indomethacin has been researched along with Cleft Palate in 3 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arachidonic acid produces a significant reversal of the production of cleft palate by cortisone in the offspring of sensitive strains of mice in vivo." | 3.66 | Further evidence for a role of arachidonic acid in glucocorticoid teratogenic action in the palate. ( Goldman, AS; Herold, R; Piddington, R, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Piddington, R | 1 |
| Herold, R | 1 |
| Goldman, AS | 1 |
| Montenegro, MA | 2 |
| Palomino, H | 2 |
3 other studies available for indomethacin and Cleft Palate
| Article | Year |
|---|---|
Further evidence for a role of arachidonic acid in glucocorticoid teratogenic action in the palate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cleft Palate; Cortisone; Female; Hydr | 1983 |
Induction of cleft palate in mice by inhibitors of prostaglandin synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cleft Palate; Diclofenac; Female; Indomethacin; In | 1990 |
Inhibition of palatal fusion in vitro by indomethacin in two strains of mice with different H-2 backgrounds.
Topics: Animals; Cleft Palate; Dinoprostone; Disease Susceptibility; Haplotypes; Indomethacin; Major Histoco | 1989 |