatal acute kidney injury in rabbits.
Topics: Acute Kidney Injury; Animals; Animals, Newborn; Cations; Disease Models, Animal; Ferritins; Gentamic | 2020 |
Mechanistic evaluation of gastro-protective effects of KangFuXinYe on indomethacin-induced gastric damage in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Gastric Mucosa; Gastrointestinal Agents; Indomethacin; | 2020 |
Induction of cystic ovarian follicles (COFs) in cattle by using an intrafollicular injection of indomethacin.
Topics: Animals; Cattle; Cyclooxygenase Inhibitors; Dinoprost; Disease Models, Animal; Estrus Synchronizatio | 2020 |
Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies.
Topics: 3T3 Cells; Analgesics; Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Compoundin | 2020 |
Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Cytoprotection; Diseas | 2020 |
DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dual Oxidases; Duloxetine Hydrochloride; Gas | 2020 |
Proton Pump Inhibitors Prevent Gastric Antral Ulcers Induced by NSAIDs via Activation of Capsaicin-Sensitive Afferent Nerves in Mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Disease Models, Animal; Gastric Emptyin | 2020 |
Anti-inflammatory, antioxidant, and gaso-protective mechanism of 3α-hydroxymasticadienoic acid and diligustilide combination on indomethacin gastric damage.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Dinoprostone; Disease Models, An | 2020 |
Investigation of in vivo anti-inflammatory and anti-angiogenic attributes of coumarin-rich ethanolic extract of Melilotus indicus.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Coumarins; Disease Models, Animal; Dose- | 2021 |
Pumpkin Oil-Based Nanostructured Lipid Carrier System for Antiulcer Effect in NSAID-Induced Gastric Ulcer Model in Rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cucurbita; Disease Models, Animal; Drug Carriers; | 2020 |
Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury.
Topics: Animals; Constriction; Disease Models, Animal; Indomethacin; Male; Neuralgia; Pain Measurement; Pain | 2020 |
Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway.
Topics: Animals; Anti-Ulcer Agents; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Gastric Mucosa | 2020 |
Glycomacropeptide Ameliorates Indomethacin-Induced Enteropathy in Rats by Modifying Intestinal Inflammation and Oxidative Stress.
Topics: Animals; Caseins; Chemokine CXCL1; Disease Models, Animal; Gene Expression Regulation; Humans; Indom | 2020 |
Mapping vascular and glomerular pathology in a rabbit model of neonatal acute kidney injury using MRI.
Topics: Acute Kidney Injury; Animals; Animals, Newborn; Disease Models, Animal; Gentamicins; Indomethacin; K | 2020 |
Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Disease Models, Animal; Edema | 2020 |
Optimized Ellagic Acid-Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats.
Topics: Animals; Disease Models, Animal; Ellagic Acid; Indomethacin; Male; Oxidative Stress; Particle Size; | 2020 |
Cytoprotective and antisecretory properties of methanolic extract of
Topics: Animals; Anti-Ulcer Agents; Caesalpinia; Cryoprotective Agents; Disease Models, Animal; Ethanol; Gas | 2020 |
Manjarix attenuated pain and joint swelling in a rat model of monosodium iodoacetate-induced osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis, Experimental; Cartilage, Articular; Collag | 2020 |
Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Humans; Indomethacin; L | 2022 |
In vitro and in vivo anti-inflammatory effects of an ethanol extract from the aerial parts of Eryngium carlinae F. Delaroche (Apiaceae).
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Response Re | 2021 |
Gastroprotective and cicatrizing activity of the Ziziphus joazeiro Mart. leaf hydroalcoholic extract.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Female; Gastric Mucosa; Indomethacin; M | 2020 |
Effect of Beta 3 Adrenoreceptor Modulation on Patency of the Ductus Arteriosus.
Topics: Adrenergic beta-3 Receptor Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Disease P | 2020 |
The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Gastric Mucosa; Indomethacin; Male; Metformin; N | 2021 |
Probiotic lactobacilli as a promising strategy to ameliorate disorders associated with intestinal inflammation induced by a non-steroidal anti-inflammatory drug.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Supplements; Disease | 2021 |
Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Fecal Microb | 2022 |
Obesity-associated up-regulation of lipocalin 2 protects gastric mucosa cells from apoptotic cell death by reducing endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Endoplasmic Retic | 2021 |
Solanum xanthocarpum fruit extract promotes chondrocyte proliferation in vitro and protects cartilage damage in collagenase induced osteoarthritic rats (article reference number: JEP 114028).
Topics: Administration, Oral; Alkaline Phosphatase; Animals; Antioxidants; Body Weight; Cartilage, Articular | 2021 |
Zuojin Pill ameliorates inflammation in indomethacin-induced gastric injury via inhibition of MAPK pathway.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Cytokines; Disease Models, Animal; Drugs, Chinese He | 2021 |
Design, synthesis, and molecular docking of novel 3,5-disubstituted-1,3,4-oxadiazole derivatives as iNOS inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Enzyme Inhibitors; In | 2021 |
Evaluation of the Gastroprotective Effect of the Flavonoid Complex from Lychnis chalcedonica L. on the Models of Experimental Ulcerogenesis.
Topics: Animals; Animals, Outbred Strains; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Ethano | 2021 |
Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing.
Topics: Acanthaceae; Acetic Acid; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Res | 2021 |
Assessment of the Anti-Allodynic and Anti-Hyperalgesic Efficacy of a Glycine Transporter 2 Inhibitor Relative to Pregabalin, Duloxetine and Indomethacin in a Rat Model of Cisplatin-Induced Peripheral Neuropathy.
Topics: Analgesics; Animals; Benzamides; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug | 2021 |
Dimethyl sulfoxide but not indomethacin is efficient for healing in hydrofluoric acid eye burns.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Burns, Chemical; Dimethyl Sulfoxide; | 2017 |
Protective Effect of Pinitol Against Inflammatory Mediators of Rheumatoid Arthritis via Inhibition of Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22).
Topics: Animals; Antioxidants; Arthritis, Rheumatoid; Cytokines; Disease Models, Animal; Indomethacin; Infla | 2017 |
Oxazolo[4,5-b]pyridine-Based Piperazinamides as GSK-3β Inhibitors with Potential for Attenuating Inflammation and Suppression of Pro-Inflammatory Mediators.
Topics: Amides; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Female; Glyco | 2017 |
Elevated prostaglandin E
Topics: Animals; Cells, Cultured; Cyclic AMP; Dinoprostone; Disease Models, Animal; Hematopoietic Stem Cell | 2018 |
Adult Zebrafish (Danio rerio): An Alternative Behavioral Model of Formalin-Induced Nociception.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Disease Mode | 2017 |
Gastroprotective and Antiulcer Effects of Celastrus paniculatus Seed Oil Against Several Gastric Ulcer Models in Rats.
Topics: Animals; Celastrus; Disease Models, Animal; Ethanol; Female; Gastric Acidity Determination; Gastric | 2018 |
Measurement of gut permeability using fluorescent tracer agent technology.
Topics: Animals; Disease Models, Animal; Fluorescent Dyes; Gastrointestinal Tract; Indomethacin; Intestinal | 2017 |
Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Hyperalgesia; Indomethacin; Interl | 2017 |
Lack of TNF-α signaling through p55 makes the mice more susceptible to acute infection but does not alter state of latency and reactivation of HSV-1.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; DNA, Viral; Female; Gene E | 2018 |
Baicalin protects against gastroduodenal ulcers via the modulation of Nrf2 expression: Experimental, biochemical, and histological analyses.
Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Cimetidine; Disease Models, Animal; Dose-Response Rel | 2017 |
Gastroprotective effect and mode of action of methanol extract of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir (Lamiaceae) leaves on experimental gastric ulcer models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Disease Models, A | 2018 |
Chrysophyllum cainito (apple-star): a fruit with gastroprotective activity in experimental ulcer models.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Female; Fruit; Gastric Mucosa; Indometh | 2019 |
Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Cyclooxygenase 1; Cyclooxygenase 2; Dise | 2018 |
Healing and Antisecretory Effects of Aqueous Extract of
Topics: Acanthaceae; Acetic Acid; Animals; Antioxidants; Disease Models, Animal; Gastric Mucosa; Humans; Ind | 2017 |
Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.
Topics: Animals; Cerebrovascular Circulation; Cognition Disorders; Cyclooxygenase Inhibitors; Disease Models | 2017 |
A novel model to study neonatal Escherichia coli sepsis and the effect of treatment on the human immune system using humanized mice.
Topics: Animals; Betamethasone; Bone Marrow; Cytokines; Disease Models, Animal; Escherichia coli; Escherichi | 2018 |
Establishment of a porcine model of indomethacin-induced intestinal injury.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enterocytes; Fatty Acid-Binding Proteins; Gene Ex | 2018 |
Trigeminal ganglion transcriptome analysis in 2 rat models of medication-overuse headache reveals coherent and widespread induction of pronociceptive gene expression patterns.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Disease Models, A | 2018 |
Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, Myelomono | 2018 |
Intestinal injury alters tissue distribution and toxicity of ZnO nanoparticles in mice.
Topics: Administration, Oral; Animals; Copper; Disease Models, Animal; Indomethacin; Inflammatory Bowel Dise | 2018 |
The gastroprotective effect of N-acetylcysteine and genistein in indomethacin-induced gastric injury in rats.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, | 2018 |
LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrage | 2018 |
Ameliorative effects of indomethacin at different concentrations on endothelial insulin resistance through two distinct pathways.
Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug | 2018 |
Indomethacin increases severity of Clostridium difficile infection in mouse model.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Clostridioides difficile; C | 2018 |
Adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons and neuroimmune activation are prevented by exercise and indomethacin.
Topics: Animals; Basal Forebrain; Binge Drinking; Central Nervous System Depressants; Cholinergic Neurons; D | 2018 |
The effect of aerosolized indomethacin on lung inflammation and injury in a rat model of blunt chest trauma
Topics: Acute Lung Injury; Administration, Inhalation; Aerosols; Animals; Anti-Inflammatory Agents, Non-Ster | 2018 |
Failure of Indomethacin and Radiation to Prevent Blast-induced Heterotopic Ossification in a Sprague-Dawley Rat Model.
Topics: Amputation, Traumatic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blast Injuries; Disease Mod | 2019 |
IL-10 produced by macrophages regulates epithelial integrity in the small intestine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Female; Gastrointestinal M | 2019 |
Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Fluvoxa | 2019 |
Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celiac Disease; Diclofenac; Diet, Gluten-Free; Dis | 2019 |
Elemental Diet Regulates Intestinal Permeability and Antibody Production in Indomethacin-Induced Intestinal Injury Rats.
Topics: Animals; Antibody Formation; Crohn Disease; Disease Models, Animal; Food, Formulated; Indomethacin; | 2019 |
Indomethacin plus minocycline coadministration relieves chemotherapy and antiretroviral drug-induced neuropathic pain in a cannabinoid receptors-dependent manner.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Retroviral Agents; Ant | 2019 |
Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice.
Topics: Animals; Antioxidants; Brazil; Catechin; Chromatography, High Pressure Liquid; Disease Models, Anima | 2019 |
Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Deuterium; Disease Models, Animal | 2019 |
Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats.
Topics: Aluminum Hydroxide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygena | 2019 |
Low dose of indomethacin and Hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis.
Topics: Animals; Anti-Inflammatory Agents; Cartilage; Caspase 1; Cell Line; Chondrocytes; Cytokines; Disease | 2019 |
A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats.
Topics: Animals; Antioxidants; Biomarkers; Biopsy; Cytokines; Disease Models, Animal; Esomeprazole; Immunohi | 2019 |
Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aort | 2019 |
Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers.
Topics: Alchemilla; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Disease Models, Animal; | 2019 |
Humanized mice, a new model to study the influence of drug treatment on neonatal sepsis.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Load; Betamethason | 2013 |
Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catechols; Disease Models, Anim | 2013 |
Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice.
Topics: Animals; Aorta, Thoracic; Calcimycin; Disease Models, Animal; Endothelium, Vascular; Hypertension; I | 2013 |
Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumo | 2013 |
Paradoxical surrogate markers of dental injury-induced pain in the mouse.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cold Temperature; Dental Pulp; Diseas | 2013 |
Effects of vitamin D3 derivative--calcitriol on pharmacological reactivity of aortic rings in a rodent PCOS model.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcitriol; Dihydrotestosterone; Disease Models, Animal; Fe | 2013 |
Gastric antisecretory and antiulcer activity of bovine hemoglobin.
Topics: Animals; Anti-Ulcer Agents; Cattle; Cytoprotection; Disease Models, Animal; Dose-Response Relationsh | 2013 |
GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's. PLoS One. 2012; 7(11): e50630.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; Disease Models, Animal; Glucagon-Li | 2013 |
Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.
Topics: Acetates; Animals; Asthma; Bronchial Hyperreactivity; Constriction, Pathologic; Cyclopropanes; Disea | 2013 |
Evidence for inflammation-mediated memory dysfunction in gastropods: putative PLA2 and COX inhibitors abolish long-term memory failure induced by systemic immune challenges.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Conditioning, Psychological; Disease Models, Animal; | 2013 |
Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model.
Topics: Acetates; Animals; Anti-Ulcer Agents; Cyclopropanes; Disease Models, Animal; Famotidine; Gastric Muc | 2013 |
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Carrageenan; Dinoprostone; Disease Models, Animal; Ed | 2013 |
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.
Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Mode | 2013 |
Does chronic stress enhance the risk of diseases?
Topics: Adrenergic alpha-Antagonists; Angina Pectoris; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chr | 2013 |
Influence of decompression sickness on vasomotion of isolated rat vessels.
Topics: Acetylcholine; Animals; Catecholamines; Decompression Sickness; Disease Models, Animal; Diving; Dose | 2014 |
Development of an automated imaging pipeline for the analysis of the zebrafish larval kidney.
Topics: Animals; Automation; Disease Models, Animal; Embryo, Nonmammalian; Gene Knockdown Techniques; Humans | 2013 |
Protective effect of an immune-modulating diet comprising whey peptides and fermented milk products on indomethacin-induced small-bowel disorders in rats.
Topics: Animals; Bacterial Translocation; Dairy Products; Diet; Dinoprostone; Disease Models, Animal; Fermen | 2014 |
Anti-nociceptive and anti-inflammatory activities of Wrightia arborea.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apocynaceae; Disease Models, Animal; Edema; Female; I | 2013 |
Changes of Absorptive and Secretory Transporting System of (1 → 3) β-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2015 |
Study on analgesic and anti-inflammatory properties of Cordia myxa fruit hydro-alcoholic extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cordia; Disease Models | 2013 |
Specific changes of gut commensal microbiota and TLRs during indomethacin-induced acute intestinal inflammation in rats.
Topics: Animals; Bacterial Adhesion; Disease Models, Animal; Indomethacin; Inflammatory Bowel Diseases; Inte | 2014 |
Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cytokines; Dinoprostone; Disease Mo | 2014 |
Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats.
Topics: Alginates; Anemia; Animals; Anti-Ulcer Agents; Atrophy; Bacterial Translocation; Biomarkers; Capilla | 2014 |
The impact of dehydroepiandrosterone on indomethacin-induced gastric lesions in rats.
Topics: Animals; Antioxidants; Catalase; Cytoprotection; Dehydroepiandrosterone; Disease Models, Animal; Gas | 2014 |
Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage.
Topics: Adult; Aged; Animals; Arachidonic Acid; Calcium Signaling; Cell Line; Disease Models, Animal; Electr | 2014 |
[Effects of selective and non-selective cyclooxygenase 2 inhibitors on heterotopic ossification in rat model with Achilles tenotomy].
Topics: Achilles Tendon; Animals; Bone Morphogenetic Protein 2; Celecoxib; Cyclooxygenase 2; Cyclooxygenase | 2014 |
Gliadin intake alters the small intestinal mucosa in indomethacin-treated HLA-DQ8 transgenic mice.
Topics: Animals; Apoptosis; Caspase 3; Celiac Disease; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diseas | 2014 |
Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Gastric Mucosa; Indomethacin; Ma | 2013 |
Difficult establishment of a chronic nonsteroidal anti-inflammatory drugs induced gastric inflammation rat model due to gastric adaptation and small bowel damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Gastric Mucosa; Glucosamin | 2014 |
The effect of indomethacin, myeloperoxidase, and certain steroid hormones on bactericidal activity: an ex vivo and in vivo experimental study.
Topics: Adult; Animal Structures; Animals; Anti-Infective Agents; Blood Bactericidal Activity; Cells, Cultur | 2014 |
Deciphering PDT-induced inflammatory responses using real-time FDG-PET in a mouse tumour model.
Topics: Animals; Biological Transport; Cell Line, Tumor; Disease Models, Animal; Female; Fluorodeoxyglucose | 2014 |
Protective effect of indomethacin in renal ischemia-reperfusion injury in mice.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Cyclooxygenase 1; | 2014 |
Antiulcer activity of the ethanolic extract and ethyl acetate fraction of the leaves of Markhamia tomentosa in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Bignoniaceae; Chromatography, Liquid; Disease Models, Animal; | 2014 |
Testing stem cell therapy in a rat model of inflammatory bowel disease: role of bone marrow stem cells and stem cell factor in mucosal regeneration.
Topics: Animals; Bone Marrow Cells; Disease Models, Animal; Indomethacin; Inflammatory Bowel Diseases; Intes | 2014 |
Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassett | 2014 |
Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Down-Regulation; Hippocampus; Indomethac | 2014 |
Rational Design and Synthesis of Benzamides as Non-ulcerogenic Anti-inflammatory Agents.
Topics: Animals; Benzamides; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Carrageenan; Cyclooxy | 2015 |
Oat1/3 restoration protects against renal damage after ischemic AKI.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Glomerular Filtration Rate; Indomethac | 2015 |
Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats.
Topics: Aloe; Animals; Anti-Inflammatory Agents; Antioxidants; Chemokine CXCL1; Cytoprotection; Disease Mode | 2014 |
Indomethacin preconditioning induces ischemic tolerance by modifying zinc availability in the brain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Carrier Proteins; Cell Death; Chelating Age | 2015 |
Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness.
Topics: Animals; Cerebral Arteries; Disease Models, Animal; Elastin; Endothelium, Vascular; Enzyme Inhibitor | 2015 |
Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclosporine; Cytoprote | 2015 |
Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents; Antipyretics; Corchorus; Disease Models, Animal; Dose-Response Re | 2015 |
Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmunity; Cellular Microenvironment; Disease M | 2015 |
Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Copper; Disease Models, A | 2015 |
Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats.
Topics: Animals; Anti-Ulcer Agents; Carica; Disease Models, Animal; Dose-Response Relationship, Drug; Duoden | 2015 |
Perioperative alendronate, risedronate, calcitonin and indomethacin treatment alters femoral stem fixation and periprosthetic bone mineral density in ovariectomized rats.
Topics: Absorptiometry, Photon; Alendronate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, | 2015 |
Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata.
Topics: Anacardiaceae; Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Dose-Response Rel | 2016 |
Toll-like receptor (TLR) 2 agonists ameliorate indomethacin-induced murine ileitis by suppressing the TLR4 signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Migration Assays, Leukocyte; Cell Movement; C | 2015 |
Boswellia carterii liquisolid systems with promoted anti-inflammatory activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Boswellia; Carrageenan; Cellulose; Chemistr | 2015 |
Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line, Tumor; Cells, Cul | 2015 |
Locally Delivered Nonsteroidal Antiinflammatory Drug: A Potential Option for Heterotopic Ossification Prevention.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Prolife | 2015 |
Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
Topics: Animals; Animals, Newborn; Antidiarrheals; Arthritis; Capsaicin; Cytokines; Disease Models, Animal; | 2015 |
Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity.
Topics: Animals; Bignoniaceae; Cell Survival; Cells, Cultured; Chitosan; Disease Models, Animal; Drug Carrie | 2015 |
Evaluation of urine fibrinogen level in a murine model of contrast-induced nephropathy.
Topics: Acute Kidney Injury; Animals; Biomarkers; Creatinine; Disease Models, Animal; Early Diagnosis; Fibri | 2016 |
Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury.
Topics: Animals; Antineoplastic Agents; Calcium; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Mo | 2015 |
Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Cyc | 2015 |
The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Gastric Mucosa; Gastrointestinal Agents; Hist | 2016 |
Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 1; Cells, Cultured; Disease Models, Animal | 2016 |
New Coumarin Derivatives as Potent Selective COX-2 Inhibitors: Synthesis, Anti-Inflammatory, QSAR, and Molecular Modeling Studies.
Topics: Animals; Carrageenan; Coumarins; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Di | 2015 |
Gastroprotective and Antioxidant Effects of Lobaria pulmonaria and Its Metabolite Rhizonyl Alcohol on Indomethacin-Induced Gastric Ulcer.
Topics: Alcohols; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationsh | 2015 |
Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model.
Topics: Animals; Apoptosis; Colon; Disease Models, Animal; Enterocolitis; Female; Gastrointestinal Agents; I | 2015 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
Emu oil offers protection in Crohn's disease model in rats.
Topics: Aloe; Animals; Antioxidants; Cecum; Crohn Disease; Disease Models, Animal; Female; Ileum; Indomethac | 2016 |
The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model.
Topics: Acetic Acid; Administration, Topical; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese He | 2016 |
A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimen | 2016 |
Naringenin reduces inflammatory pain in mice.
Topics: Analgesics; Animals; Cytokines; Dipyrone; Disease Models, Animal; Dose-Response Relationship, Drug; | 2016 |
Inflammatory Bowel Disease.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Disease Models, Animal; Drug Discovery; Female; Gastr | 2016 |
Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Disease Models, Animal; D | 2016 |
Indomethacin injury to the rat small intestine is dependent upon biliary secretion and is associated with overgrowth of enterococci.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Translocation; Bile; Bile Ducts; Disease | 2016 |
[Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation--Study of Therapeutic Equivalence].
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal | 2016 |
Psychological stress exacerbates NSAID-induced small bowel injury by inducing changes in intestinal microbiota and permeability via glucocorticoid receptor signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Gastrointestinal Microbiom | 2017 |
The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose | 2016 |
Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Anticonvulsants; Cyclooxygenase Inhibitors; Disease Mode | 2016 |
Assessment of the effects of oseltamivir and indomethacin on dopamine, 5-HIAA, and some oxidative stress markers in stomach and brain of Salmonella typhimurium-infected rats.
Topics: Animals; Brain; Disease Models, Animal; Dopamine; Female; Hydrogen Peroxide; Hydroxyindoleacetic Aci | 2016 |
Interleukin-1β and interleukin-6 enhance thermal prolongation of the LCR in decerebrate piglets.
Topics: Animals; Animals, Newborn; Body Temperature; Cyclooxygenase Inhibitors; Decerebrate State; Disease M | 2016 |
Effects of Mesalazine on Morphological and Functional Changes in the Indomethacin-Induced Inflammatory Bowel Disease (Rat Model of Crohn's Disease).
Topics: Animals; Crohn Disease; Disease Models, Animal; Glucuronates; Indomethacin; Inflammation; Inflammato | 2017 |
Anti-ulcer mechanisms of polyphenols extract of Euphorbia umbellata (Pax) Bruyns (Euphorbiaceae).
Topics: Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Chromatography, Hig | 2016 |
Tissue-selective inflammation in the oral cavity of the rat.
Topics: Animals; Carrageenan; Cheek; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Histam | 2016 |
Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats.
Topics: Animals; Crohn Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Comb | 2016 |
Influence of Adrenalectomy on Protective Effects of Urocortin I, a Corticotropin-Releasing Factor, Against Indomethacin-Induced Enteropathy in Rats.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Respon | 2016 |
Development of microparticles for oral administration of the non-conventional radical scavenger IAC and testing in an inflammatory rat model.
Topics: Acetaminophen; Administration, Oral; Animals; Disease Models, Animal; Free Radical Scavengers; Glyce | 2016 |
Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cotton Fiber; | 2016 |
Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice.
Topics: Alginates; Animals; Disease Models, Animal; Gastrointestinal Motility; Glucuronic Acid; Hexuronic Ac | 2016 |
Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytochrome P-450 CYP3A; Disease Models, Animal; Do | 2016 |
Uterus-targeted liposomes for preterm labor management: studies in pregnant mice.
Topics: Animals; Disease Models, Animal; Drug Compounding; Female; Gene Expression; Hormone Antagonists; Hum | 2016 |
In vivo effects of s-pantoprazole, polaprenzinc, and probiotic blend on chronic small intestinal injury induced by indomethacin.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2016 |
Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
Topics: Animals; Antioxidants; Capsaicin; Chromatography, High Pressure Liquid; Chronic Disease; Disease Mod | 2017 |
Isolation, characterization, and in silico, in vitro and in vivo antiulcer studies of isoimperatorin crystallized from Ostericum koreanum.
Topics: Animals; Anti-Ulcer Agents; Apiaceae; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Cell | 2017 |
Gastroprotective activity of the resin from Virola oleifera.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Chromatography, Thin Layer; Disease Models | 2017 |
The influence of seasonality on the content of goyazensolide and on anti-inflammatory and anti-hyperuricemic effects of the ethanolic extract of Lychnophora passerina (Brazilian arnica).
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Brazil; Bridged-Ring Compounds; Chromatography, High | 2017 |
Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model.
Topics: Analgesia; Animals; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Pr | 2016 |
N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; A | 2017 |
Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats.
Topics: Aluminum Hydroxide; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Models, Animal; Dose- | 2017 |
Efficacy of oral supplemental hydration for the prevention of contrast-induced nephropathy in rats.
Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Fluid Therapy; Indomethacin; I | 2017 |
Indomethacin counteracts the effects of chronic social defeat stress on emotional but not recognition memory in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Avoidance Learning; Behavior, Animal; Chronic Dise | 2017 |
Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Disease Models | 2017 |
The effect of indomethacin on systemic and renal hemodynamics in neonatal piglets during experimental endotoxemia.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Blood Press | 2008 |
Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst.
Topics: Animals; Anti-Inflammatory Agents; Bacopa; Cyclooxygenase 2; Disease Models, Animal; Dose-Response R | 2008 |
Enzyme-modified cheese exerts inhibitory effects on allergen permeation in rats suffering from indomethacin-induced intestinal inflammation.
Topics: Allergens; Amino Acid Sequence; Animals; Caco-2 Cells; Caseins; Cell Membrane Permeability; Cheese; | 2008 |
Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed.
Topics: 4-Aminopyridine; Acetylcholine; Administration, Oral; Animals; Aorta; Blood Glucose; Blood Pressure; | 2008 |
A surgical ankle sprain pain model in the rat: effects of morphine and indomethacin.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Ankle Injuries; Anti-Inflammatory Agents, Non-Ste | 2008 |
BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis.
Topics: Animals; Ankle Joint; Arthritis, Experimental; Cell Proliferation; Collagen Type II; Disease Models, | 2008 |
The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.
Topics: Animals; Bone and Bones; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indomethacin; Injectio | 2009 |
Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Disease Mod | 2008 |
Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, | 2008 |
Topical anti-inflammatory and antipruritic effects of Alpinia katsumadai extracts.
Topics: Administration, Topical; Alpinia; Animals; Anti-Inflammatory Agents; Antipruritics; Disease Models, | 2009 |
Preconditioning with acute and chronic lithium administration reduces ischemia/reperfusion injury mediated by cyclooxygenase not nitric oxide synthase pathway in isolated rat heart.
Topics: Animals; Cardiotonic Agents; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relati | 2008 |
Paracrine effects of endothelial cells in a diabetic mouse model: capacitative calcium entry stimulated thromboxane release.
Topics: Animals; Aorta; Calcium Signaling; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothel | 2008 |
Anti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animals.
Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relatio | 2008 |
Effects of nitrosative stress and reactive oxygen-scavenging systems in esophageal physiopathy under streptozotocin-induced experimental hyperglycemia.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Esophagus; Glutathione P | 2008 |
Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice.
Topics: Acetylcholine; Animals; Antigens; Asthma; Atropine; Bronchial Hyperreactivity; Bronchodilator Agents | 2008 |
Role of nitric oxide synthase and cyclooxygenase in hyperdynamic splanchnic circulation of portal hypertension.
Topics: Animals; Aorta, Abdominal; Cyclooxygenase Inhibitors; Disease Models, Animal; Epoprostenol; Hyperten | 2008 |
Impaired mitochondria-dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance.
Topics: Animals; Cerebral Arteries; Cyclooxygenase Inhibitors; Diazoxide; Disease Models, Animal; Dose-Respo | 2009 |
Anti-inflammatory and anti-pyretic activities of earthworm extract-Lampito mauritii (Kinberg).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Disease Models, Animal; | 2009 |
Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow.
Topics: Acetylcholine; Adaptation, Physiological; Animals; Antioxidants; Caveolin 1; Cyclic N-Oxides; Diabet | 2009 |
T-type channel blocking properties and antiabsence activity of two imidazo[1,2-b]pyridazine derivatives structurally related to indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Calcium Channel Blockers; Calcium | 2009 |
Prostaglandin mediates endotoxaemia-induced hypophagia by activation of pro-opiomelanocortin and corticotrophin-releasing factor neurons in rats.
Topics: Adrenocorticotropic Hormone; alpha-MSH; Animals; Anorexia; Appetite Regulation; Corticosterone; Cort | 2009 |
Preventive effect of co-administration of water containing magnesium ion on indomethacin induced lesions of gastric mucosa in adjuvant-induced arthritis rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disease Models, Animal; D | 2009 |
KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction.
Topics: Animals; Callithrix; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Female; Gene E | 2009 |
Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen Type II; Disease Models, Animal | 2009 |
Antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds.
Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Anti-Inflammatory Agents; Anti-Ulcer Age | 2009 |
Inhibition of monosodium urate crystal-induced inflammation by withaferin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Ergosterol; | 2008 |
Differential involvement of COX1 and COX2 in the vasculopathy associated with the alpha-galactosidase A-knockout mouse.
Topics: Acetylcholine; alpha-Galactosidase; Animals; Aorta, Thoracic; Arachidonic Acid; Cyclooxygenase 1; Cy | 2009 |
Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats.
Topics: Alveolar Bone Loss; Animals; Arachidonic Acid; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, | 2009 |
Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-R | 2009 |
Preclinical pharmacokinetic and pharmacodynamic evaluation of thiazolidinone PG15: an anti-inflammatory candidate.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cycloox | 2009 |
Anti-ulcer activity of IAC, a novel free-radical scavenger, in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxida | 2009 |
Delayed neonatal closure of the ductus arteriosus following early in utero exposure to indomethacin in the rat.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibito | 2009 |
Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Caspase 3; Dinopr | 2009 |
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Bl | 2009 |
Fetal reversed constrictive effect of indomethacin and postnatal delayed closure of the ductus arteriosus following administration of transplacental magnesium sulfate in rats.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Ant | 2009 |
Anti-inflammatory properties of cryptolepine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Cyclooxygenase inhibitors repress vascular hyaluronan-synthesis in murine atherosclerosis and neointimal thickening.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Carotid Arteries; Cyclooxygenase Inhibitors; Disease Mo | 2009 |
[Ulcer genesis and endogenous intoxication].
Topics: Animals; Disease Models, Animal; Endotoxemia; Gastric Mucosa; Indomethacin; Lipid Metabolism; Lipids | 2008 |
Role of alpha-2 adrenergic receptors in anti-ulcer effect mechanism of estrogen and luteinising hormone on rats.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Anim | 2009 |
Gastric antisecretory and antiulcer activities of Cyclea peltata (Lam.) Hook. f. & Thoms. in rats.
Topics: Animals; Anti-Ulcer Agents; Catalase; Cyclea; Disease Models, Animal; Ethanol; Gastric Juice; Gastri | 2009 |
Lipopolysaccharide from Escherichia coli prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence.
Topics: Animals; Cell Adhesion; Disease Models, Animal; Endothelium; Escherichia coli; Gastric Mucosa; Indom | 2009 |
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Coloni | 2009 |
Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Dose-Re | 2009 |
Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action.
Topics: Animals; Antioxidants; Cyclohexane Monoterpenes; Disease Models, Animal; Dose-Response Relationship, | 2009 |
Effect of a gastrin-releasing peptide receptor antagonist and a proton pump inhibitor association in an animal model of gastritis.
Topics: Animals; Bombesin; Disease Models, Animal; Gastric Mucosa; Gastritis; Indomethacin; Lipid Peroxidati | 2009 |
PACAP and VIP differentially preserve neurovascular reactivity after global cerebral ischemia in newborn pigs.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Arterioles; Brain Ischemia; Cere | 2009 |
Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, D | 2009 |
Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid.
Topics: Animals; Cell Line; Disease Models, Animal; Humans; I-kappa B Proteins; Indomethacin; Intestinal Dis | 2009 |
Protective Effect of Origanum majorana L. 'Marjoram' on various models of gastric mucosal injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Drugs, Chine | 2009 |
Ccl2 and Ccl3 mediate neutrophil recruitment via induction of protein synthesis and generation of lipid mediators.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Benzoquinones; Cells, Cultured; Chemokine C | 2009 |
Gastroprotection of (-)-alpha-bisabolol on acute gastric mucosal lesions in mice: the possible involved pharmacological mechanisms.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gastr | 2010 |
Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats.
Topics: Acetylcholine; Age Factors; Aging; Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Hetero | 2009 |
Relative inhibitory activity of bile acids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, and chenodeoxycholic acid inhibition of tumour promotion in mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Bile A | 2009 |
Cellular stress-response modulators in the acute rat model of peritoneal dialysis.
Topics: Animals; Dialysis Solutions; Disease Models, Animal; Epithelium; HSP72 Heat-Shock Proteins; Image Pr | 2010 |
Urocortin prevents indomethacin-induced small intestinal lesions in rats through activation of CRF2 receptors.
Topics: Aniline Compounds; Animals; Bacterial Translocation; Corticotropin-Releasing Hormone; Cytoprotection | 2010 |
Modulation of inflammatory response by selective inhibition of cyclooxygenase-1 and cyclooxygenase-2 in acute kidney injury.
Topics: Acute Kidney Injury; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokin | 2010 |
Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Cyclooxygenase Inhi | 2010 |
Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis.
Topics: Acetylcholine; Animals; Aorta; Atorvastatin; Biological Factors; Blood Cell Count; Blood Pressure; C | 2009 |
The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Caffeine; Central Nervous Syste | 2009 |
Antioxidant effects of mycophenolate mofetil in a murine pleurisy model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Catalase; Cell Count; Cell Movement; | 2009 |
Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Cholester | 2009 |
In vivo dilatation of the ductus arteriosus induced by furosemide in the rat.
Topics: Animals; Animals, Newborn; Cesarean Section; Cyclooxygenase Inhibitors; Dilatation, Pathologic; Dise | 2010 |
Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Chronic Disease; Diclof | 2010 |
Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Agar Gel; Enzyme Inhibitors; Finaster | 2010 |
Behavioral and urological evaluation of a testicular pain model.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Indomethacin; Male; Nerve | 2010 |
EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose | 2009 |
Anti-inflammatory and antipyretic effects of Sonchus oleraceus in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cotton Fiber; Disease Models, Animal; Edema; Fever; | 2010 |
Gastroprotective activity of Trichosanthes cucumerina in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Ethanol; Female; Gastric Juice; Gast | 2010 |
Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Disease Models, Animal; Duodena | 2010 |
Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.
Topics: Acetylcysteine; Animals; Anti-Ulcer Agents; Antioxidants; Capsaicin; Disease Models, Animal; Diterpe | 2010 |
Cyclooxygenase-2 preserves flow-mediated remodelling in old obese Zucker rat mesenteric arteries.
Topics: Acetylcholine; Age Factors; Animals; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Di | 2010 |
Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice.
Topics: Animals; Cardiovascular Agents; Cells, Cultured; Dinoprostone; Disease Models, Animal; Ductus Arteri | 2010 |
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Indomethacin | 2010 |
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr | 2010 |
Neuroprotective effects vary across nonsteroidal antiinflammatory drugs in a mouse model of developing excitotoxic brain injury.
Topics: Acetaminophen; Adrenal Cortex Hormones; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Ste | 2010 |
Antiulcerogenic activity of ethanolic leaf extract of Lasianthera africana.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Indomethacin; Magnoliopsida; Phytotherapy; Plant | 2009 |
Probiotic bacteria Escherichia coli strain Nissle 1917 attenuates acute gastric lesions induced by stress.
Topics: Animals; Capsaicin; Cyclooxygenase 2; Disease Models, Animal; Escherichia coli; Gastric Mucosa; Ghre | 2009 |
Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Cytochrome P-450 CYP1A1; Dextran Sulfate; Dinoprostone | 2010 |
Differences between orofacial inflammation and cancer pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Carcinoma 256, Wa | 2010 |
Acemetacin antinociceptive mechanism is not related to NO or K+ channel pathways.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Indo | 2010 |
Fetal pulmonary vascular remodeling in a rat model induced by hypoxia and indomethacin.
Topics: Actins; Animals; Animals, Newborn; Blotting, Western; Cardiovascular Agents; Disease Models, Animal; | 2011 |
Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2010 |
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Rele | 2010 |
Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats.
Topics: Aging; Animals; Behavior, Animal; Brain; Disease Models, Animal; Indomethacin; Male; Memory Disorder | 2010 |
A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Gouty; Benzodi | 2011 |
Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models.
Topics: Achyrocline; Animals; Anti-Ulcer Agents; Brazil; Cimetidine; Cytoprotection; Disease Models, Animal; | 2010 |
Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.
Topics: Adenine; Amylases; Animals; Calcium; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cycloox | 2010 |
Evaluation of anti-leishmanial activity by induction of nitric oxide and inhibition of prostaglandin in Balb/c mice infected with Leishmania major.
Topics: Analysis of Variance; Animals; Arginine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; | 2009 |
Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Famotidine; Histamine H2 Antagonists | 2010 |
Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease M | 2010 |
In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Gastric Mucosa; Hydrogen-I | 2010 |
Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension.
Topics: Administration, Inhalation; Aerosols; Animals; Animals, Newborn; Antihypertensive Agents; Blood Pres | 2010 |
The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo.
Topics: Analgesics; Anemarrhena; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability | 2010 |
Anti-inflammatory and analgesic effects displayed by peptides derived from PKI55 protein, an endogenous protein kinase C inhibitor.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Dose-Response | 2010 |
Anti-inflammatory activity of Trichosanthes cucumerina Linn. in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Response Relationship, | 2010 |
Pravastatin administration does not induce detrimental effects on hemodynamics and collaterals of portal hypertensive rats.
Topics: Animals; Collateral Circulation; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Re | 2010 |
Indomethacin activates peroxisome proliferator-activated receptor γ to improve insulin resistance in cotton pellet granuloma model.
Topics: Adipose Tissue; Animals; Cell Movement; Cotton Fiber; Cyclooxygenase 2; Dinoprostone; Disease Models | 2010 |
Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Drugs, Chinese Herbal; Ethanol; Ga | 2010 |
Indomethacin reduces cell damage: shedding new light on compartment syndrome.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Compartment Syndromes; Disease Models, | 2010 |
Comparison of prostaglandin E2 receptor subtype 4 agonist and sulfasalazine in mouse colitis prevention and treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cell Proliferation; Colitis; Colon; D | 2010 |
Lactobacillus casei reduces the inflammatory joint damage associated with collagen-induced arthritis (CIA) by reducing the pro-inflammatory cytokines: Lactobacillus casei: COX-2 inhibitor.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Cyclooxygenase 2 Inhibitors; Cytokines; Dise | 2011 |
In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Brazil; Disease Models, Animal; Edema; Electropho | 2011 |
Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2011 |
A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches.
Topics: Animals; Calcitonin Gene-Related Peptide; Cerebral Arteries; Cyclooxygenase Inhibitors; Disease Mode | 2010 |
Anti-inflammatory activity of Penstemon gentianoides and Penstemon campanulatus.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Edema; Flavonoids; Indometh | 2011 |
Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Synergi | 2012 |
The effects of methylprednisolone, montelukast and indomethacine in experimental otitis media with effusion.
Topics: Acetates; Administration, Oral; Animals; Biopsy, Needle; Cyclopropanes; Disease Models, Animal; Dose | 2011 |
[The influence of indomethacin on TNFα and skeletal muscle protein catabolism in chronic obstructive pulmonary disease rat model].
Topics: Animals; Disease Models, Animal; Indomethacin; Male; Muscle, Skeletal; Pulmonary Disease, Chronic Ob | 2010 |
Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Disease Models, Animal; Dos | 2010 |
Reduced small-intestinal injury induced by indomethacin in interleukin-17A-deficient mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CCL2; Chemokine CXCL1; Disease Models, A | 2011 |
Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models.
Topics: Animals; Anti-Ulcer Agents; Chromatography, High Pressure Liquid; Disease Models, Animal; Ethanol; F | 2011 |
Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.
Topics: Animals; Antipsychotic Agents; Capillary Permeability; Dinoprostone; Disease Models, Animal; Dopamin | 2011 |
Cyclooxygenase inhibition up-regulates liver carnitine palmitoyltransferase 1A expression and improves fatty liver.
Topics: Animals; Carnitine O-Palmitoyltransferase; Cyclooxygenase Inhibitors; Disease Models, Animal; Fatty | 2011 |
Morphometric analysis of the porcine gastrointestinal tract in a 10-day high-dose indomethacin administration with or without probiotic bacteria Escherichia coli Nissle 1917.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship | 2011 |
Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Coix; Disease Models, Animal; Humans; Indomethacin; M | 2011 |
Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bromeliaceae; Disease Models, A | 2010 |
Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, | 2010 |
Curative effect of selenium against indomethacin-induced gastric ulcers in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Disease Models, An | 2011 |
Apple peel polyphenols protect against gastrointestinal mucosa alterations induced by indomethacin in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chlorogenic Acid; Disease Models, Animal; Flavonoid | 2011 |
Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer A | 2011 |
Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Catechin; Disease | 2011 |
The effect of montelukast in a model of gouty arthritis induced by sodium monourate crystals.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Cell Migration Assays, | 2011 |
Protective effect of aqueous extract of Bombax malabaricum DC on experimental models of inflammatory bowel disease in rats and mice.
Topics: Acetic Acid; Animals; Bombax; Colitis; Disease Models, Animal; Female; India; Indomethacin; Inflamma | 2011 |
Intracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyt | 2011 |
Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Carrageenan; Cell Line, Tum | 2012 |
Exploration of target molecules for molecular imaging of inflammatory bowel disease.
Topics: Animals; Biomarkers; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Fluorodeoxyg | 2011 |
The effects of NSAIDs on types I, II, and III collagen metabolism in a rat osteoarthritis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Celecoxib; Chondrocytes; Col | 2012 |
Microencapsulation enhances the anti-ulcerogenic properties of Entada africana leaf extract.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Capsules; Chemistry, Pharmaceutical; Cytoprotectio | 2011 |
Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models.
Topics: Animals; Anti-Ulcer Agents; Catalase; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Eth | 2011 |
Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae).
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gas C | 2011 |
Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Ferment | 2010 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; F | 2011 |
Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae).
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Diterpenes; Ethanol; Gastric Acid; Hydrogen-Ion | 2011 |
Effects of milnacipran, duloxetine and indomethacin, in polyarthritic rats using the Randall-Selitto model.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimen | 2011 |
Effects of pioglitazone and rosiglitazone on vascular function of mesenteric resistance arteries in rat genetic hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Blood Pr | 2011 |
Further evidence of the antiulcer activity of IAC, a novel free radical scavenger.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Free Ra | 2011 |
Models of inflammation: measuring gastrointestinal ulceration in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Female; Indomethacin; Infl | 2001 |
Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region.
Topics: Adrenergic beta-3 Receptor Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Body Tem | 2011 |
The anti-inflammatory activity of dillapiole and some semisynthetic analogues.
Topics: Allyl Compounds; Animals; Anti-Inflammatory Agents; Carrageenan; Chromatography; Dioxoles; Disease M | 2011 |
Reduction of post-surgical pericardial adhesions using a pig model.
Topics: Animals; Biological Availability; Biomarkers; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Mod | 2012 |
Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.
Topics: Acetylcholine; Animals; Blood Pressure; Body Weight; Disease Models, Animal; Dyslipidemias; Epoprost | 2012 |
Therapeutic effect of Withania somnifera on pristane-induced model of SLE.
Topics: Animals; Antigen-Antibody Complex; Autoantibodies; Cytokines; Disease Models, Animal; Female; Indome | 2012 |
[Gastric mucosal susceptibility for ulcerogenic effect of indometacin at different time points of streptozotocin-induced diabetes development].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Corticosterone; Diabetes Mellitus, | 2011 |
Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Boswellia; Carrageenan; Chromatography, Liquid; Commi | 2012 |
Anti-inflammatory potential of thienopyridines as possible alternative to NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Line; Cytokines; Dis | 2012 |
Essential oil of Croton zehntneri and its major constituent anethole display gastroprotective effect by increasing the surface mucous layer.
Topics: Administration, Oral; Allylbenzene Derivatives; Animals; Anisoles; Brazil; Croton; Disease Models, A | 2013 |
Indomethacin uptake into poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5]-undecane) network: In vitro and in vivo controlled release study.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Chemistry, Pharmaceutical; | 2012 |
Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Cimetidine; Cytoprotection | 2011 |
Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs.
Topics: Amines; Analgesics; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2012 |
Protective effects of acute lithium preconditioning against renal ischemia/reperfusion injury in rat: role of nitric oxide and cyclooxygenase systems.
Topics: Animals; Antimanic Agents; Disease Models, Animal; Indomethacin; Ischemic Preconditioning; Kidney; L | 2012 |
Antiulcer principle from Zingiber montanum.
Topics: Animals; Anti-Ulcer Agents; Chromatography; Cytoprotection; Disease Models, Animal; Dose-Response Re | 2012 |
Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CXCL1; Cytokines; | 2012 |
Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy.
Topics: Acetophenones; Acetylcysteine; Animals; Animals, Genetically Modified; Antioxidants; Behavior, Anima | 2012 |
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experiment | 2012 |
Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb.
Topics: Animals; Anti-Ulcer Agents; Calophyllum; Catalase; Chemical Fractionation; Chromatography, High Pres | 2012 |
Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Cyclooxygenase 2; Disease Models | 2012 |
Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Disease Models, Animal; Electro | 2012 |
Influence of experimental periodontitis on cholinergic stimulation of K⁺ release in rat parotid glands.
Topics: Animals; Carbachol; Cell Membrane; Cholinergic Agonists; Cyclooxygenase Inhibitors; Disease Models, | 2012 |
Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration.
Topics: Animals; Anti-Inflammatory Agents; Bethanechol; Disease Models, Animal; Guanidines; Histamine Agonis | 2012 |
[Gastroprotective activity of modified glutamyl-tryptophan dipeptide analogs and melatonin].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cytoprotection; D | 2012 |
Nuclear factor kappa B: a pro-inflammatory, transcription factor-mediated signalling pathway in lung carcinogenesis and its inhibition by nonsteroidal anti-inflammatory drugs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell | 2012 |
Protease-activated receptor-stimulated interleukin-6 expression in endometriosis-like lesions in an experimental mouse model of endometriosis.
Topics: Animals; Apoptosis; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Endomet | 2012 |
Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte.
Topics: Animals; Apoptosis; Cartilage, Articular; Celecoxib; Chondrocytes; Collagen Type II; Cyclooxygenase | 2012 |
Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice.
Topics: Acrolein; Animals; Anti-Ulcer Agents; Aspirin; Cinnamomum zeylanicum; Disease Models, Animal; Drugs, | 2013 |
Antiulcerogenic effect of Croton urucurana Baillon bark.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Croton; Disease Models, Animal; Ethanol; Female; Gastric Ac | 2012 |
Mesenteric arteries responsiveness to acute variations of wall shear stress is impaired in rats with liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; | 2012 |
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.
Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine | 2012 |
Upregulation of intrinsic apoptotic pathway in NSAIDs mediated chemoprevention of experimental lung carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cyclo | 2012 |
Anti-inflammatory and analgesic properties of the ethanolic extract of Cnidoscolus aconitifolius in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2011 |
Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyc | 2013 |
Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf.
Topics: Animals; Anti-Ulcer Agents; Bauhinia; Chloroform; Chromatography, High Pressure Liquid; Cytoprotecti | 2012 |
Terminal-restriction fragment length polymorphism (T-RFLP) analysis for changes in the gut microbiota profiles of indomethacin- and rebamipide-treated mice.
Topics: Alanine; Animals; Cecum; Disease Models, Animal; DNA, Bacterial; Drug Therapy, Combination; Female; | 2012 |
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic | 2012 |
Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer's disease models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease | 2012 |
Polyphenolic profile and biological activity of Salvia splendens leaves.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Diabetes Mellitus, Experimental; Dis | 2012 |
Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cytoprotection; Dinoprostone; Disease Models, Anim | 2012 |
Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats.
Topics: Acetaminophen; Adenine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antioxidants; Disea | 2012 |
[A comparative analysis of corticosterone, cortisol and dexametasone effects on gastric erosion in rats].
Topics: Animals; Blood Glucose; Corticosterone; Dexamethasone; Disease Models, Animal; Hydrocortisone; Indom | 2012 |
Effects of statins in an indomethacin-induced gastric injury model in rats.
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ind | 2012 |
The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Central Nervous S | 2013 |
GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model.
Topics: Animals; Crohn Disease; Disease Models, Animal; Female; Glucagon-Like Peptide 2; Humans; Indomethaci | 2012 |
Hemin ameliorates indomethacin-induced small intestinal injury in mice through the induction of heme oxygenase-1.
Topics: Animals; Blotting, Western; Chemokines; Cytokines; Disease Models, Animal; DNA Primers; Enteritis; E | 2013 |
Suppression of type II collagen-induced arthritis by ICM0301B, a new angiogenesis inhibitor.
Topics: Angiogenesis Inhibitors; Animals; Arthritis; Collagen Type II; Disease Models, Animal; Epoxy Compoun | 2013 |
Analgesic and anti-inflammatory activity of podophyllotoxin derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carbazoles; Cell Line, Tumor; | 2013 |
Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis.
Topics: Age Factors; Amyloidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Brai | 2002 |
Alterations of intestinal motor responsiveness in a model of mild mesenteric ischemia/reperfusion in rats.
Topics: Acetylcholine; Animals; Chymotrypsin; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2002 |
The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats.
Topics: Acetone; Administration, Oral; Animals; Anti-Ulcer Agents; Disease Models, Animal; Fabaceae; Gastric | 2002 |
Anti-inflammatory sesquiterpene lactones from Lourteigia ballotaefolia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Croton Oil; Disease Models, Animal; In | 2002 |
A novel human fibroblast growth factor treats experimental intestinal inflammation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Ce | 2002 |
The effect of cyclooxygenase-2 inhibitors on spinal fusion.
Topics: Administration, Oral; Animals; Biopsy, Needle; Celecoxib; Confidence Intervals; Cyclooxygenase Inhib | 2002 |
Gastroprotective effects of 'Amla' Emblica officinalis on in vivo test models in rats.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Female; Fruit; Gastric Mucosa; Indometh | 2002 |
Pretreatment with indomethacin protects from acute renal failure following ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Indom | 2002 |
Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat.
Topics: Animals; Anti-Ulcer Agents; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Dru | 2002 |
Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Cyclooxygenase In | 2003 |
[Comparison of the effects of NG-monomethyl-L-arginine and indomethacin on tuberculous arthritis: an experimental study in rats].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Reactive; Disease | 2002 |
[Neuroprotection by aspirin in cerebrovascular pathology].
Topics: Adenosine Triphosphate; Algorithms; Amino Acid Transport System X-AG; Animals; Aspirin; Brain Ischem | 2002 |
The adverse renal effects of prostaglandin-synthesis inhibitors in the newborn rabbit.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Cycloox | 2002 |
A spinal mechanism for the peripheral anti-inflammatory action of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Disease Models, Animal; | 2003 |
Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non- | 2003 |
Mechanisms of transforming growth factor-alpha (TGF-alpha) induced gastroprotection against ethanol in the rat: roles of sensory neurons, sensory neuropeptides, and prostaglandins.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; E | 2003 |
Inhibition of cyclooxygenases reduces complement-induced glomerular epithelial cell injury and proteinuria in passive Heymann nephritis.
Topics: Actins; Animals; Complement System Proteins; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In | 2003 |
[The renal protective effect of selective cyclooxygenase-2 inhibitor on obstructive nephropathy].
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, A | 2002 |
Comparison of two PBR ligands with classical antiinflammatory drugs in LPS-induced arthritis in rats.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Benzodiazepinones; Carrageenan; Dexamethas | 2003 |
Acetic acid-derived prostaglandin-dependent colonic adaptive cytoprotection is preserved in chronic colitis: role of cyclo-oxygenase.
Topics: Acetic Acid; Animals; Colitis; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Rela | 2003 |
Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Carr | 2003 |
Effect of vigabatrin on contractile response to arachidonic acid and prostaglandins in smooth muscle preparations and platelet aggregation in experimental laboratory animals.
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Arachidonic A | 2003 |
Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin.
Topics: Animals; Anti-Ulcer Agents; Cells, Cultured; Chemistry, Pharmaceutical; Cimetidine; Cyclodextrins; D | 2003 |
FGF-20: FGFs--they keep growing and growing and growing!
Topics: Animals; Colitis, Ulcerative; Crohn Disease; Dinoprostone; Disease Models, Animal; Epithelial Cells; | 2003 |
Antinociceptive effects of Teucrium polium L total extract and essential oil in mouse writhing test.
Topics: Analgesics; Analysis of Variance; Animals; Disease Models, Animal; Indomethacin; Male; Mice; Mice, I | 2003 |
Effect of N-acetylcysteine on microcirculation of mucosa in rat ileum in a model of intestinal inflammation.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Free Radical Scavengers; Indomethacin; Inflammation | 2003 |
Mediation of vascular relaxation in epineurial arterioles of the sciatic nerve: effect of diabetes in type 1 and type 2 diabetic rat models.
Topics: Acetylcholine; Animals; Arterioles; Biological Factors; Diabetes Mellitus, Experimental; Diabetes Me | 2003 |
Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; D | 2003 |
Applicability of the Ussing chamber technique to permeability determinations in functionally distinct regions of the gastrointestinal tract in the rat.
Topics: Animals; Colon; Diffusion Chambers, Culture; Disease Models, Animal; Gastric Mucosa; In Vitro Techni | 2003 |
Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2003 |
[Effect of mast cell activation on microcirculation of intestinal mucosa in inflamed small intestine of the rat].
Topics: Animals; Blood Flow Velocity; Crohn Disease; Disease Models, Animal; Histamine H1 Antagonists; Hista | 1998 |
Effect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage.
Topics: Acute Kidney Injury; Animals; Benzamides; Contrast Media; Disease Models, Animal; Disease Progressio | 2003 |
Indomethacin and celecoxib improve tendon healing in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Sectional S | 2003 |
Cedrelopsis grevei induced hypotension and improved endothelial vasodilatation through an increase of Cu/Zn SOD protein expression.
Topics: Acetylcholine; Administration, Oral; Animals; Antihypertensive Agents; Aorta; Arterioles; Disease Mo | 2004 |
Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats.
Topics: Acetic Acid; Animals; Dinoprostone; Disease Models, Animal; Drug Administration Schedule; Fibrosis; | 2003 |
Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspirin; Blood Pressure; Bradykinin; Disease Mode | 2003 |
Both selective COX-1 and COX-2 inhibitors aggravate gastric damage induced in rats by 2-deoxy-D-glucose. relation to gastric hypermotility and COX-2 expression.
Topics: Animals; Cyclooxygenase Inhibitors; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship | 2003 |
Pharmacological characterisation of a rat model of incisional pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Model | 2004 |
Hepatoprotective action of PGE1 analogue estimated by measuring the concentrations of acetoacetate and beta-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Disease; Administration, Oral; Alanine Transaminase; Ani | 2003 |
Sleep alterations in an experimental orofacial pain model in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cerebral C | 2003 |
Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Hydrochloric Acid; Hypo | 2003 |
Methimazole prevents stress and chemical induced gastropathy in rats.
Topics: Animals; Antithyroid Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Fema | 2003 |
Peri-sciatic administration of indomethacin early after nerve injury can attenuate the development of tactile allodynia in a rat model of L5 single spinal nerve injury.
Topics: Animals; Axotomy; Disease Models, Animal; Indomethacin; Lumbar Vertebrae; Male; Pain Measurement; Ph | 2004 |
Functional study of the [Ca2+]i signaling pathway in aortas of L-NAME-hypertensive rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Administration, Oral; Animals; Aorta, Thoracic; Caffein | 2004 |
In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin.
Topics: Animals; Biological Availability; Cornea; Delayed-Action Preparations; Disease Models, Animal; Indom | 2003 |
Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Bethanechol; Cimetidine; Diseas | 2004 |
The contractile response of the mesenteric resistance arteries to prostaglandin F2alpha; effects of simultaneous hyperlipemia-diabetes.
Topics: Aging; Animals; Blood Glucose; Cricetinae; Diabetes Mellitus, Experimental; Dinoprost; Disease Model | 2003 |
Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Biological Factors; Chlorides; Diabetes Mellitus, Experimen | 2004 |
Pathophysiology of vascular dysfunction in a rat model of chronic joint inflammation.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weigh | 2004 |
Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Colonic Neo | 2004 |
Contribution to safe anti-inflammatory therapy with indomethacin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis; Car | 2004 |
Antinociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test.
Topics: Analgesics; Animals; Cyclohexane Monoterpenes; Cyclohexenes; Disease Models, Animal; Drug Therapy, C | 2004 |
The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Citru | 2004 |
In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG).
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimy | 2004 |
[Prophylactic use of angiotensin-converting enzyme inhibitors in indomethacin-induced ulcer and erosion lesions of the stomach].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthriti | 2004 |
Ghrelin-a new gastroprotective factor in gastric mucosa.
Topics: Animals; Blotting, Western; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; | 2004 |
Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat.
Topics: Administration, Oral; Analysis of Variance; Animals; Anthocyanins; Anti-Inflammatory Agents, Non-Ste | 2004 |
Indomethacin blocks the nucleus pulposus-induced effects on nerve root function. An experimental study in dogs with assessment of nerve conduction and blood flow following experimental disc herniation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arteries; Disease Models, Animal; Dogs; Ganglia, S | 2004 |
Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Brimonidine Tartrate; Canada; Charybdotoxin; Coronary V | 2004 |
Aggravation of inflammatory bowel disease by cyclooxygenase-2 inhibitors in rats.
Topics: Animals; Celecoxib; Colon; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2004 |
Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cattle; Cimetidine; Disease Mod | 2004 |
Chronic gastritis rat model and role of inducing factors.
Topics: Alcohols; Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrophy; Chronic Disease; Deoxy | 2004 |
Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Chronic Disease; Cyclic GMP; Disease Mod | 2004 |
Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine.
Topics: Animals; Caffeine; Disease Models, Animal; Drug Therapy, Combination; Indomethacin; Male; Mice; Migr | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil.
Topics: Acetic Acid; Acyclic Monoterpenes; Administration, Inhalation; Administration, Oral; Analgesics; Ani | 2004 |
Effects of prostanoids on phenylephrine-induced contractions in the mesenteric vascular bed of rats with streptozotocin-induced diabetes mellitus.
Topics: Adrenergic alpha-Agonists; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Re | 2004 |
[Experimental assessment of the effect of dimephosphone on ulcerogenesis].
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Gastric Mucosa; Indomethacin; Intestine, Sm | 2004 |
Ursodeoxycholic acid ameliorates experimental ileitis counteracting intestinal barrier dysfunction and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Ileitis; Indomethacin; Int | 2004 |
Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Disease Models, Animal; Gastric Mucosa; | 2005 |
Indomethacin preserves muscle mass and reduces levels of E3 ligases and TNF receptor type 1 in the gastrocnemius muscle of tumor-bearing mice.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, We | 2005 |
Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Ce | 2005 |
Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bilirubin; Creatinine; Disease Models, Animal; Indomethacin; | 2005 |
Mechanisms underlying quercetin-induced vasorelaxation in aorta of subchronic diabetic rats: an in vitro study.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Model | 2004 |
Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip.
Topics: Animals; Anti-Ulcer Agents; Anticoagulants; Coumarins; Disease Models, Animal; Dose-Response Relatio | 2005 |
Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexia.
Topics: Animals; Base Sequence; Body Weight; Cachexia; Dinoprostone; Disease Models, Animal; DNA Primers; DN | 2005 |
Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Carcinoma, Squamous Cell; Celecoxib; Ce | 2005 |
Development and pharmacological characterization of a rat model of osteoarthritis pain.
Topics: Alkylating Agents; Analgesics, Opioid; Animals; Celecoxib; Cyclooxygenase Inhibitors; Disease Models | 2005 |
[Inflammatory ointment from shea butter and hydro-alcoholic extract of Khaya senegalensis barks (Cailcederat)].
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Croton Oil; Dexamethasone; Disease Mod | 2000 |
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Ani | 2005 |
Indomethacin-induced ileitis is associated with tensiometric, vascular and oxidative changes in the experimental rat model.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Carbachol; Cholinergic Agonists; Disease Models, | 2005 |
Role of sensory neuron in reduction of endotoxin-induced hypotension in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; C | 2005 |
Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharide.
Topics: alpha-MSH; Analysis of Variance; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic | 2005 |
Effect of indomethacin on motor activity and spinal cord free fatty acid content after experimental spinal cord injury in rabbits.
Topics: Animals; Disease Models, Animal; Fatty Acids, Nonesterified; Indomethacin; Motor Activity; Paraplegi | 2005 |
Therapeutic effect of D-002 (abexol) on gastric ulcer induced experimentally in rats.
Topics: Acetic Acid; Acute Disease; Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Chronic | 2005 |
Effect of indomethacin in endotoxin shock in the dog.
Topics: Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Dogs; Hematocrit; Indomethacin; P | 1967 |
Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats.
Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Dose-Response Relat | 2005 |
Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP.
Topics: Adenosine Triphosphate; Administration, Cutaneous; Administration, Oral; Analgesics, Non-Narcotic; A | 2005 |
Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Brain; Camphanes; Can | 2005 |
The effects of non-selective, preferential-selective and selective COX-inhibitors on the growth of experimental and human tumors in mice related to prostanoid receptors.
Topics: Amyloid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Line, Tumor; Cell Surviva | 2005 |
Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Area Under Curve; Camphanes; Can | 2005 |
Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents.
Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; | 2005 |
Orally administered FPRL1 receptor agonist peptide MMK-1 inhibits etoposide-induced alopecia by a mechanism different from intraperitoneally administered MMK-1.
Topics: Administration, Oral; Alopecia; Animals; Cimetidine; Disease Models, Animal; Etoposide; Female; Indo | 2006 |
An elemental diet controls inflammation in indomethacin-induced small bowel disease in rats: the role of low dietary fat and the elimination of dietary proteins.
Topics: Animals; Crohn Disease; Dietary Proteins; Disease Models, Animal; Food, Formulated; Gastrointestinal | 2005 |
Enhancement of transformed foci and induction of prostaglandins in Balb/c 3T3 cells by palytoxin: in vitro model reproduces carcinogenic responses in animal models regarding the inhibitory effect of indomethacin and reversal of indomethacin's effect by ex
Topics: Acrylamides; Animals; BALB 3T3 Cells; Carcinogens; Cell Transformation, Neoplastic; Cnidarian Venoms | 2006 |
Cyclical upregulated iNOS and long-term downregulated nNOS are the bases for relapse and quiescent phases in a rat model of IBD.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Gastrointestin | 2006 |
Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer model in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fats, Unsaturated; D | 2005 |
The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Dinoprostone; | 2005 |
Modulation of gastric hemorrhage and ulceration by oxidative stress and histamine release in Salmonella typhimurium-infected rats.
Topics: Allopurinol; Animals; Antioxidants; Dimethyl Sulfoxide; Disease Models, Animal; Gastric Juice; Gastr | 2005 |
Free arachidonic versus eicosapentaenoic acid differentially influences the potency of bacterial exotoxins to provoke myocardial depression in isolated rat hearts.
Topics: Animals; Arachidonic Acid; Bacterial Toxins; Disease Models, Animal; Drug Interactions; Eicosapentae | 2006 |
Renal effects of human urotensin-II in rats with experimental congestive heart failure.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Glomerular Filtration Rate; Heart Failure; He | 2006 |
Anti-inflammatory activity of alkanoids and triterpenoids from Trichodesma amplexicaule Roth.
Topics: Alkanes; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Biological Assay; Boraginaceae; | 2006 |
Acetazolamide interferes with the protective effect of prostaglandin E2 in the rat gastric mucosa.
Topics: Acetazolamide; Alkalies; Animals; Carbonic Anhydrase Inhibitors; Cyclooxygenase Inhibitors; Dinopros | 1981 |
Endothelium-dependent inhibition of the contractile response is decreased in aorta from aged and spontaneously hypertensive rats.
Topics: Aging; Animals; Aorta; Disease Models, Animal; Endothelium; Hypertension; Indomethacin; Male; Muscle | 2006 |
Influence of cyclooxygenase inhibitors on gut immune cell distribution and apoptosis rate in experimental sepsis.
Topics: Animals; Apoptosis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, A | 2006 |
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrasentan; Bosentan; Carrageenan; Celecoxib; Cold | 2006 |
Somatic pain sensitivity during formation and healing of acetic acid-induced gastric ulcers in conscious rats.
Topics: Acetic Acid; Adrenal Glands; Animals; Anti-Inflammatory Agents, Non-Steroidal; Consciousness; Cortic | 2006 |
Role of bile acids, prostaglandins and COX inhibitors in chronic esophagitis in a mouse model.
Topics: Animals; Bile Acids and Salts; Chronic Disease; Cyclooxygenase Inhibitors; Dinoprostone; Disease Mod | 2006 |
Influence of indomethacin in the rat aneurysm model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Aortic Ane | 2006 |
Indomethacin enhances bile salt detergent activity: relevance for NSAIDs-induced gastrointestinal mucosal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Biological Transport; Diseas | 2006 |
Deoxycorticosterone's anticonvulsant effects in infant rats are blocked by finasteride, but not by indomethacin.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Dose-Respo | 2006 |
Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats.
Topics: Animals; Antithrombins; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Calciton | 2006 |
Anti-inflammatory treatment in oxygen-glucose-deprived hippocampal slice cultures is neuroprotective and associated with reduced cell proliferation and intact neurogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cell Division; Cytokines; Disease | 2006 |
Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Progression; Electrophoresis, Polyacrylamide Ge | 2006 |
[Angiotensin II AT1 receptor antagonists as antiinflammatory and gastric protection drugs].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Benzimidazoles; Biphenyl | 2006 |
Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants.
Topics: Animals; Antioxidants; Collagenases; Disease Models, Animal; DNA Primers; Enzyme Precursors; Gene Ex | 2006 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoproston | 2006 |
Involvement of cyclooxygenase-2 in allergic nasal inflammation in rats.
Topics: Animals; Carbazoles; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Electroenc | 2006 |
Cyclooxygenase system contributes to the maintenance of post convulsive period of epileptic phenomena in the genetically epileptic El mice.
Topics: Animals; Cerebral Cortex; Cyclooxygenase 2; Disease Models, Animal; Epilepsy; Indomethacin; Injectio | 2006 |
Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency.
Topics: alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Animals; Anti-Inflammatory Agents, Non-Steroida | 2006 |
Role of endogenous nitric oxide (NO) and NO synthases in healing of indomethacin-induced intestinal ulcers in rats.
Topics: Animals; Disease Models, Animal; Duodenal Ulcer; Enzyme Inhibitors; Gene Expression Regulation, Enzy | 2007 |
Rat pain-related responses induced by experimental scorpion BmK sting.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacain | 2006 |
Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation?
Topics: Adult; Animals; Case-Control Studies; Colon; Crohn Disease; Dietary Supplements; Disease Models, Ani | 2006 |
Trefoil factor 2 in gland mucous cell mucin in the mucous gel covering normal or damaged gastric mucosa using the Mongolian gerbil model.
Topics: Animals; Disease Models, Animal; Ethanol; Gastric Mucins; Gastric Mucosa; Gerbillinae; Helicobacter | 2006 |
Chronic cyclooxygenase blockade enhances the vasopressin responsiveness in collaterals of portal hypertensive rats.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Collateral Circulation; Cyclooxygenase Inhibitors; Di | 2006 |
Free radical scavengers are more effective than indomethacin in the prevention of experimentally induced heterotopic ossification.
Topics: Acetylcysteine; Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Anima | 2007 |
Effect of Brazilian green propolis on experimental gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Brazil; Complex Mixtures; Disease Models, Animal; Dose-Response Relation | 2007 |
Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, | 2007 |
Peripheral sympathetic component of the temporomandibular joint inflammatory pain in rats.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease | 2006 |
Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Diabetes M | 2006 |
Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice.
Topics: Animals; Animals, Newborn; Brain; Cerebral Palsy; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinop | 2007 |
In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems in different models of gastrointestinal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Ethanol; Gas | 2007 |
Anti-inflammatory activity of bis(3-aryl-3-oxo-propyl)methylamine hydrochloride in rat.
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Cell Proliferation; Cotton F | 2007 |
Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetamides; Animals; Anti-Ulcer Agents; Arachidonic Acids; Calcitonin | 2007 |
Modifications produced by indomethacin and L-NAME in the effect of ultralow-dose aspirin on platelet activity in portal hypertension.
Topics: Animals; Aspirin; Blood Coagulation Tests; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug I | 2006 |
Effect of acetyl 11-keto beta-boswellic acid on metastatic growth factor responsible for angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Collagen; Cyclooxygenase Inhibi | 2007 |
Contributions of histamine, prostanoids, and neurokinins to edema elicited by edema toxin from Bacillus anthracis.
Topics: Animals; Antigens, Bacterial; Aprepitant; Bacillus anthracis; Bacterial Toxins; Capillary Permeabili | 2007 |
Walker 256 tumor-bearing rats as a model to study cancer pain.
Topics: Animals; Carcinoma; Cell Line, Tumor; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethaci | 2007 |
Pathogenesis of spinally mediated hyperalgesia in diabetes.
Topics: Aldehyde Reductase; Animals; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Disease Models, Anim | 2007 |
An operant conditioning model to assess changes in feeding behavior associated with temporomandibular joint inflammation in the rat.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; B | 2007 |
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat.
Topics: Administration, Oral; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Ani | 2007 |
Lactobacillus rhamnosus GG exacerbates intestinal ulceration in a model of indomethacin-induced enteropathy.
Topics: Animals; Apoptosis; Bifidobacterium; Cell Proliferation; Disease Models, Animal; Indomethacin; Intes | 2007 |
Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Experimental; Bone and Bo | 2007 |
Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cytokines; Disease Models | 2007 |
Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Centra | 2007 |
Indomethacin reduces short-circuit current and oxygen consumption in normal and chronically hypoxic rat colon.
Topics: Animals; Colon; Cyclooxygenase Inhibitors; Disease Models, Animal; Hypoxia; Indomethacin; Male; Oxyg | 2006 |
Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats.
Topics: Animals; Cardiovascular Diseases; Celecoxib; Colitis, Ulcerative; Colon; Cyclooxygenase 1; Cyclooxyg | 2007 |
Modulation of aortic vascular reactivity by sex hormones in a male rat model of metabolic syndrome.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Estradiol; Gonadal St | 2007 |
5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blotting, Western; Cyclooxygenase Inhi | 2008 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamid | 2008 |
Local delivery of indomethacin to arthritis-bearing rats through polymeric micelles based on amphiphilic polyphosphazenes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Ca | 2007 |
Medicinal flowers. XVI. New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng.
Topics: Animals; Dammaranes; Disease Models, Animal; Ethanol; Flowers; Gastrointestinal Agents; Glycosides; | 2007 |
Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Brazil; Cimetidine; Disease Mod | 2007 |
Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Catechols; Disease Models, Animal; DNA; Gastric | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenas | 2007 |
Comparison of pre- versus post-incision administration of intraplantar indomethacin and MK886 in a rat model of postoperative pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Therapy, Combination; | 2007 |
Gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal injury in rats: a preliminary study.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnitine; Chemoprevention; | 2006 |
Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats.
Topics: Animals; Astrocytes; Brain Ischemia; Carotid Stenosis; Cyclooxygenase Inhibitors; Disease Models, An | 2007 |
Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site.
Topics: Acetylcysteine; Administration, Topical; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents | 2008 |
Antibiotics protect against septic shock in mice administered beta-glucan and indomethacin.
Topics: Animals; Anti-Bacterial Agents; Bacterial Translocation; beta-Glucans; Body Weight; Colon; Cytokines | 2007 |
The effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures. An experimental study in rabbits.
Topics: Analysis of Variance; Animals; Bony Callus; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Fra | 2007 |
Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Biological Factors; Blood Glucose; Body Weight; Cha | 2008 |
Advantages of mixed effects models over traditional ANOVA models in developmental studies: a worked example in a mouse model of fetal alcohol syndrome.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bias; Body Weight; Brain; Disease Models, Animal; E | 2007 |
Effects of the selective prostacyclin receptor antagonist RO3244019 on the micturition reflex in rats.
Topics: Animals; Capsaicin; Disease Models, Animal; Female; Indomethacin; Random Allocation; Rats; Rats, Spr | 2007 |
Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Diclofen | 2007 |
Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; | 2007 |
Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease | 2008 |
The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease M | 2007 |
Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model.
Topics: Amnion; Amniotic Fluid; Ampicillin; Animals; Anti-Bacterial Agents; Cesarean Section; Chorioamnionit | 2007 |
Indomethacin and retinoic acid modify mouse intestinal inflammation and fibrosis: a role for SPARC.
Topics: Animals; Crohn Disease; Disease Models, Animal; Female; Fibrosis; Immunoenzyme Techniques; Indometha | 2008 |
A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Dexamethasone | 2007 |
Effects of progesterone on FSH-stimulated indomethacin ulcers in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogens; Female; Follicle Stimu | 2008 |
The effects of prostaglandin inhibition on whole-body ischemia-reperfusion in swine.
Topics: Animals; Cardiopulmonary Resuscitation; Celecoxib; Cyclooxygenase Inhibitors; Dinoprostone; Disease | 2008 |
Prostaglandin inhibition and ischemia: where are the data?
Topics: Animals; Cardiopulmonary Resuscitation; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal | 2008 |
Topical anti-inflammatory activities of Vitis rotundifolia (muscadine grape) extracts in the tetradecanoylphorbol acetate model of ear inflammation.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Female; F | 2007 |
Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, An | 2007 |
Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets.
Topics: Alanine; Analysis of Variance; Animals; Animals, Newborn; Arginine; Atrophy; Chlorides; Cryptosporid | 2008 |
Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Blotting, Western; Dendritic Cells; | 2008 |
A novel model of pain sensation using superfused gastrosplenic omentum preparation of anesthetized rats.
Topics: Analgesics, Non-Narcotic; Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressu | 2008 |
Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodieste | 2008 |
Characterization of a model of chronic orofacial hyperalgesia in the rat: contribution of NA(V) 1.8.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-R | 2008 |
Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch.
Topics: Adenosine Deaminase; Animals; Carrageenan; Dexamethasone; Disease Models, Animal; Immunosuppressive | 2008 |
Protective effect of octreotide and infliximab in an experimental model of indomethacin-induced inflammatory bowel disease.
Topics: Animals; Antibodies, Monoclonal; Cell Membrane Permeability; Crohn Disease; Disease Models, Animal; | 2008 |
Role of phospholipase A2 and tyrosine kinase in Clostridium difficile toxin A-induced disruption of epithelial integrity, histologic inflammatory damage and intestinal secretion.
Topics: Animals; Bacterial Toxins; Cell Line, Tumor; Disease Models, Animal; Drug Combinations; Enterotoxins | 2008 |
Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice.
Topics: Animals; Anti-Inflammatory Agents; Benzopyrans; Disease Models, Animal; Ear; Edema; Emericella; Fema | 2008 |
Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catechols; Cyclooxygenase 1; Cyclooxygenase 2; Dinoproston | 2008 |
Permeation studies of indomethacin from different emulsions for nasal delivery and their possible anti-inflammatory effects.
Topics: Administration, Intranasal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cetomacro | 2008 |
Association of tumor necrosis factor, interleukin-6 and cyclooxygenase pathway with lipopolysaccharide-induced intussusception.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Indomethacin; Interleukin-6; Int | 2008 |
Prostaglandin E2-mediated dysregulation of proinflammatory cytokine production in pristane-induced lupus mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Concanavalin A; Cyclooxygenase Inhibitors; C | 2008 |
In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI.
Topics: Androstadienes; Animals; Anti-Inflammatory Agents; Aza Compounds; Benzamides; Bronchoalveolar Lavage | 2008 |
Effects of various pharmacologic agents on allergic inflammation of the eye. The roles of chemical mediators in ocular inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antigen-Antibody Reactions; Aqueous Humor; Arthus Reaction; Disea | 1980 |
The mode of action of analgesic drugs in adjuvant arthritic rats as an experimental model of chronic inflammatory pain: possible central analgesic action of acidic nonsteroidal antiinflammatory drugs.
Topics: Aminopyrine; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthri | 1984 |
Do prostaglandins mediate the somatostatin preventive effect on gastric lesion?
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Male; Prostaglandins; Rats | 1984 |
Interferon induction and prostaglandin synthetase inhibition in the in vitro and in vivo manipulation of immune response expression in an animal model of bladder cancer.
Topics: Animals; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Disease Models, Animal; Immunity, Cel | 1982 |
The late phase skin reaction: paradigm or epiphenomena?
Topics: Adrenal Cortex Hormones; Animals; Arthus Reaction; Chemotaxis, Leukocyte; Dermatitis, Atopic; Diseas | 1983 |
The effect of naloxone in different gastroduodenal ulcer models.
Topics: Animals; Cysteamine; Disease Models, Animal; Female; Gastric Mucosa; Indomethacin; Male; Naloxone; P | 1983 |
Lithium chloride: protective and antisecretory properties in rats.
Topics: Animals; Chlorides; Dinoprostone; Disease Models, Animal; Drug Evaluation; Ethanol; Gastric Acid; Ga | 1984 |
Pharmacological prevention of ocular inflammation induced by lens proteins.
Topics: Aminopyridines; Animals; Catechols; Cimetidine; Crystallins; Disease Models, Animal; Drug Therapy, C | 1984 |
Effects of indomethacin in conscious dogs with experimental high-output heart failure.
Topics: Animals; Blood Pressure; Dinoprostone; Disease Models, Animal; Dogs; Female; Heart; Heart Failure; H | 1983 |
Inhibition of prostaglandin synthesis restores normal hemodynamics in canine hyperdynamic sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Dogs; Escherichia coli Infections; Fe | 1984 |
An experimental model of nephritis induced by calf serum injection in mice.
Topics: Animals; Anti-Inflammatory Agents; Blood Cell Count; Body Weight; Cyclophosphamide; Dexamethasone; D | 1984 |
Correlation between ossification and inflammation using a rat experimental model.
Topics: Animals; Arthritis; Arthritis, Experimental; Disease Models, Animal; Indomethacin; Naproxen; Ossific | 1983 |
Progressive foot swelling in BUF rats. A new animal model for screening of anti-inflammatory and anti-rheumatic drugs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Cyclophosphamide; Dexamethaso | 1984 |
[Re-evaluation of the carrageenin-induced abscess model as a screening method for anti-inflammatory agents].
Topics: Abscess; Animals; Anti-Inflammatory Agents; Carrageenan; Dexamethasone; Disease Models, Animal; DNA; | 1984 |
[Formalin-induced minor tremor response as an indicator of pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Carrageenan; Disease Models, Animal; Dose-Response Relati | 1984 |
Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology.
Topics: Animals; Capillary Permeability; Cyproheptadine; Disease Models, Animal; Dose-Response Relationship, | 1984 |
Ultrastructural and pharmacologic studies on laser-induced glaucoma in primates and rabbits.
Topics: Animals; Disease Models, Animal; Epinephrine; Glaucoma; Indomethacin; Intraocular Pressure; Lasers; | 1984 |
Acute intraocular pressure elevation produced by argon laser trabeculoplasty in the cynomolgus monkey.
Topics: Animals; Disease Models, Animal; Female; Indomethacin; Inflammation; Laser Therapy; Lasers; Macaca f | 1984 |
Decreased contractility of the ductus arteriosus in experimental pulmonic stenosis.
Topics: Animals; Dinoprostone; Disease Models, Animal; Ductus Arteriosus; Female; Hemodynamics; Indomethacin | 1984 |
Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages.
Topics: Animals; Catalase; Cell Separation; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Human | 1984 |
[Immunomodulation by symptomaticly active antirheumatic agents].
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Autoradiography; Dexamethasone; Disease Models, Animal | 1983 |
Beagle puppy model of intraventricular hemorrhage: randomized indomethacin prevention trial.
Topics: Animals; Animals, Newborn; Blood Pressure; Cerebral Hemorrhage; Cerebral Ventricles; Cerebrovascular | 1983 |
The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats.
Topics: Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Aspirin; Coronary Vessels; Disease Models, | 1984 |
[Experimental models for peptic ulcer].
Topics: Animals; Aspirin; Disease Models, Animal; Dogs; Histamine; Immersion; Indomethacin; Peptic Ulcer; Ra | 1984 |
Bleeding time in rats: a comparison of different experimental conditions.
Topics: Anesthetics; Animals; Aspirin; Bleeding Time; Blood Coagulation; Blood Platelet Disorders; Dipyridam | 1982 |
Indomethacin improves survival in gram-negative sepsis.
Topics: Animals; Blood Pressure; Disease Models, Animal; Escherichia coli Infections; Indomethacin; Leukocyt | 1981 |
Canine lymphosarcoma: a model for study of the hypercalcemia of cancer.
Topics: Animals; Antineoplastic Agents; Aspirin; Bone Resorption; Calcium; Disease Models, Animal; Dog Disea | 1980 |
Comparison of the anti-inflammatory effects of dexamethasone, indomethacin and BW755C on carrageenin-induced pleurisy in rats.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Car | 1982 |
The salvage of ischaemic myocardium by BW755C in anaesthetised dogs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Cor | 1982 |
Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow.
Topics: Animals; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; D | 1983 |
Indomethacin improvement of septic acute respiratory failure in a porcine model.
Topics: Acute Disease; Animals; Disease Models, Animal; Hemodynamics; Indomethacin; Lung; Male; Respiratory | 1983 |
Nb rat prostate adenocarcinoma model androgen-sensitive tumor: metastasis control.
Topics: Adenocarcinoma; Animals; Castration; Cyclophosphamide; Disease Models, Animal; Heparin; Indomethacin | 1983 |
The effect of prostaglandin precursors in in vivo models of cell-mediated immunity.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Essential | 1981 |
[Comparison of the effect of 3-amino-4-mercapto-6-methylpyridazine with various antiphlogistic agents in rat models of inflammation].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Di | 1982 |
The rat with spontaneous genetic hypertension is not a suitable model of human essential hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Genotype; Humans; Hypertension; Indomethacin; Kidne | 1981 |
Experimental cerebral ischemia produced by extracranial vascular injury: protection with indomethacin and prostacyclin.
Topics: Animals; Carotid Arteries; Disease Models, Animal; Electroshock; Epoprostenol; Indomethacin; Ischemi | 1982 |
Improved survival in the suckling rat model of group B streptococcal sepsis after treatment with nonsteroidal anti-inflammatory drugs.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Humans; Ibuprofen; Indomethacin; Infant, Newborn; | 1982 |
Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation?
Topics: Animals; Aspirin; Constriction, Pathologic; Coronary Angiography; Coronary Circulation; Coronary Dis | 1982 |
Role of food in gastrointestinal ulceration produced by indomethacin in the rat.
Topics: Animals; Diet; Disease Models, Animal; Feeding Behavior; Female; Food; Indomethacin; Intestine, Smal | 1982 |
A biochemical study of the cotton pellet granuloma in the rat. Effects of dexamethasone and indomethacin.
Topics: Acetylglucosaminidase; Animals; Dexamethasone; Disease Models, Animal; Gossypium; Granuloma; Indomet | 1982 |
Oleic-acid-induced lung injury in the rat. Failure of indomethacin treatment or complement depletion to ablate lung injury.
Topics: Animals; Complement C3; Complement System Proteins; Disease Models, Animal; Elapid Venoms; Indometha | 1981 |
Spontaneous activity in the trachea of dogs treated with indomethacin: an experimental model for aspirin-related asthma.
Topics: Animals; Aspirin; Asthma; Atropine; Disease Models, Animal; Dogs; Female; Indomethacin; Male; Muscle | 1981 |
The effects of levamisole and D-penicillamine on some inflammatory models in vivo and on PG production in vitro.
Topics: Animals; Disease Models, Animal; Edema; In Vitro Techniques; Indomethacin; Inflammation; Leukocytes; | 1981 |
Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin.
Topics: Animals; Aqueous Humor; Betamethasone; Conjunctivitis; Dexamethasone; Disease Models, Animal; Eye; H | 1981 |
Effects of raised intraluminal pressure on gallbladder function and hepatic bile outflow in the cat.
Topics: Animals; Bile; Cats; Cholecystitis; Cholestasis; Disease Models, Animal; Gallbladder; Indomethacin; | 1981 |
Study of antiulcer activity of aqueous extract of leaves of Pyrenacantha staudtii (family Icacinaceae) using various models of experimental gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Female; Indomethacin; Male; Nigeria; Pl | 1981 |
Anti-inflammatory action of topical indomethacin.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Aqueous Humor; Disease Models, Animal; E | 1980 |
The local anti-inflammatory activity of rimexolone (Org 6216) in fibrin-induced monoarticular arthritis and adjuvant-induced arthritis.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Dise | 1980 |
Ischemia-induced canine myocardial lysosome labilization: the role of endogenous prostaglandins and cyclic nucleotides.
Topics: Acid Phosphatase; Animals; Coronary Disease; Disease Models, Animal; Dogs; Indomethacin; Intracellul | 1980 |
Failure of indomethacin to prevent or ameliorate oleic acid pulmonary edema in the dog.
Topics: Animals; Disease Models, Animal; Dogs; Indomethacin; Oleic Acids; Prostaglandins; Pulmonary Edema; R | 1980 |
Three day pleural inflammation: a new model to detect drug effects on macrophage accumulation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dexamethasone; Disease Models, Animal; Indomethacin; | 1980 |
["Granuloma pouch" reduction after treatment with indomethacin and diflunisal and collateral effects of these drugs on gastric mucosa].
Topics: Animals; Diflunisal; Disease Models, Animal; Gastric Mucosa; Granuloma; Indomethacin; Male; Rats; Sa | 1980 |
Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats.
Topics: Administration, Oral; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; | 1995 |
Comparison of cholecystokinin, pentagastrin, and duodenal oleate in gastroprotection in rats.
Topics: Animals; Cholecystokinin; Disease Models, Animal; Ethanol; Gastric Juice; Gastric Mucosa; Gastrointe | 1995 |
[The anti-arrhythmia effect of Rhodiola rosea and its possible mechanism].
Topics: Animals; Anti-Arrhythmia Agents; Calcium Chloride; Cardiac Complexes, Premature; Disease Models, Ani | 1993 |
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cholic Acids; Dinoprostone; Disease Models, Animal; H | 1994 |
Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats.
Topics: Animals; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Mucins; Hydralazine; Indomethacin; M | 1994 |
Magnesium modulates endothelial dysfunction produced by elevated glucose incubation.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta; Diabetes Mellitus, Experimental; Disease Models | 1994 |
Alterations of ex vivo vascular reactivity in intraperitoneal sepsis.
Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Body Temperature; Cecum; Disease Models, Animal; D | 1994 |
Effect of nonapeptide fragments of uteroglobin and lipocortin I on oedema and mast cell degranulation.
Topics: Animals; Annexin A1; Aristolochic Acids; Carrageenan; Cell Degranulation; Chlorpheniramine; Dexameth | 1994 |
Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin.
Topics: Adrenalectomy; Animals; Anthraquinones; Bradykinin; Capillary Permeability; Cell Degranulation; Dexa | 1995 |
Antiulcer activity of Pteleopsis suberosa.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Indomethacin; Male; Medicine, Tradition | 1995 |
Impairment of endothelium-dependent vasorelaxation in chronic two-kidney, one clip hypertensive rats.
Topics: Acetylcholine; Animals; Arginine; Atrial Natriuretic Factor; Chronic Disease; Disease Models, Animal | 1995 |
Measurement and drug induced modulation of interleukin-1 level during zymosan peritonitis in mice.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bi | 1995 |
Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Dehydroepiandrosterone; Disease Models, Animal; Hyperplasia; Indom | 1995 |
Leucocyte-endothelial cell adhesion in a model of intestinal inflammation.
Topics: Animals; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Disease Models, Anima | 1995 |
Protection by almagate of ethanol-induced gastric mucosal damage in rats.
Topics: Administration, Oral; Aluminum Hydroxide; Animals; Antacids; Carbonates; Disease Models, Animal; Dos | 1995 |
Role of pepsin in the development of indomethacin-induced antral ulceration in the rat.
Topics: Animals; Disease Models, Animal; Drug Interactions; Female; Gastric Mucosa; Indomethacin; Methylcell | 1995 |
Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fish Oils; Gastric Aci | 1995 |
15-Hydroxyeicosatetraenoic acid and diabetic endothelial dysfunction in rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 | 1995 |
[Acute kidney failure related to the use of x-ray contrast agents and indomethacin: the risk factors and mechanisms of its development].
Topics: Acute Kidney Injury; Animals; Diatrizoate Meglumine; Diet, Sodium-Restricted; Disease Models, Animal | 1995 |
Effect of anti-inflammatory agent etodolac on antigen-induced contractions of the trachea and lung parenchyma of guinea pigs.
Topics: Animals; Asthma; Benzoquinones; Disease Models, Animal; Etodolac; Guinea Pigs; Immunization, Passive | 1994 |
Hyaluronic acid modulates acute and chronic inflammation.
Topics: Acute Disease; Animals; Arthritis, Experimental; Carrageenan; Chronic Disease; Disease Models, Anima | 1994 |
Effect of pumpkin-seed oil on the level of free radical scavengers induced during adjuvant-arthritis in rats.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Free Radical Scavengers; Glutathione; Indo | 1995 |
Antinociceptive properties of protein C in a model of inflammatory hyperalgesia in rats.
Topics: Animals; Antibodies, Monoclonal; Basal Metabolism; Carrageenan; Disease Models, Animal; Female; Hype | 1995 |
Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Benzamides; Benzopyra | 1994 |
Acute lung injury isolated to an in situ lung preparation causes sustained reflex cardiovascular depression in dogs.
Topics: Animals; Atropine; Blood Gas Analysis; Blood Pressure; Denervation; Disease Models, Animal; Dogs; He | 1994 |
Role of indomethacin-induced peptic ulceration in gastric acid secretion in pregnant rats.
Topics: Animals; Carbachol; Disease Models, Animal; Female; Gastric Acid; Histamine; Indomethacin; Peptic Ul | 1993 |
An experimental model of osteoarthritis in rabbit.
Topics: Animals; Aspirin; Disease Models, Animal; Indomethacin; Male; Osteoarthritis; Rabbits | 1994 |
Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate.
Topics: Animals; Capillary Permeability; Catheterization; Disease Models, Animal; Fluorescein Angiography; F | 1995 |
Effects of the acetylene compound from Atractylodes rhizome on experimental gastric ulcers induced by active oxygen species.
Topics: Acetylene; Administration, Oral; Alkynes; Animals; Anti-Ulcer Agents; Disease Models, Animal; Diynes | 1994 |
Possibilities to evaluate and diminish the effects of the trauma in spinal cord lesions. An experimental study in the rat.
Topics: Animals; Disease Models, Animal; Evoked Potentials; Indomethacin; Naloxone; Neural Conduction; Nimod | 1994 |
Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Electrosh | 1993 |
Mechanisms of acute and chronic intestinal inflammation induced by indomethacin.
Topics: Acute Disease; Animals; Bacteria; Bile; Chronic Disease; Disease Models, Animal; Enteritis; Indometh | 1993 |
Aggressive role of vasopressin in development of different gastric lesions in rats.
Topics: Animals; Arginine Vasopressin; Autoradiography; Cold Temperature; Disease Models, Animal; Dose-Respo | 1994 |
WEB-2086 and indomethacin do not modify blood pressure fall on unclipping hypertensive rats.
Topics: Animals; Azepines; Blood Pressure; Disease Models, Animal; Hypertension, Renal; Indomethacin; Inject | 1994 |
Protective effect of cisapride against indomethacin-induced obstruction of the gastric mucosal hemodynamics in rats.
Topics: Animals; Cisapride; Disease Models, Animal; Drug Interactions; Gastric Mucosa; Gastrointestinal Moti | 1994 |
[Regulation of osteoclastic resorption by prostanoids in vivo].
Topics: Animals; Bone Resorption; Cell Differentiation; Disease Models, Animal; Dose-Response Relationship, | 1993 |
Regulation of blood flow in pulmonary microcirculation by vasoactive arachidonic acid metabolites--analysis in acute lung injury.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Dogs; Embolism, Fat; Epoprostenol; Female; Hypox | 1994 |
[Effect of indomethacin on endocrine kinetics of the stomach in experimental pyloric stenosis model].
Topics: Administration, Oral; Animals; Disease Models, Animal; Gastric Mucosa; Gastrins; Indomethacin; Male; | 1993 |
Selective hyperresponsiveness to ovalbumin-induced epithelial transport in inflamed guinea pig distal colon.
Topics: Animals; Antigens; Chlorpheniramine; Colitis; Cyclooxygenase Inhibitors; Disease Models, Animal; Epi | 1993 |
Novel photodynamic effects of a benzophenothiazine on two different murine sarcomas.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry, Physical; Disease Mode | 1994 |
Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Cerebral Cortex; Disease Models, Ani | 1993 |
Flurbiprofen effects on bone resorption.
Topics: Analysis of Variance; Animals; Bone and Bones; Bone Resorption; Disease Models, Animal; Fetus; Flurb | 1993 |
Spinal cord injury in the rat: treatment with bacterial lipopolysaccharide and indomethacin enhances cellular repair and locomotor function.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Indomethacin; Lipopolysaccharide | 1994 |
Effect of two nonsteroidal antiinflammatory drugs on heterotopic bone formation in a rabbit model.
Topics: Animals; Disease Models, Animal; Indomethacin; Ossification, Heterotopic; Piroxicam; Rabbits; Random | 1994 |
Dose-effect and evidence of escape of inhibition after indomethacin treatment in a synchronized model of bone resorption.
Topics: Animals; Bone Remodeling; Bone Resorption; Disease Models, Animal; Dose-Response Relationship, Drug; | 1993 |
Human colostrum has anti-inflammatory activity in a rat subcutaneous air pouch model of inflammation.
Topics: Animals; Carrageenan; Colostrum; Dexamethasone; Disease Models, Animal; Female; Humans; Indomethacin | 1993 |
Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Dose-Response | 1993 |
The effect of ebselen on polymorphonuclear leukocyte migration to joints in rats with adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Experimental; Azoles; Cel | 1993 |
Bradykinin initiates cytokine-mediated inflammatory hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atenolol; Bradykinin; Carrageenan; Cytokines; Dise | 1993 |
Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Bronchial Hyper | 1993 |
Lipopolysaccharide alters suckling rat liver glycogenolysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Cytarabine; Disease Models | 1993 |
A rabbit model for ascending infection in pregnancy: intervention with indomethacin and delayed ampicillin-sulbactam therapy.
Topics: Ampicillin; Animals; Chorioamnionitis; Disease Models, Animal; Drug Therapy, Combination; Escherichi | 1993 |
Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation.
Topics: Acetophenones; Animals; Antigen-Antibody Complex; Arachidonic Acid; Cell Movement; Dexamethasone; Di | 1993 |
Bronchopulmonary responses to endothelin-1 in sensitized and challenged guinea-pigs: role of cyclooxygenase metabolites and platelet-activating factor.
Topics: Aerosols; Animals; Azepines; Bronchi; Disease Models, Animal; Endothelins; Glycopeptides; Guinea Pig | 1993 |
Impaired endothelium-dependent coronary microvascular relaxation after cold potassium cardioplegia and reperfusion.
Topics: Acetylcholine; Aminoquinolines; Animals; Bradykinin; Calcimycin; Coronary Vessels; Disease Models, A | 1993 |
Stimulation of endogenous prostacyclin protects the reperfused pig myocardium from ischemic injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Platelets; Cyclooxygenase Inhibitors; Disease Models, A | 1993 |
Effects of cyclooxygenase and lipoxygenase inhibition on eicosanoids and healing of acetic acid colitis in rats.
Topics: Acetates; Acetic Acid; Analysis of Variance; Animals; Benzoquinones; Colitis; Colon; Cyclooxygenase | 1993 |
Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats.
Topics: Animals; Chronic Disease; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Phosp | 1993 |
An animal model of longitudinal ulcers in the small intestine induced by intracolonically administered indomethacin in rats.
Topics: Animals; Cecal Diseases; Colon; Disease Models, Animal; Duodenal Ulcer; Indomethacin; Intestinal Muc | 1993 |
Macrolide antibiotics as antiinflammatory agents: roxithromycin in an unexpected role.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Croton Oil; Dis | 1993 |
Thromboxanes, indomethacin, and experimental colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Indomethacin; Rats; Thro | 1993 |
Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism.
Topics: Animals; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Disease Models, Animal; Dose-Re | 1993 |
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole; | 1995 |
Anti-ulcer activity of higher primary alcohols of beeswax.
Topics: Administration, Oral; Alcohols; Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Etha | 1995 |
Pharmacologic characterization of wool dust extract in isolated guinea pig trachea.
Topics: Air Pollutants, Occupational; Animals; Atropine; Bronchoconstriction; Calcium Channel Blockers; Cycl | 1995 |
Repeated administration of low-dose lipopolysaccharide induces preterm delivery in mice: a model for human preterm parturition and for assessment of the therapeutic ability of drugs against preterm delivery.
Topics: Animals; Disease Models, Animal; Escherichia coli; Female; Gabexate; Glycoproteins; Humans; Indometh | 1996 |
Ketotifen is protective against indomethacin-induced intestinal ulceration in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Disease Models | 1996 |
Limiting lipid peroxidation in the nonischemic zone of infarcted rat hearts by indomethacin improves left ventricular function without affecting myocardial healing and remodeling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coronary Vessels; Disease Models, Animal; Indometh | 1996 |
Mast cells do not contribute to nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rodents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Dexa | 1996 |
Effect of cyclo-oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide-induced neutrophil infiltration in mouse lung.
Topics: Administration, Inhalation; Animals; Antifungal Agents; Aspirin; Bronchoalveolar Lavage Fluid; Cycli | 1996 |
Group B streptococcal sepsis impairs cerebral vascular reactivity to acute hypercarbia in piglets.
Topics: Animals; Blood Pressure; Brain; Carbon Monoxide; Carotid Artery, Internal; Disease Models, Animal; H | 1996 |
Mode of food intake reduction in Lewis rats with indomethacin-induced ulcerative ileitis.
Topics: Animals; Anorexia; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cells, Cultured; Dinoprosto | 1996 |
Effect of cyclo-oxygenase inhibition on in vitro B-cell function after burn injury.
Topics: Animals; Antibody Specificity; Antigens, Bacterial; B-Lymphocytes; Burns; Cell Division; Cyclooxygen | 1996 |
Role of adenosine and nitric oxide in the hyperemic response to superficial and deep gastric mucosal injury and H+ back-diffusion in cats.
Topics: Adenosine; Animals; Cats; Diffusion; Disease Models, Animal; Gastric Acidity Determination; Gastric | 1996 |
[Pathophysiological study on the mucosal defense system of genetically obese Zucker rats].
Topics: Animals; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Emptying; Gastric Mucosa; Indomethac | 1996 |
Anti-inflammatory and antiulcer activity of Teucrium buxifolium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Experimental; Carrag | 1997 |
Gastric antiulcer and cytoprotective effect of Commiphora molmol in rats.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism | 1997 |
Endothelial calcium-calmodulin dependent nitric oxide synthase in the in vitro vascular hyporeactivity of portal hypertensive rats.
Topics: Animals; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cyclooxygenase Inhibitors; D | 1997 |
Effects of Cistus laurifolius L. flowers on gastric and duodenal lesions.
Topics: Animals; Anti-Ulcer Agents; Cysteamine; Disease Models, Animal; Ethanol; Female; Gastric Acid; Indom | 1997 |
Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen | 1997 |
Flavonoid-induced gastroprotection in rats: role of blood flow and leukocyte adherence.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Disease Models, Animal; Flavonoids; | 1997 |
Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Disease Models, Animal; Drug The | 1997 |
New ulcerative colitis model induced by sulfhydryl blockers in rats and the effects of antiinflammatory drugs on the colitis.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Colitis, | 1997 |
Endothelial dysfunction in the perfused kidney from the streptozotocin-induced diabetic rat.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Animals; Anticoagulants; Arachidonic Acids; Biological | 1997 |
Analysis of pathogenic elements involved in gastric lesions induced by non-steroidal anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Deoxyglucose; Disease Models, Ani | 1997 |
Intracisternal injection of basic fibroblast growth factor reduces the severity of gastric mucosal lesions evoked by ethanol in rats.
Topics: Animals; Anti-Ulcer Agents; Brain; Cisterna Magna; Disease Models, Animal; Ethanol; Fibroblast Growt | 1997 |
L-arginine reverses indomethacin-induced inhibition of inflammatory fluid secretion of the feline gall bladder.
Topics: Animals; Arginine; Cats; Cholecystitis; Chronic Disease; Cyclooxygenase Inhibitors; Disease Models, | 1997 |
Combined non-steroidal therapy in experimental corneal injury.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns, Chemical; Cornea; | 1997 |
Indomethacin attenuates the renal actions of atrial natriuretic factor in dogs with chronic heart failure.
Topics: Aldosterone; Animals; Arteriovenous Fistula; Atrial Natriuretic Factor; Chronic Disease; Creatinine; | 1997 |
[A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump].
Topics: Acetates; Animals; Anti-Ulcer Agents; Disease Models, Animal; Indomethacin; Infusion Pumps, Implanta | 1997 |
Immunopharmacological studies on collagen-induced arthritis in dark Agouti (DA) rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arth | 1997 |
Modulation of adjuvant-induced arthritis by dietary arachidonic acid in essential fatty acid-deficient rats.
Topics: Animals; Arachidonic Acid; Arthritis, Experimental; Body Weight; Dietary Fats; Disease Models, Anima | 1997 |
Kinetics of fibroblasts in ulcer healing in rats: interference with indomethacin.
Topics: Acetic Acid; Actins; Animals; Apoptosis; Culture Techniques; Cyclooxygenase Inhibitors; Disease Mode | 1997 |
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity.
Topics: Animals; Cardiac Output, Low; Chronic Disease; Coronary Circulation; Cricetinae; Disease Models, Ani | 1997 |
Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Caustics; Disease Models, Anima | 1997 |
Circadian reactivity rhythm of rat gastric mucosa to restraint-cold stress and indomethacin: temporal variation in the protective effect of iloprost.
Topics: Animals; Anti-Ulcer Agents; Circadian Rhythm; Cold Temperature; Disease Models, Animal; Drug Adminis | 1997 |
Changes in vascular porosity and joint blood flow during development of collagen induced arthritis in the rat. Modulation by indomethacin and L-NAME.
Topics: Animals; Arthritis; Capillary Permeability; Collagen; Disease Models, Animal; Female; Hindlimb; Indo | 1997 |
Long-term treatment of indomethacin reduces vertebral bone mass and strength in ovariectomized rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Bod | 1997 |
Beneficial effect of ETA receptor blockade in a rat model of radiocontrast-induced nephropathy.
Topics: Acute Kidney Injury; Animals; Atrasentan; Contrast Media; Creatinine; Diatrizoate; Disease Models, A | 1997 |
Prostaglandins modulate constitutive isoform of heat shock protein (72 kD) response following trauma to the rat spinal cord.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Heat-Shock Proteins; HSP72 Heat-Shock Pr | 1997 |
Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ben | 1997 |
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
Topics: Animals; Aspirin; Biological Transport; Cyclooxygenase Inhibitors; Digestive System; Disease Models, | 1998 |
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
Topics: Animals; Aspirin; Biological Transport; Cyclooxygenase Inhibitors; Digestive System; Disease Models, | 1998 |
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
Topics: Animals; Aspirin; Biological Transport; Cyclooxygenase Inhibitors; Digestive System; Disease Models, | 1998 |
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
Topics: Animals; Aspirin; Biological Transport; Cyclooxygenase Inhibitors; Digestive System; Disease Models, | 1998 |
Limitation of activity in an acute model of arthritis: effect of drug treatment.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Chromatography, High Pre | 1997 |
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dicl | 1998 |
Differential effect of indomethacin and ketorolac on postoperative ileus in rats.
Topics: Animals; Disease Models, Animal; Indomethacin; Intestinal Obstruction; Ketorolac; Nitric Oxide; Nitr | 1998 |
Indomethacin-induced reduction in neonatal piglet mesenteric blood flow is blunted by dopexamine.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents, | 1998 |
Osteoclast-like cells in murine collagen induced arthritis.
Topics: Acid Phosphatase; Animals; Arthritis, Experimental; Bone Resorption; Cell Count; Cells, Cultured; Co | 1998 |
Mechanism of purgative effect of magnesium sulphate on mouse colon.
Topics: Animals; Anthracenes; Cathartics; Chloride Channels; Colon; Diarrhea; Disease Models, Animal; Drug I | 1997 |
Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Membrane Permeability; Cyclooxygenase Inhibit | 1998 |
Gastroprotective effect of Copaifera langsdorffii oleo-resin on experimental gastric ulcer models in rats.
Topics: Animals; Balsams; Disease Models, Animal; Ethanol; Fabaceae; Gastric Acid; Gastric Mucosa; Indometha | 1998 |
Preventive strategies in endothelin-induced renal failure.
Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, No | 1998 |
Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Disease Models, Animal; Ear Diseases; Edema; Fo | 1998 |
Lactulose and neomycin attenuate leukocyte-endothelial cell adhesion in an animal model of inflammatory bowel disease.
Topics: Animals; Anti-Bacterial Agents; Cell Adhesion; Cell Communication; Disease Models, Animal; Endotheli | 1998 |
Antithrombin reduces ischemia/reperfusion injury of rat liver by increasing the hepatic level of prostacyclin.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acid Chloromethyl Ketones; Animals; Antithrombin III; Disease Mo | 1999 |
Role of neurosympathetic pathways in the vascular response to sepsis.
Topics: Adaptation, Physiological; Animals; Cyclooxygenase Inhibitors; Denervation; Disease Models, Animal; | 1998 |
Effects of indomethacin on secretory function of synoviocytes from adjuvant arthritis rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Division; Cell Line; | 1998 |
Arterially perfused eye model of uveitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Ciliary Arteries; Clonixin; Complement C5a; | 1999 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
Functional characterization of endothelin receptors in hypertensive resistance vessels.
Topics: Animals; Antihypertensive Agents; Azepines; Blood Pressure; Cyclooxygenase Inhibitors; Disease Model | 1999 |
Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; C | 1999 |
Anti-ulcerogenic properties of endothelin receptor antagonists in the rat.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Endothelin Receptor Antagonists; Indomethacin; M | 1999 |
Prostaglandin E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram-negative sepsis.
Topics: Animals; Bacteroides fragilis; Bacteroides Infections; Dinoprostone; Disease Models, Animal; Down-Re | 1999 |
The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Epopr | 1999 |
A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inh | 1999 |
The effect of indomethacin on the cytokine cascade and body temperature following burn injury in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Surface Area; Body Temp | 1999 |
A new model of cancer cachexia: contribution of the ubiquitin-proteasome pathway.
Topics: Animals; Cachexia; Cysteine Endopeptidases; Dexamethasone; Disease Models, Animal; Glucocorticoids; | 1999 |
Evidence of involvement of guanylate cyclase in the prolongation of caeco-colonic transit time by indomethacin in mice.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Gastrointestinal Motility; Gastrointesti | 1998 |
Indomethacin suppresses the growth of colon 26, Meth-A and FM3A tumors in mice by reducing the prostaglandin E2 content and telomerase activity in tumor tissues.
Topics: Animals; Antineoplastic Agents; Cell Division; Dinoprostone; Disease Models, Animal; Indomethacin; I | 1999 |
Indomethacin induced gastropathy in CD18, intercellular adhesion molecule 1, or P-selectin deficient mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD18 Antigens; Cell Adhesion Molecules; Cyclooxyge | 1999 |
Expression of NOS II and its role in experimental small bowel ulceration in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Disease Models, Animal; DNA Primers | 1999 |
Indomethacin does not influence alveolar liquid clearance in anesthetized sheep or rats.
Topics: Adrenergic beta-Agonists; Albuterol; Anesthesia; Animals; Cyclic AMP; Cyclooxygenase Inhibitors; Din | 1999 |
Interventions to improve cardiopulmonary hemodynamics during laparoscopy in a porcine sepsis model.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Cardiovascular Agents; Disease Models, Anima | 1999 |
Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats.
Topics: Acetates; Administration, Oral; Animals; Colitis; Deferiprone; Disease Models, Animal; Gastric Mucos | 1999 |
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 1999 |
Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chloroform; Chronic Disease; Dexamethasone; Diseas | 1999 |
Prostaglandins and the induction of food sensitive enteropathy.
Topics: Animals; Antigens; CD4-Positive T-Lymphocytes; Celiac Disease; Chick Embryo; Cyclooxygenase Inhibito | 2000 |
Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cytosol; Dinoprost; Dinoprostone; Disease Models, Anima | 2000 |
Selective cyclooxygenase-2 (COX-2) inhibitors reduce anti-Mycobacterium antibodies in adjuvant arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Bacterial; Arthritis, Experimental; Bo | 2000 |
Site-specific effect of guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition in isolated lamb lungs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Inhalation; Anim | 2000 |
Antiinflammatory effects of seaprose-S on various inflammation models.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1999 |
Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase Inhibitors; Disease Models | 2000 |
Lipoxygenase-dependent mechanisms in hypertension.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; B | 2000 |
Cyclooxygenase inhibition reduces blood pressure elevation and vascular reactivity dysfunction caused by inhibition of nitric oxide synthase in rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, | 2000 |
Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids.
Topics: Animals; Cachexia; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression | 2000 |
Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine.
Topics: Animals; Anti-Ulcer Agents; Benzenesulfonates; Disease Models, Animal; Gastric Juice; Histamine H2 A | 2000 |
Uncompensated polyuria in a mouse model of Bartter's syndrome.
Topics: Animals; Bartter Syndrome; Calcium; Carrier Proteins; Disease Models, Animal; Electrolytes; Hydronep | 2000 |
Effects of hydrogen peroxide scavenger Catalase on villous microcirculation in the rat small intestine in a model of inflammatory bowel disease.
Topics: Animals; Blood Flow Velocity; Catalase; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Eval | 2000 |
The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; Chalcone; Chalco | 2000 |
Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse.
Topics: Animals; Blotting, Northern; Calcium; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2000 |
Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis.
Topics: Animals; Blotting, Western; Celecoxib; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclo | 2000 |
Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; | 2000 |
Antiulcerogenic effects of Tylophora conspicua in male rats.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gas | 2000 |
Comparison of the intestinal toxicity of celecoxib, a selective COX-2 inhibitor, and indomethacin in the experimental rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Membrane Permeability; Cyclooxygen | 2000 |
Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; | 2000 |
Renin-angiotensin system blockade improves endothelial dysfunction in hypertension.
Topics: Acetylcholine; Administration, Oral; Angiotensin Receptor Antagonists; Animals; Anti-Inflammatory Ag | 2000 |
Antiulcer effectiveness of Maytenus aquifolium spray dried extract.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Indomethacin; Male; Phytotherapy; Plant | 2000 |
Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm).
Topics: Alloxan; Animals; Antioxidants; Bronchial Spasm; Diabetes Mellitus, Experimental; Disease Models, An | 2000 |
Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats.
Topics: Animals; Asteraceae; Cyclohexanes; Disease Models, Animal; Indomethacin; Male; Methanol; Methylene C | 2000 |
Lyprinol: anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model for dysmenorrhoea.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bivalvia; Cyclooxygenase | 2000 |
In vivo assessment of villous microcirculation in the rat small intestine in indomethacin-induced inflammation: role of mast-cell stabilizer Ketotifen.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Arterioles; Blood Flow Veloc | 2000 |
Intrarenal expression and distribution of cyclooxygenase isoforms in rats with experimental heart failure.
Topics: Animals; Arteriovenous Shunt, Surgical; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibit | 2001 |
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship, | 2001 |
A new technique for the analysis of endogenous mediators released following thermal injury.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Dinoprostone; Disease Models, Ani | 2001 |
Role of altered cyclooxygenase metabolism in impaired cerebrovasodilation to nociceptin/orphanin FQ following brain injury.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blood; Blood Pressure; Brain Inj | 2000 |
Role of chemical mediators in airway hyperresponsiveness in an asthmatic model.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response | 2001 |
A novel derivative pentacyclic triterpene and omega 3 fatty acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Carbohydrate Metabolism; Collagen; Dise | 2001 |
Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apopt | 2001 |
Inhibition of hypoxic pulmonary vasoconstriction by carbon monoxide in dogs.
Topics: Administration, Inhalation; Animals; Carbon Monoxide; Cyclooxygenase Inhibitors; Disease Models, Ani | 2001 |
Cyclooxygenase-2 expression in the hippocampus of genetically epilepsy susceptible El mice was increased after seizure.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2001 |
Ocular blood flow and retinal metabolism in abyssinian cats with hereditary retinal degeneration.
Topics: Animals; Blood Flow Velocity; Blood Glucose; Cardiovascular Agents; Cats; Choroid; Disease Models, A | 2001 |
Evidence for bradykinin mediation of carrageenin-induced inflammatory pain: a study using kininogen-deficient Brown Norway Katholiek rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Disease Models, Animal; E | 2001 |
Haloperidol-stomach lesions attenuation by pentadecapeptide BPC 157, omeprazole, bromocriptine, but not atropine, lansoprazole, pantoprazole, ranitidine, cimetidine and misoprostol in mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Atropine; Benzimidazoles; Bromo | 2001 |
Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adjuvants, Immunologic; Administration, Cutaneous; Animals; Anti-I | 2001 |
Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2001 |
Progressive lung and cardiac changes associated with pulmonary hypertension in the fetal rat.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Female; Fetal Heart; Hypertension, Pulmonary; | 2001 |
Delayed healing of gastric ulcers in adjuvant arthritis rats: role of acid secretion and basic fibroblast growth factor.
Topics: Animals; Arthritis, Rheumatoid; Blotting, Western; Disease Models, Animal; Fibroblast Growth Factors | 2001 |
Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, M | 2001 |
Effects of steroidal and non-steroidal antiphlogistic drugs on eicosanoid synthesis in irritated skin: studies with the isolated perfused bovine udder.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2001 |
Role of intercellular adhesion molecule 1 in indomethacin-induced ileitis.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Endothelium; Ileitis; Indomethacin; Interce | 2001 |
Synergistic effect of indomethacin and bleomycin on tumor growth produced by activating antitumor immunity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cell Survival; Disease Models, A | 2001 |
Effects of some nonsteroidal anti-inflammatory drugs on articular cartilage of rats in an experimental model of osteoarthritis.
Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Diclofena | 2001 |
Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Disease Models, An | 2001 |
Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Mis | 2001 |
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Chronic Disease; Cycloox | 2001 |
Compensated heart failure predisposes to outer medullary tubular injury: studies in rats.
Topics: Acute Kidney Injury; Animals; Cardiomegaly; Cardiovascular Agents; Disease Models, Animal; Enzyme In | 2001 |
Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer.
Topics: Animals; Breast Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2001 |
Impaired relaxation to acetylcholine in 2K-1C hypertensive rat aortas involves changes in membrane hyperpolarization instead of an abnormal contribution of endothelial factors.
Topics: Acetylcholine; Animals; Aorta; Biological Factors; Cyclic GMP; Disease Models, Animal; Endothelium, | 2000 |
Potentiated endothelium-derived hyperpolarizing factor-mediated dilations in cerebral arteries following mild head injury.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biological Factors; Brain Injuries; Charybdot | 2001 |
Glutamine transporter in crypts compensates for loss of villus absorption in bovine cryptosporidiosis.
Topics: Amino Acid Transport Systems; Amino Acid Transport Systems, Basic; Animals; Blotting, Western; Carri | 2001 |
[Experimental model of infection of Helicobacter pylori in the mouse. A study of gastric damage caused by indomethacin].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Gastric Mucosa; Helicobact | 2001 |
Up-regulation of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide by aspirin but not indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Disease Models, Animal; Gastri | 2001 |
Lipid peroxidation and platelet activation in murine atherosclerosis.
Topics: Animals; Antioxidants; Aorta; Arteriosclerosis; Cyclooxygenase Inhibitors; Diet, Atherogenic; Dietar | 2001 |
Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model.
Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age | 2001 |
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2001 |
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2001 |
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2001 |
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2001 |
In vitro indomethacin administration upregulates interleukin-12 production and polarizes the immune response towards a Th1 type in susceptible BALB/c mice infected with Leishmania mexicana.
Topics: Animals; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Enzyme- | 2001 |
Role of cyclopentenone prostaglandins in rat carrageenin pleurisy.
Topics: Active Transport, Cell Nucleus; Animals; Carrageenan; Cyclooxygenase Inhibitors; Disease Models, Ani | 2001 |
Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
Topics: Acetic Acid; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; B | 2001 |
Effects of diacerein on indomethacin-induced gastric ulceration.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dinoprostone; D | 2001 |
Antiulcerogenic effect of Hippophae rhamnoides L.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Famotidine; Fruit; Indomethacin; Male; Misoprost | 2001 |
Adaptive cytoprotection against acetic acid induced colonic injury in rats.
Topics: Acetic Acid; Animals; Colon; Colonic Diseases; Culture Techniques; Cytoprotection; Disease Models, A | 2001 |
Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs.
Topics: Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Chronic Disease; Cysteamine; Disease Models, | 2001 |
Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat.
Topics: Acute Disease; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Cannabinoid Rece | 2002 |
Establishment of an animal model of chronic atrophic gastritis and a study on the factors inducing atrophy.
Topics: Ammonia; Animals; Atrophy; Deoxycholic Acid; Disease Models, Animal; Ethanol; Gastric Mucosa; Gastri | 2001 |
[Cytokines in experimental cancer cachexia].
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Cachex | 2001 |
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen | 2001 |
Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis.
Topics: Animals; Arthritis; Body Weight; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitor | 2002 |
High NaCl intake decreases both flow-induced dilation and pressure-induced myogenic tone in resistance arteries from normotensive rats: involvement of cyclooxygenase-2.
Topics: Animals; Arginine; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2001 |
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD4-Positive T-Lymphocytes; Cell Division; Colon; | 2002 |
Pharmacologic and autoradiographic evidence for an up-regulation of kinin B(2) receptors in the spinal cord of spontaneously hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoradiography; Binding Sites; Blood Pressure; Br | 2002 |
Gastric ulcerogenic responses following barrier disruption in knockout mice lacking prostaglandin EP1 receptors.
Topics: Animals; Bridged Bicyclo Compounds; Caproates; Cytoprotection; Dinoprostone; Disease Models, Animal; | 2002 |
Rat renal function four days after bile-duct ligation: effects of indomethacin and vasoactive agents.
Topics: Animals; Bile Ducts; Cyclooxygenase Inhibitors; Disease Models, Animal; Glomerular Filtration Rate; | 2002 |
[Experimental ulcer].
Topics: Animals; Caffeine; Cats; Cattle; Chickens; Disease Models, Animal; Dogs; Ducks; Guinea Pigs; Haplorh | 1975 |
Measurement of prostaglandin E2 in an inflammatory exudate: effects of nonsteroidal anti-inflammatory agents.
Topics: Abscess; Animals; Anti-Inflammatory Agents; Carrageenan; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxyli | 1977 |
Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers.
Topics: Administration, Oral; Animals; Aspirin; Carbachol; Depression, Chemical; Disease Models, Animal; Duo | 1977 |
Inhibitors of gastric lesions in the rat.
Topics: Animals; Aspirin; Disease Models, Animal; Female; Glutamine; Histamine Antagonists; Indomethacin; Li | 1978 |
Comparative studies on starvation - and indomethacin - induced ulcerations in albino rats.
Topics: Animals; Disease Models, Animal; Female; Gastric Juice; Hydrogen-Ion Concentration; Indomethacin; Ma | 1978 |
Pharmacology of Schultz-Dale reaction in canine lung strip in vitro: possible model for allergic asthma.
Topics: Anaphylaxis; Animals; Asthma; Autacoids; Disease Models, Animal; Dogs; Female; Histamine H1 Antagoni | 1979 |
Single and multiple drug therapy in autologous immune complex nephritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azathioprine; Basement Membrane; Compleme | 1976 |
Standardization of an experimental immune uveitis in the rabbit for topical testing of drugs.
Topics: Administration, Topical; Animals; Antibodies; Aqueous Humor; Arthus Reaction; Dexamethasone; Disease | 1976 |
Potassium permanganate induced calcergy: a model to study the effects of drugs on hydroxyapatite crystal deposition.
Topics: Animals; Calcinosis; Clodronic Acid; Dexamethasone; Disease Models, Animal; Etidronic Acid; Hydroxya | 1979 |
Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation.
Topics: Animals; Calcium Phosphates; Cyclic AMP; Diphosphates; Disease Models, Animal; Indomethacin; Inflamm | 1975 |
Actinomycin D peritonitis in rats: a tool for the study of early events in inflammation.
Topics: Animals; Cell Movement; Cyclic AMP; Cyclic GMP; Dactinomycin; Disease Models, Animal; Female; Flupre | 1976 |
[2 models of indomethacin-induced arterial hypertension in rats in chronic experiments].
Topics: Aldosterone; Angiotensins; Animals; Cyclic AMP; Disease Models, Animal; Hypertension; Indomethacin; | 1977 |
Studies on the experimental therapy of iridocyclitis.
Topics: Animals; Anti-Inflammatory Agents; Aqueous Humor; Disease Models, Animal; Female; Hydrocortisone; Ib | 1979 |
Effect of indomethacin on intestinal water transport in salmonella-infected rhesus monkeys.
Topics: Animals; Colon; Disease Models, Animal; Haplorhini; Ileum; Indomethacin; Intestinal Absorption; Inte | 1977 |
Hypovolemic models of acute tubular necrosis in the rat kidney.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Indomethacin; Kidney Tubular Necrosis, Acute; | 1977 |
Inhibition by aspirin of gastrointestinal toxicity induced by indomethacin in polyarthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Disease Models, Animal; Dose-Response Relation | 1979 |
[The role of lysosomal enzymes in adjuvant-induced uveitis in rabbits (author's transl)].
Topics: Acid Phosphatase; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease | 1979 |
Modification of experimental renal hypertension in the rat by indomethacin and hydralazine.
Topics: Animals; Disease Models, Animal; Female; Hydralazine; Hypertension, Renal; Indomethacin; Potassium; | 1978 |
Distention ulcer as a model for testing of drugs for ulcerogenic side effects.
Topics: Animals; Aspirin; Disease Models, Animal; Hydrochloric Acid; Indomethacin; Male; Rats; Stomach; Stom | 1978 |
Indomethacin and lysine acetylsalicylate in rats with autologous nephrotoxic serum nephritis. Biochemical and morphological studies.
Topics: Animals; Aspirin; Basement Membrane; Disease Models, Animal; Female; Glomerulonephritis; Immune Sera | 1978 |
The effects of aspirin and indomethacin on the ocular response to circulating bacterial endotoxin in the rabbit.
Topics: Animals; Aspirin; Disease Models, Animal; Dogs; Endotoxins; Escherichia coli; Eye; Female; Indometha | 1976 |
Effects of indomethacin and nicotinic acid on E. coli endotoxin shock in anesthetized dogs.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Dogs; Endotoxins; Escherichia coli; | 1976 |
A primate model for the study of human fever.
Topics: Animals; Body Temperature; Circadian Rhythm; Disease Models, Animal; Dose-Response Relationship, Dru | 1975 |
The effects of indomethacin treatment on experimental nephritis in rats.
Topics: Animals; Disease Models, Animal; Indomethacin; Nephritis; Rats | 1975 |
Prostaglandins and the hemodynamic course of endotoxin shock.
Topics: Animals; Aspirin; Blood Pressure; Cardiac Output; Disease Models, Animal; Haplorhini; Hemodynamics; | 1976 |
Prostaglandins and the renin-angiotensin system in canine endotoxemia.
Topics: Angiotensin II; Animals; Disease Models, Animal; Dogs; Female; Hemodynamics; Indomethacin; Kidney; M | 1977 |
Exaggerated prostaglandin biosynthesis and its influence on renal resistance in the isolated hydronephrotic rabbit kidney.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Arachidonic Acids; Bradykinin; Disease Models, Anim | 1977 |
Effects of antiinflammatory agents on the acute response of immune synovitis in rabbits.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Colchicine; Disease Models, Animal; Dose-Response Relati | 1977 |
Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Carrageenan; Chr | 1977 |
Activity of anti-inflammatory drugs on an experimental model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cartilage, Articular; Catalase; Disease Models, Animal; | 1976 |
Symposium on specific therapy for rheumatoid arthritis: specific therapy in new conventional animal models.
Topics: Animals; Arthritis, Rheumatoid; Clotrimazole; Dexamethasone; Disease Models, Animal; Gold; Indometha | 1976 |
Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Edema; Female; Freund's Adjuvant; Hyp | 1976 |
Pertussis vaccine pleurisy: a model of delayed hypersensitivity.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Freund's Adjuvant; Hypersensitivity, | 1976 |
Pathway to adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Disease Models, Animal; Foot; Indomethacin; Inflammatio | 1976 |
Quantitative studies of the pathway to acute carrageenan inflammation.
Topics: Acute Disease; Animals; Carrageenan; Chemotaxis; Cyproheptadine; Disease Models, Animal; Edema; Indo | 1976 |
Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Cortisone; Cyclohexanecarboxylic Acids; Disease Model | 1976 |
Effect of indomethacin on fracture healing in rats.
Topics: Animals; Bony Callus; Disease Models, Animal; Elasticity; Femoral Fractures; Indomethacin; Male; Rad | 1976 |
[Effects of various drugs on experimental ulcer in the rat].
Topics: Animals; Disease Models, Animal; Female; Indomethacin; Peptides; Pyridines; Rats; Stomach Ulcer | 1976 |
Endocrine-type antihypertensive function of renomedullary interstitial cells.
Topics: Angiotensin II; Animals; Blood Pressure; Cells, Cultured; Connective Tissue; Connective Tissue Cells | 1975 |
A sensitive method for the comparative bioassay of nonsteroidal anti-inflammatory compounds in adjuvant-induced primary inflammation in the rat.
Topics: Aminopyrine; Analysis of Variance; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin | 1975 |
Hypercalcemia and tumor-prostaglandins: the VX2 carcinoma model in the rabbit.
Topics: Animals; Biological Assay; Bone Resorption; Carcinoma; Disease Models, Animal; Femoral Vein; Hyperca | 1975 |
Genetic hypertension in rats is accompanied by a defect in renal prostaglandin catabolism.
Topics: Animals; Disease Models, Animal; Drug Synergism; Hydroxyprostaglandin Dehydrogenases; Hypertension; | 1976 |
Experimental inflammation induced by naturally occurring microcrystalline calcium salts.
Topics: Animals; Anti-Inflammatory Agents; Calcium; Calcium Phosphates; Carrageenan; Colchicine; Copper; Dis | 1976 |
Influence of cloprostenol in the experimentally induced ulcer in rats.
Topics: Animals; Cloprostenol; Disease Models, Animal; Drug Evaluation, Preclinical; Indomethacin; Male; Rat | 1992 |
Modulation of immune responses by cyclo-oxygenase inhibitors during intraocular inflammation.
Topics: Animals; Antigens; Arrestin; Autoantibodies; Dinoprostone; Disease Models, Animal; Eye Proteins; Fem | 1992 |
Experimental models of acute and chronic sialoadenitis in the guinea pig.
Topics: Acute Disease; Animals; Chronic Disease; Cyclophosphamide; Disease Models, Animal; Guinea Pigs; Hype | 1992 |
Studies of gut mucosal protein synthesis in a non-steroidal anti-inflammatory drug (NSAID) model of inflammatory bowel disease.
Topics: Animals; Disease Models, Animal; DNA; Duodenum; Ileum; Indomethacin; Inflammatory Bowel Diseases; In | 1992 |
Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs.
Topics: Adenine Nucleotides; Animals; Ascorbic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstrictio | 1992 |
A sensitive and relevant model for evaluating anti-inflammatory activity-papaya latex-induced rat paw inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Mod | 1992 |
Immunologic abnormalities in canine juvenile polyarteritis syndrome: a naturally occurring animal model of Kawasaki disease.
Topics: Animals; Aorta; Arthritis, Juvenile; Autoantibodies; Disease Models, Animal; Dog Diseases; Dogs; Imm | 1992 |
Hemodynamic effects following intraperitoneal infusion of pancreatic ascites fluid.
Topics: Acute Disease; Animals; Ascitic Fluid; Disease Models, Animal; Extravascular Lung Water; Hemodynamic | 1992 |
Mechanism and prevention of chronic colonic inflammation with trinitrobenzene sulfonic acid in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chronic Disease; Colitis; Colon; Cyclosporine; Diseas | 1992 |
Qualitative defects in natural killer cell function in ia osteopetrotic rats.
Topics: Animals; Cytotoxicity, Immunologic; Disease Models, Animal; Indomethacin; Interleukin-2; Killer Cell | 1992 |
Indomethacin-induced enteropathy: effect of the drug regimen on intestinal permeability in rats.
Topics: Administration, Oral; Animals; Chromatography, Gas; Disease Models, Animal; Indomethacin; Inflammato | 1992 |
Inhibitory effect of tetrandrine on lens proteins-induced ocular inflammation in rabbits.
Topics: Alkaloids; Animals; Anterior Chamber; Anti-Inflammatory Agents, Non-Steroidal; Benzylisoquinolines; | 1992 |
Therapeutic effect of Ga-Al-As diode laser irradiation on experimentally induced inflammation in rats.
Topics: Aluminum; Animals; Arsenic; Blood Proteins; Body Water; Capillary Permeability; Carrageenan; Dermati | 1992 |
Autoimmune kidney disease in MRL/lpr mice inhibited by OK-432; II. Effect of indomethacin.
Topics: Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Autoimmune Diseases; Dinoprostone; Disea | 1992 |
Effects of renin-angiotensin system blockade in guinea pigs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Bradykinin; C | 1992 |
In-vivo administration of interleukin 1 both enhances and suppresses contact sensitivity in the mouse.
Topics: Animals; Dermatitis, Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, Externa | 1992 |
Group B streptococcal sepsis in piglets: effect of combined pentoxifylline and indomethacin pretreatment.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Indometh | 1992 |
Thromboxane mediates glomerular haemodynamics in a model of chronic glomerular disease.
Topics: Animals; Dietary Proteins; Disease Models, Animal; Eicosanoids; Glomerular Filtration Rate; Glomerul | 1992 |
Inhibitory effect of NZ-107 on anaphylactic bronchoconstriction in guinea pigs and rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Anaphylaxis; Anim | 1992 |
Osteolytic activity of Walker carcinosarcoma 256 is due to parathyroid hormone-related protein (PTHrP).
Topics: Adenylyl Cyclases; Animals; Carcinoma 256, Walker; Culture Media; Cyclic AMP; Dexamethasone; Disease | 1991 |
Tumour necrosis factor production in a rat airpouch model of inflammation: role of eicosanoids.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Indomethacin; Inflammation | 1991 |
Treatment of S antigen uveoretinitis with lipoxygenase and cyclo-oxygenase inhibitors.
Topics: Animals; Anthropometry; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Arrestin; Dinoprostone; D | 1991 |
Enhancement of coxsackievirus B4 virulence by indomethacin.
Topics: Animals; Antibodies, Viral; Coxsackievirus Infections; Disease Models, Animal; Enterovirus B, Human; | 1990 |
Downward regulation of neutrophil infiltration by endogenous histamine without affecting vascular permeability responses in air-pouch-type carrageenin inflammation in rats.
Topics: Anaphylaxis; Animals; Capillary Permeability; Carrageenan; Disease Models, Animal; Histamine; Histam | 1991 |
[Effect of drugs inhibiting prostaglandin activity on the appearance of leukocytes in the tears after experimental injury to the corneal epithelium].
Topics: Animals; Chemotaxis, Leukocyte; Corneal Injuries; Disease Models, Animal; Epithelium; Female; Ibupro | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationshi | 1991 |
Role of arachidonic acid metabolites in the pathogenesis of acute lung injury.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate 5-Lipoxygenase; | 1991 |
Histochemical analysis of experimental granulomatous uveitis.
Topics: Acid Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Crystallins; Disease Models, Ani | 1991 |
Role of acid milieu in the gastroprotective and ulcer-healing activity of sucralfate.
Topics: Animals; Chronic Disease; Combined Modality Therapy; Disease Models, Animal; Drug Therapy, Combinati | 1991 |
Modulation of splanchnic vascular sensitivity to angiotensin II.
Topics: Angiotensin II; Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Epoprostenol; Hypertensi | 1991 |
The effects of sucralfate and luminal stasis on recovery of the chambered rat gastric mucosa from taurocholate-induced damage.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Ga | 1991 |
Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil.
Topics: Animals; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Edema; Gerbillinae; Indomethacin; | 1991 |
[The effect of interleukin-1 on ocular inflammation in rabbit ocular tissue].
Topics: Animals; Aqueous Humor; Dinoprostone; Disease Models, Animal; Endophthalmitis; Eye Proteins; Indomet | 1991 |
Characteristics and modulation of dithranol (anthralin)-induced skin irritation in the mouse ear model.
Topics: Administration, Topical; Adrenal Cortex Hormones; Animals; Anthralin; Anti-Inflammatory Agents, Non- | 1991 |
Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat.
Topics: Acetates; Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; | 1990 |
Experimental non-steroidal anti-inflammatory drug-induced enteropathy in the rat: similarities to inflammatory bowel disease and effect of thromboxane synthetase inhibitors.
Topics: Animals; Cell Membrane Permeability; Chromium Radioisotopes; Disease Models, Animal; Edetic Acid; Il | 1990 |
Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits.
Topics: Animals; Brain Edema; Dinoprostone; Disease Models, Animal; Indomethacin; Meningitis, Pneumococcal; | 1991 |
The role of capsaicin-sensitive afferent nerves in protective effect of capsaicin against absolute ethanol-induced gastric lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Disease Models, Animal; Ethanol; Gastri | 1991 |
[Prostaglandin levels in the lung tissue of guinea pigs with tuberculosis treated with antitubercular drugs and indomethacin].
Topics: Animals; Antitubercular Agents; Dinoprost; Disease Models, Animal; Drug Therapy, Combination; Guinea | 1990 |
Different resorption modes on living and devitalized bones by isolated osteoclasts in vitro. The effects of TIMP, E-64, and TGF-alpha.
Topics: Animals; Bone Resorption; Cysteine Proteinase Inhibitors; Disease Models, Animal; Female; Glycoprote | 1990 |
Ultraviolet radiation suppresses mouse-ear edema induced by topical application of arachidonic acid.
Topics: Administration, Topical; Animals; Arachidonic Acids; Benzoquinones; Cell Count; Disease Models, Anim | 1990 |
Interleukin-6 serum levels correlate with footpad swelling in adjuvant-induced arthritic Lewis rats treated with cyclosporin A or indomethacin.
Topics: Animals; Arthritis; Arthritis, Experimental; Cyclosporins; Disease Models, Animal; Edema; Foot; Indo | 1990 |
Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis.
Topics: Animals; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Immune Tolerance; In | 1990 |
Common bile ligation in the rabbit: an appropriate model for investigating the relationship of endogenous gallbladder prostanoid synthesis with evolving acute inflammation.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cholecystitis; Common Bile Duct; Dinoprostone; Disease Models | 1990 |
Short-term therapy of atherosclerosis with low dose indomethacin: an experimental study.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Body Weight; Cholesterol; Coronary Artery Disease; Diet, Athe | 1990 |
Responses of equine trachealis and lung parenchyma to methacholine, histamine, serotonin, prostanoids, and leukotrienes in vitro.
Topics: Animals; Asthma; Atropine; Disease Models, Animal; Histamine; Horses; In Vitro Techniques; Indometha | 1990 |
Effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis of mice.
Topics: Animals; Antibodies; Arthritis; Arthritis, Experimental; Collagen; Cyclophosphamide; Cyclosporins; D | 1990 |
Effect of low dose recombinant interleukin 2 plus indomethacin on mortality after sepsis in a murine burn model.
Topics: Animals; Bacterial Infections; Burns; Disease Models, Animal; Drug Therapy, Combination; Indomethaci | 1990 |
Inhibition of tumor growth and metastasis by chronic intravenous infusion of prostaglandin E1.
Topics: Alprostadil; Animals; Disease Models, Animal; Indomethacin; Infusions, Intravenous; Lung Neoplasms; | 1990 |
Gastric antral and fundic mucosal protein, DNA and RNA changes in different experimental ulcer models.
Topics: Animals; Disease Models, Animal; DNA; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Proteins | 1985 |
Prevention by prostaglandins of caerulein-induced pancreatitis in rats.
Topics: 16,16-Dimethylprostaglandin E2; Amylases; Animals; Carbachol; Ceruletide; Cholecystokinin; Dinoprost | 1989 |
Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Hypertension, Pulmonary; Indome | 1989 |
Effect of prostaglandin E in multiple experimental models. VI. Effect on T-cell subsets.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Burns; Disease Models, Animal; Indomethacin; Leukocyte Coun | 1989 |
Profile and sites of eicosanoid release in experimental necrotizing enterocolitis.
Topics: Animals; Biological Assay; Disease Models, Animal; Enterocolitis, Pseudomembranous; In Vitro Techniq | 1989 |
The histopathology of corneal neovascularization. Inhibitor effects.
Topics: Animals; Chemotaxis, Leukocyte; Cornea; Corneal Injuries; Disease Models, Animal; Electrocoagulation | 1985 |
Indomethacin antagonizes the ethanol-induced suppression of breathing activity but not the suppression of brain activity in the near-term fetal sheep.
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Ethanol; Female; Fetus; Indomethacin | 1989 |
The therapeutic potential of interleukin-1 beta in the treatment of chemotherapy- or radiation-induced myelosuppression and in tumor therapy.
Topics: Animals; Antineoplastic Agents; Bacterial Infections; Bone Marrow; Combined Modality Therapy; Diseas | 1989 |
Experimental renal papillary necrosis in the Syrian hamster.
Topics: Acetaminophen; Animals; Cricetinae; Disease Models, Animal; Ethylamines; Indomethacin; Kidney Medull | 1989 |
A possible role for PAF in allergen-induced late responses: modification by a selective antagonist.
Topics: Aerosols; Allergens; Animals; Antigens, Helminth; Ascaris; Asthma; Azepines; Chlorpheniramine; Chrom | 1989 |
Studies on carrageenin air pouch inflammation in the rat.
Topics: Animals; Carrageenan; Dermatitis, Contact; Disease Models, Animal; Exudates and Transudates; Indomet | 1989 |
The differentiation of NSAIDs and prostaglandin action using a mechanical visceral pain model in the rat.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Dose-Re | 1989 |
Effect of indomethacin on swelling, lymphocyte influx, and cartilage proteoglycan depletion in experimental arthritis.
Topics: Animals; Antigens; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; | 1989 |
Argon laser-induced ocular hypertension: animal model of ocular inflammation.
Topics: Animals; Aqueous Humor; Argon; Disease Models, Animal; Endophthalmitis; Female; Flurbiprofen; Gangli | 1989 |
Corneal endothelial wound closure in vitro. Effects of EGF and/or indomethacin.
Topics: Animals; Cell Count; Cell Division; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothel | 1989 |
Healing process of duodenal ulcers induced by indomethacin plus histamine in rats.
Topics: Animals; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Duodenum; Gastric Acid; Histamine; Hydr | 1989 |
Arachidonic acid-induced pleurisy (ARIP): an in vivo model for testing 5-lipoxygenase inhibition.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; A | 1987 |
Effect of indomethacin in the late phase of coxsackievirus myocarditis in a murine model.
Topics: Animals; Atrial Natriuretic Factor; Chronic Disease; Coxsackievirus Infections; Disease Models, Anim | 1988 |
Postischemic generation of superoxide anion by newborn pig brain.
Topics: Animals; Animals, Newborn; Blood Pressure; Brain; Disease Models, Animal; Female; Indomethacin; Isch | 1988 |
Increased serum immunoreactive prolyl hydroxylase in rats with carrageenan-induced granuloma and adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Benzopyrans; C | 1988 |
The effect of anti-inflammatory and rheumatoid disease modifying drugs on prolonged immune and non-immune inflammation in the six-day air pouch of rats.
Topics: Animals; Anti-Inflammatory Agents; Bordetella pertussis; Carrageenan; Dexamethasone; Disease Models, | 1986 |
Effects of prostacyclin, indomethacin, and thiothromboxane A2 on histamine-induced coronary spasm in atherosclerotic miniature swine.
Topics: Animals; Arteriosclerosis; Coronary Vasospasm; Disease Models, Animal; Epoprostenol; Histamine; Indo | 1985 |
Changes of cAMP and cGMP levels of rat antral and fundic gastric mucosa in different ulcer models.
Topics: Animals; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Female; Gastric Fundus; Gastric Mucosa; Ind | 1987 |
Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.
Topics: Alprostadil; Animals; Blood Pressure; Catechols; Chromones; Diethylcarbamazine; Disease Models, Anim | 1986 |
[Anti-cancer treatment with prostaglandin synthetase inhibitor in animal models].
Topics: Animals; Cell Division; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Indomethacin; Mic | 1986 |
Prostaglandin synthetase inhibition in group B streptococcal shock: hematologic and hemodynamic effects.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bicarbonates; Blood Gas Analysis; Blood Platelets; Blood Pres | 1986 |
Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs.
Topics: Animals; Body Water; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Ethchlorvynol; Hypoxia | 1986 |
Parathyroidectomy increases peripheral vascular responsiveness to exogenous noradrenaline in the uraemic rat.
Topics: Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Indomethacin; Male; Norepinephrine | 1987 |
Nonsteroidal anti-inflammatory drugs correct the bactericidal defect of polymorphonuclear leukocytes in a guinea pig model of thermal injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Bactericidal A | 1988 |
Group B streptococcal (GBSS) newborn septic shock model: the role of prostaglandins.
Topics: Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, | 1988 |
Systemic and regional hemodynamic effects of cyclo-oxygenase and thromboxane synthetase inhibition in normal and hyperdynamic endotoxemic rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Endotoxins | 1988 |
[Effects of an anti-inflammatory agent of benzamide structure, dexamethasone and indomethacin on experimental cerebral edema induced by phospholipase 2 in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Benzamides; Brain Edema; Copper | 1988 |
Indomethacin-induced gastric antral ulcers in hamsters.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal | 1988 |
Flushing and haemodynamic responses to vasopressin peptides in the rhesus monkey.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Deamino Arginine Vasopressin; Disease Models, Animal; | 1988 |
Lipid peroxidation, free radicals and experimental inflammation.
Topics: Animals; Diclofenac; Disease Models, Animal; Edema; Free Radicals; Indomethacin; Inflammation; Lipid | 1988 |
Induction, prevention and mechanisms of contrast media-induced acute renal failure.
Topics: Acute Kidney Injury; Animals; Desoxycorticosterone; Diet, Sodium-Restricted; Disease Models, Animal; | 1988 |
Effects of chronic endotoxaemia on oxygen consumption at different ambient temperatures in the unanaesthetised rat.
Topics: Animals; Body Temperature Regulation; Body Weight; Chronic Disease; Consciousness; Disease Models, A | 1988 |
Serum and renal tissue concentrations of cefotaxime in urinary tract obstruction in rabbits.
Topics: Animals; Cefotaxime; Disease Models, Animal; Indomethacin; Kidney; Male; Rabbits; Ureteral Obstructi | 1988 |
Suppression of interleukin 2 production in an animal model of thermal injury is related to prostaglandin synthesis.
Topics: Animals; Burns; Disease Models, Animal; Flurbiprofen; Indomethacin; Interleukin-2; Lymphocyte Activa | 1987 |
The comparison of myocardial dysfunction in three forms of experimental septic shock.
Topics: Animals; Disease Models, Animal; Escherichia coli Infections; Haemophilus Infections; Haemophilus in | 1986 |
The effects of indomethacin on edema and gas exchange in canine acid aspiration.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Blood Pressure; Cardiac Output; Disease Models, A | 1987 |
Milk protection against experimental ulcerogenesis in rats.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Cholestyramine Resin; Disease Models, Animal; Gast | 1987 |
The use of the murine chronic graft vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery.
Topics: Animals; Cyclophosphamide; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Graft vs Ho | 1987 |
Drug effects on a novel model of connective tissue breakdown.
Topics: Animals; Arthritis, Rheumatoid; Cartilage; Connective Tissue; Cyclophosphamide; Disease Models, Anim | 1987 |
Mouse paw edema. A new model for inflammation?
Topics: Animals; Carrageenan; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Edema | 1987 |
Renal hemodynamic effects of therapeutic plasma levels of sulindac sulfide during hemorrhage.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dogs; Glome | 1986 |
An automated microcomputer-based system for determining canine paw pressure quantitatively in the dog synovitis model.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dogs; Female; Foot; Ibuprofen; Indomethac | 1986 |
Augmentation of cysteamine and mepirizole-induced lesions in the rat duodenum and stomach by histamine or indomethacin.
Topics: Animals; Cysteamine; Disease Models, Animal; Drug Synergism; Duodenal Ulcer; Epirizole; Histamine; I | 1986 |
Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Ge | 1985 |
Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Endotoxins; Escherichia co | 1985 |
Histamine-induced spasm not significantly modulated by prostanoids in a swine model of coronary artery spasm.
Topics: Animals; Arteriosclerosis; Body Weight; Cholesterol; Coronary Vasospasm; Disease Models, Animal; Epo | 1985 |
Immunoregulation in disseminated murine histoplasmosis: disturbances in the production of interleukins 1 and 2.
Topics: Animals; Catalase; Disease Models, Animal; Histoplasmosis; Immunosorbent Techniques; Indomethacin; I | 1985 |
Leukotriene inhibitors attenuate rat lung injury induced by hydrogen peroxide.
Topics: Animals; Biological Assay; Catalase; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhib | 1985 |
Increased metabolism of arachidonic acid in an immune model of colitis in guinea-pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic | 1985 |
Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia.
Topics: Anesthesia, General; Animals; Blood Pressure; Disease Models, Animal; Endotoxins; Female; Hemodynami | 1986 |
Acute pulmonary hypertension, leucopenia and hypoxia in early haemodialysis.
Topics: Animals; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Hypoxia; Indomethacin; Leu | 1985 |
Indomethacin, (-)-terbutaline (beta 2 agonist), and (+)-terbutaline in acute inflammation induced by repeated ischemia in hamster cheek pouch.
Topics: Animals; Capillary Permeability; Cricetinae; Disease Models, Animal; Female; Indomethacin; Inflammat | 1985 |
Metastasis in the androgen-insensitive Nb rat prostatic carcinoma system.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cortisone; Disease Models, Animal; Drug Therapy, Com | 1985 |
2-(2,4-dichlorophenoxy) phenylacetic acid (fenclofenac): one of a novel series of anti-inflammatory compounds with low ulcerogenic potential.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemical Phenomena; Chemistry; Disease Mod | 1974 |
Correlations between pathological changes in the hind paws of rats with adjuvant arthritis and their response to anti-inflammatory and analgesic drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Body Temperature; Bod | 1973 |
The prophylactic and therapeutic effects of gold sodium thiomalate against adjuvant-induced polyarthritis in rats.
Topics: Adjuvants, Immunologic; Animals; Arthritis; Aspirin; Blood Sedimentation; Body Weight; Disease Model | 1973 |
[Efficacy of different antiphlogistic agents with respect to carrageenan-inflammation, compared with other models of inflammation].
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; D | 1971 |
Pharmacological studies on active bronchial anaphylaxis in the rat.
Topics: Aluminum Hydroxide; Anaphylaxis; Animals; Atropine; Bordetella pertussis; Bronchial Spasm; Cromolyn | 1974 |
A modification of rat adjuvant arthritis for testing antirheumatic drugs.
Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthr | 1972 |
BSA-induced allergic arthritis and formal-induced non-allergic arthritis in rabbits. 3. Anti-inflammatory intraarticular action of indometacin in BSA-induced allergic arthritis in rabbits.
Topics: Animals; Arthritis; Disease Models, Animal; Freund's Adjuvant; Hypersensitivity; Indomethacin; Injec | 1974 |
Alterations in platelet aggregation associated with adjuvant arthritis in rats.
Topics: Adenosine Diphosphate; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin | 1974 |
Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Body Fluids; Body Weight; Cholera; | 1972 |
Studies on the mode of action of non-steroid anti-inflammatory drugs.
Topics: Animals; Aspirin; Cell Movement; Disease Models, Animal; Indomethacin; Inflammation; Leukocytes; Mef | 1972 |
Inflammatory response in dogs given intraarticular injection of Mycobacterium butyricum-mineral oil adjuvant.
Topics: Animals; Arthritis; Arthritis, Rheumatoid; Blood Sedimentation; Disease Models, Animal; Dogs; Female | 1973 |
[Pharmacology of antiphlogistically active imidazoles].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Imidazoles; Indomethac | 1973 |
Prevention of restraint and indomethacin-induced gastric ulceration by bile duct or pylorus ligation in rats.
Topics: Animals; Bile Acids and Salts; Bile Ducts; Disease Models, Animal; Female; Indomethacin; Ligation; M | 1974 |
[Effect of indocide on the course of experimental glomerulonephritis].
Topics: Animals; Autoimmune Diseases; Blood Pressure; Blood Proteins; Complement Fixation Tests; Disease Mod | 1972 |
[Experimental study on drugs for the treatment of myocardial infarction].
Topics: Angiography; Animals; Benzyl Compounds; Body Weight; Carboxylic Acids; Dipyridamole; Disease Models, | 1972 |
Adjuvant-induced arthritis in rats. II. Drug effects on physiologic, biochemical and immunologic parameters.
Topics: Animals; Anti-Inflammatory Agents; Antibodies; Arthritis; Aspirin; Body Weight; Cyclophosphamide; Di | 1971 |
[A comparative study on various antiphlogistics].
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Asbestos; Dextrans; Disease Models, Animal; Dr | 1971 |
A model for rat paw edema. II. Analyses on the effect of the antagonists.
Topics: Amino Alcohols; Animals; Anti-Inflammatory Agents; Bradykinin; Bromelains; Carbamates; Carrageenan; | 1970 |
Comparative toxicity studies on glucuronide-forming compounds in icteric and nonicteric newborn Gunn rats.
Topics: Aminobenzoates; Analgesics; Aniline Compounds; Animals; Animals, Newborn; Chloramphenicol; Dapsone; | 1970 |
Differential effect of spironolactone on the ulcerogenic and anti-inflammatory activities of indomethacin.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Disease Models, Animal; Indomethacin; Intestines; Male | 1970 |