indomethacin has been researched along with Colorectal Neoplasms in 38 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A substantial body of evidence from rodent colon carcinogenesis models, in vitro experiments with human colorectal cancer cells and limited clinical observations in humans suggest that the non-steroidal anti-inflammatory drug indomethacin has anti-colorectal cancer activity." | 8.82 | Activity of the non-steroidal anti-inflammatory drug indomethacin against colorectal cancer. ( Gardner, SH; Hawcroft, G; Hull, MA, 2003) |
| "Ingestion of DON mycotoxin at concentrations representative of human real-world exposure worsened the development of indomethacin-induced enteritis and colitis-associated CRC in mice." | 8.31 | Low dose dietary contamination with deoxynivalenol mycotoxin exacerbates enteritis and colorectal cancer in mice. ( Beury, D; Body-Malapel, M; Caboche, S; Desai, MS; Djouina, M; Dubuquoy, L; Hot, D; Launay, D; Lecointe, K; Steimle, A; Vignal, C; Waxin, C, 2023) |
| "To evaluate, for the first time, the efficacy of copper-indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT-116 colorectal cancer cell line, gastrointestinal permeability, mitochondrial oxidative damage, and renal toxicity in rat models." | 7.76 | Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. ( Bonin, AM; Davies, NM; Dillon, CT; Fukuda, C; Hambley, TW; Lay, PA; Teng, XW; Yáñez, JA, 2010) |
| "Nonsteroidal anti-inflammatory drugs such as indomethacin (IN) can exert anti-colorectal cancer (CRC) activity through cyclooxygenase independent mechanism, but the exactly biological mechanism is not completely known." | 7.73 | Preliminary proteomic analysis of indomethacin's effect on tumor transplanted with colorectal cancer cell in nude mice. ( Chen, ZC; Wang, HM; Wang, YJ; Xiao, ZQ; Zhang, GY, 2006) |
| "The mechanism of the anticolorectal cancer activity of the nonsteroidal anti-inflammatory drug indomethacin is poorly understood." | 7.72 | Activation of peroxisome proliferator-activated receptor gamma does not explain the antiproliferative activity of the nonsteroidal anti-inflammatory drug indomethacin on human colorectal cancer cells. ( Gardner, SH; Hawcroft, G; Hull, MA, 2003) |
| " Using subtractive hybridization, we previously identified a novel member of the transforming growth factor-beta superfamily that has antitumorigenic activity from indomethacin-treated HCT-116 human colorectal cancer cells." | 7.72 | Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells. ( Baek, SJ; Eling, TE; Jain, AK; Moore, SM; Yamaguchi, K, 2004) |
| "Indomethacin-induced G(1) arrest and apoptosis of human colorectal cancer (CRC) cells is associated with a dose-dependent decrease in beta-catenin protein levels." | 7.71 | Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. ( Albanese, C; D'Amico, M; Hawcroft, G; Hull, MA; Markham, AF; Pestell, RG, 2002) |
| "Indomethacin and NGX6 inhibit the proliferation and invasiveness of HT-29 and SW620 colon cancer cells by attenuating the WNT/ss-catenin signaling pathway." | 5.35 | Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway. ( Guo, Q; Lian, P; Liao, M; Shen, S; Wang, X; Wu, M; Xiao, Z, 2009) |
| "Indomethacin can inhibit the growth of COX-negative human colon cancer cells both in vitro and in vivo, which indirectly suggests that indomethacin exerts its anti-tumor effect at least partly independent of the cyclooxygenase inhibitory profile." | 5.32 | [Effect of indomethacin on human colorectal cancer cells HCT116 and SW480]. ( Wang, HM; Zhang, GY, 2004) |
| "A substantial body of evidence from rodent colon carcinogenesis models, in vitro experiments with human colorectal cancer cells and limited clinical observations in humans suggest that the non-steroidal anti-inflammatory drug indomethacin has anti-colorectal cancer activity." | 4.82 | Activity of the non-steroidal anti-inflammatory drug indomethacin against colorectal cancer. ( Gardner, SH; Hawcroft, G; Hull, MA, 2003) |
| "Ingestion of DON mycotoxin at concentrations representative of human real-world exposure worsened the development of indomethacin-induced enteritis and colitis-associated CRC in mice." | 4.31 | Low dose dietary contamination with deoxynivalenol mycotoxin exacerbates enteritis and colorectal cancer in mice. ( Beury, D; Body-Malapel, M; Caboche, S; Desai, MS; Djouina, M; Dubuquoy, L; Hot, D; Launay, D; Lecointe, K; Steimle, A; Vignal, C; Waxin, C, 2023) |
| "To evaluate, for the first time, the efficacy of copper-indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT-116 colorectal cancer cell line, gastrointestinal permeability, mitochondrial oxidative damage, and renal toxicity in rat models." | 3.76 | Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. ( Bonin, AM; Davies, NM; Dillon, CT; Fukuda, C; Hambley, TW; Lay, PA; Teng, XW; Yáñez, JA, 2010) |
| "To determine the role of 14-3-3 in colorectal cancer apoptosis induced by nonsteroidal anti-inflammatory drugs (NSAIDs), we evaluated the effects of sulindac on 14-3-3epsilon protein expression in colorectal cancer cells." | 3.74 | Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon. ( Ghelani, D; Liou, JY; Wu, KK; Yeh, S, 2007) |
| "Nonsteroidal anti-inflammatory drugs such as indomethacin (IN) can exert anti-colorectal cancer (CRC) activity through cyclooxygenase independent mechanism, but the exactly biological mechanism is not completely known." | 3.73 | Preliminary proteomic analysis of indomethacin's effect on tumor transplanted with colorectal cancer cell in nude mice. ( Chen, ZC; Wang, HM; Wang, YJ; Xiao, ZQ; Zhang, GY, 2006) |
| "The mechanism of the anticolorectal cancer activity of the nonsteroidal anti-inflammatory drug indomethacin is poorly understood." | 3.72 | Activation of peroxisome proliferator-activated receptor gamma does not explain the antiproliferative activity of the nonsteroidal anti-inflammatory drug indomethacin on human colorectal cancer cells. ( Gardner, SH; Hawcroft, G; Hull, MA, 2003) |
| " Using subtractive hybridization, we previously identified a novel member of the transforming growth factor-beta superfamily that has antitumorigenic activity from indomethacin-treated HCT-116 human colorectal cancer cells." | 3.72 | Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells. ( Baek, SJ; Eling, TE; Jain, AK; Moore, SM; Yamaguchi, K, 2004) |
| "Indomethacin-induced G(1) arrest and apoptosis of human colorectal cancer (CRC) cells is associated with a dose-dependent decrease in beta-catenin protein levels." | 3.71 | Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. ( Albanese, C; D'Amico, M; Hawcroft, G; Hull, MA; Markham, AF; Pestell, RG, 2002) |
| "Prostaglandins support progression of colorectal cancer by several mechanisms." | 2.75 | Receptor and enzyme expression for prostanoid metabolism in colorectal cancer related to tumor tissue PGE2. ( Andersson, M; Gustafsson, A; Lagerstedt, K; Lönnroth, C; Lundholm, K; Nordgren, S, 2010) |
| "Indomethacin and NGX6 inhibit the proliferation and invasiveness of HT-29 and SW620 colon cancer cells by attenuating the WNT/ss-catenin signaling pathway." | 1.35 | Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway. ( Guo, Q; Lian, P; Liao, M; Shen, S; Wang, X; Wu, M; Xiao, Z, 2009) |
| "Indomethacin can inhibit the growth of COX-negative human colon cancer cells both in vitro and in vivo, which indirectly suggests that indomethacin exerts its anti-tumor effect at least partly independent of the cyclooxygenase inhibitory profile." | 1.32 | [Effect of indomethacin on human colorectal cancer cells HCT116 and SW480]. ( Wang, HM; Zhang, GY, 2004) |
| "NSAIDs act on human colorectal cancer cells via different mechanisms." | 1.31 | The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. ( Hawcroft, G; Hull, MA; Smith, ML, 2000) |
| "COX-2 is at elevated levels in human colorectal cancers and in tumors and polyps of mouse models of colorectal cancer." | 1.31 | Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. ( Baek, SJ; Eling, TE; Hsi, LC, 2000) |
| "Studies from hereditary and sporadic colorectal cancer (CRC) patients suggest that NSAIDs may interfere with initiating steps of carcinogenesis, i." | 1.31 | The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. ( Dihlmann, S; Siermann, A; von Knebel Doeberitz, M, 2001) |
| "We have determined the dose-response relationship between sulindac administration and inhibition of tumour growth in the rat." | 1.30 | Sulindac inhibits colorectal tumour growth, but not prostaglandin synthesis in the rat. ( Charalambous, D; O'Brien, PE; Skinner, SA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (18.42) | 18.2507 |
| 2000's | 22 (57.89) | 29.6817 |
| 2010's | 8 (21.05) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Djouina, M | 1 |
| Waxin, C | 1 |
| Caboche, S | 1 |
| Lecointe, K | 1 |
| Steimle, A | 1 |
| Beury, D | 1 |
| Desai, MS | 1 |
| Hot, D | 1 |
| Dubuquoy, L | 1 |
| Launay, D | 1 |
| Vignal, C | 1 |
| Body-Malapel, M | 1 |
| Sanchez-Vazquez, B | 1 |
| Lee, JB | 1 |
| Strimaite, M | 1 |
| Buanz, A | 1 |
| Bailey, R | 1 |
| Gershkovich, P | 1 |
| Pasparakis, G | 1 |
| Williams, GR | 1 |
| Lönnroth, C | 4 |
| Andersson, M | 4 |
| Asting, AG | 1 |
| Nordgren, S | 4 |
| Lundholm, K | 4 |
| Kwok, AH | 1 |
| Wang, Y | 1 |
| Ho, WS | 1 |
| Zrieki, A | 1 |
| Farinotti, R | 1 |
| Buyse, M | 1 |
| Guo, Q | 1 |
| Wu, M | 1 |
| Lian, P | 1 |
| Liao, M | 1 |
| Xiao, Z | 1 |
| Wang, X | 1 |
| Shen, S | 1 |
| Réti, A | 1 |
| Pap, E | 1 |
| Adleff, V | 1 |
| Jeney, A | 1 |
| Kralovánszky, J | 1 |
| Budai, B | 1 |
| Bonin, AM | 1 |
| Yáñez, JA | 1 |
| Fukuda, C | 1 |
| Teng, XW | 1 |
| Dillon, CT | 1 |
| Hambley, TW | 1 |
| Lay, PA | 1 |
| Davies, NM | 1 |
| Gustafsson, A | 1 |
| Lagerstedt, K | 2 |
| Zhang, YJ | 1 |
| Bao, YJ | 1 |
| Dai, Q | 1 |
| Yang, WY | 1 |
| Cheng, P | 1 |
| Zhu, LM | 1 |
| Wang, BJ | 1 |
| Jiang, FH | 1 |
| Hawcroft, G | 4 |
| Gardner, SH | 2 |
| Hull, MA | 4 |
| Bottone, FG | 2 |
| Martinez, JM | 1 |
| Collins, JB | 1 |
| Afshari, CA | 1 |
| Eling, TE | 5 |
| Jain, AK | 1 |
| Moore, SM | 1 |
| Yamaguchi, K | 1 |
| Baek, SJ | 3 |
| Wang, HM | 2 |
| Zhang, GY | 3 |
| Moon, Y | 1 |
| McEntee, MF | 1 |
| Wang, YJ | 1 |
| Xiao, ZQ | 1 |
| Chen, ZC | 1 |
| Wang, J | 1 |
| Li, XH | 1 |
| Liou, JY | 1 |
| Ghelani, D | 1 |
| Yeh, S | 1 |
| Wu, KK | 1 |
| Yoshinaga, M | 1 |
| Murao, H | 1 |
| Kitamura, Y | 1 |
| Koga, K | 1 |
| Tsuruta, S | 1 |
| Igarashi, H | 1 |
| Nakamura, K | 1 |
| Takayanagi, R | 1 |
| Loveridge, CJ | 1 |
| MacDonald, AD | 1 |
| Thoms, HC | 1 |
| Dunlop, MG | 1 |
| Stark, LA | 1 |
| Arvidsson, A | 1 |
| Brevinge, H | 1 |
| Siemer, S | 1 |
| Kriener, S | 1 |
| König, J | 1 |
| Remberger, K | 1 |
| Issinger, OG | 1 |
| Sandler, RS | 1 |
| Hara, A | 1 |
| Yoshimi, N | 1 |
| Niwa, M | 1 |
| Ino, N | 1 |
| Mori, H | 1 |
| Kamitani, H | 1 |
| Geller, M | 1 |
| Eling, T | 1 |
| Charalambous, D | 1 |
| Skinner, SA | 1 |
| O'Brien, PE | 1 |
| Giardina, C | 1 |
| Boulares, H | 1 |
| Inan, MS | 1 |
| Smith, ML | 1 |
| Hsi, LC | 1 |
| Zhang, L | 1 |
| Yu, J | 1 |
| Park, BH | 1 |
| Kinzler, KW | 1 |
| Vogelstein, B | 1 |
| Dihlmann, S | 1 |
| Siermann, A | 1 |
| von Knebel Doeberitz, M | 1 |
| Chen, YC | 1 |
| Tsai, SH | 1 |
| Shen, SC | 1 |
| Lin, JK | 1 |
| Lee, WR | 1 |
| Bhandari, P | 1 |
| Shashidhara, LS | 1 |
| D'Amico, M | 1 |
| Albanese, C | 1 |
| Markham, AF | 1 |
| Pestell, RG | 1 |
| Wilson, LC | 1 |
| Lee, CH | 1 |
| Hamblin, TJ | 1 |
2 reviews available for indomethacin and Colorectal Neoplasms
| Article | Year |
|---|---|
Activity of the non-steroidal anti-inflammatory drug indomethacin against colorectal cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antineoplastic Combined Che | 2003 |
Aspirin and other nonsteroidal anti-inflammatory agents in the prevention of colorectal cancer.
Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli; Adult; Animals; Anti-Inflammatory Agents, Non-S | 1996 |
3 trials available for indomethacin and Colorectal Neoplasms
| Article | Year |
|---|---|
Receptor and enzyme expression for prostanoid metabolism in colorectal cancer related to tumor tissue PGE2.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colorectal Neoplasms; Dinoprostone | 2010 |
Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Mo | 2008 |
Indomethacin, ranitidine, and interleukin-2 in melanoma.
Topics: Colorectal Neoplasms; Drug Therapy, Combination; Humans; Indomethacin; Interleukin-2; Kidney Neoplas | 1992 |
33 other studies available for indomethacin and Colorectal Neoplasms
| Article | Year |
|---|---|
Low dose dietary contamination with deoxynivalenol mycotoxin exacerbates enteritis and colorectal cancer in mice.
Topics: Animals; Colitis; Colorectal Neoplasms; Diet; Enteritis; Humans; Indomethacin; Mice; Mycotoxins | 2023 |
Solid lipid nanoparticles self-assembled from spray dried microparticles.
Topics: Administration, Oral; Aerosols; Caco-2 Cells; Cell Survival; Colorectal Neoplasms; Delayed-Action Pr | 2019 |
Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Celecoxib; Colorectal Neoplasms; Female; | 2014 |
Cytotoxic and pro-oxidative effects of Imperata cylindrica aerial part ethyl acetate extract in colorectal cancer in vitro.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, N | 2016 |
Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2008 |
Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; beta Catenin; Cell Adhesion; Cell Communication; | 2009 |
Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Pro | 2010 |
Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats.
Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Carcinogens; | 2010 |
mTOR signaling is involved in indomethacin and nimesulide suppression of colorectal cancer cell growth via a COX-2 independent pathway.
Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Cycloox | 2011 |
Downregulation of Prominin 1/CD133 expression in colorectal cancer by NSAIDs following short-term preoperative treatment.
Topics: AC133 Antigen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Bioma | 2012 |
Activation of peroxisome proliferator-activated receptor gamma does not explain the antiproliferative activity of the nonsteroidal anti-inflammatory drug indomethacin on human colorectal cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Blotting, Western; Cell Division; Co | 2003 |
Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Northern; Blotting, Western; Cell Divi | 2003 |
Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells.
Topics: Actins; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Cell Line, Tumor; Chromatograph | 2004 |
[Effect of indomethacin on human colorectal cancer cells HCT116 and SW480].
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Colorectal Neoplasms; Cyclooxygenas | 2004 |
Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Colorectal Neopl | 2005 |
Preliminary proteomic analysis of indomethacin's effect on tumor transplanted with colorectal cancer cell in nude mice.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Electrophoresis, Gel, Two-Dimen | 2006 |
Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells.
Topics: Apoptosis; CCN Intercellular Signaling Proteins; Colorectal Neoplasms; Cyclooxygenase Inhibitors; HC | 2006 |
Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon.
Topics: 14-3-3 Proteins; Adenoviridae; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-Associated De | 2007 |
The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Arachidonate 15-Lipoxygenase; beta Catenin | 2007 |
The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB.
Topics: Active Transport, Cell Nucleus; Apoptosis; Cell Line, Tumor; Cell Nucleus; Colorectal Neoplasms; Cyc | 2008 |
Influence of indomethacin and difluoromethylornithine on human tumour growth in nude mice.
Topics: Animals; Cell Division; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Eflornithine; Humans | 1995 |
Apoptosis induced by NS-398, a selective cyclooxygenase-2 inhibitor, in human colorectal cancer cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Colorectal Neoplasms; Cyclooxygen | 1997 |
Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation.
Topics: Apoptosis; Arachidonate 15-Lipoxygenase; Butyrates; Butyric Acid; Caco-2 Cells; Cell Differentiation | 1998 |
Sulindac inhibits colorectal tumour growth, but not prostaglandin synthesis in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Colorectal Neoplasms; Dose-Response Relatio | 1998 |
NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antioxidants; Apoptosis; Butyra | 1999 |
The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; beta Catenin; Cell Division; Colorectal | 2000 |
Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells.
Topics: Apoptosis; Blotting, Western; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Cyclooxyge | 2000 |
Role of BAX in the apoptotic response to anticancer agents.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antimetabolites, Antineoplastic; A | 2000 |
The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; beta Catenin; Colorectal Neoplasms; Cyclin D1; Cyc | 2001 |
Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
Topics: Acetylcysteine; Arsenites; Blotting, Northern; Blotting, Western; Colorectal Neoplasms; Curcumin; Cy | 2001 |
Studies on human colon cancer gene APC by targeted expression in Drosophila.
Topics: Adenomatous Polyposis Coli Protein; Animals; Animals, Genetically Modified; Antineoplastic Agents; A | 2001 |
Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.
Topics: Acetylcysteine; beta Catenin; Blotting, Western; Colorectal Neoplasms; Cyclin D1; Cytoskeletal Prote | 2002 |
Dual function of nonsteroidal anti-inflammatory drugs (NSAIDs): inhibition of cyclooxygenase and induction of NSAID-activated gene.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Colorectal Neoplasms; Cyclooxygenase 1; C | 2002 |