indomethacin has been researched along with Colonic Neoplasms in 109 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study implies the therapeutic effect of IND and juglone [JUG] against colon carcinogenesis, without gastric ulceration - an adverse side effect of IND." | 8.02 | Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis. ( Devaraj, H; Seetha, A; Sudhandiran, G, 2021) |
| " We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice." | 7.72 | Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004) |
| " The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers." | 7.67 | [Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987) |
| "The anti-inflammatory drug indomethacin was tested for antitumor activity against transplantable mouse colon adenocarcinoma 38 (colon 38)." | 7.66 | Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin. ( Goto, A; Narisawa, T; Sano, M; Sato, M; Takahashi, T, 1983) |
| " Flurbiprofen, indomethacin and other NSAIDs stimulated 15-PGDH activity in colon cancer HT29 cells as well as in lung cancer A549 cells and glioblastoma T98G cells." | 4.87 | Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). ( Chi, X; Tai, HH; Tong, M, 2011) |
| " This study implies the therapeutic effect of IND and juglone [JUG] against colon carcinogenesis, without gastric ulceration - an adverse side effect of IND." | 4.02 | Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis. ( Devaraj, H; Seetha, A; Sudhandiran, G, 2021) |
| " We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice." | 3.72 | Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004) |
| "To assess the putative involvement of NF-kappaB and pro-inflammatory cytokines in the pathogenesis of cancer cachexia and the therapeutic efficacy of indomethacin (IND) on cachexia." | 3.72 | Role of NF-kappaB and cytokine in experimental cancer cachexia. ( Jiang, J; Jiang, ZW; Li, JS; Li, N; Tian, J; Zhou, W, 2003) |
| " In our study, the effects of TNF-alpha, inhibitors of arachidonic acid (AA) metabolism (baicalein, BA; indomethacin, INDO; niflumic acid, NA; nordihydroguaiaretic acid, NDGA), and/or their combinations on undifferentiated or sodium butyrate (NaBt)-differentiated human colon adenocarcinoma HT-29 cells were compared." | 3.72 | The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status. ( Hofmanová, J; Kovaríková, M; Kozubík, A; Soucek, K, 2004) |
| "To assess the putative involvement of NF-kappaB and pro-inflammatory cytokines in the pathogenesis of cancer cachexia and the therapeutic efficacy of indomethacin (IND) on cachexia." | 3.72 | [Role of NF-kappa B in cancer cachexia]. ( Jiang, J; Jiang, ZW; Li, JS; Li, N; Zhou, W, 2004) |
| " In this paper, we present the effect of indomethacin on growth inhibition and alterations in the expression of several genes involved in cell cycle and apoptosis in CaCo-2 colon adenocarcinoma cells." | 3.71 | Effect of the nonsteroidal anti-inflammatory drug indomethacin on proliferation and apoptosis of colon carcinoma cells. ( Kapitanović, S; Kovacević, D; Kralj, M; Lukac, J; Pavelić, K; Spaventi, S, 2001) |
| "The clonogenic hybrid spheroid assay has been used to determine the toxicity of 5-fluorouracil (5-FU), alone or in combination with indomethacin, in LoVo cells (a human colon adenocarcinoma line)." | 3.70 | Clonogenic inactivation of colon cancer-derived cells treated with 5-fluorouracil and indomethacin in hybrid spheroids. ( Djordjevic, B; Lange, CS; Rotman, M; Schwartz, MS, 1998) |
| "The effect of the polyunsaturated fatty acids (PUFAs) linoleic acid (LA) and arachidonic acid (AA) on the growth of two murine colon adenocarcinoma cell lines (MAC26 and MAC13) has been determined both in vitro and in vivo." | 3.69 | Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo. ( Hussey, HJ; Tisdale, MJ, 1994) |
| " We evaluated the effect of aspirin (ASA) and three other structurally unrelated NSAIDs (indomethacin, naproxen, and piroxicam) on cell proliferation, cell cycle phase distribution, and the development of apoptosis in HT-29 colon adenocarcinoma cells in vitro." | 3.69 | Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. ( Koutsos, MI; Qiao, L; Rigas, B; Shiff, SJ, 1996) |
| "The effect of the inflammatory mediator bradykinin on glycoprotein synthesis and mucin secretion in the human colonic adenocarcinoma cell line HT29-18N2 was examined." | 3.69 | Bradykinin modulates mucin secretion but not synthesis from an intestinal goblet cell line. ( Phillips, TE; Stanley, CM, 1994) |
| "We investigated the antitumor effects of a synthetic lipid A derivative, DT-5461a, in combination with indomethacin in three experimental tumor models (peritoneal carcinomatosis, liver tumor, and lung tumor models) of transplanted colon 26 carcinoma in mice." | 3.69 | Effect of combined administration of a synthetic low-toxicity lipid A derivative, DT-5461a, and indomethacin in various experimental tumor models of colon 26 carcinoma in mice. ( Akimoto, T; Jimbo, T; Tohgo, A, 1995) |
| "To explore an anti-tumor effect of indomethacin on human colon adenocarcinoma cell line HCT116, and its mechanism." | 3.69 | [Neoplasm-inhibiting effect and sensitivity-promoting effect of indomethacin in vitro]. ( Duan, C; Leng, A; Shi, J; Zhang, G, 1997) |
| "The antitumor activity of indomethacin (IND) was investigated in mice bearing advanced colon 26 adenocarcinoma compared with its early transplants." | 3.67 | Antitumor activity of indomethacin in mice bearing advanced colon 26 carcinoma compared with those with early transplants. ( Ishitsuka, H; Tanaka, T; Tanaka, Y, 1989) |
| " The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers." | 3.67 | [Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987) |
| "The histamine-2 receptor antagonist cimetidine (10(-5)M) and the prostaglandin synthesis inhibitor indomethacin (10(-8)M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma." | 3.67 | Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. ( Flodgren, P; Sjögren, HO, 1985) |
| "The anti-inflammatory drug indomethacin was tested for antitumor activity against transplantable mouse colon adenocarcinoma 38 (colon 38)." | 3.66 | Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin. ( Goto, A; Narisawa, T; Sano, M; Sato, M; Takahashi, T, 1983) |
| "We aimed to evaluate in colon cancer cells a combination of six agents directed to block the tumor anabolism (orlistat + lonidamine + DON) and the host catabolism (growth hormone + insulin + indomethacin)." | 1.62 | Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy. ( Chavez-Blanco, A; Diaz-Chavez, J; Dominguez-Gomez, G; Duenas-Gonzalez, A; Hua, S; Juarez, M; Lai, D; Perez-Montiel, D; Ponce-Toledo, RI; Schcolnik-Cabrera, A; Torres, N; Tovar, AR; Vargas-Castillo, A, 2021) |
| "This study evaluated the potential anticolon cancer effects of juglone (5-hydroxy-1,4-naphthoquinone) in combination with indomethacin." | 1.56 | Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. ( Devaraj, H; Seetha, A; Sudhandiran, G, 2020) |
| "The results revealed that exposure of colon cancer cells to resveratrol inhibited cell viability." | 1.43 | Resveratrol Treatment Inhibits Proliferation of and Induces Apoptosis in Human Colon Cancer Cells. ( Feng, M; Huang, ZH; Xiong, JP; Zhan, ZY; Zhong, LX, 2016) |
| "Indomethacin prodrugs were synthesized and characterized by FTIR and NMR, and dissolution test simulating gastrointestinal tract was employed to screen the colon-specific prodrug." | 1.36 | [Synthesis of colon-specific prodrug of indomethacin and its inhibitory effect on liver metastasis from colon cancer]. ( Cai, X; Chen, RF; Jiang, ZP; Li, LQ; Li, ZH; Peng, NF; Yang, LQ; Zhou, JJ; Zhou, QB, 2010) |
| "Indomethacin treatment significantly decreased WT survivin and survivin-DeltaEx3 (30." | 1.34 | Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells. ( Chiou, SK; Huang, R; Mandayam, S; Tarnawski, AS, 2007) |
| "PKCdelta is reported to be reduced in colon cancers." | 1.33 | Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. ( Eggo, MC; Langman, MJ; Lewis, AE; Susarla, R; Wong, BC, 2005) |
| "Human colon cancer Caco-2 cells were treated with either: placebo, IND (0." | 1.33 | Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells. ( Chai, J; Huang, RH; Tarnawski, AS, 2006) |
| "In the colon cancer cell line HT29 butyrate-mediated proliferation inhibition was enhanced by the additional presence of indomethacin (IM) and/or nordihydroguaiaretic acid (NDGA)." | 1.33 | Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid. ( Amberger, A; Csordas, A; Galfi, P; Margreiter, R; Neogrady, Z, 2005) |
| "Indomethacin can inhibit the growth of transplanted human colorectal HCT116 tumor in association with a significant reduction in angiogenesis, which may be achieved through inhibition of VEGF." | 1.32 | Experimental study of the inhibitory effect of indomethacin on the growth and angiogenesis of human colon cancer xenografts. ( Wang, HM; Zhang, GY, 2004) |
| "Lysine clonixinate (LC) is a nonsteroidal anti-inflammatory drug (NSAID) with good gastrointestinal tolerance." | 1.31 | [Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia]. ( De Los Santos, AR; Di Girolamo, G; Farina, M; Fernández de Gimeno, MA; Franchi, A; Martí, ML, 2001) |
| "Indomethacin impaired growth of human colon cancer cells (Caco-2 and HCT-116)." | 1.31 | Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells. ( Dauletbaev, N; Milovic, V; Stein, J; Turchanowa, L, 2001) |
| "Aspirin may suppress tumour incidence via salicylate by enhancing apoptosis in carcinogen-initiated cells." | 1.30 | Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis. ( Barnes, CJ; Cameron, IL; Hardman, WE; Lee, M, 1998) |
| "The present report demonstrates that colon cancer cells of human (HT-29) and mouse (MCA-38) origin markedly inhibit the generation of activated killer cells in murine spleen cell cultures." | 1.29 | Colon adenocarcinoma cells inhibit anti-CD3-activated killer cell induction. ( Blay, J; Hoskin, DW; Reynolds, T, 1994) |
| "Indomethacin was given orally to 40 of the rats." | 1.28 | Effect of indomethacin in autotransplanted colonic tumors. ( Duvander, A; Rubio, CA; Sveander, M; Wallin, B; Ware, J, 1989) |
| "When indomethacin (IND) was administered intrarectally twice a week for 19 consecutive weeks after completion of AOM injection, induced-colon tumors was significantly suppressed." | 1.28 | [Effects of indomethacin and prostaglandin E2 administered intrarectally on colon carcinogenesis induced by azoxymethane (AOM) in rats]. ( Fujimaki, M; Tazawa, K; Yamashita, I, 1989) |
| "Indomethacin treatment to rats bearing dimethylhydrazine-induced colonic cancer resulted in increased mortality (p less than 0." | 1.27 | Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats. ( Abate, S; Califano, G; Danzi, M; Ferulano, GP, 1984) |
| "Cimetidine is a histamine type 2 receptor antagonist and indomethacin is an inhibitor of prostaglandin synthesis." | 1.27 | Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat. ( Caignard, A; Martin, F; Martin, M; Reisser, D; Thomas, B, 1984) |
| "Indomethacin has no mitogenic activity." | 1.27 | Enhancement of T lymphocyte proliferative response to mitogens by indomethacin in breast and colorectal cancer patients. ( Bruno, S; Han, T; Ledesma, EJ; Nemoto, T, 1983) |
| "Indomethacin has been reported to suppress the growth of colonic tumors induced in rats by various carcinogenic drugs." | 1.27 | Effect of indomethacin on the growth of colon cancer cells in syngeneic rats. ( Caignard, A; Martin, F; Martin, MS; Olsson, NO, 1984) |
| "Four members of a Gardner's syndrome family had rectal and colon polyposis treated with nonsteroid anti-inflammatory drugs." | 1.27 | Sulindac for polyposis of the colon. ( Loughry, RW; Waddell, WR, 1983) |
| "The treatment with indomethacin substantially 1) inhibited the tumor growth, 2) prolonged the survival time, 3) caused a regression and disappearance of tumor with some cured mice and 4) reduced the levels of PGE2 and ornithine decarboxylase activity, a first rate limiting enzyme of polyamine synthesis in tumor tissue." | 1.27 | [Inhibition of the growth of a murine transplantable tumor, colon 26, by the prostaglandin synthetase inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Suzuki, K; Takahashi, M; Yoshioka, H, 1987) |
| " The most prominent toxic feature was hemorrhagic colitis which could be alleviated when rMuTNF was preceded by i." | 1.27 | Anti-tumor activity of recombinant mouse tumor necrosis factor (TNF) on colon cancer in rats is promoted by recombinant rat interferon gamma; toxicity is reduced by indomethacin. ( De Bruin, RW; Fiers, W; Ijzermans, JN; Jeekel, J; Marquet, RL, 1987) |
| " However, the 10-week cessation of treatment following this effective dosage led to a rapid development of tumors." | 1.26 | Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment. ( Goto, A; Kudo, T; Narisawa, T; Sato, M; Takahashi, T; Tani, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (26.61) | 18.7374 |
| 1990's | 26 (23.85) | 18.2507 |
| 2000's | 39 (35.78) | 29.6817 |
| 2010's | 11 (10.09) | 24.3611 |
| 2020's | 4 (3.67) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, W | 1 |
| Zhou, J | 1 |
| Zhang, T | 1 |
| Zhu, H | 1 |
| Qian, H | 1 |
| Zhang, H | 1 |
| Huang, W | 1 |
| Gust, R | 1 |
| Seetha, A | 2 |
| Devaraj, H | 2 |
| Sudhandiran, G | 2 |
| Schcolnik-Cabrera, A | 1 |
| Chavez-Blanco, A | 1 |
| Dominguez-Gomez, G | 1 |
| Juarez, M | 1 |
| Vargas-Castillo, A | 1 |
| Ponce-Toledo, RI | 1 |
| Lai, D | 1 |
| Hua, S | 1 |
| Tovar, AR | 1 |
| Torres, N | 1 |
| Perez-Montiel, D | 1 |
| Diaz-Chavez, J | 1 |
| Duenas-Gonzalez, A | 1 |
| Yang, C | 1 |
| Zhang, Y | 1 |
| Cai, P | 1 |
| Yuan, S | 1 |
| Ma, Q | 1 |
| Song, Y | 1 |
| Wei, H | 1 |
| Wu, Z | 2 |
| Qi, X | 1 |
| Ma, Y | 1 |
| Coombes, AG | 1 |
| Kon, R | 1 |
| Ikarashi, N | 1 |
| Nagoya, C | 1 |
| Takayama, T | 1 |
| Kusunoki, Y | 1 |
| Ishii, M | 1 |
| Ueda, H | 1 |
| Ochiai, W | 1 |
| Machida, Y | 1 |
| Sugita, K | 1 |
| Sugiyama, K | 1 |
| Feng, M | 1 |
| Zhong, LX | 1 |
| Zhan, ZY | 1 |
| Huang, ZH | 1 |
| Xiong, JP | 1 |
| Orido, T | 2 |
| Fujino, H | 4 |
| Hasegawa, Y | 1 |
| Toyomura, K | 1 |
| Kawashima, T | 2 |
| Murayama, T | 4 |
| Hossain, Z | 1 |
| Hosokawa, M | 1 |
| Takahashi, K | 1 |
| Foreman, JE | 1 |
| Sorg, JM | 1 |
| McGinnis, KS | 1 |
| Rigas, B | 3 |
| Williams, JL | 1 |
| Clapper, ML | 1 |
| Gonzalez, FJ | 1 |
| Peters, JM | 1 |
| Réti, A | 1 |
| Pap, E | 1 |
| Zalatnai, A | 1 |
| Jeney, A | 1 |
| Kralovánszky, J | 1 |
| Budai, B | 1 |
| Chiou, SK | 2 |
| Hoa, N | 1 |
| Peng, NF | 1 |
| Yang, LQ | 1 |
| Chen, RF | 1 |
| Cai, X | 1 |
| Li, LQ | 1 |
| Li, ZH | 1 |
| Zhou, QB | 1 |
| Zhou, JJ | 1 |
| Jiang, ZP | 1 |
| Chen, SZ | 1 |
| Qiu, ZG | 1 |
| Tai, HH | 1 |
| Chi, X | 1 |
| Tong, M | 1 |
| Brunelli, C | 1 |
| Amici, C | 1 |
| Angelini, M | 1 |
| Fracassi, C | 1 |
| Belardo, G | 1 |
| Santoro, MG | 1 |
| Ikawa, Y | 1 |
| Otake, S | 1 |
| Zhou, D | 1 |
| Papayannis, I | 1 |
| Mackenzie, GG | 1 |
| Alston, N | 1 |
| Ouyang, N | 1 |
| Huang, L | 1 |
| Nie, T | 1 |
| Wong, CC | 1 |
| Kim, TI | 1 |
| Jin, SH | 1 |
| Kang, EH | 1 |
| Shin, SK | 1 |
| Choi, KY | 1 |
| Kim, WH | 1 |
| Zhou, W | 2 |
| Jiang, ZW | 2 |
| Tian, J | 1 |
| Jiang, J | 2 |
| Li, N | 2 |
| Li, JS | 2 |
| Yasumaru, M | 1 |
| Tsuji, S | 2 |
| Tsujii, M | 1 |
| Irie, T | 1 |
| Komori, M | 1 |
| Kimura, A | 1 |
| Nishida, T | 1 |
| Kakiuchi, Y | 1 |
| Kawai, N | 1 |
| Murata, H | 1 |
| Horimoto, M | 1 |
| Sasaki, Y | 1 |
| Hayashi, N | 1 |
| Kawano, S | 2 |
| Hori, M | 1 |
| Wang, HM | 2 |
| Zhang, GY | 4 |
| Kovaríková, M | 1 |
| Hofmanová, J | 1 |
| Soucek, K | 1 |
| Kozubík, A | 1 |
| Pozzi, A | 1 |
| Yan, X | 1 |
| Macias-Perez, I | 1 |
| Wei, S | 1 |
| Hata, AN | 1 |
| Breyer, RM | 1 |
| Morrow, JD | 1 |
| Capdevila, JH | 1 |
| McCarthy, DO | 2 |
| Whitney, P | 1 |
| Hitt, A | 2 |
| Al-Majid, S | 1 |
| Lewis, AE | 1 |
| Susarla, R | 1 |
| Wong, BC | 2 |
| Langman, MJ | 1 |
| Eggo, MC | 1 |
| Graves, E | 1 |
| Kobayashi, S | 1 |
| Nantz, R | 1 |
| Kitamura, T | 1 |
| Higashikubo, R | 1 |
| Horikoshi, N | 1 |
| Xu, MH | 1 |
| Cheng, YL | 1 |
| Xiao, ZQ | 1 |
| Tang, FQ | 1 |
| Galfi, P | 1 |
| Neogrady, Z | 1 |
| Amberger, A | 1 |
| Margreiter, R | 1 |
| Csordas, A | 1 |
| Kapitanović, S | 2 |
| Cacev, T | 1 |
| Antica, M | 1 |
| Kralj, M | 2 |
| Cavrić, G | 1 |
| Pavelić, K | 2 |
| Spaventi, R | 1 |
| Yoshii, M | 1 |
| Jikuhara, A | 1 |
| Mori, S | 1 |
| Iwagaki, H | 1 |
| Takahashi, HK | 1 |
| Nishibori, M | 1 |
| Tanaka, N | 1 |
| He, H | 1 |
| Xia, HH | 1 |
| Wang, JD | 1 |
| Gu, Q | 1 |
| Lin, MC | 1 |
| Zou, B | 1 |
| Lam, SK | 1 |
| Chan, AO | 1 |
| Yuen, MF | 1 |
| Kung, HF | 1 |
| Jamaluddin, MS | 1 |
| Huang, RH | 1 |
| Chai, J | 1 |
| Tarnawski, AS | 2 |
| Mandayam, S | 1 |
| Huang, R | 1 |
| Chen, XB | 1 |
| Regan, JW | 1 |
| Soh, JW | 1 |
| Kazi, JU | 1 |
| Li, H | 1 |
| Thompson, WJ | 1 |
| Weinstein, IB | 1 |
| Balch, CM | 1 |
| Dougherty, PA | 1 |
| Cloud, GA | 1 |
| Tilden, AB | 1 |
| Caignard, A | 2 |
| Martin, M | 1 |
| Reisser, D | 1 |
| Thomas, B | 1 |
| Martin, F | 2 |
| Narisawa, T | 10 |
| Hermanek, P | 1 |
| Habs, M | 1 |
| Schmähl, D | 1 |
| Olsson, NO | 1 |
| Martin, MS | 1 |
| Han, T | 1 |
| Nemoto, T | 1 |
| Ledesma, EJ | 1 |
| Bruno, S | 1 |
| Satoh, M | 1 |
| Sano, M | 4 |
| Takahashi, T | 4 |
| Danzi, M | 1 |
| Ferulano, GP | 1 |
| Abate, S | 1 |
| Califano, G | 1 |
| Metzger, U | 1 |
| Meier, J | 1 |
| Uhlschmid, G | 1 |
| Weihe, H | 1 |
| Sato, M | 4 |
| Goto, A | 2 |
| Waddell, WR | 1 |
| Loughry, RW | 1 |
| Tani, M | 1 |
| Kudo, T | 1 |
| Pituch-Noworolska, A | 1 |
| Jimbo, T | 1 |
| Akimoto, T | 1 |
| Tohgo, A | 1 |
| Stanley, CM | 1 |
| Phillips, TE | 1 |
| Hussey, HJ | 1 |
| Tisdale, MJ | 1 |
| Morgan, GP | 1 |
| Williams, JG | 1 |
| Hoskin, DW | 1 |
| Reynolds, T | 1 |
| Blay, J | 1 |
| Kisara, S | 1 |
| Maekawa, I | 1 |
| Sasaki, K | 2 |
| Suzuki, N | 1 |
| Hayashi, A | 1 |
| Furusawa, S | 1 |
| Takayanagi, Y | 1 |
| Shiff, SJ | 1 |
| Koutsos, MI | 1 |
| Qiao, L | 1 |
| Sawaoka, H | 1 |
| Takei, Y | 1 |
| Kobayashi, I | 1 |
| Nagano, K | 1 |
| Fusamoto, H | 1 |
| Kamada, T | 1 |
| Iigo, M | 1 |
| Nakagawa, T | 1 |
| Ishikawa, C | 1 |
| Iwahori, Y | 1 |
| Asamoto, M | 1 |
| Yazawa, K | 1 |
| Araki, E | 1 |
| Tsuda, H | 1 |
| Barnes, CJ | 2 |
| Hardman, WE | 2 |
| Cameron, IL | 2 |
| Lee, M | 2 |
| McKenzie, C | 1 |
| Marchbank, T | 1 |
| Playford, RJ | 1 |
| Otto, W | 1 |
| Thim, L | 1 |
| Parsons, ME | 1 |
| Kalgutkar, AS | 1 |
| Crews, BC | 1 |
| Rowlinson, SW | 1 |
| Garner, C | 1 |
| Seibert, K | 1 |
| Marnett, LJ | 1 |
| Franchi, A | 2 |
| Di Girolamo, G | 2 |
| de los Santos, AR | 2 |
| Marti, ML | 2 |
| Gimeno, MA | 1 |
| Van Lieshout, EM | 1 |
| Tiemessen, DM | 1 |
| Roelofs, HM | 1 |
| Peters, WH | 1 |
| Erickson, BA | 1 |
| Longo, WE | 1 |
| Panesar, N | 1 |
| Mazuski, JE | 1 |
| Kaminski, DL | 1 |
| Djordjevic, B | 1 |
| Lange, CS | 1 |
| Schwartz, MS | 1 |
| Rotman, M | 1 |
| Ogino, M | 1 |
| Hisatomi, H | 1 |
| Hanazono, M | 1 |
| Zhang, G | 1 |
| Duan, C | 1 |
| Shi, J | 1 |
| Leng, A | 1 |
| Schwenger, P | 1 |
| Alpert, D | 1 |
| Skolnik, EY | 1 |
| Vilcek, J | 1 |
| Ota, S | 1 |
| Tanaka, Y | 2 |
| Bamba, H | 1 |
| Kato, A | 1 |
| Matsuzaki, F | 1 |
| Kinoshita, T | 1 |
| Takahashi, Y | 1 |
| Sakashita, T | 1 |
| Inoue, H | 1 |
| Tanabe, T | 1 |
| Yoshimoto, T | 1 |
| Cassano, G | 1 |
| Gasparre, G | 1 |
| Susca, F | 1 |
| Lippe, C | 1 |
| Guanti, G | 1 |
| MacGregor, DJ | 1 |
| Kim, YS | 1 |
| Sleisenger, MH | 1 |
| Johnson, LK | 1 |
| Gieseler, F | 1 |
| Huang, Y | 1 |
| Horvath, CM | 1 |
| Waxman, S | 1 |
| Kang, HJ | 1 |
| Song, MJ | 1 |
| Choung, SY | 1 |
| Kim, SJ | 1 |
| Le, MO | 1 |
| Chen, ZY | 1 |
| Istfan, NW | 1 |
| Kovacević, D | 1 |
| Lukac, J | 1 |
| Spaventi, S | 1 |
| Frenkian, M | 1 |
| Segond, N | 1 |
| Pidoux, E | 1 |
| Cohen, R | 1 |
| Jullienne, A | 1 |
| Hattori, K | 1 |
| Matsushita, R | 1 |
| Kimura, K | 1 |
| Abe, Y | 1 |
| Nakashima, E | 1 |
| Farina, M | 1 |
| Fernández de Gimeno, MA | 1 |
| Turchanowa, L | 1 |
| Dauletbaev, N | 1 |
| Milovic, V | 1 |
| Stein, J | 1 |
| Mannella, W | 1 |
| Brodsky, I | 1 |
| Sufian, S | 1 |
| Matsumoto, T | 1 |
| Liu, LM | 1 |
| Yu, EX | 1 |
| Tanaka, T | 2 |
| Kojima, T | 1 |
| Yoshimi, N | 1 |
| Sugie, S | 1 |
| Mori, H | 1 |
| Lewis, JE | 1 |
| Shiiki, S | 1 |
| Fuchimoto, S | 1 |
| Orita, K | 1 |
| Gaffen, JD | 1 |
| Chambers, EA | 1 |
| Bennett, A | 1 |
| Ishitsuka, H | 1 |
| Rubio, CA | 1 |
| Wallin, B | 1 |
| Ware, J | 1 |
| Sveander, M | 1 |
| Duvander, A | 1 |
| Yamashita, I | 1 |
| Tazawa, K | 1 |
| Fujimaki, M | 1 |
| Takahashi, M | 4 |
| Masuda, T | 2 |
| Nagasawa, O | 2 |
| Suzuki, K | 1 |
| Yoshioka, H | 1 |
| Koyama, H | 2 |
| Niwa, M | 3 |
| Fukaura, Y | 1 |
| Wakizaka, A | 1 |
| Marquet, RL | 1 |
| Ijzermans, JN | 1 |
| De Bruin, RW | 1 |
| Fiers, W | 1 |
| Jeekel, J | 1 |
| Heneghan, JB | 1 |
| Kurosu, Y | 1 |
| Arai, T | 1 |
| Morita, K | 1 |
| Koike, M | 1 |
| Nakazawa, S | 1 |
| Ozawa, T | 1 |
| Flodgren, P | 1 |
| Sjögren, HO | 1 |
| Hosaka, S | 1 |
| Ellison, NM | 1 |
| Servi, RJ | 1 |
| Ito, T | 1 |
| Tanida, N | 1 |
| Shimoyama, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomised Controlled Trial of the Effects of Fish Oil Emulsion in Total Parenteral Nutrition Upon Tumour Vascularity in Patients With Hepatic Colorectal Metastases[NCT00942292] | Phase 2 | 20 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Colonic Neoplasms
| Article | Year |
|---|---|
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, | 2011 |
108 other studies available for indomethacin and Colonic Neoplasms
| Article | Year |
|---|---|
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Breast Neoplasms; Cell L | 2012 |
Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Prot | 2020 |
Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogenesis; Cell Count; Cell Line, Tumor; Collagen; Colonic Ne | 2021 |
Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Colonic Ne | 2021 |
Highly specific colon-targeted transformable capsules containing indomethacin immediate-release pellets for colon cancers therapy.
Topics: Animals; Capsules; Colonic Neoplasms; Drug Delivery Systems; Drug Liberation; Galactans; Hypromellos | 2020 |
Designing colon-specific delivery systems for anticancer drug-loaded nanoparticles: an evaluation of alginate carriers.
Topics: Alginates; Antineoplastic Agents; Colon; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Gl | 2014 |
Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.
Topics: Animals; Anthracenes; Aquaporin 3; Cell Line; Colon; Colonic Neoplasms; Diarrhea; Dinoprostone; HT29 | 2014 |
Resveratrol Treatment Inhibits Proliferation of and Induces Apoptosis in Human Colon Cancer Cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase | 2016 |
Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Cell Line, Tumor; | 2008 |
Growth inhibition and induction of apoptosis of colon cancer cell lines by applying marine phospholipid.
Topics: Animals; Antioxidants; Apoptosis; Arachidonic Acid; Asterias; Butylated Hydroxytoluene; Butyrates; C | 2009 |
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Coloni | 2009 |
Co-inhibition of cyclooxygenase-2 and dihydropyrimidine dehydrogenase by non-steroidal anti-inflammatory drugs in tumor cells and xenografts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Colonic Neoplasms; Cyclooxygena | 2009 |
Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caco-2 Cells; Cell Cycle Proteins; Colonic Neopl | 2009 |
Decrease in uptake of arachidonic acid by indomethacin in LS174T human colon cancer cells; a novel cyclooxygenase-2-inhibition-independent effect.
Topics: Arachidonic Acid; Blotting, Western; CD36 Antigens; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygen | 2010 |
[Synthesis of colon-specific prodrug of indomethacin and its inhibitory effect on liver metastasis from colon cancer].
Topics: Amylose; Animals; Colon; Colonic Neoplasms; Delayed-Action Preparations; Drug Delivery Systems; HT29 | 2010 |
Combined treatment with GH, insulin, and indomethacin alleviates cancer cachexia in a mouse model.
Topics: Adenocarcinoma; Animals; Biomarkers; Body Weight; Cachexia; Colonic Neoplasms; Cytokines; Drug Combi | 2011 |
The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR, causing a translational block in human colorectal cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colonic Ne | 2012 |
Indomethacin antagonizes EP(2) prostanoid receptor activation in LS174T human colon cancer cells.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Colon | 2012 |
The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neop | 2013 |
The role of mitogen-activated protein kinases and their relationship with NF-kappaB and PPARgamma in indomethacin-Induced apoptosis of colon cancer cells.
Topics: Apoptosis; Colonic Neoplasms; Humans; Indomethacin; MAP Kinase Signaling System; Mitogen-Activated P | 2002 |
Role of NF-kappaB and cytokine in experimental cancer cachexia.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Composition; Cachexia; Coloni | 2003 |
Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; | 2003 |
Experimental study of the inhibitory effect of indomethacin on the growth and angiogenesis of human colon cancer xenografts.
Topics: Animals; Colonic Neoplasms; Cyclooxygenase 2; Humans; Indomethacin; Isoenzymes; Membrane Proteins; M | 2004 |
The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status.
Topics: Adenocarcinoma; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Butyrates; Caspase 3; Caspases; Cell | 2004 |
Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation.
Topics: Adenocarcinoma; Animals; Arachidonic Acid; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Cycli | 2004 |
Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Colonic Neo | 2004 |
[Role of NF-kappa B in cancer cachexia].
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cachexia; Colonic Neoplasms; Indom | 2004 |
Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205.
Topics: Acetamides; Acetophenones; Alkaloids; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apopto | 2005 |
Indomethacin preserves muscle mass and reduces levels of E3 ligases and TNF receptor type 1 in the gastrocnemius muscle of tumor-bearing mice.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, We | 2005 |
Indomethacin suppresses growth of colon cancer via inhibition of angiogenesis in vivo.
Topics: Angiogenesis Inhibitors; Animals; Cell Division; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; | 2005 |
Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation.
Topics: Carcinoma; Colonic Neoplasms; DNA Replication; Extracellular Signal-Regulated MAP Kinases; HeLa Cell | 2005 |
Effect of indomethacin on cell cycle proteins in colon cancer cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Cycle Proteins; Cell Line, Tumor; Colonic Neoplasms; C | 2005 |
Two-dimensional polyacrylamide gel electrophoresis analysis of indomethacin-treated human colon cancer cells.
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Electrophoresis, Gel, Two | 2005 |
Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrates; Cell Line, Tumor; Cell Proliferati | 2005 |
Effect of indomethacin on E-cadherin and beta-catenin expression in HT-29 colon cancer cells.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Tr | 2006 |
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxyg | 2005 |
Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Colonic Neoplas | 2006 |
Aspirin upregulates expression of urokinase type plasminogen activator receptor (uPAR) gene in human colon cancer cells through AP1.
Topics: Aspirin; Blotting, Western; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Cyclooxygenase 1; Hu | 2006 |
Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caco-2 Cells; Caspases; Colonic | 2006 |
Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Colonic Neoplasms; Gene Expression Regulation, | 2007 |
Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells.
Topics: Cell Line, Tumor; Colforsin; Colonic Neoplasms; Cyclic AMP; Dinoprostone; Down-Regulation; Gene Expr | 2007 |
Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.
Topics: Apoptosis; Celecoxib; Cell Adhesion Molecules; Cell Proliferation; Colonic Neoplasms; Cyclic GMP; Cy | 2008 |
Prostaglandin E2-mediated suppression of cellular immunity in colon cancer patients.
Topics: Adult; Aged; Colonic Neoplasms; Concanavalin A; Dinoprostone; Female; Humans; Immunity, Cellular; In | 1984 |
Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Colonic | 1984 |
Reduction of carcinogenicity of N-nitrosomethylurea by indomethacin and failure of resuming effect of prostaglandin E2 (PGE2) against indomethacin.
Topics: Animals; Colonic Neoplasms; Dinoprostone; Indomethacin; Male; Methylnitrosourea; Nitrosourea Compoun | 1984 |
Effect of indomethacin on the growth of colon cancer cells in syngeneic rats.
Topics: Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Colonic Neoplasms; Dinoprostone; | 1984 |
Enhancement of T lymphocyte proliferative response to mitogens by indomethacin in breast and colorectal cancer patients.
Topics: Adult; Aged; Breast Neoplasms; Colonic Neoplasms; Concanavalin A; Ethanol; Female; Humans; Indometha | 1983 |
Inhibition of initiation and promotion by N-methylnitrosourea-induced colon carcinogenesis in rats by non-steroid anti-inflammatory agent indomethacin.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Female; Indomethacin; Methylnitrosourea; Nitrosourea Com | 1983 |
Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats.
Topics: Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Female; Indomethacin; M | 1984 |
Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Drinking; Eating | 1984 |
Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Indomethacin; M | 1983 |
Sulindac for polyposis of the colon.
Topics: Adolescent; Adult; Colonic Neoplasms; Drug Evaluation; Female; Gardner Syndrome; Humans; Indenes; In | 1983 |
Inhibition of development of methylnitrosourea-induced rat colonic tumors by peroral administration of indomethacin.
Topics: Animals; Colonic Neoplasms; Female; Indomethacin; Methylnitrosourea; Neoplasms, Experimental; Rats; | 1982 |
Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Female; Indomethacin; Methylnitrosourea; Neoplasms, Expe | 1981 |
The response of cancer patients' lymphocytes to mitogen. The effect of indomethacin on adherent and non-adherent cells activity.
Topics: Adult; Aged; Breast Neoplasms; Cell Adhesion; Colonic Neoplasms; Concanavalin A; Humans; Indomethaci | 1981 |
Effect of combined administration of a synthetic low-toxicity lipid A derivative, DT-5461a, and indomethacin in various experimental tumor models of colon 26 carcinoma in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dinoprostone; Disacchari | 1995 |
Bradykinin modulates mucin secretion but not synthesis from an intestinal goblet cell line.
Topics: Adenocarcinoma; Bradykinin; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibo | 1994 |
Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Arachidonic Acid; Benzeneacetamides; Cell Division; C | 1994 |
Tumouricidal effect of indomethacin in the esophagus.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Esophageal Neoplasms; Humans; Indomethac | 1993 |
Colon adenocarcinoma cells inhibit anti-CD3-activated killer cell induction.
Topics: Adenocarcinoma; Animals; CD3 Complex; Colonic Neoplasms; Female; Humans; Immune Tolerance; Indometha | 1994 |
Antitumor activity of acemetacin in mice bearing colon 26 carcinoma: a preliminary report.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dinoprostone; Indomethacin; Male; Mice | 1993 |
Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; CDC2 Protein Kinase; CD | 1996 |
Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines.
Topics: Cell Division; Cell Line; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In | 1996 |
Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung.
Topics: Animals; Antineoplastic Agents; Aspirin; Colonic Neoplasms; Cyclooxygenase Inhibitors; Docosahexaeno | 1997 |
Aspirin, but not sodium salicylate, indomethacin, or nabumetone, reversibly suppresses 1,2-dimethylhydrazine-induced colonic aberrant crypt foci in rats.
Topics: 1,2-Dimethylhydrazine; 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroi | 1997 |
Pancreatic spasmolytic polypeptide protects the gastric mucosa but does not inhibit acid secretion or motility.
Topics: Animals; Cell Line; Colonic Neoplasms; Electric Stimulation; Gastric Acid; Gastric Mucosa; Gastroint | 1997 |
Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apopt | 1998 |
Aspirin-like molecules that covalently inactivate cyclooxygenase-2.
Topics: Acetylation; Acetylene; Alkynes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding | 1998 |
[Effect of lysine clonixinate and indomethacin on lipoxygenase and cyclooxygenase activity in colon isolated from cancer patients].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Colon; Colonic Neoplasms; Cycl | 1998 |
Nonsteroidal anti-inflammatory drugs enhance glutathione S-transferase theta levels in rat colon.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colon; Colonic Neoplasms; Diet | 1998 |
The effect of selective cyclooxygenase inhibitors on intestinal epithelial cell mitogenesis.
Topics: Animals; Apoptosis; Blood; Blotting, Western; Cell Division; Cell Line; Colonic Neoplasms; Cyclooxyg | 1999 |
Clonogenic inactivation of colon cancer-derived cells treated with 5-fluorouracil and indomethacin in hybrid spheroids.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Survival; Colonic Neoplasms; Cyclooxygenase In | 1998 |
Effectiveness of indomethacin as an antitumor agent in Colon 26-bearing conventional and nude mice, and telomerase activity in the tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colon; Colonic Neoplasms; Humans; Indomethacin; Live | 1999 |
[Neoplasm-inhibiting effect and sensitivity-promoting effect of indomethacin in vitro].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Division; Co | 1997 |
Cell-type-specific activation of c-Jun N-terminal kinase by salicylates.
Topics: Acetaminophen; Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium-Ca | 1999 |
Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Cholera Toxin; | 1999 |
Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells.
Topics: Cell Division; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; DNA, Complementary; ErbB Recep | 1999 |
Effect of prostaglandin E(2) on the proliferation, Ca(2+) mobilization and cAMP in HT-29 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Bombesin; Calcium; Cell Division; Colonic N | 2000 |
Chemoprevention of colon cancer carcinogenesis by balsalazide: inhibition of azoxymethane-induced aberrant crypt formation in the rat colon and intestinal tumor formation in the B6-Min/+ mouse.
Topics: Aminosalicylic Acids; Animals; Anti-Ulcer Agents; Anticarcinogenic Agents; Azoxymethane; Cell Divisi | 2000 |
The dilemma of gastroenterological oncology: we know a lot but we still achieve too little.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspases; Colonic Neoplasms; Cyclooxy | 2000 |
Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting | 2000 |
Transcriptional induction of Nur77 by indomethacin that results in apoptosis of colon cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; DNA-Bi | 2000 |
Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Butylated Hydroxytoluene; Cell Count; Colo | 2000 |
Effect of the nonsteroidal anti-inflammatory drug indomethacin on proliferation and apoptosis of colon carcinoma cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Caco-2 Ce | 2001 |
Indomethacin, a cox inhibitor, enhances 15-PGDH and decreases human tumoral C cells proliferation.
Topics: Blotting, Western; Cell Division; Colonic Neoplasms; Cyclooxygenase Inhibitors; Enzyme Activation; F | 2001 |
Synergistic effect of indomethacin with adriamycin and cisplatin on tumor growth.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antineoplastic; Antin | 2001 |
[Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Clonixin; Colon; Colonic Neopl | 2001 |
Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells.
Topics: Acetylation; Acetyltransferases; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cell Divisio | 2001 |
Postoperative fever in patients with hematologic malignancy.
Topics: Adult; Aged; Colonic Neoplasms; Female; Fever; Humans; Indomethacin; Leukemia; Male; Neoplasms, Mult | 1977 |
[Comprehensive "4-step analgesic ladder" therapy in treating cancer-related pain-analysis of 486 cases].
Topics: Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Drugs, Chinese Herbal; Female; Humans; Indomethac | 1992 |
Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats.
Topics: Adenocarcinoma; Animals; Anthraquinones; Carcinoma, Squamous Cell; Colonic Neoplasms; Enterocolitis; | 1991 |
Urticarial vasculitis occurring in association with visceral malignancy.
Topics: Adenocarcinoma; Aged; Antigen-Antibody Complex; Colon; Colonic Neoplasms; Female; Humans; Indomethac | 1990 |
A comparison of the antitumor effects of natural human tumor necrosis factors alpha and beta: the roles of arachidonic acid metabolism and intracellular cAMP.
Topics: Arachidonic Acid; Arachidonic Acids; Breast Neoplasms; Colforsin; Colonic Neoplasms; Cyclic AMP; Dex | 1990 |
The effects of dipyridamole and indomethacin on methotrexate cytotoxicity in LoVo human colon cancer cells.
Topics: Cell Division; Cell Survival; Colonic Neoplasms; Dipyridamole; Humans; Indomethacin; Methotrexate; T | 1989 |
Antitumor activity of indomethacin in mice bearing advanced colon 26 carcinoma compared with those with early transplants.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Dinoprostone; Indo | 1989 |
Effect of indomethacin in autotransplanted colonic tumors.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1989 |
[Effects of indomethacin and prostaglandin E2 administered intrarectally on colon carcinogenesis induced by azoxymethane (AOM) in rats].
Topics: Administration, Rectal; Animals; Azoxymethane; Colon; Colonic Neoplasms; Dinoprostone; Indomethacin; | 1989 |
[Inhibition of the growth of a murine transplantable tumor, colon 26, by the prostaglandin synthetase inhibitor, indomethacin].
Topics: Administration, Oral; Animals; Body Weight; Colonic Neoplasms; Cyclooxygenase Inhibitors; Dinoprosto | 1987 |
Involvement of prostaglandin E2 in bile acid-caused promotion of colon carcinogenesis and anti-promotion by the cyclooxygenase inhibitor indomethacin.
Topics: Administration, Oral; Administration, Rectal; Animals; Carcinogens; Colonic Neoplasms; Cyclooxygenas | 1987 |
Anti-tumor activity of recombinant mouse tumor necrosis factor (TNF) on colon cancer in rats is promoted by recombinant rat interferon gamma; toxicity is reduced by indomethacin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neop | 1987 |
Inhibition of human colon tumor growth in nude mice by indomethacin.
Topics: Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Humans; Indomethacin; Mice; Mice, Nude; N | 1985 |
Indomethacin enhancement of lymphocyte responses to phytohemagglutinin in breast, stomach and colorectal cancer patients.
Topics: Adjuvants, Immunologic; Adult; Aged; Breast Neoplasms; Colonic Neoplasms; Humans; Indomethacin; Lymp | 1988 |
[Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin].
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Dinoprostone; D | 1987 |
[Investigation of endogenous prostaglandins in 1,2-dimethyl-hydrazine induced colonic cancer in rats--inhibition of proliferation in colonic cancer with indomethacin treatment].
Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Indomethacin; Methylhydrazines; Pr | 1986 |
Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.
Topics: Antibody-Dependent Cell Cytotoxicity; Carcinoma; Cimetidine; Colonic Neoplasms; Cytotoxicity, Immuno | 1985 |
Prostaglandin E2 counteracts the inhibition by indomethacin of rat colon ornithine decarboxylase induction by deoxycholic acid.
Topics: Animals; Cocarcinogenesis; Colon; Colonic Neoplasms; Deoxycholic Acid; Dinoprostone; Enzyme Inductio | 1985 |
Acute renal failure and death following sequential intermediate-dose methotrexate and 5-FU: a possible adverse effect due to concomitant indomethacin administration.
Topics: Acute Kidney Injury; Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic N | 1985 |
Prevention of colon polyposis and carcinomas by right hemicolectomy and indomethacin in animal model.
Topics: Animals; Bile Acids and Salts; Colectomy; Colonic Neoplasms; Colonic Polyps; Feces; Female; Indometh | 1985 |