indomethacin has been researched along with Dermatitis, Contact in 39 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the role played by prostaglandins (PGs) in contact urticaria, concentrations of 13,14-dihydro-15-keto-PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane B2, the stable metabolites of PGF2 alpha, prostacycline and thromboxane A2 were measured by radio-immunoassay of the fluid taken from suction blisters in 11 patients." | 7.66 | Prostaglandins in contact urticaria induced by benzoic acid. ( Hannuksela, M; Lahti, A; Oikarinen, A; Viinikka, L; Ylikorkala, O, 1983) |
| "The topical effects of N0164 (a phenyl phosphonate derivative which is a partially selective antagonist of prostagladin E2), indomethacin and triamcinolone acetonide have been shown to reduce the erythema and ear weight gain from inflammation induced by experimental contact allergic eczema." | 7.65 | Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis. ( Lowe, NJ; Stoughton, RB; Virgadamo, F, 1977) |
| " Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited DMBA-induced inflammation and local immunosuppression." | 3.71 | Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2. ( Horio, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Tanaka, K; Urade, Y, 2001) |
| "The influence of irritant contact dermatitis on percutaneous penetration was investigated for four 14C-labeled compounds with diverse physicochemical properties: hydrocortisone (HC), indomethacin (IM), ibuprofen (IB), and acitretin (AC)." | 3.68 | Effect of sodium lauryl sulfate-induced skin irritation on in vitro percutaneous absorption of four drugs. ( Maibach, HI; Surber, C; Wilhelm, KP, 1991) |
| "The influence of sodium lauryl sulfate-induced irritant contact dermatitis on in vivo percutaneous penetration was investigated for four 14C-labeled compounds with diverse physicochemical properties: hydrocortisone (HC), indomethacin (IM), ibuprofen (IB), and acitretin (AC)." | 3.68 | Effect of sodium lauryl sulfate-induced skin irritation on in vivo percutaneous penetration of four drugs. ( Maibach, HI; Surber, C; Wilhelm, KP, 1991) |
| "In the present study we examined the effects of chlorpheniramine and ranitidine, indomethacin, BW755C (an inhibitor of cyclo-oxygenase and lipo-oxygenase enzymes of arachidonic acid metabolism), dexamethasone, and capsaicin on nonimmunologic contact urticaria (NICU) induced in the guinea pig ear by benzoic, acid cinnamic acid, cinnamic aldehyde, methyl nicotinate, diethyl fumarate, or dimethyl sulfoxide." | 3.67 | Pharmacological studies on nonimmunologic contact urticaria in guinea pigs. ( Lahti, A; Maibach, HI; McDonald, DM; Tammi, R, 1986) |
| "The effect of topical clobetasol propionate and a 1% topical indomethacin gel which could inhibit UV erythema was measured on anthralin inflammation by change in skin-fold thickness and erythema." | 3.67 | Mechanism of anthralin inflammation. I. Dissociation of response to clobetasol and indomethacin. ( Lawrence, CM; Shuster, S, 1985) |
| "To study the role played by prostaglandins (PGs) in contact urticaria, concentrations of 13,14-dihydro-15-keto-PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane B2, the stable metabolites of PGF2 alpha, prostacycline and thromboxane A2 were measured by radio-immunoassay of the fluid taken from suction blisters in 11 patients." | 3.66 | Prostaglandins in contact urticaria induced by benzoic acid. ( Hannuksela, M; Lahti, A; Oikarinen, A; Viinikka, L; Ylikorkala, O, 1983) |
| "The topical effects of N0164 (a phenyl phosphonate derivative which is a partially selective antagonist of prostagladin E2), indomethacin and triamcinolone acetonide have been shown to reduce the erythema and ear weight gain from inflammation induced by experimental contact allergic eczema." | 3.65 | Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis. ( Lowe, NJ; Stoughton, RB; Virgadamo, F, 1977) |
| "A reduced contact hypersensitivity response was found in mice injected with CD11c(+) cells from the UV-irradiated animals compared with those injected with cells from the nonirradiated animals." | 1.36 | Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+ cells via an indomethacin-inhibitable pathway. ( Bisley, JL; Gorman, S; Hart, PH; Ng, RL; Norval, M, 2010) |
| "Treatment with indomethacin, an inhibitor of prostaglandin (PG) synthesis, inhibited UV-induced inflammation and abrogated immunosuppression." | 1.31 | Photobiologic and photoimmunologic characteristics of XPA gene-deficient mice. ( Horiki, S; Horio, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Okamoto, H; Tanaka, K, 2001) |
| "Histamine suppressed contact hypersensitivity responses and the effects of cis-UCA and histamine were not cumulative, suggesting that cis-UCA and histamine signal largely through the same pathway." | 1.30 | Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses. ( el-Ghorr, AA; Finlay-Jones, JJ; Hart, PH; Jaksic, A; Norval, M; Swift, G, 1997) |
| "Treatment with indomethacin could only abrogate the effects of nanogram doses of rIL-1 beta." | 1.28 | In-vivo administration of interleukin 1 both enhances and suppresses contact sensitivity in the mouse. ( Bäck, O; Linna, J, 1992) |
| "Anthralin and UVB were then applied to the gel-treated skin and the anthralin- and UVB-induced erythema and oedema were measured at 2, 6, 24 and 48 h using Harpenden callipers and a reflectance erythrometer." | 1.28 | The effect of indomethacin on anthralin inflammation. ( Lawrence, C; Ramsay, B; Rice, N, 1992) |
| "Indomethacin was found to delay the onset and reduce the size of tumours in BP- but not DMBA-treated mice." | 1.28 | A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice. ( Andrews, J; Halliday, GM; Muller, HK, 1991) |
| " AD-1590 and indomethacin at an oral dosage as high as 32 mg/kg did not show any significant inhibitory activity on rat passive cutaneous anaphylaxis, a type-I allergy, although prednisolone and cyproheptadine produced strong inhibition." | 1.27 | [Inhibitory effect of AD-1590, a non-steroidal anti-inflammatory drug, on allergic inflammation in mice and rats]. ( Ishii, K; Kadokawa, T; Motoyoshi, S; Nakamura, H, 1988) |
| "Indomethacin treatment of low-dose UVR-exposed animals (to inhibit prostaglandin synthesis in vivo) caused a retention in the capacity to respond normally to CH induction to haptens applied to the nonirradiated, but not to irradiated, dorsal skin surfaces." | 1.27 | Involvement of prostaglandins in the immune alterations caused by the exposure of mice to ultraviolet radiation. ( Burnham, DK; Chung, HT; Daynes, RA; Roberts, LK; Robertson, B, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (43.59) | 18.7374 |
| 1990's | 14 (35.90) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 4 (10.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Drews, A | 1 |
| Bovens, S | 1 |
| Roebrock, K | 1 |
| Sunderkötter, C | 1 |
| Reinhardt, D | 1 |
| Schäfers, M | 1 |
| van der Velde, A | 1 |
| Schulze Elfringhoff, A | 1 |
| Fabian, J | 1 |
| Lehr, M | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Dos Santos, CBR | 1 |
| da Silva Ramos, R | 1 |
| Ortiz, BLS | 1 |
| da Silva, GM | 1 |
| Giuliatti, S | 1 |
| Balderas-Lopez, JL | 1 |
| Navarrete, A | 1 |
| Carvalho, JCT | 1 |
| Ng, RL | 1 |
| Bisley, JL | 1 |
| Gorman, S | 1 |
| Norval, M | 2 |
| Hart, PH | 3 |
| Townley, SL | 1 |
| Grimbaldeston, MA | 1 |
| Khalil, Z | 1 |
| Finlay-Jones, JJ | 2 |
| Liu, ZH | 1 |
| Du, XH | 1 |
| Lahti, A | 2 |
| Oikarinen, A | 1 |
| Viinikka, L | 1 |
| Ylikorkala, O | 1 |
| Hannuksela, M | 1 |
| Kato, K | 1 |
| Askenase, PW | 1 |
| Parker, D | 1 |
| Turk, JL | 1 |
| Drossler, K | 1 |
| Bourin, MC | 1 |
| Delescluse, C | 1 |
| Fürstenberger, G | 1 |
| Marks, F | 1 |
| Schweizer, J | 1 |
| Klein-Szanto, AJ | 1 |
| Prunieras, M | 1 |
| Rao, TS | 1 |
| Yu, SS | 1 |
| Djuric, SW | 1 |
| Isakson, PC | 1 |
| Gao, JX | 1 |
| Issekutz, AC | 1 |
| Herbert, MK | 1 |
| Tafler, R | 1 |
| Schmidt, RF | 1 |
| Weis, KH | 1 |
| Puigneró, V | 1 |
| Queralt, J | 1 |
| Jaksic, A | 1 |
| Swift, G | 1 |
| el-Ghorr, AA | 1 |
| Tsuji, F | 1 |
| Miyake, Y | 1 |
| Enomoto, H | 1 |
| Horiuchi, M | 1 |
| Mita, S | 1 |
| Miyauchi-Hashimoto, H | 2 |
| Kuwamoto, K | 2 |
| Urade, Y | 1 |
| Tanaka, K | 2 |
| Horio, T | 2 |
| Horiki, S | 1 |
| Okamoto, H | 1 |
| Lowe, NJ | 1 |
| Virgadamo, F | 1 |
| Stoughton, RB | 1 |
| Weirich, EG | 1 |
| Longauer, JK | 1 |
| Kirkwood, AH | 1 |
| Bäck, O | 1 |
| Linna, J | 1 |
| Ramsay, B | 1 |
| Rice, N | 1 |
| Lawrence, C | 1 |
| Duteil, L | 2 |
| Queille, C | 2 |
| Poncet, M | 2 |
| Czernielewski, J | 2 |
| Wilhelm, KP | 2 |
| Surber, C | 2 |
| Maibach, HI | 3 |
| Andrews, J | 1 |
| Halliday, GM | 1 |
| Muller, HK | 1 |
| Lavaud, P | 1 |
| Rodrigue, F | 1 |
| Carré, C | 1 |
| Touvay, C | 1 |
| Mencia-Huerta, JM | 1 |
| Braquet, P | 1 |
| Ortonne, JP | 1 |
| Puhvel, SM | 1 |
| Sakamoto, M | 1 |
| Reisner, RM | 1 |
| Hambleton, P | 1 |
| Miller, P | 1 |
| Rheins, LA | 1 |
| Barnes, L | 1 |
| Amornsiripanitch, S | 1 |
| Collins, CE | 1 |
| Nordlund, JJ | 1 |
| Beller, U | 1 |
| Kaufmann, R | 1 |
| Jun, BD | 1 |
| Roberts, LK | 2 |
| Cho, BH | 1 |
| Robertson, B | 2 |
| Daynes, RA | 2 |
| Chang, J | 1 |
| Carlson, RP | 1 |
| O'Neill-Davis, L | 1 |
| Lamb, B | 1 |
| Sharma, RN | 1 |
| Lewis, AJ | 1 |
| McDonald, DM | 1 |
| Tammi, R | 1 |
| Nakamura, H | 1 |
| Motoyoshi, S | 1 |
| Ishii, K | 1 |
| Kadokawa, T | 1 |
| Chung, HT | 1 |
| Burnham, DK | 1 |
| Lawrence, CM | 1 |
| Shuster, S | 1 |
| Gieldanowski, J | 1 |
| Pelczarska, A | 1 |
2 trials available for indomethacin and Dermatitis, Contact
| Article | Year |
|---|---|
Cyclooxygenase inhibitors acetylsalicylic acid and indomethacin do not affect capsaicin-induced neurogenic inflammation in human skin.
Topics: Adult; Aspirin; Blood Flow Velocity; Capsaicin; Cyclooxygenase Inhibitors; Dermatitis, Contact; Doub | 1993 |
Processing and statistical analysis of laser Doppler data applied to the assessment of systemic anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dermatitis, Contact; Female; Humans; Indome | 1991 |
37 other studies available for indomethacin and Dermatitis, Contact
| Article | Year |
|---|---|
1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Biological Availabi | 2010 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Oil from the fruits of Pterodon emarginatus Vog.: A traditional anti-inflammatory. Study combining in vivo and in silico.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Croton Oil; Cyclooxygenase | 2018 |
Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+ cells via an indomethacin-inhibitable pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Bone Marrow Cells; CD11c Antige | 2010 |
Mast cells, neuropeptides, histamine, and prostaglandins in UV-induced systemic immunosuppression.
Topics: Animals; Cell Degranulation; Dermatitis, Contact; Female; Histamine; Immune Tolerance; Indomethacin; | 2002 |
Quality of life in patients with facial steroid dermatitis before and after treatment.
Topics: Administration, Topical; Adolescent; Adrenal Cortex Hormones; Adult; Cetirizine; Dermatitis, Contact | 2008 |
Prostaglandins in contact urticaria induced by benzoic acid.
Topics: Adolescent; Adult; Benzoates; Benzoic Acid; Dermatitis, Contact; Dinoprost; Epoprostenol; Female; Hu | 1983 |
Reconstitution of an inactive antigen-specific T cell suppressor factor by incubation of the factor with prostaglandins.
Topics: Animals; Dermatitis, Contact; Dinoprostone; Epitopes; Immunosuppressive Agents; Indomethacin; Lympho | 1984 |
Comparison of DNFB and K2Cr2O7 'flare-up' reactions in the guinea pig.
Topics: Animals; Basophils; Chromates; Dermatitis, Contact; Dinitrofluorobenzene; Eosinophils; Female; Guine | 1984 |
Effect of phorbol esters on guniea pig skin in vivo.
Topics: Animals; Cell Division; Dermatitis, Contact; DNA; Epidermis; Female; Guinea Pigs; Indomethacin; Orni | 1982 |
Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Benzamides; Benzopyra | 1994 |
The effect of ebselen on T-lymphocyte migration to arthritic joints and dermal inflammatory reactions in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Azoles; Chemotaxis, Leuko | 1994 |
Effect of topically applied cyclosporin A on arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation in mouse ear.
Topics: Acetylglucosaminidase; Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory | 1997 |
Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses.
Topics: Animals; Dermatitis, Contact; Dose-Response Relationship, Immunologic; Female; Histamine; Histamine | 1997 |
Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis.
Topics: Aniline Compounds; Animals; Carrageenan; Cysteine; Dermatitis, Contact; Edema; Enzyme Inhibitors; Ep | 1998 |
Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adjuvants, Immunologic; Administration, Cutaneous; Animals; Anti-I | 2001 |
Photobiologic and photoimmunologic characteristics of XPA gene-deficient mice.
Topics: Animals; Apyrase; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dermatit | 2001 |
Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Dermatitis, Contact; Erythema; Indometha | 1977 |
New experimental model for the primary evaluation of topical contra-inflammatory agents.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperature; Clobetasol; C | 1977 |
In-vivo administration of interleukin 1 both enhances and suppresses contact sensitivity in the mouse.
Topics: Animals; Dermatitis, Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, Externa | 1992 |
The effect of indomethacin on anthralin inflammation.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anthralin; Dermatitis, Contact; Edema; Erythema; F | 1992 |
Effect of sodium lauryl sulfate-induced skin irritation on in vitro percutaneous absorption of four drugs.
Topics: Acitretin; Administration, Cutaneous; Administration, Topical; Animals; Anti-Inflammatory Agents; Bo | 1991 |
Effect of sodium lauryl sulfate-induced skin irritation on in vivo percutaneous penetration of four drugs.
Topics: Acitretin; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Co | 1991 |
A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Presenti | 1991 |
Pharmacologic modulation of picryl chloride-induced contact dermatitis in the mouse.
Topics: Animals; Betamethasone; Dermatitis, Contact; Dose-Response Relationship, Drug; Indomethacin; Lactone | 1991 |
Objective assessment of topical corticosteroids and non-steroidal anti-inflammatory drugs in methyl-nicotinate-induced skin inflammation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Bufexamac; Clobetasol; Dermatitis, Co | 1990 |
Effect of TCDD on the density of Langerhans cells in murine skin.
Topics: Adenosine Triphosphatases; Animals; Cell Count; Dermatitis, Contact; Dioxins; Drug Synergism; Female | 1989 |
Studies on carrageenin air pouch inflammation in the rat.
Topics: Animals; Carrageenan; Dermatitis, Contact; Disease Models, Animal; Exudates and Transudates; Indomet | 1989 |
Suppression of the cutaneous immune response following topical application of the prostaglandin PGE2.
Topics: Administration, Topical; Animals; Arachidonic Acid; Arachidonic Acids; Dermatitis, Contact; Dinitrof | 1987 |
Contact dermatitis to indomethacin.
Topics: Administration, Cutaneous; Adult; Dermatitis, Contact; Drug Eruptions; Humans; Indomethacin; Male; P | 1987 |
Parallel recovery of epidermal antigen-presenting cell activity and contact hypersensitivity responses in mice exposed to ultraviolet irradiation: the role of a prostaglandin-dependent mechanism.
Topics: Adenosine Triphosphatases; Animals; Antigen-Presenting Cells; Dermatitis, Contact; Dose-Response Rel | 1988 |
Correlation between mouse skin inflammation induced by arachidonic acid and eicosanoid synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Capillary Permeability; Dermatitis, Contact; Dinoprost | 1986 |
Pharmacological studies on nonimmunologic contact urticaria in guinea pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Cap | 1986 |
[Inhibitory effect of AD-1590, a non-steroidal anti-inflammatory drug, on allergic inflammation in mice and rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Dermatitis, Co | 1988 |
Involvement of prostaglandins in the immune alterations caused by the exposure of mice to ultraviolet radiation.
Topics: Animals; Dermatitis, Contact; Female; Histocompatibility Antigens Class II; Immunization, Passive; I | 1986 |
Mechanism of anthralin inflammation. I. Dissociation of response to clobetasol and indomethacin.
Topics: Adult; Aged; Anthracenes; Anthralin; Betamethasone; Clobetasol; Dermatitis, Contact; Edema; Erythema | 1985 |
Mediators and nonsteroid antiinflammatory drugs in immunologically specific and nonspecific inflammatory processes.
Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis; Bradykinin; Chlor | 1971 |