indomethacin has been researched along with Cell Transformation, Viral in 15 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Cell Transformation, Viral: An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this report we describe results showing that both arachidonic acid (20:4) release and prostaglandin (PG) synthesis in herpes simplex virus type 2 (HSV-2)-transformed tumor-derived rat fibrosarcoma (RFS) cells are inhibited by indomethacin (cyclooxygenase inhibitor)." | 3.67 | Studies of phospholipase and cyclooxygenase activities in herpes simplex virus type 2-transformed rat cells. ( Heitman, CR; Kucera, LS; Waite, M, 1989) |
| "Treatment with glutaraldehyde, instead of mitomycin, greatly weakened the suppressive activity of the MD lymphoblastoid cells." | 1.28 | Suppression mediated in vitro by Marek's disease virus-transformed T-lymphoblastoid cell lines: effect on lymphoproliferation. ( Quere, P, 1992) |
| "Indomethacin treatment (1 microgram/ml) of the RA auto-MLR led to increased production of supernatant inhibitory activity (8% +/- 4 without, 57% +/- 4 with indomethacin), but had no significant effect on the inhibition of EBV-induced B cell proliferation by normal auto-MLR supernatants." | 1.27 | Analysis of the defects responsible for the impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E. ( Bluestein, HG; Epstein, LB; Hasler, F; Zvaifler, NJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (86.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Evans, PM | 2 |
| Van de Griend, RJ | 1 |
| Van Krimpen, BA | 1 |
| Bol, SJ | 1 |
| Thompson, A | 1 |
| Bolhuis, RL | 1 |
| Claesson, HE | 2 |
| Lindgren, JA | 2 |
| Hammarström, S | 2 |
| Tanaka, Y | 1 |
| Sugamura, K | 1 |
| Hinuma, Y | 1 |
| Hasler, F | 1 |
| Bluestein, HG | 1 |
| Zvaifler, NJ | 1 |
| Epstein, LB | 1 |
| Bruserud, O | 1 |
| Moen, T | 1 |
| Zhang, X | 1 |
| Morham, SG | 1 |
| Langenbach, R | 1 |
| Young, DA | 1 |
| Quere, P | 1 |
| Heitman, CR | 1 |
| Waite, M | 1 |
| Kucera, LS | 1 |
| Deichman, GI | 1 |
| Kashleva, HA | 1 |
| Kluchareva, TE | 1 |
| Matveeva, VA | 1 |
| Mukherjee, PK | 1 |
| Simpson, RW | 1 |
| Lanham, DF | 1 |
| Lin, MC | 1 |
| Segawa, K | 1 |
| Ito, Y | 1 |
| Beckner, SK | 1 |
| Froelich, CJ | 1 |
| Guiffaut, S | 1 |
15 other studies available for indomethacin and Cell Transformation, Viral
| Article | Year |
|---|---|
Platelet-facilitated adhesion of SV40-3T3 cells to collagen.
Topics: Adult; Animals; Aspirin; Blood Platelets; Cell Adhesion; Cell Transformation, Viral; Collagen; Human | 1984 |
Rapid expansion of human cytotoxic T cell clones: growth promotion by a heat-labile serum component and by various types of feeder cells.
Topics: B-Lymphocytes; Cell Communication; Cell Division; Cell Line; Cell Transformation, Viral; Clone Cells | 1984 |
Endogenous prostaglandin E2 production inhibits proliferation of polyoma virus-transformed 3T3 cells: correlation with cellular levels of cyclic AMP.
Topics: Animals; Cell Division; Cell Transformation, Viral; Cells, Cultured; Cyclic AMP; DNA; Indomethacin; | 1980 |
T cell growth factor from human splenic cell cultures: conditions for its production, and its utilization for maintenance of cytotoxic T cell lines.
Topics: Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cytotoxicity, | 1981 |
Analysis of the defects responsible for the impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E.
Topics: Arthritis, Rheumatoid; B-Lymphocytes; Cell Adhesion; Cell Transformation, Viral; Herpesvirus 4, Huma | 1983 |
Production of interleukin 2 containing growth medium for cloning of human T lymphocytes.
Topics: B-Lymphocytes; Cell Adhesion; Cell Transformation, Viral; Clone Cells; Culture Media; Herpesvirus 4, | 1984 |
Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Cell Line | 1999 |
Endogenous prostaglandin E2 synthesis inhibits growth of polyoma virus-transformed 3T3 fibroblasts.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Viral; Cyclic AMP; DNA, Neoplasm; Indomethac | 1979 |
Suppression mediated in vitro by Marek's disease virus-transformed T-lymphoblastoid cell lines: effect on lymphoproliferation.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cell Transformation, Viral; Chickens; Glutaral; Herpesvi | 1992 |
Studies of phospholipase and cyclooxygenase activities in herpes simplex virus type 2-transformed rat cells.
Topics: Animals; Cell Line; Cell Transformation, Viral; Cycloheximide; Enzyme Induction; Fibrosarcoma; Herpe | 1989 |
Clustering of discrete cell properties essential for tumorigenicity and metastasis. II. Studies of Syrian hamster embryo fibroblasts transformed by Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Carmustine; Cell Transformation, Viral; Cells, Cultured; Cricetinae; | 1989 |
Indomethacin inhibits viral RNA and protein synthesis in cells infected with vesicular stomatitis virus.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Transformation, Viral; Humans; Indomethacin; Laryngeal Neo | 1985 |
Effects of inhibitors of arachidonic acid metabolism on intercellular adhesion of SV40-3T3 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Cell Aggregation; Cell Transformat | 1986 |
The effect of viral transformation on prostaglandin production depends on cell type.
Topics: Animals; Antigens, Viral, Tumor; Avian Sarcoma Viruses; Cell Cycle; Cell Differentiation; Cell Line; | 1986 |
Induction of lymphokine activated killer cells in serum-free medium.
Topics: Cell Line; Cell Transformation, Viral; Culture Media; Cytotoxicity, Immunologic; Humans; Indomethaci | 1986 |