indomethacin has been researched along with Cardiac Output, Low in 8 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Studies were conducted under control conditions and in the presence of four inhibitors of potential mediators of the reactive hyperemia response: the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (30 microM), the adenosine antagonist 8-(p-sulfophenyl)theophylline (50 microM), the K+ cyclic adenosine triphosphate-dependent channel antagonist glibenclamide (10 microM), and the cyclooxygenase inhibitor indomethacin (10 microM)." | 3.69 | Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. ( Dumont, L; Fontaine, E; Jasmin, G; Véronneau, M; Viau, S, 1997) |
| "During low cardiac output, we found a significant decrease of glomerular filtration rate, whereas renal blood flow and renal and peripheral vascular resistances were unchanged." | 1.28 | Circulatory and renal control by prostaglandins and renin in low cardiac output in dogs. ( Elsner, D; Kromer, EP; Riegger, GA, 1989) |
| "Indomethacin (5 mg/kg) was used to pretreat the support dogs and LLL donors of group II (n = 9); support dogs of group III (n = 5); and LLL donors of group IV (n = 4)." | 1.26 | Prostaglandin mediation of unstable hemodynamics during lung perfusion. ( Grindlinger, GA; Hechtman, HB; Levine, LL; Shepro, D; Utsunomiya, T; Vegas, A, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oliver, JA | 1 |
| Sciacca, RR | 1 |
| Pinto, J | 1 |
| Cannon, PJ | 1 |
| Grindlinger, GA | 1 |
| Utsunomiya, T | 1 |
| Vegas, A | 1 |
| Levine, LL | 1 |
| Shepro, D | 1 |
| Hechtman, HB | 1 |
| Schultz, HD | 2 |
| Wang, W | 3 |
| Ustinova, EE | 1 |
| Zucker, IH | 1 |
| Viau, S | 1 |
| Fontaine, E | 1 |
| Véronneau, M | 1 |
| Jasmin, G | 1 |
| Dumont, L | 1 |
| Ma, R | 1 |
| Eronen, M | 1 |
| Pesonen, E | 1 |
| Kurki, T | 1 |
| Ylikorkala, O | 1 |
| Hallman, M | 1 |
| Riegger, GA | 1 |
| Elsner, D | 1 |
| Kromer, EP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361] | Early Phase 1 | 0 participants (Actual) | Interventional | 2020-08-01 | Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for indomethacin and Cardiac Output, Low
| Article | Year |
|---|---|
The effects of indomethacin and a beta-sympathomimetic agent on the fetal ductus arteriosus during treatment of premature labor: a randomized double-blind study.
Topics: Blood Flow Velocity; Cardiac Output, Low; Delivery, Obstetric; Double-Blind Method; Ductus Arteriosu | 1991 |
7 other studies available for indomethacin and Cardiac Output, Low
| Article | Year |
|---|---|
Participation of the prostaglandins in the control of renal blood flow during acute reduction of cardiac output in the dog.
Topics: Animals; Cardiac Output, Low; Dogs; Female; Indomethacin; Kidney; Male; Meclofenamic Acid; Norepinep | 1981 |
Prostaglandin mediation of unstable hemodynamics during lung perfusion.
Topics: Animals; Cardiac Output, Low; Dogs; Hemodynamics; Hypotension; Indomethacin; Lung; Positive-Pressure | 1982 |
Enhanced responsiveness of cardiac vagal chemosensitive endings to bradykinin in heart failure.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Captopril; Cardiac Output, Low; Dogs; F | 1997 |
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity.
Topics: Animals; Cardiac Output, Low; Chronic Disease; Coronary Circulation; Cricetinae; Disease Models, Ani | 1997 |
Cardiac sympathetic afferent stimulation by bradykinin in heart failure: role of NO and prostaglandins.
Topics: Afferent Pathways; Animals; Cardiac Output, Low; Cardiac Pacing, Artificial; Cyclooxygenase Inhibito | 1998 |
Cardiac sympathetic afferent sensitivity is enhanced in heart failure.
Topics: Afferent Pathways; Animals; Bradykinin; Capsaicin; Cardiac Output, Low; Cyclooxygenase Inhibitors; D | 1999 |
Circulatory and renal control by prostaglandins and renin in low cardiac output in dogs.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Cardia | 1989 |