indomethacin has been researched along with Coronary Disease in 82 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the influence of the thromboxane (TX) synthetase inhibitor HOE 944 (6-(5-Methylimidazol-1-yl)methyl-2-naphthoic acid-Hydrochloride), prostacyclin (PGI2) and indomethacin on reperfusion arrhythmias in isolated perfused ischemic rat hearts." | 7.67 | Influence of the thromboxane synthetase inhibitor HOE 944, prostacyclin and indomethacin on reperfusion arrhythmias, cardiodynamics and metabolism in isolated ischemic rat hearts. ( Beck, G; Lau, HH; Linz, W; Schökens, BA, 1988) |
| "Twenty-five patients with congestive heart failure and an ejection fraction less than 40% were evaluated." | 5.28 | Renal response to indomethacin in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Fisher, ML; Gottlieb, SS; Krichten, CM; Robinson, S, 1992) |
| "In parallel with experimental research into methods for salvage of ischemic myocardium after acute myocardial infarction (AMI) over the last decade, there has been a growing interest in prostaglandins (PG) and their inhibition by aspirin-like drugs or nonsteroidal anti-inflammatory drugs (NSAID)." | 4.76 | Prostaglandin inhibition and myocardial infarct size. ( Becker, LC; Jugdutt, BI, 1981) |
| "We investigated the influence of the thromboxane (TX) synthetase inhibitor HOE 944 (6-(5-Methylimidazol-1-yl)methyl-2-naphthoic acid-Hydrochloride), prostacyclin (PGI2) and indomethacin on reperfusion arrhythmias in isolated perfused ischemic rat hearts." | 3.67 | Influence of the thromboxane synthetase inhibitor HOE 944, prostacyclin and indomethacin on reperfusion arrhythmias, cardiodynamics and metabolism in isolated ischemic rat hearts. ( Beck, G; Lau, HH; Linz, W; Schökens, BA, 1988) |
| "Arrhythmias were produced by ouabain (2." | 3.67 | Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain. ( Ferrier, GR; Karmazyn, M; Moffat, MP, 1985) |
| "Twenty-five patients with congestive heart failure and an ejection fraction less than 40% were evaluated." | 1.28 | Renal response to indomethacin in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Fisher, ML; Gottlieb, SS; Krichten, CM; Robinson, S, 1992) |
| "Indomethacin treatment abolished the reduction of infarct size seen with defibrotide alone." | 1.28 | Defibrotide reduces infarct size in a rabbit model of experimental myocardial ischaemia and reperfusion. ( Thiemermann, C; Thomas, GR; Vane, JR, 1989) |
| "Pretreatment with iloprost, indomethacin, or vehicle began 10 min before ischemia." | 1.27 | Prostaglandins and myocardial noradrenaline overflow after sympathetic nerve stimulation during ischemia and reperfusion. ( Funke, K; Schrör, K, 1985) |
| "Ibuprofen was the most effective, producing an average recovery of 70% (P less than 0." | 1.27 | Contribution of prostaglandins to reperfusion-induced ventricular failure in isolated rat hearts. ( Karmazyn, M, 1986) |
| "Adenosine was extracted at rest, but during ischemia there was a significant release of its metabolite hypoxanthine, indicating increased myocardial breakdown of high-energy adenine nucleotides." | 1.27 | Coronary flow regulation in patients with ischemic heart disease: release of purines and prostacyclin and the effect of inhibitors of prostaglandin formation. ( Berglund, B; Edlund, A; Kaijser, L; Nowak, J; Patrono, C; Sollevi, A; van Dorne, D; Wennmalm, A, 1985) |
| "In 67 dogs with a 60-80% coronary stenosis produced by an external constricting plastic ring, blood flow measured with an electromagnetic flowmeter showed cyclical flow reductions of varying magnitude and duration, and then an abrupt return to control flow." | 1.26 | Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? ( Folts, JD; Gallagher, K; Rowe, GG, 1982) |
| "The effects of the inhibitors on reactive hyperemia resulting from 5-, 10-, 15-, and 20-second occlusions and the dilation resulting from 90-second exposure to 8% O2 were also examined." | 1.26 | Prostaglandins and the control of blood flow in the canine myocardium. ( Hintze, TH; Kaley, G, 1977) |
| "Pretreatment with indomethacin abolished the release of PGE2 and PGA2-like substances but no arachidonic acid and reduced the reactive hyperemic response in magnitude and duration." | 1.26 | Prostaglandin-like substances in coronary venous blood following myocardial ischemia. ( Folts, JD; Kraemer, RJ; Phernetton, TM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 66 (80.49) | 18.7374 |
| 1990's | 12 (14.63) | 18.2507 |
| 2000's | 4 (4.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lockowandt, U | 1 |
| Ritchie, A | 1 |
| Grossebener, M | 1 |
| Franco-Cereceda, A | 2 |
| James, DW | 1 |
| Cleland, LG | 1 |
| Robinson, CW | 1 |
| Leonello, PP | 1 |
| de Boer, AC | 1 |
| Genton, E | 1 |
| Turpie, AG | 1 |
| Kowey, PR | 1 |
| Verrier, RL | 1 |
| Lown, B | 1 |
| Handin, RI | 1 |
| Edlund, A | 3 |
| Berglund, B | 2 |
| Kaijser, L | 3 |
| Patrono, C | 2 |
| Sollevi, A | 2 |
| van Dorne, D | 2 |
| Wennmalm, A | 3 |
| Ogawa, K | 4 |
| Sakai, K | 1 |
| Ito, T | 1 |
| Watanabe, J | 1 |
| Satake, T | 4 |
| Meoni, S | 1 |
| Monaci, R | 1 |
| Aiken, JW | 2 |
| Shebuski, RJ | 2 |
| Miller, OV | 1 |
| Gorman, RR | 2 |
| Dusting, GJ | 2 |
| Nolan, RD | 2 |
| Woodman, OL | 1 |
| Martin, TJ | 1 |
| Tada, M | 1 |
| Esumi, K | 1 |
| Yamagishi, M | 1 |
| Kuzuya, T | 1 |
| Matsuda, H | 1 |
| Abe, H | 1 |
| Uchida, Y | 1 |
| Murao, S | 1 |
| Karmazyn, M | 5 |
| Carlsson, I | 1 |
| Eriksson, S | 1 |
| Nowak, J | 2 |
| Bailey, IA | 1 |
| Carey, F | 1 |
| Haworth, D | 1 |
| Smith, HJ | 1 |
| Hintze, TH | 2 |
| Vatner, SF | 1 |
| Mullane, KM | 1 |
| Moncada, S | 1 |
| Miyazaki, Y | 2 |
| Kotaka, K | 2 |
| Sugiyama, S | 2 |
| Ozawa, T | 2 |
| Jugdutt, BI | 1 |
| Becker, LC | 1 |
| Folts, JD | 2 |
| Gallagher, K | 1 |
| Rowe, GG | 1 |
| Gorman, MW | 2 |
| Sparks, HV | 2 |
| Halawa, B | 1 |
| Mazurek, W | 1 |
| Friedman, PL | 1 |
| Brown, EJ | 1 |
| Gunther, S | 1 |
| Alexander, RW | 2 |
| Barry, WH | 1 |
| Mudge, GH | 1 |
| Grossman, W | 1 |
| Jablonická, K | 1 |
| Kovalcík, V | 1 |
| Spodick, DH | 1 |
| Steele, P | 1 |
| Rainwater, J | 1 |
| Ito, I | 1 |
| Enomoto, I | 1 |
| Hashimoto, H | 1 |
| Kai, I | 1 |
| Carr, FK | 2 |
| Goldfarb, RD | 2 |
| Fuller, CM | 1 |
| Raizner, AE | 1 |
| Chahine, RA | 1 |
| Nahormek, P | 1 |
| Ishimori, T | 1 |
| Verani, M | 1 |
| Nitishin, A | 1 |
| Mokotoff, D | 1 |
| Luchi, RJ | 1 |
| Moschos, CB | 1 |
| Haider, B | 1 |
| Escobinas, AJ | 1 |
| Gandhi, A | 1 |
| Regan, TJ | 1 |
| Sulpice, T | 1 |
| Boucher, F | 1 |
| Pucheu, S | 1 |
| de Leiris, J | 1 |
| Bednarcyzk, EM | 1 |
| Furniss, SM | 1 |
| Green, JA | 1 |
| Munger, MA | 1 |
| Limbruno, U | 1 |
| Petronio, AS | 1 |
| Amoroso, G | 1 |
| Baglini, R | 1 |
| Paterni, G | 1 |
| Merelli, A | 1 |
| Mariotti, R | 1 |
| Mariani, M | 1 |
| Gupte, SA | 1 |
| Okada, T | 1 |
| Tateyama, M | 1 |
| Ochi, R | 1 |
| Madan, ZM | 1 |
| Sainani, GS | 1 |
| Boss, GR | 1 |
| Seegmiller, JE | 1 |
| Loegering, DJ | 1 |
| Malik, AB | 1 |
| Horrobin, DF | 1 |
| Oka, M | 1 |
| Manku, MS | 1 |
| Ally, AI | 1 |
| Karmali, RA | 1 |
| Morgan, RO | 1 |
| Cunnane, SC | 1 |
| Isakson, PC | 1 |
| Raz, A | 1 |
| Hsueh, W | 1 |
| Needleman, P | 1 |
| Kent, KM | 1 |
| Pisano, JJ | 1 |
| Keiser, HR | 1 |
| Cooper, T | 1 |
| Kaley, G | 1 |
| Ogletree, ML | 2 |
| Flynn, JT | 1 |
| Feola, M | 1 |
| Lefer, AM | 3 |
| Staszewka-Barczak, J | 1 |
| Ferreira, SH | 1 |
| Vane, JR | 2 |
| Kraemer, RJ | 1 |
| Phernetton, TM | 1 |
| Woditsch, I | 2 |
| Schrör, K | 3 |
| Gottlieb, SS | 1 |
| Robinson, S | 1 |
| Krichten, CM | 1 |
| Fisher, ML | 1 |
| Altman, J | 1 |
| Dulas, D | 1 |
| Bache, RJ | 1 |
| Berti, F | 2 |
| Rossoni, G | 2 |
| Galli, G | 1 |
| Magni, F | 1 |
| Mantovani, M | 1 |
| Calvani, AB | 1 |
| Porta, R | 1 |
| Prino, G | 1 |
| Monti, F | 1 |
| Schiariti, M | 1 |
| Dawodu, AA | 1 |
| Lanti, M | 1 |
| Pulvirenti, G | 1 |
| Terracciano, CM | 1 |
| Evangelista, E | 1 |
| Puddu, PE | 1 |
| Marino, B | 1 |
| Campa, PP | 1 |
| Kirkebøen, KA | 1 |
| Aksnes, G | 1 |
| Ilebekk, A | 1 |
| Pieper, GM | 1 |
| Tio, RA | 1 |
| van Gilst, WH | 1 |
| Rett, K | 1 |
| Wolters, K | 1 |
| Dietze, GJ | 1 |
| Wesseling, H | 1 |
| Tillmanns, H | 1 |
| Neumann, FJ | 1 |
| Parekh, N | 1 |
| Dorigo, O | 1 |
| Tiefenbacher, C | 1 |
| Zimmermann, R | 1 |
| Steinhausen, M | 1 |
| Kübler, W | 1 |
| Funke, K | 1 |
| Silverman, KJ | 1 |
| Lund, DP | 1 |
| Zetter, BR | 1 |
| Lainey, LL | 1 |
| Shahood, JA | 1 |
| Freiman, DG | 1 |
| Folkman, J | 1 |
| Barger, AC | 1 |
| Ertl, G | 1 |
| Bauer, B | 1 |
| Gaudron, P | 1 |
| Kochsiek, K | 1 |
| Ito, BR | 1 |
| Roth, DM | 1 |
| Chenoweth, DE | 1 |
| Engler, RL | 1 |
| Thames, MD | 1 |
| Minisi, AJ | 1 |
| Zucker, IH | 1 |
| Panzenbeck, MJ | 1 |
| Hackley, JF | 1 |
| Haiderzad, K | 1 |
| Thiemermann, C | 1 |
| Thomas, GR | 1 |
| Carlsson, L | 1 |
| Abrahamsson, T | 1 |
| Nichols, WW | 2 |
| Mehta, JL | 1 |
| Donnelly, WH | 1 |
| Lawson, D | 1 |
| Thompson, L | 1 |
| ter Riet, M | 1 |
| Linz, W | 1 |
| Lau, HH | 1 |
| Beck, G | 1 |
| Schökens, BA | 1 |
| Björnsson, OG | 1 |
| Kobayashi, K | 1 |
| Williamson, JR | 1 |
| Pacold, I | 1 |
| Hwang, MH | 1 |
| Lawless, CE | 1 |
| Diamond, P | 1 |
| Scanlon, PJ | 1 |
| Loeb, HS | 1 |
| Omini, C | 1 |
| Folco, G | 1 |
| Daffonchio, L | 1 |
| Viganó, T | 1 |
| Tondo, C | 1 |
| Northover, BJ | 2 |
| Wangler, RD | 1 |
| DeWitt, DF | 1 |
| Moffat, MP | 2 |
| Ferrier, GR | 1 |
| Forman, MB | 1 |
| Uderman, H | 1 |
| Jackson, EK | 1 |
| Roy, L | 1 |
| Bostick, D | 1 |
| Robertson, D | 1 |
| Robertson, RM | 1 |
| Wargovich, T | 1 |
| Mehta, J | 1 |
| Pepine, CJ | 1 |
| Conti, CR | 1 |
| Grover, GJ | 1 |
| Weiss, HR | 1 |
| Odegaard, AE | 1 |
| Gormsen, J | 1 |
| Andersen, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multivariable Assessment of Coronary Artery Disease Using Cardiac CT Imaging[NCT00857792] | 120 participants (Actual) | Interventional | 2009-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00857792)
Timeframe: 3 months
| Intervention | % accurately detected perfusion defects (Number) |
|---|---|
| Open Label | 78 |
3 reviews available for indomethacin and Coronary Disease
| Article | Year |
|---|---|
Chemistry, measurement, and clinical significance of platelet specific proteins.
Topics: Aspirin; Beta-Globulins; beta-Thromboglobulin; Blood Coagulation; Blood Coagulation Factors; Blood P | 1982 |
Prostaglandin inhibition and myocardial infarct size.
Topics: Acute Disease; Animals; Aspirin; Coronary Disease; Humans; Ibuprofen; Indomethacin; Models, Biologic | 1981 |
Hyperuricemia and gout. Classification, complications and management.
Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Human | 1979 |
3 trials available for indomethacin and Coronary Disease
| Article | Year |
|---|---|
Evaluation of the indomethacin-nitroglycerin interaction with positron-emission tomography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Coronary Circulation; Coronary Disease; Double-Blind Method | 1997 |
Effects of indomethacin on coronary hemodynamics, myocardial metabolism and anginal threshold in coronary artery disease.
Topics: Administration, Oral; Angina Pectoris; Animals; Cardiac Pacing, Artificial; Clinical Trials as Topic | 1986 |
Effects of indomethacin on systemic and coronary hemodynamics in patients with coronary artery disease.
Topics: Adult; Aspirin; Blood Pressure; Coronary Circulation; Coronary Disease; Cyclooxygenase Inhibitors; F | 1985 |
76 other studies available for indomethacin and Coronary Disease
| Article | Year |
|---|---|
Endothelin and effects of endothelin-receptor activation in the mammary and radial artery.
Topics: Biomarkers; Coronary Artery Bypass; Coronary Disease; Endothelin-1; Endothelium, Vascular; Female; H | 2004 |
Reversible renal failure: associated with treatment with a beta-adrenergic receptor blocking drug and non-steroidal anti-inflammatory drugs.
Topics: Acute Kidney Injury; Adrenergic beta-Antagonists; Anti-Inflammatory Agents; Arthritis, Rheumatoid; C | 1982 |
Influence of intracoronary platelet aggregation on ventricular electrical properties during partial coronary artery stenosis.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Cardiac Complexes, Premature; Coronary Circula | 1983 |
Release of adenosine and prostacyclin from ischemic human hearts.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Adult; Aged; Coronary Circulation; Coronary Disease; Epopro | 1983 |
Effects of selective thromboxane synthetase inhibitor and indomethacin on prostacyclin and thromboxane A2 from ischemic canine heart.
Topics: 6-Ketoprostaglandin F1 alpha; Acrylates; Animals; Coronary Circulation; Coronary Disease; Dogs; Hear | 1983 |
[Prostaglandins, indomethacin and the physiopathology of various systems].
Topics: Cardiovascular System; Coronary Disease; Drug Interactions; Humans; Indomethacin; Inflammation; Kidn | 1984 |
Endogenous prostacyclin contributes to the efficacy of a thromboxane synthetase inhibitor for preventing coronary artery thrombosis.
Topics: Acrylates; Animals; Aspirin; Blood Platelets; Coronary Disease; Cyclic AMP; Cyclooxygenase Inhibitor | 1981 |
Prostacyclin produced by the pericardium and its influence on coronary vascular tone.
Topics: Angiotensin II; Animals; Arachidonic Acids; Cattle; Coronary Circulation; Coronary Disease; Coronary | 1983 |
Reduction of prostacyclin synthesis as a possible cause of transient flow reduction in a partially constricted canine coronary artery.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Dog | 1984 |
Reduction of enzyme release from reperfused ischemic hearts by steroidal and non-steroidal prostaglandin synthesis inhibitors.
Topics: Animals; Aspirin; Coronary Disease; Creatine Kinase; Dexamethasone; Heart; Hydrocortisone; Indometha | 1983 |
Central and peripheral haemodynamic effects of non-steroidal anti-inflammatory drugs in man.
Topics: Adult; Anti-Inflammatory Agents; Coronary Circulation; Coronary Disease; Hemodynamics; Humans; Indom | 1984 |
Effects of vascular trauma and transient myocardial ischaemia on coronary venous prostaglandin levels in the dog.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Catheterization; Coronary Disease; Coronary Vessels; Dogs; Fe | 1983 |
Reactive dilation of large coronary arteries in conscious dogs.
Topics: Aminophylline; Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Circulation; Coronary | 1984 |
The salvage of ischaemic myocardium by BW755C in anaesthetised dogs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Cor | 1982 |
Mechanism of mitochondrial damage after coronary reperfusion.
Topics: Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Dinoprost; Dogs; Female; Indometh | 1982 |
Mechanism of reperfusion arrhythmia prostaglandin as a washout metabolite.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Coronary Disease; Dinoprost; Dogs; Female; Indo | 1982 |
Stimulation of prostacyclin release from the epicardium of anaesthetized dogs.
Topics: Angiotensins; Animals; Arachidonic Acids; Coronary Circulation; Coronary Disease; Dogs; Epoprostenol | 1981 |
Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation?
Topics: Animals; Aspirin; Constriction, Pathologic; Coronary Angiography; Coronary Circulation; Coronary Dis | 1982 |
Progressive coronary vasoconstriction during relative ischemia in canine myocardium.
Topics: Adenosine; Animals; Arterial Occlusive Diseases; Coronary Disease; Dogs; Hemodynamics; Indomethacin; | 1982 |
[Interactions of digoxin and the nonsteroidal anti-inflammatory drugs, acetylsalicylic acid and nifedipine].
Topics: Adult; Arthritis; Aspirin; Coronary Disease; Digoxin; Drug Interactions; Humans; Indomethacin; Male; | 1982 |
Coronary vasoconstrictor effect of indomethacin in patients with coronary-artery disease.
Topics: Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Humans; Indomethacin; Midd | 1981 |
[Pharmacologically influenced hypocalcemia in tourniquet shock in rats (author's transl)].
Topics: Animals; Coronary Disease; Glucocorticoids; Histamine; Indomethacin; Male; Rats; Rats, Inbred Strain | 1981 |
Effects of indomethacin during experimental myocardial ischemia.
Topics: Animals; Coronary Disease; Dogs; Humans; Indomethacin; Necrosis | 1981 |
Relationship of plasma anti-heparin activity and platelet survival time in coronary disease.
Topics: Aspirin; Blood Coagulation Factors; Blood Platelets; Cell Survival; Coronary Disease; Dipyridamole; | 1980 |
Increase of coronary flow and levels of PGE1 and PGF2 alpha from the ischemic area of experimental myocardial infarction.
Topics: Animals; Blood Glucose; Coronary Circulation; Coronary Disease; Dogs; Fatty Acids, Nonesterified; In | 1980 |
Ischemia-induced canine myocardial lysosome labilization: the role of endogenous prostaglandins and cyclic nucleotides.
Topics: Acid Phosphatase; Animals; Coronary Disease; Disease Models, Animal; Dogs; Indomethacin; Intracellul | 1980 |
Exercise-induced coronary arterial spasm: angiographic demonstration, documentation of ischemia by myocardial scintigraphy and results of pharmacologic intervention.
Topics: Angina Pectoris, Variant; Coronary Disease; Exercise Test; Humans; Indomethacin; Male; Middle Aged; | 1980 |
Chronic use of aspirin versus indomethacin during non-thrombotic myocardial ischemia: effects on survival.
Topics: Animals; Aspirin; Coronary Disease; Dogs; Electrocardiography; Hemodynamics; Indomethacin; Male; Pot | 1980 |
Contribution of leukocyte infiltration to lipoperoxidation occurring in the non-ischemic region of the rat heart submitted to permanent left coronary artery occlusion.
Topics: Animals; Constriction; Coronary Disease; Fluorescent Antibody Technique; Indomethacin; Inflammation; | 1994 |
The impact of coronary artery disease on the coronary vasomotor response to nonionic contrast media.
Topics: Aged; Cardiovascular Agents; Contrast Media; Coronary Angiography; Coronary Circulation; Coronary Di | 2000 |
Activation of TxA2/PGH2 receptors and protein kinase C contribute to coronary dysfunction in superoxide treated rat hearts.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium Channel Blocker | 2000 |
Effects of cyclo-oxygenase and thromboxane synthetase inhibitors on right atrial prostaglandins.
Topics: Aspirin; Benzofurans; Coronary Artery Bypass; Coronary Disease; Culture Techniques; Cyclooxygenase I | 2000 |
Prevention of blockage of partially obstructed coronary arteries with prostacyclin correlates with inhibition of platelet aggregation.
Topics: Adenosine Diphosphate; Administration, Topical; Animals; Arteries; Coronary Disease; Dogs; Epoproste | 1979 |
The effect of indomethacin on cardiovascular and lysosomal mechanisms during experimental myocardial ischemia.
Topics: Animals; Coronary Disease; Coronary Vessels; Creatine Kinase; Dogs; Hemodynamics; Indomethacin; Lyso | 1978 |
Changes in coronary vascular resistance associated with prolonged hypoxia in isolated rat hearts: a possible role of prostaglandins.
Topics: Aging; Animals; Aspirin; Chloroquine; Coronary Circulation; Coronary Disease; In Vitro Techniques; I | 1979 |
Lipases and prostaglandin biosynthesis.
Topics: Adenosine Triphosphate; Angiotensins; Animals; Arachidonic Acids; Bradykinin; Coronary Disease; Indo | 1978 |
Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Cyclooxygenase Inhibit | 1975 |
Prostaglandins and the control of blood flow in the canine myocardium.
Topics: Adenosine; Angiotensin II; Animals; Arachidonic Acids; Blood Pressure; Coronary Circulation; Coronar | 1977 |
Early prostaglandin release from the ischemic myocardium in the dog.
Topics: Animals; Blood Pressure; Cathepsins; Coronary Disease; Coronary Vessels; Creatine Kinase; Dogs; Elec | 1977 |
Influence of nonsteroidal anti-inflammatory agents on myocardial ischemia in the cat.
Topics: Animals; Anti-Inflammatory Agents; Aorta, Thoracic; Aspirin; Blood Pressure; Cats; Coronary Disease; | 1976 |
An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia.
Topics: Animals; Blood Pressure; Bradykinin; Coronary Disease; Dogs; Drug Synergism; Female; Femoral Artery; | 1976 |
Prostaglandin-like substances in coronary venous blood following myocardial ischemia.
Topics: Animals; Arachidonic Acids; Blood Pressure; Chromatography, Thin Layer; Coronary Circulation; Corona | 1976 |
Prostacyclin rather than endogenous nitric oxide is a tissue protective factor in myocardial ischemia.
Topics: Animals; Arginine; Coronary Circulation; Coronary Disease; Creatine Kinase; Epoprostenol; Heart; Ind | 1992 |
Renal response to indomethacin in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
Topics: Adult; Aged; Blood Pressure; Cardiomyopathy, Dilated; Coronary Disease; Female; Glomerular Filtratio | 1992 |
Effect of cyclooxygenase blockade on blood flow through well-developed coronary collateral vessels.
Topics: Animals; Arachidonic Acid; Collateral Circulation; Coronary Circulation; Coronary Disease; Coronary | 1992 |
Defibrotide has antiischemic activity in perfused rabbit hearts, preventing tissue Ca++ overloading.
Topics: Animals; Calcium; Coronary Disease; Dinoprostone; Epoprostenol; Fibrinolytic Agents; Indomethacin; M | 1992 |
Endogenous prostacyclin preserves myocardial function and endothelium-derived nitric oxide formation in myocardial ischemia.
Topics: Animals; Arginine; Blood Pressure; Coronary Circulation; Coronary Disease; Creatine Kinase; Epoprost | 1992 |
[The prevention of an excitation-conduction block during acute myocardial ischemia: is there a role for prostacyclin or for histamine?].
Topics: Acute Disease; Animals; Antihypertensive Agents; Coronary Disease; Dimethyl Sulfoxide; Diuretics; Dr | 1991 |
Reduced prostaglandin release from the stunned porcine heart--significance for attenuated reactive hyperaemia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Blood Volume; Coronary Circulation; Coronary | 1991 |
Arachidonic acid causes postischemic dysfunction in control but not diabetic hearts.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Catalase; Coronary Disease; Diabetic Angiopathies; Epo | 1990 |
The effects of bradykinin and the ischemic isolated rat heart.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Coronary Circulation; Coro | 1990 |
Pharmacologic effects on coronary microvessels during myocardial ischaemia.
Topics: Animals; Blood Flow Velocity; Capillary Permeability; Coronary Circulation; Coronary Disease; Corona | 1990 |
Prostaglandins and myocardial noradrenaline overflow after sympathetic nerve stimulation during ischemia and reperfusion.
Topics: Animals; Coronary Disease; Electric Stimulation; Epoprostenol; Hemodynamics; Iloprost; Indomethacin; | 1985 |
Angiogenic activity of adipose tissue.
Topics: Adipose Tissue; Animals; Cornea; Coronary Disease; Indomethacin; Neovascularization, Pathologic; Pro | 1988 |
Coronary effects of neuropeptides in dogs: role of cyclooxygenase products as mediators.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Indomethacin; Neuropeptide Y; Neuropeptides; | 1989 |
Thromboxane is produced in response to intracoronary infusions of complement C5a in pigs. Cyclooxygenase blockade does not reduce the myocardial ischemia and leukocyte accumulation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Complement C5a | 1989 |
Prostaglandins and CGRP release from cardiac sensory nerves.
Topics: Alprostadil; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Disease; Epop | 1989 |
Reflex responses to myocardial ischemia and reperfusion. Role of prostaglandins.
Topics: Afferent Pathways; Animals; Coronary Disease; Dogs; Heart; Indomethacin; Kidney; Mechanoreceptors; M | 1989 |
Baroreflex inhibition during coronary occlusion is mediated by prostaglandins.
Topics: Animals; Blood Pressure; Coronary Disease; Dogs; Female; Indomethacin; Kidney; Male; Pressoreceptors | 1989 |
Defibrotide reduces infarct size in a rabbit model of experimental myocardial ischaemia and reperfusion.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Electrocardiography; Heart Rate; He | 1989 |
Ramiprilat attenuates the local release of noradrenaline in the ischemic myocardium.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Coronary Disease; Cre | 1989 |
Reduction in coronary vasodilator reserve following coronary occlusion and reperfusion in anesthetized dog: role of endothelium-derived relaxing factor, myocardial neutrophil infiltration and prostaglandins.
Topics: Acetylcholine; Animals; Biological Factors; Coronary Circulation; Coronary Disease; Coronary Vessels | 1988 |
Influence of the thromboxane synthetase inhibitor HOE 944, prostacyclin and indomethacin on reperfusion arrhythmias, cardiodynamics and metabolism in isolated ischemic rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Epoprostenol; Heart; Imidazoles; In Vitro Technique | 1988 |
Contribution of prostaglandins to reperfusion-induced ventricular failure in isolated rat hearts.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Coronary Circulation; Coronary Disease; Cyclooxygena | 1986 |
Modulation of coronary flow rate and cardiac contractility by the divalent cation ionophore A23187 and inhibitors of the cyclooxygenase and 5-lipoxygenase pathways: development of heterogeneous patterns of myocardial ischemia.
Topics: Animals; Arachidonate Lipoxygenases; Calcimycin; Coronary Circulation; Coronary Disease; Cyclooxygen | 1988 |
Defibrotide, an antithrombotic substance which prevents myocardial contracture in ischemic rabbit heart.
Topics: Animals; Coronary Disease; Dinoprostone; Epoprostenol; Fibrinolytic Agents; In Vitro Techniques; Ind | 1987 |
A protective effect of sulphinpyrazone against coronary occlusion-induced shortening of myocardial refractory periods in the rat.
Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Coronary Disease; Electrocardiography; Heart | 1986 |
Electrical changes produced by injury to the rat myocardium in vitro and the protective effects of certain antiarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Coronary Disease; Electric Stimulation; Heart Conduction S | 1987 |
Progressive vasomotor changes in ischaemic myocardium.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Disease; Dogs; Guinea Pigs; Humans; Indomethacin; | 1985 |
Coronary flow regulation in patients with ischemic heart disease: release of purines and prostacyclin and the effect of inhibitors of prostaglandin formation.
Topics: Adenosine; Adult; Aged; Coronary Circulation; Coronary Disease; Epoprostenol; Humans; Ibuprofen; Ind | 1985 |
Toxic properties of arachidonic acid on normal, ischemic and reperfused hearts. Indirect evidence for free radical involvement.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Coronary Disease; Creatine Kinase; Fre | 1985 |
Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Arrhythmias, Cardiac; As | 1985 |
Reduction in blood flow in normal and narrowed coronary arteries of dogs by leukotriene C4.
Topics: Animals; Blood Pressure; Constriction, Pathologic; Coronary Circulation; Coronary Disease; Dogs; Dos | 1985 |
Effect of ibuprofen and indomethacin on the O2 supply/consumption balance in ischemic rabbit myocardium.
Topics: Animals; Anti-Inflammatory Agents; Coronary Circulation; Coronary Disease; Heart; Ibuprofen; Indomet | 1985 |
[Interaction between anticoagulants and indomethacin].
Topics: Aged; Blood Coagulation; Coronary Disease; Drug Synergism; Female; Humans; Indomethacin; Male; Middl | 1974 |
[Incidence of thrombosis and the status of coagulation in ischaemic heart disease].
Topics: Acute Disease; Aspirin; Blood Coagulation; Chronic Disease; Coronary Disease; Depression, Chemical; | 1974 |