indomethacin has been researched along with Cystic Fibrosis in 13 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cystic fibrosis is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to altered ion transport, chronic infection, and excessive inflammation." | 5.33 | Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia. ( Clancy, JP; Li, Y; Parker, W; Wang, W, 2006) |
| "Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 5.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
| "Rectal biopsies from cystic fibrosis (CF) patients show defective cAMP-activated Cl(-) secretion and an inverse response of the short-circuit current (I(sc)) toward stimulation with carbachol (CCh)." | 3.70 | Defective cholinergic Cl(-) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients. ( Brandis, M; Greger, R; Kuehr, J; Kunzelmann, K; Mall, M; Seydewitz, HH; Wissner, A, 2000) |
| "Cystic fibrosis is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to altered ion transport, chronic infection, and excessive inflammation." | 1.33 | Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia. ( Clancy, JP; Li, Y; Parker, W; Wang, W, 2006) |
| "Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 1.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
| "Patients with Bartter's syndrome treated with PG synthetase inhibitors for 1 week respond with a profound drop in renin, together with a rise in prorenin." | 1.26 | Plasma "prorenin"-renin in Bartter's syndrome, cystic fibrosis, and chloride deficiency, and the effect of prostaglandin synthetase inhibition. ( Balfe, JW; Chan, LL; Halperin, ML; Osmond, DH, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, WJ | 1 |
| Goeckeler-Fried, JL | 1 |
| Havasi, V | 1 |
| Chiang, A | 1 |
| Rowe, SM | 1 |
| Plyler, ZE | 1 |
| Hong, JS | 1 |
| Mazur, M | 1 |
| Piazza, GA | 1 |
| Keeton, AB | 1 |
| White, EL | 1 |
| Rasmussen, L | 1 |
| Weissman, AM | 1 |
| Denny, RA | 1 |
| Brodsky, JL | 1 |
| Sorscher, EJ | 1 |
| Rodgers, HC | 1 |
| Pang, L | 1 |
| Holland, E | 1 |
| Corbett, L | 1 |
| Range, S | 1 |
| Knox, AJ | 1 |
| Li, Y | 1 |
| Wang, W | 1 |
| Parker, W | 1 |
| Clancy, JP | 1 |
| Chan, LL | 1 |
| Osmond, DH | 1 |
| Balfe, JW | 1 |
| Halperin, ML | 1 |
| Haschke, F | 1 |
| Götz, M | 1 |
| Parth, K | 1 |
| Popow, C | 1 |
| Schilling, R | 1 |
| Leung, AY | 1 |
| Wong, PY | 1 |
| Gabriel, SE | 1 |
| Yankaskas, JR | 1 |
| Boucher, RC | 2 |
| Kersting, U | 1 |
| Kersting, D | 1 |
| Spring, KR | 1 |
| Hardcastle, J | 1 |
| Hardcastle, PT | 1 |
| Klaren, PH | 1 |
| Taylor, CJ | 1 |
| White, SJ | 1 |
| Lloyd-Still, JD | 1 |
| Beno, DW | 1 |
| Uhing, MR | 1 |
| Kimura, RE | 1 |
| Mall, M | 1 |
| Wissner, A | 1 |
| Seydewitz, HH | 1 |
| Kuehr, J | 1 |
| Brandis, M | 1 |
| Greger, R | 1 |
| Kunzelmann, K | 1 |
| Ram, SJ | 1 |
| Weaver, ML | 1 |
| Kirk, KL | 1 |
| Holman, RT | 1 |
| Stutts, MJ | 1 |
| Knowles, MR | 1 |
| Cantley, L | 1 |
| Gatzy, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of High Omega-3 Fish Intake on Lipid Peroxidation[NCT01183520] | 30 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Cystic Fibrosis
| Article | Year |
|---|---|
Control of polyunsaturated acids in tissue lipids.
Topics: Acrodermatitis; alpha-Linolenic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Child; Crohn Dis | 1986 |
12 other studies available for indomethacin and Cystic Fibrosis
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids.
Topics: Arachidonic Acid; Bradykinin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygena | 2002 |
Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia.
Topics: Adenosine; Arachidonic Acid; Cell Membrane; Chloride Channels; Cystic Fibrosis; Cystic Fibrosis Tran | 2006 |
Plasma "prorenin"-renin in Bartter's syndrome, cystic fibrosis, and chloride deficiency, and the effect of prostaglandin synthetase inhibition.
Topics: Adolescent; Bartter Syndrome; Child; Child, Preschool; Chlorides; Cyclooxygenase Inhibitors; Cystic | 1981 |
Plasma aldosterone elevation due to renal sodium wasting in a boy with cystic fibrosis.
Topics: Aldosterone; Angiotensin II; Cystic Fibrosis; Humans; Indomethacin; Infant; Kidney; Male; Renin; Ren | 1981 |
cAMP- but not Ca(2+)-regulated Cl- conductance in the oviduct is defective in mouse model of cystic fibrosis.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Chloride Channels; Chlorides; Colforsin | 1995 |
Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells.
Topics: Absorption; Cell Line; Cell Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fi | 1993 |
The action of 5-hydroxytryptamine on normal and cystic fibrosis mouse colon: effects on secretion and intracellular calcium.
Topics: Acetylcholine; Action Potentials; Animals; Calcium; Colon; Cystic Fibrosis; Cytosol; Electric Stimul | 1999 |
Pancreatic enzymes and fibrosing colonopathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Cystic Fibrosis; Humans; Indomet | 1999 |
Defective cholinergic Cl(-) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients.
Topics: Adolescent; Adult; Biopsy; Carbachol; Child; Child, Preschool; Chlorides; Cholinergic Agonists; Chol | 2000 |
Regulation of Cl- permeability in normal and cystic fibrosis sweat duct cells.
Topics: Cell Membrane Permeability; Cells, Cultured; Chlorides; Cystic Fibrosis; Dinoprostone; Humans; Indom | 1990 |
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
Topics: Adenylyl Cyclases; Adolescent; Adult; Child; Cystic Fibrosis; Enzyme Activation; Epithelium; Female; | 1986 |