indomethacin has been researched along with Cancer of Intestines in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aspirin (400 ppm) has a similar impact on reducing prostaglandin levels, but in contrast to indomethacin, is uneffective in reducing the tumor load." | 1.31 | Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice. ( Chiu, CH; McEntee, MF; Whelan, J, 2000) |
| "Cimetidine is a histamine type 2 receptor antagonist and indomethacin is an inhibitor of prostaglandin synthesis." | 1.27 | Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat. ( Caignard, A; Martin, F; Martin, M; Reisser, D; Thomas, B, 1984) |
| "Indomethacin treatment completely prevented the carcinogenic effect of methylazoxymethanol." | 1.27 | Antitumor effects of inhibitors of arachidonic acid cascade on experimentally induced intestinal tumors. ( Birkenfeld, S; Kohen, F; Krispin, M; Zakut, H; Zaltsman, YA; Zor, U, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kitamura, T | 1 |
| Itoh, M | 1 |
| Noda, T | 1 |
| Matsuura, M | 1 |
| Wakabayashi, K | 1 |
| Rampton, DS | 1 |
| Hawkey, CJ | 1 |
| Caignard, A | 1 |
| Martin, M | 1 |
| Reisser, D | 1 |
| Thomas, B | 1 |
| Martin, F | 1 |
| Narisawa, T | 3 |
| Hermanek, P | 1 |
| Habs, M | 1 |
| Schmähl, D | 1 |
| Pollard, M | 5 |
| Luckert, PH | 5 |
| Schmidt, MA | 1 |
| Kudo, T | 1 |
| Abo, S | 1 |
| Whelan, J | 2 |
| Chiu, CH | 2 |
| McEntee, MF | 2 |
| MacGregor, DJ | 1 |
| Kim, YS | 1 |
| Sleisenger, MH | 1 |
| Johnson, LK | 1 |
| Collington, GK | 1 |
| Allen, CN | 1 |
| Simmons, NL | 1 |
| Hirst, BH | 1 |
| Takahashi, M | 1 |
| Niwa, M | 1 |
| Koyama, H | 1 |
| Kusaka, H | 1 |
| Yamazaki, Y | 1 |
| Nagasawa, O | 1 |
| Kotanagi, H | 1 |
| Koyama, K | 1 |
| Birkenfeld, S | 1 |
| Zaltsman, YA | 1 |
| Krispin, M | 1 |
| Zakut, H | 1 |
| Zor, U | 1 |
| Kohen, F | 1 |
| Fiocchi, C | 1 |
| Tubbs, RR | 1 |
| Youngman, KR | 1 |
| Dittmar, FK | 1 |
| el-Salamouny, AR | 1 |
1 review available for indomethacin and Cancer of Intestines
| Article | Year |
|---|---|
Prostaglandins and ulcerative colitis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Colitis, Ulcerative; Cyclooxygenase Inhibitors; Dogs; | 1984 |
17 other studies available for indomethacin and Cancer of Intestines
| Article | Year |
|---|---|
Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclooxygenase 1; Cyclooxygenase 2; Cycloox | 2004 |
Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Colonic | 1984 |
Reduction of acetoxymethyl-methylnitrosamine-induced large bowel cancer in rats by indomethacin.
Topics: Animals; Dimethylnitrosamine; Indomethacin; Intestinal Neoplasms; Intestine, Large; Male; Rats; Rats | 1984 |
Prolonged antitumor effect of indomethacin on autochthonous intestinal tumors in rats.
Topics: Animals; Azo Compounds; Dimethylhydrazines; Indomethacin; Intestinal Neoplasms; Male; Methylazoxymet | 1983 |
The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat.
Topics: Animals; Body Weight; Diet; Indomethacin; Intestinal Neoplasms; Male; Methylazoxymethanol Acetate; P | 1983 |
Antitumor activity of indomethacin on methylazoxymethanol-induced large bowel tumors in rats.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Indomethacin; Intestinal Neoplasms; Intestine, Large | 1980 |
Treatment of chemically-induced intestinal cancers with indomethacin.
Topics: Animals; Dimethylhydrazines; Female; Indomethacin; Intestinal Neoplasms; Male; Methylazoxymethanol A | 1981 |
Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine.
Topics: Animals; Dimethylnitrosamine; Indomethacin; Intestinal Neoplasms; Male; Neoplasms, Experimental; Rat | 1981 |
Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors.
Topics: Animals; Body Weight; Diet; Dimethylhydrazines; Indomethacin; Intestinal Neoplasms; Liver; Male; Met | 1980 |
Intestinal tumor load in the Min/+ mouse model is not correlated with eicosanoid biosynthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Dinoprostone; Eicosanoi | 1999 |
Chemoprevention of colon cancer carcinogenesis by balsalazide: inhibition of azoxymethane-induced aberrant crypt formation in the rat colon and intestinal tumor formation in the B6-Min/+ mouse.
Topics: Aminosalicylic Acids; Animals; Anti-Ulcer Agents; Anticarcinogenic Agents; Azoxymethane; Cell Divisi | 2000 |
Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice.
Topics: 6-Ketoprostaglandin F1 alpha; Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Ste | 2000 |
Pharmacological profile of inhibition of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein efflux in human HCT-8 intestinal epithelial cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 1991 |
[Increased mucosal ornithine decarboxylase activity in carcinoma-bearing large bowel and its inhibition by indomethacin].
Topics: Adenocarcinoma; Adenoma; Adult; Aged; Aged, 80 and over; Depression, Chemical; Female; Humans; Indom | 1988 |
Antitumor effects of inhibitors of arachidonic acid cascade on experimentally induced intestinal tumors.
Topics: Animals; Arachidonic Acids; Catechols; Indomethacin; Intestinal Neoplasms; Male; Masoprocol; Methyla | 1987 |
Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Cell Fractionation; Cell Line; Cell Nucleus; Coliti | 1985 |
[Experiences with an indoleacetic acid derivate (Indomethacin) in the therapy of posttraumatic and postoperative edema].
Topics: Abscess; Cellulitis; Edema; Fractures, Bone; Humans; Indomethacin; Inflammation; Intestinal Neoplasm | 1968 |