Page last updated: 2024-10-29

indomethacin and Colonic Neoplasms

indomethacin has been researched along with Colonic Neoplasms in 109 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Colonic Neoplasms: Tumors or cancer of the COLON.

Research Excerpts

ExcerptRelevanceReference
" This study implies the therapeutic effect of IND and juglone [JUG] against colon carcinogenesis, without gastric ulceration - an adverse side effect of IND."8.02Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis. ( Devaraj, H; Seetha, A; Sudhandiran, G, 2021)
" We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice."7.72Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004)
" The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers."7.67[Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987)
"The anti-inflammatory drug indomethacin was tested for antitumor activity against transplantable mouse colon adenocarcinoma 38 (colon 38)."7.66Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin. ( Goto, A; Narisawa, T; Sano, M; Sato, M; Takahashi, T, 1983)
" Flurbiprofen, indomethacin and other NSAIDs stimulated 15-PGDH activity in colon cancer HT29 cells as well as in lung cancer A549 cells and glioblastoma T98G cells."4.87Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). ( Chi, X; Tai, HH; Tong, M, 2011)
" This study implies the therapeutic effect of IND and juglone [JUG] against colon carcinogenesis, without gastric ulceration - an adverse side effect of IND."4.02Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis. ( Devaraj, H; Seetha, A; Sudhandiran, G, 2021)
" We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice."3.72Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004)
"To assess the putative involvement of NF-kappaB and pro-inflammatory cytokines in the pathogenesis of cancer cachexia and the therapeutic efficacy of indomethacin (IND) on cachexia."3.72Role of NF-kappaB and cytokine in experimental cancer cachexia. ( Jiang, J; Jiang, ZW; Li, JS; Li, N; Tian, J; Zhou, W, 2003)
" In our study, the effects of TNF-alpha, inhibitors of arachidonic acid (AA) metabolism (baicalein, BA; indomethacin, INDO; niflumic acid, NA; nordihydroguaiaretic acid, NDGA), and/or their combinations on undifferentiated or sodium butyrate (NaBt)-differentiated human colon adenocarcinoma HT-29 cells were compared."3.72The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status. ( Hofmanová, J; Kovaríková, M; Kozubík, A; Soucek, K, 2004)
"To assess the putative involvement of NF-kappaB and pro-inflammatory cytokines in the pathogenesis of cancer cachexia and the therapeutic efficacy of indomethacin (IND) on cachexia."3.72[Role of NF-kappa B in cancer cachexia]. ( Jiang, J; Jiang, ZW; Li, JS; Li, N; Zhou, W, 2004)
" In this paper, we present the effect of indomethacin on growth inhibition and alterations in the expression of several genes involved in cell cycle and apoptosis in CaCo-2 colon adenocarcinoma cells."3.71Effect of the nonsteroidal anti-inflammatory drug indomethacin on proliferation and apoptosis of colon carcinoma cells. ( Kapitanović, S; Kovacević, D; Kralj, M; Lukac, J; Pavelić, K; Spaventi, S, 2001)
"The clonogenic hybrid spheroid assay has been used to determine the toxicity of 5-fluorouracil (5-FU), alone or in combination with indomethacin, in LoVo cells (a human colon adenocarcinoma line)."3.70Clonogenic inactivation of colon cancer-derived cells treated with 5-fluorouracil and indomethacin in hybrid spheroids. ( Djordjevic, B; Lange, CS; Rotman, M; Schwartz, MS, 1998)
"The effect of the polyunsaturated fatty acids (PUFAs) linoleic acid (LA) and arachidonic acid (AA) on the growth of two murine colon adenocarcinoma cell lines (MAC26 and MAC13) has been determined both in vitro and in vivo."3.69Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo. ( Hussey, HJ; Tisdale, MJ, 1994)
" We evaluated the effect of aspirin (ASA) and three other structurally unrelated NSAIDs (indomethacin, naproxen, and piroxicam) on cell proliferation, cell cycle phase distribution, and the development of apoptosis in HT-29 colon adenocarcinoma cells in vitro."3.69Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. ( Koutsos, MI; Qiao, L; Rigas, B; Shiff, SJ, 1996)
"The effect of the inflammatory mediator bradykinin on glycoprotein synthesis and mucin secretion in the human colonic adenocarcinoma cell line HT29-18N2 was examined."3.69Bradykinin modulates mucin secretion but not synthesis from an intestinal goblet cell line. ( Phillips, TE; Stanley, CM, 1994)
"We investigated the antitumor effects of a synthetic lipid A derivative, DT-5461a, in combination with indomethacin in three experimental tumor models (peritoneal carcinomatosis, liver tumor, and lung tumor models) of transplanted colon 26 carcinoma in mice."3.69Effect of combined administration of a synthetic low-toxicity lipid A derivative, DT-5461a, and indomethacin in various experimental tumor models of colon 26 carcinoma in mice. ( Akimoto, T; Jimbo, T; Tohgo, A, 1995)
"To explore an anti-tumor effect of indomethacin on human colon adenocarcinoma cell line HCT116, and its mechanism."3.69[Neoplasm-inhibiting effect and sensitivity-promoting effect of indomethacin in vitro]. ( Duan, C; Leng, A; Shi, J; Zhang, G, 1997)
"The antitumor activity of indomethacin (IND) was investigated in mice bearing advanced colon 26 adenocarcinoma compared with its early transplants."3.67Antitumor activity of indomethacin in mice bearing advanced colon 26 carcinoma compared with those with early transplants. ( Ishitsuka, H; Tanaka, T; Tanaka, Y, 1989)
" The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers."3.67[Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987)
"The histamine-2 receptor antagonist cimetidine (10(-5)M) and the prostaglandin synthesis inhibitor indomethacin (10(-8)M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma."3.67Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. ( Flodgren, P; Sjögren, HO, 1985)
"The anti-inflammatory drug indomethacin was tested for antitumor activity against transplantable mouse colon adenocarcinoma 38 (colon 38)."3.66Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin. ( Goto, A; Narisawa, T; Sano, M; Sato, M; Takahashi, T, 1983)
"We aimed to evaluate in colon cancer cells a combination of six agents directed to block the tumor anabolism (orlistat + lonidamine + DON) and the host catabolism (growth hormone + insulin + indomethacin)."1.62Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy. ( Chavez-Blanco, A; Diaz-Chavez, J; Dominguez-Gomez, G; Duenas-Gonzalez, A; Hua, S; Juarez, M; Lai, D; Perez-Montiel, D; Ponce-Toledo, RI; Schcolnik-Cabrera, A; Torres, N; Tovar, AR; Vargas-Castillo, A, 2021)
"This study evaluated the potential anticolon cancer effects of juglone (5-hydroxy-1,4-naphthoquinone) in combination with indomethacin."1.56Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. ( Devaraj, H; Seetha, A; Sudhandiran, G, 2020)
"The results revealed that exposure of colon cancer cells to resveratrol inhibited cell viability."1.43Resveratrol Treatment Inhibits Proliferation of and Induces Apoptosis in Human Colon Cancer Cells. ( Feng, M; Huang, ZH; Xiong, JP; Zhan, ZY; Zhong, LX, 2016)
"Indomethacin prodrugs were synthesized and characterized by FTIR and NMR, and dissolution test simulating gastrointestinal tract was employed to screen the colon-specific prodrug."1.36[Synthesis of colon-specific prodrug of indomethacin and its inhibitory effect on liver metastasis from colon cancer]. ( Cai, X; Chen, RF; Jiang, ZP; Li, LQ; Li, ZH; Peng, NF; Yang, LQ; Zhou, JJ; Zhou, QB, 2010)
"Indomethacin treatment significantly decreased WT survivin and survivin-DeltaEx3 (30."1.34Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells. ( Chiou, SK; Huang, R; Mandayam, S; Tarnawski, AS, 2007)
"PKCdelta is reported to be reduced in colon cancers."1.33Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. ( Eggo, MC; Langman, MJ; Lewis, AE; Susarla, R; Wong, BC, 2005)
"Human colon cancer Caco-2 cells were treated with either: placebo, IND (0."1.33Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells. ( Chai, J; Huang, RH; Tarnawski, AS, 2006)
"In the colon cancer cell line HT29 butyrate-mediated proliferation inhibition was enhanced by the additional presence of indomethacin (IM) and/or nordihydroguaiaretic acid (NDGA)."1.33Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid. ( Amberger, A; Csordas, A; Galfi, P; Margreiter, R; Neogrady, Z, 2005)
"Indomethacin can inhibit the growth of transplanted human colorectal HCT116 tumor in association with a significant reduction in angiogenesis, which may be achieved through inhibition of VEGF."1.32Experimental study of the inhibitory effect of indomethacin on the growth and angiogenesis of human colon cancer xenografts. ( Wang, HM; Zhang, GY, 2004)
"Lysine clonixinate (LC) is a nonsteroidal anti-inflammatory drug (NSAID) with good gastrointestinal tolerance."1.31[Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia]. ( De Los Santos, AR; Di Girolamo, G; Farina, M; Fernández de Gimeno, MA; Franchi, A; Martí, ML, 2001)
"Indomethacin impaired growth of human colon cancer cells (Caco-2 and HCT-116)."1.31Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells. ( Dauletbaev, N; Milovic, V; Stein, J; Turchanowa, L, 2001)
"Aspirin may suppress tumour incidence via salicylate by enhancing apoptosis in carcinogen-initiated cells."1.30Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis. ( Barnes, CJ; Cameron, IL; Hardman, WE; Lee, M, 1998)
"The present report demonstrates that colon cancer cells of human (HT-29) and mouse (MCA-38) origin markedly inhibit the generation of activated killer cells in murine spleen cell cultures."1.29Colon adenocarcinoma cells inhibit anti-CD3-activated killer cell induction. ( Blay, J; Hoskin, DW; Reynolds, T, 1994)
"Indomethacin was given orally to 40 of the rats."1.28Effect of indomethacin in autotransplanted colonic tumors. ( Duvander, A; Rubio, CA; Sveander, M; Wallin, B; Ware, J, 1989)
"When indomethacin (IND) was administered intrarectally twice a week for 19 consecutive weeks after completion of AOM injection, induced-colon tumors was significantly suppressed."1.28[Effects of indomethacin and prostaglandin E2 administered intrarectally on colon carcinogenesis induced by azoxymethane (AOM) in rats]. ( Fujimaki, M; Tazawa, K; Yamashita, I, 1989)
"Indomethacin treatment to rats bearing dimethylhydrazine-induced colonic cancer resulted in increased mortality (p less than 0."1.27Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats. ( Abate, S; Califano, G; Danzi, M; Ferulano, GP, 1984)
"Cimetidine is a histamine type 2 receptor antagonist and indomethacin is an inhibitor of prostaglandin synthesis."1.27Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat. ( Caignard, A; Martin, F; Martin, M; Reisser, D; Thomas, B, 1984)
"Indomethacin has no mitogenic activity."1.27Enhancement of T lymphocyte proliferative response to mitogens by indomethacin in breast and colorectal cancer patients. ( Bruno, S; Han, T; Ledesma, EJ; Nemoto, T, 1983)
"Indomethacin has been reported to suppress the growth of colonic tumors induced in rats by various carcinogenic drugs."1.27Effect of indomethacin on the growth of colon cancer cells in syngeneic rats. ( Caignard, A; Martin, F; Martin, MS; Olsson, NO, 1984)
"Four members of a Gardner's syndrome family had rectal and colon polyposis treated with nonsteroid anti-inflammatory drugs."1.27Sulindac for polyposis of the colon. ( Loughry, RW; Waddell, WR, 1983)
"The treatment with indomethacin substantially 1) inhibited the tumor growth, 2) prolonged the survival time, 3) caused a regression and disappearance of tumor with some cured mice and 4) reduced the levels of PGE2 and ornithine decarboxylase activity, a first rate limiting enzyme of polyamine synthesis in tumor tissue."1.27[Inhibition of the growth of a murine transplantable tumor, colon 26, by the prostaglandin synthetase inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Suzuki, K; Takahashi, M; Yoshioka, H, 1987)
" The most prominent toxic feature was hemorrhagic colitis which could be alleviated when rMuTNF was preceded by i."1.27Anti-tumor activity of recombinant mouse tumor necrosis factor (TNF) on colon cancer in rats is promoted by recombinant rat interferon gamma; toxicity is reduced by indomethacin. ( De Bruin, RW; Fiers, W; Ijzermans, JN; Jeekel, J; Marquet, RL, 1987)
" However, the 10-week cessation of treatment following this effective dosage led to a rapid development of tumors."1.26Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment. ( Goto, A; Kudo, T; Narisawa, T; Sato, M; Takahashi, T; Tani, M, 1981)

Research

Studies (109)

TimeframeStudies, this research(%)All Research%
pre-199029 (26.61)18.7374
1990's26 (23.85)18.2507
2000's39 (35.78)29.6817
2010's11 (10.09)24.3611
2020's4 (3.67)2.80

Authors

AuthorsStudies
Liu, W1
Zhou, J1
Zhang, T1
Zhu, H1
Qian, H1
Zhang, H1
Huang, W1
Gust, R1
Seetha, A2
Devaraj, H2
Sudhandiran, G2
Schcolnik-Cabrera, A1
Chavez-Blanco, A1
Dominguez-Gomez, G1
Juarez, M1
Vargas-Castillo, A1
Ponce-Toledo, RI1
Lai, D1
Hua, S1
Tovar, AR1
Torres, N1
Perez-Montiel, D1
Diaz-Chavez, J1
Duenas-Gonzalez, A1
Yang, C1
Zhang, Y1
Cai, P1
Yuan, S1
Ma, Q1
Song, Y1
Wei, H1
Wu, Z2
Qi, X1
Ma, Y1
Coombes, AG1
Kon, R1
Ikarashi, N1
Nagoya, C1
Takayama, T1
Kusunoki, Y1
Ishii, M1
Ueda, H1
Ochiai, W1
Machida, Y1
Sugita, K1
Sugiyama, K1
Feng, M1
Zhong, LX1
Zhan, ZY1
Huang, ZH1
Xiong, JP1
Orido, T2
Fujino, H4
Hasegawa, Y1
Toyomura, K1
Kawashima, T2
Murayama, T4
Hossain, Z1
Hosokawa, M1
Takahashi, K1
Foreman, JE1
Sorg, JM1
McGinnis, KS1
Rigas, B3
Williams, JL1
Clapper, ML1
Gonzalez, FJ1
Peters, JM1
Réti, A1
Pap, E1
Zalatnai, A1
Jeney, A1
Kralovánszky, J1
Budai, B1
Chiou, SK2
Hoa, N1
Peng, NF1
Yang, LQ1
Chen, RF1
Cai, X1
Li, LQ1
Li, ZH1
Zhou, QB1
Zhou, JJ1
Jiang, ZP1
Chen, SZ1
Qiu, ZG1
Tai, HH1
Chi, X1
Tong, M1
Brunelli, C1
Amici, C1
Angelini, M1
Fracassi, C1
Belardo, G1
Santoro, MG1
Ikawa, Y1
Otake, S1
Zhou, D1
Papayannis, I1
Mackenzie, GG1
Alston, N1
Ouyang, N1
Huang, L1
Nie, T1
Wong, CC1
Kim, TI1
Jin, SH1
Kang, EH1
Shin, SK1
Choi, KY1
Kim, WH1
Zhou, W2
Jiang, ZW2
Tian, J1
Jiang, J2
Li, N2
Li, JS2
Yasumaru, M1
Tsuji, S2
Tsujii, M1
Irie, T1
Komori, M1
Kimura, A1
Nishida, T1
Kakiuchi, Y1
Kawai, N1
Murata, H1
Horimoto, M1
Sasaki, Y1
Hayashi, N1
Kawano, S2
Hori, M1
Wang, HM2
Zhang, GY4
Kovaríková, M1
Hofmanová, J1
Soucek, K1
Kozubík, A1
Pozzi, A1
Yan, X1
Macias-Perez, I1
Wei, S1
Hata, AN1
Breyer, RM1
Morrow, JD1
Capdevila, JH1
McCarthy, DO2
Whitney, P1
Hitt, A2
Al-Majid, S1
Lewis, AE1
Susarla, R1
Wong, BC2
Langman, MJ1
Eggo, MC1
Graves, E1
Kobayashi, S1
Nantz, R1
Kitamura, T1
Higashikubo, R1
Horikoshi, N1
Xu, MH1
Cheng, YL1
Xiao, ZQ1
Tang, FQ1
Galfi, P1
Neogrady, Z1
Amberger, A1
Margreiter, R1
Csordas, A1
Kapitanović, S2
Cacev, T1
Antica, M1
Kralj, M2
Cavrić, G1
Pavelić, K2
Spaventi, R1
Yoshii, M1
Jikuhara, A1
Mori, S1
Iwagaki, H1
Takahashi, HK1
Nishibori, M1
Tanaka, N1
He, H1
Xia, HH1
Wang, JD1
Gu, Q1
Lin, MC1
Zou, B1
Lam, SK1
Chan, AO1
Yuen, MF1
Kung, HF1
Jamaluddin, MS1
Huang, RH1
Chai, J1
Tarnawski, AS2
Mandayam, S1
Huang, R1
Chen, XB1
Regan, JW1
Soh, JW1
Kazi, JU1
Li, H1
Thompson, WJ1
Weinstein, IB1
Balch, CM1
Dougherty, PA1
Cloud, GA1
Tilden, AB1
Caignard, A2
Martin, M1
Reisser, D1
Thomas, B1
Martin, F2
Narisawa, T10
Hermanek, P1
Habs, M1
Schmähl, D1
Olsson, NO1
Martin, MS1
Han, T1
Nemoto, T1
Ledesma, EJ1
Bruno, S1
Satoh, M1
Sano, M4
Takahashi, T4
Danzi, M1
Ferulano, GP1
Abate, S1
Califano, G1
Metzger, U1
Meier, J1
Uhlschmid, G1
Weihe, H1
Sato, M4
Goto, A2
Waddell, WR1
Loughry, RW1
Tani, M1
Kudo, T1
Pituch-Noworolska, A1
Jimbo, T1
Akimoto, T1
Tohgo, A1
Stanley, CM1
Phillips, TE1
Hussey, HJ1
Tisdale, MJ1
Morgan, GP1
Williams, JG1
Hoskin, DW1
Reynolds, T1
Blay, J1
Kisara, S1
Maekawa, I1
Sasaki, K2
Suzuki, N1
Hayashi, A1
Furusawa, S1
Takayanagi, Y1
Shiff, SJ1
Koutsos, MI1
Qiao, L1
Sawaoka, H1
Takei, Y1
Kobayashi, I1
Nagano, K1
Fusamoto, H1
Kamada, T1
Iigo, M1
Nakagawa, T1
Ishikawa, C1
Iwahori, Y1
Asamoto, M1
Yazawa, K1
Araki, E1
Tsuda, H1
Barnes, CJ2
Hardman, WE2
Cameron, IL2
Lee, M2
McKenzie, C1
Marchbank, T1
Playford, RJ1
Otto, W1
Thim, L1
Parsons, ME1
Kalgutkar, AS1
Crews, BC1
Rowlinson, SW1
Garner, C1
Seibert, K1
Marnett, LJ1
Franchi, A2
Di Girolamo, G2
de los Santos, AR2
Marti, ML2
Gimeno, MA1
Van Lieshout, EM1
Tiemessen, DM1
Roelofs, HM1
Peters, WH1
Erickson, BA1
Longo, WE1
Panesar, N1
Mazuski, JE1
Kaminski, DL1
Djordjevic, B1
Lange, CS1
Schwartz, MS1
Rotman, M1
Ogino, M1
Hisatomi, H1
Hanazono, M1
Zhang, G1
Duan, C1
Shi, J1
Leng, A1
Schwenger, P1
Alpert, D1
Skolnik, EY1
Vilcek, J1
Ota, S1
Tanaka, Y2
Bamba, H1
Kato, A1
Matsuzaki, F1
Kinoshita, T1
Takahashi, Y1
Sakashita, T1
Inoue, H1
Tanabe, T1
Yoshimoto, T1
Cassano, G1
Gasparre, G1
Susca, F1
Lippe, C1
Guanti, G1
MacGregor, DJ1
Kim, YS1
Sleisenger, MH1
Johnson, LK1
Gieseler, F1
Huang, Y1
Horvath, CM1
Waxman, S1
Kang, HJ1
Song, MJ1
Choung, SY1
Kim, SJ1
Le, MO1
Chen, ZY1
Istfan, NW1
Kovacević, D1
Lukac, J1
Spaventi, S1
Frenkian, M1
Segond, N1
Pidoux, E1
Cohen, R1
Jullienne, A1
Hattori, K1
Matsushita, R1
Kimura, K1
Abe, Y1
Nakashima, E1
Farina, M1
Fernández de Gimeno, MA1
Turchanowa, L1
Dauletbaev, N1
Milovic, V1
Stein, J1
Mannella, W1
Brodsky, I1
Sufian, S1
Matsumoto, T1
Liu, LM1
Yu, EX1
Tanaka, T2
Kojima, T1
Yoshimi, N1
Sugie, S1
Mori, H1
Lewis, JE1
Shiiki, S1
Fuchimoto, S1
Orita, K1
Gaffen, JD1
Chambers, EA1
Bennett, A1
Ishitsuka, H1
Rubio, CA1
Wallin, B1
Ware, J1
Sveander, M1
Duvander, A1
Yamashita, I1
Tazawa, K1
Fujimaki, M1
Takahashi, M4
Masuda, T2
Nagasawa, O2
Suzuki, K1
Yoshioka, H1
Koyama, H2
Niwa, M3
Fukaura, Y1
Wakizaka, A1
Marquet, RL1
Ijzermans, JN1
De Bruin, RW1
Fiers, W1
Jeekel, J1
Heneghan, JB1
Kurosu, Y1
Arai, T1
Morita, K1
Koike, M1
Nakazawa, S1
Ozawa, T1
Flodgren, P1
Sjögren, HO1
Hosaka, S1
Ellison, NM1
Servi, RJ1
Ito, T1
Tanida, N1
Shimoyama, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomised Controlled Trial of the Effects of Fish Oil Emulsion in Total Parenteral Nutrition Upon Tumour Vascularity in Patients With Hepatic Colorectal Metastases[NCT00942292]Phase 220 participants (Actual)Interventional2007-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for indomethacin and Colonic Neoplasms

ArticleYear
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
    Prostaglandins & other lipid mediators, 2011, Volume: 96, Issue:1-4

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line,

2011

Other Studies

108 other studies available for indomethacin and Colonic Neoplasms

ArticleYear
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
    Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Breast Neoplasms; Cell L

2012
Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells.
    Journal of biochemical and molecular toxicology, 2020, Volume: 34, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Prot

2020
Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis.
    Life sciences, 2021, Jan-01, Volume: 264

    Topics: Animals; Apoptosis; Azoxymethane; Carcinogenesis; Cell Count; Cell Line, Tumor; Collagen; Colonic Ne

2021
Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy.
    Scientific reports, 2021, 03-04, Volume: 11, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Colonic Ne

2021
Highly specific colon-targeted transformable capsules containing indomethacin immediate-release pellets for colon cancers therapy.
    Journal of drug targeting, 2020, Volume: 28, Issue:1

    Topics: Animals; Capsules; Colonic Neoplasms; Drug Delivery Systems; Drug Liberation; Galactans; Hypromellos

2020
Designing colon-specific delivery systems for anticancer drug-loaded nanoparticles: an evaluation of alginate carriers.
    Journal of biomedical materials research. Part A, 2014, Volume: 102, Issue:9

    Topics: Alginates; Antineoplastic Agents; Colon; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Gl

2014
Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.
    Journal of ethnopharmacology, 2014, Feb-27, Volume: 152, Issue:1

    Topics: Animals; Anthracenes; Aquaporin 3; Cell Line; Colon; Colonic Neoplasms; Diarrhea; Dinoprostone; HT29

2014
Resveratrol Treatment Inhibits Proliferation of and Induces Apoptosis in Human Colon Cancer Cells.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Apr-04, Volume: 22

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase

2016
Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells.
    Journal of pharmacological sciences, 2008, Volume: 108, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Cell Line, Tumor;

2008
Growth inhibition and induction of apoptosis of colon cancer cell lines by applying marine phospholipid.
    Nutrition and cancer, 2009, Volume: 61, Issue:1

    Topics: Animals; Antioxidants; Apoptosis; Arachidonic Acid; Asterias; Butylated Hydroxytoluene; Butyrates; C

2009
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
    Molecular carcinogenesis, 2009, Volume: 48, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Coloni

2009
Co-inhibition of cyclooxygenase-2 and dihydropyrimidine dehydrogenase by non-steroidal anti-inflammatory drugs in tumor cells and xenografts.
    Anticancer research, 2009, Volume: 29, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Colonic Neoplasms; Cyclooxygena

2009
Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths.
    Apoptosis : an international journal on programmed cell death, 2009, Volume: 14, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caco-2 Cells; Cell Cycle Proteins; Colonic Neopl

2009
Decrease in uptake of arachidonic acid by indomethacin in LS174T human colon cancer cells; a novel cyclooxygenase-2-inhibition-independent effect.
    Archives of biochemistry and biophysics, 2010, Feb-01, Volume: 494, Issue:1

    Topics: Arachidonic Acid; Blotting, Western; CD36 Antigens; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygen

2010
[Synthesis of colon-specific prodrug of indomethacin and its inhibitory effect on liver metastasis from colon cancer].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2010, Volume: 32, Issue:3

    Topics: Amylose; Animals; Colon; Colonic Neoplasms; Delayed-Action Preparations; Drug Delivery Systems; HT29

2010
Combined treatment with GH, insulin, and indomethacin alleviates cancer cachexia in a mouse model.
    The Journal of endocrinology, 2011, Volume: 208, Issue:2

    Topics: Adenocarcinoma; Animals; Biomarkers; Body Weight; Cachexia; Colonic Neoplasms; Cytokines; Drug Combi

2011
The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR, causing a translational block in human colorectal cancer cells.
    The Biochemical journal, 2012, Apr-15, Volume: 443, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colonic Ne

2012
Indomethacin antagonizes EP(2) prostanoid receptor activation in LS174T human colon cancer cells.
    European journal of pharmacology, 2012, Apr-05, Volume: 680, Issue:1-3

    Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Colon

2012
The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies.
    Carcinogenesis, 2013, Volume: 34, Issue:4

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neop

2013
The role of mitogen-activated protein kinases and their relationship with NF-kappaB and PPARgamma in indomethacin-Induced apoptosis of colon cancer cells.
    Annals of the New York Academy of Sciences, 2002, Volume: 973

    Topics: Apoptosis; Colonic Neoplasms; Humans; Indomethacin; MAP Kinase Signaling System; Mitogen-Activated P

2002
Role of NF-kappaB and cytokine in experimental cancer cachexia.
    World journal of gastroenterology, 2003, Volume: 9, Issue:7

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Composition; Cachexia; Coloni

2003
Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway.
    Cancer research, 2003, Oct-15, Volume: 63, Issue:20

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals;

2003
Experimental study of the inhibitory effect of indomethacin on the growth and angiogenesis of human colon cancer xenografts.
    Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2004, Volume: 24, Issue:2

    Topics: Animals; Colonic Neoplasms; Cyclooxygenase 2; Humans; Indomethacin; Isoenzymes; Membrane Proteins; M

2004
The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status.
    Differentiation; research in biological diversity, 2004, Volume: 72, Issue:1

    Topics: Adenocarcinoma; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Butyrates; Caspase 3; Caspases; Cell

2004
Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation.
    The Journal of biological chemistry, 2004, Jul-09, Volume: 279, Issue:28

    Topics: Adenocarcinoma; Animals; Arachidonic Acid; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Cycli

2004
Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma.
    Research in nursing & health, 2004, Volume: 27, Issue:3

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Colonic Neo

2004
[Role of NF-kappa B in cancer cachexia].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 2004, Jun-07, Volume: 42, Issue:11

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cachexia; Colonic Neoplasms; Indom

2004
Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205.
    Cellular signalling, 2005, Volume: 17, Issue:2

    Topics: Acetamides; Acetophenones; Alkaloids; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apopto

2005
Indomethacin preserves muscle mass and reduces levels of E3 ligases and TNF receptor type 1 in the gastrocnemius muscle of tumor-bearing mice.
    Research in nursing & health, 2005, Volume: 28, Issue:1

    Topics: Adenocarcinoma; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, We

2005
Indomethacin suppresses growth of colon cancer via inhibition of angiogenesis in vivo.
    World journal of gastroenterology, 2005, Jan-21, Volume: 11, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Cell Division; Cell Line, Tumor; Cell Survival; Colonic Neoplasms;

2005
Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation.
    Oncogene, 2005, Apr-21, Volume: 24, Issue:18

    Topics: Carcinoma; Colonic Neoplasms; DNA Replication; Extracellular Signal-Regulated MAP Kinases; HeLa Cell

2005
Effect of indomethacin on cell cycle proteins in colon cancer cell lines.
    World journal of gastroenterology, 2005, Mar-21, Volume: 11, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Cycle Proteins; Cell Line, Tumor; Colonic Neoplasms; C

2005
Two-dimensional polyacrylamide gel electrophoresis analysis of indomethacin-treated human colon cancer cells.
    World journal of gastroenterology, 2005, Apr-28, Volume: 11, Issue:16

    Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Electrophoresis, Gel, Two

2005
Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid.
    Cancer detection and prevention, 2005, Volume: 29, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrates; Cell Line, Tumor; Cell Proliferati

2005
Effect of indomethacin on E-cadherin and beta-catenin expression in HT-29 colon cancer cells.
    Experimental and molecular pathology, 2006, Volume: 80, Issue:1

    Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Tr

2006
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
    Journal of pharmacological sciences, 2005, Volume: 98, Issue:4

    Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxyg

2005
Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma.
    Cancer, 2006, Mar-15, Volume: 106, Issue:6

    Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Colonic Neoplas

2006
Aspirin upregulates expression of urokinase type plasminogen activator receptor (uPAR) gene in human colon cancer cells through AP1.
    Biochemical and biophysical research communications, 2006, Sep-22, Volume: 348, Issue:2

    Topics: Aspirin; Blotting, Western; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Cyclooxygenase 1; Hu

2006
Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells.
    World journal of gastroenterology, 2006, Oct-28, Volume: 12, Issue:40

    Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caco-2 Cells; Caspases; Colonic

2006
Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells.
    Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Colonic Neoplasms; Gene Expression Regulation,

2007
Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells.
    Biochemical and biophysical research communications, 2007, Aug-03, Volume: 359, Issue:3

    Topics: Cell Line, Tumor; Colforsin; Colonic Neoplasms; Cyclic AMP; Dinoprostone; Down-Regulation; Gene Expr

2007
Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.
    Molecular carcinogenesis, 2008, Volume: 47, Issue:7

    Topics: Apoptosis; Celecoxib; Cell Adhesion Molecules; Cell Proliferation; Colonic Neoplasms; Cyclic GMP; Cy

2008
Prostaglandin E2-mediated suppression of cellular immunity in colon cancer patients.
    Surgery, 1984, Volume: 95, Issue:1

    Topics: Adult; Aged; Colonic Neoplasms; Concanavalin A; Dinoprostone; Female; Humans; Immunity, Cellular; In

1984
Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat.
    British journal of cancer, 1984, Volume: 50, Issue:5

    Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Colonic

1984
Reduction of carcinogenicity of N-nitrosomethylurea by indomethacin and failure of resuming effect of prostaglandin E2 (PGE2) against indomethacin.
    Journal of cancer research and clinical oncology, 1984, Volume: 108, Issue:2

    Topics: Animals; Colonic Neoplasms; Dinoprostone; Indomethacin; Male; Methylnitrosourea; Nitrosourea Compoun

1984
Effect of indomethacin on the growth of colon cancer cells in syngeneic rats.
    International journal of immunopharmacology, 1984, Volume: 6, Issue:4

    Topics: Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Colonic Neoplasms; Dinoprostone;

1984
Enhancement of T lymphocyte proliferative response to mitogens by indomethacin in breast and colorectal cancer patients.
    International journal of immunopharmacology, 1983, Volume: 5, Issue:1

    Topics: Adult; Aged; Breast Neoplasms; Colonic Neoplasms; Concanavalin A; Ethanol; Female; Humans; Indometha

1983
Inhibition of initiation and promotion by N-methylnitrosourea-induced colon carcinogenesis in rats by non-steroid anti-inflammatory agent indomethacin.
    Carcinogenesis, 1983, Volume: 4, Issue:10

    Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Female; Indomethacin; Methylnitrosourea; Nitrosourea Com

1983
Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats.
    Carcinogenesis, 1984, Volume: 5, Issue:2

    Topics: Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Female; Indomethacin; M

1984
Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer.
    Diseases of the colon and rectum, 1984, Volume: 27, Issue:6

    Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Drinking; Eating

1984
Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin.
    Journal of cancer research and clinical oncology, 1983, Volume: 106, Issue:1

    Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Indomethacin; M

1983
Sulindac for polyposis of the colon.
    Journal of surgical oncology, 1983, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Colonic Neoplasms; Drug Evaluation; Female; Gardner Syndrome; Humans; Indenes; In

1983
Inhibition of development of methylnitrosourea-induced rat colonic tumors by peroral administration of indomethacin.
    Gan, 1982, Volume: 73, Issue:3

    Topics: Animals; Colonic Neoplasms; Female; Indomethacin; Methylnitrosourea; Neoplasms, Experimental; Rats;

1982
Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment.
    Cancer research, 1981, Volume: 41, Issue:5

    Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Female; Indomethacin; Methylnitrosourea; Neoplasms, Expe

1981
The response of cancer patients' lymphocytes to mitogen. The effect of indomethacin on adherent and non-adherent cells activity.
    Archivum immunologiae et therapiae experimentalis, 1981, Volume: 29, Issue:2

    Topics: Adult; Aged; Breast Neoplasms; Cell Adhesion; Colonic Neoplasms; Concanavalin A; Humans; Indomethaci

1981
Effect of combined administration of a synthetic low-toxicity lipid A derivative, DT-5461a, and indomethacin in various experimental tumor models of colon 26 carcinoma in mice.
    Cancer immunology, immunotherapy : CII, 1995, Volume: 40, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dinoprostone; Disacchari

1995
Bradykinin modulates mucin secretion but not synthesis from an intestinal goblet cell line.
    Agents and actions, 1994, Volume: 42, Issue:3-4

    Topics: Adenocarcinoma; Bradykinin; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibo

1994
Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo.
    British journal of cancer, 1994, Volume: 70, Issue:1

    Topics: Adenocarcinoma; Analysis of Variance; Animals; Arachidonic Acid; Benzeneacetamides; Cell Division; C

1994
Tumouricidal effect of indomethacin in the esophagus.
    Postgraduate medical journal, 1993, Volume: 69, Issue:818

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Esophageal Neoplasms; Humans; Indomethac

1993
Colon adenocarcinoma cells inhibit anti-CD3-activated killer cell induction.
    Cancer immunology, immunotherapy : CII, 1994, Volume: 38, Issue:3

    Topics: Adenocarcinoma; Animals; CD3 Complex; Colonic Neoplasms; Female; Humans; Immune Tolerance; Indometha

1994
Antitumor activity of acemetacin in mice bearing colon 26 carcinoma: a preliminary report.
    Research communications in chemical pathology and pharmacology, 1993, Volume: 81, Issue:2

    Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dinoprostone; Indomethacin; Male; Mice

1993
Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis.
    Experimental cell research, 1996, Jan-10, Volume: 222, Issue:1

    Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; CDC2 Protein Kinase; CD

1996
Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines.
    Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 55, Issue:3

    Topics: Cell Division; Cell Line; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In

1996
Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung.
    British journal of cancer, 1997, Volume: 75, Issue:5

    Topics: Animals; Antineoplastic Agents; Aspirin; Colonic Neoplasms; Cyclooxygenase Inhibitors; Docosahexaeno

1997
Aspirin, but not sodium salicylate, indomethacin, or nabumetone, reversibly suppresses 1,2-dimethylhydrazine-induced colonic aberrant crypt foci in rats.
    Digestive diseases and sciences, 1997, Volume: 42, Issue:5

    Topics: 1,2-Dimethylhydrazine; 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroi

1997
Pancreatic spasmolytic polypeptide protects the gastric mucosa but does not inhibit acid secretion or motility.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 1

    Topics: Animals; Cell Line; Colonic Neoplasms; Electric Stimulation; Gastric Acid; Gastric Mucosa; Gastroint

1997
Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis.
    British journal of cancer, 1998, Volume: 77, Issue:4

    Topics: 1,2-Dimethylhydrazine; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apopt

1998
Aspirin-like molecules that covalently inactivate cyclooxygenase-2.
    Science (New York, N.Y.), 1998, May-22, Volume: 280, Issue:5367

    Topics: Acetylation; Acetylene; Alkynes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding

1998
[Effect of lysine clonixinate and indomethacin on lipoxygenase and cyclooxygenase activity in colon isolated from cancer patients].
    Medicina, 1998, Volume: 58, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Colon; Colonic Neoplasms; Cycl

1998
Nonsteroidal anti-inflammatory drugs enhance glutathione S-transferase theta levels in rat colon.
    Biochimica et biophysica acta, 1998, Aug-24, Volume: 1381, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colon; Colonic Neoplasms; Diet

1998
The effect of selective cyclooxygenase inhibitors on intestinal epithelial cell mitogenesis.
    The Journal of surgical research, 1999, Volume: 81, Issue:1

    Topics: Animals; Apoptosis; Blood; Blotting, Western; Cell Division; Cell Line; Colonic Neoplasms; Cyclooxyg

1999
Clonogenic inactivation of colon cancer-derived cells treated with 5-fluorouracil and indomethacin in hybrid spheroids.
    Acta oncologica (Stockholm, Sweden), 1998, Volume: 37, Issue:7-8

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Survival; Colonic Neoplasms; Cyclooxygenase In

1998
Effectiveness of indomethacin as an antitumor agent in Colon 26-bearing conventional and nude mice, and telomerase activity in the tumors.
    Experimental animals, 1999, Volume: 48, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colon; Colonic Neoplasms; Humans; Indomethacin; Live

1999
[Neoplasm-inhibiting effect and sensitivity-promoting effect of indomethacin in vitro].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1997, Volume: 22, Issue:6

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Division; Co

1997
Cell-type-specific activation of c-Jun N-terminal kinase by salicylates.
    Journal of cellular physiology, 1999, Volume: 179, Issue:1

    Topics: Acetaminophen; Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium-Ca

1999
Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression.
    European journal of pharmacology, 1999, Feb-12, Volume: 367, Issue:1

    Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Cholera Toxin;

1999
Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells.
    Biochimica et biophysica acta, 1999, Apr-19, Volume: 1438, Issue:1

    Topics: Cell Division; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; DNA, Complementary; ErbB Recep

1999
Effect of prostaglandin E(2) on the proliferation, Ca(2+) mobilization and cAMP in HT-29 human colon adenocarcinoma cells.
    Cancer letters, 2000, May-01, Volume: 152, Issue:2

    Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Bombesin; Calcium; Cell Division; Colonic N

2000
Chemoprevention of colon cancer carcinogenesis by balsalazide: inhibition of azoxymethane-induced aberrant crypt formation in the rat colon and intestinal tumor formation in the B6-Min/+ mouse.
    International journal of oncology, 2000, Volume: 17, Issue:1

    Topics: Aminosalicylic Acids; Animals; Anti-Ulcer Agents; Anticarcinogenic Agents; Azoxymethane; Cell Divisi

2000
The dilemma of gastroenterological oncology: we know a lot but we still achieve too little.
    International journal of colorectal disease, 2000, Volume: 15, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspases; Colonic Neoplasms; Cyclooxy

2000
Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate.
    Cancer research, 2000, Jun-15, Volume: 60, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting

2000
Transcriptional induction of Nur77 by indomethacin that results in apoptosis of colon cancer cells.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; DNA-Bi

2000
Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 2000, Volume: 63, Issue:5

    Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Butylated Hydroxytoluene; Cell Count; Colo

2000
Effect of the nonsteroidal anti-inflammatory drug indomethacin on proliferation and apoptosis of colon carcinoma cells.
    Journal of cancer research and clinical oncology, 2001, Volume: 127, Issue:3

    Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Caco-2 Ce

2001
Indomethacin, a cox inhibitor, enhances 15-PGDH and decreases human tumoral C cells proliferation.
    Prostaglandins & other lipid mediators, 2001, Volume: 65, Issue:1

    Topics: Blotting, Western; Cell Division; Colonic Neoplasms; Cyclooxygenase Inhibitors; Enzyme Activation; F

2001
Synergistic effect of indomethacin with adriamycin and cisplatin on tumor growth.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:10

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antineoplastic; Antin

2001
[Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia].
    Medicina, 2001, Volume: 61, Issue:5 Pt 1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Clonixin; Colon; Colonic Neopl

2001
Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells.
    European journal of clinical investigation, 2001, Volume: 31, Issue:10

    Topics: Acetylation; Acetyltransferases; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cell Divisio

2001
Postoperative fever in patients with hematologic malignancy.
    International surgery, 1977, Volume: 62, Issue:4

    Topics: Adult; Aged; Colonic Neoplasms; Female; Fever; Humans; Indomethacin; Leukemia; Male; Neoplasms, Mult

1977
[Comprehensive "4-step analgesic ladder" therapy in treating cancer-related pain-analysis of 486 cases].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1992, Volume: 12, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Drugs, Chinese Herbal; Female; Humans; Indomethac

1992
Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats.
    Carcinogenesis, 1991, Volume: 12, Issue:10

    Topics: Adenocarcinoma; Animals; Anthraquinones; Carcinoma, Squamous Cell; Colonic Neoplasms; Enterocolitis;

1991
Urticarial vasculitis occurring in association with visceral malignancy.
    Acta dermato-venereologica, 1990, Volume: 70, Issue:4

    Topics: Adenocarcinoma; Aged; Antigen-Antibody Complex; Colon; Colonic Neoplasms; Female; Humans; Indomethac

1990
A comparison of the antitumor effects of natural human tumor necrosis factors alpha and beta: the roles of arachidonic acid metabolism and intracellular cAMP.
    Japanese journal of clinical oncology, 1990, Volume: 20, Issue:3

    Topics: Arachidonic Acid; Arachidonic Acids; Breast Neoplasms; Colforsin; Colonic Neoplasms; Cyclic AMP; Dex

1990
The effects of dipyridamole and indomethacin on methotrexate cytotoxicity in LoVo human colon cancer cells.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:5

    Topics: Cell Division; Cell Survival; Colonic Neoplasms; Dipyridamole; Humans; Indomethacin; Methotrexate; T

1989
Antitumor activity of indomethacin in mice bearing advanced colon 26 carcinoma compared with those with early transplants.
    Cancer research, 1989, Nov-01, Volume: 49, Issue:21

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Dinoprostone; Indo

1989
Effect of indomethacin in autotransplanted colonic tumors.
    Diseases of the colon and rectum, 1989, Volume: 32, Issue:6

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines;

1989
[Effects of indomethacin and prostaglandin E2 administered intrarectally on colon carcinogenesis induced by azoxymethane (AOM) in rats].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1989, Volume: 86, Issue:7

    Topics: Administration, Rectal; Animals; Azoxymethane; Colon; Colonic Neoplasms; Dinoprostone; Indomethacin;

1989
[Inhibition of the growth of a murine transplantable tumor, colon 26, by the prostaglandin synthetase inhibitor, indomethacin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

    Topics: Administration, Oral; Animals; Body Weight; Colonic Neoplasms; Cyclooxygenase Inhibitors; Dinoprosto

1987
Involvement of prostaglandin E2 in bile acid-caused promotion of colon carcinogenesis and anti-promotion by the cyclooxygenase inhibitor indomethacin.
    Japanese journal of cancer research : Gann, 1987, Volume: 78, Issue:8

    Topics: Administration, Oral; Administration, Rectal; Animals; Carcinogens; Colonic Neoplasms; Cyclooxygenas

1987
Anti-tumor activity of recombinant mouse tumor necrosis factor (TNF) on colon cancer in rats is promoted by recombinant rat interferon gamma; toxicity is reduced by indomethacin.
    International journal of cancer, 1987, Oct-15, Volume: 40, Issue:4

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neop

1987
Inhibition of human colon tumor growth in nude mice by indomethacin.
    Progress in clinical and biological research, 1985, Volume: 181

    Topics: Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Humans; Indomethacin; Mice; Mice, Nude; N

1985
Indomethacin enhancement of lymphocyte responses to phytohemagglutinin in breast, stomach and colorectal cancer patients.
    The Japanese journal of surgery, 1988, Volume: 18, Issue:2

    Topics: Adjuvants, Immunologic; Adult; Aged; Breast Neoplasms; Colonic Neoplasms; Humans; Indomethacin; Lymp

1988
[Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:8

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Dinoprostone; D

1987
[Investigation of endogenous prostaglandins in 1,2-dimethyl-hydrazine induced colonic cancer in rats--inhibition of proliferation in colonic cancer with indomethacin treatment].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1986, Volume: 83, Issue:6

    Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Indomethacin; Methylhydrazines; Pr

1986
Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.
    Cancer immunology, immunotherapy : CII, 1985, Volume: 19, Issue:1

    Topics: Antibody-Dependent Cell Cytotoxicity; Carcinoma; Cimetidine; Colonic Neoplasms; Cytotoxicity, Immuno

1985
Prostaglandin E2 counteracts the inhibition by indomethacin of rat colon ornithine decarboxylase induction by deoxycholic acid.
    Japanese journal of cancer research : Gann, 1985, Volume: 76, Issue:5

    Topics: Animals; Cocarcinogenesis; Colon; Colonic Neoplasms; Deoxycholic Acid; Dinoprostone; Enzyme Inductio

1985
Acute renal failure and death following sequential intermediate-dose methotrexate and 5-FU: a possible adverse effect due to concomitant indomethacin administration.
    Cancer treatment reports, 1985, Volume: 69, Issue:3

    Topics: Acute Kidney Injury; Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic N

1985
Prevention of colon polyposis and carcinomas by right hemicolectomy and indomethacin in animal model.
    Cancer, 1985, Oct-01, Volume: 56, Issue:7

    Topics: Animals; Bile Acids and Salts; Colectomy; Colonic Neoplasms; Colonic Polyps; Feces; Female; Indometh

1985