indomethacin has been researched along with Cocarcinogenesis in 12 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Cocarcinogenesis: The combination of two or more different factors in the production of cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relevance of p53 mutations to rat bladder cancer progression induced by a single injection of N-methyl-N-nitrosourea (MNU) and the chemopreventive effects of indomethacin (IM) were investigated in male F344 rats, initially given N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at a dose of 500 ppm in the drinking water for 10 weeks." | 3.69 | Lack of involvement of p53 gene mutations in N-methyl-N-nitrosourea-induced bladder tumor progression in N-butyl-N-(4-hydroxybutyl)nitrosamine-treated rats and no suppression by indomethacin. ( Kawabe, M; Orita, SI; Ozaki, M; Shibata, MA; Shirai, T; Takahashi, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Imai, T | 1 |
| Onose, J | 1 |
| Hasumura, M | 1 |
| Takizawa, T | 1 |
| Hirose, M | 1 |
| Milman, HA | 1 |
| Fürstenberger, G | 3 |
| Richter, H | 2 |
| Argyris, TS | 1 |
| Marks, F | 3 |
| Boutwell, RK | 1 |
| Verma, AK | 1 |
| Ashendel, CL | 1 |
| Astrup, E | 1 |
| Berry, DL | 1 |
| Bertsch, S | 1 |
| Holmäng, S | 1 |
| Cano, M | 1 |
| Grenabo, L | 1 |
| Hedelin, H | 1 |
| Johansson, SL | 1 |
| Ozaki, M | 1 |
| Shibata, MA | 1 |
| Takahashi, S | 1 |
| Orita, SI | 1 |
| Kawabe, M | 1 |
| Shirai, T | 1 |
| Gross, M | 1 |
| Hagiwara, A | 2 |
| Diwan, BA | 1 |
| Ward, JM | 1 |
| Kurata, Y | 1 |
| Asamoto, M | 1 |
| Masui, T | 1 |
| Fukushima, S | 1 |
| Koike, M | 1 |
| Nakazawa, S | 1 |
| Ozawa, T | 1 |
| Narisawa, T | 1 |
| Hosaka, S | 1 |
| Niwa, M | 1 |
2 reviews available for indomethacin and Cocarcinogenesis
| Article | Year |
|---|---|
Possible contribution of indomethacin to the carcinogenicity of nongenotoxic bladder carcinogens that cause bladder calculi.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclooxygenase Inhibitors; | 2007 |
Mouse skin: a useful model system for studying the mechanism of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Carcinogens; Cell Communication; Cell | 1982 |
10 other studies available for indomethacin and Cocarcinogenesis
| Article | Year |
|---|---|
Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Amitrole; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Carcinogens; Cocarcinogenes | 2006 |
Effects of the phorbol ester 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo: evidence for its uselessness as a negative control compound in studies on the biological effects of phorbol ester tumor promoters.
Topics: Animals; Cell Division; Cocarcinogenesis; Cyclic AMP; Epidermis; Female; Growth Inhibitors; Indometh | 1982 |
On the relationship between epidermal hyperproliferation and skin tumor promotion.
Topics: Calcimycin; Cell Division; Cocarcinogenesis; Dinoprost; Dinoprostone; Epidermal Cells; Hyperplasia; | 1982 |
Effect of indomethacin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced urinary tract carcinogenesis.
Topics: Animals; Body Weight; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cocarcinogenesis; Drug | 1995 |
Lack of involvement of p53 gene mutations in N-methyl-N-nitrosourea-induced bladder tumor progression in N-butyl-N-(4-hydroxybutyl)nitrosamine-treated rats and no suppression by indomethacin.
Topics: Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Carcinogens; Carcinoma, Transitional | 1997 |
Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion).
Topics: Animals; Cocarcinogenesis; Dinoprost; Dinoprostone; Epidermis; Indomethacin; Mice; Papilloma; Phorbo | 1989 |
Modifying effects of butylated hydroxyanisole, di(2-ethylhexyl)phthalate or indomethacin on mouse hepatocarcinogenesis initiated by N-nitrosodiethylamine.
Topics: Adenoma; Animals; Butylated Hydroxyanisole; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosa | 1986 |
Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Topics: Acetaminophen; Allopurinol; Aminocaproates; Animals; Biphenyl Compounds; Butylhydroxybutylnitrosamin | 1986 |
[Investigation of endogenous prostaglandins in 1,2-dimethyl-hydrazine induced colonic cancer in rats--inhibition of proliferation in colonic cancer with indomethacin treatment].
Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Indomethacin; Methylhydrazines; Pr | 1986 |
Prostaglandin E2 counteracts the inhibition by indomethacin of rat colon ornithine decarboxylase induction by deoxycholic acid.
Topics: Animals; Cocarcinogenesis; Colon; Colonic Neoplasms; Deoxycholic Acid; Dinoprostone; Enzyme Inductio | 1985 |