indomethacin has been researched along with Carcinoma, Anaplastic in 38 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The modulating activity of indomethacin to vincristine (VCR) was investigated in thirty human pulmonary carcinoma cell lines (adenocarcinoma 9, large cell carcinoma 9, squamous cell carcinoma 6, small cell carcinoma 6) and five other cell lines (colon carcinoma 2, melanoma 1, teratocarcinoma 1, thymoma 1)." | 7.70 | Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells. ( Fujimura, S; Hasumi, T; Kobayashi, S; Okada, S; Sato, N, 1998) |
| " with NC carcinoma were treated with 16,16-dimethyl prostaglandin E2 methyl ester (di-me-PGE2) and/or indomethacin." | 7.67 | Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin. ( Bennett, A; Carroll, MA; Melhuish, PB; Stamford, IF, 1985) |
| " Here, we show that baicalein (selective 12-lipoxygenase inhibitor), nordihydroguaiaretic acid (non-selective lipoxygenase inhibitor), and indomethacin (non-selective cyclooxygenase inhibitor) are cytotoxic to Ehrlich carcinoma cells in vitro." | 3.96 | α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors. ( Balashevich, T; Osipov, AV; Terpinskaya, TI; Tsetlin, VI; Utkin, YN; Yanchanka, T; Zhmak, MN, 2020) |
| " In AMC-HN5 human sinonasal carcinoma cells, indomethacin was the most potent NAG-1 inducer and caused NAG-1 expression in a time- and dose-dependent manner." | 3.74 | Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. ( Chang, JH; Cho, CI; Jeon, JH; Kim, JH; Kim, KS; Kwon, SH; Lee, KW; Rhee, KH; Song, K; Yoon, JH, 2008) |
| "The modulating activity of indomethacin to vincristine (VCR) was investigated in thirty human pulmonary carcinoma cell lines (adenocarcinoma 9, large cell carcinoma 9, squamous cell carcinoma 6, small cell carcinoma 6) and five other cell lines (colon carcinoma 2, melanoma 1, teratocarcinoma 1, thymoma 1)." | 3.70 | Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells. ( Fujimura, S; Hasumi, T; Kobayashi, S; Okada, S; Sato, N, 1998) |
| "Irradiated tumor cells given, together with indomethacin, to syngeneic mice induced an antitumor response and conferred protection against a challenge of a lethal dose of murine mammary (4T1) and lung (3LL) carcinoma cells." | 3.70 | Induction of antitumor immunity by indomethacin. ( Gelfand, Y; Morecki, S; Shohami, E; Slavin, S; Trembovler, V; Yacovlev, E, 2000) |
| " The effect of folate on the interaction between methotrexate (a folate analogue) and indomethacin has been examined in murine NC carcinoma cells." | 3.69 | The effect of folate on the methotrexate/indomethacin interaction in a murine cancer cell line. ( Anderson, EM; Bennett, A; Hollingsworth, SJ, 1995) |
| "Indomethacine, protamine-sulphate and hydrocortisone were found to decrease the activity of metastatic processes of Lewis carcinoma after the removal of the primary tumour." | 3.67 | [Effect of actions inhibiting neovascularization of the metastasis of Lewis lung carcinoma]. ( Balitskiĭ, KP; Lisniak, IA; Sopotsinskaia, EB, 1985) |
| "The histamine-2 receptor antagonist cimetidine (10(-5)M) and the prostaglandin synthesis inhibitor indomethacin (10(-8)M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma." | 3.67 | Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. ( Flodgren, P; Sjögren, HO, 1985) |
| " No statistically significant difference in delayed hypersensitivity response to dinitrochlorobenzene was found between indomethacin-treated, tumor-bearing and control groups." | 3.67 | Indomethacin and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in the hamster buccal pouch. ( Gould, AR; Grant, FT; Miller, RL; Perry, DA, 1985) |
| " with NC carcinoma were treated with 16,16-dimethyl prostaglandin E2 methyl ester (di-me-PGE2) and/or indomethacin." | 3.67 | Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin. ( Bennett, A; Carroll, MA; Melhuish, PB; Stamford, IF, 1985) |
| "LADG for early gastric cancer is a feasible and safe procedure with short-term clinical results superior to those of ODG." | 2.78 | Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial. ( Bax, L; Futawatari, N; Katada, N; Kikuchi, S; Okutomi, T; Sakuramoto, S; Wang, G; Watanabe, M; Yamashita, K, 2013) |
| "Relapse of castration-resistant prostate cancer (CRPC) that occurs after androgen deprivation therapy of primary prostate cancer can be mediated by reactivation of the androgen receptor (AR)." | 1.37 | Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. ( Balk, SP; Bubley, GJ; Cai, C; Chen, S; Marck, B; Matsumoto, AM; Mostaghel, EA; Nelson, PS; Ng, P; Simon, NI; Wang, H, 2011) |
| "An animal model of cancer pain induced by injection of Walker 256 carcinoma cells into the plantar surface of rat hind paw is described." | 1.34 | Walker 256 tumor-bearing rats as a model to study cancer pain. ( Brigatte, P; Curi, R; Cury, Y; Guerra, JL; Gutierrez, VP; Sampaio, SC; Sinhorini, IL, 2007) |
| " Chronic administration of indomethacin in the drinking water at 10 micrograms/ml potentiated the MVE-5 antitumor induced macrophage activation in vivo." | 1.27 | Potentiation of nonspecific immunotherapy of experimental lung metastases by indomethacin. ( Altom, MG; Schultz, RM, 1983) |
| "The production of bone resorption-stimulating activity and PGE2 by VX2 cells in culture were both inhibited by indomethacin (100 ng/ml)." | 1.25 | Hypercalcemia and tumor-prostaglandins: the VX2 carcinoma model in the rabbit. ( Franklin, R; Levine, L; Tashjian, AH; Voelkel, EF; Wasserman, E, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (52.63) | 18.7374 |
| 1990's | 6 (15.79) | 18.2507 |
| 2000's | 7 (18.42) | 29.6817 |
| 2010's | 4 (10.53) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Osipov, AV | 1 |
| Terpinskaya, TI | 1 |
| Yanchanka, T | 1 |
| Balashevich, T | 1 |
| Zhmak, MN | 1 |
| Tsetlin, VI | 1 |
| Utkin, YN | 1 |
| Chiou, SK | 1 |
| Hoa, N | 1 |
| Hodges, A | 1 |
| Ge, L | 1 |
| Jadus, MR | 1 |
| Cai, C | 1 |
| Chen, S | 2 |
| Ng, P | 1 |
| Bubley, GJ | 1 |
| Nelson, PS | 1 |
| Mostaghel, EA | 1 |
| Marck, B | 1 |
| Matsumoto, AM | 1 |
| Simon, NI | 1 |
| Wang, H | 1 |
| Balk, SP | 1 |
| Lönnroth, C | 1 |
| Andersson, M | 1 |
| Nordgren, S | 1 |
| Lundholm, K | 1 |
| Sakuramoto, S | 1 |
| Yamashita, K | 1 |
| Kikuchi, S | 1 |
| Futawatari, N | 1 |
| Katada, N | 1 |
| Watanabe, M | 1 |
| Okutomi, T | 1 |
| Wang, G | 1 |
| Bax, L | 1 |
| Roh, JL | 1 |
| Sung, MW | 1 |
| Kim, KH | 1 |
| Kobayashi, S | 2 |
| Nantz, R | 1 |
| Kitamura, T | 1 |
| Higashikubo, R | 1 |
| Horikoshi, N | 1 |
| Yoshii, M | 1 |
| Jikuhara, A | 1 |
| Mori, S | 1 |
| Iwagaki, H | 1 |
| Takahashi, HK | 1 |
| Nishibori, M | 1 |
| Tanaka, N | 1 |
| Brigatte, P | 1 |
| Sampaio, SC | 1 |
| Gutierrez, VP | 1 |
| Guerra, JL | 1 |
| Sinhorini, IL | 1 |
| Curi, R | 1 |
| Cury, Y | 1 |
| Kim, JH | 1 |
| Chang, JH | 1 |
| Rhee, KH | 1 |
| Yoon, JH | 1 |
| Kwon, SH | 1 |
| Song, K | 1 |
| Lee, KW | 1 |
| Cho, CI | 1 |
| Jeon, JH | 1 |
| Kim, KS | 1 |
| Doppelt, SH | 1 |
| Slovik, DM | 1 |
| Neer, RM | 1 |
| Nolan, J | 1 |
| Zusman, RM | 1 |
| Potts, JT | 1 |
| Schultz, RM | 1 |
| Altom, MG | 1 |
| Hagiwara, M | 1 |
| McNamara, DB | 1 |
| Chen, IL | 1 |
| Fisher, JW | 1 |
| Han, T | 1 |
| Takita, H | 1 |
| Panje, WR | 1 |
| Buick, RN | 1 |
| Fry, SE | 1 |
| Salmon, SE | 1 |
| Hollingsworth, SJ | 1 |
| Anderson, EM | 1 |
| Bennett, A | 2 |
| Meng, CL | 1 |
| Yang, CY | 1 |
| Shen, KL | 1 |
| Wong, PY | 1 |
| Lee, HK | 1 |
| Okada, S | 1 |
| Hasumi, T | 1 |
| Sato, N | 1 |
| Fujimura, S | 1 |
| Morecki, S | 1 |
| Yacovlev, E | 1 |
| Gelfand, Y | 1 |
| Trembovler, V | 1 |
| Shohami, E | 1 |
| Slavin, S | 1 |
| Boström, PJ | 1 |
| Aaltonen, V | 1 |
| Söderström, KO | 1 |
| Uotila, P | 1 |
| Laato, M | 1 |
| Voelkel, EF | 2 |
| Levine, L | 2 |
| Alper, CA | 1 |
| Tashjian, AH | 2 |
| Franklin, R | 1 |
| Wasserman, E | 1 |
| Rahal, MD | 1 |
| Reinish, E | 1 |
| Osmond, DG | 1 |
| Aliño, SF | 1 |
| Unda, FJ | 1 |
| Iruarrizaga, A | 1 |
| Alfaro, J | 1 |
| Hilario, E | 1 |
| Pérez-Yarza, G | 1 |
| Bobadilla, M | 1 |
| Lejarreta, M | 1 |
| Fariñas, MC | 1 |
| Rodriguez-Valverde, V | 1 |
| Zarrabeitia, MT | 1 |
| Parra-Blanco, JA | 1 |
| Sanz-Ortiz, J | 1 |
| Sopotsinskaia, EB | 1 |
| Lisniak, IA | 1 |
| Balitskiĭ, KP | 1 |
| Karczag, E | 2 |
| Minárovits, J | 2 |
| Földes, I | 2 |
| Yron, I | 1 |
| Schickler, M | 1 |
| Fisch, B | 1 |
| Pinkas, H | 1 |
| Ovadia, J | 1 |
| Witz, IP | 1 |
| Young, MR | 1 |
| Endicott, RA | 1 |
| Duffie, GP | 1 |
| Wepsic, HT | 1 |
| Flodgren, P | 1 |
| Sjögren, HO | 1 |
| Yoneda, T | 1 |
| Kitamura, M | 1 |
| Ogawa, T | 1 |
| Aya, S | 1 |
| Sakuda, M | 1 |
| Gould, AR | 1 |
| Miller, RL | 1 |
| Grant, FT | 1 |
| Perry, DA | 1 |
| Carroll, MA | 1 |
| Melhuish, PB | 1 |
| Stamford, IF | 1 |
| Thomas, DR | 1 |
| Philpott, GW | 1 |
| Jaffe, BM | 3 |
| Cohen, F | 1 |
1 review available for indomethacin and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Prostaglandins and cancer: an update.
Topics: Animals; Aspirin; Bucladesine; Calcium; Carcinoma; Cell Division; Cell Line; Depression, Chemical; H | 1974 |
1 trial available for indomethacin and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial.
Topics: Administration, Rectal; Aged; Analgesia, Patient-Controlled; Analgesics; Carcinoma; Comorbidity; Cri | 2013 |
36 other studies available for indomethacin and Carcinoma, Anaplastic
| Article | Year |
|---|---|
α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors.
Topics: Animals; Arachidonic Acid; Carcinoma; Carcinoma, Ehrlich Tumor; Cell Survival; Cobra Neurotoxin Prot | 2020 |
Indomethacin promotes apoptosis in gastric cancer cells through concomitant degradation of Survivin and Aurora B kinase proteins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Aurora Kinase | 2014 |
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.
Topics: Androstenedione; Androstenes; Androstenols; Animals; Antineoplastic Agents, Hormonal; Carcinoma; Cel | 2011 |
Downregulation of Prominin 1/CD133 expression in colorectal cancer by NSAIDs following short-term preoperative treatment.
Topics: AC133 Antigen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Bioma | 2012 |
Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Carcinoma, Squamous Cell; Celecoxib; Ce | 2005 |
Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation.
Topics: Carcinoma; Colonic Neoplasms; DNA Replication; Extracellular Signal-Regulated MAP Kinases; HeLa Cell | 2005 |
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxyg | 2005 |
Walker 256 tumor-bearing rats as a model to study cancer pain.
Topics: Animals; Carcinoma; Cell Line, Tumor; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethaci | 2007 |
Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Blotting, Wester | 2008 |
Gut-mediated hypercalcemia in rabbits bearing VX2 carcinoma: new mechanism for tumor-induced hypercalcemia.
Topics: Animals; Carcinoma; Clodronic Acid; Hypercalcemia; Indomethacin; Male; Neoplasms, Experimental; Pros | 1982 |
Potentiation of nonspecific immunotherapy of experimental lung metastases by indomethacin.
Topics: Animals; Carcinoma; Cyclooxygenase Inhibitors; Drug Synergism; Immunotherapy; Indomethacin; Lung Neo | 1983 |
Role of endogenous prostaglandin E2 in erythropoietin production and dome formation by human renal carcinoma cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinoma; Cell Transformation, Neoplastic; Cells, Cul | 1984 |
Indomethacin-mediated enhancement of lymphocyte response to mitogens in healthy subjects and lung cancer patients.
Topics: Adult; Aged; Carcinoma; Concanavalin A; Dose-Response Relationship, Drug; Female; Humans; Indomethac | 1980 |
Regression of head and neck carcinoma with a prostaglandin-synthesis inhibitor.
Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Head and N | 1981 |
Effect of host-cell interactions on clonogenic carcinoma cells in human malignant effusions.
Topics: Ascitic Fluid; Carcinoma; Cell Adhesion; Cell Count; Cell Fractionation; Clone Cells; Female; Hemato | 1980 |
The effect of folate on the methotrexate/indomethacin interaction in a murine cancer cell line.
Topics: Animals; Carcinoma; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Folic Acid; Indo | 1995 |
Inhibition of the synthesis of eicosanoid-like substances in a human oral cancer cell line by interferon-gamma and eicosapentaenoic acid.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Analysis of Variance; Arachidonic Acids; Carcinoma; Chromatography, | 1998 |
Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Carcinoma; | 1998 |
Induction of antitumor immunity by indomethacin.
Topics: Adjuvants, Immunologic; Animals; Cancer Vaccines; Carcinoma; Cyclooxygenase Inhibitors; Cytotoxicity | 2000 |
Expression of cyclooxygenase-1 and -2 in urinary bladder carcinomas in vivo and in vitro and prostaglandin E2 synthesis in cultured bladder cancer cells.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Re | 2001 |
Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2 carcinoma.
Topics: Animals; Carcinoma; Ceruloplasmin; Female; Haptoglobins; Indomethacin; Neoplasms, Experimental; Pros | 1978 |
Hypercalcemia and tumor-prostaglandins: the VX2 carcinoma model in the rabbit.
Topics: Animals; Biological Assay; Bone Resorption; Carcinoma; Disease Models, Animal; Femoral Vein; Hyperca | 1975 |
Changes in the populations of null, NK1.1+, and Thy1lo lymphocytes in the bone marrow of tumor-bearing mice: effect of indomethacin treatment.
Topics: Animals; Antigens, Surface; Bone Marrow; Carcinoma; Carcinoma, Ehrlich Tumor; Indomethacin; Killer C | 1992 |
Efficacy of liposome-encapsulated indomethacin in response against metastatic 3LL and B16F1 tumor cells.
Topics: Animals; Carcinoma; Chromatography, High Pressure Liquid; Dinoprostone; Drug Carriers; Indomethacin; | 1992 |
Contribution of monocytes to the decreased lymphoproliferative response to phytohemagglutinin in patients with lung cancer.
Topics: Adenocarcinoma; Aged; Carcinoma; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; Int | 1991 |
[Effect of actions inhibiting neovascularization of the metastasis of Lewis lung carcinoma].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Drug Evaluation, Preclinical; Hy | 1985 |
Comparison of the effects of peritoneal and spleen cells of syngeneic or allogeneic origin on the take of transplantable murine tumours.
Topics: Acenocoumarol; Adenocarcinoma; Animals; Carcinoma; Indomethacin; Mice; Mice, Inbred BALB C; Mice, In | 1989 |
Characterization of activated peritoneal cells inhibiting the take of transplantable murine tumours.
Topics: Acenocoumarol; Adenocarcinoma; Animals; Antibodies; Carcinoma; Complement System Proteins; Female; G | 1989 |
The immune system during the pre-cancer and the early cancer period. IL-2 production by PBL from post-menopausal women with and without endometrial carcinoma.
Topics: B-Lymphocytes; Carcinoma; Female; Humans; Indomethacin; Interleukin-2; Lymphocyte Activation; Macrop | 1986 |
Suppressor alveolar macrophages in mice bearing metastatic Lewis lung carcinoma tumors.
Topics: Animals; Antioxidants; Carcinoma; Female; Immune Tolerance; Indomethacin; Killer Cells, Natural; Lun | 1987 |
Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.
Topics: Antibody-Dependent Cell Cytotoxicity; Carcinoma; Cimetidine; Colonic Neoplasms; Cytotoxicity, Immuno | 1985 |
Control of VX2 carcinoma cell growth in culture by calcium, calmodulin, and prostaglandins.
Topics: Animals; Bone Resorption; Calcimycin; Calcium; Calmodulin; Carcinoma; Cell Division; Cell Line; DNA | 1985 |
Indomethacin and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in the hamster buccal pouch.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cheek; Cricetinae; Dinitrochlorobenzene; Drug | 1985 |
Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Carcinoma; Indomethacin; Male; Mice; Mice, Inbred Strains; | 1985 |
The relationship between concentration of prostaglandin E and rates of cell replication.
Topics: Animals; Bucladesine; Carcinoma; Cell Division; Cell Line; Depression, Chemical; Female; HeLa Cells; | 1974 |
Production of prostaglandins by cells in vitro: radioimmunoassay measurement of the conversion of arachidonic acid to PGE2 and PGF2 alpha.
Topics: Animals; Arachidonic Acids; Carcinoma; Cell Line; Colon; Gastric Mucosa; HeLa Cells; Humans; Indomet | 1973 |