indomethacin has been researched along with Diarrhea in 79 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera." | 9.05 | Indomethacin and chloroquine fail to inhibit fluid loss in cholera. ( Butler, T; Rabbani, GH, 1985) |
| "Results of these studies demonstrate that provision of additional NO substrate in the form of L-arginine incites prostaglandin-dependent secretory diarrhea and does not promote epithelial defense or barrier function of C." | 7.74 | Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. ( Coccaro, MR; Foster, DM; Gookin, JL; Stauffer, SH, 2008) |
| "Clinical and biochemical effects of indomethacin were monitored in a patient with congenital chloride diarrhea (CCD) before and after 10 days of therapy." | 7.68 | Effects of indomethacin in congenital chloride diarrhea. ( Mayatepek, E; Nützenadel, W; Seyberth, HW, 1992) |
| " The authors report a patient with hepatocellular carcinoma associated with diarrhea mediated by prostaglandins, surviving 30 months after receiving treatment with indomethacin and Adriamycin." | 7.67 | Long survival of diarrhea-associated hepatocarcinoma treated with Adriamycin and indomethacin. A case report. ( Barcena, R; Boixeda, D; Moreno, A; Saban, J; Serrano-Rios, M, 1986) |
| "In a patient with Shy-Drager syndrome the severe episodic diarrhea and orthostatic hypotension were both successfully treated with indomethacin." | 7.66 | [Successful indomethacin therapy of severe diarrhea with primary orthostatic hypotension]. ( Scheidegger, K; Schlup, P; Straub, PW, 1980) |
| "With indomethacin treatment diurnal rectal fluid production dropped by about 50% and all prostanoids measured in urine and rectal fluid decreased below control values." | 5.28 | Secretory diarrhea in villous adenoma of rectum: effect of treatment with somatostatin and indomethacin. ( Hoekman, K; Keirse, MJ; Meinders, AE; Noort, WA; Smelt, AH, 1992) |
| " After hydroelectrolytic treatment, a PG synthetase inhibitor (indomethacin) was added to a dosage of 25 mg q/d PO." | 5.28 | [Treatment with indomethacin for the control of the metabolic disorder caused by a villous adenoma of the rectum]. ( Batalla Eiras, A; Casal Iglesias, L; Cutrin Prieto, C; Diéguez Gómez, P; Lorenzo Zúniga, V; Meniño Olveira, MJ, 1991) |
| "Indomethacin treatment (24 mg X 4 daily) reduced the rectal PGE2 excretion from 2." | 5.26 | Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. ( Bukhave, K; Lange, P; Rask-Madsen, J; Steven, K, 1981) |
| "A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera." | 5.05 | Indomethacin and chloroquine fail to inhibit fluid loss in cholera. ( Butler, T; Rabbani, GH, 1985) |
| "300 mg/day phenylbutazone, 210 mg/day indomethacin, and 600 mg/day pyrasanone were administered for 14 days to three randomised groups of patients respectively, consisting of a total of 76 subjects with various forms of non-infectious inflammation (osteoarthritis, fibrositis, rheumatoid arthritis, gout, phlebitis), in a double-blind trila designed to determine the activity of the three drugs and their tolerance." | 5.04 | [Evaluation of the effects of some non-steroid anti-inflammatory agents on the gastric mucosa]. ( Bianchi, PA; Polli, EE; Vigo, PL, 1976) |
| " The gastroprotective action of ME was analyzed in gastric ulcers that were induced by ethanol or indomethacin in Wistar male rats." | 3.79 | Effect of menthol in experimentally induced ulcers: pathways of gastroprotection. ( Hiruma-Lima, CA; Padovani, CR; Pellizzon, CH; Rozza, AL; Takahira, RK, 2013) |
| "Results of these studies demonstrate that provision of additional NO substrate in the form of L-arginine incites prostaglandin-dependent secretory diarrhea and does not promote epithelial defense or barrier function of C." | 3.74 | Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. ( Coccaro, MR; Foster, DM; Gookin, JL; Stauffer, SH, 2008) |
| "Clinical and biochemical effects of indomethacin were monitored in a patient with congenital chloride diarrhea (CCD) before and after 10 days of therapy." | 3.68 | Effects of indomethacin in congenital chloride diarrhea. ( Mayatepek, E; Nützenadel, W; Seyberth, HW, 1992) |
| "0 mg/kg) and DMPG (10-40 micrograms/kg) overcame morphine-induced constipation in a dose-related manner, the respective ED50s being 0." | 3.67 | M&B 28,767: a potent anti-secretory and anti-ulcer PG analogue. A comparative study with 16, 16' dimethyl PGE2 methylester. ( Banerjee, AK; Christmas, AJ; Crowshaw, K; Heazell, MA; Ivers-Read, GC; Saunders, LC; Wyatt, D, 1984) |
| " FCE 20700 was more potent than PGE2 in the prevention of stress-induced gastric ulcers (ED50 = 262 and 787 mcg/kg) and indomethacin-induced intestinal ulcers (ED50 = 557 and 4569 mcg/kg), and showed the same potency as PGE2 in the prevention of ethanol (ED50 = 9." | 3.67 | Cytoprotective and antisecretory effects of 11-deoxy-13,14-didehydro-16(s)-methyl PGE2 methylester (FCE 20700). ( Arrigoni, C; Ceserani, R; Faustini, F; Mizzotti, B; Toti, D, 1984) |
| " The authors report a patient with hepatocellular carcinoma associated with diarrhea mediated by prostaglandins, surviving 30 months after receiving treatment with indomethacin and Adriamycin." | 3.67 | Long survival of diarrhea-associated hepatocarcinoma treated with Adriamycin and indomethacin. A case report. ( Barcena, R; Boixeda, D; Moreno, A; Saban, J; Serrano-Rios, M, 1986) |
| " On the other hand, protective effects of PGM on diarrhea induced by arachidonic acid in mice were about 1/2 times as potent as those of IND in both 1 and 4 hr pretreatments." | 3.67 | [Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract]. ( Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y, 1986) |
| "In a patient with Shy-Drager syndrome the severe episodic diarrhea and orthostatic hypotension were both successfully treated with indomethacin." | 3.66 | [Successful indomethacin therapy of severe diarrhea with primary orthostatic hypotension]. ( Scheidegger, K; Schlup, P; Straub, PW, 1980) |
| "Relief of colic was assessed by counting the total number of supplemental narcotics used by each patient per 24 hours during the study period, which was defined as until passage of the calculus or 5 days." | 2.66 | Use of indomethacin suppositories in the prophylaxis of recurrent ureteral colic. ( Gillen, J; Kapoor, DA; Melanson, S; Mowad, JJ; Weitzel, S, 1989) |
| "Upper gastrointestinal haemorrhage and pseudomembranous colitis are potentially fatal manifestations of drug therapy." | 2.36 | Drug-induced gastrointestinal disease. ( Bramble, MG; Record, CO, 1978) |
| "For biotherapeutic agents, there is a lack of information on dose-response relationships and mechanism of action." | 1.32 | Dose-response relationship and mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhea in rats. ( Gillardin, JM; Girard, P; Lorette, I; Pansart, Y, 2003) |
| "Piglet cryptosporidiosis is characterized by intestinal villous damage and malabsorption, and by reduced NaCl absorption in response to prostaglandins (PGs), which act directly on the epithelium and indirectly through enteric nerves." | 1.30 | Reactive oxygen metabolites in piglet cryptosporidiosis. ( Argenzio, RA; Rhoads, JM, 1997) |
| "We tried to produce a new ulcerative colitis model in rats by topical administration of sulfhydryl blockers." | 1.30 | New ulcerative colitis model induced by sulfhydryl blockers in rats and the effects of antiinflammatory drugs on the colitis. ( Sato, F; Satoh, H; Szabo, S; Takami, K, 1997) |
| "With indomethacin treatment diurnal rectal fluid production dropped by about 50% and all prostanoids measured in urine and rectal fluid decreased below control values." | 1.28 | Secretory diarrhea in villous adenoma of rectum: effect of treatment with somatostatin and indomethacin. ( Hoekman, K; Keirse, MJ; Meinders, AE; Noort, WA; Smelt, AH, 1992) |
| " After hydroelectrolytic treatment, a PG synthetase inhibitor (indomethacin) was added to a dosage of 25 mg q/d PO." | 1.28 | [Treatment with indomethacin for the control of the metabolic disorder caused by a villous adenoma of the rectum]. ( Batalla Eiras, A; Casal Iglesias, L; Cutrin Prieto, C; Diéguez Gómez, P; Lorenzo Zúniga, V; Meniño Olveira, MJ, 1991) |
| "Microscopic colitis is responsible for a proportion of cases of intractable diarrhoea of obscure origin and rectal and colonic biopsies sould be undertaken in such cases." | 1.26 | Microscopic colitis-a cause of chronic watery diarrhoea. ( Ball, JA; Dawson, AM; Kingham, JG; Levison, DA, 1982) |
| "Indomethacin treatment (24 mg X 4 daily) reduced the rectal PGE2 excretion from 2." | 1.26 | Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. ( Bukhave, K; Lange, P; Rask-Madsen, J; Steven, K, 1981) |
| "Three cases of Reiter's disease occurring in boys under the age of 16 are reported." | 1.25 | Reiter's disease in three boys. ( Hancock, JA; Iveson, JM; Nanda, BS; Pownall, PJ; Wright, V, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (62.03) | 18.7374 |
| 1990's | 19 (24.05) | 18.2507 |
| 2000's | 7 (8.86) | 29.6817 |
| 2010's | 4 (5.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fahrenholtz, KE | 1 |
| Silverzweig, MZ | 1 |
| Germane, N | 1 |
| Crowley, HJ | 1 |
| Simko, BA | 1 |
| Dalton, C | 1 |
| Rozza, AL | 1 |
| Hiruma-Lima, CA | 1 |
| Takahira, RK | 1 |
| Padovani, CR | 1 |
| Pellizzon, CH | 1 |
| Kon, R | 1 |
| Ikarashi, N | 1 |
| Nagoya, C | 1 |
| Takayama, T | 1 |
| Kusunoki, Y | 1 |
| Ishii, M | 1 |
| Ueda, H | 1 |
| Ochiai, W | 1 |
| Machida, Y | 1 |
| Sugita, K | 1 |
| Sugiyama, K | 1 |
| Kapoor, S | 1 |
| Paviour, DC | 1 |
| Ellis, CM | 1 |
| Jiang, GL | 1 |
| Im, WB | 1 |
| Donde, Y | 1 |
| Wheeler, LA | 1 |
| Robert, J | 1 |
| Nebreda, J | 1 |
| Sanuy, B | 1 |
| Peña, MC | 1 |
| Juan-Creix, A | 1 |
| Charte, A | 1 |
| Girard, P | 1 |
| Pansart, Y | 1 |
| Lorette, I | 1 |
| Gillardin, JM | 1 |
| Blassneck, K | 1 |
| Nusko, G | 1 |
| Niedobitek, G | 1 |
| Hahn, EG | 1 |
| Harsch, IA | 1 |
| Borrás-Blasco, J | 1 |
| Enriquez, R | 1 |
| Sirvent, AE | 1 |
| Amoros, F | 1 |
| Navarro-Ruiz, A | 1 |
| Reyes, A | 1 |
| Gookin, JL | 1 |
| Foster, DM | 1 |
| Coccaro, MR | 1 |
| Stauffer, SH | 1 |
| Beubler, E | 1 |
| Bukhave, K | 6 |
| Rask-Madsen, J | 5 |
| Buisseret, P | 1 |
| Kingham, JG | 1 |
| Levison, DA | 1 |
| Ball, JA | 1 |
| Dawson, AM | 1 |
| Vischer, P | 1 |
| Casals-Stenzel, J | 1 |
| Raychaudhury, A | 1 |
| Agarwal, RK | 1 |
| Sanyal, SC | 1 |
| Burke, V | 1 |
| Gracey, M | 1 |
| Korman, SH | 1 |
| Berant, M | 1 |
| Alon, U | 1 |
| Banerjee, AK | 1 |
| Christmas, AJ | 1 |
| Crowshaw, K | 1 |
| Heazell, MA | 1 |
| Ivers-Read, GC | 1 |
| Saunders, LC | 1 |
| Wyatt, D | 1 |
| Arrigoni, C | 1 |
| Mizzotti, B | 1 |
| Toti, D | 1 |
| Faustini, F | 1 |
| Ceserani, R | 1 |
| Ahrens, FA | 1 |
| Zhu, B | 1 |
| Musch, MW | 1 |
| Miller, RJ | 1 |
| Field, M | 1 |
| Siegel, MI | 1 |
| Neumann, SZ | 1 |
| Gullikson, GW | 1 |
| Sender, M | 1 |
| Bass, P | 1 |
| Usardi, MM | 1 |
| Bossoni, G | 1 |
| Tarantino, P | 1 |
| Steven, K | 1 |
| Lange, P | 1 |
| Doherty, NS | 1 |
| Rampton, DS | 1 |
| Breuer, NF | 1 |
| Vaja, SG | 1 |
| Sladen, GE | 1 |
| Dowling, RH | 1 |
| Schlup, P | 1 |
| Scheidegger, K | 1 |
| Straub, PW | 1 |
| Li, SY | 1 |
| Geng, ZC | 1 |
| Wang, AZ | 1 |
| Gao, YL | 1 |
| Li, M | 1 |
| Wang, HD | 1 |
| Wang, WY | 1 |
| Perkins, WE | 1 |
| Bianchi, RG | 1 |
| Tremont, SJ | 1 |
| Collins, PW | 1 |
| Casler, JJ | 1 |
| Fenton, RL | 1 |
| Wagner, GM | 1 |
| McGrath, MP | 1 |
| Stolzenbach, JC | 1 |
| Kowalski, DL | 1 |
| Yamauchi, K | 3 |
| Yagi, T | 3 |
| Kuwano, S | 3 |
| Rowlands, S | 1 |
| Kasby, C | 1 |
| Poon, C | 1 |
| Murray, H | 1 |
| Schmitz, H | 1 |
| Fromm, M | 1 |
| Bode, H | 1 |
| Scholz, P | 1 |
| Riecken, EO | 1 |
| Schulzke, JD | 1 |
| Argenzio, RA | 1 |
| Rhoads, JM | 1 |
| Satoh, H | 1 |
| Sato, F | 1 |
| Takami, K | 1 |
| Szabo, S | 1 |
| Uchida, M | 1 |
| Matsueda, K | 1 |
| Kato, Y | 1 |
| Shoda, R | 1 |
| Yamato, S | 1 |
| Muraoka, A | 1 |
| Robert, FS | 1 |
| Rao, JP | 1 |
| Kase, Y | 1 |
| Saitoh, K | 1 |
| Makino, B | 1 |
| Hashimoto, K | 1 |
| Ishige, A | 1 |
| Komatsu, Y | 1 |
| Nwafor, PA | 1 |
| Okwuasaba, FK | 1 |
| Nalin, DR | 1 |
| Jaffe, BM | 1 |
| Kopen, DF | 1 |
| DeSchryver-Kecskemeti, K | 1 |
| Gingerich, RL | 1 |
| Greider, M | 1 |
| Ezer, E | 1 |
| Pálosi, E | 1 |
| Hajós, G | 1 |
| Rosdy, B | 1 |
| Szporny, L | 1 |
| Bramble, MG | 1 |
| Record, CO | 1 |
| Elder, MG | 1 |
| Kapadia, L | 1 |
| Dodge, JA | 1 |
| Hamdi, I | 1 |
| Walker, S | 1 |
| Lundström, V | 1 |
| Gréen, K | 1 |
| Wiqvist, N | 1 |
| Muryobayashi, T | 1 |
| Okada, K | 1 |
| Shingae, J | 1 |
| Yellin, TO | 1 |
| Buck, SH | 1 |
| Sperow, JW | 1 |
| Bianchi, PA | 1 |
| Vigo, PL | 1 |
| Polli, EE | 1 |
| Ciccolunghi, SN | 1 |
| Levi, B | 1 |
| Chaudri, HA | 1 |
| Iveson, JM | 1 |
| Nanda, BS | 1 |
| Hancock, JA | 1 |
| Pownall, PJ | 1 |
| Wright, V | 1 |
| Hitotsubashi, S | 1 |
| Fujii, Y | 1 |
| Yamanaka, H | 1 |
| Okamoto, K | 1 |
| Smelt, AH | 1 |
| Meinders, AE | 1 |
| Hoekman, K | 1 |
| Noort, WA | 1 |
| Keirse, MJ | 1 |
| Mayatepek, E | 1 |
| Seyberth, HW | 1 |
| Nützenadel, W | 1 |
| Pons, L | 1 |
| Droy-Lefaix, MT | 1 |
| Braquet, P | 1 |
| Bueno, L | 1 |
| Miyawaki, Y | 2 |
| Nishikawa, A | 1 |
| Bunce, KT | 1 |
| Clayton, NM | 1 |
| Coleman, RA | 1 |
| Collington, EW | 1 |
| Finch, H | 1 |
| Humphray, JM | 1 |
| Humphrey, PP | 1 |
| Reeves, JJ | 1 |
| Sheldrick, RL | 1 |
| Stables, R | 1 |
| Khurana, S | 1 |
| Ganguly, NK | 1 |
| Khullar, M | 1 |
| Panigrahi, D | 1 |
| Walia, BN | 1 |
| Cutrin Prieto, C | 1 |
| Casal Iglesias, L | 1 |
| Batalla Eiras, A | 1 |
| Meniño Olveira, MJ | 1 |
| Diéguez Gómez, P | 1 |
| Lorenzo Zúniga, V | 1 |
| Knauf, H | 1 |
| Haag, K | 1 |
| Lübcke, R | 1 |
| Berger, E | 1 |
| Gerok, W | 1 |
| Kapoor, DA | 1 |
| Weitzel, S | 1 |
| Mowad, JJ | 1 |
| Melanson, S | 1 |
| Gillen, J | 1 |
| Nishikawa, T | 1 |
| Saban, J | 1 |
| Boixeda, D | 1 |
| Moreno, A | 1 |
| Barcena, R | 1 |
| Serrano-Rios, M | 1 |
| Ono, N | 1 |
| Yamasaki, Y | 1 |
| Yamamoto, N | 1 |
| Sunami, A | 1 |
| Miyake, H | 1 |
| Tsurumi, K | 1 |
| Kyuki, K | 1 |
| Niwa, M | 1 |
| Mibu, H | 1 |
| Fujimura, H | 1 |
| Coelho, JC | 1 |
| Gouma, DJ | 1 |
| Li, YF | 1 |
| Moody, FG | 1 |
| Schlegel, JF | 1 |
| Higuchi, S | 1 |
| Shioiri, Y | 1 |
| Tanaka, N | 1 |
| Otomo, S | 1 |
| Aihara, H | 1 |
| Rabbani, GH | 1 |
| Butler, T | 1 |
| Pak, SG | 1 |
| Vinnitskiĭ, LI | 1 |
| Neliubov, MV | 1 |
| Egorova, IA | 1 |
| Lippmann, W | 1 |
| Hahn, KJ | 1 |
| Skarnes, RC | 1 |
| Harper, MJ | 1 |
| Bain, LS | 1 |
| Masheter, HC | 1 |
| Buchmann, E | 1 |
4 reviews available for indomethacin and Diarrhea
| Article | Year |
|---|---|
Drug treatment of allergic gastroenteritis.
Topics: Adult; Allergens; Antibody-Producing Cells; Antidiarrheals; Antigen-Antibody Reactions; Aspirin; Dia | 1980 |
Review: prostaglandins in diarrheal states.
Topics: Aspirin; Bacterial Infections; Child; Cholera Toxin; Colonic Diseases; Cyclic AMP; Diarrhea; Dinopro | 1981 |
Drug-induced gastrointestinal disease.
Topics: Adrenal Cortex Hormones; Cathartics; Colon; Constipation; Diarrhea; Enterocolitis, Pseudomembranous; | 1978 |
Prostaglandin E2 in intestinal secretion with special reference to methodological problems in vivo and in vitro.
Topics: Adenoma; Animals; Cholera; Colonic Diseases, Functional; Diarrhea; Dinoprostone; Dose-Response Relat | 1992 |
10 trials available for indomethacin and Diarrhea
| Article | Year |
|---|---|
Prostaglandin E2 in jejunal fluids and its potential diagnostic value for selecting patients with indomethacin-sensitive diarrhoea.
Topics: Alcoholism; Clinical Trials as Topic; Colonic Diseases, Functional; Diarrhea; Dinoprostone; Double-B | 1981 |
An approach to evaluation of local intestinal PG production and clinical assessment of its inhibition by indomethacin in chronic diarrhea.
Topics: Alcoholism; Chronic Disease; Clinical Trials as Topic; Colonic Diseases, Functional; Diarrhea; Human | 1980 |
Indomethacin in the treatment of primary dysmenorrhoea.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Dysmenorrhea; Fem | 1979 |
[Evaluation of the effects of some non-steroid anti-inflammatory agents on the gastric mucosa].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Diarrhea; Drug Tolerance; Female; Fibromyalgia; Gas | 1976 |
[Clinical experiences with Voltaren a new nonsteroid antirheumatic agent].
Topics: Aniline Compounds; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topi | 1975 |
Use of indomethacin suppositories in the prophylaxis of recurrent ureteral colic.
Topics: Colic; Diarrhea; Emergencies; Female; Humans; Indomethacin; Male; Middle Aged; Prospective Studies; | 1989 |
Indomethacin and chloroquine fail to inhibit fluid loss in cholera.
Topics: Adult; Body Weight; Chloroquine; Cholera; Clinical Trials as Topic; Diarrhea; Female; Fluid Therapy; | 1985 |
A comparison of phenylbutazone and indometacin in the treatment of rheumatoid arthritis.
Topics: Analysis of Variance; Arthritis, Rheumatoid; Clinical Trials as Topic; Diarrhea; Evaluation Studies | 1973 |
Flufenamic acid and indomethacin in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diarrhea; Digestion; Fema | 1966 |
Mefenamic acid compared with indomethacin and placebo in osteoarthritis.
Topics: Anti-Inflammatory Agents; Clinical Trials as Topic; Diarrhea; Digestion; Duodenal Ulcer; Female; Fol | 1966 |
65 other studies available for indomethacin and Diarrhea
| Article | Year |
|---|---|
3-Phenyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]indole-2-carbonitrile, a potent inhibitor of prostaglandin synthetase and of platelet aggregation.
Topics: Animals; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Diarrhea; Humans; In Vitro Technique | 1979 |
Effect of menthol in experimentally induced ulcers: pathways of gastroprotection.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channels; Castor Oil; Cyclic GMP; Diarrhea | 2013 |
Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.
Topics: Animals; Anthracenes; Aquaporin 3; Cell Line; Colon; Colonic Neoplasms; Diarrhea; Dinoprostone; HT29 | 2014 |
Mckittrick-Wheelock syndrome: an often, overlooked complication of rectal adenomas.
Topics: Adenoma, Villous; Cyclooxygenase Inhibitors; Diarrhea; Female; Fluid Therapy; Humans; Indomethacin; | 2014 |
Paroxysmal hemicrania and POEMS syndrome: further evidence that neuropeptides are implicated in primary headache?
Topics: Adult; Angiogenesis Inhibitors; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 2008 |
Comparison of prostaglandin E2 receptor subtype 4 agonist and sulfasalazine in mouse colitis prevention and treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cell Proliferation; Colitis; Colon; D | 2010 |
[Indomethacin-induced diarrhea].
Topics: Diarrhea; Female; Humans; Indomethacin; Middle Aged | 2002 |
Dose-response relationship and mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhea in rats.
Topics: Animals; Antidiarrheals; Arginine; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Fungal Va | 2003 |
[Chronic diarrhea caused by NSAIDs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Colitis; Collagen; Colonoscopy; D | 2004 |
Acute renal failure associated with an accidental overdose of colchicine.
Topics: Acute Kidney Injury; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty | 2005 |
Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets.
Topics: Alanine; Analysis of Variance; Animals; Animals, Newborn; Arginine; Atrophy; Chlorides; Cryptosporid | 2008 |
Colonic secretion mediated by prostaglandin E2 and 5-hydroxytryptamine may contribute to diarrhea due to morphine withdrawal in the rat.
Topics: Animals; Atropine; Clonidine; Colon; Cyclic AMP; Diarrhea; Dinoprostone; Female; Humans; Indomethaci | 1984 |
Microscopic colitis-a cause of chronic watery diarrhoea.
Topics: Adult; Chronic Disease; Colitis; Colon; Diarrhea; Female; Humans; Indomethacin; Male; Middle Aged; P | 1982 |
Influence of prostacyclin and indomethacin on castor oil-induced gastrointestinal effects in rats.
Topics: Animals; Body Fluids; Castor Oil; Diarrhea; Epoprostenol; Gastrointestinal Motility; Indomethacin; M | 1983 |
Enteropathogenicity of Klebsiella pneumoniae strains isolated from stools of diarrhoeal patients and other clinical specimens: an experimental study.
Topics: Animals; Bacteriological Techniques; Child; Chlorpromazine; Diarrhea; Dibenz(b,f)(1,4)oxazepine-10(1 | 1984 |
Studies with enterotoxigenic microorganisms: effects of candidate antidiarrhoeals in experimental animals in vivo.
Topics: Aluminum Hydroxide; Animals; Antidiarrheals; Aspirin; Bacterial Infections; Charcoal; Chlorpromazine | 1984 |
M&B 28,767: a potent anti-secretory and anti-ulcer PG analogue. A comparative study with 16, 16' dimethyl PGE2 methylester.
Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Constipation; Diarrhea; Gastric Acid; Gastroin | 1984 |
Cytoprotective and antisecretory effects of 11-deoxy-13,14-didehydro-16(s)-methyl PGE2 methylester (FCE 20700).
Topics: Animals; Anti-Ulcer Agents; Diarrhea; Dinoprostone; Ethanol; Gastric Juice; Indomethacin; Intestines | 1984 |
Effects of indomethacin, acetazolamide, ethacrynate sodium, and atropine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in pig jejunum.
Topics: Acetazolamide; Animals; Atropine; Diarrhea; Enterotoxins; Escherichia coli; Ethacrynic Acid; Indomet | 1982 |
Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid.
Topics: Animals; Arachidonic Acids; Bicarbonates; Chlorides; Colitis; Colon; Diarrhea; Hydroxyeicosatetraeno | 1982 |
Childhood diarrhoea and its treatment with indomethacin in Libya.
Topics: Animals; Child; Child, Preschool; Dehydration; Diarrhea; Diarrhea, Infantile; Fluid Therapy; Glycine | 1980 |
Laxative-like effects of nonsteroidal anti-inflammatory drugs on intestinal fluid movement and membrane integrity.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents; Aspirin; Body Fluids; Cathartics; Cricetinae; Diarrh | 1982 |
Inhibition of prostaglandin synthesis by zidometacin.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Diarrhea; Female; Gastric Mucosa; In Vitro Tec | 1981 |
Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin.
Topics: Adenoma; Diarrhea; Humans; Indomethacin; Male; Middle Aged; Prostaglandins E; Rectal Neoplasms | 1981 |
Inhibition of arachidonic acid release as the mechanism by which glucocorticoids inhibit endotoxin-induced diarrhoea.
Topics: Animals; Arachidonic Acids; Codeine; Dexamethasone; Diarrhea; Endotoxins; Female; Glucocorticoids; I | 1981 |
Role of prostaglandins in bile salt-induced changes in rat colonic structure and function.
Topics: Animals; Bile Acids and Salts; Colon; Deoxycholic Acid; Diarrhea; Female; Indomethacin; Intestinal M | 1981 |
[Successful indomethacin therapy of severe diarrhea with primary orthostatic hypotension].
Topics: Aged; Diarrhea; Humans; Hypotension, Orthostatic; Indomethacin; Male; Prostatectomy; Urinary Inconti | 1980 |
The relationship between PGE2 level in mothers' milk and physiological diarrhea of the baby and the treatment.
Topics: Adult; Breast Feeding; Diarrhea; Dinoprostone; Female; Humans; Indomethacin; Infant, Newborn; Male; | 1994 |
Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem.
Topics: Animals; Antacids; Aspirin; Biological Availability; Butadienes; Depression, Chemical; Diarrhea; Dog | 1994 |
Suppression of the purgative action of rhein anthrone, the active metabolite of sennosides A and B, by calcium channel blockers, calmodulin antagonists and indomethacin.
Topics: Animals; Anthracenes; Anthraquinones; Calcium; Calcium Channel Blockers; Calmodulin; Cathartics; Col | 1993 |
Antenatal ultrasound diagnosis of dilated fetal bowel due to congenital chloride diarrhoea.
Topics: Adult; Chlorides; Diarrhea; Dilatation, Pathologic; Feces; Female; Humans; Indomethacin; Intestines; | 1996 |
Tumor necrosis factor-alpha induces Cl- and K+ secretion in human distal colon driven by prostaglandin E2.
Topics: Biological Transport; Cell Line; Chlorides; Colon; Cyclooxygenase Inhibitors; Diarrhea; Dinoprostone | 1996 |
Reactive oxygen metabolites in piglet cryptosporidiosis.
Topics: Animals; Animals, Newborn; Biological Transport; Catalase; Cryptosporidiosis; Diarrhea; Electrolytes | 1997 |
New ulcerative colitis model induced by sulfhydryl blockers in rats and the effects of antiinflammatory drugs on the colitis.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Colitis, | 1997 |
[Involvement of nitric oxide, which was synthesized by constitutive nitric oxide synthase, and prostaglandin on diarrhea induced by castor oil in rats].
Topics: Animals; Castor Oil; Cathartics; Dexamethasone; Diarrhea; Guanidines; Indomethacin; Male; NG-Nitroar | 1997 |
Mechanism of purgative effect of magnesium sulphate on mouse colon.
Topics: Animals; Anthracenes; Cathartics; Chloride Channels; Colon; Diarrhea; Disease Models, Animal; Drug I | 1997 |
Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components.
Topics: Animals; Antidiarrheals; Castor Oil; Corticosterone; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; | 1999 |
Effect of methanolic extract of Cassia nigricans leaves on rat gastrointestinal tract.
Topics: Animals; Anti-Ulcer Agents; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Ethanol; Gastroi | 2001 |
Testing for cholera antagonists.
Topics: Adult; Animals; Antitoxins; Cholera; Diarrhea; Dogs; Drug Evaluation, Preclinical; Humans; Indometha | 1977 |
Indomethacin-responsive pancreatic cholera.
Topics: Adenoma, Islet Cell; Aged; Dehydration; Diarrhea; Female; Gastrins; Humans; Hypercalcemia; Hypokalem | 1977 |
Prostaglandins and chronic diarrhoea: methodological problems.
Topics: Animals; Arachidonic Acids; Chromatography, Gas; Chromatography, Thin Layer; Chronic Disease; Diarrh | 1979 |
Comparative pharmacology of a 1:10 combination of indomethacin-sodium salicylate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Castor Oil; Diarrhea; Ede | 1979 |
Prostaglandin-induced diarrhoea.
Topics: Aspirin; Child, Preschool; Diarrhea; Female; Humans; Indomethacin; Prostaglandins | 1977 |
Prostaglandins, indomethacin and dysmenorrhea.
Topics: Diarrhea; Dysmenorrhea; Female; Humans; Indomethacin; Menstruation; Nausea; Prostaglandins F; Uterin | 1976 |
Effects of new synthetic analogues of prostaglandin E2 on gastric acid secretion and gastric ulceration.
Topics: Animals; Diarrhea; Dogs; Gastric Mucosa; Humans; Indomethacin; Male; Pentagastrin; Prostaglandins E; | 1976 |
Inhibition of the diarrheal and cardiac actions of arachidonic acid by fenclorac, a new anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Diarrhea; Dose-Response Relationship, Drug; Ed | 1976 |
Reiter's disease in three boys.
Topics: Adolescent; Arthritis; Arthritis, Reactive; Diarrhea; Humans; Indomethacin; Male; Phenylbutazone; Sa | 1975 |
Some properties of purified Escherichia coli heat-stable enterotoxin II.
Topics: Animals; Aspirin; Bacterial Toxins; Biological Assay; Cholera Toxin; Diarrhea; Dinoprostone; Enterot | 1992 |
Secretory diarrhea in villous adenoma of rectum: effect of treatment with somatostatin and indomethacin.
Topics: Adenoma; Aged; Body Fluids; Diarrhea; Electrolytes; Humans; Indomethacin; Male; Octreotide; Prostagl | 1992 |
Effects of indomethacin in congenital chloride diarrhea.
Topics: 18-Hydroxycorticosterone; Aldosterone; Chlorine; Diarrhea; Dinoprost; Dinoprostone; Humans; Indometh | 1992 |
Role of free radicals and platelet-activating factor in the genesis of intestinal motor disturbances induced by Escherichia coli endotoxins in rats.
Topics: Animals; Diarrhea; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; | 1991 |
Suppression of the purgative action of rhein anthrone, the active metabolite of sennosides A and B, by indomethacin in rats.
Topics: Animals; Anthracenes; Anthraquinones; Cathartics; Colon; Diarrhea; Dinoprostone; Electrolytes; Femal | 1991 |
GR63799X--a novel prostanoid with selectivity for EP3 receptors.
Topics: Alprostadil; Animals; Cats; Diarrhea; Dinoprostone; Dogs; Enprostil; Ethanol; Female; Gastric Acid; | 1991 |
Studies on the mechanism of Salmonella typhimurium enterotoxin-induced diarrhoea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcimycin; Calcium; Chlor | 1991 |
[Treatment with indomethacin for the control of the metabolic disorder caused by a villous adenoma of the rectum].
Topics: Adenoma; Aged; Diarrhea; Female; Humans; Indomethacin; Rectal Neoplasms; Water-Electrolyte Imbalance | 1991 |
[Substance transport in the colon and its pharmacologic modification].
Topics: Acid-Base Equilibrium; Amiloride; Animals; Carrier Proteins; Colon; Diarrhea; Humans; Hyperaldostero | 1986 |
Involvement of prostaglandin E-like material in the purgative action of rhein anthrone, the intraluminal active metabolite of sennosides A and B in mice.
Topics: Animals; Anthraquinones; Barium Sulfate; Cathartics; Diarrhea; Dibenz(b,f)(1,4)oxazepine-10(11H)-car | 1988 |
Long survival of diarrhea-associated hepatocarcinoma treated with Adriamycin and indomethacin. A case report.
Topics: Adult; Carcinoma, Hepatocellular; Diarrhea; Doxorubicin; Drug Therapy, Combination; Humans; Indometh | 1986 |
[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidoni | 1986 |
Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid. 2nd communication: inhibitory effects on acute inflammation and prostaglandin-related reactions.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Benzopyrans; Benzothiepins; | 1986 |
Effect of 16,16-dimethyl prostaglandin E2 on the myoelectric activity of the gastrointestinal tract of the opossum.
Topics: 16,16-Dimethylprostaglandin E2; Action Potentials; Animals; Diarrhea; Digestive System Physiological | 1986 |
[The modes of anti-inflammatory and analgesic actions of 2-[4-(3-methyl-2-butenyl) phenyl] propionic acid (TA-60) and 2-[4-(2,2-dichlorovinyl) phenyl] propionic acid (TA-668) and effect of TA-60 on the gastrointestinal tract].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Diarrhea | 1985 |
[Renin-angiotensin-aldosterone system and water-electrolyte metabolism in salmonellosis].
Topics: Adolescent; Adult; Combined Modality Therapy; Diarrhea; Fluid Therapy; Humans; Indomethacin; Middle | 1985 |
Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids.
Topics: Administration, Oral; Animals; Depression, Chemical; Diarrhea; Fatty Acids, Unsaturated; Female; Gas | 1974 |
Relationship between endotoxin-induced abortion and the synthesis of prostaglandin F.
Topics: Abortion, Induced; Animals; Diarrhea; Dose-Response Relationship, Drug; Drug Interactions; Endotoxin | 1972 |