indomethacin has been researched along with Cystic Periventricular Leukomalacia in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia." | 8.91 | Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015) |
| "Cerebral palsy was found in 36 (9." | 6.68 | Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage. ( Allan, WC; Katz, KH; Makuch, RW; Ment, LR; Vohr, B, 1997) |
| "The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia." | 4.91 | Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015) |
| "Antenatal indomethacin may be associated with an increased risk of periventricular leukomalacia and necrotizing enterocolitis in premature infants and therefore should be used judiciously for tocolysis." | 4.84 | Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes. ( Amin, SB; Glantz, JC; Sinkin, RA, 2007) |
| "Cerebral palsy was found in 36 (9." | 2.68 | Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage. ( Allan, WC; Katz, KH; Makuch, RW; Ment, LR; Vohr, B, 1997) |
| "The aim of this study is to compare patent ductus arteriosus (PDA) management strategies and outcomes between the Neonatal Research Network of Japan (NRNJ) with proactive functional echocardiography and the Canadian Neonatal Network (CNN) with selective conventional echocardiography practice." | 1.42 | Patent ductus arteriosus management and outcomes in Japan and Canada: comparison of proactive and selective approaches. ( Fujimura, M; Isayama, T; Kusuda, S; Lee, SK; Mirea, L; Mori, R; Shah, PS, 2015) |
| "Chorioamnionitis was positively correlated with the risk, but did not reach statistical significance." | 1.33 | Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia. ( Itakura, A; Matsuzawa, K; Mizutani, S; Murata, Y; Okumura, A; Wakai, K, 2005) |
| "Indomethacin was given as part of tocolytic management to mothers with a high incidence of early rupture of membranes and preterm labour; and 76 fetuses were exposed to the drug as a result." | 1.28 | Cerebral lesions in preterm infants after tocolytic indomethacin. ( Baerts, W; Fetter, WP; Hop, WC; Sauer, PJ; Spritzer, R; Wallenburg, HC, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Shukla, VV | 1 |
| Klinger, A | 1 |
| Yazdi, S | 1 |
| Rahman, AKMF | 1 |
| Wright, S | 1 |
| Barganier, A | 1 |
| Ambalavanan, N | 1 |
| Carlo, WA | 1 |
| Ramani, M | 1 |
| Bhat, R | 1 |
| Zayek, M | 1 |
| Maertens, P | 1 |
| Eyal, F | 1 |
| Isayama, T | 2 |
| Kusuda, S | 2 |
| Reichman, B | 1 |
| Lee, SK | 2 |
| Lehtonen, L | 1 |
| Norman, M | 1 |
| Adams, M | 1 |
| Bassler, D | 1 |
| Helenius, K | 1 |
| Hakansson, S | 1 |
| Yang, J | 1 |
| Jain, A | 1 |
| Shah, PS | 2 |
| McNally, MA | 1 |
| Soul, JS | 1 |
| Hammers, AL | 2 |
| Sanchez-Ramos, L | 2 |
| Kaunitz, AM | 2 |
| Mirea, L | 1 |
| Mori, R | 1 |
| Fujimura, M | 1 |
| Hallman, M | 1 |
| Pesonen, E | 1 |
| Teramo, K | 1 |
| Luu, TM | 2 |
| Ment, LR | 4 |
| Schneider, KC | 3 |
| Katz, KH | 4 |
| Allan, WC | 4 |
| Vohr, BR | 3 |
| Tucker, R | 1 |
| Westerveld, M | 1 |
| Makuch, RW | 2 |
| Murata, Y | 1 |
| Itakura, A | 1 |
| Matsuzawa, K | 1 |
| Okumura, A | 1 |
| Wakai, K | 1 |
| Mizutani, S | 1 |
| Cordero, L | 1 |
| Nankervis, CA | 1 |
| Delooze, D | 1 |
| Giannone, PJ | 1 |
| Amin, SB | 1 |
| Sinkin, RA | 1 |
| Glantz, JC | 1 |
| Sangem, M | 1 |
| Asthana, S | 1 |
| Amin, S | 1 |
| Vohr, B | 1 |
| Baerts, W | 1 |
| Fetter, WP | 1 |
| Hop, WC | 1 |
| Wallenburg, HC | 1 |
| Spritzer, R | 1 |
| Sauer, PJ | 1 |
| Haddad, J | 1 |
| Messer, J | 1 |
| Casanova, R | 1 |
| Simeoni, U | 1 |
| Willard, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial[NCT00033917] | Phase 3 | 630 participants (Actual) | Interventional | 1989-09-30 | Completed | ||
| Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361] | Early Phase 1 | 0 participants (Actual) | Interventional | 2020-08-01 | Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cranial ultrasounds were performed daily for the first 5 postnatal days; the main outcome measure was intraaventricular hemorrhage (IVH) at 5 days of age (NCT00033917)
Timeframe: at 5 days
| Intervention | IVH (Number) |
|---|---|
| Indomethacin | 25 |
| Placebo | 40 |
"Peabody Picture Vocabulary Test (PPVT) This is a semantic language test. The mean value is 100; standard deviation is 16 points. A higher score means better language; a lower score means poorer language.~There are no subscales to the PPVT. The measurement unit is points on a scale. A score < 70 indicates severely abnormal language function." (NCT00033917)
Timeframe: at 8 years
| Intervention | participants with PPVT score < 70 (Number) |
|---|---|
| Indomethacin - no IVH | 12 |
| Indomethacin - IVH | 5 |
| Placebo - no IVH | 24 |
| Placebo - IVH | 7 |
3 reviews available for indomethacin and Cystic Periventricular Leukomalacia
| Article | Year |
|---|---|
Pharmacologic Prevention and Treatment of Neonatal Brain Injury.
Topics: Adrenal Cortex Hormones; Allopurinol; Anesthetics, Inhalation; Anticonvulsants; Antioxidants; Cerebr | 2019 |
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis.
Topics: Cerebral Ventricles; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infa | 2015 |
Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes.
Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant | 2007 |
4 trials available for indomethacin and Cystic Periventricular Leukomalacia
| Article | Year |
|---|---|
Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age.
Topics: Brain Damage, Chronic; Cerebral Ventricles; Child; Child Behavior Disorders; Child, Preschool; Cogni | 2009 |
Trajectories of receptive language development from 3 to 12 years of age for very preterm children.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; Cerebral Hemorrhage; Child; Child, P | 2009 |
School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial.
Topics: Cerebral Hemorrhage; Cerebral Palsy; Cerebral Ventricles; Child; Cohort Studies; Developmental Disab | 2003 |
Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage.
Topics: Cerebral Hemorrhage; Cerebral Palsy; Cerebral Ventricles; Chorioamnionitis; Female; Gestational Age; | 1997 |
11 other studies available for indomethacin and Cystic Periventricular Leukomalacia
| Article | Year |
|---|---|
Prevention of severe brain injury in very preterm neonates: A quality improvement initiative.
Topics: Bicarbonates; Brain Injuries; Cerebral Hemorrhage; Humans; Indomethacin; Infant; Infant, Extremely P | 2022 |
A single-dose indomethacin prophylaxis for reducing perinatal brain injury in extremely low birth weight infants: a non-inferiority analysis.
Topics: Alabama; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorrhage; Drug Administration Schedule; | 2019 |
Neonatal Intensive Care Unit-Level Patent Ductus Arteriosus Treatment Rates and Outcomes in Infants Born Extremely Preterm.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Canada; Cardiovascular Surgical Procedures; Cerebral | 2020 |
Patent ductus arteriosus management and outcomes in Japan and Canada: comparison of proactive and selective approaches.
Topics: Bronchopulmonary Dysplasia; Canada; Cerebral Hemorrhage; Comorbidity; Cyclooxygenase Inhibitors; Duc | 2015 |
Reply: To PMID 25448524.
Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe | 2015 |
Indomethacin as a tocolytic harmful to preterm infant.
Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe | 2015 |
Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia.
Topics: Apgar Score; Case-Control Studies; Causality; Cerebral Palsy; Chorioamnionitis; Comorbidity; Female; | 2005 |
Indomethacin prophylaxis or expectant treatment of patent ductus arteriosus in extremely low birth weight infants?
Topics: Cerebral Hemorrhage; Comorbidity; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, N | 2007 |
Multiple courses of indomethacin and neonatal outcomes in premature infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therapy; Ductus Arteriosus, Patent; Human | 2008 |
Cerebral lesions in preterm infants after tocolytic indomethacin.
Topics: Administration, Rectal; Brain; Brain Damage, Chronic; Cerebral Hemorrhage; Dose-Response Relationshi | 1990 |
Indomethacin and ischemic brain injury in neonates.
Topics: Brain Ischemia; Diseases in Twins; Encephalomalacia; Female; Humans; Indomethacin; Infant, Newborn; | 1990 |