Page last updated: 2024-10-29

indomethacin and Cardiac Output, Low

indomethacin has been researched along with Cardiac Output, Low in 8 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.

Research Excerpts

ExcerptRelevanceReference
" Studies were conducted under control conditions and in the presence of four inhibitors of potential mediators of the reactive hyperemia response: the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (30 microM), the adenosine antagonist 8-(p-sulfophenyl)theophylline (50 microM), the K+ cyclic adenosine triphosphate-dependent channel antagonist glibenclamide (10 microM), and the cyclooxygenase inhibitor indomethacin (10 microM)."3.69Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. ( Dumont, L; Fontaine, E; Jasmin, G; VĂ©ronneau, M; Viau, S, 1997)
"During low cardiac output, we found a significant decrease of glomerular filtration rate, whereas renal blood flow and renal and peripheral vascular resistances were unchanged."1.28Circulatory and renal control by prostaglandins and renin in low cardiac output in dogs. ( Elsner, D; Kromer, EP; Riegger, GA, 1989)
"Indomethacin (5 mg/kg) was used to pretreat the support dogs and LLL donors of group II (n = 9); support dogs of group III (n = 5); and LLL donors of group IV (n = 4)."1.26Prostaglandin mediation of unstable hemodynamics during lung perfusion. ( Grindlinger, GA; Hechtman, HB; Levine, LL; Shepro, D; Utsunomiya, T; Vegas, A, 1982)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's5 (62.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Oliver, JA1
Sciacca, RR1
Pinto, J1
Cannon, PJ1
Grindlinger, GA1
Utsunomiya, T1
Vegas, A1
Levine, LL1
Shepro, D1
Hechtman, HB1
Schultz, HD2
Wang, W3
Ustinova, EE1
Zucker, IH1
Viau, S1
Fontaine, E1
VĂ©ronneau, M1
Jasmin, G1
Dumont, L1
Ma, R1
Eronen, M1
Pesonen, E1
Kurki, T1
Ylikorkala, O1
Hallman, M1
Riegger, GA1
Elsner, D1
Kromer, EP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361]Early Phase 10 participants (Actual)Interventional2020-08-01Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for indomethacin and Cardiac Output, Low

ArticleYear
The effects of indomethacin and a beta-sympathomimetic agent on the fetal ductus arteriosus during treatment of premature labor: a randomized double-blind study.
    American journal of obstetrics and gynecology, 1991, Volume: 164, Issue:1 Pt 1

    Topics: Blood Flow Velocity; Cardiac Output, Low; Delivery, Obstetric; Double-Blind Method; Ductus Arteriosu

1991

Other Studies

7 other studies available for indomethacin and Cardiac Output, Low

ArticleYear
Participation of the prostaglandins in the control of renal blood flow during acute reduction of cardiac output in the dog.
    The Journal of clinical investigation, 1981, Volume: 67, Issue:1

    Topics: Animals; Cardiac Output, Low; Dogs; Female; Indomethacin; Kidney; Male; Meclofenamic Acid; Norepinep

1981
Prostaglandin mediation of unstable hemodynamics during lung perfusion.
    Surgery, 1982, Volume: 92, Issue:1

    Topics: Animals; Cardiac Output, Low; Dogs; Hemodynamics; Hypotension; Indomethacin; Lung; Positive-Pressure

1982
Enhanced responsiveness of cardiac vagal chemosensitive endings to bradykinin in heart failure.
    The American journal of physiology, 1997, Volume: 273, Issue:2 Pt 2

    Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Captopril; Cardiac Output, Low; Dogs; F

1997
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity.
    Journal of cardiac failure, 1997, Volume: 3, Issue:3

    Topics: Animals; Cardiac Output, Low; Chronic Disease; Coronary Circulation; Cricetinae; Disease Models, Ani

1997
Cardiac sympathetic afferent stimulation by bradykinin in heart failure: role of NO and prostaglandins.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: Afferent Pathways; Animals; Cardiac Output, Low; Cardiac Pacing, Artificial; Cyclooxygenase Inhibito

1998
Cardiac sympathetic afferent sensitivity is enhanced in heart failure.
    The American journal of physiology, 1999, Volume: 277, Issue:2

    Topics: Afferent Pathways; Animals; Bradykinin; Capsaicin; Cardiac Output, Low; Cyclooxygenase Inhibitors; D

1999
Circulatory and renal control by prostaglandins and renin in low cardiac output in dogs.
    The American journal of physiology, 1989, Volume: 256, Issue:4 Pt 2

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Cardia

1989