indomethacin has been researched along with Dementias, Transmissible in 2 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prion diseases are characterized by accumulation of protease resistant isoforms of prion protein (termed PrP(SC)), glial activation and neurodegeneration." | 1.31 | Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2. ( Boshuizen, RS; Eikelenboom, P; Hoozemans, JJ; Janssen, I; Langeveld, JP; Veerhuis, R, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, GR | 1 |
| Sharkey, KA | 1 |
| Jirik, FR | 1 |
| Veerhuis, R | 1 |
| Hoozemans, JJ | 1 |
| Janssen, I | 1 |
| Boshuizen, RS | 1 |
| Langeveld, JP | 1 |
| Eikelenboom, P | 1 |
2 other studies available for indomethacin and Dementias, Transmissible
| Article | Year |
|---|---|
Orally administered indomethacin acutely reduces cellular prion protein in the small intestine and modestly increases survival of mice exposed to infectious prions.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Indomethac | 2015 |
Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Cells, Cultured | 2002 |