indomethacin has been researched along with Child Development Deviations in 9 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soraisham, AS | 1 |
| Sauve, R | 1 |
| Singhal, N | 1 |
| Schmidt, B | 2 |
| Seshia, M | 1 |
| Shankaran, S | 2 |
| Mildenhall, L | 1 |
| Tyson, J | 1 |
| Lui, K | 1 |
| Fok, T | 1 |
| Roberts, R | 1 |
| Wadhawan, R | 1 |
| Oh, W | 1 |
| Vohr, BR | 2 |
| Saha, S | 1 |
| Das, A | 1 |
| Bell, EF | 1 |
| Laptook, A | 1 |
| Stoll, BJ | 1 |
| Walsh, MC | 1 |
| Higgins, R | 1 |
| Wickremasinghe, AC | 1 |
| Rogers, EE | 1 |
| Piecuch, RE | 1 |
| Johnson, BC | 1 |
| Golden, S | 1 |
| Moon-Grady, AJ | 1 |
| Clyman, RI | 1 |
| Ment, LR | 2 |
| Vohr, B | 1 |
| Allan, W | 1 |
| Katz, KH | 2 |
| Schneider, KC | 2 |
| Westerveld, M | 2 |
| Duncan, CC | 1 |
| Makuch, RW | 2 |
| Allan, WC | 1 |
| Hasan, SU | 1 |
| Ohlsson, A | 1 |
| Roberts, RS | 1 |
| Davis, P | 1 |
| Moddeman, D | 1 |
| Saigal, S | 1 |
| Solimano, A | 1 |
| Vincer, M | 1 |
| Wright, L | 1 |
| Hansen, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)[NCT00009646] | Phase 3 | 1,202 participants (Actual) | Interventional | 1993-11-30 | Completed | ||
| Randomized Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial[NCT00033917] | Phase 3 | 630 participants (Actual) | Interventional | 1989-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cranial ultrasounds were performed daily for the first 5 postnatal days; the main outcome measure was intraaventricular hemorrhage (IVH) at 5 days of age (NCT00033917)
Timeframe: at 5 days
| Intervention | IVH (Number) |
|---|---|
| Indomethacin | 25 |
| Placebo | 40 |
"Peabody Picture Vocabulary Test (PPVT) This is a semantic language test. The mean value is 100; standard deviation is 16 points. A higher score means better language; a lower score means poorer language.~There are no subscales to the PPVT. The measurement unit is points on a scale. A score < 70 indicates severely abnormal language function." (NCT00033917)
Timeframe: at 8 years
| Intervention | participants with PPVT score < 70 (Number) |
|---|---|
| Indomethacin - no IVH | 12 |
| Indomethacin - IVH | 5 |
| Placebo - no IVH | 24 |
| Placebo - IVH | 7 |
1 review available for indomethacin and Child Development Deviations
| Article | Year |
|---|---|
Bartter's syndrome.
Topics: Bartter Syndrome; Blood Cell Count; Cyclooxygenase Inhibitors; Developmental Disabilities; Diagnosis | 2006 |
2 trials available for indomethacin and Child Development Deviations
| Article | Year |
|---|---|
Effects of prophylactic indomethacin in extremely low-birth-weight infants with and without adequate exposure to antenatal corticosteroids.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Developmental Disabilities; Female | 2011 |
School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial.
Topics: Cerebral Hemorrhage; Cerebral Palsy; Cerebral Ventricles; Child; Cohort Studies; Developmental Disab | 2003 |
6 other studies available for indomethacin and Child Development Deviations
| Article | Year |
|---|---|
Indomethacin tocolysis and neurodevelopmental outcome.
Topics: Adult; Child, Preschool; Cohort Studies; Developmental Disabilities; Female; Humans; Indomethacin; M | 2011 |
Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Developmental Disabilities; Ductus Arteriosus, Paten | 2013 |
Neurodevelopmental outcomes following two different treatment approaches (early ligation and selective ligation) for patent ductus arteriosus.
Topics: Age Factors; Blindness; Cardiovascular Agents; Cerebral Palsy; Child, Preschool; Combined Modality T | 2012 |
Change in cognitive function over time in very low-birth-weight infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Damage, Chronic; Cerebral Hemorrhage; Child; Child, P | 2003 |
Inhaled nitric oxide.
Topics: Administration, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Bronchopulmonary Dysplasia; Dev | 2005 |
Male/female differences in indomethacin effects in preterm infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebral Ventricles; Developmental Disabilities; Female; Hu | 2005 |