indomethacin has been researched along with Cell Transformation, Neoplastic in 34 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this rat model of gastrointestinal reflux, indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma." | 3.78 | Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ( Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2012) |
| "We studied LSCs in mouse models of acute myelogenous leukemia (AML) induced either by coexpression of the Hoxa9 and Meis1a oncogenes or by the fusion oncoprotein MLL-AF9." | 1.36 | The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. ( Armstrong, SA; Feng, Z; Goessling, W; Krivtsov, AV; North, TE; Sinha, AU; Wang, Y; Zon, LI, 2010) |
| " We demonstrate that a reduction of cyclooxygenase 2 gene dosage rescued the ovarian aging phenotype of the Wv mice, whereas homozygous deletion was accompanied by a compensatory increase in ovarian cyclooxygenase 1 expression and prostaglandin E(2) synthesis." | 1.34 | A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. ( Cai, KQ; Hamilton, TC; Klein-Szanto, A; Smedberg, JL; Smith, ER; Xu, XX; Yang, WL, 2007) |
| "Indomethacin treatment significantly reduced the levels of TxB2 and 6-keto-PGF1 alpha to < 10% of those present in untreated or irradiated cells." | 1.29 | Effect of modifiers of arachidonic acid metabolism on radiation transformation and eicosanoid formation in C3H/10T1/2 cells. ( Billings, PC; Kennedy, AR; Maki, PA, 1994) |
| "Carprofen was shown to reduce PGE2 levels to a similar or greater extent than indomethacin at each level of linoleate in the diet." | 1.28 | A comparison of the effects of the prostaglandin synthesis inhibitors indomethacin and carprofen on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats fed different amounts of essential fatty acid. ( Carter, CA; Ip, C; Ip, MM, 1989) |
| "Indomethacin has been reported to suppress the growth of colonic tumors induced in rats by various carcinogenic drugs." | 1.27 | Effect of indomethacin on the growth of colon cancer cells in syngeneic rats. ( Caignard, A; Martin, F; Martin, MS; Olsson, NO, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (55.88) | 18.7374 |
| 1990's | 9 (26.47) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Krivtsov, AV | 1 |
| Sinha, AU | 1 |
| North, TE | 1 |
| Goessling, W | 1 |
| Feng, Z | 1 |
| Zon, LI | 1 |
| Armstrong, SA | 1 |
| Esquivias, P | 1 |
| Morandeira, A | 1 |
| Escartín, A | 1 |
| Cebrián, C | 1 |
| Santander, S | 1 |
| Esteva, F | 1 |
| García-González, MA | 1 |
| Ortego, J | 1 |
| Lanas, A | 1 |
| Piazuelo, E | 1 |
| Chen, XZ | 1 |
| Zhang, JY | 1 |
| Zeng, JY | 1 |
| Yang, R | 1 |
| Liu, F | 1 |
| Zhao, J | 1 |
| Zhang, WB | 1 |
| Wang, YX | 1 |
| Mao, AH | 1 |
| Tang, WR | 1 |
| Liao, SQ | 1 |
| Miura, D | 1 |
| Kobayashi, M | 1 |
| Kakiuchi, S | 1 |
| Kasahara, Y | 1 |
| Kondo, S | 1 |
| Yang, WL | 1 |
| Cai, KQ | 1 |
| Smedberg, JL | 1 |
| Smith, ER | 1 |
| Klein-Szanto, A | 1 |
| Hamilton, TC | 1 |
| Xu, XX | 1 |
| Milman, HA | 1 |
| Goodwin, JS | 1 |
| Ceuppens, J | 1 |
| Tanaka, Y | 1 |
| Sugamura, K | 1 |
| Hinuma, Y | 1 |
| Skubitz, KM | 1 |
| Zhen, YS | 1 |
| August, JT | 1 |
| Greiner, JW | 1 |
| Evans, CH | 1 |
| Hagiwara, M | 1 |
| McNamara, DB | 1 |
| Chen, IL | 1 |
| Fisher, JW | 1 |
| Olsson, NO | 1 |
| Caignard, A | 1 |
| Martin, MS | 1 |
| Martin, F | 1 |
| Takenaga, K | 1 |
| Hozumi, M | 1 |
| Boyd, JA | 1 |
| Barrett, JC | 1 |
| Eling, TE | 1 |
| McCarthy, ME | 1 |
| Zwilling, BS | 1 |
| Favalli, C | 1 |
| Garaci, E | 1 |
| Etheredge, E | 1 |
| Santoro, MG | 1 |
| Jaffe, BM | 1 |
| Carty, TJ | 1 |
| Eskra, JD | 1 |
| Lombardino, JG | 1 |
| Hoffman, WW | 1 |
| Taffet, SM | 1 |
| Russell, SW | 1 |
| Lu, X | 1 |
| Xie, W | 1 |
| Reed, D | 1 |
| Bradshaw, WS | 1 |
| Simmons, DL | 1 |
| Billings, PC | 1 |
| Maki, PA | 1 |
| Kennedy, AR | 1 |
| Bennett, SA | 1 |
| Birnboim, HC | 1 |
| Lavnikova, N | 1 |
| Lakhotia, A | 1 |
| Patel, N | 1 |
| Prokhorova, S | 1 |
| Laskin, DL | 1 |
| Dong, Z | 1 |
| Huang, C | 1 |
| Brown, RE | 1 |
| Ma, WY | 1 |
| Glasgow, WC | 1 |
| Everhart, AL | 1 |
| Zhang, X | 1 |
| Morham, SG | 1 |
| Langenbach, R | 1 |
| Young, DA | 1 |
| Claesson, HE | 1 |
| Lindgren, JA | 1 |
| Hammarström, S | 2 |
| Polsky-Cynkin, R | 1 |
| Hong, S | 1 |
| Levine, L | 1 |
| Hsiao, WL | 1 |
| Pai, HL | 1 |
| Matsui, MS | 1 |
| Weinstein, IB | 1 |
| Hietanen, E | 1 |
| Bartsch, H | 1 |
| Bereziat, JC | 1 |
| Ahotupa, M | 1 |
| Camus, AM | 1 |
| Cabral, JR | 1 |
| Laitinen, M | 1 |
| Carter, CA | 1 |
| Ip, MM | 1 |
| Ip, C | 1 |
| Sakiyama, H | 1 |
| Yasukawa, M | 1 |
| Terasima, T | 1 |
| Kanegasaki, S | 1 |
| Voiculescu, C | 1 |
| Rogoz, S | 1 |
| Rosu, L | 1 |
| Nagasawa, H | 1 |
| Naito, T | 1 |
2 reviews available for indomethacin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Possible contribution of indomethacin to the carcinogenicity of nongenotoxic bladder carcinogens that cause bladder calculi.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclooxygenase Inhibitors; | 2007 |
Regulation of the immune response by prostaglandins.
Topics: Adult; Aged; Animals; Antibody Formation; Autoantibodies; Cattle; Cell Transformation, Neoplastic; C | 1983 |
32 other studies available for indomethacin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.
Topics: Animals; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Genes, Homeobox; Granulo | 2010 |
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic | 2012 |
[Differentiation of rat bone marrow mesenchymal stem cells into adipocytes and blockage of the differentiation].
Topics: Adipocytes; Animals; Bone Marrow Cells; Cell Differentiation; Cell Transformation, Neoplastic; Cells | 2012 |
Enhancement of transformed foci and induction of prostaglandins in Balb/c 3T3 cells by palytoxin: in vitro model reproduces carcinogenic responses in animal models regarding the inhibitory effect of indomethacin and reversal of indomethacin's effect by ex
Topics: Acrylamides; Animals; BALB 3T3 Cells; Carcinogens; Cell Transformation, Neoplastic; Cnidarian Venoms | 2006 |
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.
Topics: Adenoma; Aging; Animals; Blotting, Western; Celecoxib; Cell Transformation, Neoplastic; Cyclooxygena | 2007 |
T cell growth factor from human splenic cell cultures: conditions for its production, and its utilization for maintenance of cytotoxic T cell lines.
Topics: Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cytotoxicity, | 1981 |
Dexamethasone synergistically induces chemotactic peptide receptor expression in HL-60 cells.
Topics: Cell Line; Cell Transformation, Neoplastic; Dexamethasone; Dimethyl Sulfoxide; Dimethylformamide; Do | 1982 |
Temporal dynamics of cortisol and dexamethasone prevention of benzo(a)pyrene-induced morphological transformation of Syrian hamster cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured | 1982 |
Role of endogenous prostaglandin E2 in erythropoietin production and dome formation by human renal carcinoma cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinoma; Cell Transformation, Neoplastic; Cells, Cul | 1984 |
Effect of indomethacin on the growth of colon cancer cells in syngeneic rats.
Topics: Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Colonic Neoplasms; Dinoprostone; | 1984 |
[Cellular actions of inhibitors of chemical carcinogenesis: modifications of syntheses of prostaglandins and differentiation of myeloid leukemia cells].
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Dexamethasone; Humans; Indomethacin; Leukem | 1983 |
Prostaglandin endoperoxide synthetase-dependent cooxidation of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in C3H/10T 1/2 clone 8 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzopyrenes; Cell Line; Cell Transformation, Neoplast | 1982 |
Differential effects of prostaglandins on the antitumor activity of normal and BCG-activated macrophages.
Topics: Animals; Cell Transformation, Neoplastic; Cytotoxicity, Immunologic; Indomethacin; Macrophages; Male | 1981 |
Influence of PGE on the immune response in melanoma-bearing mice.
Topics: Agglutinins; Animals; Antibody-Producing Cells; Cell Transformation, Neoplastic; Female; Hypersensit | 1980 |
Piroxicam, a potent inhibitor of prostaglandin production in cell culture. Structure-activity study.
Topics: Animals; Anti-Inflammatory Agents; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; In | 1980 |
Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cytotoxicity, Immunologic; Indomethacin; | 1981 |
Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Avian Sarcoma Viruses; Base Sequence; C | 1995 |
Effect of modifiers of arachidonic acid metabolism on radiation transformation and eicosanoid formation in C3H/10T1/2 cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic | 1994 |
Platelet activating factor induces transformation of human fibroblasts.
Topics: Alkaloids; Analysis of Variance; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Fi | 1995 |
Cytostasis is required for IL-1 induced nitric oxide production in transformed hamster fibroblasts.
Topics: Animals; Arginine; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Cyto | 1996 |
Inhibition of activator protein 1 activity and neoplastic transformation by aspirin.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aspirin; Calcium-Calmodulin-Depende | 1997 |
The role of linoleic acid metabolism in the proliferative response of cells overexpressing the erbB-2/HER2 oncogene.
Topics: Animals; Arachidonic Acid; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; C | 1997 |
Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Cell Line | 1999 |
Prostaglandin E2 production in 3T3 cells transformed by polyoma virus raises the intracellular adenosine 3':5'-monophosphate levels.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Aspirin; Cell Line; Cell Transformation, Neoplastic; Cyclic AMP; In | 1977 |
Prostaglandin production by normal and transformed 3T3 fibroblasts in cell culture.
Topics: Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic; Culture Media; Indomethacin; Kinetics | 1977 |
The effects of hydroquinone, hematin and heme-containing proteins on prostaglandin biosynthesis by methylcholanthrene-transformed mouse BALB/3T3 fibroblasts.
Topics: Animals; Arachidonic Acids; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Glutathio | 1976 |
Effects of specific fatty acids on cell transformation induced by an activated c-H-ras oncogene.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic; Gene Expre | 1990 |
Quantity and saturation degree of dietary fats as modulators of oxidative stress and chemically-induced liver tumours in rats.
Topics: Animals; Biomarkers; Blood Chemical Analysis; Cell Transformation, Neoplastic; Cholesterol; Dietary | 1990 |
A comparison of the effects of the prostaglandin synthesis inhibitors indomethacin and carprofen on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats fed different amounts of essential fatty acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cell | 1989 |
Inhibition of X-ray or chemical carcinogen-induced neoplastic transformation of C3H10T1/2 fibroblasts by lipopolysaccharides.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Transformation, Neoplastic; Cells, Cultured; Fibr | 1986 |
Spleen natural killer cell activity in mice implanted with allogeneic fibroblast-like tumour cells following in vivo exposure to beta-interferon, interleukin-1 or indomethacin.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Indomethacin; Interferon Type I; Interleukin-1; | 1987 |
Inhibition by indomethacin of spontaneous mammary tumorigenesis in SHN mice.
Topics: Animals; Body Weight; Cell Transformation, Neoplastic; Estrus; Female; Indomethacin; Mammary Neoplas | 1986 |