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indomethacin and Cancer of Skin

indomethacin has been researched along with Cancer of Skin in 45 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"Because of the additive antitumor effects of interleukin 1 alpha (IL-1 alpha) and indomethacin in vivo, we conducted a phase II trial of this combination in patients with melanoma."9.08Phase II trial of interleukin 1 alpha and indomethacin in treatment of metastatic melanoma. ( Alvord, WG; Beauchamp, AE; Conlon, KC; Creekmore, SP; Curti, BD; Fenton, RG; Gause, BL; Holmlund, JT; Janik, JE; Kopp, WC; Longo, DL; Miller, LL; Oppenheim, JJ; Powers, GC; Sharfman, WH; Smith, JW; Steis, RG; Sznol, M; Urba, WJ, 1996)
"As a result of preclinical data demonstrating the antitumour and antimetastatic efficiency of indomethacin in murine models, and the clinical observation of occasional tumour regression in patients with advanced melanoma treated with indomethacin together with ranitidine, a Phase II study was performed of prolonged administration of these two oral agents in combination."9.08Oral indomethacin and ranitidine in advanced melanoma: a phase II study. ( Lohmann, RC; Mertens, WC, 1996)
"Skin metastasis of malignant melanoma has been difficult to control by chemoimmunotherapy."5.27[Control of multiple skin and lung metastasis of malignant melanoma by combined DAV and OK-432 chemoimmunotherapy in association with large-scale administration of indomethacin]. ( Jimbow, K; Kawamura, M; Maeda, K; Miura, S, 1984)
"Because of the additive antitumor effects of interleukin 1 alpha (IL-1 alpha) and indomethacin in vivo, we conducted a phase II trial of this combination in patients with melanoma."5.08Phase II trial of interleukin 1 alpha and indomethacin in treatment of metastatic melanoma. ( Alvord, WG; Beauchamp, AE; Conlon, KC; Creekmore, SP; Curti, BD; Fenton, RG; Gause, BL; Holmlund, JT; Janik, JE; Kopp, WC; Longo, DL; Miller, LL; Oppenheim, JJ; Powers, GC; Sharfman, WH; Smith, JW; Steis, RG; Sznol, M; Urba, WJ, 1996)
"As a result of preclinical data demonstrating the antitumour and antimetastatic efficiency of indomethacin in murine models, and the clinical observation of occasional tumour regression in patients with advanced melanoma treated with indomethacin together with ranitidine, a Phase II study was performed of prolonged administration of these two oral agents in combination."5.08Oral indomethacin and ranitidine in advanced melanoma: a phase II study. ( Lohmann, RC; Mertens, WC, 1996)
"Orally administered indomethacin at 10-600 micrograms per mouse per day has been shown to inhibit UV radiation-induced erythema dose responsively."3.69The protective effect of indomethacin on photocarcinogenesis in hairless mice. ( Boehm-Wilcox, C; Bosnic, M; Matheson, MJ; Reeve, VE, 1995)
" As determined by Toxilight-cytotoxicity assay, the drug was only toxic to the cancer cells at 100 microM."1.33Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. ( Chiu, LC; Ooi, VE; Tong, KF, 2005)
"Indomethacin was found to delay the onset and reduce the size of tumours in BP- but not DMBA-treated mice."1.28A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice. ( Andrews, J; Halliday, GM; Muller, HK, 1991)
"Skin metastasis of malignant melanoma has been difficult to control by chemoimmunotherapy."1.27[Control of multiple skin and lung metastasis of malignant melanoma by combined DAV and OK-432 chemoimmunotherapy in association with large-scale administration of indomethacin]. ( Jimbow, K; Kawamura, M; Maeda, K; Miura, S, 1984)
"Indomethacin was found to inhibit TPA-induced ornithine decarboxylase activity to the same extent in both mice."1.27Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: a comparison between SENCAR and NMRI mice. ( Fischer, SM; Fürstenberger, G; Marks, F; Slaga, TJ, 1987)
"Indomethacin is a nonsteroidal antiinflammatory agent which may act by inhibiting prostaglandin biosynthesis."1.26Inhibition of ultraviolet-B epidermal ornithine decarboxylase induction and skin carcinogenesis in hairless mice by topical indomethacin and triamcinolone acetonide. ( Breeding, J; Chalet, M; Connor, MJ; Lowe, NJ, 1982)
"Flurbiprofen was also observed to enhance promotion slightly."1.26Indomethacin enhancement of TPA tumor promotion in mice. ( Fischer, SM; Gleason, GL; Mills, GD; Slaga, TJ, 1980)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199022 (48.89)18.7374
1990's16 (35.56)18.2507
2000's3 (6.67)29.6817
2010's4 (8.89)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Motohashi, S1
Akihisa, T1
Tamura, T1
Tokutake, N1
Takido, M1
Yasukawa, K2
Tse, AK1
Cao, HH1
Cheng, CY1
Kwan, HY1
Yu, H1
Fong, WF1
Yu, ZL1
Prasad, R1
Katiyar, SK1
Somasundaram, R1
Herlyn, M1
Patel, T1
Kirsner, RS1
Iida, T1
Fujimoto, Y1
Park, WH1
Joo, ST1
Park, KK1
Chang, YC1
Kim, CH1
Chiu, LC1
Tong, KF1
Ooi, VE1
Tobia, L1
Al-Salem, T1
Ali, ZS1
Qassab, M1
Minassian, AA1
Kadagidze, ZG1
Verma, AK6
Ashendel, CL3
Boutwell, RK6
Fürstenberger, G4
Richter, H2
Argyris, TS1
Marks, F4
Maeda, K1
Miura, S1
Kawamura, M1
Jimbow, K1
Takenaga, K1
Hozumi, M1
Astrup, E1
Berry, DL1
Bertsch, S1
Lowe, NJ1
Connor, MJ1
Breeding, J1
Chalet, M1
Fischer, SM5
Gleason, GL2
Bohrman, JS1
Slaga, TJ4
Mills, GD1
Reeve, VE1
Matheson, MJ1
Bosnic, M1
Boehm-Wilcox, C1
Haedersdal, M1
Poulsen, T1
Wulf, HC1
Kudriavtsev, IA1
Miasishcheva, NV1
Jiang, H1
Yamamoto, S1
Kato, R1
Kochevar, IE1
Moran, M1
Lyon, N1
Flotte, T1
Siebert, E1
Gange, RW1
Kiriyama, T1
Gillespie, MT1
Glatz, JA1
Fukumoto, S1
Moseley, JM1
Martin, TJ1
Janik, JE1
Miller, LL1
Longo, DL1
Powers, GC1
Urba, WJ1
Kopp, WC1
Gause, BL1
Curti, BD1
Fenton, RG1
Oppenheim, JJ1
Conlon, KC1
Holmlund, JT1
Sznol, M1
Sharfman, WH1
Steis, RG1
Creekmore, SP1
Alvord, WG1
Beauchamp, AE1
Smith, JW1
Mertens, WC1
Lohmann, RC1
Lo, HH1
Gordon, GB1
Seibert, K1
Kelloff, G1
Lubet, RA1
Conti, CJ1
O'Brien, TG1
Weekes, RG1
DeYoung, LM1
Astrup, EG1
Goerttler, K1
Edler, L1
Loehrke, H1
Mentz, P1
Giessler, C1
Andrews, J1
Halliday, GM1
Muller, HK1
Patrick, KE1
Patamalai, B1
Faradzhev, ZG3
Mazina, NM1
Ivshina, AV1
Ishihara, K1
al-Waili, NS1
Samsonov, VA1
Bassalyk, LS1
Nemtsova, MP1
Gross, M1
Loprinzi, CL2
Carbone, PP1

Reviews

1 review available for indomethacin and Cancer of Skin

ArticleYear
Mouse skin: a useful model system for studying the mechanism of chemical carcinogenesis.
    Carcinogenesis; a comprehensive survey, 1982, Volume: 7

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Carcinogens; Cell Communication; Cell

1982

Trials

2 trials available for indomethacin and Cancer of Skin

ArticleYear
Phase II trial of interleukin 1 alpha and indomethacin in treatment of metastatic melanoma.
    Journal of the National Cancer Institute, 1996, Jan-03, Volume: 88, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chi-Square Distribution; Female; HLA-B

1996
Oral indomethacin and ranitidine in advanced melanoma: a phase II study.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1996, Volume: 8, Issue:2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antin

1996

Other Studies

42 other studies available for indomethacin and Cancer of Skin

ArticleYear
Alkane-6,8-diol: inhibitor of tumor promotion in two-stage carcinogenesis in mouse skin.
    Journal of medicinal chemistry, 1995, Oct-13, Volume: 38, Issue:21

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Fa

1995
Indomethacin sensitizes TRAIL-resistant melanoma cells to TRAIL-induced apoptosis through ROS-mediated upregulation of death receptor 5 and downregulation of survivin.
    The Journal of investigative dermatology, 2014, Volume: 134, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line, Tumor; Down-Regulation; Drug Resistan

2014
Ultraviolet radiation-induced inflammation activates β-catenin signaling in mouse skin and skin tumors.
    International journal of oncology, 2014, Volume: 44, Issue:4

    Topics: Animals; beta Catenin; Casein Kinase I; Cyclin D1; Cyclin D2; Cyclooxygenase 2; Cyclooxygenase 2 Inh

2014
Indomethacin to the rescue of TRAIL-resistant melanomas.
    The Journal of investigative dermatology, 2014, Volume: 134, Issue:5

    Topics: Humans; Indomethacin; Inhibitor of Apoptosis Proteins; Melanoma; Receptors, TNF-Related Apoptosis-In

2014
JID VisualDx quiz: May 2014.
    The Journal of investigative dermatology, 2014, Volume: 134, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Melanoma; Skin Neoplasms

2014
Relative inhibitory activity of bile acids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, and chenodeoxycholic acid inhibition of tumour promotion in mouse skin two-stage carcinogenesis.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Bile A

2009
Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.
    Immunopharmacology and immunotoxicology, 2004, Volume: 26, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Hepat

2004
Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2005, Volume: 59 Suppl 2

    Topics: Antineoplastic Agents; Aspirin; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Cyclooxygen

2005
[The therapeutic problem of cutaneous photosensitization. Considerations on a case of xeroderma pigmentosum].
    Archivio per le scienze mediche, 1967, Volume: 123, Issue:3

    Topics: Adolescent; Carcinoma, Basal Cell; Female; Humans; Indomethacin; Photosensitivity Disorders; Skin Ne

1967
Skin cancers in xeroderma pigmentosum: response to indomethacin and steroids.
    Lancet (London, England), 1980, Aug-02, Volume: 2, Issue:8188

    Topics: Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Indomethacin;

1980
Suppressor cells in melanoma and lung cancer: correlation with the clinical stage.
    Neoplasma, 1983, Volume: 30, Issue:2

    Topics: Adult; Aged; Humans; Indomethacin; Lung Neoplasms; Melanoma; Middle Aged; Neoplasm Staging; Phytohem

1983
Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
    Cancer research, 1980, Volume: 40, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Carboxy-Lyases; Cyclooxygenase Inhibitors; Female; Ind

1980
Effects of the phorbol ester 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo: evidence for its uselessness as a negative control compound in studies on the biological effects of phorbol ester tumor promoters.
    Cancer research, 1982, Volume: 42, Issue:1

    Topics: Animals; Cell Division; Cocarcinogenesis; Cyclic AMP; Epidermis; Female; Growth Inhibitors; Indometh

1982
On the role of tumour promotion in chemical carcinogenesis.
    IARC scientific publications, 1984, Issue:56

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dexamethasone; DNA Replication; Hyperplasia;

1984
[Control of multiple skin and lung metastasis of malignant melanoma by combined DAV and OK-432 chemoimmunotherapy in association with large-scale administration of indomethacin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Humans; Indomethacin; Lung Neopla

1984
[Cellular actions of inhibitors of chemical carcinogenesis: modifications of syntheses of prostaglandins and differentiation of myeloid leukemia cells].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:9

    Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Dexamethasone; Humans; Indomethacin; Leukem

1983
On the relationship between epidermal hyperproliferation and skin tumor promotion.
    Carcinogenesis; a comprehensive survey, 1982, Volume: 7

    Topics: Calcimycin; Cell Division; Cocarcinogenesis; Dinoprost; Dinoprostone; Epidermal Cells; Hyperplasia;

1982
Inhibition of ultraviolet-B epidermal ornithine decarboxylase induction and skin carcinogenesis in hairless mice by topical indomethacin and triamcinolone acetonide.
    Cancer research, 1982, Volume: 42, Issue:10

    Topics: Animals; Carboxy-Lyases; Carcinogens; Enzyme Induction; Female; Indomethacin; Mice; Mice, Mutant Str

1982
Prostaglandin enhancement of skin tumor initiation and promotion.
    Advances in prostaglandin and thromboxane research, 1980, Volume: 6

    Topics: Animals; Indomethacin; Mice; Neoplasms, Experimental; Phorbols; Prostaglandins; Prostaglandins E; Pr

1980
An organ culture of adult mouse skin: an in vitro model for studying the molecular mechanism of skin tumor promotion.
    Biochemical and biophysical research communications, 1980, Sep-30, Volume: 96, Issue:2

    Topics: Animals; Carboxy-Lyases; DNA; Enzyme Induction; Female; Indomethacin; Mice; Models, Biological; Neop

1980
Indomethacin enhancement of TPA tumor promotion in mice.
    Cancer letters, 1980, Volume: 10, Issue:4

    Topics: Animals; Drug Synergism; Female; Flurbiprofen; Indomethacin; Mice; Neoplasms, Experimental; Papillom

1980
The protective effect of indomethacin on photocarcinogenesis in hairless mice.
    Cancer letters, 1995, Aug-16, Volume: 95, Issue:1-2

    Topics: Animals; Carcinoma, Squamous Cell; Diet; Erythema; Female; Indomethacin; Mice; Mice, Hairless; Neopl

1995
Effects of systemic indomethacin on photocarcinogenesis in hairless mice.
    Journal of cancer research and clinical oncology, 1995, Volume: 121, Issue:5

    Topics: Animals; DNA Damage; Female; Indomethacin; Mice; Mice, Hairless; Mice, Inbred C3H; Skin Neoplasms; U

1995
[Synthesis of arachidonic acid cascade eicosanoids in tumors of various histogenesis in mice].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1995, Issue:4

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenocarcinoma; Animals; Arachidonic Acid; Carcinoma, Le

1995
Inhibition of two-stage skin carcinogenesis as well as complete skin carcinogenesis by oral administration of TMK688, a potent lipoxygenase inhibitor.
    Carcinogenesis, 1994, Volume: 15, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Anticarcin

1994
Effects of systemic indomethacin, meclizine, and BW755C on chronic ultraviolet B-induced effects in hairless mouse skin.
    The Journal of investigative dermatology, 1993, Volume: 100, Issue:2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Fem

1993
Transforming growth factor beta stimulation of parathyroid hormone-related protein (PTHrP): a paracrine regulator?
    Molecular and cellular endocrinology, 1993, Volume: 92, Issue:1

    Topics: Base Sequence; Carcinoma, Squamous Cell; Culture Media, Conditioned; Gene Expression Regulation, Neo

1993
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis.
    Molecular carcinogenesis, 1999, Volume: 25, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Celecoxib; Cell Division; Cyclooxygen

1999
The induction of ornithine decarboxylase activity and its control in mouse skin epidermis.
    Advances in enzyme regulation, 1978, Volume: 17

    Topics: Adenosylmethionine Decarboxylase; Alkaloids; Amines; Animals; Carboxy-Lyases; Enzyme Induction; Epid

1978
Long term tumorigenicity of a single application of indomethacin or Amuno in adolescent and in adult male Sprague Dawley rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1992, Volume: 44, Issue:7

    Topics: Aging; Animals; Body Weight; Epidermis; Hyperplasia; Indomethacin; Leydig Cell Tumor; Liver Neoplasm

1992
Biosynthesis of TXB2 and 6-oxo-PGF1 alpha in the heart and other tissues under pathophysiological conditions.
    Agents and actions. Supplements, 1992, Volume: 37

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aqueous Humor; Brain Diseases; Child; Gastric Mucosa; Gastrit

1992
A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice.
    Clinical and experimental immunology, 1991, Volume: 85, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Presenti

1991
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
    Carcinogenesis, 1990, Volume: 11, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capillary Permeability; Cimetidine; Diphenhydramine; Fema

1990
[The functioning of the interferon system in mycosis fungoides patients undergoing different methods of therapy].
    Vestnik dermatologii i venerologii, 1990, Issue:6

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chronic Disease; Drug Evalu

1990
[The effect of therapy on the immunological indices in patients with skin lymphomas and Kaposi's sarcoma].
    Vestnik dermatologii i venerologii, 1990, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chronic Disease; Humans; In

1990
[Therapeutic response of interferon-beta in malignant melanoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:4 Pt 1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Female; Humans;

1986
Indomethacin in basal cell carcinoma.
    JPMA. The Journal of the Pakistan Medical Association, 1989, Volume: 39, Issue:5

    Topics: Carcinoma, Basal Cell; Female; Humans; Indomethacin; Middle Aged; Prostaglandins; Skin Neoplasms

1989
[The effectiveness of treating patients with malignant skin lymphoma and Kaposi's sarcoma studied via polyamines].
    Vestnik dermatologii i venerologii, 1989, Issue:11

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chronic Disease; Drug Evalu

1989
Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion).
    Carcinogenesis, 1989, Volume: 10, Issue:1

    Topics: Animals; Cocarcinogenesis; Dinoprost; Dinoprostone; Epidermis; Indomethacin; Mice; Papilloma; Phorbo

1989
Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: a comparison between SENCAR and NMRI mice.
    Cancer research, 1987, Jun-15, Volume: 47, Issue:12

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; DNA Rep

1987
Inhibition of phorbol ester--induced human epidermal ornithine decarboxylase activity by oral compounds: a possible role in human chemoprevention studies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:6

    Topics: Adult; Cells, Cultured; Enzyme Induction; Female; Humans; Indomethacin; Isotretinoin; Male; Ornithin

1985
Dose and schedule of oral retinoic acid and indomethacin needed to effectively inhibit phorbol ester-induced epidermal ornithine decarboxylase activity.
    Carcinogenesis, 1985, Volume: 6, Issue:11

    Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Femal

1985