indomethacin has been researched along with Colitis, Granulomatous in 39 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Excerpt | Relevance | Reference |
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" Rats with indomethacin-induced enteritis were orally administered Rb, Mn, and Zn as tracers." | 7.72 | Use of rubidium, manganese, and zinc as tracers to measure intestinal permeability by PIXE analysis: basal study in an experimental enteritis model. ( Imaseki, H; Joshima, H; Nakao, K; Saito, Y; Suzuki, Y; Tamanoi, I, 2004) |
"Although anti-TNF treatment suppresses inflammation and restores gut barrier function in patients with CD, it does not antagonize the barrier hyperresponsiveness to indomethacin." | 3.73 | Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent. ( Bulteel, V; Noman, M; Rutgeerts, P; Suenaert, P; Van Assche, G; Vermeire, S, 2005) |
" Rats with indomethacin-induced enteritis were orally administered Rb, Mn, and Zn as tracers." | 3.72 | Use of rubidium, manganese, and zinc as tracers to measure intestinal permeability by PIXE analysis: basal study in an experimental enteritis model. ( Imaseki, H; Joshima, H; Nakao, K; Saito, Y; Suzuki, Y; Tamanoi, I, 2004) |
"Ulcerative colitis (UC) and Crohn's disease (CD) are two major forms of inflammatory bowel disease (IBD)." | 1.91 | Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats. ( Gruneck, L; Phunikhom, K; Popluechai, S; Sattayasai, J; Sharpton, TJ; Thipart, K, 2023) |
"Crohn's disease is a type of inflammatory bowel disease of unknown etiology." | 1.51 | Elemental Diet Regulates Intestinal Permeability and Antibody Production in Indomethacin-Induced Intestinal Injury Rats. ( Akahoshi, A; Kikuchi, Y; Matsuo, M; Minami, H; Nabeta, C, 2019) |
"Crohn's disease is a common inflammatory manifestation in humans and other animal species relating to the ulceration and digestive disturbances in upper gastro-intestinal tract." | 1.43 | Emu oil offers protection in Crohn's disease model in rats. ( Pandiyan, V; Selvasubramanian, S; Vemu, B, 2016) |
"Treatment with sulfasalazine, low dose of natrexone or their combination resulted in significant improvement of all measured parameters compared with enteritis group." | 1.43 | Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats. ( Abdel-Salam, LO; Kamel, MM; Khattab, A; Osman, AS; Tawfik, DI; Tolba, HM, 2016) |
" Teduglutide, a recombinant human GLP2 variant (GLP2-2G), has increased half-life and stability as compared to the native GLP2 peptide, but still requires twice daily dosing in preclinical models and daily dosing in the clinic." | 1.38 | GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model. ( Alters, SE; Lachinyan, T; McLaughlin, B; Podust, V; Schellenberger, V; Spink, B; Stemmer, WP; Wang, CW, 2012) |
"First, patients with quiescent Crohn's disease and ulcerative colitis received the non-NSAID analgesic acetaminophen (n = 26) and the conventional NSAIDs naproxen (n = 32), diclofenac (n = 29), and indomethacin (n = 22) for 4 weeks." | 1.33 | Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. ( Bjarnason, I; Bjornsson, E; Maiden, L; Premchand, P; Sherwood, R; Smale, S; Takeuchi, K; Thjodleifsson, B, 2006) |
" Pinane thromboxane, a selective thromboxane synthase inhibitor and receptor blocker, inhibited OxAA stimulation of TXB(2) and IL-8 in a dose-response manner." | 1.32 | Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites. ( Alzoghaibi, MA; Fowler, AA; Graham, MF; Walsh, SW; Willey, A; Yager, DR, 2004) |
"Both Crohn's disease ileal ulcers and indomethacin-induced jejunal ulcers in the rat have a predilection for the mesenteric margin of the bowel wall." | 1.31 | Similarities between ileal Crohn's disease and indomethacin experimental jejunal ulcers in the rat. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 2000) |
"Metronidazole was more potent than amoxicillin/clavulanic acid and anti-tumour necrosis factor in improving the indometacin-induced small bowel inflammation." | 1.31 | Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model. ( Ceuppens, JL; Colpaert, S; De Greef, B; Geboes, K; Liu, Z; Rutgeerts, P, 2001) |
"Crohn's disease (CD) and ulcerative colitis (UC) represent clinically distinct chronic inflammatory bowel diseases (IBD) of unknown etiology." | 1.29 | Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis. ( Gurbindo, C; Justinich, C; Marchand, R; Menezes, J; Sabbah, S; Seidman, EG, 1993) |
"Finally, supernatants from Crohn's disease and ulcerative colitis cell cultures failed to suppress interleukin-2 production by control CD4+ T cells." | 1.28 | Loss of interleukin-2-producing intestinal CD4+ T cells in inflammatory bowel disease. ( Fiocchi, C; Kusugami, K; Matsuura, T; Rachmilewitz, D; West, GA; Youngman, KR, 1991) |
"Patients with colitis or ileocolitis were more likely to suffer from ocular inflammation (23." | 1.28 | Ocular inflammation in Crohn's disease. ( Murray, AD; Salmon, JF; Wright, JP, 1991) |
"One patient had ulcerative colitis, while two patients had Crohn's disease." | 1.27 | Pleuropericarditis: an extraintestinal complication of inflammatory bowel disease. Report of three cases and review of literature. ( Brewster, AC; Darrah, JJ; Heilpern, RJ; Patwardhan, RV, 1983) |
"Mucosal tissue of patients with Crohn's disease synthesized considerably more LTB4 and sulfidopeptide-leukotrienes than non-inflamed mucosa." | 1.27 | [Leukotriene synthesis by gastrointestinal tissue and its pharmacologic modification]. ( Dreyling, KW; Hoppe, U; Kozuschek, W; Morgenroth, K; Peskar, BA; Peskar, BM, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 11 (28.21) | 18.7374 |
1990's | 8 (20.51) | 18.2507 |
2000's | 13 (33.33) | 29.6817 |
2010's | 6 (15.38) | 24.3611 |
2020's | 1 (2.56) | 2.80 |
Authors | Studies |
---|---|
Thipart, K | 2 |
Gruneck, L | 2 |
Phunikhom, K | 2 |
Sharpton, TJ | 2 |
Sattayasai, J | 2 |
Popluechai, S | 2 |
Kikuchi, Y | 1 |
Matsuo, M | 1 |
Nabeta, C | 1 |
Akahoshi, A | 1 |
Minami, H | 2 |
Alters, SE | 2 |
McLaughlin, B | 2 |
Spink, B | 2 |
Lachinyan, T | 2 |
Wang, CW | 2 |
Podust, V | 2 |
Schellenberger, V | 2 |
Stemmer, WP | 2 |
Vemu, B | 1 |
Selvasubramanian, S | 1 |
Pandiyan, V | 1 |
Simon, H | 1 |
Fischer, T | 1 |
Almási, A | 1 |
Fischer, E | 1 |
Tawfik, DI | 1 |
Osman, AS | 1 |
Tolba, HM | 1 |
Khattab, A | 1 |
Abdel-Salam, LO | 1 |
Kamel, MM | 1 |
Jeffers, M | 1 |
McDonald, WF | 1 |
Chillakuru, RA | 1 |
Yang, M | 1 |
Nakase, H | 1 |
Deegler, LL | 1 |
Sylander, ED | 1 |
Rittman, B | 1 |
Bendele, A | 1 |
Sartor, RB | 1 |
Lichenstein, HS | 1 |
Houchen, CW | 1 |
Ruh, J | 1 |
Schmidt, E | 1 |
Gebhard, MM | 1 |
Klar, E | 1 |
Glaser, F | 1 |
Herfarth, C | 1 |
Krieglstein, CF | 1 |
Anthoni, C | 1 |
Laukötter, MG | 1 |
Spiegel, HU | 1 |
Schmid, KW | 1 |
Schürmann, G | 1 |
Alzoghaibi, MA | 1 |
Walsh, SW | 1 |
Willey, A | 1 |
Yager, DR | 1 |
Fowler, AA | 1 |
Graham, MF | 1 |
Nakao, K | 1 |
Suzuki, Y | 1 |
Imaseki, H | 1 |
Joshima, H | 1 |
Tamanoi, I | 1 |
Saito, Y | 1 |
Suenaert, P | 2 |
Bulteel, V | 2 |
Vermeire, S | 1 |
Noman, M | 1 |
Van Assche, G | 1 |
Rutgeerts, P | 4 |
Suzuki, H | 1 |
Hanyou, N | 1 |
Sonaka, I | 1 |
Takeuchi, K | 1 |
Smale, S | 1 |
Premchand, P | 1 |
Maiden, L | 1 |
Sherwood, R | 1 |
Thjodleifsson, B | 1 |
Bjornsson, E | 1 |
Bjarnason, I | 1 |
Sido, B | 1 |
Seel, C | 1 |
Hochlehnert, A | 1 |
Breitkreutz, R | 1 |
Dröge, W | 1 |
Klopcic, B | 1 |
Appelbee, A | 1 |
Raye, W | 1 |
Lloyd, F | 1 |
Jooste, JC | 1 |
Forrest, CH | 1 |
Lawrance, IC | 1 |
Cury, DH | 1 |
Costa, JE | 1 |
Irika, K | 1 |
Mijji, L | 1 |
Garcez, A | 1 |
Buchiguel, C | 1 |
Silva, I | 1 |
Sipahi, A | 1 |
Holdstock, G | 2 |
Chastenay, BF | 1 |
Krawitt, EL | 2 |
Ershler, WB | 1 |
Victorino, RM | 1 |
Patwardhan, RV | 1 |
Heilpern, RJ | 1 |
Brewster, AC | 1 |
Darrah, JJ | 1 |
Goodacre, RL | 1 |
Bienenstock, J | 1 |
D'Haens, G | 1 |
Hiele, M | 2 |
Geboes, K | 2 |
Ceuppens, JL | 2 |
Gurbindo, C | 1 |
Sabbah, S | 1 |
Menezes, J | 1 |
Justinich, C | 1 |
Marchand, R | 1 |
Seidman, EG | 1 |
Duda, SH | 1 |
Raible, RT | 1 |
Risler, T | 1 |
Huppert, PE | 1 |
Brambs, HJ | 1 |
Gregor, M | 1 |
McCartney, SA | 1 |
Mitchell, JA | 1 |
Fairclough, PD | 1 |
Farthing, MJ | 1 |
Warner, TD | 1 |
Anthony, A | 1 |
Pounder, RE | 1 |
Dhillon, AP | 1 |
Wakefield, AJ | 1 |
Den Hond, E | 1 |
Peeters, M | 1 |
Monsuur, F | 1 |
Ghoos, Y | 1 |
Colpaert, S | 1 |
Liu, Z | 1 |
De Greef, B | 1 |
Kusugami, K | 1 |
Matsuura, T | 1 |
West, GA | 1 |
Youngman, KR | 2 |
Rachmilewitz, D | 1 |
Fiocchi, C | 2 |
Salmon, JF | 1 |
Wright, JP | 1 |
Murray, AD | 1 |
Holman, RT | 1 |
Peskar, BM | 1 |
Kozuschek, W | 1 |
Morgenroth, K | 1 |
Hoppe, U | 1 |
Dreyling, KW | 1 |
Peskar, BA | 1 |
Miura, M | 1 |
Hiwatashi, N | 1 |
Tubbs, RR | 1 |
Hart, FD | 1 |
Fusco, FA | 1 |
Azzolini, A | 1 |
Dolcino, G | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Evaluation of Free Aminoacids in Saliva as A Diagnostic Biomarker of Periodontal Disease[NCT04642716] | 60 participants (Actual) | Interventional | 2015-04-20 | Completed | |||
Effect of High Omega-3 Fish Intake on Lipid Peroxidation[NCT01183520] | 30 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for indomethacin and Colitis, Granulomatous
Article | Year |
---|---|
Control of polyunsaturated acids in tissue lipids.
Topics: Acrodermatitis; alpha-Linolenic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Child; Crohn Dis | 1986 |
38 other studies available for indomethacin and Colitis, Granulomatous
Article | Year |
---|---|
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
Topics: Acetic Acid; Animals; Anthocyanins; Bacteria; Colitis, Ulcerative; Crohn Disease; Gastrointestinal M | 2023 |
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
Topics: Acetic Acid; Animals; Anthocyanins; Bacteria; Colitis, Ulcerative; Crohn Disease; Gastrointestinal M | 2023 |
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
Topics: Acetic Acid; Animals; Anthocyanins; Bacteria; Colitis, Ulcerative; Crohn Disease; Gastrointestinal M | 2023 |
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
Topics: Acetic Acid; Animals; Anthocyanins; Bacteria; Colitis, Ulcerative; Crohn Disease; Gastrointestinal M | 2023 |
Elemental Diet Regulates Intestinal Permeability and Antibody Production in Indomethacin-Induced Intestinal Injury Rats.
Topics: Animals; Antibody Formation; Crohn Disease; Disease Models, Animal; Food, Formulated; Indomethacin; | 2019 |
GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's. PLoS One. 2012; 7(11): e50630.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; Disease Models, Animal; Glucagon-Li | 2013 |
Emu oil offers protection in Crohn's disease model in rats.
Topics: Aloe; Animals; Antioxidants; Cecum; Crohn Disease; Disease Models, Animal; Female; Ileum; Indomethac | 2016 |
Effects of Mesalazine on Morphological and Functional Changes in the Indomethacin-Induced Inflammatory Bowel Disease (Rat Model of Crohn's Disease).
Topics: Animals; Crohn Disease; Disease Models, Animal; Glucuronates; Indomethacin; Inflammation; Inflammato | 2017 |
Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats.
Topics: Animals; Crohn Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Comb | 2016 |
GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model.
Topics: Animals; Crohn Disease; Disease Models, Animal; Female; Glucagon-Like Peptide 2; Humans; Indomethaci | 2012 |
A novel human fibroblast growth factor treats experimental intestinal inflammation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Ce | 2002 |
FGF-20: FGFs--they keep growing and growing and growing!
Topics: Animals; Colitis, Ulcerative; Crohn Disease; Dinoprostone; Disease Models, Animal; Epithelial Cells; | 2003 |
[Effect of mast cell activation on microcirculation of intestinal mucosa in inflamed small intestine of the rat].
Topics: Animals; Blood Flow Velocity; Crohn Disease; Disease Models, Animal; Histamine H1 Antagonists; Hista | 1998 |
[Measuring blood flow velocity in healthy and indomethacin-induced inflammation in rat small intestine serosa with FITC-marked erythrocytes].
Topics: Animals; Blood Flow Velocity; Crohn Disease; Erythrocytes; Indomethacin; Intestinal Mucosa; Leukocyt | 1998 |
Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites.
Topics: Arachidonic Acid; Blotting, Western; Cells, Cultured; Crohn Disease; Cyclooxygenase Inhibitors; Gene | 2004 |
Use of rubidium, manganese, and zinc as tracers to measure intestinal permeability by PIXE analysis: basal study in an experimental enteritis model.
Topics: Animals; Crohn Disease; Enteritis; Indomethacin; Inflammation; Intestinal Absorption; Intestine, Sma | 2004 |
Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Case-Control Studies; Crohn | 2005 |
An elemental diet controls inflammation in indomethacin-induced small bowel disease in rats: the role of low dietary fat and the elimination of dietary proteins.
Topics: Animals; Crohn Disease; Dietary Proteins; Disease Models, Animal; Food, Formulated; Gastrointestinal | 2005 |
Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colitis, Ul | 2006 |
Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation?
Topics: Adult; Animals; Case-Control Studies; Colon; Crohn Disease; Dietary Supplements; Disease Models, Ani | 2006 |
Indomethacin and retinoic acid modify mouse intestinal inflammation and fibrosis: a role for SPARC.
Topics: Animals; Crohn Disease; Disease Models, Animal; Female; Fibrosis; Immunoenzyme Techniques; Indometha | 2008 |
Protective effect of octreotide and infliximab in an experimental model of indomethacin-induced inflammatory bowel disease.
Topics: Animals; Antibodies, Monoclonal; Cell Membrane Permeability; Crohn Disease; Disease Models, Animal; | 2008 |
Increased suppressor cell activity in inflammatory bowel disease.
Topics: Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Humans; Hydrocortisone; In Vitro Technique | 1981 |
Defective lymphocyte IgA production in inflammatory bowel disease.
Topics: Adolescent; Adult; Antibody-Producing Cells; Child; Colitis, Ulcerative; Crohn Disease; Female; Huma | 1982 |
Indomethacin sensitive suppressor cells in Crohn's disease: a possible role in decreased lymphocyte responsiveness.
Topics: Adult; Aged; Crohn Disease; Dose-Response Relationship, Immunologic; Female; Humans; Indomethacin; L | 1983 |
Pleuropericarditis: an extraintestinal complication of inflammatory bowel disease. Report of three cases and review of literature.
Topics: Adult; Aspirin; Colitis, Ulcerative; Crohn Disease; Humans; Indomethacin; Male; Middle Aged; Pericar | 1983 |
Reduced suppressor cell activity in intestinal lymphocytes from patients with Crohn's disease.
Topics: Cimetidine; Crohn Disease; Humans; Indomethacin; Intestinal Mucosa; Lymphocyte Activation; Lymphocyt | 1982 |
Depressed T cell reactivity to recall antigens in Crohn's disease before and after surgical resection.
Topics: Adult; Aged; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Cell Division; Crohn Disease; Dinoprostone; | 1994 |
Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis.
Topics: Adolescent; Cell Division; Child; Colitis, Ulcerative; Colon; Crohn Disease; Flow Cytometry; Humans; | 1993 |
[Therapeutic bilateral renal artery embolization in the nephrotic syndrome].
Topics: Amyloidosis; Captopril; Cardiomyopathies; Contraindications; Creatinine; Crohn Disease; Drug Therapy | 1994 |
Selective COX-2 inhibitors and human inflammatory bowel disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Disease; Cyclooxygenase 2; Cyclo | 1999 |
Similarities between ileal Crohn's disease and indomethacin experimental jejunal ulcers in the rat.
Topics: Animals; Crohn Disease; Humans; Ileum; Indomethacin; Intestine, Small; Jejunal Diseases; Male; Mesen | 2000 |
The effects of smoking and indomethacin on small intestinal permeability.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Disease; Female; Humans; | 2000 |
Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model.
Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age | 2001 |
Loss of interleukin-2-producing intestinal CD4+ T cells in inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; CD4-Positive T-Lymphocytes; Colitis, Ulcerative; Cr | 1991 |
Ocular inflammation in Crohn's disease.
Topics: Adolescent; Adult; Aged; Anterior Eye Segment; Anti-Inflammatory Agents, Non-Steroidal; Child; Colit | 1991 |
[Leukotriene synthesis by gastrointestinal tissue and its pharmacologic modification].
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatography | 1986 |
Mitogenic response and interleukin 2 production in Crohn's disease.
Topics: Concanavalin A; Crohn Disease; Humans; Indomethacin; Interleukin-2; Leukocytes, Mononuclear; Lymphoc | 1987 |
Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Cell Fractionation; Cell Line; Cell Nucleus; Coliti | 1985 |
Ankylosing spondylitis.
Topics: Adolescent; Adult; Aortic Valve Insufficiency; Arthritis, Juvenile; Arthritis, Reactive; Colitis, Ul | 1968 |
[Clinical observations on the treatment of rheumatic diseases and other morbid states with indomethacin].
Topics: Anemia, Hemolytic, Autoimmune; Arthritis, Rheumatoid; Asthma; Crohn Disease; Dexamethasone; Hodgkin | 1966 |