indomethacin has been researched along with Cholera in 14 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Cholera: An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera." | 9.05 | Indomethacin and chloroquine fail to inhibit fluid loss in cholera. ( Butler, T; Rabbani, GH, 1985) |
| "The effects of indomethacin on intestine mucosal cAMP, intestinal fluid secretion, and mucosal and fluid PGE were studied in rabbits in vivo following challenge with cholera toxin." | 7.65 | Effects of indomethacin on intestinal secretion, prostaglandin E and cyclic AMP: evidence against a role for prostaglandins in cholera toxin-induced secretion. ( El-Hindi, E; Poppe, L; Tao, P; Wilson, DE, 1975) |
| "Human cholera is associated with an increased luminal release of prostaglandin E2 (PGE2), but whether inhibition of increased PGE2 synthesis will reduce or control intestinal secretion is uncertain." | 5.28 | Indomethacin decreases jejunal fluid secretion in addition to luminal release of prostaglandin E2 in patients with acute cholera. ( Bukhave, K; Rabbani, GH; Rask-Madsen, J; Van Loon, FP, 1992) |
| "A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera." | 5.05 | Indomethacin and chloroquine fail to inhibit fluid loss in cholera. ( Butler, T; Rabbani, GH, 1985) |
| "The effects of indomethacin on intestine mucosal cAMP, intestinal fluid secretion, and mucosal and fluid PGE were studied in rabbits in vivo following challenge with cholera toxin." | 3.65 | Effects of indomethacin on intestinal secretion, prostaglandin E and cyclic AMP: evidence against a role for prostaglandins in cholera toxin-induced secretion. ( El-Hindi, E; Poppe, L; Tao, P; Wilson, DE, 1975) |
| "Human cholera is associated with an increased luminal release of prostaglandin E2 (PGE2), but whether inhibition of increased PGE2 synthesis will reduce or control intestinal secretion is uncertain." | 1.28 | Indomethacin decreases jejunal fluid secretion in addition to luminal release of prostaglandin E2 in patients with acute cholera. ( Bukhave, K; Rabbani, GH; Rask-Madsen, J; Van Loon, FP, 1992) |
| "Indomethacin treatment of animals challenged with Salmonella resulted in less fluid accumulation, in addition to lower concentrations of intestinal cAMP and prostaglandins, compared to that of similarly changed loops in normal animals." | 1.27 | Enterotoxin-induced fluid accumulation during experimental salmonellosis and cholera: involvement of prostaglandin synthesis by intestinal cells. ( Duebbert, IE; Peterson, JW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (85.71) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bennett, A | 2 |
| Charlier, EM | 1 |
| Mathias, JR | 1 |
| Carlson, GM | 1 |
| Nalin, DR | 1 |
| Wilson, DE | 1 |
| El-Hindi, E | 1 |
| Tao, P | 1 |
| Poppe, L | 1 |
| Bedwani, JR | 1 |
| Okpako, DT | 1 |
| Bukhave, K | 2 |
| Van Loon, FP | 1 |
| Rabbani, GH | 2 |
| Rask-Madsen, J | 1 |
| Duebbert, IE | 1 |
| Peterson, JW | 1 |
| Butler, T | 1 |
| Kimberg, DV | 1 |
| Field, M | 1 |
| Gershon, E | 1 |
| Henderson, A | 1 |
| Jacoby, HI | 1 |
| Marshall, CH | 1 |
| Gots, RE | 1 |
| Formal, SB | 1 |
| Giannella, RA | 1 |
| Lexomboon, U | 1 |
| Goth, A | 1 |
| Finkelstein, RA | 1 |
1 review available for indomethacin and Cholera
| Article | Year |
|---|---|
Prostaglandin E2 in intestinal secretion with special reference to methodological problems in vivo and in vitro.
Topics: Adenoma; Animals; Cholera; Colonic Diseases, Functional; Diarrhea; Dinoprostone; Dose-Response Relat | 1992 |
1 trial available for indomethacin and Cholera
| Article | Year |
|---|---|
Indomethacin and chloroquine fail to inhibit fluid loss in cholera.
Topics: Adult; Body Weight; Chloroquine; Cholera; Clinical Trials as Topic; Diarrhea; Female; Fluid Therapy; | 1985 |
12 other studies available for indomethacin and Cholera
| Article | Year |
|---|---|
Evidence against the release of prostaglandin-like material from isolated intestinal tissue by pure cholera toxin.
Topics: Animals; Bromides; Cholera; Dihydroergotoxine; Ethanolamines; Female; Guinea Pigs; Humans; Ileum; In | 1977 |
Indomethacin in cholera diarrhoea.
Topics: Animals; Cholera; Dogs; Drug Evaluation; Humans; Indomethacin; Salicylates | 1976 |
Testing for cholera antagonists.
Topics: Adult; Animals; Antitoxins; Cholera; Diarrhea; Dogs; Drug Evaluation, Preclinical; Humans; Indometha | 1977 |
Effects of indomethacin on intestinal secretion, prostaglandin E and cyclic AMP: evidence against a role for prostaglandins in cholera toxin-induced secretion.
Topics: Animals; Cholera; Cyclic AMP; Drug Interactions; Female; Indomethacin; Injections, Intramuscular; In | 1975 |
The relationship of prostaglandins to cholera.
Topics: Animals; Cats; Cholera; Cyclic AMP; Guinea Pigs; Humans; Indomethacin; Intestinal Mucosa; Prostaglan | 1976 |
Effects of crude and pure cholera toxin on prostaglandin.
Topics: Animals; Cholera; Enterotoxins; Female; Ileum; Indomethacin; Male; Prostaglandins; Rabbits; Stimulat | 1975 |
Indomethacin decreases jejunal fluid secretion in addition to luminal release of prostaglandin E2 in patients with acute cholera.
Topics: Adult; Cholera; Dinoprostone; Humans; Indomethacin; Intestinal Secretions; Jejunum; Male; Secretory | 1992 |
Enterotoxin-induced fluid accumulation during experimental salmonellosis and cholera: involvement of prostaglandin synthesis by intestinal cells.
Topics: Animals; Body Fluids; Cholera; Cholera Toxin; Cricetinae; Cricetulus; Cyclic AMP; Enterotoxins; Fema | 1985 |
Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.
Topics: Adenylyl Cyclases; Animals; Aspirin; Cholera; Cyclic AMP; Drug Synergism; Enterotoxins; Enzyme Activ | 1974 |
Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Body Fluids; Body Weight; Cholera; | 1972 |
Indomethacin inhibition of Salmonella typhimurium, Shigella flexneri, and cholera-mediated rabbit ileal secretion.
Topics: Animals; Cholera; Ileum; Indomethacin; Prostaglandins; Rabbits; Salmonella Infections, Animal; Salmo | 1974 |
Applications of the mouse foot edema test in evaluation of anti-cholera drugs.
Topics: Animals; Anti-Infective Agents; Aspirin; Chloramphenicol; Cholera; Cycloheximide; Dactinomycin; Diur | 1971 |