indomethacin has been researched along with Cystic Fibrosis of Pancreas in 13 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Excerpt | Relevance | Reference |
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"Cystic fibrosis is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to altered ion transport, chronic infection, and excessive inflammation." | 5.33 | Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia. ( Clancy, JP; Li, Y; Parker, W; Wang, W, 2006) |
"Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 5.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
"Rectal biopsies from cystic fibrosis (CF) patients show defective cAMP-activated Cl(-) secretion and an inverse response of the short-circuit current (I(sc)) toward stimulation with carbachol (CCh)." | 3.70 | Defective cholinergic Cl(-) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients. ( Brandis, M; Greger, R; Kuehr, J; Kunzelmann, K; Mall, M; Seydewitz, HH; Wissner, A, 2000) |
"Cystic fibrosis is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to altered ion transport, chronic infection, and excessive inflammation." | 1.33 | Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia. ( Clancy, JP; Li, Y; Parker, W; Wang, W, 2006) |
"Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 1.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
"Patients with Bartter's syndrome treated with PG synthetase inhibitors for 1 week respond with a profound drop in renin, together with a rise in prorenin." | 1.26 | Plasma "prorenin"-renin in Bartter's syndrome, cystic fibrosis, and chloride deficiency, and the effect of prostaglandin synthetase inhibition. ( Balfe, JW; Chan, LL; Halperin, ML; Osmond, DH, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (30.77) | 18.7374 |
1990's | 5 (38.46) | 18.2507 |
2000's | 3 (23.08) | 29.6817 |
2010's | 1 (7.69) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Chung, WJ | 1 |
Goeckeler-Fried, JL | 1 |
Havasi, V | 1 |
Chiang, A | 1 |
Rowe, SM | 1 |
Plyler, ZE | 1 |
Hong, JS | 1 |
Mazur, M | 1 |
Piazza, GA | 1 |
Keeton, AB | 1 |
White, EL | 1 |
Rasmussen, L | 1 |
Weissman, AM | 1 |
Denny, RA | 1 |
Brodsky, JL | 1 |
Sorscher, EJ | 1 |
Rodgers, HC | 1 |
Pang, L | 1 |
Holland, E | 1 |
Corbett, L | 1 |
Range, S | 1 |
Knox, AJ | 1 |
Li, Y | 1 |
Wang, W | 1 |
Parker, W | 1 |
Clancy, JP | 1 |
Chan, LL | 1 |
Osmond, DH | 1 |
Balfe, JW | 1 |
Halperin, ML | 1 |
Haschke, F | 1 |
Götz, M | 1 |
Parth, K | 1 |
Popow, C | 1 |
Schilling, R | 1 |
Leung, AY | 1 |
Wong, PY | 1 |
Gabriel, SE | 1 |
Yankaskas, JR | 1 |
Boucher, RC | 2 |
Kersting, U | 1 |
Kersting, D | 1 |
Spring, KR | 1 |
Hardcastle, J | 1 |
Hardcastle, PT | 1 |
Klaren, PH | 1 |
Taylor, CJ | 1 |
White, SJ | 1 |
Lloyd-Still, JD | 1 |
Beno, DW | 1 |
Uhing, MR | 1 |
Kimura, RE | 1 |
Mall, M | 1 |
Wissner, A | 1 |
Seydewitz, HH | 1 |
Kuehr, J | 1 |
Brandis, M | 1 |
Greger, R | 1 |
Kunzelmann, K | 1 |
Ram, SJ | 1 |
Weaver, ML | 1 |
Kirk, KL | 1 |
Holman, RT | 1 |
Stutts, MJ | 1 |
Knowles, MR | 1 |
Cantley, L | 1 |
Gatzy, JT | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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Effect of High Omega-3 Fish Intake on Lipid Peroxidation[NCT01183520] | 30 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for indomethacin and Cystic Fibrosis of Pancreas
Article | Year |
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Control of polyunsaturated acids in tissue lipids.
Topics: Acrodermatitis; alpha-Linolenic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Child; Crohn Dis | 1986 |
12 other studies available for indomethacin and Cystic Fibrosis of Pancreas
Article | Year |
---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids.
Topics: Arachidonic Acid; Bradykinin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygena | 2002 |
Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia.
Topics: Adenosine; Arachidonic Acid; Cell Membrane; Chloride Channels; Cystic Fibrosis; Cystic Fibrosis Tran | 2006 |
Plasma "prorenin"-renin in Bartter's syndrome, cystic fibrosis, and chloride deficiency, and the effect of prostaglandin synthetase inhibition.
Topics: Adolescent; Bartter Syndrome; Child; Child, Preschool; Chlorides; Cyclooxygenase Inhibitors; Cystic | 1981 |
Plasma aldosterone elevation due to renal sodium wasting in a boy with cystic fibrosis.
Topics: Aldosterone; Angiotensin II; Cystic Fibrosis; Humans; Indomethacin; Infant; Kidney; Male; Renin; Ren | 1981 |
cAMP- but not Ca(2+)-regulated Cl- conductance in the oviduct is defective in mouse model of cystic fibrosis.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Chloride Channels; Chlorides; Colforsin | 1995 |
Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells.
Topics: Absorption; Cell Line; Cell Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fi | 1993 |
The action of 5-hydroxytryptamine on normal and cystic fibrosis mouse colon: effects on secretion and intracellular calcium.
Topics: Acetylcholine; Action Potentials; Animals; Calcium; Colon; Cystic Fibrosis; Cytosol; Electric Stimul | 1999 |
Pancreatic enzymes and fibrosing colonopathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Cystic Fibrosis; Humans; Indomet | 1999 |
Defective cholinergic Cl(-) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients.
Topics: Adolescent; Adult; Biopsy; Carbachol; Child; Child, Preschool; Chlorides; Cholinergic Agonists; Chol | 2000 |
Regulation of Cl- permeability in normal and cystic fibrosis sweat duct cells.
Topics: Cell Membrane Permeability; Cells, Cultured; Chlorides; Cystic Fibrosis; Dinoprostone; Humans; Indom | 1990 |
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
Topics: Adenylyl Cyclases; Adolescent; Adult; Child; Cystic Fibrosis; Enzyme Activation; Epithelium; Female; | 1986 |