indomethacin has been researched along with Coronary Artery Disease in 9 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To address this hypothesis, we used dosing with nimesulide, which inhibited COX-2 ex vivo, depressed urinary 2,3 dinor 6-keto PGF(1alpha) by approximately 60% but had no effect on thromboxane formation by platelets, which only express COX-1." | 1.31 | Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. ( FitzGerald, GA; Li, H; Praticò, D; Tillmann, C; Zhang, ZB, 2001) |
| "During oxygen deficiency, control preparations showed a maximal hyperpolarization of delta V = 10." | 1.28 | Membrane physiological reactions of human arteriosclerotic coronary arteries to hypoxia. ( Grote, J; Rückborn, K; Schnalke, F; Siegel, G, 1992) |
| "Indomethacin (10(-5) M) was present to prevent possible interference from endogenously formed prostaglandins." | 1.27 | Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries. ( Alheid, U; Förstermann, U; Frölich, JC; Haverich, A; Mügge, A, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kok, MG | 1 |
| Mandolini, C | 1 |
| Moerland, PD | 1 |
| de Ronde, MW | 1 |
| Sondermeijer, BM | 1 |
| Halliani, A | 1 |
| Nieuwland, R | 1 |
| Cipollone, F | 1 |
| Creemers, EE | 1 |
| Meijers, JC | 1 |
| Pinto-Sietsma, SJ | 1 |
| Zhang, Y | 1 |
| Wahl, LM | 1 |
| Praticò, D | 1 |
| Tillmann, C | 1 |
| Zhang, ZB | 1 |
| Li, H | 1 |
| FitzGerald, GA | 1 |
| Siegel, G | 1 |
| Rückborn, K | 1 |
| Schnalke, F | 1 |
| Grote, J | 1 |
| Dhawan, V | 3 |
| Ganguly, NK | 3 |
| Majumdar, S | 2 |
| Chakravarti, RN | 3 |
| Nalini, K | 1 |
| Wahi, S | 1 |
| Meenakshi, S | 1 |
| Murohara, T | 1 |
| Yasue, H | 1 |
| Ohgushi, M | 1 |
| Sakaino, N | 1 |
| Jougasaki, M | 1 |
| Förstermann, U | 1 |
| Mügge, A | 1 |
| Alheid, U | 1 |
| Haverich, A | 1 |
| Frölich, JC | 1 |
9 other studies available for indomethacin and Coronary Artery Disease
| Article | Year |
|---|---|
Low miR-19b-1-5p expression in isolated platelets after aspirin use is related to aspirin insensitivity.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Blood Plate | 2016 |
Synergistic enhancement of cytokine-induced human monocyte matrix metalloproteinase-1 by C-reactive protein and oxidized LDL through differential regulation of monocyte chemotactic protein-1 and prostaglandin E2.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; C-Reactive Protein; Cell Movement; | 2006 |
Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; | 2001 |
Membrane physiological reactions of human arteriosclerotic coronary arteries to hypoxia.
Topics: Calcium Channels; Coronary Artery Disease; Coronary Vessels; Epoprostenol; Humans; Hypoxia; In Vitro | 1992 |
Effect of indomethacin on serum lipids, lipoproteins, prostaglandins and the extent and severity of atherosclerosis in rhesus monkeys.
Topics: Animals; Apoproteins; Arteriosclerosis; Coronary Artery Disease; Diet, Atherogenic; Hyperlipidemias; | 1992 |
Free radicals in myocardial injury: experimental and clinical studies.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Animals; Calcium; Coronary Artery Disease; Endothelial Gr | 1992 |
Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries.
Topics: Aging; Animals; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Endothe | 1991 |
Short-term therapy of atherosclerosis with low dose indomethacin: an experimental study.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Body Weight; Cholesterol; Coronary Artery Disease; Diet, Athe | 1990 |
Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries.
Topics: Acetylcholine; Adolescent; Adult; Biological Products; Bradykinin; Calcimycin; Coronary Artery Disea | 1988 |