Page last updated: 2024-10-29

indomethacin and Cystic Periventricular Leukomalacia

indomethacin has been researched along with Cystic Periventricular Leukomalacia in 18 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia."8.91Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015)
"Cerebral palsy was found in 36 (9."6.68Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage. ( Allan, WC; Katz, KH; Makuch, RW; Ment, LR; Vohr, B, 1997)
"The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia."4.91Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015)
"Antenatal indomethacin may be associated with an increased risk of periventricular leukomalacia and necrotizing enterocolitis in premature infants and therefore should be used judiciously for tocolysis."4.84Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes. ( Amin, SB; Glantz, JC; Sinkin, RA, 2007)
"Cerebral palsy was found in 36 (9."2.68Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage. ( Allan, WC; Katz, KH; Makuch, RW; Ment, LR; Vohr, B, 1997)
"The aim of this study is to compare patent ductus arteriosus (PDA) management strategies and outcomes between the Neonatal Research Network of Japan (NRNJ) with proactive functional echocardiography and the Canadian Neonatal Network (CNN) with selective conventional echocardiography practice."1.42Patent ductus arteriosus management and outcomes in Japan and Canada: comparison of proactive and selective approaches. ( Fujimura, M; Isayama, T; Kusuda, S; Lee, SK; Mirea, L; Mori, R; Shah, PS, 2015)
"Chorioamnionitis was positively correlated with the risk, but did not reach statistical significance."1.33Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia. ( Itakura, A; Matsuzawa, K; Mizutani, S; Murata, Y; Okumura, A; Wakai, K, 2005)
"Indomethacin was given as part of tocolytic management to mothers with a high incidence of early rupture of membranes and preterm labour; and 76 fetuses were exposed to the drug as a result."1.28Cerebral lesions in preterm infants after tocolytic indomethacin. ( Baerts, W; Fetter, WP; Hop, WC; Sauer, PJ; Spritzer, R; Wallenburg, HC, 1990)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (16.67)18.2507
2000's7 (38.89)29.6817
2010's6 (33.33)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Shukla, VV1
Klinger, A1
Yazdi, S1
Rahman, AKMF1
Wright, S1
Barganier, A1
Ambalavanan, N1
Carlo, WA1
Ramani, M1
Bhat, R1
Zayek, M1
Maertens, P1
Eyal, F1
Isayama, T2
Kusuda, S2
Reichman, B1
Lee, SK2
Lehtonen, L1
Norman, M1
Adams, M1
Bassler, D1
Helenius, K1
Hakansson, S1
Yang, J1
Jain, A1
Shah, PS2
McNally, MA1
Soul, JS1
Hammers, AL2
Sanchez-Ramos, L2
Kaunitz, AM2
Mirea, L1
Mori, R1
Fujimura, M1
Hallman, M1
Pesonen, E1
Teramo, K1
Luu, TM2
Ment, LR4
Schneider, KC3
Katz, KH4
Allan, WC4
Vohr, BR3
Tucker, R1
Westerveld, M1
Makuch, RW2
Murata, Y1
Itakura, A1
Matsuzawa, K1
Okumura, A1
Wakai, K1
Mizutani, S1
Cordero, L1
Nankervis, CA1
Delooze, D1
Giannone, PJ1
Amin, SB1
Sinkin, RA1
Glantz, JC1
Sangem, M1
Asthana, S1
Amin, S1
Vohr, B1
Baerts, W1
Fetter, WP1
Hop, WC1
Wallenburg, HC1
Spritzer, R1
Sauer, PJ1
Haddad, J1
Messer, J1
Casanova, R1
Simeoni, U1
Willard, D1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial[NCT00033917]Phase 3630 participants (Actual)Interventional1989-09-30Completed
Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361]Early Phase 10 participants (Actual)Interventional2020-08-01Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

IVH at 5 Postnatal Days

Cranial ultrasounds were performed daily for the first 5 postnatal days; the main outcome measure was intraaventricular hemorrhage (IVH) at 5 days of age (NCT00033917)
Timeframe: at 5 days

InterventionIVH (Number)
Indomethacin25
Placebo40

Language Outcome

"Peabody Picture Vocabulary Test (PPVT) This is a semantic language test. The mean value is 100; standard deviation is 16 points. A higher score means better language; a lower score means poorer language.~There are no subscales to the PPVT. The measurement unit is points on a scale. A score < 70 indicates severely abnormal language function." (NCT00033917)
Timeframe: at 8 years

Interventionparticipants with PPVT score < 70 (Number)
Indomethacin - no IVH12
Indomethacin - IVH5
Placebo - no IVH24
Placebo - IVH7

Reviews

3 reviews available for indomethacin and Cystic Periventricular Leukomalacia

ArticleYear
Pharmacologic Prevention and Treatment of Neonatal Brain Injury.
    Clinics in perinatology, 2019, Volume: 46, Issue:2

    Topics: Adrenal Cortex Hormones; Allopurinol; Anesthetics, Inhalation; Anticonvulsants; Antioxidants; Cerebr

2019
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis.
    American journal of obstetrics and gynecology, 2015, Volume: 212, Issue:4

    Topics: Cerebral Ventricles; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infa

2015
Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes.
    American journal of obstetrics and gynecology, 2007, Volume: 197, Issue:5

    Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant

2007

Trials

4 trials available for indomethacin and Cystic Periventricular Leukomalacia

ArticleYear
Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age.
    Pediatrics, 2009, Volume: 123, Issue:3

    Topics: Brain Damage, Chronic; Cerebral Ventricles; Child; Child Behavior Disorders; Child, Preschool; Cogni

2009
Trajectories of receptive language development from 3 to 12 years of age for very preterm children.
    Pediatrics, 2009, Volume: 124, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; Cerebral Hemorrhage; Child; Child, P

2009
School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial.
    Pediatrics, 2003, Volume: 111, Issue:4 Pt 1

    Topics: Cerebral Hemorrhage; Cerebral Palsy; Cerebral Ventricles; Child; Cohort Studies; Developmental Disab

2003
Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage.
    Archives of pediatrics & adolescent medicine, 1997, Volume: 151, Issue:6

    Topics: Cerebral Hemorrhage; Cerebral Palsy; Cerebral Ventricles; Chorioamnionitis; Female; Gestational Age;

1997

Other Studies

11 other studies available for indomethacin and Cystic Periventricular Leukomalacia

ArticleYear
Prevention of severe brain injury in very preterm neonates: A quality improvement initiative.
    Journal of perinatology : official journal of the California Perinatal Association, 2022, Volume: 42, Issue:10

    Topics: Bicarbonates; Brain Injuries; Cerebral Hemorrhage; Humans; Indomethacin; Infant; Infant, Extremely P

2022
A single-dose indomethacin prophylaxis for reducing perinatal brain injury in extremely low birth weight infants: a non-inferiority analysis.
    Journal of perinatology : official journal of the California Perinatal Association, 2019, Volume: 39, Issue:11

    Topics: Alabama; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorrhage; Drug Administration Schedule;

2019
Neonatal Intensive Care Unit-Level Patent Ductus Arteriosus Treatment Rates and Outcomes in Infants Born Extremely Preterm.
    The Journal of pediatrics, 2020, Volume: 220

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Canada; Cardiovascular Surgical Procedures; Cerebral

2020
Patent ductus arteriosus management and outcomes in Japan and Canada: comparison of proactive and selective approaches.
    American journal of perinatology, 2015, Volume: 32, Issue:11

    Topics: Bronchopulmonary Dysplasia; Canada; Cerebral Hemorrhage; Comorbidity; Cyclooxygenase Inhibitors; Duc

2015
Reply: To PMID 25448524.
    American journal of obstetrics and gynecology, 2015, Volume: 213, Issue:6

    Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe

2015
Indomethacin as a tocolytic harmful to preterm infant.
    American journal of obstetrics and gynecology, 2015, Volume: 213, Issue:6

    Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe

2015
Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia.
    Brain & development, 2005, Volume: 27, Issue:1

    Topics: Apgar Score; Case-Control Studies; Causality; Cerebral Palsy; Chorioamnionitis; Comorbidity; Female;

2005
Indomethacin prophylaxis or expectant treatment of patent ductus arteriosus in extremely low birth weight infants?
    Journal of perinatology : official journal of the California Perinatal Association, 2007, Volume: 27, Issue:3

    Topics: Cerebral Hemorrhage; Comorbidity; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, N

2007
Multiple courses of indomethacin and neonatal outcomes in premature infants.
    Pediatric cardiology, 2008, Volume: 29, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therapy; Ductus Arteriosus, Patent; Human

2008
Cerebral lesions in preterm infants after tocolytic indomethacin.
    Developmental medicine and child neurology, 1990, Volume: 32, Issue:10

    Topics: Administration, Rectal; Brain; Brain Damage, Chronic; Cerebral Hemorrhage; Dose-Response Relationshi

1990
Indomethacin and ischemic brain injury in neonates.
    The Journal of pediatrics, 1990, Volume: 116, Issue:5

    Topics: Brain Ischemia; Diseases in Twins; Encephalomalacia; Female; Humans; Indomethacin; Infant, Newborn;

1990