indomethacin has been researched along with Dilatation, Pathologic in 23 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Dilatation, Pathologic: The condition of an anatomical structure's being dilated beyond normal dimensions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus." | 7.69 | Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994) |
| "The objective of this study was to trigger the formation of rat abdominal aortic aneurysm by applying calcium chloride periarterially and then to detect the degree of prevention of aneurysm occurrence by oral introduction of indomethacin in some of the rats." | 3.73 | Influence of indomethacin in the rat aneurysm model. ( Erdoğan, F; Erkut, B; Karapolat, S; Koçak, H; Unlu, Y, 2006) |
| "Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus." | 3.69 | Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994) |
| "Furosemide was also s." | 1.36 | In vivo dilatation of the ductus arteriosus induced by furosemide in the rat. ( Momma, K; Nakanishi, T; Toyoshima, K, 2010) |
| "Varicose veins are a common disorder of extensive venous dilation and remodeling with an as-yet unclear mechanism." | 1.34 | Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation. ( Khalil, RA; Raffetto, JD; Ross, RL, 2007) |
| "The child was shown to have Bartter syndrome." | 1.28 | Transient gall bladder dilatation associated with hypokalaemia in a patient with Bartter syndrome. ( Drachman, R; Drukker, A; Goren, A; Hadas-Halperin, I, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Premkumar, A | 1 |
| Sinha, N | 1 |
| Miller, ES | 2 |
| Peaceman, AM | 1 |
| Caletti, MG | 1 |
| Balestracci, A | 1 |
| Di Pinto, D | 1 |
| Grobman, WA | 1 |
| Fonseca, L | 1 |
| Robinson, BK | 1 |
| Toyoshima, K | 1 |
| Momma, K | 2 |
| Nakanishi, T | 1 |
| Miyoshi, T | 1 |
| Ikeda, T | 1 |
| Yoshimatsu, J | 1 |
| Ikeda, Y | 1 |
| Ishibashi-Ueda, H | 1 |
| Tabernero, A | 1 |
| Schneider, F | 1 |
| Potenza, MA | 1 |
| Randriamboavonjy, V | 1 |
| Chasserot, S | 1 |
| Wolf, P | 1 |
| Mitolo-Chieppa, D | 1 |
| Stoclet, JC | 1 |
| Andriantsitohaina, R | 1 |
| Wigg, SJ | 1 |
| Tare, M | 1 |
| Forbes, J | 1 |
| Cooper, ME | 1 |
| Thomas, MC | 1 |
| Coleman, HA | 1 |
| Parkington, HC | 1 |
| O'Brien, RC | 1 |
| Karapolat, S | 1 |
| Unlu, Y | 1 |
| Erkut, B | 1 |
| Koçak, H | 1 |
| Erdoğan, F | 1 |
| Raffetto, JD | 1 |
| Ross, RL | 1 |
| Khalil, RA | 1 |
| Hintze, TH | 1 |
| Vatner, SF | 1 |
| Gerber, JG | 1 |
| Nies, AS | 1 |
| Lewis, DF | 1 |
| Grimshaw, A | 1 |
| Brooks, G | 1 |
| Dunnihoo, DR | 1 |
| Otterson, WN | 1 |
| van der Heijden, BJ | 1 |
| Carlus, C | 1 |
| Narcy, F | 1 |
| Bavoux, F | 1 |
| Delezoide, AL | 1 |
| Gubler, MC | 1 |
| Takahashi, Y | 1 |
| Harada, K | 1 |
| Ishida, A | 1 |
| Tanaka, T | 1 |
| Tsuda, A | 1 |
| Takada, G | 1 |
| Rowlands, S | 1 |
| Kasby, C | 1 |
| Poon, C | 1 |
| Murray, H | 1 |
| Golding, EM | 1 |
| You, J | 1 |
| Robertson, CS | 1 |
| Bryan, RM | 1 |
| Komiyama, M | 1 |
| Kitano, S | 1 |
| Sakamoto, H | 1 |
| Ehara, E | 1 |
| Miyagi, N | 1 |
| Kusuda, S | 1 |
| Higgs, GA | 1 |
| Cardinal, DC | 1 |
| Moncada, S | 1 |
| Vane, JR | 1 |
| Valles, M | 1 |
| Botey, A | 1 |
| Bergada, E | 1 |
| Revert, L | 1 |
| Birnbaum, M | 1 |
| Shijo, H | 1 |
| Sasaki, H | 1 |
| Miyajima, Y | 1 |
| Okumura, M | 1 |
| Takao, A | 1 |
| Goren, A | 1 |
| Drachman, R | 1 |
| Hadas-Halperin, I | 1 |
| Drukker, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Efficacy of Emergency Double-level and Single Cervical Cerclage in Cervical Insufficiency in the Second Trimester of Pregnancy - Multicenter Prospective Randomized Trial[NCT05268640] | 78 participants (Anticipated) | Interventional | 2022-03-11 | Recruiting | |||
| Role in Emergent Cerclage of Indomethacin and Antibiotics[NCT01114516] | 53 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Median birthweight (NCT01114516)
Timeframe: 24 weeks
| Intervention | grams (Median) |
|---|---|
| Control | 2488 |
| Indomethacin and Antibiotics | 2850 |
Median gestational age at delivery (NCT01114516)
Timeframe: 24 weeks
| Intervention | weeks (Median) |
|---|---|
| Control | 31.1 |
| Indomethacin and Antibiotics | 34.8 |
Median gestational latency achieved Between Cerclage Placement and Time of Delivery (NCT01114516)
Timeframe: 24 weeks
| Intervention | days (Median) |
|---|---|
| Control | 80 |
| Indomethacin and Antibiotics | 97 |
The frequency of achieving a gestational latency of more than 28 days (NCT01114516)
Timeframe: 28 days postpartum
| Intervention | percentage of participants (Number) |
|---|---|
| Control | 62.5 |
| Indomethacin and Antibiotics | 92.3 |
Days spent in the neonatal intensive care unit (NCT01114516)
Timeframe: 1 year
| Intervention | days (Median) |
|---|---|
| Control | 95 |
| Indomethacin and Antibiotics | 43 |
1 review available for indomethacin and Dilatation, Pathologic
| Article | Year |
|---|---|
[Kidney and pregnancy].
Topics: Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Chloramphenicol; Creatin | 1976 |
2 trials available for indomethacin and Dilatation, Pathologic
| Article | Year |
|---|---|
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2014 |
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2014 |
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2014 |
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2014 |
A comparison of magnesium sulfate and indomethacin to magnesium sulfate only for tocolysis in preterm labor with advanced cervical dilation.
Topics: Adult; Cervix Uteri; Dilatation, Pathologic; Drug Therapy, Combination; Female; Humans; Indomethacin | 1995 |
20 other studies available for indomethacin and Dilatation, Pathologic
| Article | Year |
|---|---|
Perioperative Use of Cefazolin and Indomethacin for Physical Examination-Indicated Cerclages to Improve Gestational Latency.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2020 |
Pre- and post-treatment urinary tract findings in children with nephrogenic diabetes insipidus.
Topics: Amiloride; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Combined Modality Thera | 2014 |
In vivo dilatation of the ductus arteriosus induced by furosemide in the rat.
Topics: Animals; Animals, Newborn; Cesarean Section; Cyclooxygenase Inhibitors; Dilatation, Pathologic; Dise | 2010 |
Fetal pulmonary thrombosis.
Topics: Adult; Chylothorax; Dilatation, Pathologic; Fatal Outcome; Female; Fetal Distress; Humans; Hydrops F | 2013 |
Cyclooxygenase-2 and inducible nitric oxide synthase in omental arteries harvested from patients with severe liver diseases: immuno-localization and influence on vascular tone.
Topics: Adult; Arteries; Blotting, Western; Carcinoma, Hepatocellular; Case-Control Studies; Cyclooxygenase | 2003 |
Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats.
Topics: Acetylcholine; Animals; Australia; Biomarkers; Blood Glucose; Body Weight; Diabetes Mellitus, Experi | 2004 |
Influence of indomethacin in the rat aneurysm model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Aortic Ane | 2006 |
Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation.
Topics: Animals; Cromakalim; Cyclooxygenase Inhibitors; Dilatation, Pathologic; Endothelium, Vascular; Enzym | 2007 |
Reactive dilation of large coronary arteries in conscious dogs.
Topics: Aminophylline; Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Circulation; Coronary | 1984 |
Furosemide-induced vasodilation: importance of the state of hydration and filtration.
Topics: Animals; Blood Flow Velocity; Dehydration; Desoxycorticosterone; Dilatation, Pathologic; Dogs; Femal | 1980 |
Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin.
Topics: Adult; Anuria; Dilatation, Pathologic; Female; Fetal Death; Humans; Immunohistochemistry; Indomethac | 1994 |
Doppler echocardiographic findings of indomethacin-induced occlusion of the fetal ductus arteriosus.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cesarean Section; Cyclooxygenase Inhibitors; Dilatat | 1996 |
Antenatal ultrasound diagnosis of dilated fetal bowel due to congenital chloride diarrhoea.
Topics: Adult; Chlorides; Diarrhea; Dilatation, Pathologic; Feces; Female; Humans; Indomethacin; Intestines; | 1996 |
Potentiated endothelium-derived hyperpolarizing factor-mediated dilations in cerebral arteries following mild head injury.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Biological Factors; Brain Injuries; Charybdot | 2001 |
Rapid normalization of marked dilatation of the cerebral duro-venous system in a newborn infant mimicking a great vein of Galen varix.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebral Veins; Diagnosis, Differential; Dilatation, Pathol | 2001 |
Microcirculatory effects of prostacyclin (PGI2) in the hamster cheek pouch.
Topics: Animals; Arterioles; Bradykinin; Cheek; Cricetinae; Dilatation, Pathologic; Dose-Response Relationsh | 1979 |
[Indomethacin in Bartter's syndrome].
Topics: Angiotensin II; Bartter Syndrome; Child; Dilatation, Pathologic; Female; Humans; Hyperaldosteronism; | 1978 |
Prostaglandin F2 alpha and indomethacin in hepatogenic pulmonary angiodysplasia. Effects on pulmonary hemodynamics and gas exchange.
Topics: Aged; Dilatation, Pathologic; Dinoprost; Drug Therapy, Combination; Hemodynamics; Humans; Indomethac | 1991 |
Right ventricular concentric hypertrophy and left ventricular dilatation by ductal constriction in fetal rats.
Topics: Animals; Cardiomegaly; Constriction, Pathologic; Dilatation, Pathologic; Ductus Arteriosus; Female; | 1989 |
Transient gall bladder dilatation associated with hypokalaemia in a patient with Bartter syndrome.
Topics: Bartter Syndrome; Dilatation, Pathologic; Gallbladder Diseases; Humans; Hyperaldosteronism; Hypokale | 1989 |