indomethacin has been researched along with Cirrhosis in 10 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin caused microcytic anaemia, hypoalbuminaemia, small intestinal ulceration, caecal ulceration and inconspicuous raised mucosal lesions in the caecum that histologically showed submucosal fibrosis with disruption and thickening of the apical muscularis mucosae." | 9.07 | Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with indomethacin. ( Anthony, A; Dhillon, AP; Nygard, G; Pounder, RE; Sim, R; Wakefield, AJ, 1994) |
| "We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation." | 7.72 | Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003) |
| " Whether this perivascular and interstitial fibrosis is a direct effect of AngII on collagen turnover of these cells or an indirect response mediated by nitric oxide, prostaglandins and/or bradykinin released in response to AngII, is uncertain." | 7.69 | Angiotensin II-induced myocardial fibrosis in rats: role of nitric oxide, prostaglandins and bradykinin. ( Campbell, SE; Sigusch, HH; Weber, KT, 1996) |
| "Indomethacin caused microcytic anaemia, hypoalbuminaemia, small intestinal ulceration, caecal ulceration and inconspicuous raised mucosal lesions in the caecum that histologically showed submucosal fibrosis with disruption and thickening of the apical muscularis mucosae." | 5.07 | Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with indomethacin. ( Anthony, A; Dhillon, AP; Nygard, G; Pounder, RE; Sim, R; Wakefield, AJ, 1994) |
| "We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation." | 3.72 | Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003) |
| "There were significant fibrosis and inflammatory infiltration in the myocardium and blood vessels, represented by higher hydroxyproline and collagen volume fraction, and a large amount of inflammatory cells in the tissues of SAD rats." | 3.72 | Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. ( Chen, H; Shu, H; Su, DF; Xie, HH; Yuan, WJ; Zhang, C, 2003) |
| " Whether this perivascular and interstitial fibrosis is a direct effect of AngII on collagen turnover of these cells or an indirect response mediated by nitric oxide, prostaglandins and/or bradykinin released in response to AngII, is uncertain." | 3.69 | Angiotensin II-induced myocardial fibrosis in rats: role of nitric oxide, prostaglandins and bradykinin. ( Campbell, SE; Sigusch, HH; Weber, KT, 1996) |
| " The administration of antiinflammatory drugs resulted at some laser intensities in increased scores of maximum wound area, healing time, cumulated wound area, fibrosis, hydroxyproline, and hydroxylysine, being mostly pronounced for indomethacin at 0." | 3.68 | Laser induced wounds and scarring modified by antiinflammatory drugs: a murine model. ( Haedersdal, M; Poulsen, T; Wulf, HC, 1993) |
| "CSA hypertension was associated with renal perivascular fibrosis and divergent changes in immunohistochemical signals of renal arteriolar ETA (increases) and ETB (decreases) receptors." | 1.42 | Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling. ( Ali, RM; El-Gowelli, HM; El-Mas, MM; Helmy, MW, 2015) |
| "Increased bone resorption was present in LIF-treated hemicalvaria compared with that in the noninjected hemicalvaria or calvaria from mice injected with vehicle alone at both 6 and 13 days." | 1.29 | The effect of leukemia inhibitory factor on bone in vivo. ( Callon, K; Cornish, J; Edgar, S; King, A; Reid, IR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| El-Mas, MM | 1 |
| Helmy, MW | 1 |
| Ali, RM | 1 |
| El-Gowelli, HM | 1 |
| Amagase, K | 1 |
| Yokota, M | 1 |
| Tsukimi, Y | 1 |
| Okabe, S | 1 |
| Zhang, C | 1 |
| Chen, H | 1 |
| Xie, HH | 1 |
| Shu, H | 1 |
| Yuan, WJ | 1 |
| Su, DF | 1 |
| Saito, A | 1 |
| Okazaki, H | 1 |
| Sugawara, I | 1 |
| Yamamoto, K | 1 |
| Takizawa, H | 1 |
| Klopcic, B | 1 |
| Appelbee, A | 1 |
| Raye, W | 1 |
| Lloyd, F | 1 |
| Jooste, JC | 1 |
| Forrest, CH | 1 |
| Lawrance, IC | 1 |
| Anthony, A | 1 |
| Dhillon, AP | 1 |
| Sim, R | 1 |
| Nygard, G | 1 |
| Pounder, RE | 1 |
| Wakefield, AJ | 1 |
| Haedersdal, M | 1 |
| Poulsen, T | 1 |
| Wulf, HC | 1 |
| Cornish, J | 1 |
| Callon, K | 1 |
| King, A | 1 |
| Edgar, S | 1 |
| Reid, IR | 1 |
| Sigusch, HH | 1 |
| Campbell, SE | 1 |
| Weber, KT | 1 |
| Han, DS | 1 |
| Li, F | 1 |
| Holt, L | 1 |
| Connolly, K | 1 |
| Hubert, M | 1 |
| Miceli, R | 1 |
| Okoye, Z | 1 |
| Santiago, G | 1 |
| Windle, K | 1 |
| Wong, E | 1 |
| Sartor, RB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Dexmedetomidine on Levels of Plasma Inflammatory Factor in Asthma Patients Undergoing General Anesthesia-single Center,Randomized,Double-blind，Controlled Trial[NCT02289391] | Phase 4 | 80 participants (Anticipated) | Interventional | 2014-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for indomethacin and Cirrhosis
| Article | Year |
|---|---|
Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with indomethacin.
Topics: Administration, Oral; Anemia, Iron-Deficiency; Animals; Cecal Diseases; Cecum; Fibrosis; Indomethaci | 1994 |
9 other studies available for indomethacin and Cirrhosis
| Article | Year |
|---|---|
Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclosporine; Cytoprote | 2015 |
Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats.
Topics: Acetic Acid; Animals; Dinoprostone; Disease Models, Animal; Drug Administration Schedule; Fibrosis; | 2003 |
Inflammation is involved in the organ damage induced by sinoaortic denervation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aorta; Blood Vessels; Cardiomegaly; | 2003 |
Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro.
Topics: Actins; Cell Differentiation; Cell Division; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Di | 2003 |
Indomethacin and retinoic acid modify mouse intestinal inflammation and fibrosis: a role for SPARC.
Topics: Animals; Crohn Disease; Disease Models, Animal; Female; Fibrosis; Immunoenzyme Techniques; Indometha | 2008 |
Laser induced wounds and scarring modified by antiinflammatory drugs: a murine model.
Topics: Administration, Oral; Animals; Burns; Cicatrix; Dose-Response Relationship, Radiation; Female; Fibro | 1993 |
The effect of leukemia inhibitory factor on bone in vivo.
Topics: Animals; Bone and Bones; Bone Development; Bone Resorption; Fibrosis; Growth Inhibitors; Indomethaci | 1993 |
Angiotensin II-induced myocardial fibrosis in rats: role of nitric oxide, prostaglandins and bradykinin.
Topics: Angiotensin II; Animals; Arginine; Bradykinin; Bradykinin Receptor Antagonists; Collagen; Cyclooxyge | 1996 |
Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cell Division; Chroni | 2000 |