indomethacin has been researched along with Depression in 13 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effectiveness of a rectal nonsteroidal anti-inflammatory drug (indomethacin) for pain relief during a hysterosalpingography (HSG)." | 9.22 | Rectal indomethacin use in pain relief during hysterosalpingography: A randomized placebo controlled trial. ( Alkış, İ; Çim, N; Karaman, E; Yıldırım, A; Yıldızhan, R, 2016) |
| "Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days." | 5.51 | Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice. ( Hajhashemi, V; Mesripour, A; Shahnooshi, S, 2019) |
| "To evaluate the effectiveness of a rectal nonsteroidal anti-inflammatory drug (indomethacin) for pain relief during a hysterosalpingography (HSG)." | 5.22 | Rectal indomethacin use in pain relief during hysterosalpingography: A randomized placebo controlled trial. ( Alkış, İ; Çim, N; Karaman, E; Yıldırım, A; Yıldızhan, R, 2016) |
| "Imipramine was used as a reference compound, as its action is connected with mGlu5 receptor." | 1.56 | Indomethacin, a nonselective cyclooxygenase inhibitor, does not interact with MTEP in antidepressant-like activity, as opposed to imipramine in CD-1 mice. ( Stachowicz, K, 2020) |
| "Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days." | 1.51 | Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice. ( Hajhashemi, V; Mesripour, A; Shahnooshi, S, 2019) |
| "Pretreatment with indomethacin (10mg/kg; i." | 1.36 | Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice. ( Andrade, CA; de Paiva, VN; Fernandes, MM; Giusti-Paiva, A; Lima, SN; Soncini, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Huang, Z | 1 |
| Yin, L | 1 |
| Guan, L | 1 |
| Li, Z | 1 |
| Tan, C | 1 |
| Mesripour, A | 1 |
| Shahnooshi, S | 1 |
| Hajhashemi, V | 1 |
| Stachowicz, K | 1 |
| Karaman, E | 1 |
| Çim, N | 1 |
| Alkış, İ | 1 |
| Yıldırım, A | 1 |
| Yıldızhan, R | 1 |
| Lambru, G | 1 |
| Castellini, P | 1 |
| Bini, A | 1 |
| Evangelista, A | 1 |
| Manzoni, GC | 1 |
| Torelli, P | 1 |
| de Paiva, VN | 1 |
| Lima, SN | 1 |
| Fernandes, MM | 1 |
| Soncini, R | 1 |
| Andrade, CA | 1 |
| Giusti-Paiva, A | 1 |
| Deak, T | 1 |
| Bellamy, C | 1 |
| D'Agostino, LG | 1 |
| Rosanoff, M | 1 |
| McElderry, NK | 1 |
| Bordner, KA | 1 |
| Mathé, AA | 1 |
| Lloyd, DB | 1 |
| Asberg, M | 1 |
| Bertilsson, L | 1 |
| Cronholm, B | 1 |
| Härfast, A | 1 |
| Sjöqvist, F | 1 |
| Tuck, D | 1 |
| Carson, RW | 1 |
| Cohn, P | 1 |
| Levinson, JE | 1 |
| Plotz, CM | 1 |
| Sanchez, RC | 1 |
| Smyth, CJ | 1 |
| Ward, JR | 1 |
| Weiss, T | 1 |
1 review available for indomethacin and Depression
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
1 trial available for indomethacin and Depression
| Article | Year |
|---|---|
Rectal indomethacin use in pain relief during hysterosalpingography: A randomized placebo controlled trial.
Topics: Administration, Rectal; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Depression; Female; | 2016 |
11 other studies available for indomethacin and Depression
| Article | Year |
|---|---|
Novel piperazine-2,5-dione analogs bearing 1H-indole: Synthesis and biological effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Depression; Drug Discovery; In | 2020 |
Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Depression; Disease M | 2019 |
Indomethacin, a nonselective cyclooxygenase inhibitor, does not interact with MTEP in antidepressant-like activity, as opposed to imipramine in CD-1 mice.
Topics: Animals; Antidepressive Agents; Cyclooxygenase Inhibitors; Depression; Drug Interactions; Hindlimb S | 2020 |
Hemicrania continua evolving from cluster headache responsive to valproic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Depression; Dyspepsia; Female; GABA Agents; Gastritis; Head | 2008 |
Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Depression; Dexamethason | 2010 |
Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharide.
Topics: alpha-MSH; Analysis of Variance; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic | 2005 |
False normal dexamethasone suppression test and indomethacin.
Topics: Depression; Dexamethasone; False Positive Reactions; Humans; Hydrocortisone; Indomethacin; Male; Pro | 1982 |
Depression on withdrawal of indomethacin.
Topics: Aged; Arthritis; Depression; Female; Humans; Indomethacin; Substance Withdrawal Syndrome | 1992 |
[Studies of indolamine metabolites in cerebrospinal fluid in depression].
Topics: Depression; Female; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Indomethacin; Male; Mass S | 1972 |
Unremitting disease in a young mother.
Topics: Adult; Arthritis, Rheumatoid; Depression; Female; Humans; Indomethacin; Osteoporosis; Phenylbutazone | 1972 |
[Central nervous system effects with the use of indomethacin. Special relationship to depression].
Topics: Depression; Humans; Indomethacin | 1972 |