indomethacin has been researched along with Disease Exacerbation in 48 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to compare the efficacy of rectal indomethacin vs placebo in reducing the systemic inflammatory response syndrome (SIRS) score in a high-risk AP population for clinical progression." | 9.41 | Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial. ( Conwell, DL; de-Madaria, E; Greer, P; Hart, PA; Hinton, A; Lee, PJ; Machicado, JD; Mounzer, R; Papachristou, GI; Paragomi, P; Pothoulakis, I; Whitcomb, DC; Yadav, D, 2021) |
| "As a result of preclinical data demonstrating the antitumour and antimetastatic efficiency of indomethacin in murine models, and the clinical observation of occasional tumour regression in patients with advanced melanoma treated with indomethacin together with ranitidine, a Phase II study was performed of prolonged administration of these two oral agents in combination." | 9.08 | Oral indomethacin and ranitidine in advanced melanoma: a phase II study. ( Lohmann, RC; Mertens, WC, 1996) |
| "Early postnatal steroids and indomethacin in combination have been shown to increase the risk of spontaneous intestinal perforation (SIP) in infants with extremely low birth weight (ELBW), but the mechanism behind this synergistic effect is unknown." | 7.74 | A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin. ( Aschner, JL; Gaston, BM; Gordon, PV; Herman, AC; Laubach, VE; Marcinkiewicz, M, 2007) |
| " The treatment of human breast cancer cells with a nonsteroidal anti-inflammatory agent, indomethacin, reverted the high PC/low GPC pattern to a low PC/high GPC pattern indicative of a less malignant phenotype, supported by decreased invasion." | 7.73 | Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. ( Bhujwalla, ZM; Glunde, K; Jie, C, 2006) |
| " The aim of this study was to compare the efficacy of rectal indomethacin vs placebo in reducing the systemic inflammatory response syndrome (SIRS) score in a high-risk AP population for clinical progression." | 5.41 | Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial. ( Conwell, DL; de-Madaria, E; Greer, P; Hart, PA; Hinton, A; Lee, PJ; Machicado, JD; Mounzer, R; Papachristou, GI; Paragomi, P; Pothoulakis, I; Whitcomb, DC; Yadav, D, 2021) |
| "Chronic inflammation has long been associated with neoplastic progression." | 5.35 | Leukotriene B4 creates a favorable microenvironment for murine melanoma growth. ( Bachi, AL; Carneiro, CR; Correa, M; Jasiulionis, MG; Kim, FJ; Lopes, JD; Nonogaki, S, 2009) |
| "As a result of preclinical data demonstrating the antitumour and antimetastatic efficiency of indomethacin in murine models, and the clinical observation of occasional tumour regression in patients with advanced melanoma treated with indomethacin together with ranitidine, a Phase II study was performed of prolonged administration of these two oral agents in combination." | 5.08 | Oral indomethacin and ranitidine in advanced melanoma: a phase II study. ( Lohmann, RC; Mertens, WC, 1996) |
| "To compare the rate of radiographic progression in knee osteoarthritis (OA) comparing indomethacin with placebo and tiaprofenic acid with placebo." | 5.08 | Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal Investigation of Nonsteroidal Antiinflammatory Drugs in Knee Osteoarthritis. ( Berry, H; Gishen, P; Huskisson, EC; Jubb, RW; Whitehead, J, 1995) |
| "001) than indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes observed in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia, the impairment of kidney functions, and the risks for cardiovascular disease in arthritic rats." | 3.79 | Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis. ( El-Menshawy, O; Ramadan, G, 2013) |
| "In this rat model of gastrointestinal reflux, indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma." | 3.78 | Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ( Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2012) |
| " Angiotensin-converting enzyme (ACE) inhibitors were used to reduce proteinuria in all infants, and one was also treated with indomethacin." | 3.77 | Nephrotic syndrome in infancy can spontaneously resolve. ( Clothier, J; Kim, JJ; Milford, DV; Moghal, N; Sebire, NJ; Trompeter, RS, 2011) |
| "Rats receiving intracolonic administration of indomethacin develop longitudinal ulcers on the mesenteric side of the small intestine that are similar to those seen in the acute phase of Crohn's disease." | 3.74 | Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats. ( Haruma, K; Iida, M; Koga, H; Shimizu, K, 2007) |
| "Early postnatal steroids and indomethacin in combination have been shown to increase the risk of spontaneous intestinal perforation (SIP) in infants with extremely low birth weight (ELBW), but the mechanism behind this synergistic effect is unknown." | 3.74 | A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin. ( Aschner, JL; Gaston, BM; Gordon, PV; Herman, AC; Laubach, VE; Marcinkiewicz, M, 2007) |
| "During the early stages of indomethacin-induced ileitis, epithelial barrier damage and abnormal bacterial infiltration into the mucosa occurred in conjunction with initial redistribution of CD103+DC." | 3.74 | Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage. ( Jury, J; Perdue, MH; Porras, M; Silva, MA; Vergara, P, 2008) |
| " The treatment of human breast cancer cells with a nonsteroidal anti-inflammatory agent, indomethacin, reverted the high PC/low GPC pattern to a low PC/high GPC pattern indicative of a less malignant phenotype, supported by decreased invasion." | 3.73 | Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. ( Bhujwalla, ZM; Glunde, K; Jie, C, 2006) |
| "The relevance of p53 mutations to rat bladder cancer progression induced by a single injection of N-methyl-N-nitrosourea (MNU) and the chemopreventive effects of indomethacin (IM) were investigated in male F344 rats, initially given N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at a dose of 500 ppm in the drinking water for 10 weeks." | 3.69 | Lack of involvement of p53 gene mutations in N-methyl-N-nitrosourea-induced bladder tumor progression in N-butyl-N-(4-hydroxybutyl)nitrosamine-treated rats and no suppression by indomethacin. ( Kawabe, M; Orita, SI; Ozaki, M; Shibata, MA; Shirai, T; Takahashi, S, 1997) |
| "The early stage of progressive IgA nephropathy was defined as having moderate proteinuria between 1 and 2 g/day, creatinine clearance values of 70 ml/min or more, and a histological severity score of 7 or more." | 2.68 | Steroid therapy during the early stage of progressive IgA nephropathy. A 10-year follow-up study. ( Hiki, Y; Horii, A; Kobayashi, Y; Kokubo, T; Tateno, S, 1996) |
| "The causes of pruritus are numerous including xerosis, drug and photoeruptions, follicular and papular eruptions as well as infestations and infections by a wide range of organisms." | 2.68 | Pruritus in HIV-1 disease: therapy with drugs which may modulate the pattern of immune dysregulation. ( Lee, RB; Skelton, HG; Smith, KJ; Wagner, KF; Yeager, J, 1997) |
| "The indomethacin treatment increased the level of p53 in the leukemic cells, implying that COX inhibition might reduce progression of ALL by attenuating protective paracrine PGE2 signaling from bone marrow stroma to leukemic cells." | 1.51 | Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model. ( Bhagwat, S; Blomhoff, HK; Burman, MM; Duthil, E; Ford, A; Gilljam, KM; Naderi, EH; Richartz, N; Ruud, E; Skah, S, 2019) |
| "Acetaminophen is a safe antipyretic and analgesic drug within the clinically recommended dosage range, but overdose can cause fatal liver and or kidney damage." | 1.38 | Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats. ( Arimizu, K; Chuang, VT; Hirata, S; Irie, T; Ishitsuka, Y; Kadowaki, D; Kitamura, K; Maruyama, T; Narita, Y; Otagiri, M; Sumikawa, S; Taguchi, K, 2012) |
| "Diagnostic delay and misdiagnoses of unilateral headaches, as illustrated by this case, shows the clinical controversies and difficulties in diagnosing and treating this condition." | 1.37 | [A woman with unilateral headache]. ( Bekkelund, SI; Müller, KI, 2011) |
| "We report a patient with a history of migraine without aura who developed cluster headache and HC simultaneously." | 1.36 | Coexisting trigeminal autonomic cephalalgias and hemicrania continua. ( Grosberg, BM; Lipton, RB; Robbins, MS, 2010) |
| "Chronic inflammation has long been associated with neoplastic progression." | 1.35 | Leukotriene B4 creates a favorable microenvironment for murine melanoma growth. ( Bachi, AL; Carneiro, CR; Correa, M; Jasiulionis, MG; Kim, FJ; Lopes, JD; Nonogaki, S, 2009) |
| "Indomethacin (Indo) treatment of infected hamsters reduced abscess weight by 30% at 7 days post-infection presumably by inhibition of PGE2." | 1.31 | Liver function tests during amoebic liver abscess formation in indomethacin-treated hamsters. ( Mata-González, S; Ramos-Martínez, E; Sánchez-Ramírez, B; Talamás-Rohana, P; Valdez, A, 2001) |
| "When indomethacin was given with dietary soy, the previously reported suppressive effect of the cyclooxygenase inhibitor on MDA-MB-435 cell tumor progression was lost, despite reductions in tumor prostaglandin E concentrations." | 1.30 | Effects of dietary menhaden oil, soy, and a cyclooxygenase inhibitor on human breast cancer cell growth and metastasis in nude mice. ( Connolly, JM; Liu, XH; Rose, DP, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (29.17) | 18.2507 |
| 2000's | 19 (39.58) | 29.6817 |
| 2010's | 13 (27.08) | 24.3611 |
| 2020's | 2 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Machicado, JD | 1 |
| Mounzer, R | 1 |
| Paragomi, P | 1 |
| Pothoulakis, I | 1 |
| Hart, PA | 1 |
| Conwell, DL | 1 |
| de-Madaria, E | 1 |
| Greer, P | 1 |
| Yadav, D | 1 |
| Whitcomb, DC | 1 |
| Lee, PJ | 1 |
| Hinton, A | 1 |
| Papachristou, GI | 1 |
| Richartz, N | 1 |
| Duthil, E | 1 |
| Ford, A | 1 |
| Naderi, EH | 1 |
| Bhagwat, S | 1 |
| Gilljam, KM | 1 |
| Burman, MM | 1 |
| Ruud, E | 1 |
| Blomhoff, HK | 1 |
| Skah, S | 1 |
| Pini, A | 1 |
| Fazi, C | 1 |
| Nardini, P | 1 |
| Calvani, M | 1 |
| Fabbri, S | 1 |
| Guerrini, A | 1 |
| Forni, G | 1 |
| La Marca, G | 1 |
| Rosa, AC | 1 |
| Filippi, L | 1 |
| Ramadan, G | 1 |
| El-Menshawy, O | 1 |
| Rodrigues, SF | 1 |
| Fiel, LA | 1 |
| Shimada, AL | 1 |
| Pereira, NR | 1 |
| Guterres, SS | 1 |
| Pohlmann, AR | 1 |
| Farsky, SH | 1 |
| Prakash, S | 1 |
| Rathore, C | 1 |
| Jaeger, LB | 1 |
| Dohgu, S | 1 |
| Sultana, R | 1 |
| Lynch, JL | 1 |
| Owen, JB | 1 |
| Erickson, MA | 1 |
| Shah, GN | 1 |
| Price, TO | 1 |
| Fleegal-Demotta, MA | 1 |
| Butterfield, DA | 1 |
| Butterfiled, DA | 1 |
| Banks, WA | 1 |
| Bachi, AL | 1 |
| Kim, FJ | 1 |
| Nonogaki, S | 1 |
| Carneiro, CR | 1 |
| Lopes, JD | 1 |
| Jasiulionis, MG | 1 |
| Correa, M | 1 |
| Robbins, MS | 1 |
| Grosberg, BM | 1 |
| Lipton, RB | 1 |
| Takamura, T | 1 |
| Harama, D | 1 |
| Matsuoka, S | 1 |
| Shimokawa, N | 1 |
| Nakamura, Y | 1 |
| Okumura, K | 1 |
| Ogawa, H | 1 |
| Kitamura, M | 1 |
| Nakao, A | 1 |
| Avraham, R | 1 |
| Benish, M | 1 |
| Inbar, S | 1 |
| Bartal, I | 1 |
| Rosenne, E | 1 |
| Ben-Eliyahu, S | 1 |
| Yablon, LA | 1 |
| Newman, LC | 1 |
| Müller, KI | 1 |
| Bekkelund, SI | 1 |
| Kim, JJ | 1 |
| Clothier, J | 1 |
| Sebire, NJ | 1 |
| Milford, DV | 1 |
| Moghal, N | 1 |
| Trompeter, RS | 1 |
| Assar, AN | 1 |
| Esquivias, P | 1 |
| Morandeira, A | 1 |
| Escartín, A | 1 |
| Cebrián, C | 1 |
| Santander, S | 1 |
| Esteva, F | 1 |
| García-González, MA | 1 |
| Ortego, J | 1 |
| Lanas, A | 1 |
| Piazuelo, E | 1 |
| Kadowaki, D | 1 |
| Sumikawa, S | 1 |
| Arimizu, K | 1 |
| Taguchi, K | 1 |
| Kitamura, K | 1 |
| Ishitsuka, Y | 1 |
| Narita, Y | 1 |
| Irie, T | 1 |
| Chuang, VT | 1 |
| Maruyama, T | 1 |
| Otagiri, M | 1 |
| Hirata, S | 1 |
| Darmon, D | 1 |
| Goldfarb, M | 1 |
| Shina, A | 1 |
| Rosen, S | 1 |
| Heyman, SN | 1 |
| Peluffo, GD | 1 |
| Stillitani, I | 1 |
| Rodríguez, VA | 1 |
| Diament, MJ | 1 |
| Klein, SM | 1 |
| Ohta, Y | 1 |
| Kamiya, Y | 1 |
| Imai, Y | 1 |
| Arisawa, T | 1 |
| Nakano, H | 1 |
| Yang, Z | 1 |
| Nandi, J | 2 |
| Wang, J | 1 |
| Bosco, G | 1 |
| Gregory, M | 1 |
| Chung, C | 1 |
| Xie, Y | 1 |
| Yang, X | 1 |
| Camporesi, EM | 1 |
| Castellanos-Pinedo, F | 1 |
| Zurdo, M | 1 |
| Martínez-Acebes, E | 1 |
| Glunde, K | 1 |
| Jie, C | 1 |
| Bhujwalla, ZM | 1 |
| Kamata, K | 1 |
| Hosokawa, M | 1 |
| Matsumoto, T | 1 |
| Kobayashi, T | 1 |
| Shimizu, K | 1 |
| Koga, H | 1 |
| Iida, M | 1 |
| Haruma, K | 1 |
| Saud, B | 1 |
| Zinkievich, JM | 1 |
| Palma, DT | 1 |
| Levine, RA | 1 |
| Gordon, PV | 1 |
| Herman, AC | 1 |
| Marcinkiewicz, M | 1 |
| Gaston, BM | 1 |
| Laubach, VE | 1 |
| Aschner, JL | 1 |
| de Jong, D | 1 |
| Jansen, R | 1 |
| Hoefnagels, W | 1 |
| Jellesma-Eggenkamp, M | 1 |
| Verbeek, M | 1 |
| Borm, G | 1 |
| Kremer, B | 1 |
| Abraham, C | 1 |
| Hart, J | 1 |
| Locke, SM | 1 |
| Baker, AL | 1 |
| Silva, MA | 1 |
| Jury, J | 1 |
| Porras, M | 1 |
| Vergara, P | 1 |
| Perdue, MH | 1 |
| Doherty, M | 1 |
| Jones, A | 1 |
| Kobayashi, Y | 1 |
| Hiki, Y | 1 |
| Kokubo, T | 1 |
| Horii, A | 1 |
| Tateno, S | 1 |
| Mertens, WC | 1 |
| Lohmann, RC | 1 |
| Huskisson, EC | 1 |
| Berry, H | 1 |
| Gishen, P | 1 |
| Jubb, RW | 1 |
| Whitehead, J | 1 |
| Ajdary, S | 1 |
| Hosseini, MH | 1 |
| Alimohammadian, MH | 1 |
| Ozaki, M | 1 |
| Shibata, MA | 1 |
| Takahashi, S | 1 |
| Orita, SI | 1 |
| Kawabe, M | 1 |
| Shirai, T | 1 |
| Connolly, JM | 1 |
| Liu, XH | 1 |
| Rose, DP | 1 |
| Smith, KJ | 1 |
| Skelton, HG | 1 |
| Yeager, J | 1 |
| Lee, RB | 1 |
| Wagner, KF | 1 |
| Manuelidis, L | 1 |
| Fritch, W | 1 |
| Zaitsev, I | 1 |
| Blaya, C | 1 |
| Crespo, J | 1 |
| Crespo, A | 1 |
| Aliño, SF | 1 |
| Horigome, H | 1 |
| De Freitas, LA | 1 |
| Mbow, LM | 1 |
| Estay, M | 1 |
| Bleyenberg, JA | 1 |
| Titus, RG | 1 |
| Lequesne, MG | 1 |
| Walton, LJ | 1 |
| Franklin, IJ | 1 |
| Bayston, T | 1 |
| Brown, LC | 1 |
| Greenhalgh, RM | 1 |
| Taylor, GW | 1 |
| Powell, JT | 1 |
| Nilsson, SF | 1 |
| Mäepea, O | 1 |
| Alm, A | 1 |
| Narfström, K | 1 |
| Sánchez-Ramírez, B | 1 |
| Mata-González, S | 1 |
| Valdez, A | 1 |
| Ramos-Martínez, E | 1 |
| Talamás-Rohana, P | 1 |
| Cyrus, T | 1 |
| Tang, LX | 1 |
| Rokach, J | 1 |
| FitzGerald, GA | 1 |
| Praticò, D | 1 |
| Arlettaz, R | 1 |
| Archer, N | 1 |
| Wilkinson, AR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis[NCT02692391] | Phase 3 | 42 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| Effect of Indomethacin on the Progression of Alzheimer's Disease[NCT00432081] | Phase 3 | 160 participants | Interventional | 2000-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
CRP levels at 48 hours after enrollment minus CRP levels at enrollment (baseline). A negative number indicates a better outcome (less inflammation). (NCT02692391)
Timeframe: 48 hours
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | -1.43 |
| Indomethacin Suppository | -2.08 |
Enrolled subjects that died. A death indicates a worse outcome. (NCT02692391)
Timeframe: 1 month
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 1 |
| Indomethacin Suppository | 0 |
Including respiratory, renal and cardiovascular failures defined as modified Marshal score of equal and greater than 2. The minimum and maximum values in the modified Marshal score for each organ failure range from 0 to 4 with a higher value representing worse outcomes. (NCT02692391)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 6 |
| Indomethacin Suppository | 3 |
SIRS is a simple clinical score, ranging from 0-4, that utilizes objective, routine clinical parameters (body temperature, heart rate, respiratory rate or arterial carbon dioxide tension and white blood count) that directly reflect the underlying inflammatory response. A lower change in SIRS score (negative number) indicates a better outcome (less inflammation). (NCT02692391)
Timeframe: The change in the SIRS score (48 hours - baseline)
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | -0.96 |
| Indomethacin Suppository | -1 |
2 reviews available for indomethacin and Disease Exacerbation
| Article | Year |
|---|---|
Medical treatment of small abdominal aortic aneurysm.
Topics: Aortic Aneurysm, Abdominal; Cardiovascular Agents; Disease Progression; Doxycycline; Humans; Hydroxy | 2012 |
Indomethacin hastens large joint osteoarthritis in humans--how strong is the evidence?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Disease Progression; Hip Joint; Humans; Indomethacin; Knee | 1995 |
6 trials available for indomethacin and Disease Exacerbation
| Article | Year |
|---|---|
Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial.
Topics: Administration, Rectal; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Disease Progression; F | 2021 |
No effect of one-year treatment with indomethacin on Alzheimer's disease progression: a randomized controlled trial.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Disease Progression; Double-Blind Method | 2008 |
Steroid therapy during the early stage of progressive IgA nephropathy. A 10-year follow-up study.
Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Dipyridamole; Disease Prog | 1996 |
Oral indomethacin and ranitidine in advanced melanoma: a phase II study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antin | 1996 |
Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal Investigation of Nonsteroidal Antiinflammatory Drugs in Knee Osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthrography; Disease Progr | 1995 |
Pruritus in HIV-1 disease: therapy with drugs which may modulate the pattern of immune dysregulation.
Topics: Administration, Cutaneous; Administration, Topical; Anti-Inflammatory Agents; Antipruritics; Cycloox | 1997 |
40 other studies available for indomethacin and Disease Exacerbation
| Article | Year |
|---|---|
Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model.
Topics: Animals; Biomarkers; Bone Marrow; Cell Line, Tumor; Child; Child, Preschool; Cyclooxygenase Inhibito | 2019 |
Effect of Beta 3 Adrenoreceptor Modulation on Patency of the Ductus Arteriosus.
Topics: Adrenergic beta-3 Receptor Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Disease P | 2020 |
Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Atherosclerosis; | 2013 |
Lipid-Core Nanocapsules Act as a Drug Shuttle Through the Blood Brain Barrier and Reduce Glioblastoma After Intravenous or Oral Administration.
Topics: Administration, Oral; Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Line, Tumor; Diseas | 2016 |
Two Cases of Hemicrania Continua-Trigeminal Neuralgia Syndrome: Expanding the Spectrum of Trigeminal Autonomic Cephalalgia-Tic (TAC-TIC) Syndrome.
Topics: Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Disease Pro | 2017 |
Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Blotting, Western; Brain; Cy | 2009 |
Leukotriene B4 creates a favorable microenvironment for murine melanoma growth.
Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Carrageenan; Cell Growth Processes; Cell Line, Tumo | 2009 |
Coexisting trigeminal autonomic cephalalgias and hemicrania continua.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Brain; Calcium Channel Blockers; Cl | 2010 |
Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Cytochrome P-450 CYP1A1; Dextran Sulfate; Dinoprostone | 2010 |
Synergism between immunostimulation and prevention of surgery-induced immune suppression: an approach to reduce post-operative tumor progression.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Animals; Catecholamines; Cell Line, Tumor; Cycl | 2010 |
Hemicrania continua: a second case in which the remitting form evolved from the chronic form.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Causality; Disease Progression; Female; Humans; Indomethaci | 2010 |
[A woman with unilateral headache].
Topics: Chronic Disease; Cyclooxygenase 2 Inhibitors; Delayed Diagnosis; Diagnosis, Differential; Disease Pr | 2011 |
Nephrotic syndrome in infancy can spontaneously resolve.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Stero | 2011 |
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic | 2012 |
Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats.
Topics: Acetaminophen; Adenine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antioxidants; Disea | 2012 |
Effect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage.
Topics: Acute Kidney Injury; Animals; Benzamides; Contrast Media; Disease Models, Animal; Disease Progressio | 2003 |
Reduction of tumor progression and paraneoplastic syndrome development in murine lung adenocarcinoma by nonsteroidal antiinflammatory drugs.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cell Survival; Chem | 2004 |
Plaunotol prevents the progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats.
Topics: Animals; Anti-Ulcer Agents; Ascorbic Acid; Blood Flow Velocity; Cell Degranulation; Disease Progress | 2005 |
Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Progression; Electrophoresis, Polyacrylamide Ge | 2006 |
Hemicrania continua evolving from episodic paroxysmal hemicrania.
Topics: Adult; Disease Progression; Female; Humans; Indomethacin; Paroxysmal Hemicrania; Treatment Outcome | 2006 |
Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Tumor; Choline; Disease Progre | 2006 |
Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Diabetes M | 2006 |
Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cytokines; Disease Models | 2007 |
5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blotting, Western; Cyclooxygenase Inhi | 2008 |
A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Dexamethasone | 2007 |
A case of indometacin-induced acute hepatitis developing into chronic autoimmune hepatitis.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury, Chro | 2008 |
Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Blotting, Western; Dendritic Cells; | 2008 |
Recombinant interleukin-1 promotes leishmaniasis in susceptible mice.
Topics: Animals; Disease Progression; Indomethacin; Interleukin-1; Leishmaniasis, Cutaneous; Mice; Mice, Inb | 1997 |
Lack of involvement of p53 gene mutations in N-methyl-N-nitrosourea-induced bladder tumor progression in N-butyl-N-(4-hydroxybutyl)nitrosamine-treated rats and no suppression by indomethacin.
Topics: Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Carcinogens; Carcinoma, Transitional | 1997 |
Effects of dietary menhaden oil, soy, and a cyclooxygenase inhibitor on human breast cancer cell growth and metastasis in nude mice.
Topics: Animals; Cell Division; Combined Modality Therapy; Cyclooxygenase Inhibitors; Diet; Disease Progress | 1997 |
Dapsone to delay symptoms in Creutzfeldt-Jakob disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Creutzfeldt-Jakob Syndrome; Dapsone; Disease Progr | 1998 |
Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinoma, Lewis Lung; Cell Division; Cycloo | 1998 |
The contracted type of endocardial fibroelastosis.
Topics: Disease Progression; Ductus Arteriosus, Patent; Echocardiography; Endocardial Fibroelastosis; Fatal | 1999 |
Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
Topics: Animals; Antiprotozoal Agents; Cyclooxygenase Inhibitors; Disease Progression; Female; Immunity, Cel | 1999 |
Is there preliminary in-vivo evidences of an influence of nonsteroidal antiinflammatory drug treatment on osteoarthritis progression? Part I.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apazone; Disease Progression; Humans; Indomethacin; Osteoar | 1999 |
Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms.
Topics: Adolescent; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aortic Aneurysm, Abdominal; Apoptosis; Ce | 1999 |
Ocular blood flow and retinal metabolism in abyssinian cats with hereditary retinal degeneration.
Topics: Animals; Blood Flow Velocity; Blood Glucose; Cardiovascular Agents; Cats; Choroid; Disease Models, A | 2001 |
Liver function tests during amoebic liver abscess formation in indomethacin-treated hamsters.
Topics: Animals; Bilirubin; Cricetinae; Disease Progression; Entamoeba histolytica; Indomethacin; Liver; Liv | 2001 |
Lipid peroxidation and platelet activation in murine atherosclerosis.
Topics: Animals; Antioxidants; Aorta; Arteriosclerosis; Cyclooxygenase Inhibitors; Diet, Atherogenic; Dietar | 2001 |
Closure of the ductus arteriosus and development of pulmonary branch stenosis in babies of less than 32 weeks gestation.
Topics: Cardiovascular Agents; Disease Progression; Ductus Arteriosus, Patent; Female; Heart Murmurs; Humans | 2001 |