indomethacin has been researched along with Craniocerebral Trauma in 13 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Craniocerebral Trauma: Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "At 18 h post head trauma, rats were decapitated and tissue from the vicinity of the injury and from a corresponding area in the contralateral hemisphere was taken for specific gravity (SG) determination using linear gradient columns." | 5.27 | Dexamethasone and indomethacin do not affect brain edema following head injury in rats. ( Cotev, S; Davidson, E; Shapira, Y; Shohami, E; Weidenfeld, Y, 1988) |
| "The purpose of this study was to compare the effect of hyperventilation and indomethacin on cerebral circulation, metabolism and pressures in patients with acute severe head injury in order to see if indomethacin may act supplementary to hyperventilation." | 3.69 | CO(2) and indomethacin vasoreactivity in patients with head injury. ( Astrup, J; Bergholt, B; Cold, GE; Dahl, B; Jensen, K; Kjaersgaard, JO; Mosdal, B, 1996) |
| "Indomethacin, 25 mg, was given three times daily for six weeks." | 2.69 | Indomethacin versus radiation therapy for prophylaxis against heterotopic ossification in acetabular fractures: a randomised, prospective study. ( Anglen, JO; Goss, K; Moore, KD, 1998) |
| "To date, in the majority of instances, hemicrania continua appears to have arisen de novo, without any identifiable trigger." | 1.30 | Posttraumatic hemicrania continua. ( Lay, CL; Newman, LC, 1999) |
| "Whereas the articular complications of heterotopic ossification have been well documented, the vascular complications are less well known." | 1.29 | [Heterotopic ossification and vascular compression]. ( Brissot, R; Gallien, P; Le Bot, MP; Nicolas, B; Rivier, I; Robineau, S; Sarkis, S, 1994) |
| "A CT scan revealed a chronic subdural hematoma in the right frontotemporal region." | 1.28 | Cluster-like headache and head injury: case report. ( Angelini, A; Bozzao, L; Calisse, P; Catarci, T; Cerbo, R; De Vuono, G; Fiacco, F; Formisano, R, 1990) |
| "At 18 h post head trauma, rats were decapitated and tissue from the vicinity of the injury and from a corresponding area in the contralateral hemisphere was taken for specific gravity (SG) determination using linear gradient columns." | 1.27 | Dexamethasone and indomethacin do not affect brain edema following head injury in rats. ( Cotev, S; Davidson, E; Shapira, Y; Shohami, E; Weidenfeld, Y, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prakash, S | 1 |
| Shah, ND | 1 |
| Soni, RK | 1 |
| Lay, CL | 2 |
| Newman, LC | 1 |
| Gallien, P | 1 |
| Nicolas, B | 1 |
| Le Bot, MP | 1 |
| Robineau, S | 1 |
| Rivier, I | 1 |
| Sarkis, S | 1 |
| Brissot, R | 1 |
| Dahl, B | 1 |
| Bergholt, B | 2 |
| Cold, GE | 4 |
| Astrup, J | 4 |
| Mosdal, B | 1 |
| Jensen, K | 4 |
| Kjaersgaard, JO | 1 |
| Bundgaard, H | 1 |
| Imberti, R | 1 |
| Bellinzona, G | 1 |
| Ilardi, M | 1 |
| Bruzzone, P | 1 |
| Pricca, P | 1 |
| Harrigan, MR | 1 |
| Tuteja, S | 1 |
| Neudeck, BL | 1 |
| Moore, KD | 1 |
| Goss, K | 1 |
| Anglen, JO | 1 |
| Evans, RW | 1 |
| Ohrström, J | 2 |
| Formisano, R | 1 |
| Angelini, A | 1 |
| De Vuono, G | 1 |
| Calisse, P | 1 |
| Fiacco, F | 1 |
| Catarci, T | 1 |
| Bozzao, L | 1 |
| Cerbo, R | 1 |
| Shapira, Y | 1 |
| Davidson, E | 1 |
| Weidenfeld, Y | 1 |
| Cotev, S | 1 |
| Shohami, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| External Beam Radiotherapy as Prophylaxis for Heterotopic Ossification After Surgical Fixation of Acetabular Fractures: a Prospective, Randomized Feasibility Study[NCT04867278] | 60 participants (Anticipated) | Interventional | 2021-05-09 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for indomethacin and Craniocerebral Trauma
| Article | Year |
|---|---|
Secondary hemicrania continua: Case reports and a literature review.
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blood Sedimentation; Brain; Crani | 2009 |
Indomethacin in the management of elevated intracranial pressure: a review.
Topics: Animals; Body Temperature; Brain Edema; Cerebrovascular Circulation; Clinical Trials as Topic; Crani | 1997 |
1 trial available for indomethacin and Craniocerebral Trauma
| Article | Year |
|---|---|
Indomethacin versus radiation therapy for prophylaxis against heterotopic ossification in acetabular fractures: a randomised, prospective study.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cau | 1998 |
10 other studies available for indomethacin and Craniocerebral Trauma
| Article | Year |
|---|---|
Posttraumatic hemicrania continua.
Topics: Adult; Cardiovascular Agents; Craniocerebral Trauma; Diagnosis, Differential; Female; Headache; Huma | 1999 |
[Heterotopic ossification and vascular compression].
Topics: Adult; Craniocerebral Trauma; Etidronic Acid; Femoral Vein; Humans; Indomethacin; Male; Middle Aged; | 1994 |
CO(2) and indomethacin vasoreactivity in patients with head injury.
Topics: Adult; Aged; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Craniocerebral Trauma; Hum | 1996 |
Treatment of intracranial hypertension with indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Craniocerebral Trauma; Humans; Indomethacin; Intra | 1996 |
The use of indomethacin to treat acute rises of intracranial pressure and improve global cerebral perfusion in a child with head trauma.
Topics: Cerebrovascular Circulation; Child, Preschool; Craniocerebral Trauma; Female; Humans; Indomethacin; | 1997 |
Posttraumatic hemicrania continua?
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Craniocerebral Trauma; Female; Humans; Indomethacin; | 2000 |
Indomethacin in severe head injury.
Topics: Adult; Combined Modality Therapy; Craniocerebral Trauma; Drug Administration Schedule; Humans; Indom | 1990 |
Indomethacin in severe head injury.
Topics: Adult; Cerebrospinal Fluid Pressure; Craniocerebral Trauma; Humans; Indomethacin | 1990 |
Cluster-like headache and head injury: case report.
Topics: Administration, Rectal; Adult; Cluster Headache; Craniocerebral Trauma; Hematoma, Subdural; Humans; | 1990 |
Dexamethasone and indomethacin do not affect brain edema following head injury in rats.
Topics: Animals; Blood Pressure; Brain; Brain Edema; Craniocerebral Trauma; Dexamethasone; Indomethacin; Mal | 1988 |