indomethacin has been researched along with Disease, Pulmonary in 49 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patent ductus arteriosus is a risk factor for pulmonary hemorrhage; however, despite halving the incidence of patent ductus arteriosus, indomethacin prophylaxis did not reduce the rate of pulmonary hemorrhage in the Trial of Indomethacin Prophylaxis in Preterms." | 9.13 | Prevention and 18-month outcomes of serious pulmonary hemorrhage in extremely low birth weight infants: results from the trial of indomethacin prophylaxis in preterms. ( Alfaleh, K; Asztalos, EV; Roberts, RS; Schmidt, B; Smyth, JA; Solimano, A, 2008) |
| "We designed the present experiments to investigate the involvement of endogenous nitric oxide synthase (NOS) inhibitors, dimethylarginine dimethylaminohydrolase (DDAH) as a hydrolyzing enzyme of the NOS inhibitors, NOS, arginase which shares l-arginine as a common substrate with NOS, and endothelin-1 (ET-1) in the pulmonary dysfunction after induction of experimental subarachnoid hemorrhage (SAH) in the rabbit." | 7.74 | Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit. ( Azuma, H; Imamura, M; Isotani, E; Mizuno, Y; Nagai, A; Ohno, K, 2008) |
| "Granulomas were associated with a significant decrease in anti-mycobacterial immunity manifested by a drop in delayed-type hypersensitivity reactions and antibody titres." | 5.29 | T-cell lung granulomas induced by sepharose-coupled Mycobacterium tuberculosis protein antigens: immunosuppressive phenomena reversed with cyclophosphamide and indomethacin. ( Hernández-Pando, R; Mancilla, R; Orozco, H, 1995) |
| "A patent ductus arteriosus is a risk factor for pulmonary hemorrhage; however, despite halving the incidence of patent ductus arteriosus, indomethacin prophylaxis did not reduce the rate of pulmonary hemorrhage in the Trial of Indomethacin Prophylaxis in Preterms." | 5.13 | Prevention and 18-month outcomes of serious pulmonary hemorrhage in extremely low birth weight infants: results from the trial of indomethacin prophylaxis in preterms. ( Alfaleh, K; Asztalos, EV; Roberts, RS; Schmidt, B; Smyth, JA; Solimano, A, 2008) |
| "The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g)." | 5.09 | Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. ( Davis, P; Moddemann, D; Ohlsson, A; Roberts, RS; Saigal, S; Schmidt, B; Solimano, A; Vincer, M; Wright, LL, 2001) |
| "We designed the present experiments to investigate the involvement of endogenous nitric oxide synthase (NOS) inhibitors, dimethylarginine dimethylaminohydrolase (DDAH) as a hydrolyzing enzyme of the NOS inhibitors, NOS, arginase which shares l-arginine as a common substrate with NOS, and endothelin-1 (ET-1) in the pulmonary dysfunction after induction of experimental subarachnoid hemorrhage (SAH) in the rabbit." | 3.74 | Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit. ( Azuma, H; Imamura, M; Isotani, E; Mizuno, Y; Nagai, A; Ohno, K, 2008) |
| " Since exposure to ozone also caused neuronal M2 receptors to become dependent upon cyclooxygenase the effects of viral infection are likely to be due to inflammation." | 3.69 | Viral infection induces dependence of neuronal M2 muscarinic receptors on cyclooxygenase in guinea pig lung. ( Fryer, AD; Jacoby, DB; Kahn, RM; Okanlami, OA, 1996) |
| "Furthermore, chronic pulmonary disease of prematurity was similar in the two groups despite a reduction in the incidence of patent ductus arteriosus in the indomethacin group." | 2.66 | Early intravenous indomethacin prolongs respiratory support in very low birth weight infants. ( Allen, A; Evans, J; Fraser, A; Nwaesei, C; Rees, E; Stinson, D; Vincer, M, 1987) |
| "Closing patent ductus arteriosus (PDA) is a widely accepted approach in the management of very low birth weight (VLBW) infants." | 1.46 | Patent ductus arteriosus in premature infants: to treat or not to treat? ( Alqahtani, S; Aly, H; Alyami, K; El-Dib, M; Ibrahim, AN; Mohamed, MA, 2017) |
| "Indomethacin treatment, which inhibited PGE2 production in both strains, suppressed the protection in Tg5 mice, supporting the idea that IL-9 controls blm-induced lung injury through a prostaglandin-dependent mechanism." | 1.33 | IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins. ( Arras, M; Brombacher, F; Delos, M; Heilier, JF; Huaux, F; Lison, D; Louahed, J; Renauld, JC, 2005) |
| "Indomethacin failed to inhibit the LTB4-induced increases in Kf and W/D ratio." | 1.29 | Leukotriene B4 induces lung injury in the rabbit: role of neutrophils and effect of indomethacin. ( Homma, T; Kobayashi, T; Koyama, S; Nakagawa, S; Yoshimura, K, 1993) |
| "Granulomas were associated with a significant decrease in anti-mycobacterial immunity manifested by a drop in delayed-type hypersensitivity reactions and antibody titres." | 1.29 | T-cell lung granulomas induced by sepharose-coupled Mycobacterium tuberculosis protein antigens: immunosuppressive phenomena reversed with cyclophosphamide and indomethacin. ( Hernández-Pando, R; Mancilla, R; Orozco, H, 1995) |
| " The protective effect of inhibitors when administered before, but not after, 3MI dosing suggests it is the inhibition of PHS activity in activation of 3MI, not in production of prostanoids which prevented the disease process." | 1.28 | The role of prostaglandin H synthase in 3-methylindole-induced pneumotoxicity in goat. ( Acton, KS; Boermans, HJ; Bray, TM, 1992) |
| "Pretreatment with indomethacin did not attenuate the neutrophil sequestration within the pulmonary parenchyma." | 1.28 | Acute lung injury following reperfusion after ischemia in the hind limbs of rats. ( Cashmer, B; Oldham, K; Punch, J; Rees, R; Smith, DJ; Wilkins, E, 1991) |
| "A patient had liver cirrhosis associated with marked hypoxemia." | 1.28 | Effects of indomethacin on hepatogenic pulmonary angiodysplasia. ( Okumura, M; Sakaguchi, S; Sasaki, H; Shijo, H; Yuh, K, 1991) |
| "Indomethacin prevented the increase in both cyclooxygenase metabolites, but had no effect on the pulmonary hypertension." | 1.28 | Pulmonary hypertensive response to foreign body microemboli. ( Fairman, RP; Farber, HW; Glauser, FL; Millan, JE; Rounds, S, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (36.73) | 18.7374 |
| 1990's | 17 (34.69) | 18.2507 |
| 2000's | 8 (16.33) | 29.6817 |
| 2010's | 4 (8.16) | 24.3611 |
| 2020's | 2 (4.08) | 2.80 |
| Authors | Studies |
|---|---|
| Marini, D | 1 |
| Xu, J | 1 |
| Sun, L | 1 |
| Jaeggi, E | 1 |
| Seed, M | 1 |
| Mitra, S | 1 |
| Scrivens, A | 1 |
| von Kursell, AM | 1 |
| Disher, T | 1 |
| Mohamed, MA | 1 |
| El-Dib, M | 1 |
| Alqahtani, S | 1 |
| Alyami, K | 1 |
| Ibrahim, AN | 1 |
| Aly, H | 1 |
| Alfaleh, KM | 1 |
| Al Luwaimi, E | 1 |
| Alkharfi, TM | 1 |
| Al-Alaiyan, SA | 1 |
| Adrouche-Amrani, L | 1 |
| Green, RS | 1 |
| Gluck, KM | 1 |
| Lin, J | 1 |
| Scott, NM | 1 |
| Ng, RL | 1 |
| Strickland, DH | 1 |
| Bisley, JL | 1 |
| Bazely, SA | 1 |
| Gorman, S | 1 |
| Norval, M | 1 |
| Hart, PH | 1 |
| Hashimoto, K | 1 |
| Sheller, JR | 1 |
| Morrow, JD | 1 |
| Collins, RD | 1 |
| Goleniewska, K | 1 |
| O'Neal, J | 1 |
| Zhou, W | 1 |
| Ji, S | 1 |
| Mitchell, DB | 1 |
| Graham, BS | 1 |
| Peebles, RS | 1 |
| Arras, M | 1 |
| Louahed, J | 1 |
| Heilier, JF | 1 |
| Delos, M | 1 |
| Brombacher, F | 1 |
| Renauld, JC | 1 |
| Lison, D | 1 |
| Huaux, F | 1 |
| Levene, M | 1 |
| Mizuno, Y | 1 |
| Isotani, E | 1 |
| Ohno, K | 1 |
| Nagai, A | 1 |
| Imamura, M | 1 |
| Azuma, H | 1 |
| Alfaleh, K | 1 |
| Smyth, JA | 1 |
| Roberts, RS | 2 |
| Solimano, A | 2 |
| Asztalos, EV | 1 |
| Schmidt, B | 2 |
| Burrows, FG | 1 |
| Ducobu, J | 1 |
| Dupont, P | 1 |
| Hudspith, BN | 1 |
| Brostoff, J | 1 |
| McNicol, MW | 1 |
| Johnson, NM | 1 |
| Kunkel, SL | 1 |
| Chensue, SW | 1 |
| Mouton, C | 1 |
| Higashi, GI | 1 |
| Hageman, JR | 2 |
| McCulloch, K | 2 |
| Gora, P | 1 |
| Olsen, EK | 1 |
| Pachman, L | 3 |
| Hunt, CE | 3 |
| Merritt, TA | 1 |
| Harris, JP | 1 |
| Roghmann, K | 1 |
| Wood, B | 1 |
| Campanella, V | 1 |
| Alexson, C | 1 |
| Manning, J | 1 |
| Shapiro, DL | 1 |
| Dickey, BF | 1 |
| Thrall, RS | 1 |
| McCormick, JR | 1 |
| Ward, PA | 1 |
| Yamaguchi, K | 1 |
| Mori, M | 1 |
| Takasugi, T | 1 |
| Oyamada, Y | 1 |
| Kawai, A | 1 |
| Asano, K | 1 |
| Aoki, T | 1 |
| Fujita, H | 1 |
| Suzuki, Y | 1 |
| Rabinovici, R | 1 |
| Bugelski, PJ | 1 |
| Esser, KM | 1 |
| Hillegass, LM | 1 |
| Griswold, DE | 1 |
| Vernick, J | 1 |
| Feuerstein, G | 1 |
| Kruse-Elliott, KT | 1 |
| Olson, NC | 1 |
| Yoshimura, K | 1 |
| Nakagawa, S | 1 |
| Koyama, S | 1 |
| Kobayashi, T | 1 |
| Homma, T | 1 |
| Huang, YC | 1 |
| Kennedy, TP | 1 |
| Su, YF | 1 |
| Watkins, WD | 1 |
| Whorton, AR | 1 |
| Piantadosi, CA | 1 |
| Hernández-Pando, R | 1 |
| Orozco, H | 1 |
| Mancilla, R | 1 |
| Kahn, RM | 1 |
| Okanlami, OA | 1 |
| Jacoby, DB | 1 |
| Fryer, AD | 1 |
| Jiang, XW | 1 |
| Kambara, K | 1 |
| Gotoh, N | 1 |
| Nishigaki, K | 1 |
| Fujiwara, H | 1 |
| Leeman, M | 1 |
| de Beyl, VZ | 1 |
| Biarent, D | 1 |
| Maggiorini, M | 1 |
| Mélot, C | 1 |
| Naeije, R | 1 |
| Watterberg, KL | 1 |
| Scott, SM | 1 |
| Backstrom, C | 1 |
| Gifford, KL | 1 |
| Cook, KL | 1 |
| Stark, AR | 1 |
| Carlo, WA | 1 |
| Tyson, JE | 1 |
| Papile, LA | 1 |
| Wright, LL | 2 |
| Shankaran, S | 1 |
| Donovan, EF | 1 |
| Oh, W | 2 |
| Bauer, CR | 1 |
| Saha, S | 1 |
| Poole, WK | 1 |
| Stoll, BJ | 1 |
| Davis, P | 1 |
| Moddemann, D | 1 |
| Ohlsson, A | 1 |
| Saigal, S | 1 |
| Vincer, M | 2 |
| Yam, J | 1 |
| Roberts, RJ | 1 |
| Pina Boronat, R | 1 |
| Buzón Rueda, JL | 1 |
| Arenas Mirave, JI | 1 |
| Boixeda Miquel, D | 1 |
| Hernández Ranz, F | 1 |
| Moreira Vicente, V | 1 |
| Rodríguez San Pedro, F | 1 |
| Acton, KS | 1 |
| Boermans, HJ | 1 |
| Bray, TM | 1 |
| Okuda, M | 1 |
| Lee, HC | 1 |
| Chance, B | 1 |
| Cohen, PJ | 1 |
| Kumar, C | 1 |
| Wurtz, MM | 1 |
| Stephenson, AH | 1 |
| Sprague, RS | 1 |
| Lonigro, AJ | 1 |
| Punch, J | 1 |
| Rees, R | 1 |
| Cashmer, B | 1 |
| Oldham, K | 1 |
| Wilkins, E | 1 |
| Smith, DJ | 1 |
| Shijo, H | 2 |
| Sasaki, H | 2 |
| Miyajima, Y | 1 |
| Okumura, M | 2 |
| Zanaboni, PB | 1 |
| Bradley, JD | 1 |
| Webster, RO | 1 |
| Dahms, TE | 1 |
| Yuh, K | 1 |
| Sakaguchi, S | 1 |
| Farber, HW | 1 |
| Fairman, RP | 1 |
| Rounds, S | 1 |
| Millan, JE | 1 |
| Glauser, FL | 1 |
| Cobb, M | 1 |
| Quade, B | 1 |
| Crussi, F | 1 |
| Roberts, JD | 1 |
| Smith, LJ | 1 |
| Sommers, E | 1 |
| Farrukh, IS | 1 |
| Michael, JR | 1 |
| Peters, SP | 1 |
| Sciuto, AM | 1 |
| Adkinson, NF | 1 |
| Freeland, HS | 1 |
| Paky, A | 1 |
| Spannhake, EW | 1 |
| Summer, WR | 1 |
| Gurtner, GH | 1 |
| Burrell, R | 1 |
| Lantz, RC | 1 |
| Hinton, DE | 1 |
| Allen, A | 1 |
| Evans, J | 1 |
| Nwaesei, C | 1 |
| Stinson, D | 1 |
| Rees, E | 1 |
| Fraser, A | 1 |
| Ryrfeldt, A | 1 |
| Kröll, F | 1 |
| Berggren, M | 1 |
| Moldéus, P | 1 |
| Eden, E | 1 |
| Turino, GM | 1 |
| Sandler, H | 1 |
| Gerdin, B | 1 |
| Saldeen, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Early Targeted Ibuprofene Treatment of Patent Ductus Arteriosus (PDA) on Long Term Neurodevelopmental Outcome in Very Premature Infants (TRIOCAPI)[NCT01630278] | Phase 3 | 363 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253] | Phase 3 | 44 participants (Anticipated) | Interventional | 2016-03-31 | Completed | ||
| Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)[NCT00009646] | Phase 3 | 1,202 participants (Actual) | Interventional | 1993-11-30 | Completed | ||
| Randomized Trial of Minimal Ventilator Support and Early Corticosteroid Therapy to Increase Survival Without Chronic Lung Disease in Extremely-Low-Birth-Weight Infants[NCT00005777] | Phase 3 | 220 participants (Actual) | Interventional | 1998-02-28 | Terminated (stopped due to The trial was halted because of unanticipated nonrespiratory adverse events related to dexamethasone therapy.) | ||
| High-Dose Erythropoietin in Very Low Birth Weight Infants for the Potential Treatment of Prematurity-Related Cerebral Hemorrhagic-Ischemic Injury: A Phase II Safety/Tolerability Study[NCT00589953] | Phase 2 | 22 participants (Actual) | Interventional | 2007-07-31 | Terminated | ||
| Follow-up Visit of High Risk Infants[NCT00009633] | 68,000 participants (Anticipated) | Observational | 1993-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for indomethacin and Disease, Pulmonary
| Article | Year |
|---|---|
Current and future role of fetal cardiovascular MRI in the setting of fetal cardiac interventions.
Topics: Anemia; Anti-Inflammatory Agents, Non-Steroidal; Atrial Septum; Blood Transfusion, Intrauterine; Duc | 2020 |
Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cause of Death; Cerebral Intraventricular Hemorrhage; Chron | 2020 |
Minimising neonatal brain injury: how research in the past five years has changed my clinical practice.
Topics: Animals; Birth Injuries; Brain Diseases; Dexamethasone; Disease Models, Animal; Ethamsylate; Humans; | 2007 |
5 trials available for indomethacin and Disease, Pulmonary
| Article | Year |
|---|---|
Prevention and 18-month outcomes of serious pulmonary hemorrhage in extremely low birth weight infants: results from the trial of indomethacin prophylaxis in preterms.
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Hemorrhage; Humans; Indomethacin; Infant; Infa | 2008 |
Early closure of the patent ductus arteriosus in very low-birth-weight infants: a controlled trial.
Topics: Bronchial Diseases; Clinical Trials as Topic; Ductus Arteriosus, Patent; Humans; Indomethacin; Infan | 1981 |
Adverse effects of early dexamethasone treatment in extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dexamethasone; D | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Early intravenous indomethacin prolongs respiratory support in very low birth weight infants.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Infant, Low Birth Weigh | 1987 |
41 other studies available for indomethacin and Disease, Pulmonary
| Article | Year |
|---|---|
Patent ductus arteriosus in premature infants: to treat or not to treat?
Topics: Conservative Treatment; Cyclooxygenase Inhibitors; Databases, Factual; Disease Management; District | 2017 |
A decision aid for considering indomethacin prophylaxis vs. symptomatic treatment of PDA for extreme low birth weight infants.
Topics: Adult; Bronchopulmonary Dysplasia; Cardiovascular Agents; Decision Support Techniques; Ductus Arteri | 2011 |
Failure of a repeat course of cyclooxygenase inhibitor to close a PDA is a risk factor for developing chronic lung disease in ELBW infants.
Topics: Chronic Disease; Cyclooxygenase Inhibitors; Drug Administration Schedule; Ductus Arteriosus, Patent; | 2012 |
Toward homeostasis: regulatory dendritic cells from the bone marrow of mice with inflammation of the airways and peritoneal cavity.
Topics: Alum Compounds; Animals; B7-2 Antigen; Bone Marrow Cells; CD11c Antigen; Cell Differentiation; Cell | 2012 |
Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclooxygenase Inhibitors; Cytokine | 2005 |
IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Indomethacin; Interleukin-9; L-Lactate Dehydrogena | 2005 |
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit.
Topics: Acetylcholine; Amidohydrolases; Animals; Arginase; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Respo | 2008 |
Pulmonary nodules in rheumatoid disease: a report of two cases.
Topics: Arthritis, Rheumatoid; Humans; Indomethacin; Lung Diseases; Male; Middle Aged; Pleural Effusion; Pne | 1967 |
[Inhibition of prostaglandins in the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)].
Topics: Adult; Aged; Aspirin; Brain Diseases; Ethanol; Female; Humans; Inappropriate ADH Syndrome; Indometha | 1983 |
Anergy in sarcoidosis: the role of interleukin-1 and prostaglandins in the depressed in vitro lymphocyte response.
Topics: Adult; Aged; Concanavalin A; Dinoprostone; Female; Humans; Indomethacin; Interleukin-1; Lipopolysacc | 1984 |
Role of lipoxygenase products in murine pulmonary granuloma formation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Female; Granuloma; Histocomp | 1984 |
Intralipid alterations in pulmonary prostaglandin metabolism and gas exchange.
Topics: Animals; Blood Gas Analysis; Fat Emulsions, Intravenous; Indomethacin; Lung; Lung Diseases; Prostagl | 1983 |
Oleic-acid-induced lung injury in the rat. Failure of indomethacin treatment or complement depletion to ablate lung injury.
Topics: Animals; Complement C3; Complement System Proteins; Disease Models, Animal; Elapid Venoms; Indometha | 1981 |
[Effects of vasoactive cyclooxygenase products on shunt flow and extravascular lung water in acute lung injuries].
Topics: Acute Disease; Animals; Arachidonic Acids; Dogs; Epoprostenol; Extravascular Lung Water; Indomethaci | 1994 |
Tumor necrosis factor-alpha mediates endotoxin-induced lung injury in platelet activating factor-primed rats.
Topics: Animals; Antibodies, Monoclonal; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cricetinae; I | 1993 |
CGS 8515 and indomethacin attenuate cytokine-induced cardiopulmonary dysfunction in pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Albumins; Animals; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Ch | 1993 |
Leukotriene B4 induces lung injury in the rabbit: role of neutrophils and effect of indomethacin.
Topics: Animals; Arachidonic Acid; Capillary Permeability; In Vitro Techniques; Indomethacin; Leukotriene B4 | 1993 |
Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung.
Topics: Animals; Arachidonic Acids; Benzoquinones; Blood Pressure; Bronchoconstriction; Humans; Hypertension | 1993 |
T-cell lung granulomas induced by sepharose-coupled Mycobacterium tuberculosis protein antigens: immunosuppressive phenomena reversed with cyclophosphamide and indomethacin.
Topics: Animals; Antigens, Bacterial; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Electrophoresis, Polya | 1995 |
Viral infection induces dependence of neuronal M2 muscarinic receptors on cyclooxygenase in guinea pig lung.
Topics: Animals; Antibodies, Viral; Benzoquinones; Cells, Cultured; Cyclooxygenase Inhibitors; Electric Stim | 1996 |
Effects of low-dose Beraprost sodium, a stable prostaglandin I2 analogue, on reperfusion injury to rabbit lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Anti-Inflammatory Agents; Anti-Inflamma | 1998 |
Inhibition of cyclooxygenase and nitric oxide synthase in hypoxic vasoconstriction and oleic acid-induced lung injury.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Dogs; Enzyme Inhibitors; Hypoxia; Indomethacin; | 1999 |
Links between early adrenal function and respiratory outcome in preterm infants: airway inflammation and patent ductus arteriosus.
Topics: Adrenal Insufficiency; Bronchoalveolar Lavage Fluid; Bronchopulmonary Dysplasia; Chronic Disease; Du | 2000 |
Pharmacological alteration of oxygen-induced lung toxicity.
Topics: Aminophylline; Animals; Dexamethasone; Indomethacin; Lung Diseases; Male; Meclofenamic Acid; Oxygen; | 1979 |
[Response to the administration of indomethacin in a case of paraneoplastic hypercalcemia].
Topics: Aged; Carcinoma, Squamous Cell; Dexamethasone; Drug Evaluation; Humans; Hypercalcemia; Indomethacin; | 1977 |
The role of prostaglandin H synthase in 3-methylindole-induced pneumotoxicity in goat.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Goat Diseases; Goats; Ind | 1992 |
Phorbol myristate acetate-induced lung injury: involvement of reactive oxygen species.
Topics: Acridines; Animals; Catalase; Indomethacin; Luminescent Measurements; Lung; Lung Diseases; Male; Pre | 1992 |
Enhanced microvascular permeability of PMA-induced acute lung injury is not mediated by cyclooxygenase products.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Permeability; Dogs; In Vitro Techniques; Indomethac | 1992 |
Acute lung injury following reperfusion after ischemia in the hind limbs of rats.
Topics: Allopurinol; Animals; Capillary Permeability; Catalase; Dimethyl Sulfoxide; Free Radicals; Hindlimb; | 1991 |
Prostaglandin F2 alpha and indomethacin in hepatogenic pulmonary angiodysplasia. Effects on pulmonary hemodynamics and gas exchange.
Topics: Aged; Dilatation, Pathologic; Dinoprost; Drug Therapy, Combination; Hemodynamics; Humans; Indomethac | 1991 |
Cyclooxygenase inhibitors prevent ethchlorvynol-induced injury in rat and rabbit lungs.
Topics: Animals; Capillary Permeability; Cyclooxygenase Inhibitors; Ethchlorvynol; Ibuprofen; In Vitro Techn | 1991 |
Effects of indomethacin on hepatogenic pulmonary angiodysplasia.
Topics: Arteriovenous Fistula; Humans; Hypoxia; Indomethacin; Liver Cirrhosis; Lung; Lung Diseases; Male; Mi | 1991 |
Pulmonary hypertensive response to foreign body microemboli.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Chromone | 1990 |
Oleic acid lung injury increases plasma prostaglandin levels.
Topics: Animals; Indomethacin; Lung Diseases; Oleic Acids; Prostaglandins; Rabbits | 1989 |
Pulmonary oxygen toxicity in the guinea pig. Effect of indomethacin.
Topics: Animals; Bronchi; Elasticity; Female; Guinea Pigs; Indomethacin; Lung; Lung Diseases; Oxygen | 1989 |
Hyperoxic lung injury in mice: a possible protective role for prostacyclin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Epoprostenol; Indomethac | 1986 |
The role of cyclooxygenase and lipoxygenase mediators in oxidant-induced lung injury.
Topics: 5,8,11,14-Eicosatetraynoic Acid; 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Chromones; F | 1988 |
Mediators of pulmonary injury induced by inhalation of bacterial endotoxin.
Topics: Animals; Blood Platelets; Blood Volume; Capillaries; Capillary Permeability; Complement System Prote | 1988 |
Hydroperoxide and cigarette smoke induced effects on lung mechanics and glutathione status in rat isolated perfused and ventilated lungs.
Topics: Animals; Bronchi; Constriction, Pathologic; Drug Synergism; Glutathione; Indomethacin; Lung; Lung Di | 1988 |
Secretion of interleukin 1/leucocytic pyrogen from endotoxin-stimulated human alveolar macrophages is unaffected by indomethacin.
Topics: Animals; Dialysis; Endotoxins; Humans; Indomethacin; Interleukin-1; Lung Diseases; Macrophage Activa | 1986 |
Studies on the role of thromboxane in thrombin-induced pulmonary insufficiency in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cattle; Fibrinogen; Fibrinolysis; Imidazoles; | 1986 |