Page last updated: 2024-10-29

indomethacin and Dermatitis, Contact

indomethacin has been researched along with Dermatitis, Contact in 39 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.

Research Excerpts

ExcerptRelevanceReference
"To study the role played by prostaglandins (PGs) in contact urticaria, concentrations of 13,14-dihydro-15-keto-PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane B2, the stable metabolites of PGF2 alpha, prostacycline and thromboxane A2 were measured by radio-immunoassay of the fluid taken from suction blisters in 11 patients."7.66Prostaglandins in contact urticaria induced by benzoic acid. ( Hannuksela, M; Lahti, A; Oikarinen, A; Viinikka, L; Ylikorkala, O, 1983)
"The topical effects of N0164 (a phenyl phosphonate derivative which is a partially selective antagonist of prostagladin E2), indomethacin and triamcinolone acetonide have been shown to reduce the erythema and ear weight gain from inflammation induced by experimental contact allergic eczema."7.65Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis. ( Lowe, NJ; Stoughton, RB; Virgadamo, F, 1977)
" Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited DMBA-induced inflammation and local immunosuppression."3.71Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2. ( Horio, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Tanaka, K; Urade, Y, 2001)
"The influence of irritant contact dermatitis on percutaneous penetration was investigated for four 14C-labeled compounds with diverse physicochemical properties: hydrocortisone (HC), indomethacin (IM), ibuprofen (IB), and acitretin (AC)."3.68Effect of sodium lauryl sulfate-induced skin irritation on in vitro percutaneous absorption of four drugs. ( Maibach, HI; Surber, C; Wilhelm, KP, 1991)
"The influence of sodium lauryl sulfate-induced irritant contact dermatitis on in vivo percutaneous penetration was investigated for four 14C-labeled compounds with diverse physicochemical properties: hydrocortisone (HC), indomethacin (IM), ibuprofen (IB), and acitretin (AC)."3.68Effect of sodium lauryl sulfate-induced skin irritation on in vivo percutaneous penetration of four drugs. ( Maibach, HI; Surber, C; Wilhelm, KP, 1991)
"In the present study we examined the effects of chlorpheniramine and ranitidine, indomethacin, BW755C (an inhibitor of cyclo-oxygenase and lipo-oxygenase enzymes of arachidonic acid metabolism), dexamethasone, and capsaicin on nonimmunologic contact urticaria (NICU) induced in the guinea pig ear by benzoic, acid cinnamic acid, cinnamic aldehyde, methyl nicotinate, diethyl fumarate, or dimethyl sulfoxide."3.67Pharmacological studies on nonimmunologic contact urticaria in guinea pigs. ( Lahti, A; Maibach, HI; McDonald, DM; Tammi, R, 1986)
"The effect of topical clobetasol propionate and a 1% topical indomethacin gel which could inhibit UV erythema was measured on anthralin inflammation by change in skin-fold thickness and erythema."3.67Mechanism of anthralin inflammation. I. Dissociation of response to clobetasol and indomethacin. ( Lawrence, CM; Shuster, S, 1985)
"To study the role played by prostaglandins (PGs) in contact urticaria, concentrations of 13,14-dihydro-15-keto-PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane B2, the stable metabolites of PGF2 alpha, prostacycline and thromboxane A2 were measured by radio-immunoassay of the fluid taken from suction blisters in 11 patients."3.66Prostaglandins in contact urticaria induced by benzoic acid. ( Hannuksela, M; Lahti, A; Oikarinen, A; Viinikka, L; Ylikorkala, O, 1983)
"The topical effects of N0164 (a phenyl phosphonate derivative which is a partially selective antagonist of prostagladin E2), indomethacin and triamcinolone acetonide have been shown to reduce the erythema and ear weight gain from inflammation induced by experimental contact allergic eczema."3.65Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis. ( Lowe, NJ; Stoughton, RB; Virgadamo, F, 1977)
"A reduced contact hypersensitivity response was found in mice injected with CD11c(+) cells from the UV-irradiated animals compared with those injected with cells from the nonirradiated animals."1.36Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+ cells via an indomethacin-inhibitable pathway. ( Bisley, JL; Gorman, S; Hart, PH; Ng, RL; Norval, M, 2010)
"Treatment with indomethacin, an inhibitor of prostaglandin (PG) synthesis, inhibited UV-induced inflammation and abrogated immunosuppression."1.31Photobiologic and photoimmunologic characteristics of XPA gene-deficient mice. ( Horiki, S; Horio, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Okamoto, H; Tanaka, K, 2001)
"Histamine suppressed contact hypersensitivity responses and the effects of cis-UCA and histamine were not cumulative, suggesting that cis-UCA and histamine signal largely through the same pathway."1.30Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses. ( el-Ghorr, AA; Finlay-Jones, JJ; Hart, PH; Jaksic, A; Norval, M; Swift, G, 1997)
"Treatment with indomethacin could only abrogate the effects of nanogram doses of rIL-1 beta."1.28In-vivo administration of interleukin 1 both enhances and suppresses contact sensitivity in the mouse. ( Bäck, O; Linna, J, 1992)
"Anthralin and UVB were then applied to the gel-treated skin and the anthralin- and UVB-induced erythema and oedema were measured at 2, 6, 24 and 48 h using Harpenden callipers and a reflectance erythrometer."1.28The effect of indomethacin on anthralin inflammation. ( Lawrence, C; Ramsay, B; Rice, N, 1992)
"Indomethacin was found to delay the onset and reduce the size of tumours in BP- but not DMBA-treated mice."1.28A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice. ( Andrews, J; Halliday, GM; Muller, HK, 1991)
" AD-1590 and indomethacin at an oral dosage as high as 32 mg/kg did not show any significant inhibitory activity on rat passive cutaneous anaphylaxis, a type-I allergy, although prednisolone and cyproheptadine produced strong inhibition."1.27[Inhibitory effect of AD-1590, a non-steroidal anti-inflammatory drug, on allergic inflammation in mice and rats]. ( Ishii, K; Kadokawa, T; Motoyoshi, S; Nakamura, H, 1988)
"Indomethacin treatment of low-dose UVR-exposed animals (to inhibit prostaglandin synthesis in vivo) caused a retention in the capacity to respond normally to CH induction to haptens applied to the nonirradiated, but not to irradiated, dorsal skin surfaces."1.27Involvement of prostaglandins in the immune alterations caused by the exposure of mice to ultraviolet radiation. ( Burnham, DK; Chung, HT; Daynes, RA; Roberts, LK; Robertson, B, 1986)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199017 (43.59)18.7374
1990's14 (35.90)18.2507
2000's4 (10.26)29.6817
2010's4 (10.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Drews, A1
Bovens, S1
Roebrock, K1
Sunderkötter, C1
Reinhardt, D1
Schäfers, M1
van der Velde, A1
Schulze Elfringhoff, A1
Fabian, J1
Lehr, M1
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Dos Santos, CBR1
da Silva Ramos, R1
Ortiz, BLS1
da Silva, GM1
Giuliatti, S1
Balderas-Lopez, JL1
Navarrete, A1
Carvalho, JCT1
Ng, RL1
Bisley, JL1
Gorman, S1
Norval, M2
Hart, PH3
Townley, SL1
Grimbaldeston, MA1
Khalil, Z1
Finlay-Jones, JJ2
Liu, ZH1
Du, XH1
Lahti, A2
Oikarinen, A1
Viinikka, L1
Ylikorkala, O1
Hannuksela, M1
Kato, K1
Askenase, PW1
Parker, D1
Turk, JL1
Drossler, K1
Bourin, MC1
Delescluse, C1
Fürstenberger, G1
Marks, F1
Schweizer, J1
Klein-Szanto, AJ1
Prunieras, M1
Rao, TS1
Yu, SS1
Djuric, SW1
Isakson, PC1
Gao, JX1
Issekutz, AC1
Herbert, MK1
Tafler, R1
Schmidt, RF1
Weis, KH1
Puigneró, V1
Queralt, J1
Jaksic, A1
Swift, G1
el-Ghorr, AA1
Tsuji, F1
Miyake, Y1
Enomoto, H1
Horiuchi, M1
Mita, S1
Miyauchi-Hashimoto, H2
Kuwamoto, K2
Urade, Y1
Tanaka, K2
Horio, T2
Horiki, S1
Okamoto, H1
Lowe, NJ1
Virgadamo, F1
Stoughton, RB1
Weirich, EG1
Longauer, JK1
Kirkwood, AH1
Bäck, O1
Linna, J1
Ramsay, B1
Rice, N1
Lawrence, C1
Duteil, L2
Queille, C2
Poncet, M2
Czernielewski, J2
Wilhelm, KP2
Surber, C2
Maibach, HI3
Andrews, J1
Halliday, GM1
Muller, HK1
Lavaud, P1
Rodrigue, F1
Carré, C1
Touvay, C1
Mencia-Huerta, JM1
Braquet, P1
Ortonne, JP1
Puhvel, SM1
Sakamoto, M1
Reisner, RM1
Hambleton, P1
Miller, P1
Rheins, LA1
Barnes, L1
Amornsiripanitch, S1
Collins, CE1
Nordlund, JJ1
Beller, U1
Kaufmann, R1
Jun, BD1
Roberts, LK2
Cho, BH1
Robertson, B2
Daynes, RA2
Chang, J1
Carlson, RP1
O'Neill-Davis, L1
Lamb, B1
Sharma, RN1
Lewis, AJ1
McDonald, DM1
Tammi, R1
Nakamura, H1
Motoyoshi, S1
Ishii, K1
Kadokawa, T1
Chung, HT1
Burnham, DK1
Lawrence, CM1
Shuster, S1
Gieldanowski, J1
Pelczarska, A1

Trials

2 trials available for indomethacin and Dermatitis, Contact

ArticleYear
Cyclooxygenase inhibitors acetylsalicylic acid and indomethacin do not affect capsaicin-induced neurogenic inflammation in human skin.
    Agents and actions, 1993, Volume: 38 Spec No

    Topics: Adult; Aspirin; Blood Flow Velocity; Capsaicin; Cyclooxygenase Inhibitors; Dermatitis, Contact; Doub

1993
Processing and statistical analysis of laser Doppler data applied to the assessment of systemic anti-inflammatory drugs.
    Journal of dermatological science, 1991, Volume: 2, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dermatitis, Contact; Female; Humans; Indome

1991

Other Studies

37 other studies available for indomethacin and Dermatitis, Contact

ArticleYear
1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity.
    Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Biological Availabi

2010
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Oil from the fruits of Pterodon emarginatus Vog.: A traditional anti-inflammatory. Study combining in vivo and in silico.
    Journal of ethnopharmacology, 2018, Aug-10, Volume: 222

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Croton Oil; Cyclooxygenase

2018
Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+ cells via an indomethacin-inhibitable pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Dec-15, Volume: 185, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Bone Marrow Cells; CD11c Antige

2010
Mast cells, neuropeptides, histamine, and prostaglandins in UV-induced systemic immunosuppression.
    Methods (San Diego, Calif.), 2002, Volume: 28, Issue:1

    Topics: Animals; Cell Degranulation; Dermatitis, Contact; Female; Histamine; Immune Tolerance; Indomethacin;

2002
Quality of life in patients with facial steroid dermatitis before and after treatment.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2008, Volume: 22, Issue:6

    Topics: Administration, Topical; Adolescent; Adrenal Cortex Hormones; Adult; Cetirizine; Dermatitis, Contact

2008
Prostaglandins in contact urticaria induced by benzoic acid.
    Acta dermato-venereologica, 1983, Volume: 63, Issue:5

    Topics: Adolescent; Adult; Benzoates; Benzoic Acid; Dermatitis, Contact; Dinoprost; Epoprostenol; Female; Hu

1983
Reconstitution of an inactive antigen-specific T cell suppressor factor by incubation of the factor with prostaglandins.
    Journal of immunology (Baltimore, Md. : 1950), 1984, Volume: 133, Issue:4

    Topics: Animals; Dermatitis, Contact; Dinoprostone; Epitopes; Immunosuppressive Agents; Indomethacin; Lympho

1984
Comparison of DNFB and K2Cr2O7 'flare-up' reactions in the guinea pig.
    International archives of allergy and applied immunology, 1984, Volume: 73, Issue:2

    Topics: Animals; Basophils; Chromates; Dermatitis, Contact; Dinitrofluorobenzene; Eosinophils; Female; Guine

1984
Effect of phorbol esters on guniea pig skin in vivo.
    Carcinogenesis, 1982, Volume: 3, Issue:6

    Topics: Animals; Cell Division; Dermatitis, Contact; DNA; Epidermis; Female; Guinea Pigs; Indomethacin; Orni

1982
Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor.
    Journal of lipid mediators and cell signalling, 1994, Volume: 10, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Benzamides; Benzopyra

1994
The effect of ebselen on T-lymphocyte migration to arthritic joints and dermal inflammatory reactions in the rat.
    International journal of immunopharmacology, 1994, Volume: 16, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Azoles; Chemotaxis, Leuko

1994
Effect of topically applied cyclosporin A on arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation in mouse ear.
    Inflammation, 1997, Volume: 21, Issue:3

    Topics: Acetylglucosaminidase; Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory

1997
Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses.
    Immunology, 1997, Volume: 91, Issue:4

    Topics: Animals; Dermatitis, Contact; Dose-Response Relationship, Immunologic; Female; Histamine; Histamine

1997
Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis.
    European journal of pharmacology, 1998, Apr-03, Volume: 346, Issue:1

    Topics: Aniline Compounds; Animals; Carrageenan; Cysteine; Dermatitis, Contact; Edema; Enzyme Inhibitors; Ep

1998
Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2.
    Journal of immunology (Baltimore, Md. : 1950), 2001, May-01, Volume: 166, Issue:9

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adjuvants, Immunologic; Administration, Cutaneous; Animals; Anti-I

2001
Photobiologic and photoimmunologic characteristics of XPA gene-deficient mice.
    The journal of investigative dermatology. Symposium proceedings, 2001, Volume: 6, Issue:1

    Topics: Animals; Apyrase; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dermatit

2001
Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis.
    The British journal of dermatology, 1977, Volume: 96, Issue:4

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Dermatitis, Contact; Erythema; Indometha

1977
New experimental model for the primary evaluation of topical contra-inflammatory agents.
    Archives for dermatological research = Archiv fur dermatologische Forschung, 1977, Aug-22, Volume: 259, Issue:2

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperature; Clobetasol; C

1977
In-vivo administration of interleukin 1 both enhances and suppresses contact sensitivity in the mouse.
    The British journal of dermatology, 1992, Volume: 126, Issue:2

    Topics: Animals; Dermatitis, Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, Externa

1992
The effect of indomethacin on anthralin inflammation.
    The British journal of dermatology, 1992, Volume: 126, Issue:3

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anthralin; Dermatitis, Contact; Edema; Erythema; F

1992
Effect of sodium lauryl sulfate-induced skin irritation on in vitro percutaneous absorption of four drugs.
    The Journal of investigative dermatology, 1991, Volume: 96, Issue:6

    Topics: Acitretin; Administration, Cutaneous; Administration, Topical; Animals; Anti-Inflammatory Agents; Bo

1991
Effect of sodium lauryl sulfate-induced skin irritation on in vivo percutaneous penetration of four drugs.
    The Journal of investigative dermatology, 1991, Volume: 97, Issue:5

    Topics: Acitretin; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Co

1991
A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice.
    Clinical and experimental immunology, 1991, Volume: 85, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Presenti

1991
Pharmacologic modulation of picryl chloride-induced contact dermatitis in the mouse.
    The Journal of investigative dermatology, 1991, Volume: 97, Issue:1

    Topics: Animals; Betamethasone; Dermatitis, Contact; Dose-Response Relationship, Drug; Indomethacin; Lactone

1991
Objective assessment of topical corticosteroids and non-steroidal anti-inflammatory drugs in methyl-nicotinate-induced skin inflammation.
    Clinical and experimental dermatology, 1990, Volume: 15, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Bufexamac; Clobetasol; Dermatitis, Co

1990
Effect of TCDD on the density of Langerhans cells in murine skin.
    Toxicology and applied pharmacology, 1989, Jun-01, Volume: 99, Issue:1

    Topics: Adenosine Triphosphatases; Animals; Cell Count; Dermatitis, Contact; Dioxins; Drug Synergism; Female

1989
Studies on carrageenin air pouch inflammation in the rat.
    British journal of experimental pathology, 1989, Volume: 70, Issue:4

    Topics: Animals; Carrageenan; Dermatitis, Contact; Disease Models, Animal; Exudates and Transudates; Indomet

1989
Suppression of the cutaneous immune response following topical application of the prostaglandin PGE2.
    Cellular immunology, 1987, Apr-15, Volume: 106, Issue:1

    Topics: Administration, Topical; Animals; Arachidonic Acid; Arachidonic Acids; Dermatitis, Contact; Dinitrof

1987
Contact dermatitis to indomethacin.
    Contact dermatitis, 1987, Volume: 17, Issue:2

    Topics: Administration, Cutaneous; Adult; Dermatitis, Contact; Drug Eruptions; Humans; Indomethacin; Male; P

1987
Parallel recovery of epidermal antigen-presenting cell activity and contact hypersensitivity responses in mice exposed to ultraviolet irradiation: the role of a prostaglandin-dependent mechanism.
    The Journal of investigative dermatology, 1988, Volume: 90, Issue:3

    Topics: Adenosine Triphosphatases; Animals; Antigen-Presenting Cells; Dermatitis, Contact; Dose-Response Rel

1988
Correlation between mouse skin inflammation induced by arachidonic acid and eicosanoid synthesis.
    Inflammation, 1986, Volume: 10, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Capillary Permeability; Dermatitis, Contact; Dinoprost

1986
Pharmacological studies on nonimmunologic contact urticaria in guinea pigs.
    Archives of dermatological research, 1986, Volume: 279, Issue:1

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Cap

1986
[Inhibitory effect of AD-1590, a non-steroidal anti-inflammatory drug, on allergic inflammation in mice and rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1988, Volume: 92, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Dermatitis, Co

1988
Involvement of prostaglandins in the immune alterations caused by the exposure of mice to ultraviolet radiation.
    Journal of immunology (Baltimore, Md. : 1950), 1986, Oct-15, Volume: 137, Issue:8

    Topics: Animals; Dermatitis, Contact; Female; Histocompatibility Antigens Class II; Immunization, Passive; I

1986
Mechanism of anthralin inflammation. I. Dissociation of response to clobetasol and indomethacin.
    The British journal of dermatology, 1985, Volume: 113, Issue:1

    Topics: Adult; Aged; Anthracenes; Anthralin; Betamethasone; Clobetasol; Dermatitis, Contact; Edema; Erythema

1985
Mediators and nonsteroid antiinflammatory drugs in immunologically specific and nonspecific inflammatory processes.
    Archivum immunologiae et therapiae experimentalis, 1971, Volume: 19, Issue:1

    Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis; Bradykinin; Chlor

1971