Page last updated: 2024-10-29

indomethacin and Diabetes Mellitus, Type 2

indomethacin has been researched along with Diabetes Mellitus, Type 2 in 21 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Research Excerpts

ExcerptRelevanceReference
"The protective effects of telmisartan, the angiotensin II-receptor antagonist, were investigated in rats with type 2 diabetes mellitus exposed to acute gastric ulceration."7.76Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. ( Al-Sultan, AI; Fouad, AA; Gomaa, W; Yacoubi, MT, 2010)
"Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e."5.36Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010)
" Based on previous studies demonstrating the important antioxidant and anti-hyperlipidemic effect of morpholine and 1,4-benzo(x/thi)azine derivatives (A-E), we hereby present the design, synthesis and pharmacological evaluation of novel dual-acting molecules as a therapeutic approach for atherosclerosis."3.85Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity. ( Katselou, MG; Kourounakis, AP; Matralis, AN, 2017)
"The protective effects of telmisartan, the angiotensin II-receptor antagonist, were investigated in rats with type 2 diabetes mellitus exposed to acute gastric ulceration."3.76Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration. ( Al-Sultan, AI; Fouad, AA; Gomaa, W; Yacoubi, MT, 2010)
"The functional hemodynamic parameter mean flow velocity (MFV) was assessed at rest, before and 90min after 100mg of INDO, and during the BHT."2.78Effect of indomethacin on cerebrovascular reactivity in patients with type 2 diabetes mellitus. ( Demarin, V; Drenjancevic, I; Rahelic, D; Vuletic, V, 2013)
"Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e."1.36Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010)
"Since type 2 diabetes impairs endothelial sensitivity to flow and increases oxidative stress, we hypothesized that flow-induced remodelling in RAs would be impaired in diabetes."1.35Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow. ( Belin de Chantemèle, EJ; Guihot, AL; Henrion, D; Loufrani, L; Maquignau, M; Toutain, B; Vessières, E, 2009)
" When treating Bartter's syndrome, it is also prudent to remember that the long-term use of nonsteroidal anti-inflammatory drugs and potassium-sparing diuretics may result in serious adverse reactions."1.35Bartter's syndrome with type 2 diabetes mellitus. ( Lee, SP; See, TT, 2009)
" The dosage of 230 mg/kg of nicotinamide given intraperitoneally 15 min before STZ administration (65 mg/kg i."1.32Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats. ( Kamata, K; Kobayashi, T; Matsumoto, T; Wakabayashi, K, 2004)
"These data indicate that NIDDM is associated with increased plasma lipid peroxidation."1.29Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus. ( Anggård, EE; Betteridge, DJ; Gopaul, NK; Mallet, AI; Nourooz-Zadeh, J; Wolff, SP, 1995)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19904 (19.05)18.7374
1990's3 (14.29)18.2507
2000's10 (47.62)29.6817
2010's4 (19.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Katselou, MG1
Matralis, AN1
Kourounakis, AP1
Vuletic, V1
Drenjancevic, I1
Rahelic, D1
Demarin, V1
Belin de Chantemèle, EJ1
Vessières, E1
Guihot, AL1
Toutain, B1
Maquignau, M1
Loufrani, L1
Henrion, D1
See, TT1
Lee, SP1
Matsumoto, T2
Ishida, K1
Taguchi, K1
Kobayashi, T2
Kamata, K2
Morsy, MA1
Ashour, OM1
Fouad, AA2
Abdel-Gaber, SA1
Al-Sultan, AI1
Yacoubi, MT1
Gomaa, W1
Coppey, LJ1
Gellett, JS1
Yorek, MA1
Ellis, A1
Pannirselvam, M1
Anderson, TJ1
Triggle, CR1
Wakabayashi, K1
Rastelli, VM1
Oliveira, MA1
dos Santos, R1
de Cássia Tostes Passaglia, R1
Nigro, D1
de Carvalho, MH1
Fortes, ZB1
Johnston, C2
Wiles, PG1
Medbak, S1
Bowcock, S1
Cooke, ED1
Pyke, DA1
Rees, LH1
Carey, F1
Forder, RA1
Haworth, D1
Gopaul, NK1
Anggård, EE1
Mallet, AI1
Betteridge, DJ1
Wolff, SP1
Nourooz-Zadeh, J1
Hicks, RC1
Moss, J1
Higman, DJ1
Greenhalgh, RM1
Powell, JT1
Chan, NN1
Fauvel, NJ1
Feher, MD1
Pereira Arias, AM2
Romijn, JA2
Corssmit, EP1
Ackermans, MT2
Nijpels, G1
Endert, E2
Sauerwein, HP2
Kagota, S1
Yamaguchi, Y1
Nakamura, K1
Kunitomo, M1
Bisschop, PH1
Tourniaire, J1
Bajard, L1
Harfouch, M1
Rebattu, B1
Garrel, D1
Bratusch-Marrain, PR1
Vierhapper, H1
Komjati, M1
Waldhäusl, WK1

Trials

4 trials available for indomethacin and Diabetes Mellitus, Type 2

ArticleYear
Effect of indomethacin on cerebrovascular reactivity in patients with type 2 diabetes mellitus.
    Diabetes research and clinical practice, 2013, Volume: 101, Issue:1

    Topics: Adolescent; Adult; Aged; Brain; Cardiovascular Agents; Cerebrovascular Circulation; Diabetes Mellitu

2013
Prostacyclin and thromboxane in non-insulin dependent diabetes: the chlorpropamide alcohol flush reaction revisited.
    Clinical science (London, England : 1979), 1984, Volume: 67, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Female; Flu

1984
Indomethacin decreases insulin secretion in patients with type 2 diabetes mellitus.
    Metabolism: clinical and experimental, 2000, Volume: 49, Issue:7

    Topics: Adult; Aged; Blood Glucose; Cytokines; Diabetes Mellitus, Type 2; Female; Glucose; Hormones; Humans;

2000
Indomethacin does not affect endogenous glucose production in type 2 diabetes mellitus.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2001, Volume: 33, Issue:11

    Topics: Aged; Aged, 80 and over; Blood Glucose; C-Reactive Protein; Cross-Over Studies; Cyclooxygenase Inhib

2001

Other Studies

17 other studies available for indomethacin and Diabetes Mellitus, Type 2

ArticleYear
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Animals; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Disease Mod

2017
Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow.
    Cardiovascular research, 2009, Mar-01, Volume: 81, Issue:4

    Topics: Acetylcholine; Adaptation, Physiological; Animals; Antioxidants; Caveolin 1; Cyclic N-Oxides; Diabet

2009
Bartter's syndrome with type 2 diabetes mellitus.
    Journal of the Chinese Medical Association : JCMA, 2009, Volume: 72, Issue:2

    Topics: Adult; Bartter Syndrome; Celecoxib; Diabetes Mellitus, Type 2; Female; Humans; Indomethacin; Pyrazol

2009
Mechanisms underlying enhanced vasorelaxant response to protease-activated receptor 2-activating peptide in type 2 diabetic Goto-Kakizaki rat mesenteric artery.
    Peptides, 2009, Volume: 30, Issue:9

    Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 2; Dose-Response Relation

2009
Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats.
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:2

    Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dinoprostone; Gastric

2010
Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration.
    European journal of pharmacology, 2010, Jul-10, Volume: 637, Issue:1-3

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Benzoates; Blood Glu

2010
Mediation of vascular relaxation in epineurial arterioles of the sciatic nerve: effect of diabetes in type 1 and type 2 diabetic rat models.
    Endothelium : journal of endothelial cell research, 2003, Volume: 10, Issue:2

    Topics: Acetylcholine; Animals; Arterioles; Biological Factors; Diabetes Mellitus, Experimental; Diabetes Me

2003
Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery.
    British journal of pharmacology, 2003, Volume: 140, Issue:7

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Cardiovascular Agents; Catalase; Charybdotoxin; Dia

2003
Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats.
    Canadian journal of physiology and pharmacology, 2004, Volume: 82, Issue:3

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Biological Factors; Chlorides; Diabetes Mellitus, Experimen

2004
Lack of potentiation of bradykinin by angiotensin-(1-7) in a type 2 diabetes model: role of insulin.
    Peptides, 2007, Volume: 28, Issue:5

    Topics: Angiotensin I; Animals; Animals, Newborn; Blood Glucose; Bradykinin; Diabetes Mellitus, Type 2; Drug

2007
The role of endogenous opioids in the chlorpropamide alcohol flush.
    Clinical endocrinology, 1984, Volume: 21, Issue:5

    Topics: Administration, Oral; Adult; Aged; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Interactions; Enk

1984
Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus.
    FEBS letters, 1995, Jul-17, Volume: 368, Issue:2

    Topics: Adult; Aspirin; Chromatography, Gas; Diabetes Mellitus, Type 2; Dinoprost; Esterification; Humans; I

1995
The influence of diabetes on the vasomotor responses of saphenous vein and the development of infra-inguinal vein graft stenosis.
    Diabetes, 1997, Volume: 46, Issue:1

    Topics: Aged; Aged, 80 and over; Amputation, Surgical; Blood Vessel Prosthesis; Bradykinin; Calcimycin; Coll

1997
Non-steroidal anti-inflammatory drugs and metformin: a cause for concern?
    Lancet (London, England), 1998, Jul-18, Volume: 352, Issue:9123

    Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Diabetes

1998
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus.
    General pharmacology, 2000, Volume: 34, Issue:3

    Topics: Acetylcholine; Animals; Aorta; Biological Factors; Blood Glucose; Body Weight; Cardiovascular Agents

2000
[Restoration of insulin sensitivity after correction of hypokalemia due to chronic tubulopathy in a diabetic patient].
    Diabete & metabolisme, 1988, Volume: 14, Issue:6

    Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glucose Clamp Technique; Humans; H

1988
Acetyl-salicylic acid impairs insulin-mediated glucose utilization and reduces insulin clearance in healthy and non-insulin-dependent diabetic man.
    Diabetologia, 1985, Volume: 28, Issue:9

    Topics: Adult; Aspirin; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia;

1985