Page last updated: 2024-10-29

indomethacin and Cognition Disorders

indomethacin has been researched along with Cognition Disorders in 9 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g)."5.09Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. ( Davis, P; Moddemann, D; Ohlsson, A; Roberts, RS; Saigal, S; Schmidt, B; Solimano, A; Vincer, M; Wright, LL, 2001)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's6 (66.67)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tarantini, S2
Yabluchanksiy, A1
Fülöp, GA1
Hertelendy, P2
Valcarcel-Ares, MN2
Kiss, T1
Bagwell, JM1
O'Connor, D1
Farkas, E2
Sorond, F1
Csiszar, A2
Ungvari, Z2
Tucsek, Z1
Smith, N1
Menyhart, A1
Hodges, EL1
Towner, R1
Deak, F1
Sonntag, WE1
Toth, P1
Luu, TM1
Ment, LR3
Schneider, KC3
Katz, KH3
Allan, WC1
Vohr, BR1
Schmidt, B3
Asztalos, EV1
Roberts, RS3
Robertson, CM1
Sauve, RS1
Whitfield, MF1
Peterson, BS1
Meltzer, JA1
Vohr, B2
Allan, W1
Lacadie, C1
Duncan, CC1
Makuch, RW2
Constable, RT2
Kabra, NS1
Doyle, LW1
Papile, L1
Fanaroff, A1
Kesler, SR1
Reiss, AL1
Watson, C1
Maller-Kesselman, J1
Silbereis, J1
Dal Forno, G1
Kawas, CH1
Davis, P1
Moddemann, D1
Ohlsson, A1
Saigal, S1
Solimano, A1
Vincer, M1
Wright, LL1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)[NCT00009646]Phase 31,202 participants (Actual)Interventional1993-11-30Completed
Lactoferrin Infant Feeding Trial - LIFT_Canada[NCT03367013]Phase 3453 participants (Actual)Interventional2018-02-16Active, not recruiting
Enteral Supplementation With High-dose Docosahexaenoic Acid on the Risk for Bronchopulmonary Dysplasia in Very Preterm Infants: A Collaborative Study Protocol for an Individual Participant Data Meta-analysis[NCT05915806]1,801 participants (Actual)Interventional2023-07-30Active, not recruiting
Clinical Research on the Predictive Effect of Neonatal Morbidities on the Poor Outcomes to Very Low Birth-weight and Extremely Low Birth-weight Infants[NCT03104946]834 participants (Actual)Observational2013-09-01Completed
Randomized Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial[NCT00033917]Phase 3630 participants (Actual)Interventional1989-09-30Completed
The United States Patent Ductus Arteriosus Registry[NCT04205877]5,000 participants (Anticipated)Observational2020-01-01Not yet recruiting
High-Dose Erythropoietin in Very Low Birth Weight Infants for the Potential Treatment of Prematurity-Related Cerebral Hemorrhagic-Ischemic Injury: A Phase II Safety/Tolerability Study[NCT00589953]Phase 222 participants (Actual)Interventional2007-07-31Terminated
Follow-up Visit of High Risk Infants[NCT00009633]68,000 participants (Anticipated)Observational1993-01-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

IVH at 5 Postnatal Days

Cranial ultrasounds were performed daily for the first 5 postnatal days; the main outcome measure was intraaventricular hemorrhage (IVH) at 5 days of age (NCT00033917)
Timeframe: at 5 days

InterventionIVH (Number)
Indomethacin25
Placebo40

Language Outcome

"Peabody Picture Vocabulary Test (PPVT) This is a semantic language test. The mean value is 100; standard deviation is 16 points. A higher score means better language; a lower score means poorer language.~There are no subscales to the PPVT. The measurement unit is points on a scale. A score < 70 indicates severely abnormal language function." (NCT00033917)
Timeframe: at 8 years

Interventionparticipants with PPVT score < 70 (Number)
Indomethacin - no IVH12
Indomethacin - IVH5
Placebo - no IVH24
Placebo - IVH7

Reviews

1 review available for indomethacin and Cognition Disorders

ArticleYear
Cognitive problems in the elderly.
    Current opinion in neurology, 1995, Volume: 8, Issue:4

    Topics: Aged; Alzheimer Disease; Cognition Disorders; Dementia; Humans; Indomethacin; Mental Recall; Neurops

1995

Trials

6 trials available for indomethacin and Cognition Disorders

ArticleYear
Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age.
    Pediatrics, 2009, Volume: 123, Issue:3

    Topics: Brain Damage, Chronic; Cerebral Ventricles; Child; Child Behavior Disorders; Child, Preschool; Cogni

2009
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms.
    JAMA, 2003, Mar-05, Volume: 289, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blindness; Brain Diseases; Bronchopulmonary Dysplasia; Cere

2003
A functional magnetic resonance imaging study of the long-term influences of early indomethacin exposure on language processing in the brains of prematurely born children.
    Pediatrics, 2006, Volume: 118, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain; Child; Cognition Disorders; Cohort Studies; Female;

2006
Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms.
    The Journal of pediatrics, 2007, Volume: 150, Issue:3

    Topics: Cognition Disorders; Ductus Arteriosus, Patent; Echocardiography, Doppler; Female; Follow-Up Studies

2007
Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms.
    The Journal of pediatrics, 2007, Volume: 150, Issue:3

    Topics: Cognition Disorders; Ductus Arteriosus, Patent; Echocardiography, Doppler; Female; Follow-Up Studies

2007
Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms.
    The Journal of pediatrics, 2007, Volume: 150, Issue:3

    Topics: Cognition Disorders; Ductus Arteriosus, Patent; Echocardiography, Doppler; Female; Follow-Up Studies

2007
Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms.
    The Journal of pediatrics, 2007, Volume: 150, Issue:3

    Topics: Cognition Disorders; Ductus Arteriosus, Patent; Echocardiography, Doppler; Female; Follow-Up Studies

2007
Brain volume reductions within multiple cognitive systems in male preterm children at age twelve.
    The Journal of pediatrics, 2008, Volume: 152, Issue:4

    Topics: Birth Weight; Brain; Case-Control Studies; Cerebral Hemorrhage; Child; Cognition Disorders; Female;

2008
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001

Other Studies

2 other studies available for indomethacin and Cognition Disorders

ArticleYear
Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.
    GeroScience, 2017, Volume: 39, Issue:5-6

    Topics: Animals; Cerebrovascular Circulation; Cognition Disorders; Cyclooxygenase Inhibitors; Disease Models

2017
Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Volume: 35, Issue:11

    Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Cognition Disorders; Cyclooxygenase Inhibitors

2015