indomethacin has been researched along with Cancer of Skin in 45 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because of the additive antitumor effects of interleukin 1 alpha (IL-1 alpha) and indomethacin in vivo, we conducted a phase II trial of this combination in patients with melanoma." | 9.08 | Phase II trial of interleukin 1 alpha and indomethacin in treatment of metastatic melanoma. ( Alvord, WG; Beauchamp, AE; Conlon, KC; Creekmore, SP; Curti, BD; Fenton, RG; Gause, BL; Holmlund, JT; Janik, JE; Kopp, WC; Longo, DL; Miller, LL; Oppenheim, JJ; Powers, GC; Sharfman, WH; Smith, JW; Steis, RG; Sznol, M; Urba, WJ, 1996) |
| "As a result of preclinical data demonstrating the antitumour and antimetastatic efficiency of indomethacin in murine models, and the clinical observation of occasional tumour regression in patients with advanced melanoma treated with indomethacin together with ranitidine, a Phase II study was performed of prolonged administration of these two oral agents in combination." | 9.08 | Oral indomethacin and ranitidine in advanced melanoma: a phase II study. ( Lohmann, RC; Mertens, WC, 1996) |
| "Skin metastasis of malignant melanoma has been difficult to control by chemoimmunotherapy." | 5.27 | [Control of multiple skin and lung metastasis of malignant melanoma by combined DAV and OK-432 chemoimmunotherapy in association with large-scale administration of indomethacin]. ( Jimbow, K; Kawamura, M; Maeda, K; Miura, S, 1984) |
| "Because of the additive antitumor effects of interleukin 1 alpha (IL-1 alpha) and indomethacin in vivo, we conducted a phase II trial of this combination in patients with melanoma." | 5.08 | Phase II trial of interleukin 1 alpha and indomethacin in treatment of metastatic melanoma. ( Alvord, WG; Beauchamp, AE; Conlon, KC; Creekmore, SP; Curti, BD; Fenton, RG; Gause, BL; Holmlund, JT; Janik, JE; Kopp, WC; Longo, DL; Miller, LL; Oppenheim, JJ; Powers, GC; Sharfman, WH; Smith, JW; Steis, RG; Sznol, M; Urba, WJ, 1996) |
| "As a result of preclinical data demonstrating the antitumour and antimetastatic efficiency of indomethacin in murine models, and the clinical observation of occasional tumour regression in patients with advanced melanoma treated with indomethacin together with ranitidine, a Phase II study was performed of prolonged administration of these two oral agents in combination." | 5.08 | Oral indomethacin and ranitidine in advanced melanoma: a phase II study. ( Lohmann, RC; Mertens, WC, 1996) |
| "Orally administered indomethacin at 10-600 micrograms per mouse per day has been shown to inhibit UV radiation-induced erythema dose responsively." | 3.69 | The protective effect of indomethacin on photocarcinogenesis in hairless mice. ( Boehm-Wilcox, C; Bosnic, M; Matheson, MJ; Reeve, VE, 1995) |
| " As determined by Toxilight-cytotoxicity assay, the drug was only toxic to the cancer cells at 100 microM." | 1.33 | Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. ( Chiu, LC; Ooi, VE; Tong, KF, 2005) |
| "Indomethacin was found to delay the onset and reduce the size of tumours in BP- but not DMBA-treated mice." | 1.28 | A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice. ( Andrews, J; Halliday, GM; Muller, HK, 1991) |
| "Skin metastasis of malignant melanoma has been difficult to control by chemoimmunotherapy." | 1.27 | [Control of multiple skin and lung metastasis of malignant melanoma by combined DAV and OK-432 chemoimmunotherapy in association with large-scale administration of indomethacin]. ( Jimbow, K; Kawamura, M; Maeda, K; Miura, S, 1984) |
| "Indomethacin was found to inhibit TPA-induced ornithine decarboxylase activity to the same extent in both mice." | 1.27 | Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: a comparison between SENCAR and NMRI mice. ( Fischer, SM; Fürstenberger, G; Marks, F; Slaga, TJ, 1987) |
| "Indomethacin is a nonsteroidal antiinflammatory agent which may act by inhibiting prostaglandin biosynthesis." | 1.26 | Inhibition of ultraviolet-B epidermal ornithine decarboxylase induction and skin carcinogenesis in hairless mice by topical indomethacin and triamcinolone acetonide. ( Breeding, J; Chalet, M; Connor, MJ; Lowe, NJ, 1982) |
| "Flurbiprofen was also observed to enhance promotion slightly." | 1.26 | Indomethacin enhancement of TPA tumor promotion in mice. ( Fischer, SM; Gleason, GL; Mills, GD; Slaga, TJ, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (48.89) | 18.7374 |
| 1990's | 16 (35.56) | 18.2507 |
| 2000's | 3 (6.67) | 29.6817 |
| 2010's | 4 (8.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Motohashi, S | 1 |
| Akihisa, T | 1 |
| Tamura, T | 1 |
| Tokutake, N | 1 |
| Takido, M | 1 |
| Yasukawa, K | 2 |
| Tse, AK | 1 |
| Cao, HH | 1 |
| Cheng, CY | 1 |
| Kwan, HY | 1 |
| Yu, H | 1 |
| Fong, WF | 1 |
| Yu, ZL | 1 |
| Prasad, R | 1 |
| Katiyar, SK | 1 |
| Somasundaram, R | 1 |
| Herlyn, M | 1 |
| Patel, T | 1 |
| Kirsner, RS | 1 |
| Iida, T | 1 |
| Fujimoto, Y | 1 |
| Park, WH | 1 |
| Joo, ST | 1 |
| Park, KK | 1 |
| Chang, YC | 1 |
| Kim, CH | 1 |
| Chiu, LC | 1 |
| Tong, KF | 1 |
| Ooi, VE | 1 |
| Tobia, L | 1 |
| Al-Salem, T | 1 |
| Ali, ZS | 1 |
| Qassab, M | 1 |
| Minassian, AA | 1 |
| Kadagidze, ZG | 1 |
| Verma, AK | 6 |
| Ashendel, CL | 3 |
| Boutwell, RK | 6 |
| Fürstenberger, G | 4 |
| Richter, H | 2 |
| Argyris, TS | 1 |
| Marks, F | 4 |
| Maeda, K | 1 |
| Miura, S | 1 |
| Kawamura, M | 1 |
| Jimbow, K | 1 |
| Takenaga, K | 1 |
| Hozumi, M | 1 |
| Astrup, E | 1 |
| Berry, DL | 1 |
| Bertsch, S | 1 |
| Lowe, NJ | 1 |
| Connor, MJ | 1 |
| Breeding, J | 1 |
| Chalet, M | 1 |
| Fischer, SM | 5 |
| Gleason, GL | 2 |
| Bohrman, JS | 1 |
| Slaga, TJ | 4 |
| Mills, GD | 1 |
| Reeve, VE | 1 |
| Matheson, MJ | 1 |
| Bosnic, M | 1 |
| Boehm-Wilcox, C | 1 |
| Haedersdal, M | 1 |
| Poulsen, T | 1 |
| Wulf, HC | 1 |
| Kudriavtsev, IA | 1 |
| Miasishcheva, NV | 1 |
| Jiang, H | 1 |
| Yamamoto, S | 1 |
| Kato, R | 1 |
| Kochevar, IE | 1 |
| Moran, M | 1 |
| Lyon, N | 1 |
| Flotte, T | 1 |
| Siebert, E | 1 |
| Gange, RW | 1 |
| Kiriyama, T | 1 |
| Gillespie, MT | 1 |
| Glatz, JA | 1 |
| Fukumoto, S | 1 |
| Moseley, JM | 1 |
| Martin, TJ | 1 |
| Janik, JE | 1 |
| Miller, LL | 1 |
| Longo, DL | 1 |
| Powers, GC | 1 |
| Urba, WJ | 1 |
| Kopp, WC | 1 |
| Gause, BL | 1 |
| Curti, BD | 1 |
| Fenton, RG | 1 |
| Oppenheim, JJ | 1 |
| Conlon, KC | 1 |
| Holmlund, JT | 1 |
| Sznol, M | 1 |
| Sharfman, WH | 1 |
| Steis, RG | 1 |
| Creekmore, SP | 1 |
| Alvord, WG | 1 |
| Beauchamp, AE | 1 |
| Smith, JW | 1 |
| Mertens, WC | 1 |
| Lohmann, RC | 1 |
| Lo, HH | 1 |
| Gordon, GB | 1 |
| Seibert, K | 1 |
| Kelloff, G | 1 |
| Lubet, RA | 1 |
| Conti, CJ | 1 |
| O'Brien, TG | 1 |
| Weekes, RG | 1 |
| DeYoung, LM | 1 |
| Astrup, EG | 1 |
| Goerttler, K | 1 |
| Edler, L | 1 |
| Loehrke, H | 1 |
| Mentz, P | 1 |
| Giessler, C | 1 |
| Andrews, J | 1 |
| Halliday, GM | 1 |
| Muller, HK | 1 |
| Patrick, KE | 1 |
| Patamalai, B | 1 |
| Faradzhev, ZG | 3 |
| Mazina, NM | 1 |
| Ivshina, AV | 1 |
| Ishihara, K | 1 |
| al-Waili, NS | 1 |
| Samsonov, VA | 1 |
| Bassalyk, LS | 1 |
| Nemtsova, MP | 1 |
| Gross, M | 1 |
| Loprinzi, CL | 2 |
| Carbone, PP | 1 |
1 review available for indomethacin and Cancer of Skin
| Article | Year |
|---|---|
Mouse skin: a useful model system for studying the mechanism of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Carcinogens; Cell Communication; Cell | 1982 |
2 trials available for indomethacin and Cancer of Skin
| Article | Year |
|---|---|
Phase II trial of interleukin 1 alpha and indomethacin in treatment of metastatic melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chi-Square Distribution; Female; HLA-B | 1996 |
Oral indomethacin and ranitidine in advanced melanoma: a phase II study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antin | 1996 |
42 other studies available for indomethacin and Cancer of Skin
| Article | Year |
|---|---|
Alkane-6,8-diol: inhibitor of tumor promotion in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Fa | 1995 |
Indomethacin sensitizes TRAIL-resistant melanoma cells to TRAIL-induced apoptosis through ROS-mediated upregulation of death receptor 5 and downregulation of survivin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line, Tumor; Down-Regulation; Drug Resistan | 2014 |
Ultraviolet radiation-induced inflammation activates β-catenin signaling in mouse skin and skin tumors.
Topics: Animals; beta Catenin; Casein Kinase I; Cyclin D1; Cyclin D2; Cyclooxygenase 2; Cyclooxygenase 2 Inh | 2014 |
Indomethacin to the rescue of TRAIL-resistant melanomas.
Topics: Humans; Indomethacin; Inhibitor of Apoptosis Proteins; Melanoma; Receptors, TNF-Related Apoptosis-In | 2014 |
JID VisualDx quiz: May 2014.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Melanoma; Skin Neoplasms | 2014 |
Relative inhibitory activity of bile acids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, and chenodeoxycholic acid inhibition of tumour promotion in mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Bile A | 2009 |
Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Hepat | 2004 |
Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells.
Topics: Antineoplastic Agents; Aspirin; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Cyclooxygen | 2005 |
[The therapeutic problem of cutaneous photosensitization. Considerations on a case of xeroderma pigmentosum].
Topics: Adolescent; Carcinoma, Basal Cell; Female; Humans; Indomethacin; Photosensitivity Disorders; Skin Ne | 1967 |
Skin cancers in xeroderma pigmentosum: response to indomethacin and steroids.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Indomethacin; | 1980 |
Suppressor cells in melanoma and lung cancer: correlation with the clinical stage.
Topics: Adult; Aged; Humans; Indomethacin; Lung Neoplasms; Melanoma; Middle Aged; Neoplasm Staging; Phytohem | 1983 |
Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Carboxy-Lyases; Cyclooxygenase Inhibitors; Female; Ind | 1980 |
Effects of the phorbol ester 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo: evidence for its uselessness as a negative control compound in studies on the biological effects of phorbol ester tumor promoters.
Topics: Animals; Cell Division; Cocarcinogenesis; Cyclic AMP; Epidermis; Female; Growth Inhibitors; Indometh | 1982 |
On the role of tumour promotion in chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dexamethasone; DNA Replication; Hyperplasia; | 1984 |
[Control of multiple skin and lung metastasis of malignant melanoma by combined DAV and OK-432 chemoimmunotherapy in association with large-scale administration of indomethacin].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Humans; Indomethacin; Lung Neopla | 1984 |
[Cellular actions of inhibitors of chemical carcinogenesis: modifications of syntheses of prostaglandins and differentiation of myeloid leukemia cells].
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Dexamethasone; Humans; Indomethacin; Leukem | 1983 |
On the relationship between epidermal hyperproliferation and skin tumor promotion.
Topics: Calcimycin; Cell Division; Cocarcinogenesis; Dinoprost; Dinoprostone; Epidermal Cells; Hyperplasia; | 1982 |
Inhibition of ultraviolet-B epidermal ornithine decarboxylase induction and skin carcinogenesis in hairless mice by topical indomethacin and triamcinolone acetonide.
Topics: Animals; Carboxy-Lyases; Carcinogens; Enzyme Induction; Female; Indomethacin; Mice; Mice, Mutant Str | 1982 |
Prostaglandin enhancement of skin tumor initiation and promotion.
Topics: Animals; Indomethacin; Mice; Neoplasms, Experimental; Phorbols; Prostaglandins; Prostaglandins E; Pr | 1980 |
An organ culture of adult mouse skin: an in vitro model for studying the molecular mechanism of skin tumor promotion.
Topics: Animals; Carboxy-Lyases; DNA; Enzyme Induction; Female; Indomethacin; Mice; Models, Biological; Neop | 1980 |
Indomethacin enhancement of TPA tumor promotion in mice.
Topics: Animals; Drug Synergism; Female; Flurbiprofen; Indomethacin; Mice; Neoplasms, Experimental; Papillom | 1980 |
The protective effect of indomethacin on photocarcinogenesis in hairless mice.
Topics: Animals; Carcinoma, Squamous Cell; Diet; Erythema; Female; Indomethacin; Mice; Mice, Hairless; Neopl | 1995 |
Effects of systemic indomethacin on photocarcinogenesis in hairless mice.
Topics: Animals; DNA Damage; Female; Indomethacin; Mice; Mice, Hairless; Mice, Inbred C3H; Skin Neoplasms; U | 1995 |
[Synthesis of arachidonic acid cascade eicosanoids in tumors of various histogenesis in mice].
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenocarcinoma; Animals; Arachidonic Acid; Carcinoma, Le | 1995 |
Inhibition of two-stage skin carcinogenesis as well as complete skin carcinogenesis by oral administration of TMK688, a potent lipoxygenase inhibitor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Anticarcin | 1994 |
Effects of systemic indomethacin, meclizine, and BW755C on chronic ultraviolet B-induced effects in hairless mouse skin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Fem | 1993 |
Transforming growth factor beta stimulation of parathyroid hormone-related protein (PTHrP): a paracrine regulator?
Topics: Base Sequence; Carcinoma, Squamous Cell; Culture Media, Conditioned; Gene Expression Regulation, Neo | 1993 |
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Celecoxib; Cell Division; Cyclooxygen | 1999 |
The induction of ornithine decarboxylase activity and its control in mouse skin epidermis.
Topics: Adenosylmethionine Decarboxylase; Alkaloids; Amines; Animals; Carboxy-Lyases; Enzyme Induction; Epid | 1978 |
Long term tumorigenicity of a single application of indomethacin or Amuno in adolescent and in adult male Sprague Dawley rats.
Topics: Aging; Animals; Body Weight; Epidermis; Hyperplasia; Indomethacin; Leydig Cell Tumor; Liver Neoplasm | 1992 |
Biosynthesis of TXB2 and 6-oxo-PGF1 alpha in the heart and other tissues under pathophysiological conditions.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aqueous Humor; Brain Diseases; Child; Gastric Mucosa; Gastrit | 1992 |
A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Presenti | 1991 |
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capillary Permeability; Cimetidine; Diphenhydramine; Fema | 1990 |
[The functioning of the interferon system in mycosis fungoides patients undergoing different methods of therapy].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chronic Disease; Drug Evalu | 1990 |
[The effect of therapy on the immunological indices in patients with skin lymphomas and Kaposi's sarcoma].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chronic Disease; Humans; In | 1990 |
[Therapeutic response of interferon-beta in malignant melanoma].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Female; Humans; | 1986 |
Indomethacin in basal cell carcinoma.
Topics: Carcinoma, Basal Cell; Female; Humans; Indomethacin; Middle Aged; Prostaglandins; Skin Neoplasms | 1989 |
[The effectiveness of treating patients with malignant skin lymphoma and Kaposi's sarcoma studied via polyamines].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chronic Disease; Drug Evalu | 1989 |
Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion).
Topics: Animals; Cocarcinogenesis; Dinoprost; Dinoprostone; Epidermis; Indomethacin; Mice; Papilloma; Phorbo | 1989 |
Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: a comparison between SENCAR and NMRI mice.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; DNA Rep | 1987 |
Inhibition of phorbol ester--induced human epidermal ornithine decarboxylase activity by oral compounds: a possible role in human chemoprevention studies.
Topics: Adult; Cells, Cultured; Enzyme Induction; Female; Humans; Indomethacin; Isotretinoin; Male; Ornithin | 1985 |
Dose and schedule of oral retinoic acid and indomethacin needed to effectively inhibit phorbol ester-induced epidermal ornithine decarboxylase activity.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Femal | 1985 |