Page last updated: 2024-10-29

indomethacin and Cirrhosis

indomethacin has been researched along with Cirrhosis in 10 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"Indomethacin caused microcytic anaemia, hypoalbuminaemia, small intestinal ulceration, caecal ulceration and inconspicuous raised mucosal lesions in the caecum that histologically showed submucosal fibrosis with disruption and thickening of the apical muscularis mucosae."9.07Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with indomethacin. ( Anthony, A; Dhillon, AP; Nygard, G; Pounder, RE; Sim, R; Wakefield, AJ, 1994)
"We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation."7.72Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003)
" Whether this perivascular and interstitial fibrosis is a direct effect of AngII on collagen turnover of these cells or an indirect response mediated by nitric oxide, prostaglandins and/or bradykinin released in response to AngII, is uncertain."7.69Angiotensin II-induced myocardial fibrosis in rats: role of nitric oxide, prostaglandins and bradykinin. ( Campbell, SE; Sigusch, HH; Weber, KT, 1996)
"Indomethacin caused microcytic anaemia, hypoalbuminaemia, small intestinal ulceration, caecal ulceration and inconspicuous raised mucosal lesions in the caecum that histologically showed submucosal fibrosis with disruption and thickening of the apical muscularis mucosae."5.07Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with indomethacin. ( Anthony, A; Dhillon, AP; Nygard, G; Pounder, RE; Sim, R; Wakefield, AJ, 1994)
"We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation."3.72Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003)
"There were significant fibrosis and inflammatory infiltration in the myocardium and blood vessels, represented by higher hydroxyproline and collagen volume fraction, and a large amount of inflammatory cells in the tissues of SAD rats."3.72Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. ( Chen, H; Shu, H; Su, DF; Xie, HH; Yuan, WJ; Zhang, C, 2003)
" Whether this perivascular and interstitial fibrosis is a direct effect of AngII on collagen turnover of these cells or an indirect response mediated by nitric oxide, prostaglandins and/or bradykinin released in response to AngII, is uncertain."3.69Angiotensin II-induced myocardial fibrosis in rats: role of nitric oxide, prostaglandins and bradykinin. ( Campbell, SE; Sigusch, HH; Weber, KT, 1996)
" The administration of antiinflammatory drugs resulted at some laser intensities in increased scores of maximum wound area, healing time, cumulated wound area, fibrosis, hydroxyproline, and hydroxylysine, being mostly pronounced for indomethacin at 0."3.68Laser induced wounds and scarring modified by antiinflammatory drugs: a murine model. ( Haedersdal, M; Poulsen, T; Wulf, HC, 1993)
"CSA hypertension was associated with renal perivascular fibrosis and divergent changes in immunohistochemical signals of renal arteriolar ETA (increases) and ETB (decreases) receptors."1.42Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling. ( Ali, RM; El-Gowelli, HM; El-Mas, MM; Helmy, MW, 2015)
"Increased bone resorption was present in LIF-treated hemicalvaria compared with that in the noninjected hemicalvaria or calvaria from mice injected with vehicle alone at both 6 and 13 days."1.29The effect of leukemia inhibitory factor on bone in vivo. ( Callon, K; Cornish, J; Edgar, S; King, A; Reid, IR, 1993)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's5 (50.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
El-Mas, MM1
Helmy, MW1
Ali, RM1
El-Gowelli, HM1
Amagase, K1
Yokota, M1
Tsukimi, Y1
Okabe, S1
Zhang, C1
Chen, H1
Xie, HH1
Shu, H1
Yuan, WJ1
Su, DF1
Saito, A1
Okazaki, H1
Sugawara, I1
Yamamoto, K1
Takizawa, H1
Klopcic, B1
Appelbee, A1
Raye, W1
Lloyd, F1
Jooste, JC1
Forrest, CH1
Lawrance, IC1
Anthony, A1
Dhillon, AP1
Sim, R1
Nygard, G1
Pounder, RE1
Wakefield, AJ1
Haedersdal, M1
Poulsen, T1
Wulf, HC1
Cornish, J1
Callon, K1
King, A1
Edgar, S1
Reid, IR1
Sigusch, HH1
Campbell, SE1
Weber, KT1
Han, DS1
Li, F1
Holt, L1
Connolly, K1
Hubert, M1
Miceli, R1
Okoye, Z1
Santiago, G1
Windle, K1
Wong, E1
Sartor, RB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Dexmedetomidine on Levels of Plasma Inflammatory Factor in Asthma Patients Undergoing General Anesthesia-single Center,Randomized,Double-blind,Controlled Trial[NCT02289391]Phase 480 participants (Anticipated)Interventional2014-12-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for indomethacin and Cirrhosis

ArticleYear
Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with indomethacin.
    Alimentary pharmacology & therapeutics, 1994, Volume: 8, Issue:4

    Topics: Administration, Oral; Anemia, Iron-Deficiency; Animals; Cecal Diseases; Cecum; Fibrosis; Indomethaci

1994

Other Studies

9 other studies available for indomethacin and Cirrhosis

ArticleYear
Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling.
    Toxicology and applied pharmacology, 2015, Apr-01, Volume: 284, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclosporine; Cytoprote

2015
Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2003, Volume: 54, Issue:3

    Topics: Acetic Acid; Animals; Dinoprostone; Disease Models, Animal; Drug Administration Schedule; Fibrosis;

2003
Inflammation is involved in the organ damage induced by sinoaortic denervation in rats.
    Journal of hypertension, 2003, Volume: 21, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aorta; Blood Vessels; Cardiomegaly;

2003
Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro.
    International archives of allergy and immunology, 2003, Volume: 132, Issue:2

    Topics: Actins; Cell Differentiation; Cell Division; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Di

2003
Indomethacin and retinoic acid modify mouse intestinal inflammation and fibrosis: a role for SPARC.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:6

    Topics: Animals; Crohn Disease; Disease Models, Animal; Female; Fibrosis; Immunoenzyme Techniques; Indometha

2008
Laser induced wounds and scarring modified by antiinflammatory drugs: a murine model.
    Lasers in surgery and medicine, 1993, Volume: 13, Issue:1

    Topics: Administration, Oral; Animals; Burns; Cicatrix; Dose-Response Relationship, Radiation; Female; Fibro

1993
The effect of leukemia inhibitory factor on bone in vivo.
    Endocrinology, 1993, Volume: 132, Issue:3

    Topics: Animals; Bone and Bones; Bone Development; Bone Resorption; Fibrosis; Growth Inhibitors; Indomethaci

1993
Angiotensin II-induced myocardial fibrosis in rats: role of nitric oxide, prostaglandins and bradykinin.
    Cardiovascular research, 1996, Volume: 31, Issue:4

    Topics: Angiotensin II; Animals; Arginine; Bradykinin; Bradykinin Receptor Antagonists; Collagen; Cyclooxyge

1996
Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:5

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cell Division; Chroni

2000