indomethacin has been researched along with Carcinoma, Lewis Lung in 5 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Carcinoma, Lewis Lung: A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report that indomethacin, a nonspecific inhibitor of COX, and NS398, a specific inhibitor of COX2, preserved muscle mass and reduced type 1 TNF receptors in muscles of mice bearing the Lewis lung carcinoma, but not in mice bearing the B16 melanoma." | 3.73 | Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma. ( Graves, E; McCarthy, DO; Ramsay, E, 2006) |
| "Indomethacin is a kind of NSAIDs and has anti-tumor effect." | 1.56 | Pharmacokinetics-based analysis of indomethacin's anti-tumor effect and drug efficacy. ( Jingjing, G; Jun, Z; Ke, L; Yan, Z; Zhu, Z, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, Z | 1 |
| Jun, Z | 1 |
| Zhu, Z | 1 |
| Jingjing, G | 1 |
| Ke, L | 1 |
| Lu, G | 1 |
| Zhang, G | 1 |
| Zhang, C | 1 |
| Chen, C | 1 |
| Liu, R | 1 |
| Graves, E | 1 |
| Ramsay, E | 1 |
| McCarthy, DO | 1 |
| Kudriavtsev, IA | 1 |
| Miasishcheva, NV | 1 |
| Blaya, C | 1 |
| Crespo, J | 1 |
| Crespo, A | 1 |
| Aliño, SF | 1 |
5 other studies available for indomethacin and Carcinoma, Lewis Lung
| Article | Year |
|---|---|
Pharmacokinetics-based analysis of indomethacin's anti-tumor effect and drug efficacy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; bcl-2-Associated X Protein; | 2020 |
A study of 131iodine-labeling of histamine-indomethacin: its in vivo therapeutic effect and anti-tumor mechanisms in Lewis-bearing lung cancer.
Topics: Animals; Antineoplastic Agents; Autoradiography; Carcinoma, Lewis Lung; Histamine; Indomethacin; Iod | 2013 |
Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma.
Topics: Analysis of Variance; Animals; Cachexia; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Female; I | 2006 |
[Synthesis of arachidonic acid cascade eicosanoids in tumors of various histogenesis in mice].
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenocarcinoma; Animals; Arachidonic Acid; Carcinoma, Le | 1995 |
Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinoma, Lewis Lung; Cell Division; Cycloo | 1998 |