indomethacin has been researched along with Diabetes Mellitus, Type 1 in 33 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The study indicates that the development of new or the worsening of old diabetic iris and retinal changes, as well as cystoid macular edema, were much less if the intraocular lens was implanted in the capsular bag, at least nine months elapsed between cataract surgery and capsule interruption, and topical indomethacin and topical steroid treatment was given preoperatively and postoperatively." | 3.67 | Posterior capsulotomy in sulcus-fixated versus bag-fixated intraocular lenses in diabetic patients. ( Alpar, JJ, 1985) |
| "Previously, we have demonstrated that patients with normoalbuminuric Type 1 diabetes are characterized by impaired nitric oxide bioavailability compensated for by increased vasodilatory prostanoid-mediated vasodilation." | 2.72 | Angiotensin II does not affect endothelial tone in Type 1 diabetes-results of a double-blind placebo controlled trial. ( Allard, SE; Browne, DL; Cummings, MH; Meeking, DR; Munday, JL; Shaw, KM, 2006) |
| "Patients with type 1 diabetes mellitus (n = 12) and normal control subjects (n = 12) were studied in a series of six experiments, each on different occasions." | 2.70 | Effects of amino acids and glucagon on renal hemodynamics in type 1 diabetes. ( Cooney, SK; Puhlman, ME; Short, RA; Tuttle, KR, 2002) |
| "Twenty-five patients with IDDM, aged 24 +/- 6 years, entered the trial within 8 weeks of the onset of diabetes." | 2.67 | Prednisone administration in recent onset type I diabetes. ( Pastore, MR; Pontiroli, AE; Pozza, G; Secchi, A; Sergi, A, 1990) |
| "Indomethacin treatment induced a significant reduction in urinary prostaglandin E2 excretion (73%) (2p less than 0." | 2.66 | Elevated urinary prostaglandin excretion and the effect of indomethacin on renal function in incipient diabetic nephropathy. ( Hommel, E; Mathiesen, ER; Olsen, UB; Parving, HH, 1988) |
| "Indomethacin treatment induced a significant reduction in urinary prostaglandin E2 excretion (73%, p less than 0." | 2.66 | Effects of indomethacin on kidney function in type 1 (insulin-dependent) diabetic patients with nephropathy. ( Arnold-Larsen, S; Edsberg, B; Hommel, E; Mathiesen, E; Olsen, UB; Parving, HH, 1987) |
| "The indomethacin-induced increase in pressure was reduced in diabetes (2." | 1.33 | Dysfunction of the cyclo-oxygenase pathway in the foetoplacental circulation in Type 1 diabetes mellitus. ( Bisseling, TM; Elving, L; Russel, FG; Smits, P; Steegers, EA; Wouterse, AC, 2005) |
| "Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease believed to be caused by an inflammatory process in the pancreas leading to selective destruction of the beta cells." | 1.31 | COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice. ( Floyd, RA; Jacob, JM; Kotake, Y; Tabatabaie, T; Waldon, AM, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (36.36) | 18.7374 |
| 1990's | 10 (30.30) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roganović, J | 1 |
| Radenković, M | 1 |
| Tanić, N | 2 |
| Petrović, N | 1 |
| Stojić, D | 1 |
| Ang, C | 1 |
| Hillier, C | 1 |
| Johnston, F | 1 |
| Cameron, A | 1 |
| Greer, I | 1 |
| Lumsden, MA | 1 |
| Coppey, LJ | 1 |
| Gellett, JS | 1 |
| Yorek, MA | 1 |
| Bisseling, TM | 1 |
| Wouterse, AC | 1 |
| Steegers, EA | 1 |
| Elving, L | 1 |
| Russel, FG | 1 |
| Smits, P | 1 |
| Browne, DL | 2 |
| Meeking, DR | 2 |
| Allard, SE | 1 |
| Munday, JL | 1 |
| Shaw, KM | 2 |
| Cummings, MH | 2 |
| Suresh, Y | 1 |
| Das, UN | 1 |
| Roca, V | 1 |
| Larocca, L | 1 |
| Calafat, M | 1 |
| Aisemberg, J | 1 |
| Meiss, R | 1 |
| Franchi, AM | 1 |
| Leirós, CP | 1 |
| Malakul, W | 1 |
| Thirawarapan, S | 1 |
| Suvitayavat, W | 1 |
| Woodman, OL | 1 |
| Prud'homme, GJ | 1 |
| Fuks, A | 1 |
| Colle, E | 1 |
| Seemayer, TA | 1 |
| Guttmann, RD | 1 |
| Valerio, G | 1 |
| Gasparini, N | 1 |
| Badolato, R | 1 |
| Di Maio, S | 1 |
| Tenore, A | 1 |
| Rudberg, S | 1 |
| Sätterström, G | 1 |
| Dahlqvist, R | 1 |
| Dahlquist, G | 1 |
| Avogaro, A | 2 |
| Crepaldi, C | 1 |
| Piarulli, F | 1 |
| Milan, D | 1 |
| Valerio, A | 2 |
| Pavan, P | 1 |
| Sacerdoti, D | 3 |
| Calabrò, A | 1 |
| Macdonald, I | 1 |
| Crepaldi, G | 1 |
| Scognamiglio, R | 1 |
| Tiengo, A | 1 |
| Pieper, GM | 1 |
| Moore-Hilton, G | 1 |
| Roza, AM | 1 |
| Wascher, TC | 1 |
| Bachernegg, M | 1 |
| Kickenweiz, A | 1 |
| Stark, G | 1 |
| Stark, U | 1 |
| Toplak, H | 1 |
| Graier, WF | 1 |
| Hicks, RC | 1 |
| Moss, J | 1 |
| Higman, DJ | 1 |
| Greenhalgh, RM | 1 |
| Powell, JT | 1 |
| Man'kovskiĭ, BN | 1 |
| Tadzhieva, DCh | 1 |
| Tabatabaie, T | 1 |
| Waldon, AM | 1 |
| Jacob, JM | 1 |
| Floyd, RA | 1 |
| Kotake, Y | 1 |
| Allard, S | 1 |
| Munday, J | 1 |
| Chowienczyck, PJ | 1 |
| Tuttle, KR | 1 |
| Puhlman, ME | 1 |
| Cooney, SK | 1 |
| Short, RA | 1 |
| Waitzman, MB | 1 |
| Fioretto, P | 2 |
| Sambataro, M | 1 |
| Cipollina, MG | 1 |
| Duner, E | 1 |
| Giorato, C | 1 |
| Morocutti, A | 1 |
| Mollo, F | 1 |
| Ben, GP | 1 |
| Carraro, A | 1 |
| Secchi, A | 2 |
| Pastore, MR | 1 |
| Sergi, A | 1 |
| Pontiroli, AE | 2 |
| Pozza, G | 2 |
| Trevisan, R | 1 |
| Borsato, M | 1 |
| Doria, A | 1 |
| Semplicini, A | 1 |
| Jones, S | 1 |
| Bognetti, E | 1 |
| Bruserud, O | 2 |
| Thorsby, E | 2 |
| Jenkins, DA | 1 |
| Craig, K | 1 |
| Collier, A | 1 |
| Watson, ML | 1 |
| Clarke, BF | 1 |
| Kawase, Y | 1 |
| Yokono, K | 1 |
| Nagata, M | 1 |
| Hatamori, N | 1 |
| Akiyama, H | 1 |
| Sakamoto, T | 1 |
| Yonezawa, K | 1 |
| Yaso, S | 1 |
| Shii, K | 1 |
| Baba, S | 1 |
| Christiansen, JS | 1 |
| Feldt-Rasmussen, B | 1 |
| Parving, HH | 3 |
| Mathiesen, ER | 1 |
| Hommel, E | 2 |
| Olsen, UB | 2 |
| van den Berg, BW | 1 |
| Kruseman, AC | 1 |
| van Geel, JL | 1 |
| Cornelissen, P | 1 |
| Mulder, AW | 1 |
| Mathiesen, E | 1 |
| Arnold-Larsen, S | 1 |
| Edsberg, B | 1 |
| Falqui, L | 1 |
| Pastore, RM | 1 |
| Scorza, R | 1 |
| Meroni, PL | 1 |
| Alpar, JJ | 1 |
1 review available for indomethacin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Proposed metabolic dysfunctions in diabetic microthromboses and microangiopathy.
Topics: Alprostadil; Aspirin; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Cyclic GMP; Diabetes Mellit | 1979 |
8 trials available for indomethacin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Angiotensin II does not affect endothelial tone in Type 1 diabetes-results of a double-blind placebo controlled trial.
Topics: Acetylcholine; Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; C | 2006 |
Indomethacin but not metoprolol reduces exercise-induced albumin excretion rate in type 1 diabetic patients with microalbuminuria.
Topics: Adult; Albuminuria; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies | 1993 |
The hemodynamic abnormalities in short-term insulin deficiency: the role of prostaglandin inhibition.
Topics: 3-Hydroxybutyric Acid; 6-Ketoprostaglandin F1 alpha; Acetoacetates; Adult; Blood Glucose; Diabetes M | 1996 |
Effects of amino acids and glucagon on renal hemodynamics in type 1 diabetes.
Topics: Adult; Amino Acids; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Blood Pressure; Diabetes | 2002 |
Prednisone administration in recent onset type I diabetes.
Topics: Adolescent; Adult; Analysis of Variance; B-Lymphocytes; Blood Glucose; C-Peptide; Diabetes Mellitus, | 1990 |
Short-term inhibition of prostaglandin synthesis has no effect on the elevated glomerular filtration rate of early insulin-dependent diabetes.
Topics: Adult; Diabetes Mellitus, Type 1; Double-Blind Method; Glomerular Filtration Rate; Humans; Indometha | 1985 |
Elevated urinary prostaglandin excretion and the effect of indomethacin on renal function in incipient diabetic nephropathy.
Topics: Adult; Albuminuria; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dinoprostone; Female; Glomeru | 1988 |
Effects of indomethacin on kidney function in type 1 (insulin-dependent) diabetic patients with nephropathy.
Topics: Adult; Albuminuria; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dinoprostone; Double-Blind Me | 1987 |
24 other studies available for indomethacin and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated parotid artery of the alloxan-induced diabetic rabbit.
Topics: Acetylcholine; Alloxan; Animals; Arteries; Bradykinin; Cyclooxygenase Inhibitors; Diabetes Mellitus, | 2011 |
Endothelial function is preserved in pregnant women with well-controlled type 1 diabetes.
Topics: Adult; Analysis of Variance; Arteries; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 1; Endothe | 2002 |
Mediation of vascular relaxation in epineurial arterioles of the sciatic nerve: effect of diabetes in type 1 and type 2 diabetic rat models.
Topics: Acetylcholine; Animals; Arterioles; Biological Factors; Diabetes Mellitus, Experimental; Diabetes Me | 2003 |
Dysfunction of the cyclo-oxygenase pathway in the foetoplacental circulation in Type 1 diabetes mellitus.
Topics: Adult; Blood Pressure; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 1; Female; Humans; In Vitr | 2005 |
Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus.
Topics: Alloxan; Animals; Arachidonic Acid; Blood Glucose; Body Weight; Catalase; Ceruloplasmin; Diabetes Me | 2006 |
Reduced nitric oxide synthase and cyclo-oxygenase activity in the uterus of non-obese diabetic mice.
Topics: Animals; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 1; Dinoprostone; Enzyme Activation; Fema | 2006 |
Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Biological Factors; Blood Glucose; Body Weight; Cha | 2008 |
Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages.
Topics: Animals; Catalase; Cell Separation; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Human | 1984 |
Impairment of T-cell growth-promoting lymphokines in human insulin-dependent diabetes mellitus.
Topics: Adolescent; Biological Assay; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Hexosamine | 1994 |
Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Diabetes Mellitus, Type 1; Endothelium, Vascular; | 1996 |
Involvement of the L-arginine-nitric oxide pathway in hyperglycaemia-induced coronary artery dysfunction of isolated guinea pig hearts.
Topics: Animals; Arginine; Blood Circulation; Coronary Vessels; Diabetes Mellitus, Type 1; Female; Glucose; | 1996 |
The influence of diabetes on the vasomotor responses of saphenous vein and the development of infra-inguinal vein graft stenosis.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Blood Vessel Prosthesis; Bradykinin; Calcimycin; Coll | 1997 |
[A drug test with indomethacin in the diagnosis of subclinical forms of diabetic nephropathy].
Topics: Adolescent; Adult; Albuminuria; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diabetes M | 1999 |
COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice.
Topics: Animals; Blood Glucose; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Di | 2000 |
Effects of cyclo-oxygenase inhibition on vasodilatory response to acetylcholine in patients with type 1 diabetes and nondiabetic subjects.
Topics: Acetylcholine; Adult; Blood Flow Velocity; Body Mass Index; Cyclooxygenase Inhibitors; Diabetes Mell | 2000 |
Impaired response to angiotensin II in type 1 (insulin-dependent) diabetes mellitus. Role of prostaglandins and sodium-lithium countertransport activity.
Topics: Adult; Albuminuria; Angiotensin II; Antiporters; Blood Pressure; Carrier Proteins; Diabetes Mellitus | 1991 |
Impaired renal response to a meat meal in insulin-dependent diabetes: role of glucagon and prostaglandins.
Topics: Adult; Diabetes Mellitus, Type 1; Dietary Proteins; Eating; Female; Glucagon; Hemodynamics; Hormones | 1990 |
HLA control of the proliferative T lymphocyte response to antigenic determinants on mumps virus. Studies of healthy individuals and patients with type 1 diabetes.
Topics: Antibodies, Monoclonal; Antigens, Viral; Capsid; Cross Reactions; Diabetes Mellitus, Type 1; Epitope | 1985 |
Evidence against a role for prostaglandins in sustaining renal hyperfiltration in type 1 diabetes mellitus.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Albuminuria; Blood Glucose; Blood Pressure; Diabetes Mellitus, | 1989 |
[Cellular immune dysfunction in the NOD mouse: suppression of concanavalin A-induced responses in spleen cells by activated macrophages].
Topics: Animals; Cell Division; Concanavalin A; Diabetes Mellitus, Type 1; Female; Immunity, Cellular; Immun | 1989 |
T lymphocyte responses to Coxsackie B4 and mumps virus. I. Influence of HLA-DR restriction elements.
Topics: Aminophylline; Antigens, Viral; Diabetes Mellitus, Type 1; Enterovirus; Herpesvirus 3, Human; Histoc | 1985 |
Effect of short-term inhibition of prostaglandin synthesis on glomerular filtration rate and microalbuminuria in patients with incipient diabetic nephropathy.
Topics: Adult; Aged; Albuminuria; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Glomerular Filt | 1988 |
Efficacy of prednisone to induce remission in recent onset type I (insulin dependent) diabetic patients.
Topics: Adult; Diabetes Mellitus, Type 1; Follow-Up Studies; Humans; Indomethacin; Prednisone | 1987 |
Posterior capsulotomy in sulcus-fixated versus bag-fixated intraocular lenses in diabetic patients.
Topics: Aged; Cataract Extraction; Ciliary Body; Diabetes Mellitus, Type 1; Humans; Indomethacin; Laser Ther | 1985 |