indomethacin has been researched along with Cirrhoses, Experimental Liver in 13 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Angiotensin II dose-response studies were performed in conscious, chronically instrumented cirrhotic and control rats, and angiotensin II concentration-response studies were performed in isolated blood vessels obtained from similar groups of animals." | 2.67 | Dissociation between pressor sensitivity in vivo and contractile reactivity in vitro to angiotensin II in rats with experimental cirrhosis. ( Leehey, DJ, 1993) |
| "Indomethacin pretreatment almost completely abolished the responsiveness to sodium nitroprusside (NaNP) in cirrhotic rats, while not affecting controls." | 1.29 | Prostaglandins modulate the responsiveness of the gastric microcirculation of sodium nitroprusside in cirrhotic rats. ( Ferraz, P; Geraldo, J; Wallace, JL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Skiba, M | 1 |
| Maciejewska-Paszek, I | 1 |
| Pawłowska-Góral, K | 1 |
| Aleksiewicz, R | 1 |
| Wardas, M | 1 |
| Chan, CC | 2 |
| Wang, SS | 3 |
| Lee, FY | 3 |
| Chang, FY | 3 |
| Lin, HC | 3 |
| Hou, MC | 2 |
| Huang, HC | 3 |
| Lee, SD | 3 |
| Chang, CC | 2 |
| Tai, CC | 1 |
| Aller, MA | 1 |
| Arias, J | 1 |
| Lu, RH | 1 |
| Levy, M | 1 |
| Liszauer, A | 1 |
| Wexler, MJ | 1 |
| Beck, PL | 1 |
| McKnight, W | 1 |
| Lee, SS | 1 |
| Wallace, JL | 2 |
| Leehey, DJ | 2 |
| Geraldo, J | 1 |
| Ferraz, P | 1 |
| Denda, A | 1 |
| Endoh, T | 1 |
| Kitayama, W | 1 |
| Tang, Q | 1 |
| Noguchi, O | 1 |
| Kobayashi, Y | 1 |
| Akai, H | 1 |
| Okajima, E | 1 |
| Tsujiuchi, T | 1 |
| Tsutsumi, M | 1 |
| Nakae, D | 1 |
| Konishi, Y | 1 |
| Gupta, TK | 1 |
| Toruner, M | 1 |
| Chung, MK | 1 |
| Groszmann, RJ | 1 |
| Mourelle, M | 1 |
| Amezcua, JL | 1 |
| Pérez-Alvarez, V | 1 |
| Uckerman, MT | 1 |
| Rahman, MA | 1 |
1 trial available for indomethacin and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Dissociation between pressor sensitivity in vivo and contractile reactivity in vitro to angiotensin II in rats with experimental cirrhosis.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Dose-Response Relationship, Drug; In Vitro | 1993 |
12 other studies available for indomethacin and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Hepatoprotective action of PGE1 analogue estimated by measuring the concentrations of acetoacetate and beta-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Disease; Administration, Oral; Alanine Transaminase; Ani | 2003 |
Effects of endothelin-1 on portal-systemic collaterals of common bile duct-ligated cirrhotic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Collateral Circulation; C | 2004 |
Effects of norepinephrine and acetylcholine on portal-systemic collaterals of common bile duct-ligated cirrhotic rat.
Topics: Acetylcholine; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertens | 2005 |
Portal systemic collateral development: is it a trophic adaptation mechanism to hepatic deprivation?
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Collateral | 2006 |
Chronic indomethacin treatment enhances the portal-systemic collateral vascular response to vasopressin in bile-duct ligated rats.
Topics: Animals; Arginine Vasopressin; Bile Ducts; Blood Pressure; Collateral Circulation; Dose-Response Rel | 2007 |
Renal blood flow in normal dogs and in dogs with experimental liver cirrhosis following the acute continuous infusion of endotoxin.
Topics: Animals; Bile Acids and Salts; Blood Pressure; Body Temperature; Dogs; Endotoxins; Female; Indometha | 1983 |
Prostaglandin modulation of the gastric vasculature and mucosal integrity in cirrhotic rats.
Topics: Animals; Blood Flow Velocity; Blood Vessels; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Li | 1993 |
Prostaglandins modulate the responsiveness of the gastric microcirculation of sodium nitroprusside in cirrhotic rats.
Topics: Analysis of Variance; Animals; Arginine; Aspirin; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Indo | 1996 |
Inhibition by piroxicam of oxidative DNA damage, liver cirrhosis and development of enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Choline; | 1997 |
Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats.
Topics: Acetylcholine; Animals; Calcimycin; Carbon Tetrachloride Poisoning; Endothelium, Vascular; Indometha | 1998 |
Reduction of apparent indicators of liver cirrhosis in rats by the arachidonate lipoxygenase inhibitor BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alanine Transaminase; Alkaline Phospha | 1987 |
Role of prostaglandins and thromboxane in the control of renal hemodynamics in experimental liver cirrhosis.
Topics: Animals; Glomerular Filtration Rate; Hemodynamics; Imidazoles; Indomethacin; Kidney; Liver Cirrhosis | 1989 |