indomethacin has been researched along with Chemical and Drug Induced Liver Injury in 66 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures." | 7.81 | Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015) |
| " The cytoprotective effect of central TRH on CCl(4)-induced acute hepatocellular necrosis was abolished by hepatic branch vagotomy, atropine, indomethacin and N(G)-nitro-L-arginine methyl ester, but not by 6-hydroxydopamine." | 7.72 | Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats. ( Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M, 2003) |
| "We present an infrequent case of acute hepatitis by indomethacin, in a patient with a primary biliary cirrhosis, previously not diagnosed and asymptomatic, in who during in the follow-up, with a persistent analytical pattern of disociated cholestasis, a liver biopsy was indicated, with the final diagnosis of chronic non-suppurative destructive cholangitis." | 7.69 | [Acute ++indomethacin-induced hepatitis in a female patient with asymptomatic primary biliary cirrhosis]. ( Alvarez Navascues, C; González González, M; González Sotorrio, N; Rodrigo Sáez, L; Rodríguez García, M; Suárez González, A, 1994) |
| "Thymol is a monoterpene phenol with many different pharmacological activities." | 5.48 | Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model. ( Aysin, F; Cerig, S; Erol, HS; Geyikoglu, F; Koc, K; Ozek, NS; Yilmaz, EG, 2018) |
| "Indomethacin is a well tolerated non-steroidal inflammatory drug (NSAID) widely used in the treatment of pericarditis but it can provoke acute renal failure." | 5.40 | Irreversible acute renal failure and cholestatic hepatitis following therapy with indomethacin in an HIV-naive patient with pericarditis: a case report. ( Bonura, S; Colomba, C; Madonia, S; Rubino, R; Siracusa, L, 2014) |
| " In this study, NS-398, a specific COX-2 inhibitor, and indomethacin, a COX-1 and COX-2 inhibitor, were administered 24 h after chloroform dosing to determine their effect on liver injury in Sprague-Dawley rats." | 5.32 | Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. ( Begay, CK; Gandolfi, AJ, 2003) |
| "This study investigated the gastroprotective effects of N-acetylcysteine (NAC) against indomethacin-induced gastric ulcer in rats." | 3.85 | N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms. ( Ali, DA; Katary, MA; Soliman, NA; Zineldeen, DH, 2017) |
| "A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures." | 3.81 | Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015) |
| " The cytoprotective effect of central TRH on CCl(4)-induced acute hepatocellular necrosis was abolished by hepatic branch vagotomy, atropine, indomethacin and N(G)-nitro-L-arginine methyl ester, but not by 6-hydroxydopamine." | 3.72 | Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats. ( Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M, 2003) |
| "We present an infrequent case of acute hepatitis by indomethacin, in a patient with a primary biliary cirrhosis, previously not diagnosed and asymptomatic, in who during in the follow-up, with a persistent analytical pattern of disociated cholestasis, a liver biopsy was indicated, with the final diagnosis of chronic non-suppurative destructive cholangitis." | 3.69 | [Acute ++indomethacin-induced hepatitis in a female patient with asymptomatic primary biliary cirrhosis]. ( Alvarez Navascues, C; González González, M; González Sotorrio, N; Rodrigo Sáez, L; Rodríguez García, M; Suárez González, A, 1994) |
| "Thymol is a monoterpene phenol with many different pharmacological activities." | 1.48 | Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model. ( Aysin, F; Cerig, S; Erol, HS; Geyikoglu, F; Koc, K; Ozek, NS; Yilmaz, EG, 2018) |
| "Indomethacin is a well tolerated non-steroidal inflammatory drug (NSAID) widely used in the treatment of pericarditis but it can provoke acute renal failure." | 1.40 | Irreversible acute renal failure and cholestatic hepatitis following therapy with indomethacin in an HIV-naive patient with pericarditis: a case report. ( Bonura, S; Colomba, C; Madonia, S; Rubino, R; Siracusa, L, 2014) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " In this study, NS-398, a specific COX-2 inhibitor, and indomethacin, a COX-1 and COX-2 inhibitor, were administered 24 h after chloroform dosing to determine their effect on liver injury in Sprague-Dawley rats." | 1.32 | Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. ( Begay, CK; Gandolfi, AJ, 2003) |
| "Gastric ulcers were induced by abdominal injection of 0." | 1.31 | [Synthesis, preliminary antigastrelcosis activity and the protective effect on acute liver injury of zinc chlorin E4]. ( Liu, JF; Lu, JG; Wang, XY; Yao, JZ; Zhang, WN; Zhou, YJ; Zhu, J, 2001) |
| " The plasma levels of IM after the oral administration of IM-OE and IM-BE were comparatively low compared with those after IM, with a small bioavailability (2." | 1.29 | Pharmacokinetics of indomethacin ester prodrugs: gastrointestinal and hepatic toxicity and the hydrolytic capacity of various tissues in rats. ( Iwaki, M; Muraoka, O; Nagai, T; Ogiso, T; Tanabe, G; Tanino, T; Ueda, Y, 1996) |
| "The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase." | 1.28 | Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis? ( Ben-Zvi, Z; Danon, A; Katz, S; Weissman-Teitellman, B, 1990) |
| "A case of systemic lupus erythematosus (SLE) with mononucleosis-like hepatic injury was described." | 1.28 | Drug-induced mononucleosis-like hepatic injury in a patient with systemic lupus erythematosus. ( Fujita, S; Kumagai, T; Nakanuma, Y; Okuda, K; Takegoshi, K; Tohyama, T, 1989) |
| " In therapeutic dosage it will adequately control joint symptoms in the majority of patients." | 1.26 | Pharmacotherapy of juvenile rheumatoid arthritis. ( Lindsley, CB, 1981) |
| "Pretreatment with pregnenolone-16a-carbonitrile (PCN) protects the rat against the toxic effects of indomethacin, digitoxin, cyclophosphamide and many other injurious agents." | 1.25 | Ultrastructural changes in hepatocytes induced by pregnenolone-16a-carbonitrile (PCN). ( Dobardzic, R, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (50.00) | 18.7374 |
| 1990's | 9 (13.64) | 18.2507 |
| 2000's | 8 (12.12) | 29.6817 |
| 2010's | 16 (24.24) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vasilevsky, SF | 1 |
| Govdi, AI | 1 |
| Shults, EE | 1 |
| Shakirov, MM | 1 |
| Sorokina, IV | 1 |
| Tolstikova, TG | 1 |
| Baev, DS | 1 |
| Tolstikov, GA | 1 |
| Alabugin, IV | 1 |
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Geyikoglu, F | 1 |
| Yilmaz, EG | 1 |
| Erol, HS | 1 |
| Koc, K | 1 |
| Cerig, S | 1 |
| Ozek, NS | 1 |
| Aysin, F | 1 |
| Colomba, C | 1 |
| Siracusa, L | 1 |
| Madonia, S | 1 |
| Bonura, S | 1 |
| Rubino, R | 1 |
| Lu, W | 1 |
| Cheng, F | 1 |
| Jiang, J | 1 |
| Zhang, C | 1 |
| Deng, X | 1 |
| Xu, Z | 1 |
| Zou, S | 1 |
| Shen, X | 1 |
| Tang, Y | 1 |
| Huang, J | 1 |
| Jones, MC | 1 |
| Lasak-Myall, T | 1 |
| Abdelhak, TM | 1 |
| Varelas, PN | 1 |
| Soliman, NA | 1 |
| Zineldeen, DH | 1 |
| Katary, MA | 1 |
| Ali, DA | 1 |
| Bhattacharyya, S | 1 |
| Banerjee, S | 1 |
| Guha, C | 1 |
| Ghosh, S | 1 |
| Sil, PC | 1 |
| Begay, CK | 1 |
| Gandolfi, AJ | 1 |
| Yao, JZ | 1 |
| Liu, JF | 1 |
| Zhang, WN | 1 |
| Zhou, YJ | 1 |
| Zhu, J | 1 |
| Lu, JG | 1 |
| Wang, XY | 1 |
| Sato, Y | 1 |
| Yoneda, M | 2 |
| Nakamura, K | 2 |
| Makino, I | 2 |
| Terano, A | 1 |
| LaFramboise, WA | 1 |
| Bombach, KL | 1 |
| Pogozelski, AR | 1 |
| Cullen, RF | 1 |
| Muha, N | 1 |
| Lyons-Weiler, J | 1 |
| Spear, SJ | 1 |
| Dhir, RJ | 1 |
| Guthrie, RD | 1 |
| Magovern, JA | 1 |
| Dial, EJ | 1 |
| Darling, RL | 1 |
| Lichtenberger, LM | 1 |
| Fenech, FF | 1 |
| Bannister, WH | 1 |
| Grech, JL | 1 |
| Kelsey, WM | 1 |
| Scharyj, M | 1 |
| Korneĭchuk, AV | 1 |
| Kushnir, LV | 1 |
| Iwaoka, T | 1 |
| Umeda, T | 1 |
| Nakayama, M | 1 |
| Shimada, T | 1 |
| Fujii, Y | 1 |
| Miura, F | 1 |
| Sato, T | 1 |
| Lindsley, CB | 1 |
| de Kraker-Sangster, M | 1 |
| Bronkhorst, FB | 1 |
| Brandt, KH | 1 |
| Boersma, JW | 1 |
| Borbás, B | 1 |
| Kiss, E | 1 |
| Varga, M | 1 |
| Suárez González, A | 1 |
| Rodríguez García, M | 1 |
| González González, M | 1 |
| Alvarez Navascues, C | 1 |
| González Sotorrio, N | 1 |
| Rodrigo Sáez, L | 1 |
| Barriault, C | 1 |
| Audet, M | 1 |
| Yousef, IM | 1 |
| Tuchweber, B | 1 |
| Manoukian, AV | 1 |
| Carson, JL | 1 |
| Ogiso, T | 1 |
| Iwaki, M | 1 |
| Tanino, T | 1 |
| Nagai, T | 1 |
| Ueda, Y | 1 |
| Muraoka, O | 1 |
| Tanabe, G | 1 |
| Pawlowska-Góral, K | 1 |
| Wardas, M | 1 |
| Maciejewska-Paszek, I | 1 |
| Skiba, M | 1 |
| Nogaj, S | 1 |
| Ito, T | 1 |
| Takamoto, S | 1 |
| Nakade, Y | 1 |
| Okamoto, S | 1 |
| Okada, M | 1 |
| Yokohama, S | 1 |
| Aso, K | 1 |
| Tolot, F | 2 |
| Prost, G | 2 |
| Guignot, B | 2 |
| Pelletier, M | 2 |
| Watanabe, S | 1 |
| Okuyama, H | 1 |
| Kawada, N | 1 |
| Mizoguchi, Y | 2 |
| Kobayashi, K | 2 |
| Yamamoto, S | 2 |
| Morisawa, S | 1 |
| Shen, J | 3 |
| Zhang, XJ | 2 |
| Nie, SQ | 1 |
| Wang, CC | 3 |
| Cong, Z | 1 |
| Ben-Zvi, Z | 1 |
| Weissman-Teitellman, B | 1 |
| Katz, S | 1 |
| Danon, A | 1 |
| Fried, W | 1 |
| Nagai, H | 1 |
| Aoki, M | 1 |
| Shimazawa, T | 1 |
| Yakuo, I | 1 |
| Koda, A | 1 |
| Kasahara, M | 1 |
| Wallace, DJ | 1 |
| Metzger, AL | 1 |
| Klinenberg, JR | 1 |
| Takegoshi, K | 1 |
| Tohyama, T | 1 |
| Okuda, K | 1 |
| Kumagai, T | 1 |
| Fujita, S | 1 |
| Nakanuma, Y | 1 |
| Koyama, Y | 1 |
| Imoto, M | 1 |
| Tanaka, M | 1 |
| Fukuda, Y | 1 |
| Satake, T | 1 |
| Ozawa, T | 1 |
| Schlegel, SI | 1 |
| Paulus, HE | 1 |
| Victorino, RM | 1 |
| Maria, VA | 1 |
| Tajima, S | 1 |
| Nishimura, N | 1 |
| Ito, K | 1 |
| Chang, X | 1 |
| Balduck, N | 1 |
| Otten, J | 1 |
| Verbruggen, L | 1 |
| Bougatef, A | 1 |
| Ramet, J | 1 |
| Piepsz, A | 1 |
| Seissiger, L | 1 |
| Dell, HD | 1 |
| Olmos, M | 1 |
| Guma, C | 1 |
| Colombato, LO | 1 |
| Lami, G | 1 |
| Miyashiro, R | 1 |
| Alvarez, E | 1 |
| Miyajima, K | 1 |
| Kitamura, M | 1 |
| Tsutsui, H | 1 |
| Takeda, H | 1 |
| Shin, T | 1 |
| Sakagami, Y | 1 |
| Seki, S | 1 |
| López Navidad, A | 1 |
| Cadafalch Arpa, J | 1 |
| Vehi Gasol, C | 1 |
| Espinos Pérez, J | 1 |
| Ivlev, AS | 1 |
| Polunina, TE | 1 |
| Wendel, A | 1 |
| Tiegs, G | 1 |
| O'Brien, WM | 1 |
| Bagby, GF | 1 |
| Glants, RM | 1 |
| Dobardzic, R | 1 |
| Sun, DC | 1 |
| Opolon, P | 1 |
| Cartron, J | 1 |
| Chicot, D | 1 |
| Caroli, J | 1 |
| Cuthbert, MF | 1 |
| Henrard, JC | 1 |
| Prokopová, D | 1 |
6 reviews available for indomethacin and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induced Liver Injur | 1996 |
[Multiple manifestations of intolerance in association with anti-inflammatory agents. Role of phenylbutazone].
Topics: Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug Tolera | 1976 |
Regulation of extrarenal erythropoietin production.
Topics: Angiotensin II; Animals; Atmospheric Pressure; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1989 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen | 1986 |
Rare adverse reactions to nonsteroidal antiinflammatory drugs (3).
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver Injury; | 1985 |
1 trial available for indomethacin and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
NSAID usage patterns by rheumatologists in the treatment of SLE.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Clinical Trials as | 1989 |
59 other studies available for indomethacin and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Efficient synthesis of the first betulonic acid-acetylene hybrids and their hepatoprotective and anti-inflammatory activity.
Topics: Acetylene; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Edema; Enzymes | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liv | 2018 |
Irreversible acute renal failure and cholestatic hepatitis following therapy with indomethacin in an HIV-naive patient with pericarditis: a case report.
Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; An | 2014 |
FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Genetic Predisposit | 2015 |
Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injur | 2015 |
N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; A | 2017 |
A 35 kDa Phyllanthus niruri protein suppresses indomethacin mediated hepatic impairments: Its role in Hsp70, HO-1, JNKs and Ca
Topics: Animals; Calcium; Chemical and Drug Induced Liver Injury; Heme Oxygenase-1; Hepatitis; Hepatocytes; | 2017 |
Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Cyclooxygenase In | 2003 |
[Synthesis, preliminary antigastrelcosis activity and the protective effect on acute liver injury of zinc chlorin E4].
Topics: Animals; Anti-Ulcer Agents; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 2001 |
Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Carbon Tetrachloride; Che | 2003 |
Hepatic gene expression response to acute indomethacin exposure.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome | 2006 |
Importance of biliary excretion of indomethacin in gastrointestinal and hepatic injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract; Chemical and Drug Induced Liver Inj | 2008 |
Hepatitis with biliverdinaemia in association with indomethacin therapy.
Topics: Bile Pigments; Bilirubin; Chemical and Drug Induced Liver Injury; Humans; Indomethacin; Liver Functi | 1967 |
Fatal hepatitis probably due to indomethacin.
Topics: Anemia; Chemical and Drug Induced Liver Injury; Child; Humans; Indomethacin; Male | 1967 |
[Case of drug (krizanol) hepatitis].
Topics: Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dimercaprol; Drug Therapy, Com | 1982 |
A case of membranous nephropathy associated with thyroid antigens.
Topics: Antigens; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Hypothyroidism; I | 1982 |
Pharmacotherapy of juvenile rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; | 1981 |
[Massive liver cell necrosis following administration of indomethacin in combination with aminophenzone].
Topics: Adult; Aminopyrine; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Hepatic Encep | 1981 |
[2 cases of acute liver damage caused by indomethacin].
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Huma | 1980 |
[Acute ++indomethacin-induced hepatitis in a female patient with asymptomatic primary biliary cirrhosis].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Female; Humans; Indomethacin; Liver Cirrhosis | 1994 |
Protection by indomethacin against the lethality and hepatotoxicity of phalloidin in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspirin; Chemical and Drug Induced Liver | 1994 |
Pharmacokinetics of indomethacin ester prodrugs: gastrointestinal and hepatic toxicity and the hydrolytic capacity of various tissues in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Li | 1996 |
The usefulness of antioxidative enzymes for the estimation of synthetic effects of PGE1 analogue.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Combinatio | 2001 |
Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antit | 2002 |
[Multiple manifestations of intolerance of a combination of anti-inflammatory drugs. Role of phenylbutazone].
Topics: Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver Injury; Duodenal Ulcer; Erythema; | 1975 |
Effect of dietary alpha-linolenate/linoleate balance on endotoxin-induced hepatitis in mice.
Topics: alpha-Linolenic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Chemical and Drug Induced Liver | 1991 |
Arachidonic acid metabolites in carbon tetrachloride-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzoquinones; Carbon Tetrachloride Pois | 1990 |
[Effects of indomethacin on 45Ca uptake and membrane fluidity of mitochondria and microsomes from rat liver].
Topics: Animals; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Indomethacin; Male; | 1990 |
[Observing cytoprotection of indomethacin on primary cultured hepatocytes of rats].
Topics: Animals; Carbon Tetrachloride Poisoning; Cells, Cultured; Chemical and Drug Induced Liver Injury; In | 1990 |
Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?
Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Glutathione; Hexobarbital; | 1990 |
Effect of OKY-046 and ONO-3708 on liver injury in mice.
Topics: Acrylates; Animals; Chemical and Drug Induced Liver Injury; Epoprostenol; Indomethacin; Liver; Liver | 1989 |
Drug-induced mononucleosis-like hepatic injury in a patient with systemic lupus erythematosus.
Topics: Adult; Cefoxitin; Cephalosporins; Chemical and Drug Induced Liver Injury; Dibekacin; Female; Humans; | 1989 |
Changes in endogenous prostaglandin levels during D-galactosamine-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Galactosamine | 1989 |
Modifications of the lymphocyte transformation test in a case of drug-induced cholestatic hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Erythromycin; Erythromycin Ethylsuccinat | 1985 |
Suppression of delayed-type hypersensitivity mediated by macrophage-like cells in mice with experimental liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver I | 1985 |
[Hepatic protection of indomethacin against carbon tetrachloride toxicity in rats].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 1988 |
Sudden death of a child with juvenile chronic arthritis, probably due to indomethacin.
Topics: Adolescent; Arthritis; Chemical and Drug Induced Liver Injury; Death, Sudden; Humans; Indomethacin; | 1987 |
[Acemetacin in patients with rheumatic disease with concomitant liver diseases. Pharmacokinetics, effectiveness and tolerance].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Inju | 1987 |
[Hepatic lesions induced by drugs. Report of 26 cases].
Topics: Adult; Aged; Biopsy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis, Intr | 1987 |
[Augmentation of drug-induced lymphocyte transformation by indomethacin in patients with drug-induced allergic hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Guinea Pigs; Humans; Indomet | 1987 |
[Acute hepatitis caused by indomethacin].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Humans; Indomethacin; Male; Middle Aged | 1987 |
[Drug-induced lesion of the liver].
Topics: Adult; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; | 1987 |
A novel biologically active seleno-organic compound--VI. Protection by ebselen (PZ 51) against galactosamine/endotoxin-induced hepatitis in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azoles; Chemical and Drug Induced Liver | 1986 |
[Prostaglandins in transfusion science (experimental research)].
Topics: Acute Kidney Injury; Amino Acids; Animals; Blood Transfusion; Chemical and Drug Induced Liver Injury | 1985 |
Ultrastructural changes in hepatocytes induced by pregnenolone-16a-carbonitrile (PCN).
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Digitoxin; Drug Synergism; Endopl | 1972 |
Iatrogenic gastrointestinal diseases in the aged.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aged; Cathartics; Chemical and Drug Induced Li | 1972 |
[Application of the lymphoblastic transformation test (LTT) to the diagnosis of drug-induced hepatitis].
Topics: Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; | 1969 |
Adverse reactions to non-steroidal antirheumatic drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Chemical and Drug Induced Liv | 1974 |
[Current analgesic anti-inflammatory drugs].
Topics: Analgesics; Aniline Compounds; Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver In | 1970 |
[Effect of various antirheumatics on the biosynthesis of collagen].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroquine; Collagen; Indomethacin; Male; Mice; Ra | 1968 |