indomethacin has been researched along with Carcinoma, Hepatocellular in 29 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, we aimed to evaluate novel indomethacin derivatives for the treatment of hepatocellular carcinoma." | 8.02 | Functional Role of Novel Indomethacin Derivatives for the Treatment of Hepatocellular Carcinoma Through Inhibition of Platelet-Derived Growth Factor. ( Chavda, V; Nanavati, P; Patel, S; Savjani, J; Sharma, J, 2021) |
| " The authors report a patient with hepatocellular carcinoma associated with diarrhea mediated by prostaglandins, surviving 30 months after receiving treatment with indomethacin and Adriamycin." | 7.67 | Long survival of diarrhea-associated hepatocarcinoma treated with Adriamycin and indomethacin. A case report. ( Barcena, R; Boixeda, D; Moreno, A; Saban, J; Serrano-Rios, M, 1986) |
| "Twenty-one patients with advanced hepatocellular carcinoma were randomly divided into two groups." | 6.69 | [Effect of indomethacin on natural killer(NK) cell and T lymphocyte subsets from patients with hepatocellular carcinoma]. ( Chen, FY; Yuan, WJ; Zhang, GY, 2000) |
| "Indomethacin pretreatment is used as a potential chemopreventive agent in cancers for it could assist in anti-tumor functions of other agents and exert anti-tumor effect." | 5.42 | Long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-κB pathway and JAK/STAT3 pathway to inhibit TNF-α and IFN-γ in hepatocellular carcinoma. ( Miao, C; Sun, Z; Wang, Y; Xu, P, 2015) |
| "Pretreatment with tocopheryl nicotinate and indomethacin increased the K values in the control subjects, but was without effect on the K values in patients with primary hepatoma." | 5.26 | Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma. ( Hobara, N; Watanabe, A, 1979) |
| " Therefore, we aimed to evaluate novel indomethacin derivatives for the treatment of hepatocellular carcinoma." | 4.02 | Functional Role of Novel Indomethacin Derivatives for the Treatment of Hepatocellular Carcinoma Through Inhibition of Platelet-Derived Growth Factor. ( Chavda, V; Nanavati, P; Patel, S; Savjani, J; Sharma, J, 2021) |
| " Therefore, the purpose of the present study was to determine if administration of ibuprofen (ibu) or indomethacin (indo), which inhibit PG synthesis, would affect the food intake and body weight of tumor-bearing rats." | 3.70 | Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats. ( McCarthy, DO, 1999) |
| "The PGE2 concentration of sera and tumor tissues in human hepatocellular carcinoma (hHCC) xenografts in nude mice was examined by radio-immuno-assay (RIA) and the effect of intraperitoneal administration of exogenous of PGE2 as well as indomethacin on tumor growth was studied." | 3.68 | [In vivo studies on PGE2 production by human hepatocellular carcinoma xenografts in nude mice]. ( Shi, LH, 1993) |
| "In order to investigate the production of PGE2 and its' function in human hepatocellular carcinoma, the effects of indomethacin and PGE2 on tumor growth were examined using in vivo and in vitro techniques." | 3.67 | [In vivo and in vitro studies on PGE2 production and function in human hepatocellular carcinoma]. ( Itakura, M; Nakase, A; Nohara, T, 1989) |
| " The authors report a patient with hepatocellular carcinoma associated with diarrhea mediated by prostaglandins, surviving 30 months after receiving treatment with indomethacin and Adriamycin." | 3.67 | Long survival of diarrhea-associated hepatocarcinoma treated with Adriamycin and indomethacin. A case report. ( Barcena, R; Boixeda, D; Moreno, A; Saban, J; Serrano-Rios, M, 1986) |
| "Twenty-one patients with advanced hepatocellular carcinoma were randomly divided into two groups." | 2.69 | [Effect of indomethacin on natural killer(NK) cell and T lymphocyte subsets from patients with hepatocellular carcinoma]. ( Chen, FY; Yuan, WJ; Zhang, GY, 2000) |
| "Indomethacin pretreatment is used as a potential chemopreventive agent in cancers for it could assist in anti-tumor functions of other agents and exert anti-tumor effect." | 1.42 | Long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-κB pathway and JAK/STAT3 pathway to inhibit TNF-α and IFN-γ in hepatocellular carcinoma. ( Miao, C; Sun, Z; Wang, Y; Xu, P, 2015) |
| "Pretreatment with indomethacin had no significant effect on tumour take or initial growth." | 1.29 | Influence of zymosan (a non-specific macrophage stimulator) and of indomethacin on liver tumours--an experimental study in rats. ( Daneryd, PL; Hafström, LR; Holmberg, SB; Karlberg, IH; Karlsson, LM; Lindnér, GO; Naredi, PL; Pettersson, A; Stenram, U, 1995) |
| "By an autopsy, hepatocellular carcinoma was found in the right lobe of the liver." | 1.27 | Prostaglandin-E-producing hepatocellular carcinoma with hypercalcemia. ( Hasumura, Y; Ikeda, T; Takeuchi, J; Tozuka, S, 1988) |
| "Pretreatment with tocopheryl nicotinate and indomethacin increased the K values in the control subjects, but was without effect on the K values in patients with primary hepatoma." | 1.26 | Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma. ( Hobara, N; Watanabe, A, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (31.03) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 8 (27.59) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, WY | 1 |
| Cheung, CC | 1 |
| Liu, KW | 1 |
| Fung, KP | 2 |
| Wong, J | 1 |
| Lai, PB | 1 |
| Yeung, JH | 2 |
| Zhang, L | 2 |
| Liu, L | 1 |
| Zheng, C | 1 |
| Wang, Y | 2 |
| Nie, X | 1 |
| Shi, D | 1 |
| Chen, Y | 1 |
| Wei, G | 1 |
| Wang, J | 1 |
| Peng, X | 1 |
| Gao, J | 1 |
| Yuan, Y | 1 |
| Liu, H | 1 |
| Lei, W | 1 |
| Li, S | 1 |
| Zhang, J | 1 |
| Wang, S | 1 |
| Patel, S | 1 |
| Nanavati, P | 1 |
| Sharma, J | 1 |
| Chavda, V | 1 |
| Savjani, J | 1 |
| Xu, P | 1 |
| Sun, Z | 1 |
| Miao, C | 1 |
| Ye, CG | 1 |
| Wu, WK | 1 |
| Li, HT | 1 |
| Li, ZJ | 1 |
| Wong, CC | 1 |
| Ren, SX | 1 |
| Cho, CH | 1 |
| Yuan, WJ | 1 |
| Chen, FY | 1 |
| Zhang, GY | 1 |
| Tabernero, A | 1 |
| Schneider, F | 1 |
| Potenza, MA | 1 |
| Randriamboavonjy, V | 1 |
| Chasserot, S | 1 |
| Wolf, P | 1 |
| Mitolo-Chieppa, D | 1 |
| Stoclet, JC | 1 |
| Andriantsitohaina, R | 1 |
| Horani, MH | 1 |
| Gobal, F | 1 |
| Haas, MJ | 1 |
| Wong, NC | 1 |
| Mooradian, AD | 1 |
| Park, WH | 1 |
| Joo, ST | 1 |
| Park, KK | 1 |
| Chang, YC | 1 |
| Kim, CH | 1 |
| Romeu, J | 1 |
| Chadha, N | 1 |
| Fukilman, O | 1 |
| Dave, P | 1 |
| Lee, M | 1 |
| Mahmud, I | 1 |
| Miura, Y | 1 |
| Holmberg, SB | 1 |
| Naredi, PL | 1 |
| Lindnér, GO | 1 |
| Karlberg, IH | 1 |
| Daneryd, PL | 1 |
| Karlsson, LM | 1 |
| Pettersson, A | 1 |
| Stenram, U | 1 |
| Hafström, LR | 1 |
| Conti, P | 2 |
| Bartle, L | 2 |
| Barbacane, RC | 2 |
| Reale, M | 2 |
| Sipe, JD | 1 |
| Placido, FC | 1 |
| Sipe, J | 1 |
| Kasckow, JW | 1 |
| Mulcahey, JJ | 1 |
| Han, JH | 1 |
| Owens, MJ | 1 |
| Stipetic, MD | 1 |
| Breitman, D | 1 |
| Nemeroff, CB | 1 |
| Shi, LH | 1 |
| McCarthy, DO | 1 |
| Zhang, K | 1 |
| Chew, M | 1 |
| Yang, EB | 1 |
| Wong, KP | 1 |
| Mack, P | 1 |
| Kilic, G | 1 |
| Fitz, JG | 1 |
| Sekhar, KR | 1 |
| Spitz, DR | 1 |
| Harris, S | 1 |
| Nguyen, TT | 1 |
| Meredith, MJ | 1 |
| Holt, JT | 1 |
| Gius, D | 1 |
| Marnett, LJ | 1 |
| Summar, ML | 1 |
| Freeman, ML | 1 |
| Guis, D | 1 |
| Marinho, R | 1 |
| Pinto, R | 1 |
| Santos, ML | 1 |
| de, M | 1 |
| Hobara, N | 1 |
| Watanabe, A | 1 |
| Itakura, M | 1 |
| Nohara, T | 1 |
| Nakase, A | 1 |
| Ikeda, T | 1 |
| Tozuka, S | 1 |
| Hasumura, Y | 1 |
| Takeuchi, J | 1 |
| Abe, S | 1 |
| Saban, J | 1 |
| Boixeda, D | 1 |
| Moreno, A | 1 |
| Barcena, R | 1 |
| Serrano-Rios, M | 1 |
| Yokota, M | 1 |
| Sakamoto, S | 1 |
| Koga, S | 1 |
| Ibayashi, H | 1 |
| Apps, MC | 1 |
| Cater, DB | 1 |
1 trial available for indomethacin and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
[Effect of indomethacin on natural killer(NK) cell and T lymphocyte subsets from patients with hepatocellular carcinoma].
Topics: Adjuvants, Immunologic; Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Fem | 2000 |
28 other studies available for indomethacin and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxor | 2010 |
Synthesis and biological evaluation of novel podophyllotoxin-NSAIDs conjugates as multifunctional anti-MDR agents against resistant human hepatocellular carcinoma Bel-7402/5-FU cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line | 2017 |
Hypoxia-Activated and Indomethacin-Mediated Theranostic Prodrug Releasing Drug On-Demand for Tumor Imaging and Therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; | 2019 |
Functional Role of Novel Indomethacin Derivatives for the Treatment of Hepatocellular Carcinoma Through Inhibition of Platelet-Derived Growth Factor.
Topics: Carcinoma, Hepatocellular; Humans; Indomethacin; Liver Neoplasms; Molecular Docking Simulation; Plat | 2021 |
Long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-κB pathway and JAK/STAT3 pathway to inhibit TNF-α and IFN-γ in hepatocellular carcinoma.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, | 2015 |
Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Tr | 2011 |
Cyclooxygenase-2 and inducible nitric oxide synthase in omental arteries harvested from patients with severe liver diseases: immuno-localization and influence on vascular tone.
Topics: Adult; Arteries; Blotting, Western; Carcinoma, Hepatocellular; Case-Control Studies; Cyclooxygenase | 2003 |
Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2.
Topics: Apolipoprotein A-I; Arachidonic Acid; Aspirin; Blotting, Northern; Blotting, Western; Carcinoma, Hep | 2004 |
Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Hepat | 2004 |
Indomethacin therapy in symptomatic hepatic neoplasms.
Topics: Adenocarcinoma; Aged; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Female; Humans; Indometha | 1982 |
Effects of stimulators and inhibitors on arachidonic acid metabolism in hepatoma.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Butylated Hydroxytoluene; Carcinoma, Hepatoce | 1981 |
Influence of zymosan (a non-specific macrophage stimulator) and of indomethacin on liver tumours--an experimental study in rats.
Topics: Adenocarcinoma; Animals; Carcinoma, Hepatocellular; Drug Interactions; Drug Therapy, Combination; In | 1995 |
The down-regulation of IL-6-stimulated fibrinogen steady state mRNA and protein levels by human recombinant IL-1 is not PGE2-dependent: effects of IL-1 receptor antagonist (IL-1RA).
Topics: Arachidonic Acid; Carcinoma, Hepatocellular; Dinoprostone; Down-Regulation; Fibrinogen; Gene Express | 1995 |
Synergistic activation of serum amyloid A (SAA) by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line. Role of PGE2 and IL-1 receptor antagonist.
Topics: Arachidonic Acid; Blotting, Northern; Carcinoma, Hepatocellular; Dinoprostone; Drug Synergism; Enzym | 1995 |
Interleukin-1 alpha induces corticotropin-releasing factor secretion and synthesis from NPLC-KC cells through various second messenger pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Corticotropin-Releasing Ho | 1994 |
[In vivo studies on PGE2 production by human hepatocellular carcinoma xenografts in nude mice].
Topics: Animals; Carcinoma, Hepatocellular; Dinoprostone; Humans; Indomethacin; Injections, Intraperitoneal; | 1993 |
Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats.
Topics: Analysis of Variance; Animals; Anorexia; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cache | 1999 |
Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms.
Topics: Biological Transport; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Carrier Proteins; Cisplatin | 2001 |
Heterotrimeric G-proteins activate Cl- channels through stimulation of a cyclooxygenase-dependent pathway in a model liver cell line.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Arachidonic Acid; Calcium; Carcinoma, He | 2002 |
Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Carcinoma, Hepatocellular; Carrier Prot | 2002 |
Evidence for prostaglandin-producing supressor cells in HCV patients with normal ALT.
Topics: Alanine Transaminase; Carcinoma, Hepatocellular; Carrier State; Dinoprostone; Hepatitis C Antigens; | 2002 |
Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Fluorouracil; Humans; Indomethacin; Kinetics; Liver Cirrhosis; Liver Neop | 1979 |
[In vivo and in vitro studies on PGE2 production and function in human hepatocellular carcinoma].
Topics: Animals; Carcinoma, Hepatocellular; Dinoprostone; Humans; Indomethacin; Liver Neoplasms; Male; Mice; | 1989 |
Prostaglandin-E-producing hepatocellular carcinoma with hypercalcemia.
Topics: Aged; Carcinoma, Hepatocellular; Humans; Hypercalcemia; Indomethacin; Liver Neoplasms; Male; Phospha | 1988 |
Effects of arachidonic acid and indomethacin on sister-chromatid exchange induction by polycyclic aromatic hydrocarbons in mammalian cell lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonic Acid; Arachidonic Acids; Aryl Hydrocarbon Hyd | 1986 |
Long survival of diarrhea-associated hepatocarcinoma treated with Adriamycin and indomethacin. A case report.
Topics: Adult; Carcinoma, Hepatocellular; Diarrhea; Doxorubicin; Drug Therapy, Combination; Humans; Indometh | 1986 |
Decreased interleukin 1 activity in culture supernatant of lipopolysaccharide stimulated monocytes from patients with liver cirrhosis and hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Body Temperature; C-Reactive Protein; Carcinoma, Hepatocellular; Din | 1987 |
Production of histamine-like and prostaglandin-like substances from serum incubated with rat, dog, mouse or human tumours.
Topics: Acetates; Animals; Aspirin; Carcinoma, Hepatocellular; Complement System Proteins; Dogs; Histamine; | 1973 |