indomethacin has been researched along with Central Nervous System Diseases in 16 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind, double-dummy, crossover study was carried out in 8 centres to compare the efficacy and tolerability of 'controlled-release' ketoprofen tablets (200 mg) with that of indomethacin suppositories (100 mg) in out-patients with definite or classical rheumatoid arthritis." | 9.07 | A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening. ( Leden, I; Rubin, B; Uddenfeldt, P, 1993) |
| "A double-blind, double-dummy, crossover study was carried out in 8 centres to compare the efficacy and tolerability of 'controlled-release' ketoprofen tablets (200 mg) with that of indomethacin suppositories (100 mg) in out-patients with definite or classical rheumatoid arthritis." | 5.07 | A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening. ( Leden, I; Rubin, B; Uddenfeldt, P, 1993) |
| "In patients with orthostatic hypotension and central nervous system involvement indomethacin increased recumbent blood pressure, resting forearm vascular resistance, and reflex forearm vasoconstriction during lower body negative pressure." | 1.27 | Increase in reflex vasoconstriction with indomethacin in patients with orthostatic hypotension and central nervous system involvement. ( Ashihara, T; Imaizumi, T; Nakamura, M; Shibazaki, H; Takeshita, A; Tsuji, S, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (87.50) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Imaizumi, T | 1 |
| Takeshita, A | 1 |
| Ashihara, T | 1 |
| Nakamura, M | 1 |
| Tsuji, S | 1 |
| Shibazaki, H | 1 |
| Taylor, WJ | 1 |
| Alpert, BS | 1 |
| Roberts, MC | 1 |
| Uddenfeldt, P | 1 |
| Leden, I | 1 |
| Rubin, B | 1 |
| Allan, R | 1 |
| Bleicher, M | 1 |
| Bright, TP | 1 |
| McNulty, CJ | 1 |
| Schlegel, SI | 1 |
| Paulus, HE | 1 |
| Inman, WH | 1 |
| Heere, LP | 1 |
| Lehtinen, K | 1 |
| Kaarela, K | 1 |
| Ahonen, M | 1 |
| Forsberg, S | 1 |
| Luukkainen, R | 1 |
| Martio, J | 1 |
| Mutru, O | 1 |
| Nykänen, E | 1 |
| Nykänen, P | 1 |
| Pesonen, J | 1 |
| Gordin, A | 1 |
| Sotka, S | 1 |
| Nuutila, J | 1 |
| Kinsella, TD | 1 |
| MacKenzie, KR | 1 |
| Kim, SO | 1 |
| Johnson, LG | 1 |
| Bröll, H | 1 |
| Eberl, R | 1 |
| Sochor, H | 1 |
| Tausch, G | 1 |
| Rothermich, NO | 1 |
| Måseide, T | 1 |
1 review available for indomethacin and Central Nervous System Diseases
| Article | Year |
|---|---|
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen | 1986 |
6 trials available for indomethacin and Central Nervous System Diseases
| Article | Year |
|---|---|
A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening.
Topics: Administration, Rectal; Adult; Aged; Ambulatory Care; Arthritis, Rheumatoid; Central Nervous System | 1993 |
Biarison in the treatment of degenerative joint diseases: comparison with indomethacin and placebo.
Topics: Adult; Aged; Anti-Inflammatory Agents; Central Nervous System Diseases; Double-Blind Method; Drug To | 1977 |
Piroxicam in acute musculoskeletal disorders and sport injuries.
Topics: Acute Disease; Adult; Athletic Injuries; Central Nervous System Diseases; Clinical Trials as Topic; | 1987 |
A six-month follow-up study of a slow-release indomethacin tablet in rheumatic diseases.
Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Diseases; Clinical Trials as Topic; Delayed-A | 1987 |
Comparison of a slow-release indomethacin tablet and naproxen in osteoarthrosis.
Topics: Adult; Aged; Central Nervous System Diseases; Clinical Trials as Topic; Delayed-Action Preparations; | 1985 |
Evaluation of indomethacin by a controlled, cross-over technique in 30 patients with ankylosing spondylitis.
Topics: Alkaline Phosphatase; Anemia, Hypochromic; Aspartate Aminotransferases; Aspirin; Central Nervous Sys | 1967 |
9 other studies available for indomethacin and Central Nervous System Diseases
| Article | Year |
|---|---|
Increase in reflex vasoconstriction with indomethacin in patients with orthostatic hypotension and central nervous system involvement.
Topics: Adult; Aged; Central Nervous System Diseases; Forearm; Hemodynamics; Humans; Hypotension, Orthostati | 1984 |
Prostaglandins and the management of congenital heart disease.
Topics: Age Factors; Alprostadil; Cardiovascular Diseases; Central Nervous System Diseases; Ductus Arteriosu | 1982 |
Adverse effects of indomethacin in the horse.
Topics: Animals; Ataxia; Central Nervous System Diseases; Dose-Response Relationship, Drug; Horse Diseases; | 1982 |
Suspected central nervous system toxicity from inadvertent nonsteroidal antiinflammatory drug overdose.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Diseases; Diclofenac; Drug Overdose; | 1991 |
Non-steroidal anti-inflammatory drugs: assessment of risks.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Central Nervous Syste | 1987 |
[Tolerance of long-term indomethacin treatment].
Topics: Adult; Aged; Arthritis, Rheumatoid; Central Nervous System Diseases; Chronic Disease; Drug Tolerance | 1972 |
An extended study of indomethacin. I. Clinical pharmacology.
Topics: Adult; Aged; Arthritis; Central Nervous System Diseases; Fibromyalgia; Gastrointestinal Diseases; He | 1966 |
[Use of antiphlogistics for athletic injuries].
Topics: Analgesics; Athletic Injuries; Central Nervous System Diseases; Humans; Indomethacin; Male; Oxyphenb | 1969 |
A nonsteroidal anti-inflammatory agent. Indomethacin (indocin).
Topics: Arthritis, Rheumatoid; Central Nervous System Diseases; Gastrointestinal Diseases; Humans; Indometha | 1966 |