Page last updated: 2024-10-29

indomethacin and Compensatory Hyperinsulinemia

indomethacin has been researched along with Compensatory Hyperinsulinemia in 5 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.

Research Excerpts

ExcerptRelevanceReference
"Metformin treatment improved these alterations."1.38Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. ( Akamine, EH; Carvalho, MH; Filgueira, FP; Fortes, ZB; Hagihara, GN; Lobato, NS; Pariz, JR; Tostes, RC, 2012)
"Pretreatment with indomethacin (3 mg/kg body weight), however, completely blocked the interleukin-1-induced stimulation of insulin secretion."1.28Indomethacin reverses interleukin-1-induced hyperinsulinemia in conscious and freely moving rats. ( Kumei, Y; Namiki, M; Okumura, T; Takasugi, Y; Uehara, A, 1991)
"Moreover, the hyperinsulinemia is mediated in part by prostaglandins just like the well-studied febrile response."1.28Central interleukin 1-elicited hyperinsulinemia is mediated by prostaglandins but not autonomics. ( Cornell, RP, 1989)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lobato, NS1
Filgueira, FP1
Hagihara, GN1
Akamine, EH1
Pariz, JR1
Tostes, RC1
Carvalho, MH1
Fortes, ZB1
Kashiwagi, A1
Shinozaki, K1
Nishio, Y1
Okamura, T1
Toda, N1
Kikkawa, R1
Schusdziarra, V1
Rouiller, D1
Unger, RH1
Uehara, A1
Okumura, T1
Kumei, Y1
Takasugi, Y1
Namiki, M1
Cornell, RP1

Other Studies

5 other studies available for indomethacin and Compensatory Hyperinsulinemia

ArticleYear
Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.
    Life sciences, 2012, Jan-30, Volume: 90, Issue:5-6

    Topics: Acetylcholine; Animals; Blood Pressure; Body Weight; Disease Models, Animal; Dyslipidemias; Epoprost

2012
Free radical production in endothelial cells as a pathogenetic factor for vascular dysfunction in the insulin resistance state.
    Diabetes research and clinical practice, 1999, Volume: 45, Issue:2-3

    Topics: Acetylcholine; Animals; Calcimycin; Endothelium, Vascular; Free Radicals; Fructose; Hyperinsulinism;

1999
Sympathectomy and prostaglandin deficiency do not prevent gastrogenic hyperglycaemia and hyperinsulinaemia.
    Acta endocrinologica, 1979, Volume: 92, Issue:4

    Topics: Animals; Blood Glucose; Dogs; Food; Gastrins; Glucagon; Hydrogen-Ion Concentration; Hydroxydopamines

1979
Indomethacin reverses interleukin-1-induced hyperinsulinemia in conscious and freely moving rats.
    European journal of pharmacology, 1991, Jan-03, Volume: 192, Issue:1

    Topics: Anesthesia; Animals; Dose-Response Relationship, Drug; Hyperinsulinism; Indomethacin; Insulin; Inter

1991
Central interleukin 1-elicited hyperinsulinemia is mediated by prostaglandins but not autonomics.
    The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 2

    Topics: Acetophenones; Adrenocorticotropic Hormone; Animals; Atropine; Autonomic Nervous System; Body Temper

1989