indomethacin has been researched along with Diabetes Mellitus, Type 2 in 21 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The protective effects of telmisartan, the angiotensin II-receptor antagonist, were investigated in rats with type 2 diabetes mellitus exposed to acute gastric ulceration." | 7.76 | Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. ( Al-Sultan, AI; Fouad, AA; Gomaa, W; Yacoubi, MT, 2010) |
| "Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e." | 5.36 | Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010) |
| " Based on previous studies demonstrating the important antioxidant and anti-hyperlipidemic effect of morpholine and 1,4-benzo(x/thi)azine derivatives (A-E), we hereby present the design, synthesis and pharmacological evaluation of novel dual-acting molecules as a therapeutic approach for atherosclerosis." | 3.85 | Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity. ( Katselou, MG; Kourounakis, AP; Matralis, AN, 2017) |
| "The protective effects of telmisartan, the angiotensin II-receptor antagonist, were investigated in rats with type 2 diabetes mellitus exposed to acute gastric ulceration." | 3.76 | Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. ( Al-Sultan, AI; Fouad, AA; Gomaa, W; Yacoubi, MT, 2010) |
| "The functional hemodynamic parameter mean flow velocity (MFV) was assessed at rest, before and 90min after 100mg of INDO, and during the BHT." | 2.78 | Effect of indomethacin on cerebrovascular reactivity in patients with type 2 diabetes mellitus. ( Demarin, V; Drenjancevic, I; Rahelic, D; Vuletic, V, 2013) |
| "Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e." | 1.36 | Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010) |
| "Since type 2 diabetes impairs endothelial sensitivity to flow and increases oxidative stress, we hypothesized that flow-induced remodelling in RAs would be impaired in diabetes." | 1.35 | Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow. ( Belin de Chantemèle, EJ; Guihot, AL; Henrion, D; Loufrani, L; Maquignau, M; Toutain, B; Vessières, E, 2009) |
| " When treating Bartter's syndrome, it is also prudent to remember that the long-term use of nonsteroidal anti-inflammatory drugs and potassium-sparing diuretics may result in serious adverse reactions." | 1.35 | Bartter's syndrome with type 2 diabetes mellitus. ( Lee, SP; See, TT, 2009) |
| " The dosage of 230 mg/kg of nicotinamide given intraperitoneally 15 min before STZ administration (65 mg/kg i." | 1.32 | Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats. ( Kamata, K; Kobayashi, T; Matsumoto, T; Wakabayashi, K, 2004) |
| "These data indicate that NIDDM is associated with increased plasma lipid peroxidation." | 1.29 | Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus. ( Anggård, EE; Betteridge, DJ; Gopaul, NK; Mallet, AI; Nourooz-Zadeh, J; Wolff, SP, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (19.05) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Katselou, MG | 1 |
| Matralis, AN | 1 |
| Kourounakis, AP | 1 |
| Vuletic, V | 1 |
| Drenjancevic, I | 1 |
| Rahelic, D | 1 |
| Demarin, V | 1 |
| Belin de Chantemèle, EJ | 1 |
| Vessières, E | 1 |
| Guihot, AL | 1 |
| Toutain, B | 1 |
| Maquignau, M | 1 |
| Loufrani, L | 1 |
| Henrion, D | 1 |
| See, TT | 1 |
| Lee, SP | 1 |
| Matsumoto, T | 2 |
| Ishida, K | 1 |
| Taguchi, K | 1 |
| Kobayashi, T | 2 |
| Kamata, K | 2 |
| Morsy, MA | 1 |
| Ashour, OM | 1 |
| Fouad, AA | 2 |
| Abdel-Gaber, SA | 1 |
| Al-Sultan, AI | 1 |
| Yacoubi, MT | 1 |
| Gomaa, W | 1 |
| Coppey, LJ | 1 |
| Gellett, JS | 1 |
| Yorek, MA | 1 |
| Ellis, A | 1 |
| Pannirselvam, M | 1 |
| Anderson, TJ | 1 |
| Triggle, CR | 1 |
| Wakabayashi, K | 1 |
| Rastelli, VM | 1 |
| Oliveira, MA | 1 |
| dos Santos, R | 1 |
| de Cássia Tostes Passaglia, R | 1 |
| Nigro, D | 1 |
| de Carvalho, MH | 1 |
| Fortes, ZB | 1 |
| Johnston, C | 2 |
| Wiles, PG | 1 |
| Medbak, S | 1 |
| Bowcock, S | 1 |
| Cooke, ED | 1 |
| Pyke, DA | 1 |
| Rees, LH | 1 |
| Carey, F | 1 |
| Forder, RA | 1 |
| Haworth, D | 1 |
| Gopaul, NK | 1 |
| Anggård, EE | 1 |
| Mallet, AI | 1 |
| Betteridge, DJ | 1 |
| Wolff, SP | 1 |
| Nourooz-Zadeh, J | 1 |
| Hicks, RC | 1 |
| Moss, J | 1 |
| Higman, DJ | 1 |
| Greenhalgh, RM | 1 |
| Powell, JT | 1 |
| Chan, NN | 1 |
| Fauvel, NJ | 1 |
| Feher, MD | 1 |
| Pereira Arias, AM | 2 |
| Romijn, JA | 2 |
| Corssmit, EP | 1 |
| Ackermans, MT | 2 |
| Nijpels, G | 1 |
| Endert, E | 2 |
| Sauerwein, HP | 2 |
| Kagota, S | 1 |
| Yamaguchi, Y | 1 |
| Nakamura, K | 1 |
| Kunitomo, M | 1 |
| Bisschop, PH | 1 |
| Tourniaire, J | 1 |
| Bajard, L | 1 |
| Harfouch, M | 1 |
| Rebattu, B | 1 |
| Garrel, D | 1 |
| Bratusch-Marrain, PR | 1 |
| Vierhapper, H | 1 |
| Komjati, M | 1 |
| Waldhäusl, WK | 1 |
4 trials available for indomethacin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Effect of indomethacin on cerebrovascular reactivity in patients with type 2 diabetes mellitus.
Topics: Adolescent; Adult; Aged; Brain; Cardiovascular Agents; Cerebrovascular Circulation; Diabetes Mellitu | 2013 |
Prostacyclin and thromboxane in non-insulin dependent diabetes: the chlorpropamide alcohol flush reaction revisited.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Female; Flu | 1984 |
Indomethacin decreases insulin secretion in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Cytokines; Diabetes Mellitus, Type 2; Female; Glucose; Hormones; Humans; | 2000 |
Indomethacin does not affect endogenous glucose production in type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Blood Glucose; C-Reactive Protein; Cross-Over Studies; Cyclooxygenase Inhib | 2001 |
17 other studies available for indomethacin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
Topics: Animals; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Disease Mod | 2017 |
Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow.
Topics: Acetylcholine; Adaptation, Physiological; Animals; Antioxidants; Caveolin 1; Cyclic N-Oxides; Diabet | 2009 |
Bartter's syndrome with type 2 diabetes mellitus.
Topics: Adult; Bartter Syndrome; Celecoxib; Diabetes Mellitus, Type 2; Female; Humans; Indomethacin; Pyrazol | 2009 |
Mechanisms underlying enhanced vasorelaxant response to protease-activated receptor 2-activating peptide in type 2 diabetic Goto-Kakizaki rat mesenteric artery.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 2; Dose-Response Relation | 2009 |
Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dinoprostone; Gastric | 2010 |
Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Benzoates; Blood Glu | 2010 |
Mediation of vascular relaxation in epineurial arterioles of the sciatic nerve: effect of diabetes in type 1 and type 2 diabetic rat models.
Topics: Acetylcholine; Animals; Arterioles; Biological Factors; Diabetes Mellitus, Experimental; Diabetes Me | 2003 |
Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Cardiovascular Agents; Catalase; Charybdotoxin; Dia | 2003 |
Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Biological Factors; Chlorides; Diabetes Mellitus, Experimen | 2004 |
Lack of potentiation of bradykinin by angiotensin-(1-7) in a type 2 diabetes model: role of insulin.
Topics: Angiotensin I; Animals; Animals, Newborn; Blood Glucose; Bradykinin; Diabetes Mellitus, Type 2; Drug | 2007 |
The role of endogenous opioids in the chlorpropamide alcohol flush.
Topics: Administration, Oral; Adult; Aged; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Interactions; Enk | 1984 |
Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus.
Topics: Adult; Aspirin; Chromatography, Gas; Diabetes Mellitus, Type 2; Dinoprost; Esterification; Humans; I | 1995 |
The influence of diabetes on the vasomotor responses of saphenous vein and the development of infra-inguinal vein graft stenosis.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Blood Vessel Prosthesis; Bradykinin; Calcimycin; Coll | 1997 |
Non-steroidal anti-inflammatory drugs and metformin: a cause for concern?
Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Diabetes | 1998 |
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus.
Topics: Acetylcholine; Animals; Aorta; Biological Factors; Blood Glucose; Body Weight; Cardiovascular Agents | 2000 |
[Restoration of insulin sensitivity after correction of hypokalemia due to chronic tubulopathy in a diabetic patient].
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glucose Clamp Technique; Humans; H | 1988 |
Acetyl-salicylic acid impairs insulin-mediated glucose utilization and reduces insulin clearance in healthy and non-insulin-dependent diabetic man.
Topics: Adult; Aspirin; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; | 1985 |