indomethacin has been researched along with Cirrhosis, Liver in 32 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic administration of misoprostol may have caused a negative natriuretic effect in cirrhotic patients with ascites." | 9.08 | The effects of chronic administration of indomethacin and misoprostol on renal function in cirrhotic patients with and without ascites. ( Hou, MC; Hsia, HC; Hwang, CC; Lee, FY; Lee, SD; Lin, HC; Tsai, YT, 1995) |
| "Nonsteroidal anti-inflammatory drugs (NSAID) suppress prostaglandin-dependent renal blood flow and furosemide-induced diuresis in patients with cirrhosis and ascites." | 9.05 | Sulindac and indomethacin suppress the diuretic action of furosemide in patients with cirrhosis and ascites: evidence that sulindac affects renal prostaglandins. ( Daskalopoulos, G; Gonzalez, M; Katkov, W; Kronborg, I; Laffi, G; Zipser, RD, 1985) |
| "Pretreatment with tocopheryl nicotinate and indomethacin increased the K values in the control subjects, but was without effect on the K values in patients with primary hepatoma." | 5.26 | Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma. ( Hobara, N; Watanabe, A, 1979) |
| "Chronic administration of misoprostol may have caused a negative natriuretic effect in cirrhotic patients with ascites." | 5.08 | The effects of chronic administration of indomethacin and misoprostol on renal function in cirrhotic patients with and without ascites. ( Hou, MC; Hsia, HC; Hwang, CC; Lee, FY; Lee, SD; Lin, HC; Tsai, YT, 1995) |
| "Nonsteroidal anti-inflammatory drugs (NSAID) suppress prostaglandin-dependent renal blood flow and furosemide-induced diuresis in patients with cirrhosis and ascites." | 5.05 | Sulindac and indomethacin suppress the diuretic action of furosemide in patients with cirrhosis and ascites: evidence that sulindac affects renal prostaglandins. ( Daskalopoulos, G; Gonzalez, M; Katkov, W; Kronborg, I; Laffi, G; Zipser, RD, 1985) |
| "To assess the effect of renal prostaglandins on the prognosis of liver cirrhosis, we studied the relationship between the effect of prostaglandin synthetase inhibition by indomethacin on glomerular filtration rate (GFR) and effective renal plasma flow (RPF) and survival in 30 patients with liver cirrhosis." | 3.67 | Effect of renal prostaglandins on survival in patients with liver cirrhosis. ( Hirayama, C; Kawasaki, H; Nosaka, Y; Suyama, A; Uemasu, J; Yamada, S, 1989) |
| "Aspirin may cause a transient shedding of renal tubular cells, alterations in urate excretion, inhibition of spironolactone action, and, in certain clinical settings, a reversible decline in renal function manifested as a fall in glomerular filtration that may be accompanied by mild water, sodium, and potassium retention." | 2.36 | Acute effects of aspirin and acetaminophen on renal function. ( Kimberly, RP; Plotz, PH, 1981) |
| "Reduced intrahepatic nitric oxide (NO) bioavailability and increased cyclooxygenase-1 (COX-1)-derived vasoconstrictor prostanoids modulate the hepatic vascular tone in cirrhosis." | 1.38 | Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats. ( Bosch, J; García-Pagán, JC; Gracia-Sancho, J; Monclús, M; Rodríguez-Vilarrupla, A; Rosado, E, 2012) |
| "Adenosine acts as an extracellular signaling molecule in various tissues and in liver this nucleoside exerts protective effects." | 1.35 | Activity and expression of ecto-5'-nucleotidase/CD73 are increased during phenotype conversion of a hepatic stellate cell line. ( Andrade, CM; Battastini, AM; Bernard, EA; Borojevic, R; Guaragna, RM; Guimarães, EL; Guma, FC; Jardim, FR; Margis, R; Roesch, GC; Souza, LF; Wink, MR, 2008) |
| "Indomethacin was both antidiuretic and antinatriuretic due principally to decreased free water clearance and increased proximal tubular reabsorption of sodium." | 1.29 | Indomethacin-induced renal dysfunction in patients with well-compensated cirrhosis. ( Dudley, F; Hsu, P; Massie, D; Wong, F, 1993) |
| "A patient had liver cirrhosis associated with marked hypoxemia." | 1.28 | Effects of indomethacin on hepatogenic pulmonary angiodysplasia. ( Okumura, M; Sakaguchi, S; Sasaki, H; Shijo, H; Yuh, K, 1991) |
| "Pretreatment with tocopheryl nicotinate and indomethacin increased the K values in the control subjects, but was without effect on the K values in patients with primary hepatoma." | 1.26 | Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma. ( Hobara, N; Watanabe, A, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (59.38) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosado, E | 1 |
| Rodríguez-Vilarrupla, A | 1 |
| Gracia-Sancho, J | 1 |
| Monclús, M | 1 |
| Bosch, J | 2 |
| García-Pagán, JC | 1 |
| Piva, A | 1 |
| Zampieri, F | 1 |
| Di Pascoli, M | 1 |
| Gatta, A | 1 |
| Sacerdoti, D | 1 |
| Bolognesi, M | 1 |
| Vaughan, RB | 1 |
| Angus, JA | 1 |
| Angus, PW | 1 |
| Andrade, CM | 1 |
| Roesch, GC | 1 |
| Wink, MR | 1 |
| Guimarães, EL | 1 |
| Souza, LF | 1 |
| Jardim, FR | 1 |
| Guaragna, RM | 1 |
| Bernard, EA | 1 |
| Margis, R | 1 |
| Borojevic, R | 1 |
| Battastini, AM | 1 |
| Guma, FC | 1 |
| Sakamoto, S | 2 |
| Koga, S | 2 |
| Ibayashi, H | 2 |
| Dunn, MJ | 1 |
| Holdstock, G | 1 |
| Chastenay, BF | 1 |
| Krawitt, EL | 1 |
| Soggia, G | 1 |
| Olmeo, NA | 1 |
| Satta, A | 1 |
| Faedda, R | 1 |
| Branca, GF | 1 |
| Anania, V | 1 |
| Desole, MS | 1 |
| Bartoli, E | 2 |
| Plotz, PH | 1 |
| Kimberly, RP | 1 |
| Chiandussi, L | 1 |
| Andrivet, P | 1 |
| Cadranel, J | 1 |
| Housset, B | 1 |
| Herigault, R | 1 |
| Harf, A | 1 |
| Adnot, S | 1 |
| Wong, F | 1 |
| Massie, D | 1 |
| Hsu, P | 1 |
| Dudley, F | 1 |
| Yin, J | 1 |
| Leng, X | 1 |
| Zhu, J | 1 |
| Hsia, HC | 1 |
| Lin, HC | 2 |
| Tsai, YT | 1 |
| Lee, FY | 2 |
| Hwang, CC | 1 |
| Hou, MC | 2 |
| Lee, SD | 2 |
| Barriere, E | 1 |
| Tazi, KA | 1 |
| Rona, JP | 1 |
| Pessione, F | 1 |
| Heller, J | 1 |
| Lebrec, D | 1 |
| Moreau, R | 1 |
| Criado, M | 1 |
| Flores, O | 1 |
| Vázquez, MJ | 1 |
| Esteller, A | 1 |
| Yang, YY | 1 |
| Huang, YT | 1 |
| Lee, TY | 1 |
| Lee, WC | 1 |
| Chang, FY | 1 |
| Hobara, N | 1 |
| Watanabe, A | 1 |
| Stokes, JB | 1 |
| Shijo, H | 2 |
| Sasaki, H | 2 |
| Miyajima, Y | 1 |
| Okumura, M | 2 |
| Yuh, K | 1 |
| Sakaguchi, S | 1 |
| Kristev, A | 1 |
| Mitkov, D | 1 |
| Lukanov, Y | 1 |
| Chapkynov, P | 1 |
| Kawasaki, H | 2 |
| Nosaka, Y | 1 |
| Yamada, S | 1 |
| Uemasu, J | 1 |
| Hirayama, C | 2 |
| Suyama, A | 1 |
| Yokota, M | 1 |
| Kakumu, S | 1 |
| Tahara, H | 1 |
| Fuji, A | 1 |
| Yoshioka, K | 1 |
| Seissiger, L | 1 |
| Dell, HD | 1 |
| Uemura, M | 1 |
| Tsujii, T | 1 |
| Fukui, H | 1 |
| Kita, K | 1 |
| Takaya, A | 1 |
| Tsukamoto, N | 1 |
| Nakayama, M | 1 |
| Matsumoto, M | 1 |
| Tamura, M | 1 |
| Murawaki, Y | 1 |
| Daskalopoulos, G | 1 |
| Kronborg, I | 1 |
| Katkov, W | 1 |
| Gonzalez, M | 1 |
| Laffi, G | 1 |
| Zipser, RD | 1 |
| Koopmans, PP | 1 |
| Bruix, J | 1 |
| Kravetz, D | 1 |
| Mastai, R | 1 |
| Rodés, J | 1 |
| Kapp, F | 1 |
| Baerlocher, C | 1 |
| Fahrländer, H | 1 |
2 reviews available for indomethacin and Cirrhosis, Liver
| Article | Year |
|---|---|
Acute effects of aspirin and acetaminophen on renal function.
Topics: Acetaminophen; Aspirin; Humans; Indomethacin; Kidney; Kidney Failure, Chronic; Liver Cirrhosis; Lupu | 1981 |
Pathophysiological and clinical aspects of the interaction between non-steroidal anti-inflammatory drugs (NSAID) and diuretics.
Topics: Anti-Inflammatory Agents; Diuretics; Drug Interactions; Drug Therapy, Combination; Heart Failure; Hu | 1985 |
2 trials available for indomethacin and Cirrhosis, Liver
| Article | Year |
|---|---|
The effects of chronic administration of indomethacin and misoprostol on renal function in cirrhotic patients with and without ascites.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Ascites; Drug Therapy, Combination; Female; Humans; I | 1995 |
Sulindac and indomethacin suppress the diuretic action of furosemide in patients with cirrhosis and ascites: evidence that sulindac affects renal prostaglandins.
Topics: Anti-Inflammatory Agents; Ascites; Clinical Trials as Topic; Creatinine; Dinoprostone; Diuresis; Dru | 1985 |
28 other studies available for indomethacin and Cirrhosis, Liver
| Article | Year |
|---|---|
Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats.
Topics: Animals; Arachidonic Acid; Biological Availability; Cyclooxygenase 1; Hepatocytes; Indomethacin; Liv | 2012 |
Mesenteric arteries responsiveness to acute variations of wall shear stress is impaired in rats with liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; | 2012 |
Vasoconstrictor responses are normal but prostanoid-mediated vasodilatation is enhanced in human cirrhotic mesenteric arteries.
Topics: Cardiovascular Agents; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques | 2005 |
Activity and expression of ecto-5'-nucleotidase/CD73 are increased during phenotype conversion of a hepatic stellate cell line.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Alkaline Phosphatase; Animals; Cell Line, Trans | 2008 |
Interleukin 1 activity in culture supernatant of lipopolysaccharide-stimulated monocytes from patients with chronic liver disease.
Topics: Adult; Aged; Cells, Cultured; Female; Hepatitis, Chronic; Humans; Indomethacin; Interleukin-1; Lipop | 1984 |
Role of eicosanoids in the control of renal function in severe hepatic disease.
Topics: Animals; Arachidonic Acids; Aspirin; Dogs; Humans; Ibuprofen; Indomethacin; Kidney; Lipoxygenase; Li | 1984 |
Studies on lymphocyte hyporesponsiveness in cirrhosis: the role of increased monocyte suppressor cell activity.
Topics: Adult; Aged; Hepatitis; Humans; Indomethacin; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Cir | 1982 |
The role of prostaglandins in Na retention of porta-cava shunted rats.
Topics: Animals; Female; Glomerular Filtration Rate; Indomethacin; Liver Cirrhosis; Male; Portacaval Shunt, | 1984 |
Prostaglandins and renal function in patients with ascites.
Topics: Ascites; Glomerular Filtration Rate; Humans; Indomethacin; Kidney; Liver Cirrhosis; Prostaglandins; | 1980 |
Mechanisms of impaired arterial oxygenation in patients with liver cirrhosis and severe respiratory insufficiency. Effects of indomethacin.
Topics: Aged; Arteries; Carbon Dioxide; Chronic Disease; Female; Hemodynamics; Humans; Indomethacin; Liver C | 1993 |
Indomethacin-induced renal dysfunction in patients with well-compensated cirrhosis.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Dinoprostone; Female; Glomerular Filtration Rate; Humans; | 1993 |
[Plasma prostacyclin (PGI2) levels in peripheral venous, arterial and portal venous blood in cirrhotic patients with portal hypertension and their clinical implication].
Topics: Adult; Aged; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Hypertension, Portal; Indometh | 1995 |
Evidence for an endothelium-derived hyperpolarizing factor in the superior mesenteric artery from rats with cirrhosis.
Topics: Acetylcholine; Animals; Apamin; Barium; Biological Factors; Charybdotoxin; Cyclooxygenase Inhibitors | 2000 |
Role of prostanoids and nitric oxide inhibition in rats with experimental hepatic fibrosis.
Topics: Animals; Blood Pressure; Body Weight; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Heart Ra | 2000 |
Adaptive vasodilatory response after octreotide treatment.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Blotting, Western; Cyclooxygenase Inhibitors; Dose-Res | 2001 |
Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Fluorouracil; Humans; Indomethacin; Kinetics; Liver Cirrhosis; Liver Neop | 1979 |
Liver disease and the renal prostaglandin system.
Topics: Glomerular Filtration Rate; Humans; Indomethacin; Kidney; Liver Cirrhosis; Liver Cirrhosis, Alcoholi | 1979 |
Prostaglandin F2 alpha and indomethacin in hepatogenic pulmonary angiodysplasia. Effects on pulmonary hemodynamics and gas exchange.
Topics: Aged; Dilatation, Pathologic; Dinoprost; Drug Therapy, Combination; Hemodynamics; Humans; Indomethac | 1991 |
Effects of indomethacin on hepatogenic pulmonary angiodysplasia.
Topics: Arteriovenous Fistula; Humans; Hypoxia; Indomethacin; Liver Cirrhosis; Lung; Lung Diseases; Male; Mi | 1991 |
The effect of octanoic fatty acid on the cardiovascular system of the guinea pig.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Caprylates; Cardiac Output; Cardiovascular Disease | 1989 |
Effect of renal prostaglandins on survival in patients with liver cirrhosis.
Topics: Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Indomethacin; Kidney; Liver Cirrhosis | 1989 |
Decreased interleukin 1 activity in culture supernatant of lipopolysaccharide stimulated monocytes from patients with liver cirrhosis and hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Body Temperature; C-Reactive Protein; Carcinoma, Hepatocellular; Din | 1987 |
Interleukin 1 alpha production by peripheral blood monocytes from patients with chronic liver disease and effect of sera on interleukin 1 alpha production.
Topics: Carrier State; Hepatitis B; Hepatitis, Chronic; Humans; In Vitro Techniques; Indomethacin; Interfero | 1988 |
[Acemetacin in patients with rheumatic disease with concomitant liver diseases. Pharmacokinetics, effectiveness and tolerance].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Inju | 1987 |
Urinary prostaglandins and renal function in chronic liver diseases.
Topics: Adult; Dinoprost; Dinoprostone; Female; Hemodynamics; Hepatitis; Hepatitis, Chronic; Humans; Indomet | 1986 |
Urinary kallikrein excretion in chronic liver disease and effect of indomethacin.
Topics: Aldosterone; Ascites; Bilirubin; Cholinesterases; Chronic Disease; Depression, Chemical; Humans; Ind | 1986 |
Effects of prostaglandin inhibition on systemic and hepatic hemodynamics in patients with cirrhosis of the liver.
Topics: Adult; Aged; Cardiac Output; Female; Hemodynamics; Humans; Indomethacin; Liver Circulation; Liver Ci | 1985 |
[Drugs and gastric hemorrhage. Results of 1 year's prospective study].
Topics: Alcoholic Beverages; Anticoagulants; Blood Transfusion; Cortisone; Drug Therapy, Combination; Gastro | 1974 |