indomethacin has been researched along with Clostridioides difficile Infection in 2 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin administration caused weight loss, increased the signs of severe infection and worsened histopathological damage, leading to 100% mortality during CDI." | 3.88 | Indomethacin increases severity of Clostridium difficile infection in mouse model. ( Aronoff, DM; Bergin, IL; Castro-Córdova, P; Gil, F; Kirk, LA; Muñoz-Miralles, J; Paredes-Sabja, D; Trindade, BC, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muñoz-Miralles, J | 1 |
| Trindade, BC | 1 |
| Castro-Córdova, P | 1 |
| Bergin, IL | 1 |
| Kirk, LA | 1 |
| Gil, F | 1 |
| Aronoff, DM | 2 |
| Paredes-Sabja, D | 1 |
| Maseda, D | 1 |
| Zackular, JP | 1 |
| Trindade, B | 1 |
| Kirk, L | 1 |
| Roxas, JL | 1 |
| Rogers, LM | 1 |
| Washington, MK | 1 |
| Du, L | 1 |
| Koyama, T | 1 |
| Viswanathan, VK | 1 |
| Vedantam, G | 1 |
| Schloss, PD | 1 |
| Crofford, LJ | 1 |
| Skaar, EP | 1 |
2 other studies available for indomethacin and Clostridioides difficile Infection
| Article | Year |
|---|---|
Indomethacin increases severity of Clostridium difficile infection in mouse model.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Clostridioides difficile; C | 2018 |
Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD4-Positive T-Lymphocytes; Clostridium Infections | 2019 |