indomethacin has been researched along with Colonic Inertia in 7 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Colonic Inertia: Symptom characterized by the passage of stool once a week or less.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 5.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| "Oral papaverine has been shown to be capable of antagonizing the constipation induced by a single dose of oral morphine." | 3.74 | Counteracting effect of papaverine on morphine inhibition of gastrointestinal transit in mice. ( Palmery, M; Piccolotti, P; Pimpinella, G; Romanelli, L; Tucci, P; Valeri, P, 2008) |
| "The traditional Chinese medicine Shundao Granules po markedly inhibited the formation of gastric ulcers induced by indomethacin, restraint and pyloric ligatin in rats." | 3.70 | [Pharmacological studies of shundao granules on gastrointestinal track]. ( Gu, W; Huang, C; Li, S; Yao, Y, 1998) |
| "0 mg/kg) and DMPG (10-40 micrograms/kg) overcame morphine-induced constipation in a dose-related manner, the respective ED50s being 0." | 3.67 | M&B 28,767: a potent anti-secretory and anti-ulcer PG analogue. A comparative study with 16, 16' dimethyl PGE2 methylester. ( Banerjee, AK; Christmas, AJ; Crowshaw, K; Heazell, MA; Ivers-Read, GC; Saunders, LC; Wyatt, D, 1984) |
| "Upper gastrointestinal haemorrhage and pseudomembranous colitis are potentially fatal manifestations of drug therapy." | 2.36 | Drug-induced gastrointestinal disease. ( Bramble, MG; Record, CO, 1978) |
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 1.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, W | 1 |
| Li, S | 1 |
| Yao, Y | 1 |
| Huang, C | 1 |
| Tucci, P | 1 |
| Palmery, M | 1 |
| Piccolotti, P | 1 |
| Pimpinella, G | 1 |
| Valeri, P | 1 |
| Romanelli, L | 1 |
| Banerjee, AK | 3 |
| Christmas, AJ | 3 |
| Crowshaw, K | 2 |
| Heazell, MA | 2 |
| Ivers-Read, GC | 1 |
| Saunders, LC | 1 |
| Wyatt, D | 1 |
| Keshavarzian, A | 1 |
| Isaacs, P | 1 |
| McColl, I | 1 |
| Sladen, GE | 1 |
| Hall, CE | 1 |
| Bramble, MG | 1 |
| Record, CO | 1 |
| Broughton, BJ | 1 |
| Burton, TS | 1 |
| Caton, MP | 1 |
| Coffee, EC | 1 |
| Stuttle, KA | 1 |
| Watkins, GL | 1 |
1 review available for indomethacin and Colonic Inertia
| Article | Year |
|---|---|
Drug-induced gastrointestinal disease.
Topics: Adrenal Cortex Hormones; Cathartics; Colon; Constipation; Diarrhea; Enterocolitis, Pseudomembranous; | 1978 |
6 other studies available for indomethacin and Colonic Inertia
| Article | Year |
|---|---|
[Pharmacological studies of shundao granules on gastrointestinal track].
Topics: Analgesics; Animals; Anti-Ulcer Agents; Constipation; Drugs, Chinese Herbal; Female; Gastric Acid; G | 1998 |
Counteracting effect of papaverine on morphine inhibition of gastrointestinal transit in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Constipation; Dexam | 2008 |
M&B 28,767: a potent anti-secretory and anti-ulcer PG analogue. A comparative study with 16, 16' dimethyl PGE2 methylester.
Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Constipation; Diarrhea; Gastric Acid; Gastroin | 1984 |
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin.
Topics: Adult; Body Weight; Constipation; Humans; Ileostomy; Indomethacin; Intestinal Obstruction; Intestina | 1983 |
A comparative study of the effects of prostaglandins and H2-receptor antagonists on gastric acid secretion, mucosal blood flow and ulcer formation.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Constipation; Dogs; Female; Gastric Mucosa; Gastrointestina | 1979 |
Synthesis and gastrointestinal pharmacology of some 15- and 16- modified (+/-)-11-deoxyprostaglandins.
Topics: Animals; Chemical Phenomena; Chemistry; Constipation; Digestive System; Drug Evaluation, Preclinical | 1978 |