indomethacin has been researched along with Colitis, Ulcerative in 40 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ulcerative colitis (UC) and Crohn's disease (CD) are two major forms of inflammatory bowel disease (IBD)." | 1.91 | Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats. ( Gruneck, L; Phunikhom, K; Popluechai, S; Sattayasai, J; Sharpton, TJ; Thipart, K, 2023) |
| "Naringin is a promising anti-inflammatory drug against various disorders including ulcerative colitis." | 1.56 | Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits. ( Borg, TM; El Naggar, EE; El-Sheakh, AR; Hamed, MF; Mohamed, EA, 2020) |
| "Development of ulcerative colitis was accompanied by the activation of iNOS/COX-2/5-LOX and increased contents of nitric oxide (NO), prostaglandin E₂ (PGE₂), and leukotriene B₄ (LTB₄)." | 1.37 | Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis. ( Fomenko, IS; Panasyuk, NB; Sklyarov, AY, 2011) |
| "Nicotine has been shown to reduce both tone and muscular activity in the human colon by releasing nitric oxide (NO) from nerves." | 1.35 | Nicotine-induced neurogenic relaxation in the mouse colon: changes with dextran sodium sulfate-induced colitis. ( Fujino, H; Hamada, Y; Horie, S; Murakami, I; Murayama, T; Yamane, S, 2009) |
| "First, patients with quiescent Crohn's disease and ulcerative colitis received the non-NSAID analgesic acetaminophen (n = 26) and the conventional NSAIDs naproxen (n = 32), diclofenac (n = 29), and indomethacin (n = 22) for 4 weeks." | 1.33 | Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. ( Bjarnason, I; Bjornsson, E; Maiden, L; Premchand, P; Sherwood, R; Smale, S; Takeuchi, K; Thjodleifsson, B, 2006) |
| "We tried to produce a new ulcerative colitis model in rats by topical administration of sulfhydryl blockers." | 1.30 | New ulcerative colitis model induced by sulfhydryl blockers in rats and the effects of antiinflammatory drugs on the colitis. ( Sato, F; Satoh, H; Szabo, S; Takami, K, 1997) |
| "Crohn's disease (CD) and ulcerative colitis (UC) represent clinically distinct chronic inflammatory bowel diseases (IBD) of unknown etiology." | 1.29 | Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis. ( Gurbindo, C; Justinich, C; Marchand, R; Menezes, J; Sabbah, S; Seidman, EG, 1993) |
| "Finally, supernatants from Crohn's disease and ulcerative colitis cell cultures failed to suppress interleukin-2 production by control CD4+ T cells." | 1.28 | Loss of interleukin-2-producing intestinal CD4+ T cells in inflammatory bowel disease. ( Fiocchi, C; Kusugami, K; Matsuura, T; Rachmilewitz, D; West, GA; Youngman, KR, 1991) |
| " Our data suggest that both the route of drug administration and dosing regimen employed affect the antiinflammatory potency and/or efficacy of compounds on colitis induced by acetic acid in the rat." | 1.28 | Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. ( Bostwick, JS; Decktor, DL; Fitzpatrick, LR; Pendleton, RG; Renzetti, M, 1990) |
| "A 67-year-old man with ulcerative colitis of 1 year's duration was hospitalized with myopericarditis." | 1.28 | [Cardiac involvement in inflammatory bowel disease]. ( Birnbaum, Y; Shpirer, Z, 1989) |
| "Miniaturised methods have been used to construct dose-response curves for the effects of inhibitory drugs on prostaglandin synthesis using individual rectal biopsies obtained from patients with ulcerative colitis." | 1.27 | Inhibition of prostaglandin synthetase in human rectal mucosa. ( Hawkey, CJ; Lo Casto, M, 1983) |
| "One patient had ulcerative colitis, while two patients had Crohn's disease." | 1.27 | Pleuropericarditis: an extraintestinal complication of inflammatory bowel disease. Report of three cases and review of literature. ( Brewster, AC; Darrah, JJ; Heilpern, RJ; Patwardhan, RV, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (50.00) | 18.7374 |
| 1990's | 7 (17.50) | 18.2507 |
| 2000's | 7 (17.50) | 29.6817 |
| 2010's | 3 (7.50) | 24.3611 |
| 2020's | 3 (7.50) | 2.80 |
| Authors | Studies |
|---|---|
| Thipart, K | 2 |
| Gruneck, L | 2 |
| Phunikhom, K | 2 |
| Sharpton, TJ | 2 |
| Sattayasai, J | 2 |
| Popluechai, S | 2 |
| Shanmugam, S | 1 |
| Thangaraj, P | 1 |
| Dos Santos Lima, B | 1 |
| Trindade, GGG | 1 |
| Narain, N | 1 |
| Mara de Oliveira E Silva, A | 1 |
| Santin, JR | 1 |
| Broering, MF | 1 |
| Serafini, MR | 1 |
| Quintans-Júnior, LJ | 1 |
| Antunes de Souza Araújo, A | 1 |
| El Naggar, EE | 1 |
| Mohamed, EA | 1 |
| Borg, TM | 1 |
| El-Sheakh, AR | 1 |
| Hamed, MF | 1 |
| Zídek, Z | 1 |
| Kverka, M | 1 |
| Dusilová, A | 1 |
| Kmoníčková, E | 1 |
| Jansa, P | 1 |
| Murakami, I | 1 |
| Hamada, Y | 1 |
| Yamane, S | 1 |
| Fujino, H | 1 |
| Horie, S | 1 |
| Murayama, T | 1 |
| Takamura, T | 1 |
| Harama, D | 1 |
| Matsuoka, S | 1 |
| Shimokawa, N | 1 |
| Nakamura, Y | 1 |
| Okumura, K | 1 |
| Ogawa, H | 1 |
| Kitamura, M | 1 |
| Nakao, A | 1 |
| Sklyarov, AY | 1 |
| Panasyuk, NB | 1 |
| Fomenko, IS | 1 |
| Jeffers, M | 1 |
| McDonald, WF | 1 |
| Chillakuru, RA | 1 |
| Yang, M | 1 |
| Nakase, H | 1 |
| Deegler, LL | 1 |
| Sylander, ED | 1 |
| Rittman, B | 1 |
| Bendele, A | 1 |
| Sartor, RB | 1 |
| Lichenstein, HS | 1 |
| Houchen, CW | 1 |
| Takeuchi, K | 2 |
| Smale, S | 1 |
| Premchand, P | 1 |
| Maiden, L | 1 |
| Sherwood, R | 1 |
| Thjodleifsson, B | 1 |
| Bjornsson, E | 1 |
| Bjarnason, I | 1 |
| Okayama, M | 1 |
| Hayashi, S | 1 |
| Aoi, Y | 1 |
| Nishio, H | 1 |
| Kato, S | 1 |
| Burcher, E | 1 |
| Shang, F | 1 |
| Warner, FJ | 1 |
| Du, Q | 1 |
| Lubowski, DZ | 1 |
| King, DW | 1 |
| Liu, L | 1 |
| Gould, SR | 1 |
| Brash, AR | 1 |
| Conolly, ME | 1 |
| Lennard-Jones, JE | 1 |
| Rhodes, JM | 1 |
| Bartholomew, TC | 1 |
| Jewell, DP | 1 |
| Rampton, DS | 2 |
| Sladen, GE | 1 |
| Holdstock, G | 2 |
| Chastenay, BF | 1 |
| Krawitt, EL | 2 |
| Hillier, K | 1 |
| Mason, PJ | 1 |
| Pacheco, S | 1 |
| Smith, CL | 1 |
| Ershler, WB | 1 |
| Hawkey, CJ | 3 |
| Lo Casto, M | 1 |
| Boughton-Smith, NK | 2 |
| Whittle, BJ | 2 |
| Patwardhan, RV | 1 |
| Heilpern, RJ | 1 |
| Brewster, AC | 1 |
| Darrah, JJ | 1 |
| Campieri, M | 1 |
| Lanfranchi, GA | 1 |
| Bazzocchi, G | 1 |
| Brignola, C | 1 |
| Benatti, A | 1 |
| Boccia, S | 1 |
| Labo', G | 1 |
| Gurbindo, C | 1 |
| Sabbah, S | 1 |
| Menezes, J | 1 |
| Justinich, C | 1 |
| Marchand, R | 1 |
| Seidman, EG | 1 |
| Wardle, TD | 1 |
| Hall, L | 1 |
| Turnberg, LA | 1 |
| Kimura, I | 1 |
| Nagahama, S | 1 |
| Kawasaki, M | 1 |
| Kataoka, M | 1 |
| Sato, M | 1 |
| Satoh, H | 1 |
| Sato, F | 1 |
| Takami, K | 1 |
| Szabo, S | 1 |
| McCartney, SA | 1 |
| Mitchell, JA | 1 |
| Fairclough, PD | 1 |
| Farthing, MJ | 1 |
| Warner, TD | 1 |
| Suenaert, P | 1 |
| Bulteel, V | 1 |
| Den Hond, E | 1 |
| Hiele, M | 1 |
| Peeters, M | 1 |
| Monsuur, F | 1 |
| Ghoos, Y | 1 |
| Rutgeerts, P | 1 |
| Smith, PR | 1 |
| Dawson, DJ | 1 |
| Swan, CH | 1 |
| Gilat, T | 1 |
| Ratan, J | 1 |
| Rosen, P | 1 |
| Peled, Y | 1 |
| Kusugami, K | 1 |
| Matsuura, T | 1 |
| West, GA | 1 |
| Youngman, KR | 2 |
| Rachmilewitz, D | 1 |
| Fiocchi, C | 2 |
| Fitzpatrick, LR | 1 |
| Bostwick, JS | 1 |
| Renzetti, M | 1 |
| Pendleton, RG | 1 |
| Decktor, DL | 1 |
| Birnbaum, Y | 1 |
| Shpirer, Z | 1 |
| Lauritsen, K | 1 |
| Laursen, LS | 1 |
| Bukhave, K | 1 |
| Rask-Madsen, J | 1 |
| Rigas, B | 1 |
| Tubbs, RR | 1 |
| Hart, FD | 1 |
| Perkins, ES | 1 |
| MacFaul, PA | 1 |
1 review available for indomethacin and Colitis, Ulcerative
| Article | Year |
|---|---|
Prostaglandins and ulcerative colitis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Colitis, Ulcerative; Cyclooxygenase Inhibitors; Dogs; | 1984 |
2 trials available for indomethacin and Colitis, Ulcerative
| Article | Year |
|---|---|
Prostaglandins and ulcerative colitis.
Topics: Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Method; Humans; Indomethacin; Prostaglan | 1979 |
Indomethacin in the treatment of uveitis. A double-blind trial.
Topics: Adolescent; Arthritis, Reactive; Clinical Trials as Topic; Colitis, Ulcerative; Diabetes Complicatio | 1965 |
37 other studies available for indomethacin and Colitis, Ulcerative
| Article | Year |
|---|---|
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
Topics: Acetic Acid; Animals; Anthocyanins; Bacteria; Colitis, Ulcerative; Crohn Disease; Gastrointestinal M | 2023 |
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
Topics: Acetic Acid; Animals; Anthocyanins; Bacteria; Colitis, Ulcerative; Crohn Disease; Gastrointestinal M | 2023 |
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
Topics: Acetic Acid; Animals; Anthocyanins; Bacteria; Colitis, Ulcerative; Crohn Disease; Gastrointestinal M | 2023 |
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
Topics: Acetic Acid; Animals; Anthocyanins; Bacteria; Colitis, Ulcerative; Crohn Disease; Gastrointestinal M | 2023 |
Protective effects of flavonoid composition rich P. subpeltata Ortega. on indomethacin induced experimental ulcerative colitis in rat models of inflammatory bowel diseases.
Topics: Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Disease Models, Animal; Flavonoids; G | 2020 |
Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Cytoprotection; Diseas | 2020 |
Dual inhibition of nitric oxide and prostaglandin E2 production by polysubstituted 2-aminopyrimidines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis, Ulcerative; Colon; Cyclooxygenas | 2016 |
Nicotine-induced neurogenic relaxation in the mouse colon: changes with dextran sodium sulfate-induced colitis.
Topics: Animals; Atropine; Bethanechol; Colitis, Ulcerative; Colon; Colon, Descending; Colon, Transverse; De | 2009 |
Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Cytochrome P-450 CYP1A1; Dextran Sulfate; Dinoprostone | 2010 |
Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis.
Topics: Acetic Acid; Animals; Antioxidants; Arachidonate 5-Lipoxygenase; Arginine; Benzoquinones; Celecoxib; | 2011 |
A novel human fibroblast growth factor treats experimental intestinal inflammation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Ce | 2002 |
FGF-20: FGFs--they keep growing and growing and growing!
Topics: Animals; Colitis, Ulcerative; Crohn Disease; Dinoprostone; Disease Models, Animal; Epithelial Cells; | 2003 |
Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colitis, Ul | 2006 |
Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats.
Topics: Animals; Cardiovascular Diseases; Celecoxib; Colitis, Ulcerative; Colon; Cyclooxygenase 1; Cyclooxyg | 2007 |
Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis.
Topics: Adult; Aged; Aged, 80 and over; Colitis, Ulcerative; Colon; Diverticulum, Colon; Female; Humans; In | 2008 |
Studies of prostaglandins and sulphasalazine in ulcerative colitis.
Topics: Adolescent; Adult; Aged; Carboprost; Child; Child, Preschool; Colitis, Ulcerative; Feces; Female; Hu | 1981 |
Inhibition of leucocyte motility by drugs used in ulcerative colitis.
Topics: Aminosalicylic Acids; Cell Movement; Chemotaxis, Leukocyte; Colitis, Ulcerative; Dose-Response Relat | 1981 |
Relapse of ulcerative proctocolitis during treatment with non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Colitis, Ulcerative; Female; Flurbiprofen; Humans; Ibuprofen; Indom | 1981 |
Increased suppressor cell activity in inflammatory bowel disease.
Topics: Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Humans; Hydrocortisone; In Vitro Technique | 1981 |
Ulcerative colitis: effect of sulphasalazine, its metabolites and indomethacin on the ability of human colonic mucosa to metabolize prostaglandins in vitro.
Topics: Alprostadil; Aminosalicylic Acids; Colitis, Ulcerative; Colon; Humans; In Vitro Techniques; Indometh | 1982 |
Defective lymphocyte IgA production in inflammatory bowel disease.
Topics: Adolescent; Adult; Antibody-Producing Cells; Child; Colitis, Ulcerative; Crohn Disease; Female; Huma | 1982 |
Inhibition of prostaglandin synthetase in human rectal mucosa.
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Colitis, Ulcerative; Cyclooxygenase Inhibitors; Dose | 1983 |
Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonate Lipoxygenases; Arachidoni | 1983 |
Pleuropericarditis: an extraintestinal complication of inflammatory bowel disease. Report of three cases and review of literature.
Topics: Adult; Aspirin; Colitis, Ulcerative; Crohn Disease; Humans; Indomethacin; Male; Middle Aged; Pericar | 1983 |
Prostaglandins, indomethacin, and ulcerative colitis.
Topics: Colitis, Ulcerative; Enema; Humans; Indomethacin; Prostaglandin Antagonists | 1980 |
Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis.
Topics: Adolescent; Cell Division; Child; Colitis, Ulcerative; Colon; Crohn Disease; Flow Cytometry; Humans; | 1993 |
Inter-relationships between inflammatory mediators released from colonic mucosa in ulcerative colitis and their effects on colonic secretion.
Topics: Adult; Animals; Colitis, Ulcerative; Colon; Culture Media; Culture Techniques; Dinoprostone; Eicosan | 1993 |
[Study on the experimental ulcerative colitis (UC) model induced by dextran sulfate sodium (DSS) in rats (3)].
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Dextran | 1996 |
New ulcerative colitis model induced by sulfhydryl blockers in rats and the effects of antiinflammatory drugs on the colitis.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Colitis, | 1997 |
Selective COX-2 inhibitors and human inflammatory bowel disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Disease; Cyclooxygenase 2; Cyclo | 1999 |
The effects of smoking and indomethacin on small intestinal permeability.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Disease; Female; Humans; | 2000 |
Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine, codeine phosphate and prednisolone.
Topics: Codeine; Colitis, Ulcerative; Humans; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Predniso | 1979 |
Loss of interleukin-2-producing intestinal CD4+ T cells in inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; CD4-Positive T-Lymphocytes; Colitis, Ulcerative; Cr | 1991 |
Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat.
Topics: Acetates; Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; | 1990 |
[Cardiac involvement in inflammatory bowel disease].
Topics: Aged; Arrhythmias, Cardiac; Colitis, Ulcerative; Humans; Indomethacin; Male; Myocarditis; Pericardit | 1989 |
In vivo effects of orally administered prednisolone on prostaglandin and leucotriene production in ulcerative colitis.
Topics: Adult; Aged; Colitis, Ulcerative; Dinoprost; Dinoprostone; Female; Humans; Indomethacin; Intestinal | 1987 |
Eicosanoids and the gastrointestinal tract: promising but no verdict yet.
Topics: Biliary Tract Diseases; Colitis, Ulcerative; Digestive System; Eicosanoic Acids; Epoprostenol; Human | 1986 |
Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Cell Fractionation; Cell Line; Cell Nucleus; Coliti | 1985 |
Increased metabolism of arachidonic acid in an immune model of colitis in guinea-pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic | 1985 |
Ankylosing spondylitis.
Topics: Adolescent; Adult; Aortic Valve Insufficiency; Arthritis, Juvenile; Arthritis, Reactive; Colitis, Ul | 1968 |