Page last updated: 2024-10-29

indomethacin and Cystinosis

indomethacin has been researched along with Cystinosis in 4 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Cystinosis: A metabolic disease characterized by the defective transport of CYSTINE across the lysosomal membrane due to mutation of a membrane protein cystinosin. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. In the KIDNEY, nephropathic cystinosis is a common cause of RENAL FANCONI SYNDROME.

Research Excerpts

ExcerptRelevanceReference
"Three children with nephropathic cystinosis were treated with indomethacin 3 mg/kg a day for periods ranging from 9 to 18 months."7.66Effect of indomethacin on clinical progress and renal function in cystinosis. ( Al-Dahhan, J; Chantler, C; Haycock, GB; Mak, RH, 1982)
"Only indomethacin treatment was successful in reversing the biochemical abnormalities and improving the growth pattern."6.65Successful indomethacin treatment of two paediatric patients with severe tubulopathies. A boy with an unusual hypercalciuria and a girl with cystinosis. ( Bétend, B; David, L; François, R; Hermier, M; Vincent, M, 1979)
"Three children with nephropathic cystinosis were treated with indomethacin 3 mg/kg a day for periods ranging from 9 to 18 months."3.66Effect of indomethacin on clinical progress and renal function in cystinosis. ( Al-Dahhan, J; Chantler, C; Haycock, GB; Mak, RH, 1982)
"Only indomethacin treatment was successful in reversing the biochemical abnormalities and improving the growth pattern."2.65Successful indomethacin treatment of two paediatric patients with severe tubulopathies. A boy with an unusual hypercalciuria and a girl with cystinosis. ( Bétend, B; David, L; François, R; Hermier, M; Vincent, M, 1979)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lemire, J1
Kaplan, BS1
Haycock, GB1
Al-Dahhan, J1
Mak, RH1
Chantler, C1
Bétend, B1
David, L1
Vincent, M1
Hermier, M1
François, R1
Pintos-Morell, G1
Jean, G1
Dechaux, M1
Niaudet, P1

Trials

1 trial available for indomethacin and Cystinosis

ArticleYear
Successful indomethacin treatment of two paediatric patients with severe tubulopathies. A boy with an unusual hypercalciuria and a girl with cystinosis.
    Helvetica paediatrica acta, 1979, Volume: 34, Issue:4

    Topics: Aldosterone; Body Water; Calcium; Child, Preschool; Clinical Trials as Topic; Cystinosis; Fanconi Sy

1979

Other Studies

3 other studies available for indomethacin and Cystinosis

ArticleYear
The various renal manifestations of the nephropathic form of cystinosis.
    American journal of nephrology, 1984, Volume: 4, Issue:2

    Topics: Aldosterone; Bartter Syndrome; Child, Preschool; Cystinosis; Desoxycorticosterone; Diabetes Insipidu

1984
Effect of indomethacin on clinical progress and renal function in cystinosis.
    Archives of disease in childhood, 1982, Volume: 57, Issue:12

    Topics: Body Water; Child; Child, Preschool; Cystinosis; Female; Glomerular Filtration Rate; Humans; Indomet

1982
Increased monocyte-dependent suppression of polyclonal activation of B lymphocytes from cystinotic children.
    Pediatric nephrology (Berlin, Germany), 1991, Volume: 5, Issue:5

    Topics: Adolescent; B-Lymphocytes; Cells, Cultured; Child; Child, Preschool; Cystinosis; Dinoprostone; Human

1991