indomethacin has been researched along with Diabetes Mellitus in 17 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice." | 7.66 | Indomethacin- and Moduretic--induced hyperkalemia. ( Mor, R; Pitlik, S; Rosenfeld, JB, 1983) |
| "We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin." | 7.66 | Indomethacin-induced hyperkalemia in three patients with gouty arthritis. ( Beckstrom, D; Findling, JW; Itskovitz, H; Kozin, F; Rawsthorne, L, 1980) |
| " Magnesium sulfate administration, steroid administration, maternal diabetes mellitus, gestational age at delivery, indomethacin exposure, birthweight, and chorioamnionitis were all considered as possible covariates in the multivariable regression models." | 3.83 | Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes. ( DeWitt, PE; Faucett, AM; Gibbs, RS; Metz, TD, 2016) |
| "Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice." | 3.66 | Indomethacin- and Moduretic--induced hyperkalemia. ( Mor, R; Pitlik, S; Rosenfeld, JB, 1983) |
| "We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin." | 3.66 | Indomethacin-induced hyperkalemia in three patients with gouty arthritis. ( Beckstrom, D; Findling, JW; Itskovitz, H; Kozin, F; Rawsthorne, L, 1980) |
| " The dose-response curve for the acetylcholine-induced relaxation was slightly, but significantly attenuated in diabetic mice." | 1.31 | Contractile responses in spontaneously diabetic mice. I. Involvement of superoxide anion in enhanced contractile response of aorta to norepinephrine in C57BL/KsJ(db/db) mice. ( Kamata, K; Kanie, N, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (82.35) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faucett, AM | 1 |
| Metz, TD | 1 |
| DeWitt, PE | 1 |
| Gibbs, RS | 1 |
| Yeo, JL | 1 |
| Tan, BT | 1 |
| Achike, FI | 1 |
| Barnett, AH | 2 |
| Spiliopoulos, AJ | 2 |
| Pyke, DA | 2 |
| de Boer, AC | 1 |
| Genton, E | 1 |
| Turpie, AG | 1 |
| Cruaud, D | 1 |
| Slater, LM | 1 |
| Murray, SL | 1 |
| Kershnar, A | 1 |
| Mosier, MA | 1 |
| Watanabe, J | 1 |
| Umeda, F | 1 |
| Wasada, T | 1 |
| Ibayashi, H | 1 |
| Vesterqvist, O | 1 |
| Gréen, K | 1 |
| Rogers, SP | 1 |
| Larkins, RG | 1 |
| Mor, R | 1 |
| Pitlik, S | 1 |
| Rosenfeld, JB | 1 |
| Bleskin, BI | 1 |
| Asauliuk, IK | 1 |
| Fominov, AT | 1 |
| Koullapis, EN | 1 |
| Nicolaides, K | 1 |
| Giugliano, D | 1 |
| Torella, R | 1 |
| D'Onofrio, F | 1 |
| Luyckx, AS | 1 |
| Mendoza, E | 1 |
| Lefebvre, PJ | 1 |
| Findling, JW | 1 |
| Beckstrom, D | 1 |
| Rawsthorne, L | 1 |
| Kozin, F | 1 |
| Itskovitz, H | 1 |
| Kanie, N | 1 |
| Kamata, K | 1 |
| Waitzman, MB | 1 |
| Rudman, D | 1 |
2 reviews available for indomethacin and Diabetes Mellitus
| Article | Year |
|---|---|
Chemistry, measurement, and clinical significance of platelet specific proteins.
Topics: Aspirin; Beta-Globulins; beta-Thromboglobulin; Blood Coagulation; Blood Coagulation Factors; Blood P | 1982 |
Prostaglandins and the alpha-cell.
Topics: Albuterol; Animals; Arginine; Aspirin; Blood Glucose; Diabetes Mellitus; Furosemide; Glucagon; Guine | 1981 |
15 other studies available for indomethacin and Diabetes Mellitus
| Article | Year |
|---|---|
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Birth Weight; Case-Control Studies; Cerebral Hemorrhage; | 2016 |
Exploring the mechanism of endothelial involvement in acidosis-induced vasodilatation of aortic tissues from normal and diabetic rats.
Topics: 4-Aminopyridine; Acidosis; Animals; Aorta; Barium Compounds; Chlorides; Diabetes Mellitus; Endotheli | 2010 |
Blockade of chlorpropamide-alcohol flushing by indomethacin suggests an association between prostaglandins and diabetic vascular complications.
Topics: Blood Vessels; Chlorpropamide; Diabetes Mellitus; Diabetic Angiopathies; Ethanol; Face; Female; Huma | 1980 |
[Use of indomethacin in the treatment of orthostatic hypotension in diabetic patients].
Topics: Diabetes Mellitus; Humans; Hypotension, Orthostatic; Indomethacin | 1983 |
Immunological suppressor cell activity in insulin dependent diabetes.
Topics: Adult; Autoantibodies; Concanavalin A; Diabetes Mellitus; HLA Antigens; Humans; Indomethacin; Lympho | 1980 |
Effect of prostaglandin synthetase inhibitors on platelet aggregation and thromboxane production in diabetes mellitus.
Topics: Adult; Diabetes Mellitus; Diabetic Retinopathy; Female; Humans; Imidazoles; Indomethacin; Male; Midd | 1984 |
Urinary excretion of 2,3-dinor-thromboxane B2 in man under normal conditions, following drugs and during some pathological conditions.
Topics: Acetaminophen; Adult; Amino Acid Metabolism, Inborn Errors; Aspirin; Circadian Rhythm; Diabetes Mell | 1984 |
Production of 6-oxo-prostaglandin F1 alpha and prostaglandin E2 by isolated glomeruli from normal and diabetic rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Diabete | 1982 |
Indomethacin- and Moduretic--induced hyperkalemia.
Topics: Aged; Amiloride; Diabetes Complications; Diabetes Mellitus; Drug Combinations; Drug Interactions; Fe | 1983 |
[Use of anti-inflammatory therapy in diabetes mellitus].
Topics: Adult; Diabetes Mellitus; Humans; Indomethacin; Male; Phenylbutazone | 1983 |
Circulating prostanoid levels, both basal and during the chlorpropamide alcohol flush, in non-insulin dependent diabetes.
Topics: 6-Ketoprostaglandin F1 alpha; Alcoholic Beverages; Chlorpropamide; Diabetes Mellitus; Face; Female; | 1981 |
Failure of indomethacin to affect arginine-induced C-peptide and glucagon release in insulin-treated diabetics. Major role of residual B cell function in conditioning the magnitude of the blood glucose rise after intravenous arginine.
Topics: Adult; Arginine; Blood Glucose; C-Peptide; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Gl | 1981 |
Indomethacin-induced hyperkalemia in three patients with gouty arthritis.
Topics: Acute Disease; Acute Kidney Injury; Aged; Diabetes Mellitus; Female; Gout; Humans; Hyperkalemia; Ind | 1980 |
Contractile responses in spontaneously diabetic mice. I. Involvement of superoxide anion in enhanced contractile response of aorta to norepinephrine in C57BL/KsJ(db/db) mice.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Blood Glucose; Bod | 2000 |
Prostaglandins in blood of diabetic versus non-diabetic humans.
Topics: Diabetes Mellitus; Female; Humans; Indomethacin; Male; Middle Aged; Prostaglandins; Prostaglandins E | 1978 |