Page last updated: 2024-10-29

indomethacin and Cachexia

indomethacin has been researched along with Cachexia in 30 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.

Research Excerpts

ExcerptRelevanceReference
" We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice."7.72Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004)
"Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice."5.28Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991)
"Unselected cancer patients (n = 108) who experienced progressive cachexia were randomized to receive either anti-inflammatory treatment alone (indomethacin) or recombinant erythropoietin plus indomethacin to prevent the appearance of disease-induced anemia and thereby protect patients' exercise capacity."5.11Effects of recombinant erythropoietin in palliative treatment of unselected cancer patients. ( Daneryd, P; Fouladiun, M; Hyltander, A; Körner, U; Lindholm, E; Lundholm, K, 2004)
" One hundred eight cancer patients who experienced progressive cachexia due to solid, mainly gastrointestinal tumors were randomized to receive twice daily a cyclo-oxygenase inhibitor (controls; indomethacin, 50 mg twice a day) or indomethacin and erythropoietin, provided on individual basis to prevent development of progressive anemia (study patients; indomethacin, 50 mg twice a day plus rhEPO; range, 12,000-30,000 units per week)."5.08Protection of metabolic and exercise capacity in unselected weight-losing cancer patients following treatment with recombinant erythropoietin: a randomized prospective study. ( Bosaeus, I; Brevinge, H; Daneryd, P; Körner, U; Lindholm, E; Lundholm, K; Pettersson, C; Sandström, R; Svanberg, E, 1998)
" We report that indomethacin, a nonspecific inhibitor of COX, and NS398, a specific inhibitor of COX2, preserved muscle mass and reduced type 1 TNF receptors in muscles of mice bearing the Lewis lung carcinoma, but not in mice bearing the B16 melanoma."3.73Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma. ( Graves, E; McCarthy, DO; Ramsay, E, 2006)
"To assess the putative involvement of NF-kappaB and pro-inflammatory cytokines in the pathogenesis of cancer cachexia and the therapeutic efficacy of indomethacin (IND) on cachexia."3.72Role of NF-kappaB and cytokine in experimental cancer cachexia. ( Jiang, J; Jiang, ZW; Li, JS; Li, N; Tian, J; Zhou, W, 2003)
" We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice."3.72Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004)
"To assess the putative involvement of NF-kappaB and pro-inflammatory cytokines in the pathogenesis of cancer cachexia and the therapeutic efficacy of indomethacin (IND) on cachexia."3.72[Role of NF-kappa B in cancer cachexia]. ( Jiang, J; Jiang, ZW; Li, JS; Li, N; Zhou, W, 2004)
"To investigate the relationship between cytokine IL-6, IL-1, TNF-alpha and experimental cancer cachexia as well as observe the effect of indomethacin on the cachectic mice."3.71[Cytokines in experimental cancer cachexia]. ( Li, T; Liu, A; Niu, Q, 2001)
" Therefore, the purpose of the present study was to determine if administration of ibuprofen (ibu) or indomethacin (indo), which inhibit PG synthesis, would affect the food intake and body weight of tumor-bearing rats."3.70Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats. ( McCarthy, DO, 1999)
"Cancer cachexia is a devastating syndrome of advanced malignancy which negatively impacts on patients' morbidity, mortality and quality of life."2.49Non-steroidal anti-inflammatory drugs for the treatment of cancer cachexia: a systematic review. ( Cantwell, MM; Hughes, CM; Murray, LJ; Parsons, C; Reid, J, 2013)
"Pain and cachexia are two of the most debilitating aspects of rheumatoid arthritis."1.33Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis. ( Ho, WH; Pons, J; Rosenthal, A; Shelton, DL; Zeller, J, 2005)
"Weight-losing untreated cancer patients had elevated resting energy expenditure compared to undernourished non-cancer patients (23."1.32Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. ( Bosaeus, I; Daneryd, P; Hyltander, A; Körner, U; Lundholm, K, 2004)
"Indomethacin was provided in the drinking water to explore interactions between host and tumor-derived prostaglandins and proinflammatory cytokines for tumor growth."1.31Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia. ( Axelsson, H; Cahlin, C; Körner, A; Lundholm, K; Svanberg, E; Wang, W, 2000)
"Local inflammation was induced by subcutaneous injection of turpentine (100 microl/mouse)."1.30Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic inflammation. ( Conn, CA; Kluger, MJ; Kozak, W; Rudolph, K; Soszynski, D, 1997)
"Indomethacin treatment did not affect either of the two CPT activities of the mitochondria isolated from tumour tissue."1.30Carnitine palmitoyltransferase II activity is decreased in liver mitochondria of cachectic rats bearing the Walker 256 carcinosarcoma: effect of indomethacin treatment. ( Colquhoun, A; Curi, R; Seelaender, MC; Williams, JF; Zammitt, VA, 1998)
"A new model of cachexia is described in which muscle protein metabolism related to the ubiquitin-proteasome pathway was investigated."1.30A new model of cancer cachexia: contribution of the ubiquitin-proteasome pathway. ( Brand, SJ; Coggins, MB; Destree, AT; Dick, LR; Elliott, PJ; Goldberg, AL; Huang, JQ; Lazarus, DD; Mazzola, LM; McCormack, TA; Pierce, JW; Read, MA; Solomon, V; Xu, B, 1999)
"Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice."1.28Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991)
"The ability of 13 of the cancer samples to induce muscle proteolysis was significantly inhibited by incubation of muscles in presence of indomethacin (10 microM)."1.28Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss. ( Belizario, JE; Chenker, E; Katz, M; Raw, I, 1991)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.33)18.7374
1990's9 (30.00)18.2507
2000's17 (56.67)29.6817
2010's3 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, B1
Li, YX1
Pan, HR1
Chen, SZ1
Qiu, ZG1
Reid, J1
Hughes, CM1
Murray, LJ1
Parsons, C1
Cantwell, MM1
Zhou, W2
Jiang, ZW2
Tian, J1
Jiang, J2
Li, N2
Li, JS2
Lundholm, K7
Daneryd, P4
Körner, U3
Hyltander, A2
Bosaeus, I2
McCarthy, DO4
Whitney, P1
Hitt, A2
Al-Majid, S1
Lindholm, E2
Fouladiun, M1
Graves, E2
Wang, W2
Andersson, M1
Lõnnroth, C2
Svanberg, E3
Shelton, DL1
Zeller, J1
Ho, WH1
Pons, J1
Rosenthal, A1
Ramsay, E1
Diament, MJ1
Peluffo, GD1
Stillitani, I1
Cerchietti, LC1
Navigante, A1
Ranuncolo, SM1
Klein, SM1
Granado, M1
Martín, AI1
Villanúa, MA1
López-Calderón, A1
de Sá-Nakanishi, AB1
Bracht, F1
Yamamoto, NS1
Padilha, F1
Kelmer-Bracht, AM1
Bracht, A1
Smith, KL1
Tisdale, MJ1
Roe, SY1
Cooper, AL1
Morris, ID1
Rothwell, NJ1
Kozak, W1
Soszynski, D1
Rudolph, K1
Conn, CA1
Kluger, MJ1
Seelaender, MC1
Curi, R2
Colquhoun, A1
Williams, JF1
Zammitt, VA1
Sandström, R1
Brevinge, H1
Pettersson, C1
Lazarus, DD1
Destree, AT1
Mazzola, LM1
McCormack, TA1
Dick, LR1
Xu, B1
Huang, JQ1
Pierce, JW1
Read, MA1
Coggins, MB1
Solomon, V1
Goldberg, AL1
Brand, SJ1
Elliott, PJ1
Cahlin, C2
Gelin, J2
Delbro, D1
Doi, C1
Körner, A1
Axelsson, H1
Eli, Y1
Przedecki, F1
Levin, G1
Kariv, N1
Raz, A1
Niu, Q1
Li, T1
Liu, A1
Andersson, C1
Belizario, JE1
Katz, M1
Chenker, E1
Raw, I1
Homem-de-Bittencourt Júnior, PI1
Pontieri, V1
Lopes, OU1

Reviews

1 review available for indomethacin and Cachexia

ArticleYear
Non-steroidal anti-inflammatory drugs for the treatment of cancer cachexia: a systematic review.
    Palliative medicine, 2013, Volume: 27, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Celecoxib; Cyclooxygenase 2 I

2013

Trials

3 trials available for indomethacin and Cachexia

ArticleYear
Effects of recombinant erythropoietin in palliative treatment of unselected cancer patients.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Oct-15, Volume: 10, Issue:20

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Cachexia; Drug Therapy, Combination;

2004
Protection of metabolic and exercise capacity in unselected weight-losing cancer patients following treatment with recombinant erythropoietin: a randomized prospective study.
    Cancer research, 1998, Dec-01, Volume: 58, Issue:23

    Topics: Aged; Anemia; Anti-Inflammatory Agents, Non-Steroidal; Cachexia; Cyclooxygenase Inhibitors; Energy M

1998
Epoetin alfa for protection of metabolic and exercise capacity in cancer patients.
    Seminars in oncology, 2002, Volume: 29, Issue:3 Suppl 8

    Topics: Aged; Anemia; Anti-Inflammatory Agents, Non-Steroidal; Cachexia; Cyclooxygenase Inhibitors; Energy M

2002

Other Studies

26 other studies available for indomethacin and Cachexia

ArticleYear
[Study on Regulation Effects of Yiqiyangyin Formula on Advanced Lung Cancer Cachexia Mice].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2016, Volume: 39, Issue:6

    Topics: Animals; Cachexia; Cytokines; Indomethacin; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL

2016
Combined treatment with GH, insulin, and indomethacin alleviates cancer cachexia in a mouse model.
    The Journal of endocrinology, 2011, Volume: 208, Issue:2

    Topics: Adenocarcinoma; Animals; Biomarkers; Body Weight; Cachexia; Colonic Neoplasms; Cytokines; Drug Combi

2011
Role of NF-kappaB and cytokine in experimental cancer cachexia.
    World journal of gastroenterology, 2003, Volume: 9, Issue:7

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Composition; Cachexia; Coloni

2003
Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia.
    International journal of oncology, 2004, Volume: 24, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Blood Sedim

2004
Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma.
    Research in nursing & health, 2004, Volume: 27, Issue:3

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Colonic Neo

2004
[Role of NF-kappa B in cancer cachexia].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 2004, Jun-07, Volume: 42, Issue:11

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cachexia; Colonic Neoplasms; Indom

2004
Indomethacin preserves muscle mass and reduces levels of E3 ligases and TNF receptor type 1 in the gastrocnemius muscle of tumor-bearing mice.
    Research in nursing & health, 2005, Volume: 28, Issue:1

    Topics: Adenocarcinoma; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, We

2005
Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexia.
    International journal of cancer, 2005, Jul-01, Volume: 115, Issue:4

    Topics: Animals; Base Sequence; Body Weight; Cachexia; Dinoprostone; Disease Models, Animal; DNA Primers; DN

2005
Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis.
    Pain, 2005, Volume: 116, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Experimental; C

2005
Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma.
    Research in nursing & health, 2006, Volume: 29, Issue:2

    Topics: Analysis of Variance; Animals; Cachexia; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Female; I

2006
Inhibition of tumor progression and paraneoplastic syndrome development in a murine lung adenocarcinoma by medroxyprogesterone acetate and indomethacin.
    Cancer investigation, 2006, Volume: 24, Issue:2

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Hormonal; A

2006
Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 292, Issue:6

    Topics: Animals; Arthritis, Experimental; Cachexia; Chronic Disease; Cyclooxygenase 2; Cyclooxygenase 2 Inhi

2007
The action of extracellular NAD+ in the liver of healthy and tumor-bearing rats: model analysis of the tumor-induced modified response.
    Experimental and molecular pathology, 2008, Volume: 84, Issue:3

    Topics: Animals; Cachexia; Carcinoma 256, Walker; Eicosanoids; Extracellular Fluid; Glucose; Hemodynamics; I

2008
Mechanism of muscle protein degradation in cancer cachexia.
    British journal of cancer, 1993, Volume: 68, Issue:2

    Topics: Adenocarcinoma; Animals; Cachexia; Dinoprostone; Eicosapentaenoic Acid; Female; Indomethacin; Mice;

1993
Involvement of prostaglandins in cachexia induced by T-cell leukemia in the rat.
    Metabolism: clinical and experimental, 1997, Volume: 46, Issue:4

    Topics: Animals; Body Temperature Regulation; Body Weight; Cachexia; Feeding Behavior; Flurbiprofen; Indomet

1997
Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic inflammation.
    The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 2

    Topics: Animals; Anorexia; Behavior, Animal; Body Temperature; Body Weight; Cachexia; Coconut Oil; Fatty Aci

1997
Carnitine palmitoyltransferase II activity is decreased in liver mitochondria of cachectic rats bearing the Walker 256 carcinosarcoma: effect of indomethacin treatment.
    Biochemistry and molecular biology international, 1998, Volume: 44, Issue:1

    Topics: Animals; Cachexia; Carcinoma 256, Walker; Carnitine O-Palmitoyltransferase; Cell Division; Dinoprost

1998
A new model of cancer cachexia: contribution of the ubiquitin-proteasome pathway.
    The American journal of physiology, 1999, Volume: 277, Issue:2

    Topics: Animals; Cachexia; Cysteine Endopeptidases; Dexamethasone; Disease Models, Animal; Glucocorticoids;

1999
Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats.
    Research in nursing & health, 1999, Volume: 22, Issue:5

    Topics: Analysis of Variance; Animals; Anorexia; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cache

1999
Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids.
    Cancer research, 2000, Mar-15, Volume: 60, Issue:6

    Topics: Animals; Cachexia; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression

2000
Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia.
    Cancer research, 2000, Oct-01, Volume: 60, Issue:19

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Body Weight; Cachexia; Cell Division;

2000
Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo.
    Biochemical pharmacology, 2001, Mar-01, Volume: 61, Issue:5

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apopt

2001
[Cytokines in experimental cancer cachexia].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2001, Volume: 23, Issue:5

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Cachex

2001
Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia.
    Cancer research, 1991, Feb-01, Volume: 51, Issue:3

    Topics: Animals; Body Weight; Cachexia; Cyclosporins; Eating; Female; Indomethacin; Interleukin-1; Interleuk

1991
Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss.
    British journal of cancer, 1991, Volume: 63, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Blood Proteins; Cachexia; Child; Diaphragm; Fem

1991
Effects of aspirin-like drugs on Walker 256 tumor growth and cachexia in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1989, Volume: 22, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Weight; Cachexia; Carcinoma 256, Wal

1989