indomethacin has been researched along with Cystic Fibrosis of Pancreas in 13 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cystic fibrosis is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to altered ion transport, chronic infection, and excessive inflammation." | 5.33 | Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia. ( Clancy, JP; Li, Y; Parker, W; Wang, W, 2006) |
| "Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 5.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
| "Rectal biopsies from cystic fibrosis (CF) patients show defective cAMP-activated Cl(-) secretion and an inverse response of the short-circuit current (I(sc)) toward stimulation with carbachol (CCh)." | 3.70 | Defective cholinergic Cl(-) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients. ( Brandis, M; Greger, R; Kuehr, J; Kunzelmann, K; Mall, M; Seydewitz, HH; Wissner, A, 2000) |
| "Cystic fibrosis is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to altered ion transport, chronic infection, and excessive inflammation." | 1.33 | Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia. ( Clancy, JP; Li, Y; Parker, W; Wang, W, 2006) |
| "Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 1.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
| "Patients with Bartter's syndrome treated with PG synthetase inhibitors for 1 week respond with a profound drop in renin, together with a rise in prorenin." | 1.26 | Plasma "prorenin"-renin in Bartter's syndrome, cystic fibrosis, and chloride deficiency, and the effect of prostaglandin synthetase inhibition. ( Balfe, JW; Chan, LL; Halperin, ML; Osmond, DH, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, WJ | 1 |
| Goeckeler-Fried, JL | 1 |
| Havasi, V | 1 |
| Chiang, A | 1 |
| Rowe, SM | 1 |
| Plyler, ZE | 1 |
| Hong, JS | 1 |
| Mazur, M | 1 |
| Piazza, GA | 1 |
| Keeton, AB | 1 |
| White, EL | 1 |
| Rasmussen, L | 1 |
| Weissman, AM | 1 |
| Denny, RA | 1 |
| Brodsky, JL | 1 |
| Sorscher, EJ | 1 |
| Rodgers, HC | 1 |
| Pang, L | 1 |
| Holland, E | 1 |
| Corbett, L | 1 |
| Range, S | 1 |
| Knox, AJ | 1 |
| Li, Y | 1 |
| Wang, W | 1 |
| Parker, W | 1 |
| Clancy, JP | 1 |
| Chan, LL | 1 |
| Osmond, DH | 1 |
| Balfe, JW | 1 |
| Halperin, ML | 1 |
| Haschke, F | 1 |
| Götz, M | 1 |
| Parth, K | 1 |
| Popow, C | 1 |
| Schilling, R | 1 |
| Leung, AY | 1 |
| Wong, PY | 1 |
| Gabriel, SE | 1 |
| Yankaskas, JR | 1 |
| Boucher, RC | 2 |
| Kersting, U | 1 |
| Kersting, D | 1 |
| Spring, KR | 1 |
| Hardcastle, J | 1 |
| Hardcastle, PT | 1 |
| Klaren, PH | 1 |
| Taylor, CJ | 1 |
| White, SJ | 1 |
| Lloyd-Still, JD | 1 |
| Beno, DW | 1 |
| Uhing, MR | 1 |
| Kimura, RE | 1 |
| Mall, M | 1 |
| Wissner, A | 1 |
| Seydewitz, HH | 1 |
| Kuehr, J | 1 |
| Brandis, M | 1 |
| Greger, R | 1 |
| Kunzelmann, K | 1 |
| Ram, SJ | 1 |
| Weaver, ML | 1 |
| Kirk, KL | 1 |
| Holman, RT | 1 |
| Stutts, MJ | 1 |
| Knowles, MR | 1 |
| Cantley, L | 1 |
| Gatzy, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of High Omega-3 Fish Intake on Lipid Peroxidation[NCT01183520] | 30 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Control of polyunsaturated acids in tissue lipids.
Topics: Acrodermatitis; alpha-Linolenic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Child; Crohn Dis | 1986 |
12 other studies available for indomethacin and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids.
Topics: Arachidonic Acid; Bradykinin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygena | 2002 |
Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia.
Topics: Adenosine; Arachidonic Acid; Cell Membrane; Chloride Channels; Cystic Fibrosis; Cystic Fibrosis Tran | 2006 |
Plasma "prorenin"-renin in Bartter's syndrome, cystic fibrosis, and chloride deficiency, and the effect of prostaglandin synthetase inhibition.
Topics: Adolescent; Bartter Syndrome; Child; Child, Preschool; Chlorides; Cyclooxygenase Inhibitors; Cystic | 1981 |
Plasma aldosterone elevation due to renal sodium wasting in a boy with cystic fibrosis.
Topics: Aldosterone; Angiotensin II; Cystic Fibrosis; Humans; Indomethacin; Infant; Kidney; Male; Renin; Ren | 1981 |
cAMP- but not Ca(2+)-regulated Cl- conductance in the oviduct is defective in mouse model of cystic fibrosis.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Chloride Channels; Chlorides; Colforsin | 1995 |
Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells.
Topics: Absorption; Cell Line; Cell Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fi | 1993 |
The action of 5-hydroxytryptamine on normal and cystic fibrosis mouse colon: effects on secretion and intracellular calcium.
Topics: Acetylcholine; Action Potentials; Animals; Calcium; Colon; Cystic Fibrosis; Cytosol; Electric Stimul | 1999 |
Pancreatic enzymes and fibrosing colonopathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Cystic Fibrosis; Humans; Indomet | 1999 |
Defective cholinergic Cl(-) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients.
Topics: Adolescent; Adult; Biopsy; Carbachol; Child; Child, Preschool; Chlorides; Cholinergic Agonists; Chol | 2000 |
Regulation of Cl- permeability in normal and cystic fibrosis sweat duct cells.
Topics: Cell Membrane Permeability; Cells, Cultured; Chlorides; Cystic Fibrosis; Dinoprostone; Humans; Indom | 1990 |
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
Topics: Adenylyl Cyclases; Adolescent; Adult; Child; Cystic Fibrosis; Enzyme Activation; Epithelium; Female; | 1986 |