Page last updated: 2024-10-29

indomethacin and Carcinoma, Anaplastic

indomethacin has been researched along with Carcinoma, Anaplastic in 38 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"The modulating activity of indomethacin to vincristine (VCR) was investigated in thirty human pulmonary carcinoma cell lines (adenocarcinoma 9, large cell carcinoma 9, squamous cell carcinoma 6, small cell carcinoma 6) and five other cell lines (colon carcinoma 2, melanoma 1, teratocarcinoma 1, thymoma 1)."7.70Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells. ( Fujimura, S; Hasumi, T; Kobayashi, S; Okada, S; Sato, N, 1998)
" with NC carcinoma were treated with 16,16-dimethyl prostaglandin E2 methyl ester (di-me-PGE2) and/or indomethacin."7.67Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin. ( Bennett, A; Carroll, MA; Melhuish, PB; Stamford, IF, 1985)
" Here, we show that baicalein (selective 12-lipoxygenase inhibitor), nordihydroguaiaretic acid (non-selective lipoxygenase inhibitor), and indomethacin (non-selective cyclooxygenase inhibitor) are cytotoxic to Ehrlich carcinoma cells in vitro."3.96α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors. ( Balashevich, T; Osipov, AV; Terpinskaya, TI; Tsetlin, VI; Utkin, YN; Yanchanka, T; Zhmak, MN, 2020)
" In AMC-HN5 human sinonasal carcinoma cells, indomethacin was the most potent NAG-1 inducer and caused NAG-1 expression in a time- and dose-dependent manner."3.74Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. ( Chang, JH; Cho, CI; Jeon, JH; Kim, JH; Kim, KS; Kwon, SH; Lee, KW; Rhee, KH; Song, K; Yoon, JH, 2008)
"The modulating activity of indomethacin to vincristine (VCR) was investigated in thirty human pulmonary carcinoma cell lines (adenocarcinoma 9, large cell carcinoma 9, squamous cell carcinoma 6, small cell carcinoma 6) and five other cell lines (colon carcinoma 2, melanoma 1, teratocarcinoma 1, thymoma 1)."3.70Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells. ( Fujimura, S; Hasumi, T; Kobayashi, S; Okada, S; Sato, N, 1998)
"Irradiated tumor cells given, together with indomethacin, to syngeneic mice induced an antitumor response and conferred protection against a challenge of a lethal dose of murine mammary (4T1) and lung (3LL) carcinoma cells."3.70Induction of antitumor immunity by indomethacin. ( Gelfand, Y; Morecki, S; Shohami, E; Slavin, S; Trembovler, V; Yacovlev, E, 2000)
" The effect of folate on the interaction between methotrexate (a folate analogue) and indomethacin has been examined in murine NC carcinoma cells."3.69The effect of folate on the methotrexate/indomethacin interaction in a murine cancer cell line. ( Anderson, EM; Bennett, A; Hollingsworth, SJ, 1995)
"Indomethacine, protamine-sulphate and hydrocortisone were found to decrease the activity of metastatic processes of Lewis carcinoma after the removal of the primary tumour."3.67[Effect of actions inhibiting neovascularization of the metastasis of Lewis lung carcinoma]. ( Balitskiĭ, KP; Lisniak, IA; Sopotsinskaia, EB, 1985)
"The histamine-2 receptor antagonist cimetidine (10(-5)M) and the prostaglandin synthesis inhibitor indomethacin (10(-8)M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma."3.67Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. ( Flodgren, P; Sjögren, HO, 1985)
" No statistically significant difference in delayed hypersensitivity response to dinitrochlorobenzene was found between indomethacin-treated, tumor-bearing and control groups."3.67Indomethacin and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in the hamster buccal pouch. ( Gould, AR; Grant, FT; Miller, RL; Perry, DA, 1985)
" with NC carcinoma were treated with 16,16-dimethyl prostaglandin E2 methyl ester (di-me-PGE2) and/or indomethacin."3.67Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin. ( Bennett, A; Carroll, MA; Melhuish, PB; Stamford, IF, 1985)
"LADG for early gastric cancer is a feasible and safe procedure with short-term clinical results superior to those of ODG."2.78Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial. ( Bax, L; Futawatari, N; Katada, N; Kikuchi, S; Okutomi, T; Sakuramoto, S; Wang, G; Watanabe, M; Yamashita, K, 2013)
"Relapse of castration-resistant prostate cancer (CRPC) that occurs after androgen deprivation therapy of primary prostate cancer can be mediated by reactivation of the androgen receptor (AR)."1.37Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. ( Balk, SP; Bubley, GJ; Cai, C; Chen, S; Marck, B; Matsumoto, AM; Mostaghel, EA; Nelson, PS; Ng, P; Simon, NI; Wang, H, 2011)
"An animal model of cancer pain induced by injection of Walker 256 carcinoma cells into the plantar surface of rat hind paw is described."1.34Walker 256 tumor-bearing rats as a model to study cancer pain. ( Brigatte, P; Curi, R; Cury, Y; Guerra, JL; Gutierrez, VP; Sampaio, SC; Sinhorini, IL, 2007)
" Chronic administration of indomethacin in the drinking water at 10 micrograms/ml potentiated the MVE-5 antitumor induced macrophage activation in vivo."1.27Potentiation of nonspecific immunotherapy of experimental lung metastases by indomethacin. ( Altom, MG; Schultz, RM, 1983)
"The production of bone resorption-stimulating activity and PGE2 by VX2 cells in culture were both inhibited by indomethacin (100 ng/ml)."1.25Hypercalcemia and tumor-prostaglandins: the VX2 carcinoma model in the rabbit. ( Franklin, R; Levine, L; Tashjian, AH; Voelkel, EF; Wasserman, E, 1975)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199020 (52.63)18.7374
1990's6 (15.79)18.2507
2000's7 (18.42)29.6817
2010's4 (10.53)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Osipov, AV1
Terpinskaya, TI1
Yanchanka, T1
Balashevich, T1
Zhmak, MN1
Tsetlin, VI1
Utkin, YN1
Chiou, SK1
Hoa, N1
Hodges, A1
Ge, L1
Jadus, MR1
Cai, C1
Chen, S2
Ng, P1
Bubley, GJ1
Nelson, PS1
Mostaghel, EA1
Marck, B1
Matsumoto, AM1
Simon, NI1
Wang, H1
Balk, SP1
Lönnroth, C1
Andersson, M1
Nordgren, S1
Lundholm, K1
Sakuramoto, S1
Yamashita, K1
Kikuchi, S1
Futawatari, N1
Katada, N1
Watanabe, M1
Okutomi, T1
Wang, G1
Bax, L1
Roh, JL1
Sung, MW1
Kim, KH1
Kobayashi, S2
Nantz, R1
Kitamura, T1
Higashikubo, R1
Horikoshi, N1
Yoshii, M1
Jikuhara, A1
Mori, S1
Iwagaki, H1
Takahashi, HK1
Nishibori, M1
Tanaka, N1
Brigatte, P1
Sampaio, SC1
Gutierrez, VP1
Guerra, JL1
Sinhorini, IL1
Curi, R1
Cury, Y1
Kim, JH1
Chang, JH1
Rhee, KH1
Yoon, JH1
Kwon, SH1
Song, K1
Lee, KW1
Cho, CI1
Jeon, JH1
Kim, KS1
Doppelt, SH1
Slovik, DM1
Neer, RM1
Nolan, J1
Zusman, RM1
Potts, JT1
Schultz, RM1
Altom, MG1
Hagiwara, M1
McNamara, DB1
Chen, IL1
Fisher, JW1
Han, T1
Takita, H1
Panje, WR1
Buick, RN1
Fry, SE1
Salmon, SE1
Hollingsworth, SJ1
Anderson, EM1
Bennett, A2
Meng, CL1
Yang, CY1
Shen, KL1
Wong, PY1
Lee, HK1
Okada, S1
Hasumi, T1
Sato, N1
Fujimura, S1
Morecki, S1
Yacovlev, E1
Gelfand, Y1
Trembovler, V1
Shohami, E1
Slavin, S1
Boström, PJ1
Aaltonen, V1
Söderström, KO1
Uotila, P1
Laato, M1
Voelkel, EF2
Levine, L2
Alper, CA1
Tashjian, AH2
Franklin, R1
Wasserman, E1
Rahal, MD1
Reinish, E1
Osmond, DG1
Aliño, SF1
Unda, FJ1
Iruarrizaga, A1
Alfaro, J1
Hilario, E1
Pérez-Yarza, G1
Bobadilla, M1
Lejarreta, M1
Fariñas, MC1
Rodriguez-Valverde, V1
Zarrabeitia, MT1
Parra-Blanco, JA1
Sanz-Ortiz, J1
Sopotsinskaia, EB1
Lisniak, IA1
Balitskiĭ, KP1
Karczag, E2
Minárovits, J2
Földes, I2
Yron, I1
Schickler, M1
Fisch, B1
Pinkas, H1
Ovadia, J1
Witz, IP1
Young, MR1
Endicott, RA1
Duffie, GP1
Wepsic, HT1
Flodgren, P1
Sjögren, HO1
Yoneda, T1
Kitamura, M1
Ogawa, T1
Aya, S1
Sakuda, M1
Gould, AR1
Miller, RL1
Grant, FT1
Perry, DA1
Carroll, MA1
Melhuish, PB1
Stamford, IF1
Thomas, DR1
Philpott, GW1
Jaffe, BM3
Cohen, F1

Reviews

1 review available for indomethacin and Carcinoma, Anaplastic

ArticleYear
Prostaglandins and cancer: an update.
    Prostaglandins, 1974, Jun-25, Volume: 6, Issue:6

    Topics: Animals; Aspirin; Bucladesine; Calcium; Carcinoma; Cell Division; Cell Line; Depression, Chemical; H

1974

Trials

1 trial available for indomethacin and Carcinoma, Anaplastic

ArticleYear
Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial.
    Surgical endoscopy, 2013, Volume: 27, Issue:5

    Topics: Administration, Rectal; Aged; Analgesia, Patient-Controlled; Analgesics; Carcinoma; Comorbidity; Cri

2013

Other Studies

36 other studies available for indomethacin and Carcinoma, Anaplastic

ArticleYear
α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors.
    Marine drugs, 2020, Apr-07, Volume: 18, Issue:4

    Topics: Animals; Arachidonic Acid; Carcinoma; Carcinoma, Ehrlich Tumor; Cell Survival; Cobra Neurotoxin Prot

2020
Indomethacin promotes apoptosis in gastric cancer cells through concomitant degradation of Survivin and Aurora B kinase proteins.
    Apoptosis : an international journal on programmed cell death, 2014, Volume: 19, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Aurora Kinase

2014
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.
    Cancer research, 2011, Oct-15, Volume: 71, Issue:20

    Topics: Androstenedione; Androstenes; Androstenols; Animals; Antineoplastic Agents, Hormonal; Carcinoma; Cel

2011
Downregulation of Prominin 1/CD133 expression in colorectal cancer by NSAIDs following short-term preoperative treatment.
    International journal of oncology, 2012, Volume: 41, Issue:1

    Topics: AC133 Antigen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Bioma

2012
Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin.
    Head & neck, 2005, Volume: 27, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Carcinoma, Squamous Cell; Celecoxib; Ce

2005
Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation.
    Oncogene, 2005, Apr-21, Volume: 24, Issue:18

    Topics: Carcinoma; Colonic Neoplasms; DNA Replication; Extracellular Signal-Regulated MAP Kinases; HeLa Cell

2005
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
    Journal of pharmacological sciences, 2005, Volume: 98, Issue:4

    Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxyg

2005
Walker 256 tumor-bearing rats as a model to study cancer pain.
    The journal of pain, 2007, Volume: 8, Issue:5

    Topics: Animals; Carcinoma; Cell Line, Tumor; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethaci

2007
Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene.
    International journal of cancer, 2008, Apr-15, Volume: 122, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Blotting, Wester

2008
Gut-mediated hypercalcemia in rabbits bearing VX2 carcinoma: new mechanism for tumor-induced hypercalcemia.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:2

    Topics: Animals; Carcinoma; Clodronic Acid; Hypercalcemia; Indomethacin; Male; Neoplasms, Experimental; Pros

1982
Potentiation of nonspecific immunotherapy of experimental lung metastases by indomethacin.
    Journal of immunopharmacology, 1983, Volume: 5, Issue:4

    Topics: Animals; Carcinoma; Cyclooxygenase Inhibitors; Drug Synergism; Immunotherapy; Indomethacin; Lung Neo

1983
Role of endogenous prostaglandin E2 in erythropoietin production and dome formation by human renal carcinoma cells in culture.
    The Journal of clinical investigation, 1984, Volume: 74, Issue:4

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinoma; Cell Transformation, Neoplastic; Cells, Cul

1984
Indomethacin-mediated enhancement of lymphocyte response to mitogens in healthy subjects and lung cancer patients.
    Cancer, 1980, Dec-01, Volume: 46, Issue:11

    Topics: Adult; Aged; Carcinoma; Concanavalin A; Dose-Response Relationship, Drug; Female; Humans; Indomethac

1980
Regression of head and neck carcinoma with a prostaglandin-synthesis inhibitor.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1981, Volume: 107, Issue:11

    Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Head and N

1981
Effect of host-cell interactions on clonogenic carcinoma cells in human malignant effusions.
    British journal of cancer, 1980, Volume: 41, Issue:5

    Topics: Ascitic Fluid; Carcinoma; Cell Adhesion; Cell Count; Cell Fractionation; Clone Cells; Female; Hemato

1980
The effect of folate on the methotrexate/indomethacin interaction in a murine cancer cell line.
    British journal of pharmacology, 1995, Volume: 116, Issue:2

    Topics: Animals; Carcinoma; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Folic Acid; Indo

1995
Inhibition of the synthesis of eicosanoid-like substances in a human oral cancer cell line by interferon-gamma and eicosapentaenoic acid.
    Archives of oral biology, 1998, Volume: 43, Issue:12

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Analysis of Variance; Arachidonic Acids; Carcinoma; Chromatography,

1998
Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells.
    The Tohoku journal of experimental medicine, 1998, Volume: 186, Issue:4

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Carcinoma;

1998
Induction of antitumor immunity by indomethacin.
    Cancer immunology, immunotherapy : CII, 2000, Volume: 48, Issue:11

    Topics: Adjuvants, Immunologic; Animals; Cancer Vaccines; Carcinoma; Cyclooxygenase Inhibitors; Cytotoxicity

2000
Expression of cyclooxygenase-1 and -2 in urinary bladder carcinomas in vivo and in vitro and prostaglandin E2 synthesis in cultured bladder cancer cells.
    Pathology, 2001, Volume: 33, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Re

2001
Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2 carcinoma.
    The Journal of experimental medicine, 1978, Apr-01, Volume: 147, Issue:4

    Topics: Animals; Carcinoma; Ceruloplasmin; Female; Haptoglobins; Indomethacin; Neoplasms, Experimental; Pros

1978
Hypercalcemia and tumor-prostaglandins: the VX2 carcinoma model in the rabbit.
    Metabolism: clinical and experimental, 1975, Volume: 24, Issue:8

    Topics: Animals; Biological Assay; Bone Resorption; Carcinoma; Disease Models, Animal; Femoral Vein; Hyperca

1975
Changes in the populations of null, NK1.1+, and Thy1lo lymphocytes in the bone marrow of tumor-bearing mice: effect of indomethacin treatment.
    Cellular immunology, 1992, Volume: 139, Issue:1

    Topics: Animals; Antigens, Surface; Bone Marrow; Carcinoma; Carcinoma, Ehrlich Tumor; Indomethacin; Killer C

1992
Efficacy of liposome-encapsulated indomethacin in response against metastatic 3LL and B16F1 tumor cells.
    Laboratory investigation; a journal of technical methods and pathology, 1992, Volume: 66, Issue:6

    Topics: Animals; Carcinoma; Chromatography, High Pressure Liquid; Dinoprostone; Drug Carriers; Indomethacin;

1992
Contribution of monocytes to the decreased lymphoproliferative response to phytohemagglutinin in patients with lung cancer.
    Cancer, 1991, Sep-15, Volume: 68, Issue:6

    Topics: Adenocarcinoma; Aged; Carcinoma; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; Int

1991
[Effect of actions inhibiting neovascularization of the metastasis of Lewis lung carcinoma].
    Eksperimental'naia onkologiia, 1985, Volume: 7, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Drug Evaluation, Preclinical; Hy

1985
Comparison of the effects of peritoneal and spleen cells of syngeneic or allogeneic origin on the take of transplantable murine tumours.
    Acta microbiologica Hungarica, 1989, Volume: 36, Issue:1

    Topics: Acenocoumarol; Adenocarcinoma; Animals; Carcinoma; Indomethacin; Mice; Mice, Inbred BALB C; Mice, In

1989
Characterization of activated peritoneal cells inhibiting the take of transplantable murine tumours.
    Acta microbiologica Hungarica, 1989, Volume: 36, Issue:1

    Topics: Acenocoumarol; Adenocarcinoma; Animals; Antibodies; Carcinoma; Complement System Proteins; Female; G

1989
The immune system during the pre-cancer and the early cancer period. IL-2 production by PBL from post-menopausal women with and without endometrial carcinoma.
    International journal of cancer, 1986, Sep-15, Volume: 38, Issue:3

    Topics: B-Lymphocytes; Carcinoma; Female; Humans; Indomethacin; Interleukin-2; Lymphocyte Activation; Macrop

1986
Suppressor alveolar macrophages in mice bearing metastatic Lewis lung carcinoma tumors.
    Journal of leukocyte biology, 1987, Volume: 42, Issue:6

    Topics: Animals; Antioxidants; Carcinoma; Female; Immune Tolerance; Indomethacin; Killer Cells, Natural; Lun

1987
Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.
    Cancer immunology, immunotherapy : CII, 1985, Volume: 19, Issue:1

    Topics: Antibody-Dependent Cell Cytotoxicity; Carcinoma; Cimetidine; Colonic Neoplasms; Cytotoxicity, Immuno

1985
Control of VX2 carcinoma cell growth in culture by calcium, calmodulin, and prostaglandins.
    Cancer research, 1985, Volume: 45, Issue:1

    Topics: Animals; Bone Resorption; Calcimycin; Calcium; Calmodulin; Carcinoma; Cell Division; Cell Line; DNA

1985
Indomethacin and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in the hamster buccal pouch.
    Journal of oral pathology, 1985, Volume: 14, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cheek; Cricetinae; Dinitrochlorobenzene; Drug

1985
Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin.
    British journal of cancer, 1985, Volume: 52, Issue:2

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Carcinoma; Indomethacin; Male; Mice; Mice, Inbred Strains;

1985
The relationship between concentration of prostaglandin E and rates of cell replication.
    Experimental cell research, 1974, Mar-15, Volume: 84, Issue:1

    Topics: Animals; Bucladesine; Carcinoma; Cell Division; Cell Line; Depression, Chemical; Female; HeLa Cells;

1974
Production of prostaglandins by cells in vitro: radioimmunoassay measurement of the conversion of arachidonic acid to PGE2 and PGF2 alpha.
    Biochemical and biophysical research communications, 1973, Dec-10, Volume: 55, Issue:3

    Topics: Animals; Arachidonic Acids; Carcinoma; Cell Line; Colon; Gastric Mucosa; HeLa Cells; Humans; Indomet

1973