Page last updated: 2024-10-29

indomethacin and Cell Transformation, Neoplastic

indomethacin has been researched along with Cell Transformation, Neoplastic in 34 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Research Excerpts

ExcerptRelevanceReference
"In this rat model of gastrointestinal reflux, indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma."3.78Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ( Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2012)
"We studied LSCs in mouse models of acute myelogenous leukemia (AML) induced either by coexpression of the Hoxa9 and Meis1a oncogenes or by the fusion oncoprotein MLL-AF9."1.36The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. ( Armstrong, SA; Feng, Z; Goessling, W; Krivtsov, AV; North, TE; Sinha, AU; Wang, Y; Zon, LI, 2010)
" We demonstrate that a reduction of cyclooxygenase 2 gene dosage rescued the ovarian aging phenotype of the Wv mice, whereas homozygous deletion was accompanied by a compensatory increase in ovarian cyclooxygenase 1 expression and prostaglandin E(2) synthesis."1.34A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. ( Cai, KQ; Hamilton, TC; Klein-Szanto, A; Smedberg, JL; Smith, ER; Xu, XX; Yang, WL, 2007)
"Indomethacin treatment significantly reduced the levels of TxB2 and 6-keto-PGF1 alpha to < 10% of those present in untreated or irradiated cells."1.29Effect of modifiers of arachidonic acid metabolism on radiation transformation and eicosanoid formation in C3H/10T1/2 cells. ( Billings, PC; Kennedy, AR; Maki, PA, 1994)
"Carprofen was shown to reduce PGE2 levels to a similar or greater extent than indomethacin at each level of linoleate in the diet."1.28A comparison of the effects of the prostaglandin synthesis inhibitors indomethacin and carprofen on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats fed different amounts of essential fatty acid. ( Carter, CA; Ip, C; Ip, MM, 1989)
"Indomethacin has been reported to suppress the growth of colonic tumors induced in rats by various carcinogenic drugs."1.27Effect of indomethacin on the growth of colon cancer cells in syngeneic rats. ( Caignard, A; Martin, F; Martin, MS; Olsson, NO, 1984)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199019 (55.88)18.7374
1990's9 (26.47)18.2507
2000's3 (8.82)29.6817
2010's3 (8.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, Y1
Krivtsov, AV1
Sinha, AU1
North, TE1
Goessling, W1
Feng, Z1
Zon, LI1
Armstrong, SA1
Esquivias, P1
Morandeira, A1
Escartín, A1
Cebrián, C1
Santander, S1
Esteva, F1
García-González, MA1
Ortego, J1
Lanas, A1
Piazuelo, E1
Chen, XZ1
Zhang, JY1
Zeng, JY1
Yang, R1
Liu, F1
Zhao, J1
Zhang, WB1
Wang, YX1
Mao, AH1
Tang, WR1
Liao, SQ1
Miura, D1
Kobayashi, M1
Kakiuchi, S1
Kasahara, Y1
Kondo, S1
Yang, WL1
Cai, KQ1
Smedberg, JL1
Smith, ER1
Klein-Szanto, A1
Hamilton, TC1
Xu, XX1
Milman, HA1
Goodwin, JS1
Ceuppens, J1
Tanaka, Y1
Sugamura, K1
Hinuma, Y1
Skubitz, KM1
Zhen, YS1
August, JT1
Greiner, JW1
Evans, CH1
Hagiwara, M1
McNamara, DB1
Chen, IL1
Fisher, JW1
Olsson, NO1
Caignard, A1
Martin, MS1
Martin, F1
Takenaga, K1
Hozumi, M1
Boyd, JA1
Barrett, JC1
Eling, TE1
McCarthy, ME1
Zwilling, BS1
Favalli, C1
Garaci, E1
Etheredge, E1
Santoro, MG1
Jaffe, BM1
Carty, TJ1
Eskra, JD1
Lombardino, JG1
Hoffman, WW1
Taffet, SM1
Russell, SW1
Lu, X1
Xie, W1
Reed, D1
Bradshaw, WS1
Simmons, DL1
Billings, PC1
Maki, PA1
Kennedy, AR1
Bennett, SA1
Birnboim, HC1
Lavnikova, N1
Lakhotia, A1
Patel, N1
Prokhorova, S1
Laskin, DL1
Dong, Z1
Huang, C1
Brown, RE1
Ma, WY1
Glasgow, WC1
Everhart, AL1
Zhang, X1
Morham, SG1
Langenbach, R1
Young, DA1
Claesson, HE1
Lindgren, JA1
Hammarström, S2
Polsky-Cynkin, R1
Hong, S1
Levine, L1
Hsiao, WL1
Pai, HL1
Matsui, MS1
Weinstein, IB1
Hietanen, E1
Bartsch, H1
Bereziat, JC1
Ahotupa, M1
Camus, AM1
Cabral, JR1
Laitinen, M1
Carter, CA1
Ip, MM1
Ip, C1
Sakiyama, H1
Yasukawa, M1
Terasima, T1
Kanegasaki, S1
Voiculescu, C1
Rogoz, S1
Rosu, L1
Nagasawa, H1
Naito, T1

Reviews

2 reviews available for indomethacin and Cell Transformation, Neoplastic

ArticleYear
Possible contribution of indomethacin to the carcinogenicity of nongenotoxic bladder carcinogens that cause bladder calculi.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:3

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclooxygenase Inhibitors;

2007
Regulation of the immune response by prostaglandins.
    Journal of clinical immunology, 1983, Volume: 3, Issue:4

    Topics: Adult; Aged; Animals; Antibody Formation; Autoantibodies; Cattle; Cell Transformation, Neoplastic; C

1983

Other Studies

32 other studies available for indomethacin and Cell Transformation, Neoplastic

ArticleYear
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.
    Science (New York, N.Y.), 2010, Mar-26, Volume: 327, Issue:5973

    Topics: Animals; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Genes, Homeobox; Granulo

2010
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
    World journal of gastroenterology, 2012, Sep-21, Volume: 18, Issue:35

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic

2012
[Differentiation of rat bone marrow mesenchymal stem cells into adipocytes and blockage of the differentiation].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2012, Volume: 34, Issue:11

    Topics: Adipocytes; Animals; Bone Marrow Cells; Cell Differentiation; Cell Transformation, Neoplastic; Cells

2012
Enhancement of transformed foci and induction of prostaglandins in Balb/c 3T3 cells by palytoxin: in vitro model reproduces carcinogenic responses in animal models regarding the inhibitory effect of indomethacin and reversal of indomethacin's effect by ex
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 89, Issue:1

    Topics: Acrylamides; Animals; BALB 3T3 Cells; Carcinogens; Cell Transformation, Neoplastic; Cnidarian Venoms

2006
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.
    The American journal of pathology, 2007, Volume: 170, Issue:4

    Topics: Adenoma; Aging; Animals; Blotting, Western; Celecoxib; Cell Transformation, Neoplastic; Cyclooxygena

2007
T cell growth factor from human splenic cell cultures: conditions for its production, and its utilization for maintenance of cytotoxic T cell lines.
    Microbiology and immunology, 1981, Volume: 25, Issue:10

    Topics: Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cytotoxicity,

1981
Dexamethasone synergistically induces chemotactic peptide receptor expression in HL-60 cells.
    Blood, 1982, Volume: 59, Issue:3

    Topics: Cell Line; Cell Transformation, Neoplastic; Dexamethasone; Dimethyl Sulfoxide; Dimethylformamide; Do

1982
Temporal dynamics of cortisol and dexamethasone prevention of benzo(a)pyrene-induced morphological transformation of Syrian hamster cells.
    Cancer research, 1982, Volume: 42, Issue:10

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured

1982
Role of endogenous prostaglandin E2 in erythropoietin production and dome formation by human renal carcinoma cells in culture.
    The Journal of clinical investigation, 1984, Volume: 74, Issue:4

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinoma; Cell Transformation, Neoplastic; Cells, Cul

1984
Effect of indomethacin on the growth of colon cancer cells in syngeneic rats.
    International journal of immunopharmacology, 1984, Volume: 6, Issue:4

    Topics: Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Colonic Neoplasms; Dinoprostone;

1984
[Cellular actions of inhibitors of chemical carcinogenesis: modifications of syntheses of prostaglandins and differentiation of myeloid leukemia cells].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:9

    Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Dexamethasone; Humans; Indomethacin; Leukem

1983
Prostaglandin endoperoxide synthetase-dependent cooxidation of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in C3H/10T 1/2 clone 8 cells.
    Cancer research, 1982, Volume: 42, Issue:7

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzopyrenes; Cell Line; Cell Transformation, Neoplast

1982
Differential effects of prostaglandins on the antitumor activity of normal and BCG-activated macrophages.
    Cellular immunology, 1981, May-01, Volume: 60, Issue:1

    Topics: Animals; Cell Transformation, Neoplastic; Cytotoxicity, Immunologic; Indomethacin; Macrophages; Male

1981
Influence of PGE on the immune response in melanoma-bearing mice.
    Journal of immunology (Baltimore, Md. : 1950), 1980, Volume: 125, Issue:2

    Topics: Agglutinins; Animals; Antibody-Producing Cells; Cell Transformation, Neoplastic; Female; Hypersensit

1980
Piroxicam, a potent inhibitor of prostaglandin production in cell culture. Structure-activity study.
    Prostaglandins, 1980, Volume: 19, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; In

1980
Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.
    Journal of immunology (Baltimore, Md. : 1950), 1981, Volume: 126, Issue:2

    Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cytotoxicity, Immunologic; Indomethacin;

1981
Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Aug-15, Volume: 92, Issue:17

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Avian Sarcoma Viruses; Base Sequence; C

1995
Effect of modifiers of arachidonic acid metabolism on radiation transformation and eicosanoid formation in C3H/10T1/2 cells.
    Cancer biochemistry biophysics, 1994, Volume: 14, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic

1994
Platelet activating factor induces transformation of human fibroblasts.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Alkaloids; Analysis of Variance; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Fi

1995
Cytostasis is required for IL-1 induced nitric oxide production in transformed hamster fibroblasts.
    Journal of cellular physiology, 1996, Volume: 169, Issue:3

    Topics: Animals; Arginine; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Cyto

1996
Inhibition of activator protein 1 activity and neoplastic transformation by aspirin.
    The Journal of biological chemistry, 1997, Apr-11, Volume: 272, Issue:15

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aspirin; Calcium-Calmodulin-Depende

1997
The role of linoleic acid metabolism in the proliferative response of cells overexpressing the erbB-2/HER2 oncogene.
    Advances in experimental medicine and biology, 1997, Volume: 407

    Topics: Animals; Arachidonic Acid; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; C

1997
Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.
    The Journal of experimental medicine, 1999, Aug-16, Volume: 190, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Cell Line

1999
Prostaglandin E2 production in 3T3 cells transformed by polyoma virus raises the intracellular adenosine 3':5'-monophosphate levels.
    European journal of biochemistry, 1977, Mar-15, Volume: 74, Issue:1

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Aspirin; Cell Line; Cell Transformation, Neoplastic; Cyclic AMP; In

1977
Prostaglandin production by normal and transformed 3T3 fibroblasts in cell culture.
    European journal of biochemistry, 1977, Mar-15, Volume: 74, Issue:1

    Topics: Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic; Culture Media; Indomethacin; Kinetics

1977
The effects of hydroquinone, hematin and heme-containing proteins on prostaglandin biosynthesis by methylcholanthrene-transformed mouse BALB/3T3 fibroblasts.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 197, Issue:3

    Topics: Animals; Arachidonic Acids; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Glutathio

1976
Effects of specific fatty acids on cell transformation induced by an activated c-H-ras oncogene.
    Oncogene, 1990, Volume: 5, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic; Gene Expre

1990
Quantity and saturation degree of dietary fats as modulators of oxidative stress and chemically-induced liver tumours in rats.
    International journal of cancer, 1990, Oct-15, Volume: 46, Issue:4

    Topics: Animals; Biomarkers; Blood Chemical Analysis; Cell Transformation, Neoplastic; Cholesterol; Dietary

1990
A comparison of the effects of the prostaglandin synthesis inhibitors indomethacin and carprofen on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats fed different amounts of essential fatty acid.
    Carcinogenesis, 1989, Volume: 10, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cell

1989
Inhibition of X-ray or chemical carcinogen-induced neoplastic transformation of C3H10T1/2 fibroblasts by lipopolysaccharides.
    Cancer research, 1986, Volume: 46, Issue:8

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Transformation, Neoplastic; Cells, Cultured; Fibr

1986
Spleen natural killer cell activity in mice implanted with allogeneic fibroblast-like tumour cells following in vivo exposure to beta-interferon, interleukin-1 or indomethacin.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 1987, Volume: 8, Issue:4

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Indomethacin; Interferon Type I; Interleukin-1;

1987
Inhibition by indomethacin of spontaneous mammary tumorigenesis in SHN mice.
    Breast cancer research and treatment, 1986, Volume: 8, Issue:3

    Topics: Animals; Body Weight; Cell Transformation, Neoplastic; Estrus; Female; Indomethacin; Mammary Neoplas

1986